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Patent code US9611252

Compile Data Set for Download or QSAR
Found 146 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Plasma kallikrein


(Homo sapiens (Human))
BDBM283368
PNG
(N-((5-chloro-1H-indazol-3-yl)methyl)-2-((3- methyl...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3n[nH]c4ccc(Cl)cc34)cc2c1)S(C)(=O)=O
Show InChI InChI=1S/C26H22ClN5O3S/c1-15-7-18-8-16(10-24(36(2,34)35)25(18)29-13-15)9-20-11-17(5-6-28-20)26(33)30-14-23-21-12-19(27)3-4-22(21)31-32-23/h3-8,10-13H,9,14H2,1-2H3,(H,30,33)(H,31,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283381
PNG
(N-((3-chloro-6-fluoro-1H-indol-5-yl)methyl)-2- ((3...)
Show SMILES Fc1cc2[nH]cc(Cl)c2cc1CNC(=O)c1ccnc(Cc2ccc3ncc(Cl)cc3c2)c1
Show InChI InChI=1S/C25H17Cl2FN4O/c26-18-7-16-5-14(1-2-23(16)30-12-18)6-19-8-15(3-4-29-19)25(33)32-11-17-9-20-21(27)13-31-24(20)10-22(17)28/h1-5,7-10,12-13,31H,6,11H2,(H,32,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283398
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cc2cc(C#N)c3ncc(Cl)cc3c2)c1
Show InChI InChI=1S/C25H21ClN6O/c1-14-5-23(28)32-15(2)22(14)13-31-25(33)17-3-4-29-21(10-17)8-16-6-18-9-20(26)12-30-24(18)19(7-16)11-27/h3-7,9-10,12H,8,13H2,1-2H3,(H2,28,32)(H,31,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283399
PNG
(N-((3-chloro-4-fluoro-1H-indol-5-yl)methyl)-2- ((3...)
Show SMILES Fc1c(CNC(=O)c2ccnc(Cc3cc(C#N)c4ncc(Cl)cc4c3)c2)ccc2[nH]cc(Cl)c12
Show InChI InChI=1S/C26H16Cl2FN5O/c27-19-8-17-5-14(6-18(10-30)25(17)33-12-19)7-20-9-15(3-4-31-20)26(35)34-11-16-1-2-22-23(24(16)29)21(28)13-32-22/h1-6,8-9,12-13,32H,7,11H2,(H,34,35)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283404
PNG
(N-((6-amino-2-methylpyridin-3-yl)methyl)-2- ((3-ch...)
Show SMILES Cc1nc(N)ccc1CNC(=O)c1ccnc(Cc2cc(C#N)c3ncc(Cl)cc3c2)c1
Show InChI InChI=1S/C24H19ClN6O/c1-14-17(2-3-22(27)31-14)12-30-24(32)16-4-5-28-21(10-16)8-15-6-18-9-20(25)13-29-23(18)19(7-15)11-26/h2-7,9-10,13H,8,12H2,1H3,(H2,27,31)(H,30,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283408
PNG
(3-chloro-6-((4-(((5-chloro-1H-indazol-3- yl)methyl...)
Show SMILES NC(=O)c1cc(Cc2cc(ccn2)C(=O)NCc2n[nH]c3ccc(Cl)cc23)cc2cc(Cl)cnc12
Show InChI InChI=1S/C25H18Cl2N6O2/c26-16-1-2-21-19(10-16)22(33-32-21)12-31-25(35)14-3-4-29-18(9-14)6-13-5-15-8-17(27)11-30-23(15)20(7-13)24(28)34/h1-5,7-11H,6,12H2,(H2,28,34)(H,31,35)(H,32,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283416
PNG
(N-((3-chloro-6-fluoro-1H-indol-5-yl)methyl)-2- ((3...)
Show SMILES CS(=O)(=O)c1cc(Cc2cc(ccn2)C(=O)NCc2cc3c(Cl)c[nH]c3cc2F)cc2cc(Cl)cnc12
Show InChI InChI=1S/C26H19Cl2FN4O3S/c1-37(35,36)24-6-14(4-16-7-18(27)12-32-25(16)24)5-19-8-15(2-3-30-19)26(34)33-11-17-9-20-21(28)13-31-23(20)10-22(17)29/h2-4,6-10,12-13,31H,5,11H2,1H3,(H,33,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283423
PNG
(N-((5-chloro-1H-indazol-3-yl)methyl)-2-((8- cyano-...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3n[nH]c4ccc(Cl)cc34)cc2c1)C#N
Show InChI InChI=1S/C26H19ClN6O/c1-15-6-18-7-16(8-19(12-28)25(18)30-13-15)9-21-10-17(4-5-29-21)26(34)31-14-24-22-11-20(27)2-3-23(22)32-33-24/h2-8,10-11,13H,9,14H2,1H3,(H,31,34)(H,32,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283425
PNG
(6-((4-(((6-amino-2,4-dimethylpyridin-3- yl)methyl)...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3c(C)cc(N)nc3C)cc2c1)C(N)=O
Show InChI InChI=1S/C26H26N6O2/c1-14-6-19-8-17(10-21(25(28)33)24(19)30-12-14)9-20-11-18(4-5-29-20)26(34)31-13-22-15(2)7-23(27)32-16(22)3/h4-8,10-12H,9,13H2,1-3H3,(H2,27,32)(H2,28,33)(H,31,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283426
PNG
(6-((4-(((3-chloro-6-fluoro-1H-indol-5- yl)methyl)c...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3cc4c(Cl)c[nH]c4cc3F)cc2c1)C(N)=O
Show InChI InChI=1S/C27H21ClFN5O2/c1-14-4-17-5-15(7-21(26(30)35)25(17)33-11-14)6-19-8-16(2-3-31-19)27(36)34-12-18-9-20-22(28)13-32-24(20)10-23(18)29/h2-5,7-11,13,32H,6,12H2,1H3,(H2,30,35)(H,34,36)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283464
PNG
(N-((3-chloro-6-fluoro-1H-indol-5-yl)methyl)-2- ((6...)
Show SMILES Cc1ccc2ncc(Cc3cc(ccn3)C(=O)NCc3cc4c(Cl)c[nH]c4cc3F)cc2c1
Show InChI InChI=1S/C26H20ClFN4O/c1-15-2-3-24-18(6-15)7-16(12-30-24)8-20-9-17(4-5-29-20)26(33)32-13-19-10-21-22(27)14-31-25(21)11-23(19)28/h2-7,9-12,14,31H,8,13H2,1H3,(H,32,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283476
PNG
(N-((3-chloro-6-fluoro-1H-indol-5-yl)methyl)-2- ((2...)
Show SMILES Cc1ccc2ccc(Cc3cc(ccn3)C(=O)NCc3cc4c(Cl)c[nH]c4cc3F)cc2n1
Show InChI InChI=1S/C26H20ClFN4O/c1-15-2-4-17-5-3-16(9-24(17)32-15)8-20-10-18(6-7-29-20)26(33)31-13-19-11-21-22(27)14-30-25(21)12-23(19)28/h2-7,9-12,14,30H,8,13H2,1H3,(H,31,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283489
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cc2cnc3cc(Cl)ccc3c2)c1
Show InChI InChI=1S/C24H22ClN5O/c1-14-7-23(26)30-15(2)21(14)13-29-24(31)18-5-6-27-20(10-18)9-16-8-17-3-4-19(25)11-22(17)28-12-16/h3-8,10-12H,9,13H2,1-2H3,(H2,26,30)(H,29,31)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283491
PNG
(N-((3-chloro-6-fluoro-1H-indol-5-yl)methyl)-2- ((3...)
Show SMILES Cc1cnc2ccc(Cc3cc(ccn3)C(=O)NCc3cc4c(Cl)c[nH]c4cc3F)cc2c1
Show InChI InChI=1S/C26H20ClFN4O/c1-15-6-18-7-16(2-3-24(18)30-12-15)8-20-9-17(4-5-29-20)26(33)32-13-19-10-21-22(27)14-31-25(21)11-23(19)28/h2-7,9-12,14,31H,8,13H2,1H3,(H,32,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283367
PNG
(N-((3-chloro-1H-pyrrolo[2,3-b]pyridin-5- yl)methyl...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3cnc4[nH]cc(Cl)c4c3)cc2c1)S(C)(=O)=O
Show InChI InChI=1S/C26H22ClN5O3S/c1-15-5-19-6-16(9-23(36(2,34)35)24(19)29-11-15)7-20-10-18(3-4-28-20)26(33)32-13-17-8-21-22(27)14-31-25(21)30-12-17/h3-6,8-12,14H,7,13H2,1-2H3,(H,30,31)(H,32,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283383
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cc2ccc3ncc(Cl)cc3c2)c1
Show InChI InChI=1S/C24H22ClN5O/c1-14-7-23(26)30-15(2)21(14)13-29-24(31)17-5-6-27-20(11-17)9-16-3-4-22-18(8-16)10-19(25)12-28-22/h3-8,10-12H,9,13H2,1-2H3,(H2,26,30)(H,29,31)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283394
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cc2ccc3nc(CN)ccc3c2)c1
Show InChI InChI=1S/C25H26N6O/c1-15-9-24(27)30-16(2)22(15)14-29-25(32)19-7-8-28-21(12-19)11-17-3-6-23-18(10-17)4-5-20(13-26)31-23/h3-10,12H,11,13-14,26H2,1-2H3,(H2,27,30)(H,29,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283428
PNG
(6-((4-(((3-chloro-1H-pyrrolo[2,3-b]pyridin-5- yl)m...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3cnc4[nH]cc(Cl)c4c3)cc2c1)C(N)=O
Show InChI InChI=1S/C26H21ClN6O2/c1-14-4-18-5-15(7-21(24(28)34)23(18)30-10-14)6-19-9-17(2-3-29-19)26(35)33-12-16-8-20-22(27)13-32-25(20)31-11-16/h2-5,7-11,13H,6,12H2,1H3,(H2,28,34)(H,31,32)(H,33,35)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283432
PNG
(6-((4-(((6-amino-2,4-dimethylpyridin-3- yl)methyl)...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3c(C)cc(N)nc3C)cc2c1)C(O)=O
Show InChI InChI=1S/C26H25N5O3/c1-14-6-19-8-17(10-21(26(33)34)24(19)29-12-14)9-20-11-18(4-5-28-20)25(32)30-13-22-15(2)7-23(27)31-16(22)3/h4-8,10-12H,9,13H2,1-3H3,(H2,27,31)(H,30,32)(H,33,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283442
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cc2cc(CO)c3ncc(Cl)cc3c2)c1
Show InChI InChI=1S/C25H24ClN5O2/c1-14-5-23(27)31-15(2)22(14)12-30-25(33)17-3-4-28-21(10-17)8-16-6-18-9-20(26)11-29-24(18)19(7-16)13-32/h3-7,9-11,32H,8,12-13H2,1-2H3,(H2,27,31)(H,30,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283443
PNG
(US10023557, Example 95 | US9611252, Example 95 | m...)
Show SMILES COC(=O)c1cc(Cc2cc(ccn2)C(=O)NCc2ccc(N)nc2C)cc2cc(Cl)cnc12
Show InChI InChI=1S/C25H22ClN5O3/c1-14-17(3-4-22(27)31-14)12-30-24(32)16-5-6-28-20(11-16)8-15-7-18-10-19(26)13-29-23(18)21(9-15)25(33)34-2/h3-7,9-11,13H,8,12H2,1-2H3,(H2,27,31)(H,30,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283447
PNG
(6-((4-(((6-amino-2,4-dimethylpyridin-3- yl)methyl)...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cc2ccc3[n+]([O-])cc(Cl)cc3c2)c1
Show InChI InChI=1S/C24H22ClN5O2/c1-14-7-23(26)29-15(2)21(14)12-28-24(31)17-5-6-27-20(11-17)9-16-3-4-22-18(8-16)10-19(25)13-30(22)32/h3-8,10-11,13H,9,12H2,1-2H3,(H2,26,29)(H,28,31)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283454
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cn2cc3cc(Cl)ccc3n2)c1
Show InChI InChI=1S/C22H21ClN6O/c1-13-7-21(24)27-14(2)19(13)10-26-22(30)15-5-6-25-18(9-15)12-29-11-16-8-17(23)3-4-20(16)28-29/h3-9,11H,10,12H2,1-2H3,(H2,24,27)(H,26,30)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283463
PNG
(N-((1-aminoisoquinolin-6-yl)methyl)-2-((6- methylq...)
Show SMILES Cc1ccc2ncc(Cc3cc(ccn3)C(=O)NCc3ccc4c(N)nccc4c3)cc2c1
Show InChI InChI=1S/C27H23N5O/c1-17-2-5-25-22(10-17)12-19(16-31-25)13-23-14-21(7-8-29-23)27(33)32-15-18-3-4-24-20(11-18)6-9-30-26(24)28/h2-12,14,16H,13,15H2,1H3,(H2,28,30)(H,32,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283472
PNG
(N-((1-aminoisoquinolin-6-yl)methyl)-2-((7- fluoroq...)
Show SMILES Nc1nccc2cc(CNC(=O)c3ccnc(Cc4cnc5cc(F)ccc5c4)c3)ccc12
Show InChI InChI=1S/C26H20FN5O/c27-21-3-2-19-10-17(15-31-24(19)13-21)11-22-12-20(6-7-29-22)26(33)32-14-16-1-4-23-18(9-16)5-8-30-25(23)28/h1-10,12-13,15H,11,14H2,(H2,28,30)(H,32,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283474
PNG
(N-((3-chloro-6-fluoro-1H-indol-5-yl)methyl)-2- ((6...)
Show SMILES Fc1cc2[nH]cc(Cl)c2cc1CNC(=O)c1ccnc(Cc2cnc3ccc(Cl)cc3c2)c1
Show InChI InChI=1S/C25H17Cl2FN4O/c26-18-1-2-23-16(7-18)5-14(11-30-23)6-19-8-15(3-4-29-19)25(33)32-12-17-9-20-21(27)13-31-24(20)10-22(17)28/h1-5,7-11,13,31H,6,12H2,(H,32,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283480
PNG
(N-((1-aminoisoquinolin-6-yl)methyl)-2-((3- methyli...)
Show SMILES Cc1cc2cc(Cc3cc(ccn3)C(=O)NCc3ccc4c(N)nccc4c3)ccc2cn1
Show InChI InChI=1S/C27H23N5O/c1-17-10-23-11-18(2-4-22(23)16-31-17)13-24-14-21(7-8-29-24)27(33)32-15-19-3-5-25-20(12-19)6-9-30-26(25)28/h2-12,14,16H,13,15H2,1H3,(H2,28,30)(H,32,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283351
PNG
(N-((1-aminoisoquinolin-6-yl)methyl)-2-((2- cyanoqu...)
Show SMILES Nc1nccc2cc(CNC(=O)c3ccnc(Cc4ccc5nc(ccc5c4)C#N)c3)ccc12
Show InChI InChI=1S/C27H20N6O/c28-15-22-4-3-20-11-17(2-6-25(20)33-22)13-23-14-21(8-9-30-23)27(34)32-16-18-1-5-24-19(12-18)7-10-31-26(24)29/h1-12,14H,13,16H2,(H2,29,31)(H,32,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283379
PNG
(N-((1-aminoisoquinolin-6-yl)methyl)-2-((3- chloroq...)
Show SMILES Nc1nccc2cc(CNC(=O)c3ccnc(Cc4ccc5ncc(Cl)cc5c4)c3)ccc12
Show InChI InChI=1S/C26H20ClN5O/c27-21-12-20-9-16(2-4-24(20)31-15-21)11-22-13-19(6-7-29-22)26(33)32-14-17-1-3-23-18(10-17)5-8-30-25(23)28/h1-10,12-13,15H,11,14H2,(H2,28,30)(H,32,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283388
PNG
(N-((3-chloro-4-fluoro-1H-indol-5-yl)methyl)-2- ((3...)
Show SMILES Fc1c(CNC(=O)c2ccnc(Cc3ccc4ncc(Cl)cc4c3)c2)ccc2[nH]cc(Cl)c12
Show InChI InChI=1S/C25H17Cl2FN4O/c26-18-9-17-7-14(1-3-21(17)30-12-18)8-19-10-15(5-6-29-19)25(33)32-11-16-2-4-22-23(24(16)28)20(27)13-31-22/h1-7,9-10,12-13,31H,8,11H2,(H,32,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283407
PNG
(3-chloro-6-((4-(((3-chloro-6-fluoro-1H-indol-5- yl...)
Show SMILES NC(=O)c1cc(Cc2cc(ccn2)C(=O)NCc2cc3c(Cl)c[nH]c3cc2F)cc2cc(Cl)cnc12
Show InChI InChI=1S/C26H18Cl2FN5O2/c27-17-6-15-3-13(5-20(25(30)35)24(15)33-11-17)4-18-7-14(1-2-31-18)26(36)34-10-16-8-19-21(28)12-32-23(19)9-22(16)29/h1-3,5-9,11-12,32H,4,10H2,(H2,30,35)(H,34,36)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283420
PNG
(N-((3-chloro-6-fluoro-1H-indol-5-yl)methyl)-2- ((8...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3cc4c(Cl)c[nH]c4cc3F)cc2c1)C#N
Show InChI InChI=1S/C27H19ClFN5O/c1-15-4-18-5-16(6-19(11-30)26(18)33-12-15)7-21-8-17(2-3-31-21)27(35)34-13-20-9-22-23(28)14-32-25(22)10-24(20)29/h2-6,8-10,12,14,32H,7,13H2,1H3,(H,34,35)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283421
PNG
(N-((3-chloro-1H-pyrrolo[2,3-b]pyridin-5- yl)methyl...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3cnc4[nH]cc(Cl)c4c3)cc2c1)C#N
Show InChI InChI=1S/C26H19ClN6O/c1-15-4-19-5-16(6-20(10-28)24(19)30-11-15)7-21-9-18(2-3-29-21)26(34)33-13-17-8-22-23(27)14-32-25(22)31-12-17/h2-6,8-9,11-12,14H,7,13H2,1H3,(H,31,32)(H,33,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283431
PNG
(6-((4-(((6-fluoro-1H-indol-5- yl)methyl)carbamoyl)...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3cc4cc[nH]c4cc3F)cc2c1)C(N)=O
Show InChI InChI=1S/C27H22FN5O2/c1-15-6-19-7-16(9-22(26(29)34)25(19)32-13-15)8-21-11-18(3-4-30-21)27(35)33-14-20-10-17-2-5-31-24(17)12-23(20)28/h2-7,9-13,31H,8,14H2,1H3,(H2,29,34)(H,33,35)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283449
PNG
(N-((6-amino-2-methylpyridin-3-yl)methyl)-2- ((3,8-...)
Show SMILES Cc1nc(N)ccc1CNC(=O)c1ccnc(Cc2cc(Cl)c3ncc(Cl)cc3c2)c1
Show InChI InChI=1S/C23H19Cl2N5O/c1-13-16(2-3-21(26)30-13)11-29-23(31)15-4-5-27-19(10-15)7-14-6-17-9-18(24)12-28-22(17)20(25)8-14/h2-6,8-10,12H,7,11H2,1H3,(H2,26,30)(H,29,31)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283459
PNG
(N-((1-aminoisoquinolin-6-yl)methyl)-2-((2- methylq...)
Show SMILES Cc1ccc2cc(Cc3cc(ccn3)C(=O)NCc3ccc4c(N)nccc4c3)ccc2n1
Show InChI InChI=1S/C27H23N5O/c1-17-2-5-21-12-18(4-7-25(21)32-17)14-23-15-22(9-10-29-23)27(33)31-16-19-3-6-24-20(13-19)8-11-30-26(24)28/h2-13,15H,14,16H2,1H3,(H2,28,30)(H,31,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283466
PNG
(N-((1-aminoisoquinolin-6-yl)methyl)-2-((6- fluoroq...)
Show SMILES Nc1nccc2cc(CNC(=O)c3ccnc(Cc4cnc5ccc(F)cc5c4)c3)ccc12
Show InChI InChI=1S/C26H20FN5O/c27-21-2-4-24-20(12-21)10-17(15-31-24)11-22-13-19(6-7-29-22)26(33)32-14-16-1-3-23-18(9-16)5-8-30-25(23)28/h1-10,12-13,15H,11,14H2,(H2,28,30)(H,32,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283490
PNG
(N-((1-aminoisoquinolin-6-yl)methyl)-2-((3- methylq...)
Show SMILES Cc1cnc2ccc(Cc3cc(ccn3)C(=O)NCc3ccc4c(N)nccc4c3)cc2c1
Show InChI InChI=1S/C27H23N5O/c1-17-10-22-11-18(3-5-25(22)31-15-17)13-23-14-21(7-8-29-23)27(33)32-16-19-2-4-24-20(12-19)6-9-30-26(24)28/h2-12,14-15H,13,16H2,1H3,(H2,28,30)(H,32,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283492
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cnc2ccc(Cc3cc(ccn3)C(=O)NCc3c(C)cc(N)nc3C)cc2c1
Show InChI InChI=1S/C25H25N5O/c1-15-8-20-10-18(4-5-23(20)28-13-15)11-21-12-19(6-7-27-21)25(31)29-14-22-16(2)9-24(26)30-17(22)3/h4-10,12-13H,11,14H2,1-3H3,(H2,26,30)(H,29,31)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283354
PNG
(N-((1-aminoisoquinolin-6-yl)methyl)-2-((3- cyanoqu...)
Show SMILES Nc1nccc2cc(CNC(=O)c3ccnc(Cc4ccc5ncc(cc5c4)[N+]#[C-])c3)ccc12
Show InChI InChI=1S/C27H20N6O/c1-29-23-14-21-10-17(3-5-25(21)32-16-23)12-22-13-20(7-8-30-22)27(34)33-15-18-2-4-24-19(11-18)6-9-31-26(24)28/h2-11,13-14,16H,12,15H2,(H2,28,31)(H,33,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283386
PNG
(N-((3-chloro-1H-pyrrolo[2,3-b]pyridin-5- yl)methyl...)
Show SMILES Clc1c[nH]c2ncc(CNC(=O)c3ccnc(Cc4ccc5ncc(Cl)cc5c4)c3)cc12
Show InChI InChI=1S/C24H17Cl2N5O/c25-18-8-17-5-14(1-2-22(17)28-12-18)6-19-9-16(3-4-27-19)24(32)31-11-15-7-20-21(26)13-30-23(20)29-10-15/h1-5,7-10,12-13H,6,11H2,(H,29,30)(H,31,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283409
PNG
(3-chloro-6-((4-(((3-chloro-1H-pyrrolo[2,3- b]pyrid...)
Show SMILES NC(=O)c1cc(Cc2cc(ccn2)C(=O)NCc2cnc3[nH]cc(Cl)c3c2)cc2cc(Cl)cnc12
Show InChI InChI=1S/C25H18Cl2N6O2/c26-17-7-16-3-13(5-20(23(28)34)22(16)30-11-17)4-18-8-15(1-2-29-18)25(35)33-10-14-6-19-21(27)12-32-24(19)31-9-14/h1-3,5-9,11-12H,4,10H2,(H2,28,34)(H,31,32)(H,33,35)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283413
PNG
(3-chloro-6-((4-(((3-chloro-4-fluoro-1H-indol-5- yl...)
Show SMILES NC(=O)c1cc(Cc2cc(ccn2)C(=O)NCc2ccc3[nH]cc(Cl)c3c2F)cc2cc(Cl)cnc12
Show InChI InChI=1S/C26H18Cl2FN5O2/c27-17-8-16-5-13(7-19(25(30)35)24(16)33-11-17)6-18-9-14(3-4-31-18)26(36)34-10-15-1-2-21-22(23(15)29)20(28)12-32-21/h1-5,7-9,11-12,32H,6,10H2,(H2,30,35)(H,34,36)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283422
PNG
(N-((3-chloro-4-fluoro-1H-indol-5-yl)methyl)-2- ((8...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3ccc4[nH]cc(Cl)c4c3F)cc2c1)C#N
Show InChI InChI=1S/C27H19ClFN5O/c1-15-6-19-7-16(8-20(11-30)26(19)33-12-15)9-21-10-17(4-5-31-21)27(35)34-13-18-2-3-23-24(25(18)29)22(28)14-32-23/h2-8,10,12,14,32H,9,13H2,1H3,(H,34,35)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283427
PNG
(6-((4-(((1-aminoisoquinolin-6- yl)methyl)carbamoyl...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3ccc4c(N)nccc4c3)cc2c1)C(N)=O
Show InChI InChI=1S/C28H24N6O2/c1-16-8-21-10-18(12-24(27(30)35)25(21)33-14-16)11-22-13-20(5-6-31-22)28(36)34-15-17-2-3-23-19(9-17)4-7-32-26(23)29/h2-10,12-14H,11,15H2,1H3,(H2,29,32)(H2,30,35)(H,34,36)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283439
PNG
(N-((6-amino-2-methylpyridin-3-yl)methyl)-2- ((3-ch...)
Show SMILES Cc1nc(N)ccc1CNC(=O)c1ccnc(Cc2cc(F)c3ncc(Cl)cc3c2)c1
Show InChI InChI=1S/C23H19ClFN5O/c1-13-16(2-3-21(26)30-13)11-29-23(31)15-4-5-27-19(10-15)7-14-6-17-9-18(24)12-28-22(17)20(25)8-14/h2-6,8-10,12H,7,11H2,1H3,(H2,26,30)(H,29,31)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283441
PNG
(6-((4-(((6-amino-2,4-dimethylpyridin-3- yl)methyl)...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cc2cc(C(O)=O)c3ncc(Cl)cc3c2)c1
Show InChI InChI=1S/C25H22ClN5O3/c1-13-5-22(27)31-14(2)21(13)12-30-24(32)16-3-4-28-19(10-16)7-15-6-17-9-18(26)11-29-23(17)20(8-15)25(33)34/h3-6,8-11H,7,12H2,1-2H3,(H2,27,31)(H,30,32)(H,33,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283448
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cc2cc(Cl)c3ncc(Cl)cc3c2)c1
Show InChI InChI=1S/C24H21Cl2N5O/c1-13-5-22(27)31-14(2)20(13)12-30-24(32)16-3-4-28-19(10-16)7-15-6-17-9-18(25)11-29-23(17)21(26)8-15/h3-6,8-11H,7,12H2,1-2H3,(H2,27,31)(H,30,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283451
PNG
(N-((6-amino-2-methylpyridin-3-yl)methyl)-2- ((3-ch...)
Show SMILES Cc1nc(N)ccc1CNC(=O)c1ccnc(Cc2ccc3ncc(Cl)cc3c2F)c1
Show InChI InChI=1S/C23H19ClFN5O/c1-13-16(3-5-21(26)30-13)11-29-23(31)15-6-7-27-18(9-15)8-14-2-4-20-19(22(14)25)10-17(24)12-28-20/h2-7,9-10,12H,8,11H2,1H3,(H2,26,30)(H,29,31)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283549
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cn2ncc3cc(Cl)ccc23)c1
Show InChI InChI=1S/C22H21ClN6O/c1-13-7-21(24)28-14(2)19(13)11-26-22(30)15-5-6-25-18(9-15)12-29-20-4-3-17(23)8-16(20)10-27-29/h3-10H,11-12H2,1-2H3,(H2,24,28)(H,26,30)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283456
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1ccc2n(Cc3cc(ccn3)C(=O)NCc3c(C)cc(N)nc3C)ncc2c1
Show InChI InChI=1S/C23H24N6O/c1-14-4-5-21-18(8-14)11-27-29(21)13-19-10-17(6-7-25-19)23(30)26-12-20-15(2)9-22(24)28-16(20)3/h4-11H,12-13H2,1-3H3,(H2,24,28)(H,26,30)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283465
PNG
(N-((6-amino-2-methylpyridin-3-yl)methyl)-2- ((6-me...)
Show SMILES Cc1ccc2ncc(Cc3cc(ccn3)C(=O)NCc3ccc(N)nc3C)cc2c1
Show InChI InChI=1S/C24H23N5O/c1-15-3-5-22-20(9-15)10-17(13-27-22)11-21-12-18(7-8-26-21)24(30)28-14-19-4-6-23(25)29-16(19)2/h3-10,12-13H,11,14H2,1-2H3,(H2,25,29)(H,28,30)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283473
PNG
(N-((3-chloro-6-fluoro-1H-indol-5-yl)methyl)-2- (qu...)
Show SMILES Fc1cc2[nH]cc(Cl)c2cc1CNC(=O)c1ccnc(Cc2cnc3ccccc3c2)c1
Show InChI InChI=1S/C25H18ClFN4O/c26-21-14-30-24-11-22(27)18(10-20(21)24)13-31-25(32)17-5-6-28-19(9-17)8-15-7-16-3-1-2-4-23(16)29-12-15/h1-7,9-12,14,30H,8,13H2,(H,31,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283481
PNG
(N-((3-chloro-6-fluoro-1H-indol-5-yl)methyl)-2- ((3...)
Show SMILES Cc1cc2cc(Cc3cc(ccn3)C(=O)NCc3cc4c(Cl)c[nH]c4cc3F)ccc2cn1
Show InChI InChI=1S/C26H20ClFN4O/c1-15-6-19-7-16(2-3-18(19)12-30-15)8-21-9-17(4-5-29-21)26(33)32-13-20-10-22-23(27)14-31-25(22)11-24(20)28/h2-7,9-12,14,31H,8,13H2,1H3,(H,32,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283484
PNG
(N-((1-aminoisoquinolin-6-yl)methyl)-2-((4- cyanoqu...)
Show SMILES Nc1nccc2cc(CNC(=O)c3ccnc(Cc4ccc5nccc([N+]#[C-])c5c4)c3)ccc12
Show InChI InChI=1S/C27H20N6O/c1-29-24-8-11-31-25-5-3-17(14-23(24)25)13-21-15-20(7-9-30-21)27(34)33-16-18-2-4-22-19(12-18)6-10-32-26(22)28/h2-12,14-15H,13,16H2,(H2,28,32)(H,33,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283486
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cc2ccc3nccc([N+]#[C-])c3c2)c1
Show InChI InChI=1S/C25H22N6O/c1-15-10-24(26)31-16(2)21(15)14-30-25(32)18-6-8-28-19(13-18)11-17-4-5-23-20(12-17)22(27-3)7-9-29-23/h4-10,12-13H,11,14H2,1-2H3,(H2,26,31)(H,30,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283363
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3c(C)cc(N)nc3C)cc2c1)S(C)(=O)=O
Show InChI InChI=1S/C26H27N5O3S/c1-15-7-20-9-18(11-23(35(4,33)34)25(20)29-13-15)10-21-12-19(5-6-28-21)26(32)30-14-22-16(2)8-24(27)31-17(22)3/h5-9,11-13H,10,14H2,1-4H3,(H2,27,31)(H,30,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283365
PNG
(N-((3-chloro-6-fluoro-1H-indol-5-yl)methyl)-2- ((3...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3cc4c(Cl)c[nH]c4cc3F)cc2c1)S(C)(=O)=O
Show InChI InChI=1S/C27H22ClFN4O3S/c1-15-5-18-6-16(8-25(37(2,35)36)26(18)32-12-15)7-20-9-17(3-4-30-20)27(34)33-13-19-10-21-22(28)14-31-24(21)11-23(19)29/h3-6,8-12,14,31H,7,13H2,1-2H3,(H,33,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283377
PNG
(N-((6-amino-4-methylpyridin-3-yl)methyl)-2- ((3-ch...)
Show SMILES Cc1cc(N)ncc1CNC(=O)c1ccnc(Cc2ccc3ncc(Cl)cc3c2)c1
Show InChI InChI=1S/C23H20ClN5O/c1-14-6-22(25)28-11-18(14)12-29-23(30)16-4-5-26-20(10-16)8-15-2-3-21-17(7-15)9-19(24)13-27-21/h2-7,9-11,13H,8,12H2,1H3,(H2,25,28)(H,29,30)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283402
PNG
(N-((5-chloro-1H-indazol-3-yl)methyl)-2-((3- chloro...)
Show SMILES Clc1ccc2[nH]nc(CNC(=O)c3ccnc(Cc4cc(C#N)c5ncc(Cl)cc5c4)c3)c2c1
Show InChI InChI=1S/C25H16Cl2N6O/c26-18-1-2-22-21(10-18)23(33-32-22)13-31-25(34)15-3-4-29-20(9-15)7-14-5-16-8-19(27)12-30-24(16)17(6-14)11-28/h1-6,8-10,12H,7,13H2,(H,31,34)(H,32,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283419
PNG
(N-((1-aminoisoquinolin-6-yl)methyl)-2-((8- cyano-3...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3ccc4c(N)nccc4c3)cc2c1)C#N
Show InChI InChI=1S/C28H22N6O/c1-17-8-22-10-19(11-23(14-29)26(22)33-15-17)12-24-13-21(5-6-31-24)28(35)34-16-18-2-3-25-20(9-18)4-7-32-27(25)30/h2-11,13,15H,12,16H2,1H3,(H2,30,32)(H,34,35)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283429
PNG
(6-((4-(((3-chloro-4-fluoro-1H-indol-5- yl)methyl)c...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3ccc4[nH]cc(Cl)c4c3F)cc2c1)C(N)=O
Show InChI InChI=1S/C27H21ClFN5O2/c1-14-6-18-7-15(9-20(26(30)35)25(18)33-11-14)8-19-10-16(4-5-31-19)27(36)34-12-17-2-3-22-23(24(17)29)21(28)13-32-22/h2-7,9-11,13,32H,8,12H2,1H3,(H2,30,35)(H,34,36)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283437
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cc2cc(F)c3ncc(Cl)cc3c2)c1
Show InChI InChI=1S/C24H21ClFN5O/c1-13-5-22(27)31-14(2)20(13)12-30-24(32)16-3-4-28-19(10-16)7-15-6-17-9-18(25)11-29-23(17)21(26)8-15/h3-6,8-11H,7,12H2,1-2H3,(H2,27,31)(H,30,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283440
PNG
(US10023557, Example 92 | US9611252, Example 92 | m...)
Show SMILES COC(=O)c1cc(Cc2cc(ccn2)C(=O)NCc2c(C)cc(N)nc2C)cc2cc(Cl)cnc12
Show InChI InChI=1S/C26H24ClN5O3/c1-14-6-23(28)32-15(2)22(14)13-31-25(33)17-4-5-29-20(11-17)8-16-7-18-10-19(27)12-30-24(18)21(9-16)26(34)35-3/h4-7,9-12H,8,13H2,1-3H3,(H2,28,32)(H,31,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283450
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cc2ccc3ncc(Cl)cc3c2F)c1
Show InChI InChI=1S/C24H21ClFN5O/c1-13-7-22(27)31-14(2)20(13)12-30-24(32)16-5-6-28-18(9-16)8-15-3-4-21-19(23(15)26)10-17(25)11-29-21/h3-7,9-11H,8,12H2,1-2H3,(H2,27,31)(H,30,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283460
PNG
(N-((6-amino-2-methylpyridin-3-yl)methyl)-2- ((2-me...)
Show SMILES Cc1ccc2cc(Cc3cc(ccn3)C(=O)NCc3ccc(N)nc3C)ccc2n1
Show InChI InChI=1S/C24H23N5O/c1-15-3-5-18-11-17(4-7-22(18)28-15)12-21-13-19(9-10-26-21)24(30)27-14-20-6-8-23(25)29-16(20)2/h3-11,13H,12,14H2,1-2H3,(H2,25,29)(H,27,30)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283471
PNG
(N-((3-chloro-6-fluoro-1H-indol-5-yl)methyl)-2- ((7...)
Show SMILES Fc1ccc2cc(Cc3cc(ccn3)C(=O)NCc3cc4c(Cl)c[nH]c4cc3F)cnc2c1
Show InChI InChI=1S/C25H17ClF2N4O/c26-21-13-31-24-10-22(28)17(8-20(21)24)12-32-25(33)16-3-4-29-19(7-16)6-14-5-15-1-2-18(27)9-23(15)30-11-14/h1-5,7-11,13,31H,6,12H2,(H,32,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283475
PNG
(N-((1-aminoisoquinolin-6-yl)methyl)-2-((2- methylq...)
Show SMILES Cc1ccc2ccc(Cc3cc(ccn3)C(=O)NCc3ccc4c(N)nccc4c3)cc2n1
Show InChI InChI=1S/C27H23N5O/c1-17-2-5-20-6-3-18(14-25(20)32-17)13-23-15-22(9-10-29-23)27(33)31-16-19-4-7-24-21(12-19)8-11-30-26(24)28/h2-12,14-15H,13,16H2,1H3,(H2,28,30)(H,31,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283493
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cc2cc(Cc3cc(ccn3)C(=O)NCc3c(C)cc(N)nc3C)ccc2cn1
Show InChI InChI=1S/C25H25N5O/c1-15-8-24(26)30-17(3)23(15)14-29-25(31)19-6-7-27-22(12-19)11-18-4-5-20-13-28-16(2)9-21(20)10-18/h4-10,12-13H,11,14H2,1-3H3,(H2,26,30)(H,29,31)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283364
PNG
(N-((1-aminoisoquinolin-6-yl)methyl)-2-((3- methyl-...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3ccc4c(N)nccc4c3)cc2c1)S(C)(=O)=O
Show InChI InChI=1S/C28H25N5O3S/c1-17-9-22-11-19(13-25(37(2,35)36)26(22)32-15-17)12-23-14-21(6-7-30-23)28(34)33-16-18-3-4-24-20(10-18)5-8-31-27(24)29/h3-11,13-15H,12,16H2,1-2H3,(H2,29,31)(H,33,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283385
PNG
(N-((5-chloro-1H-indazol-3-yl)methyl)-2-((3- chloro...)
Show SMILES Clc1ccc2[nH]nc(CNC(=O)c3ccnc(Cc4ccc5ncc(Cl)cc5c4)c3)c2c1
Show InChI InChI=1S/C24H17Cl2N5O/c25-17-2-4-22-20(11-17)23(31-30-22)13-29-24(32)15-5-6-27-19(10-15)8-14-1-3-21-16(7-14)9-18(26)12-28-21/h1-7,9-12H,8,13H2,(H,29,32)(H,30,31)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283382
PNG
(N-((6-amino-2-methylpyridin-3-yl)methyl)-2- ((3-ch...)
Show SMILES Cc1nc(N)ccc1CNC(=O)c1ccnc(Cc2ccc3ncc(Cl)cc3c2)c1
Show InChI InChI=1S/C23H20ClN5O/c1-14-17(3-5-22(25)29-14)12-28-23(30)16-6-7-26-20(11-16)9-15-2-4-21-18(8-15)10-19(24)13-27-21/h2-8,10-11,13H,9,12H2,1H3,(H2,25,29)(H,28,30)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283400
PNG
(2-((3-chloro-8-cyanoquinolin-6-yl)methyl)-N- ((6-f...)
Show SMILES Fc1cc2[nH]ccc2cc1CNC(=O)c1ccnc(Cc2cc(C#N)c3ncc(Cl)cc3c2)c1
Show InChI InChI=1S/C26H17ClFN5O/c27-21-9-18-5-15(6-19(12-29)25(18)32-14-21)7-22-10-17(2-3-30-22)26(34)33-13-20-8-16-1-4-31-24(16)11-23(20)28/h1-6,8-11,14,31H,7,13H2,(H,33,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283406
PNG
(6-((4-(((6-amino-2,4-dimethylpyridin-3- yl)methyl)...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cc2cc(C(N)=O)c3ncc(Cl)cc3c2)c1
Show InChI InChI=1S/C25H23ClN6O2/c1-13-5-22(27)32-14(2)21(13)12-31-25(34)16-3-4-29-19(10-16)7-15-6-17-9-18(26)11-30-23(17)20(8-15)24(28)33/h3-6,8-11H,7,12H2,1-2H3,(H2,27,32)(H2,28,33)(H,31,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283417
PNG
(N-((6-amino-2-methylpyridin-3-yl)methyl)-2- ((3-ch...)
Show SMILES Cc1nc(N)ccc1CNC(=O)c1ccnc(Cc2cc(c3ncc(Cl)cc3c2)S(C)(=O)=O)c1
Show InChI InChI=1S/C24H22ClN5O3S/c1-14-17(3-4-22(26)30-14)12-29-24(31)16-5-6-27-20(11-16)8-15-7-18-10-19(25)13-28-23(18)21(9-15)34(2,32)33/h3-7,9-11,13H,8,12H2,1-2H3,(H2,26,30)(H,29,31)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283438
PNG
(N-((3-chloro-6-fluoro-1H-indol-5-yl)methyl)-2- ((3...)
Show SMILES Fc1cc2[nH]cc(Cl)c2cc1CNC(=O)c1ccnc(Cc2cc(F)c3ncc(Cl)cc3c2)c1
Show InChI InChI=1S/C25H16Cl2F2N4O/c26-17-6-15-3-13(5-22(29)24(15)32-11-17)4-18-7-14(1-2-30-18)25(34)33-10-16-8-19-20(27)12-31-23(19)9-21(16)28/h1-3,5-9,11-12,31H,4,10H2,(H,33,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283458
PNG
(N-((3-chloro-6-fluoro-1H-indol-5-yl)methyl)-2- ((2...)
Show SMILES Cc1ccc2cc(Cc3cc(ccn3)C(=O)NCc3cc4c(Cl)c[nH]c4cc3F)ccc2n1
Show InChI InChI=1S/C26H20ClFN4O/c1-15-2-4-17-8-16(3-5-24(17)32-15)9-20-10-18(6-7-29-20)26(33)31-13-19-11-21-22(27)14-30-25(21)12-23(19)28/h2-8,10-12,14,30H,9,13H2,1H3,(H,31,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283467
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cc2cnc3ccc(F)cc3c2)c1
Show InChI InChI=1S/C24H22FN5O/c1-14-7-23(26)30-15(2)21(14)13-29-24(31)17-5-6-27-20(11-17)9-16-8-18-10-19(25)3-4-22(18)28-12-16/h3-8,10-12H,9,13H2,1-2H3,(H2,26,30)(H,29,31)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283469
PNG
(N-((6-amino-2-methylpyridin-3-yl)methyl)-2- ((6-fl...)
Show SMILES Cc1nc(N)ccc1CNC(=O)c1ccnc(Cc2cnc3ccc(F)cc3c2)c1
Show InChI InChI=1S/C23H20FN5O/c1-14-17(2-5-22(25)29-14)13-28-23(30)16-6-7-26-20(11-16)9-15-8-18-10-19(24)3-4-21(18)27-12-15/h2-8,10-12H,9,13H2,1H3,(H2,25,29)(H,28,30)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283478
PNG
(N-((3-chloro-6-fluoro-1H-indol-5-yl)methyl)-2- ((2...)
Show SMILES Fc1cc2[nH]cc(Cl)c2cc1CNC(=O)c1ccnc(Cc2ccc3nc(ccc3c2)[N+]#[C-])c1
Show InChI InChI=1S/C26H17ClFN5O/c1-29-25-5-3-16-8-15(2-4-23(16)33-25)9-19-10-17(6-7-30-19)26(34)32-13-18-11-20-21(27)14-31-24(20)12-22(18)28/h2-8,10-12,14,31H,9,13H2,(H,32,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM314643
PNG
(N-((1-aminoisoquinolin-6-yl)methyl)-2-((7- chloroq...)
Show SMILES Nc1nccc2cc(CNC(=O)c3ccnc(Cc4cnc5cc(ccc5c4)C#N)c3)ccc12
Show InChI InChI=1S/C27H20N6O/c28-14-17-1-3-21-10-19(16-32-25(21)12-17)11-23-13-22(6-7-30-23)27(34)33-15-18-2-4-24-20(9-18)5-8-31-26(24)29/h1-10,12-13,16H,11,15H2,(H2,29,31)(H,33,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283353
PNG
(N-((3-chloro-6-fluoro-1H-indol-5-yl)methyl)-2- ((3...)
Show SMILES Fc1cc2[nH]cc(Cl)c2cc1CNC(=O)c1ccnc(Cc2ccc3ncc(cc3c2)[N+]#[C-])c1
Show InChI InChI=1S/C26H17ClFN5O/c1-29-20-9-17-6-15(2-3-24(17)31-13-20)7-19-8-16(4-5-30-19)26(34)33-12-18-10-21-22(27)14-32-25(21)11-23(18)28/h2-6,8-11,13-14,32H,7,12H2,(H,33,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283355
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cc2ccc3ncc(cc3c2)[N+]#[C-])c1
Show InChI InChI=1S/C25H22N6O/c1-15-8-24(26)31-16(2)22(15)14-30-25(32)18-6-7-28-20(11-18)10-17-4-5-23-19(9-17)12-21(27-3)13-29-23/h4-9,11-13H,10,14H2,1-2H3,(H2,26,31)(H,30,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283382
PNG
(N-((6-amino-2-methylpyridin-3-yl)methyl)-2- ((3-ch...)
Show SMILES Cc1nc(N)ccc1CNC(=O)c1ccnc(Cc2ccc3ncc(Cl)cc3c2)c1
Show InChI InChI=1S/C23H20ClN5O/c1-14-17(3-5-22(25)29-14)12-28-23(30)16-6-7-26-20(11-16)9-15-2-4-21-18(8-15)10-19(24)13-27-21/h2-8,10-11,13H,9,12H2,1H3,(H2,25,29)(H,28,30)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283405
PNG
(N-((1-aminoisoquinolin-6-yl)methyl)-2-((3- chloro-...)
Show SMILES Nc1nccc2cc(CNC(=O)c3ccnc(Cc4cc(C#N)c5ncc(Cl)cc5c4)c3)ccc12
Show InChI InChI=1S/C27H19ClN6O/c28-22-11-20-8-17(9-21(13-29)25(20)33-15-22)10-23-12-19(4-5-31-23)27(35)34-14-16-1-2-24-18(7-16)3-6-32-26(24)30/h1-9,11-12,15H,10,14H2,(H2,30,32)(H,34,35)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283410
PNG
(6-((4-(((6-amino-2-methylpyridin-3- yl)methyl)carb...)
Show SMILES Cc1nc(N)ccc1CNC(=O)c1ccnc(Cc2cc(C(N)=O)c3ncc(Cl)cc3c2)c1
Show InChI InChI=1S/C24H21ClN6O2/c1-13-16(2-3-21(26)31-13)11-30-24(33)15-4-5-28-19(10-15)7-14-6-17-9-18(25)12-29-22(17)20(8-14)23(27)32/h2-6,8-10,12H,7,11H2,1H3,(H2,26,31)(H2,27,32)(H,30,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283411
PNG
(6-((4-(((6-amino-4-methylpyridin-3- yl)methyl)carb...)
Show SMILES Cc1cc(N)ncc1CNC(=O)c1ccnc(Cc2cc(C(N)=O)c3ncc(Cl)cc3c2)c1
Show InChI InChI=1S/C24H21ClN6O2/c1-13-4-21(26)29-10-17(13)11-31-24(33)15-2-3-28-19(9-15)6-14-5-16-8-18(25)12-30-22(16)20(7-14)23(27)32/h2-5,7-10,12H,6,11H2,1H3,(H2,26,29)(H2,27,32)(H,31,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283412
PNG
(6-((4-(((1-aminoisoquinolin-6- yl)methyl)carbamoyl...)
Show SMILES NC(=O)c1cc(Cc2cc(ccn2)C(=O)NCc2ccc3c(N)nccc3c2)cc2cc(Cl)cnc12
Show InChI InChI=1S/C27H21ClN6O2/c28-20-11-19-8-16(10-23(26(30)35)24(19)33-14-20)9-21-12-18(4-5-31-21)27(36)34-13-15-1-2-22-17(7-15)3-6-32-25(22)29/h1-8,10-12,14H,9,13H2,(H2,29,32)(H2,30,35)(H,34,36)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283415
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cc2cc(c3ncc(Cl)cc3c2)S(C)(=O)=O)c1
Show InChI InChI=1S/C25H24ClN5O3S/c1-14-6-23(27)31-15(2)21(14)13-30-25(32)17-4-5-28-20(11-17)8-16-7-18-10-19(26)12-29-24(18)22(9-16)35(3,33)34/h4-7,9-12H,8,13H2,1-3H3,(H2,27,31)(H,30,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283424
PNG
(2-((8-cyano-3-methylquinolin-6-yl)methyl)-N- ((6-f...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3cc4cc[nH]c4cc3F)cc2c1)C#N
Show InChI InChI=1S/C27H20FN5O/c1-16-6-20-7-17(8-21(13-29)26(20)32-14-16)9-23-11-19(3-4-30-23)27(34)33-15-22-10-18-2-5-31-25(18)12-24(22)28/h2-8,10-12,14,31H,9,15H2,1H3,(H,33,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283430
PNG
(6-((4-(((5-chloro-1H-indazol-3- yl)methyl)carbamoy...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3n[nH]c4ccc(Cl)cc34)cc2c1)C(N)=O
Show InChI InChI=1S/C26H21ClN6O2/c1-14-6-17-7-15(9-21(25(28)34)24(17)30-12-14)8-19-10-16(4-5-29-19)26(35)31-13-23-20-11-18(27)2-3-22(20)32-33-23/h2-7,9-12H,8,13H2,1H3,(H2,28,34)(H,31,35)(H,32,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283452
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cc(cc(Cc2ccc3ncc(Cl)cc3c2)n1)C(=O)NCc1c(C)cc(N)nc1C
Show InChI InChI=1S/C25H24ClN5O/c1-14-6-24(27)31-16(3)22(14)13-29-25(32)19-7-15(2)30-21(11-19)9-17-4-5-23-18(8-17)10-20(26)12-28-23/h4-8,10-12H,9,13H2,1-3H3,(H2,27,31)(H,29,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283462
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1ccc2ncc(Cc3cc(ccn3)C(=O)NCc3c(C)cc(N)nc3C)cc2c1
Show InChI InChI=1S/C25H25N5O/c1-15-4-5-23-20(8-15)10-18(13-28-23)11-21-12-19(6-7-27-21)25(31)29-14-22-16(2)9-24(26)30-17(22)3/h4-10,12-13H,11,14H2,1-3H3,(H2,26,30)(H,29,31)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283470
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cc2cnc3cc(F)ccc3c2)c1
Show InChI InChI=1S/C24H22FN5O/c1-14-7-23(26)30-15(2)21(14)13-29-24(31)18-5-6-27-20(10-18)9-16-8-17-3-4-19(25)11-22(17)28-12-16/h3-8,10-12H,9,13H2,1-2H3,(H2,26,30)(H,29,31)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283488
PNG
(N-((3-chloro-6-fluoro-1H-indol-5-yl)methyl)-2- ((7...)
Show SMILES Fc1cc2[nH]cc(Cl)c2cc1CNC(=O)c1ccnc(Cc2cnc3cc(Cl)ccc3c2)c1
Show InChI InChI=1S/C25H17Cl2FN4O/c26-18-2-1-15-5-14(11-30-23(15)9-18)6-19-7-16(3-4-29-19)25(33)32-12-17-8-20-21(27)13-31-24(20)10-22(17)28/h1-5,7-11,13,31H,6,12H2,(H,32,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283366
PNG
(N-((6-fluoro-1H-indol-5-yl)methyl)-2-((3- methyl-8...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3cc4cc[nH]c4cc3F)cc2c1)S(C)(=O)=O
Show InChI InChI=1S/C27H23FN4O3S/c1-16-7-20-8-17(10-25(36(2,34)35)26(20)31-14-16)9-22-12-19(4-5-29-22)27(33)32-15-21-11-18-3-6-30-24(18)13-23(21)28/h3-8,10-14,30H,9,15H2,1-2H3,(H,32,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283369
PNG
(N-((3-chloro-4-fluoro-1H-indol-5-yl)methyl)-2- ((3...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3ccc4[nH]cc(Cl)c4c3F)cc2c1)S(C)(=O)=O
Show InChI InChI=1S/C27H22ClFN4O3S/c1-15-7-19-8-16(10-23(37(2,35)36)26(19)32-12-15)9-20-11-17(5-6-30-20)27(34)33-13-18-3-4-22-24(25(18)29)21(28)14-31-22/h3-8,10-12,14,31H,9,13H2,1-2H3,(H,33,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283389
PNG
(2-((3-chloroquinolin-6-yl)methyl)-N-((6-fluoro- 1H...)
Show SMILES Fc1cc2[nH]ccc2cc1CNC(=O)c1ccnc(Cc2ccc3ncc(Cl)cc3c2)c1
Show InChI InChI=1S/C25H18ClFN4O/c26-20-10-18-7-15(1-2-23(18)30-14-20)8-21-11-17(4-5-28-21)25(32)31-13-19-9-16-3-6-29-24(16)12-22(19)27/h1-7,9-12,14,29H,8,13H2,(H,31,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283397
PNG
(N-((3-chloro-6-fluoro-1H-indol-5-yl)methyl)-2- ((3...)
Show SMILES Fc1cc2[nH]cc(Cl)c2cc1CNC(=O)c1ccnc(Cc2cc(C#N)c3ncc(Cl)cc3c2)c1
Show InChI InChI=1S/C26H16Cl2FN5O/c27-19-6-16-3-14(4-17(10-30)25(16)33-12-19)5-20-7-15(1-2-31-20)26(35)34-11-18-8-21-22(28)13-32-24(21)9-23(18)29/h1-4,6-9,12-13,32H,5,11H2,(H,34,35)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283403
PNG
(N-((3-chloro-1H-pyrrolo[2,3-b]pyridin-5- yl)methyl...)
Show SMILES Clc1c[nH]c2ncc(CNC(=O)c3ccnc(Cc4cc(C#N)c5ncc(Cl)cc5c4)c3)cc12
Show InChI InChI=1S/C25H16Cl2N6O/c26-19-7-17-3-14(4-18(9-28)23(17)30-12-19)5-20-8-16(1-2-29-20)25(34)33-11-15-6-21-22(27)13-32-24(21)31-10-15/h1-4,6-8,10,12-13H,5,11H2,(H,31,32)(H,33,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283414
PNG
(3-chloro-6-((4-(((6-fluoro-1H-indol-5- yl)methyl)c...)
Show SMILES NC(=O)c1cc(Cc2cc(ccn2)C(=O)NCc2cc3cc[nH]c3cc2F)cc2cc(Cl)cnc12
Show InChI InChI=1S/C26H19ClFN5O2/c27-19-9-17-5-14(7-21(25(29)34)24(17)32-13-19)6-20-10-16(2-3-30-20)26(35)33-12-18-8-15-1-4-31-23(15)11-22(18)28/h1-5,7-11,13,31H,6,12H2,(H2,29,34)(H,33,35)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283418
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3c(C)cc(N)nc3C)cc2c1)C#N
Show InChI InChI=1S/C26H24N6O/c1-15-6-20-8-18(9-21(12-27)25(20)30-13-15)10-22-11-19(4-5-29-22)26(33)31-14-23-16(2)7-24(28)32-17(23)3/h4-9,11,13H,10,14H2,1-3H3,(H2,28,32)(H,31,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283445
PNG
(N-((6-amino-2-methylpyridin-3-yl)methyl)-2- ((3-ch...)
Show SMILES Cc1nc(N)ccc1CNC(=O)c1ccnc(Cc2cc(CO)c3ncc(Cl)cc3c2)c1
Show InChI InChI=1S/C24H22ClN5O2/c1-14-17(2-3-22(26)30-14)11-29-24(32)16-4-5-27-21(10-16)8-15-6-18-9-20(25)12-28-23(18)19(7-15)13-31/h2-7,9-10,12,31H,8,11,13H2,1H3,(H2,26,30)(H,29,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283461
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1ccc2cc(Cc3cc(ccn3)C(=O)NCc3c(C)cc(N)nc3C)ccc2n1
Show InChI InChI=1S/C25H25N5O/c1-15-10-24(26)30-17(3)22(15)14-28-25(31)20-8-9-27-21(13-20)12-18-5-7-23-19(11-18)6-4-16(2)29-23/h4-11,13H,12,14H2,1-3H3,(H2,26,30)(H,28,31)
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US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283468
PNG
(N-((3-chloro-6-fluoro-1H-indol-5-yl)methyl)-2- ((6...)
Show SMILES Fc1ccc2ncc(Cc3cc(ccn3)C(=O)NCc3cc4c(Cl)c[nH]c4cc3F)cc2c1
Show InChI InChI=1S/C25H17ClF2N4O/c26-21-13-31-24-10-22(28)17(9-20(21)24)12-32-25(33)15-3-4-29-19(8-15)6-14-5-16-7-18(27)1-2-23(16)30-11-14/h1-5,7-11,13,31H,6,12H2,(H,32,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283479
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cc2ccc3nc(ccc3c2)[N+]#[C-])c1
Show InChI InChI=1S/C25H22N6O/c1-15-10-23(26)30-16(2)21(15)14-29-25(32)19-8-9-28-20(13-19)12-17-4-6-22-18(11-17)5-7-24(27-3)31-22/h4-11,13H,12,14H2,1-2H3,(H2,26,30)(H,29,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283360
PNG
(N-((3-chloro-6-fluoro-1H-indol-5-yl)methyl)-2- ((6...)
Show SMILES CS(=O)(=O)c1ccc2ncc(Cc3cc(ccn3)C(=O)NCc3cc4c(Cl)c[nH]c4cc3F)cc2c1
Show InChI InChI=1S/C26H20ClFN4O3S/c1-36(34,35)20-2-3-24-17(9-20)6-15(12-30-24)7-19-8-16(4-5-29-19)26(33)32-13-18-10-21-22(27)14-31-25(21)11-23(18)28/h2-6,8-12,14,31H,7,13H2,1H3,(H,32,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283435
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cn2cc3cc(Cl)ccc3cc2=O)c1
Show InChI InChI=1S/C24H22ClN5O2/c1-14-7-22(26)29-15(2)21(14)11-28-24(32)17-5-6-27-20(9-17)13-30-12-18-8-19(25)4-3-16(18)10-23(30)31/h3-10,12H,11,13H2,1-2H3,(H2,26,29)(H,28,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283477
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1ccc2ccc(Cc3cc(ccn3)C(=O)NCc3c(C)cc(N)nc3C)cc2n1
Show InChI InChI=1S/C25H25N5O/c1-15-10-24(26)30-17(3)22(15)14-28-25(31)20-8-9-27-21(13-20)11-18-5-7-19-6-4-16(2)29-23(19)12-18/h4-10,12-13H,11,14H2,1-3H3,(H2,26,30)(H,28,31)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283551
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1ccc2nn(Cc3cc(ccn3)C(=O)NCc3c(C)cc(N)nc3C)cc2c1
Show InChI InChI=1S/C23H24N6O/c1-14-4-5-21-18(8-14)12-29(28-21)13-19-10-17(6-7-25-19)23(30)26-11-20-15(2)9-22(24)27-16(20)3/h4-10,12H,11,13H2,1-3H3,(H2,24,27)(H,26,30)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283436
PNG
(2-((7-chloro-3-oxoisoquinolin-2(3H)-yl)methyl)- N-...)
Show SMILES Fc1cc2[nH]cc(Cl)c2cc1CNC(=O)c1ccnc(Cn2cc3cc(Cl)ccc3cc2=O)c1
Show InChI InChI=1S/C25H17Cl2FN4O2/c26-18-2-1-14-8-24(33)32(12-17(14)5-18)13-19-6-15(3-4-29-19)25(34)31-10-16-7-20-21(27)11-30-23(20)9-22(16)28/h1-9,11-12,30H,10,13H2,(H,31,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283401
PNG
(N-((6-amino-4-methylpyridin-3-yl)methyl)-2- ((3-ch...)
Show SMILES Cc1cc(N)ncc1CNC(=O)c1ccnc(Cc2cc(C#N)c3ncc(Cl)cc3c2)c1
Show InChI InChI=1S/C24H19ClN6O/c1-14-4-22(27)29-11-19(14)12-31-24(32)16-2-3-28-21(9-16)7-15-5-17-8-20(25)13-30-23(17)18(6-15)10-26/h2-6,8-9,11,13H,7,12H2,1H3,(H2,27,29)(H,31,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283372
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cc2ccc3[nH]cc(Cl)c3c2)c1
Show InChI InChI=1S/C23H22ClN5O/c1-13-7-22(25)29-14(2)19(13)11-28-23(30)16-5-6-26-17(10-16)8-15-3-4-21-18(9-15)20(24)12-27-21/h3-7,9-10,12,27H,8,11H2,1-2H3,(H2,25,29)(H,28,30)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283361
PNG
(N-((1-aminoisoquinolin-6-yl)methyl)-2-((6- (methyl...)
Show SMILES CS(=O)(=O)c1ccc2ncc(Cc3cc(ccn3)C(=O)NCc3ccc4c(N)nccc4c3)cc2c1
Show InChI InChI=1S/C27H23N5O3S/c1-36(34,35)23-3-5-25-21(14-23)11-18(16-31-25)12-22-13-20(7-8-29-22)27(33)32-15-17-2-4-24-19(10-17)6-9-30-26(24)28/h2-11,13-14,16H,12,15H2,1H3,(H2,28,30)(H,32,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283494
PNG
(N-((1-aminoisoquinolin-6-yl)methyl)-2-((2- (aminom...)
Show SMILES NCc1ccc2cc(Cc3cc(ccn3)C(=O)NCc3ccc4c(N)nccc4c3)ccc2n1
Show InChI InChI=1S/C27H24N6O/c28-15-22-4-3-20-11-17(2-6-25(20)33-22)13-23-14-21(8-9-30-23)27(34)32-16-18-1-5-24-19(12-18)7-10-31-26(24)29/h1-12,14H,13,15-16,28H2,(H2,29,31)(H,32,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283434
PNG
(N-((6-amino-2-methylpyridin-3-yl)methyl)-2- ((7-ch...)
Show SMILES Cc1nc(N)ccc1CNC(=O)c1ccnc(Cn2cc3cc(Cl)ccc3cc2=O)c1
Show InChI InChI=1S/C23H20ClN5O2/c1-14-17(3-5-21(25)28-14)11-27-23(31)16-6-7-26-20(9-16)13-29-12-18-8-19(24)4-2-15(18)10-22(29)30/h2-10,12H,11,13H2,1H3,(H2,25,28)(H,27,31)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283370
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cn2ccc3c(Cl)cccc3c2=O)c1
Show InChI InChI=1S/C24H22ClN5O2/c1-14-10-22(26)29-15(2)20(14)12-28-23(31)16-6-8-27-17(11-16)13-30-9-7-18-19(24(30)32)4-3-5-21(18)25/h3-11H,12-13H2,1-2H3,(H2,26,29)(H,28,31)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283357
PNG
(2-((2-(acetamidomethyl)quinolin-6-yl)methyl)- N-((...)
Show SMILES CC(=O)NCc1ccc2cc(Cc3cc(ccn3)C(=O)NCc3cc4c(Cl)c[nH]c4cc3F)ccc2n1
Show InChI InChI=1S/C28H23ClFN5O2/c1-16(36)32-14-21-4-3-18-8-17(2-5-26(18)35-21)9-22-10-19(6-7-31-22)28(37)34-13-20-11-23-24(29)15-33-27(23)12-25(20)30/h2-8,10-12,15,33H,9,13-14H2,1H3,(H,32,36)(H,34,37)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283349
PNG
(6-((4-(((3-chloro-6-fluoro-1H-indol-5- yl)methyl)c...)
Show SMILES NC(=O)c1ccc2cc(Cc3cc(ccn3)C(=O)NCc3cc4c(Cl)c[nH]c4cc3F)ccc2n1
Show InChI InChI=1S/C26H19ClFN5O2/c27-20-13-31-24-11-21(28)17(10-19(20)24)12-32-26(35)16-5-6-30-18(9-16)8-14-1-3-22-15(7-14)2-4-23(33-22)25(29)34/h1-7,9-11,13,31H,8,12H2,(H2,29,34)(H,32,35)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283362
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cc2cnc3ccc(cc3c2)S(C)(=O)=O)c1
Show InChI InChI=1S/C25H25N5O3S/c1-15-8-24(26)30-16(2)22(15)14-29-25(31)18-6-7-27-20(11-18)10-17-9-19-12-21(34(3,32)33)4-5-23(19)28-13-17/h4-9,11-13H,10,14H2,1-3H3,(H2,26,30)(H,29,31)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283457
PNG
(N-((3-chloro-6-fluoro-1H-indol-5-yl)methyl)-2- ((6...)
Show SMILES Cc1ccc2nc(c(Cc3cc(ccn3)C(=O)NCc3cc4c(Cl)c[nH]c4cc3F)cc2c1)S(C)(=O)=O
Show InChI InChI=1S/C27H22ClFN4O3S/c1-15-3-4-24-17(7-15)8-18(27(33-24)37(2,35)36)10-20-9-16(5-6-30-20)26(34)32-13-19-11-21-22(28)14-31-25(21)12-23(19)29/h3-9,11-12,14,31H,10,13H2,1-2H3,(H,32,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283359
PNG
(2-((2-(acetamidomethyl)quinolin-6-yl)methyl)- N-((...)
Show SMILES CC(=O)NCc1ccc2cc(Cc3cc(ccn3)C(=O)NCc3c(C)cc(N)nc3C)ccc2n1
Show InChI InChI=1S/C27H28N6O2/c1-16-10-26(28)32-17(2)24(16)15-31-27(35)21-8-9-29-23(13-21)12-19-4-7-25-20(11-19)5-6-22(33-25)14-30-18(3)34/h4-11,13H,12,14-15H2,1-3H3,(H2,28,32)(H,30,34)(H,31,35)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283390
PNG
(2-((3-chloroquinolin-6-yl)methyl)-N-((2-methyl- 6-...)
Show SMILES CNc1ccc(CNC(=O)c2ccnc(Cc3ccc4ncc(Cl)cc4c3)c2)c(C)n1
Show InChI InChI=1S/C24H22ClN5O/c1-15-18(4-6-23(26-2)30-15)13-29-24(31)17-7-8-27-21(12-17)10-16-3-5-22-19(9-16)11-20(25)14-28-22/h3-9,11-12,14H,10,13H2,1-2H3,(H,26,30)(H,29,31)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283391
PNG
(N-((6-amino-2-cyclopropylpyridin-3-yl)methyl)- 2-(...)
Show SMILES Nc1ccc(CNC(=O)c2ccnc(Cc3ccc4ncc(Cl)cc4c3)c2)c(n1)C1CC1
Show InChI InChI=1S/C25H22ClN5O/c26-20-11-19-9-15(1-5-22(19)29-14-20)10-21-12-17(7-8-28-21)25(32)30-13-18-4-6-23(27)31-24(18)16-2-3-16/h1,4-9,11-12,14,16H,2-3,10,13H2,(H2,27,31)(H,30,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283433
PNG
(N-((6-amino-4-methylpyridin-3-yl)methyl)-2- ((7-ch...)
Show SMILES Cc1cc(N)ncc1CNC(=O)c1ccnc(Cn2cc3cc(Cl)ccc3cc2=O)c1
Show InChI InChI=1S/C23H20ClN5O2/c1-14-6-21(25)27-10-18(14)11-28-23(31)16-4-5-26-20(8-16)13-29-12-17-7-19(24)3-2-15(17)9-22(29)30/h2-10,12H,11,13H2,1H3,(H2,25,27)(H,28,31)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283482
PNG
(N-((1-aminoisoquinolin-6-yl)methyl)-2-((2- (methyl...)
Show SMILES CS(=O)(=O)c1ccc2cc(Cc3cc(ccn3)C(=O)NCc3ccc4c(N)nccc4c3)ccc2n1
Show InChI InChI=1S/C27H23N5O3S/c1-36(34,35)25-7-4-20-12-17(3-6-24(20)32-25)14-22-15-21(9-10-29-22)27(33)31-16-18-2-5-23-19(13-18)8-11-30-26(23)28/h2-13,15H,14,16H2,1H3,(H2,28,30)(H,31,33)
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n/an/a 550n/an/an/an/an/an/a



LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283483
PNG
(N-((3-chloro-6-fluoro-1H-indol-5-yl)methyl)-2- ((2...)
Show SMILES CS(=O)(=O)c1ccc2cc(Cc3cc(ccn3)C(=O)NCc3cc4c(Cl)c[nH]c4cc3F)ccc2n1
Show InChI InChI=1S/C26H20ClFN4O3S/c1-36(34,35)25-5-3-16-8-15(2-4-23(16)32-25)9-19-10-17(6-7-29-19)26(33)31-13-18-11-20-21(27)14-30-24(20)12-22(18)28/h2-8,10-12,14,30H,9,13H2,1H3,(H,31,33)
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n/an/a 550n/an/an/an/an/an/a



LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283485
PNG
(N-((3-chloro-6-fluoro-1H-indol-5-yl)methyl)-2- ((4...)
Show SMILES Fc1cc2[nH]cc(Cl)c2cc1CNC(=O)c1ccnc(Cc2ccc3nccc([N+]#[C-])c3c2)c1
Show InChI InChI=1S/C26H17ClFN5O/c1-29-23-5-7-31-24-3-2-15(9-20(23)24)8-18-10-16(4-6-30-18)26(34)33-13-17-11-19-21(27)14-32-25(19)12-22(17)28/h2-7,9-12,14,32H,8,13H2,(H,33,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283350
PNG
(6-((4-(((6-amino-2,4-dimethylpyridin-3- yl)methyl)...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cc2ccc3nc(ccc3c2)C(N)=O)c1
Show InChI InChI=1S/C25H24N6O2/c1-14-9-23(26)30-15(2)20(14)13-29-25(33)18-7-8-28-19(12-18)11-16-3-5-21-17(10-16)4-6-22(31-21)24(27)32/h3-10,12H,11,13H2,1-2H3,(H2,26,30)(H2,27,32)(H,29,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283358
PNG
(2-((2-(acetamidomethyl)quinolin-6-yl)methyl)- N-((...)
Show SMILES CC(=O)NCc1ccc2cc(Cc3cc(ccn3)C(=O)NCc3ccc4c(N)nccc4c3)ccc2n1
Show InChI InChI=1S/C29H26N6O2/c1-18(36)33-17-24-5-4-22-12-19(3-7-27(22)35-24)14-25-15-23(9-10-31-25)29(37)34-16-20-2-6-26-21(13-20)8-11-32-28(26)30/h2-13,15H,14,16-17H2,1H3,(H2,30,32)(H,33,36)(H,34,37)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283373
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1c[nH]c2ccc(Cc3cc(ccn3)C(=O)NCc3c(C)cc(N)nc3C)cc12
Show InChI InChI=1S/C24H25N5O/c1-14-8-23(25)29-16(3)21(14)13-28-24(30)18-6-7-26-19(11-18)9-17-4-5-22-20(10-17)15(2)12-27-22/h4-8,10-12,27H,9,13H2,1-3H3,(H2,25,29)(H,28,30)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283444
PNG
(6-((4-(((6-amino-2-methylpyridin-3- yl)methyl)carb...)
Show SMILES Cc1nc(N)ccc1CNC(=O)c1ccnc(Cc2cc(C(O)=O)c3ncc(Cl)cc3c2)c1
Show InChI InChI=1S/C24H20ClN5O3/c1-13-16(2-3-21(26)30-13)11-29-23(31)15-4-5-27-19(10-15)7-14-6-17-9-18(25)12-28-22(17)20(8-14)24(32)33/h2-6,8-10,12H,7,11H2,1H3,(H2,26,30)(H,29,31)(H,32,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283352
PNG
(6-((4-(((1-aminoisoquinolin-6- yl)methyl)carbamoyl...)
Show SMILES NC(=O)c1ccc2cc(Cc3cc(ccn3)C(=O)NCc3ccc4c(N)nccc4c3)ccc2n1
Show InChI InChI=1S/C27H22N6O2/c28-25-22-4-1-17(12-18(22)7-10-31-25)15-32-27(35)20-8-9-30-21(14-20)13-16-2-5-23-19(11-16)3-6-24(33-23)26(29)34/h1-12,14H,13,15H2,(H2,28,31)(H2,29,34)(H,32,35)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283356
PNG
(N-((1-aminoisoquinolin-6-yl)methyl)-2-((7- fluoroq...)
Show SMILES Nc1nccc2cc(CNC(=O)c3ccnc(Cc4cnc5ccc(F)cc5n4)c3)ccc12
Show InChI InChI=1S/C25H19FN6O/c26-18-2-4-22-23(11-18)32-20(14-30-22)12-19-10-17(6-7-28-19)25(33)31-13-15-1-3-21-16(9-15)5-8-29-24(21)27/h1-11,14H,12-13H2,(H2,27,29)(H,31,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283446
PNG
(6-amino-3-((2-((3-chloroquinolin-6- yl)methyl)ison...)
Show SMILES Cc1cc(N)[n+]([O-])c(C)c1CNC(=O)c1ccnc(Cc2ccc3ncc(Cl)cc3c2)c1
Show InChI InChI=1S/C24H22ClN5O2/c1-14-7-23(26)30(32)15(2)21(14)13-29-24(31)17-5-6-27-20(11-17)9-16-3-4-22-18(8-16)10-19(25)12-28-22/h3-8,10-12H,9,13,26H2,1-2H3,(H,29,31)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283393
PNG
(2-((2-(aminomethyl)quinolin-6-yl)methyl)-N- ((3-ch...)
Show SMILES NCc1ccc2cc(Cc3cc(ccn3)C(=O)NCc3cc4c(Cl)c[nH]c4cc3F)ccc2n1
Show InChI InChI=1S/C26H21ClFN5O/c27-22-14-31-25-11-23(28)18(10-21(22)25)13-32-26(34)17-5-6-30-20(9-17)8-15-1-4-24-16(7-15)2-3-19(12-29)33-24/h1-7,9-11,14,31H,8,12-13,29H2,(H,32,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283371
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cn2ccc3cc(Cl)ccc3c2=O)c1
Show InChI InChI=1S/C24H22ClN5O2/c1-14-9-22(26)29-15(2)21(14)12-28-23(31)17-5-7-27-19(11-17)13-30-8-6-16-10-18(25)3-4-20(16)24(30)32/h3-11H,12-13H2,1-2H3,(H2,26,29)(H,28,31)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283374
PNG
(N-((6-amino-5-cyano-2-methylpyridin-3- yl)methyl)-...)
Show SMILES Cc1nc(N)c(cc1CNC(=O)c1ccnc(Cc2ccc3ncc(Cl)cc3c2)c1)C#N
Show InChI InChI=1S/C24H19ClN6O/c1-14-19(8-18(11-26)23(27)31-14)12-30-24(32)16-4-5-28-21(10-16)7-15-2-3-22-17(6-15)9-20(25)13-29-22/h2-6,8-10,13H,7,12H2,1H3,(H2,27,31)(H,30,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283395
PNG
(N-((3-aminobenzo[d]isoxazol-6-yl)methyl)-2- ((3-me...)
Show SMILES Cc1cnc2ccc(Cc3cc(ccn3)C(=O)NCc3ccc4c(N)noc4c3)cc2c1
Show InChI InChI=1S/C25H21N5O2/c1-15-8-19-9-16(3-5-22(19)28-13-15)10-20-12-18(6-7-27-20)25(31)29-14-17-2-4-21-23(11-17)32-30-24(21)26/h2-9,11-13H,10,14H2,1H3,(H2,26,30)(H,29,31)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283376
PNG
(N-((6-amino-5-chloro-2-methylpyridin-3- yl)methyl)...)
Show SMILES Cc1nc(N)c(Cl)cc1CNC(=O)c1ccnc(Cc2ccc3ncc(Cl)cc3c2)c1
Show InChI InChI=1S/C23H19Cl2N5O/c1-13-17(10-20(25)22(26)30-13)11-29-23(31)15-4-5-27-19(9-15)7-14-2-3-21-16(6-14)8-18(24)12-28-21/h2-6,8-10,12H,7,11H2,1H3,(H2,26,30)(H,29,31)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283380
PNG
(2-((3-chloroquinolin-6-yl)methyl)-N-((6-fluoro- 1H...)
Show SMILES Fc1cc2[nH]ncc2cc1CNC(=O)c1ccnc(Cc2ccc3ncc(Cl)cc3c2)c1
Show InChI InChI=1S/C24H17ClFN5O/c25-19-8-16-5-14(1-2-22(16)28-13-19)6-20-9-15(3-4-27-20)24(32)29-11-17-7-18-12-30-31-23(18)10-21(17)26/h1-5,7-10,12-13H,6,11H2,(H,29,32)(H,30,31)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283384
PNG
(N-((3-aminobenzo[d]isoxazol-6-yl)methyl)-2- ((3-ch...)
Show SMILES Nc1noc2cc(CNC(=O)c3ccnc(Cc4ccc5ncc(Cl)cc5c4)c3)ccc12
Show InChI InChI=1S/C24H18ClN5O2/c25-18-10-17-7-14(2-4-21(17)28-13-18)8-19-11-16(5-6-27-19)24(31)29-12-15-1-3-20-22(9-15)32-30-23(20)26/h1-7,9-11,13H,8,12H2,(H2,26,30)(H,29,31)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283378
PNG
(N-((6-amino-2-(trifluoromoethyl)pyridin-3- yl)meth...)
Show SMILES Nc1ccc(CNC(=O)c2ccnc(Cc3ccc4ncc(Cl)cc4c3)c2)c(n1)C(F)(F)F
Show InChI InChI=1S/C23H17ClF3N5O/c24-17-9-16-7-13(1-3-19(16)30-12-17)8-18-10-14(5-6-29-18)22(33)31-11-15-2-4-20(28)32-21(15)23(25,26)27/h1-7,9-10,12H,8,11H2,(H2,28,32)(H,31,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283375
PNG
(2-amino-5-((2-((3-chloroquinolin-6- yl)methyl)ison...)
Show SMILES Cc1nc(N)c(cc1CNC(=O)c1ccnc(Cc2ccc3ncc(Cl)cc3c2)c1)C(N)=O
Show InChI InChI=1S/C24H21ClN6O2/c1-13-17(10-20(23(27)32)22(26)31-13)11-30-24(33)15-4-5-28-19(9-15)7-14-2-3-21-16(6-14)8-18(25)12-29-21/h2-6,8-10,12H,7,11H2,1H3,(H2,26,31)(H2,27,32)(H,30,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283396
PNG
(N-((3-aminobenzo[d]isoxazol-6-yl)methyl)-2- ((6-me...)
Show SMILES Cc1ccc2ncc(Cc3cc(ccn3)C(=O)NCc3ccc4c(N)noc4c3)cc2c1
Show InChI InChI=1S/C25H21N5O2/c1-15-2-5-22-19(8-15)9-17(14-28-22)10-20-12-18(6-7-27-20)25(31)29-13-16-3-4-21-23(11-16)32-30-24(21)26/h2-9,11-12,14H,10,13H2,1H3,(H2,26,30)(H,29,31)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM283392
PNG
(2-((3-chloroquinolin-6-yl)methyl)-N-((6- (dimethyl...)
Show SMILES CN(C)c1ccc(CNC(=O)c2ccnc(Cc3ccc4ncc(Cl)cc4c3)c2)c(C)n1
Show InChI InChI=1S/C25H24ClN5O/c1-16-19(5-7-24(30-16)31(2)3)14-29-25(32)18-8-9-27-22(13-18)11-17-4-6-23-20(10-17)12-21(26)15-28-23/h4-10,12-13,15H,11,14H2,1-3H3,(H,29,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...


US Patent US9611252 (2017)

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Ligand-Target Pair
* indicates data uncertainty>20%