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Patent code US9611251

Compile Data Set for Download or QSAR

Found 546 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Orexin receptor type 1


(Homo sapiens (Human))
BDBM314571
PNG
((3-fluoro-2-(pyrimidin-2-yl)phenyl)((2S*,3R*)-2-me...)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1cccc(F)c1-c1ncccn1)Nc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C23H21F4N5O/c1-14-18(31-19-9-8-15(13-30-19)23(25,26)27)7-3-12-32(14)22(33)16-5-2-6-17(24)20(16)21-28-10-4-11-29-21/h2,4-6,8-11,13-14,18H,3,7,12H2,1H3,(H,30,31)/t14-,18+/m0/s1
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5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM314566
PNG
((5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S*,3...)
Show SMILES COc1ccc(c(c1)C(=O)N1CCC[C@@H](Nc2cnc(cn2)C(F)(F)F)[C@@H]1C)-n1nccn1
Show InChI InChI=1S/C21H22F3N7O2/c1-13-16(29-19-12-25-18(11-26-19)21(22,23)24)4-3-9-30(13)20(32)15-10-14(33-2)5-6-17(15)31-27-7-8-28-31/h5-8,10-13,16H,3-4,9H2,1-2H3,(H,26,29)/t13-,16+/m0/s1
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6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM175171
PNG
(BDBM314481 | US9115117, 73)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-n1nccn1)Nc1nc2ccccc2o1
Show InChI InChI=1S/C22H23N7O2/c1-14-12-18(29-24-9-10-25-29)20(23-13-14)21(30)28-11-5-7-16(15(28)2)26-22-27-17-6-3-4-8-19(17)31-22/h3-4,6,8-10,12-13,15-16H,5,7,11H2,1-2H3,(H,26,27)/t15-,16+/m0/s1
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7n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM314566
PNG
((5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S*,3...)
Show SMILES COc1ccc(c(c1)C(=O)N1CCC[C@@H](Nc2cnc(cn2)C(F)(F)F)[C@@H]1C)-n1nccn1
Show InChI InChI=1S/C21H22F3N7O2/c1-13-16(29-19-12-25-18(11-26-19)21(22,23)24)4-3-9-30(13)20(32)15-10-14(33-2)5-6-17(15)31-27-7-8-28-31/h5-8,10-13,16H,3-4,9H2,1-2H3,(H,26,29)/t13-,16+/m0/s1
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7n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM175177
PNG
(US9115117, 79 | US9611251, 79)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)cc1-n1nccn1)Nc1cnc(cn1)C(F)(F)F
Show InChI InChI=1S/C21H22F3N7O/c1-13-5-6-15(17(10-13)31-27-7-8-28-31)20(32)30-9-3-4-16(14(30)2)29-19-12-25-18(11-26-19)21(22,23)24/h5-8,10-12,14,16H,3-4,9H2,1-2H3,(H,26,29)/t14-,16+/m0/s1
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7n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM314571
PNG
((3-fluoro-2-(pyrimidin-2-yl)phenyl)((2S*,3R*)-2-me...)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1cccc(F)c1-c1ncccn1)Nc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C23H21F4N5O/c1-14-18(31-19-9-8-15(13-30-19)23(25,26)27)7-3-12-32(14)22(33)16-5-2-6-17(24)20(16)21-28-10-4-11-29-21/h2,4-6,8-11,13-14,18H,3,7,12H2,1H3,(H,30,31)/t14-,18+/m0/s1
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7n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM314517
PNG
(((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyridin-2...)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-n1nccn1)Oc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C21H21F3N6O2/c1-13-5-7-16(30-26-9-10-27-30)19(28-13)20(31)29-11-3-4-17(14(29)2)32-18-8-6-15(12-25-18)21(22,23)24/h5-10,12,14,17H,3-4,11H2,1-2H3/t14-,17+/m0/s1
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7n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM175111
PNG
(US9115117, 13 | US9115117, 14 | US9611251, 14)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)cc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C22H23F3N6O/c1-14-5-7-17(19(12-14)31-27-9-10-28-31)21(32)30-11-3-4-18(15(30)2)29-20-8-6-16(13-26-20)22(23,24)25/h5-10,12-13,15,18H,3-4,11H2,1-2H3,(H,26,29)/t15-,18+/m0/s1
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7n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM175116
PNG
(US9115117, 18 | US9115117, 87 | US9611251, 87)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C21H22F3N7O/c1-13-5-7-17(31-26-9-10-27-31)19(28-13)20(32)30-11-3-4-16(14(30)2)29-18-8-6-15(12-25-18)21(22,23)24/h5-10,12,14,16H,3-4,11H2,1-2H3,(H,25,29)/t14-,16+/m0/s1
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7n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM175177
PNG
(US9115117, 79 | US9611251, 79)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)cc1-n1nccn1)Nc1cnc(cn1)C(F)(F)F
Show InChI InChI=1S/C21H22F3N7O/c1-13-5-6-15(17(10-13)31-27-7-8-28-31)20(32)30-9-3-4-16(14(30)2)29-19-12-25-18(11-26-19)21(22,23)24/h5-8,10-12,14,16H,3-4,9H2,1-2H3,(H,26,29)/t14-,16+/m0/s1
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8n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM175118
PNG
(US9115117, 20 | US9611251, 20)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1cccc(C)c1-n1nccn1)Nc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C22H23F3N6O/c1-14-5-3-6-17(20(14)31-27-10-11-28-31)21(32)30-12-4-7-18(15(30)2)29-19-9-8-16(13-26-19)22(23,24)25/h3,5-6,8-11,13,15,18H,4,7,12H2,1-2H3,(H,26,29)/t15-,18+/m0/s1
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8n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM175130
PNG
(US9115117, 100 | US9115117, 32 | US9611251, 100)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ccc(Cl)cn1
Show InChI InChI=1S/C20H21ClN6O/c1-14-17(25-19-9-8-15(21)13-22-19)6-4-12-26(14)20(28)16-5-2-3-7-18(16)27-23-10-11-24-27/h2-3,5,7-11,13-14,17H,4,6,12H2,1H3,(H,22,25)/t14-,17+/m0/s1
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8n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM175203
PNG
(US9115117, 112 | US9611251, 112)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)cc1-n1nccn1)Oc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C22H22F3N5O2/c1-14-5-7-17(18(12-14)30-27-9-10-28-30)21(31)29-11-3-4-19(15(29)2)32-20-8-6-16(13-26-20)22(23,24)25/h5-10,12-13,15,19H,3-4,11H2,1-2H3/t15-,19+/m0/s1
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8n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM175115
PNG
(US9115117, 17 | US9611251, 17)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1cc(Cl)ccc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C21H20ClF3N6O/c1-13-17(29-19-7-4-14(12-26-19)21(23,24)25)3-2-10-30(13)20(32)16-11-15(22)5-6-18(16)31-27-8-9-28-31/h4-9,11-13,17H,2-3,10H2,1H3,(H,26,29)/t13-,17+/m0/s1
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8n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM175122
PNG
(US9115117, 24 | US9611251, 24)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1cc(F)ccc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C21H20F4N6O/c1-13-17(29-19-7-4-14(12-26-19)21(23,24)25)3-2-10-30(13)20(32)16-11-15(22)5-6-18(16)31-27-8-9-28-31/h4-9,11-13,17H,2-3,10H2,1H3,(H,26,29)/t13-,17+/m0/s1
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8n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM175136
PNG
(US9115117, 38 | US9115117, 85 | US9611251, 85)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1cnc(cn1)C(F)(F)F
Show InChI InChI=1S/C20H20F3N7O/c1-13-15(28-18-12-24-17(11-25-18)20(21,22)23)6-4-10-29(13)19(31)14-5-2-3-7-16(14)30-26-8-9-27-30/h2-3,5,7-9,11-13,15H,4,6,10H2,1H3,(H,25,28)/t13-,15+/m0/s1
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8n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM175139
PNG
(US9115117, 41 | US9611251, 41)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1nc2ccccc2o1
Show InChI InChI=1S/C22H22N6O2/c1-15-17(25-22-26-18-8-3-5-11-20(18)30-22)9-6-14-27(15)21(29)16-7-2-4-10-19(16)28-23-12-13-24-28/h2-5,7-8,10-13,15,17H,6,9,14H2,1H3,(H,25,26)/t15-,17+/m0/s1
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9n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM175111
PNG
(US9115117, 13 | US9115117, 14 | US9611251, 14)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)cc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C22H23F3N6O/c1-14-5-7-17(19(12-14)31-27-9-10-28-31)21(32)30-11-3-4-18(15(30)2)29-20-8-6-16(13-26-20)22(23,24)25/h5-10,12-13,15,18H,3-4,11H2,1-2H3,(H,26,29)/t15-,18+/m0/s1
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9n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM175111
PNG
(US9115117, 13 | US9115117, 14 | US9611251, 14)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)cc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C22H23F3N6O/c1-14-5-7-17(19(12-14)31-27-9-10-28-31)21(32)30-11-3-4-18(15(30)2)29-20-8-6-16(13-26-20)22(23,24)25/h5-10,12-13,15,18H,3-4,11H2,1-2H3,(H,26,29)/t15-,18+/m0/s1
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9n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM314517
PNG
(((2S,3R)-2-methyl-3-((5-(trifluoromethyl)pyridin-2...)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-n1nccn1)Oc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C21H21F3N6O2/c1-13-5-7-16(30-26-9-10-27-30)19(28-13)20(31)29-11-3-4-17(14(29)2)32-18-8-6-15(12-25-18)21(22,23)24/h5-10,12,14,17H,3-4,11H2,1-2H3/t14-,17+/m0/s1
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9n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM314573
PNG
((4-fluoro-2-(pyrimidin-2-yl)phenyl)((2S*,3R*)-2-me...)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccc(F)cc1-c1ncccn1)Nc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C23H21F4N5O/c1-14-19(31-20-8-5-15(13-30-20)23(25,26)27)4-2-11-32(14)22(33)17-7-6-16(24)12-18(17)21-28-9-3-10-29-21/h3,5-10,12-14,19H,2,4,11H2,1H3,(H,30,31)/t14-,19+/m0/s1
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9n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM175139
PNG
(US9115117, 41 | US9611251, 41)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1nc2ccccc2o1
Show InChI InChI=1S/C22H22N6O2/c1-15-17(25-22-26-18-8-3-5-11-20(18)30-22)9-6-14-27(15)21(29)16-7-2-4-10-19(16)28-23-12-13-24-28/h2-5,7-8,10-13,15,17H,6,9,14H2,1H3,(H,25,26)/t15-,17+/m0/s1
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9n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM175136
PNG
(US9115117, 38 | US9115117, 85 | US9611251, 85)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1cnc(cn1)C(F)(F)F
Show InChI InChI=1S/C20H20F3N7O/c1-13-15(28-18-12-24-17(11-25-18)20(21,22)23)6-4-10-29(13)19(31)14-5-2-3-7-16(14)30-26-8-9-27-30/h2-3,5,7-9,11-13,15H,4,6,10H2,1H3,(H,25,28)/t13-,15+/m0/s1
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10n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM175187
PNG
(US9115117, 89 | US9611251, 89)
Show SMILES COc1ccc(c(c1)C(=O)N1CCC[C@@H](Nc2ncc(cn2)C(F)(F)F)[C@@H]1C)-n1nccn1
Show InChI InChI=1S/C21H22F3N7O2/c1-13-17(29-20-25-11-14(12-26-20)21(22,23)24)4-3-9-30(13)19(32)16-10-15(33-2)5-6-18(16)31-27-7-8-28-31/h5-8,10-13,17H,3-4,9H2,1-2H3,(H,25,26,29)/t13-,17+/m0/s1
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10n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM175116
PNG
(US9115117, 18 | US9115117, 87 | US9611251, 87)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C21H22F3N7O/c1-13-5-7-17(31-26-9-10-27-31)19(28-13)20(32)30-11-3-4-16(14(30)2)29-18-8-6-15(12-25-18)21(22,23)24/h5-10,12,14,16H,3-4,11H2,1-2H3,(H,25,29)/t14-,16+/m0/s1
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10n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM175117
PNG
(US9115117, 19 | US9611251, 19)
Show SMILES COc1ccc(c(c1)C(=O)N1CCC[C@@H](Nc2ccc(cn2)C(F)(F)F)[C@@H]1C)-n1nccn1
Show InChI InChI=1S/C22H23F3N6O2/c1-14-18(29-20-8-5-15(13-26-20)22(23,24)25)4-3-11-30(14)21(32)17-12-16(33-2)6-7-19(17)31-27-9-10-28-31/h5-10,12-14,18H,3-4,11H2,1-2H3,(H,26,29)/t14-,18+/m0/s1
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10n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM175117
PNG
(US9115117, 19 | US9611251, 19)
Show SMILES COc1ccc(c(c1)C(=O)N1CCC[C@@H](Nc2ccc(cn2)C(F)(F)F)[C@@H]1C)-n1nccn1
Show InChI InChI=1S/C22H23F3N6O2/c1-14-18(29-20-8-5-15(13-26-20)22(23,24)25)4-3-11-30(14)21(32)17-12-16(33-2)6-7-19(17)31-27-9-10-28-31/h5-10,12-14,18H,3-4,11H2,1-2H3,(H,26,29)/t14-,18+/m0/s1
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10n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM175169
PNG
(US9115117, 71 | US9611251, 71)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)cc1-n1nccn1)Nc1ncc(cn1)C(F)(F)F
Show InChI InChI=1S/C21H22F3N7O/c1-13-5-6-16(18(10-13)31-27-7-8-28-31)19(32)30-9-3-4-17(14(30)2)29-20-25-11-15(12-26-20)21(22,23)24/h5-8,10-12,14,17H,3-4,9H2,1-2H3,(H,25,26,29)/t14-,17+/m0/s1
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10n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM175140
PNG
(US9115117, 42 | US9611251, 42)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ccc(Br)cn1
Show InChI InChI=1S/C20H21BrN6O/c1-14-17(25-19-9-8-15(21)13-22-19)6-4-12-26(14)20(28)16-5-2-3-7-18(16)27-23-10-11-24-27/h2-3,5,7-11,13-14,17H,4,6,12H2,1H3,(H,22,25)/t14-,17+/m0/s1
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10n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM175110
PNG
(US9115117, 12 | US9611251, 12)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C21H21F3N6O/c1-14-17(28-19-9-8-15(13-25-19)21(22,23)24)6-4-12-29(14)20(31)16-5-2-3-7-18(16)30-26-10-11-27-30/h2-3,5,7-11,13-14,17H,4,6,12H2,1H3,(H,25,28)/t14-,17+/m0/s1
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11n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM175115
PNG
(US9115117, 17 | US9611251, 17)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1cc(Cl)ccc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C21H20ClF3N6O/c1-13-17(29-19-7-4-14(12-26-19)21(23,24)25)3-2-10-30(13)20(32)16-11-15(22)5-6-18(16)31-27-8-9-28-31/h4-9,11-13,17H,2-3,10H2,1H3,(H,26,29)/t13-,17+/m0/s1
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11n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM175124
PNG
(US9115117, 26 | US9611251, 26)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C21H22F3N7O/c1-13-10-17(31-27-7-8-28-31)19(26-11-13)20(32)30-9-3-4-16(14(30)2)29-18-6-5-15(12-25-18)21(22,23)24/h5-8,10-12,14,16H,3-4,9H2,1-2H3,(H,25,29)/t14-,16+/m0/s1
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11n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM175146
PNG
(US9115117, 48 | US9611251, 48)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1cnc2ccccc2n1
Show InChI InChI=1S/C23H23N7O/c1-16-18(27-22-15-24-19-8-3-4-9-20(19)28-22)10-6-14-29(16)23(31)17-7-2-5-11-21(17)30-25-12-13-26-30/h2-5,7-9,11-13,15-16,18H,6,10,14H2,1H3,(H,27,28)/t16-,18+/m0/s1
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11n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM314519
PNG
((2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-2-methyl...)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Oc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C21H20F3N5O2/c1-14-18(31-19-9-8-15(13-25-19)21(22,23)24)7-4-12-28(14)20(30)16-5-2-3-6-17(16)29-26-10-11-27-29/h2-3,5-6,8-11,13-14,18H,4,7,12H2,1H3/t14-,18+/m0/s1
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11n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM175120
PNG
(US9115117, 22 | US9115117, 25 | US9611251, 25)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-c1ncco1)Nc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C22H22F3N5O2/c1-13-5-7-16(20-26-9-11-32-20)19(28-13)21(31)30-10-3-4-17(14(30)2)29-18-8-6-15(12-27-18)22(23,24)25/h5-9,11-12,14,17H,3-4,10H2,1-2H3,(H,27,29)/t14-,17+/m0/s1
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11n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM175140
PNG
(US9115117, 42 | US9611251, 42)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ccc(Br)cn1
Show InChI InChI=1S/C20H21BrN6O/c1-14-17(25-19-9-8-15(21)13-22-19)6-4-12-26(14)20(28)16-5-2-3-7-18(16)27-23-10-11-24-27/h2-3,5,7-11,13-14,17H,4,6,12H2,1H3,(H,22,25)/t14-,17+/m0/s1
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11n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM175203
PNG
(US9115117, 112 | US9611251, 112)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)cc1-n1nccn1)Oc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C22H22F3N5O2/c1-14-5-7-17(18(12-14)30-27-9-10-28-30)21(31)29-11-3-4-19(15(29)2)32-20-8-6-16(13-26-20)22(23,24)25/h5-10,12-13,15,19H,3-4,11H2,1-2H3/t15-,19+/m0/s1
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12n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM314573
PNG
((4-fluoro-2-(pyrimidin-2-yl)phenyl)((2S*,3R*)-2-me...)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccc(F)cc1-c1ncccn1)Nc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C23H21F4N5O/c1-14-19(31-20-8-5-15(13-30-20)23(25,26)27)4-2-11-32(14)22(33)17-7-6-16(24)12-18(17)21-28-9-3-10-29-21/h3,5-10,12-14,19H,2,4,11H2,1H3,(H,30,31)/t14-,19+/m0/s1
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12n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM175169
PNG
(US9115117, 71 | US9611251, 71)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)cc1-n1nccn1)Nc1ncc(cn1)C(F)(F)F
Show InChI InChI=1S/C21H22F3N7O/c1-13-5-6-16(18(10-13)31-27-7-8-28-31)19(32)30-9-3-4-17(14(30)2)29-20-25-11-15(12-26-20)21(22,23)24/h5-8,10-12,14,17H,3-4,9H2,1-2H3,(H,25,26,29)/t14-,17+/m0/s1
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12n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM175116
PNG
(US9115117, 18 | US9115117, 87 | US9611251, 87)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C21H22F3N7O/c1-13-5-7-17(31-26-9-10-27-31)19(28-13)20(32)30-11-3-4-16(14(30)2)29-18-8-6-15(12-25-18)21(22,23)24/h5-10,12,14,16H,3-4,11H2,1-2H3,(H,25,29)/t14-,16+/m0/s1
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US Patent
12n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM314597
PNG
(((2S,3R)-3-((5-chloropyridin-2-yl)oxy)-2-methylpip...)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-n1nccn1)Oc1ccc(Cl)cn1
Show InChI InChI=1S/C20H21ClN6O2/c1-13-5-7-16(27-23-9-10-24-27)19(25-13)20(28)26-11-3-4-17(14(26)2)29-18-8-6-15(21)12-22-18/h5-10,12,14,17H,3-4,11H2,1-2H3/t14-,17+/m0/s1
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12n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM175137
PNG
(US9115117, 39 | US9611251, 39)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ncc2ccccc2n1
Show InChI InChI=1S/C23H23N7O/c1-16-19(27-23-24-15-17-7-2-4-9-20(17)28-23)10-6-14-29(16)22(31)18-8-3-5-11-21(18)30-25-12-13-26-30/h2-5,7-9,11-13,15-16,19H,6,10,14H2,1H3,(H,24,27,28)/t16-,19+/m0/s1
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US Patent
12n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM175130
PNG
(US9115117, 100 | US9115117, 32 | US9611251, 100)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ccc(Cl)cn1
Show InChI InChI=1S/C20H21ClN6O/c1-14-17(25-19-9-8-15(21)13-22-19)6-4-12-26(14)20(28)16-5-2-3-7-18(16)27-23-10-11-24-27/h2-3,5,7-11,13-14,17H,4,6,12H2,1H3,(H,22,25)/t14-,17+/m0/s1
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12n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM314519
PNG
((2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-2-methyl...)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Oc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C21H20F3N5O2/c1-14-18(31-19-9-8-15(13-25-19)21(22,23)24)7-4-12-28(14)20(30)16-5-2-3-6-17(16)29-26-10-11-27-29/h2-3,5-6,8-11,13-14,18H,4,7,12H2,1H3/t14-,18+/m0/s1
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12n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM314589
PNG
((3-fluoro-2-(pyrimidin-2-yl)phenyl)((2S*,3R*)-2-me...)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1cccc(F)c1-c1ncccn1)Nc1cnc(cn1)C(F)(F)F
Show InChI InChI=1S/C22H20F4N6O/c1-13-16(31-18-12-29-17(11-30-18)22(24,25)26)7-3-10-32(13)21(33)14-5-2-6-15(23)19(14)20-27-8-4-9-28-20/h2,4-6,8-9,11-13,16H,3,7,10H2,1H3,(H,30,31)/t13-,16+/m0/s1
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12n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM175130
PNG
(US9115117, 100 | US9115117, 32 | US9611251, 100)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccccc1-n1nccn1)Nc1ccc(Cl)cn1
Show InChI InChI=1S/C20H21ClN6O/c1-14-17(25-19-9-8-15(21)13-22-19)6-4-12-26(14)20(28)16-5-2-3-7-18(16)27-23-10-11-24-27/h2-3,5,7-11,13-14,17H,4,6,12H2,1H3,(H,22,25)/t14-,17+/m0/s1
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12n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM175196
PNG
(US9115117, 98 | US9611251, 98)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ccc(C)nc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C21H22F3N7O/c1-13-5-7-16(19(28-13)31-26-9-10-27-31)20(32)30-11-3-4-17(14(30)2)29-18-8-6-15(12-25-18)21(22,23)24/h5-10,12,14,17H,3-4,11H2,1-2H3,(H,25,29)/t14-,17+/m0/s1
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12n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM175116
PNG
(US9115117, 18 | US9115117, 87 | US9611251, 87)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C21H22F3N7O/c1-13-5-7-17(31-26-9-10-27-31)19(28-13)20(32)30-11-3-4-16(14(30)2)29-18-8-6-15(12-25-18)21(22,23)24/h5-10,12,14,16H,3-4,11H2,1-2H3,(H,25,29)/t14-,16+/m0/s1
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13n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM314523
PNG
((3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)...)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1cccc(F)c1-n1nccn1)Oc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C21H19F4N5O2/c1-13-17(32-18-8-7-14(12-26-18)21(23,24)25)6-3-11-29(13)20(31)15-4-2-5-16(22)19(15)30-27-9-10-28-30/h2,4-5,7-10,12-13,17H,3,6,11H2,1H3/t13-,17+/m0/s1
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13n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
Orexin receptor type 1 (OX1)


(Rattus norvegicus (Rat))
BDBM175186
PNG
(US9115117, 88 | US9611251, 88)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-c1ncco1)Nc1nc2ccccc2o1
Show InChI InChI=1S/C23H23N5O3/c1-14-12-16(21-24-9-11-30-21)20(25-13-14)22(29)28-10-5-7-17(15(28)2)26-23-27-18-6-3-4-8-19(18)31-23/h3-4,6,8-9,11-13,15,17H,5,7,10H2,1-2H3,(H,26,27)/t15-,17+/m0/s1
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13n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...


US Patent US9611251 (2017)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%