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Patent code US9611267

Compile Data Set for Download or QSAR

Found 699 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM314798
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1,3,4,7-tetra...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ccc4c3NC2=O)c1F
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US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM301289
PNG
(US10131667, Example 105 | US9611267, Example 105 |...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]cc(CC#N)c4c3N(C)C2=O)c1F
Show InChI InChI=1S/C20H17F2N5O3/c1-26-17-11(8-25-19-14(17)10(4-5-23)7-24-19)9-27(20(26)28)18-15(21)12(29-2)6-13(30-3)16(18)22/h6-8H,4,9H2,1-3H3,(H,24,25)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301289
PNG
(US10131667, Example 105 | US9611267, Example 105 |...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]cc(CC#N)c4c3N(C)C2=O)c1F
Show InChI InChI=1S/C20H17F2N5O3/c1-26-17-11(8-25-19-14(17)10(4-5-23)7-24-19)9-27(20(26)28)18-15(21)12(29-2)6-13(30-3)16(18)22/h6-8H,4,9H2,1-3H3,(H,24,25)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301290
PNG
(3-(2-chloro-6-fluoro-3,5-dimethoxyphenyl)-1-cyclob...)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc4NC(=O)Cc4c3N(C3CCC3)C2=O)c1F
Show InChI InChI=1S/C21H20ClFN4O4/c1-30-13-7-14(31-2)17(23)19(16(13)22)26-9-10-8-24-20-12(6-15(28)25-20)18(10)27(21(26)29)11-4-3-5-11/h7-8,11H,3-6,9H2,1-2H3,(H,24,25,28)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM301292
PNG
(3-(2-chloro-6-fluoro-3,5-dimethoxyphenyl)-1-pyridi...)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc4[nH]ccc4c3N(C2=O)c2cccnc2)c1F
Show InChI InChI=1S/C22H17ClFN5O3/c1-31-15-8-16(32-2)18(24)20(17(15)23)28-11-12-9-27-21-14(5-7-26-21)19(12)29(22(28)30)13-4-3-6-25-10-13/h3-10H,11H2,1-2H3,(H,26,27)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301297
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-[(3,3-diflu...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CN5CCCC(F)(F)C5)cc4c3N(C)C2=O)c1F
Show InChI InChI=1S/C24H25F4N5O3/c1-31-20-13(10-33(23(31)34)21-18(25)16(35-2)8-17(36-3)19(21)26)9-29-22-15(20)7-14(30-22)11-32-6-4-5-24(27,28)12-32/h7-9H,4-6,10-12H2,1-3H3,(H,29,30)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM301297
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-[(3,3-diflu...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CN5CCCC(F)(F)C5)cc4c3N(C)C2=O)c1F
Show InChI InChI=1S/C24H25F4N5O3/c1-31-20-13(10-33(23(31)34)21-18(25)16(35-2)8-17(36-3)19(21)26)9-29-22-15(20)7-14(30-22)11-32-6-4-5-24(27,28)12-32/h7-9H,4-6,10-12H2,1-3H3,(H,29,30)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301299
PNG
(8-(2-azetidin-1-ylethyl)-3-(2,6-difluoro-3,5-dimet...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CCN5CCC5)cc4c3N(C)C2=O)c1F
Show InChI InChI=1S/C23H25F2N5O3/c1-28-20-13(11-26-22-15(20)9-14(27-22)5-8-29-6-4-7-29)12-30(23(28)31)21-18(24)16(32-2)10-17(33-3)19(21)25/h9-11H,4-8,12H2,1-3H3,(H,26,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM301301
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-methyl-8-(3...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CCCN5CCOCC5)cc4c3N(C)C2=O)c1F
Show InChI InChI=1S/C25H29F2N5O4/c1-30-22-15(14-32(25(30)33)23-20(26)18(34-2)12-19(35-3)21(23)27)13-28-24-17(22)11-16(29-24)5-4-6-31-7-9-36-10-8-31/h11-13H,4-10,14H2,1-3H3,(H,28,29)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301303
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-[(4-ethylpi...)
Show SMILES CCN1CCN(CC1)C(=O)c1cc2c3N(C)C(=O)N(Cc3cnc2[nH]1)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C25H28F2N6O4/c1-5-31-6-8-32(9-7-31)24(34)16-10-15-21-14(12-28-23(15)29-16)13-33(25(35)30(21)2)22-19(26)17(36-3)11-18(37-4)20(22)27/h10-12H,5-9,13H2,1-4H3,(H,28,29)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301305
PNG
(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4...)
Show SMILES CCN1C(=O)N(Cc2cnc3[nH]ccc3c12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C19H18F2N4O3/c1-4-24-16-10(8-23-18-11(16)5-6-22-18)9-25(19(24)26)17-14(20)12(27-2)7-13(28-3)15(17)21/h5-8H,4,9H2,1-3H3,(H,22,23)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM301305
PNG
(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4...)
Show SMILES CCN1C(=O)N(Cc2cnc3[nH]ccc3c12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C19H18F2N4O3/c1-4-24-16-10(8-23-18-11(16)5-6-22-18)9-25(19(24)26)17-14(20)12(27-2)7-13(28-3)15(17)21/h5-8H,4,9H2,1-3H3,(H,22,23)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301307
PNG
(3-{[3-(2,6-difluoro-3,5-dimethoxyphenyl)-2,8-dioxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4NC(=O)Cc4c3N(Cc3cccc(c3)C#N)C2=O)c1F
Show InChI InChI=1S/C25H19F2N5O4/c1-35-17-8-18(36-2)21(27)23(20(17)26)32-12-15-10-29-24-16(7-19(33)30-24)22(15)31(25(32)34)11-14-5-3-4-13(6-14)9-28/h3-6,8,10H,7,11-12H2,1-2H3,(H,29,30,33)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM301308
PNG
(3-(2-chloro-6-fluoro-3,5-dimethoxyphenyl)-1-(2,3-d...)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc4NC(=O)Cc4c3N(C2=O)c2cccc(F)c2F)c1F
Show InChI InChI=1S/C23H16ClF3N4O4/c1-34-14-7-15(35-2)19(27)21(17(14)24)30-9-10-8-28-22-11(6-16(32)29-22)20(10)31(23(30)33)13-5-3-4-12(25)18(13)26/h3-5,7-8H,6,9H2,1-2H3,(H,28,29,32)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301312
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-[(4...)
Show SMILES CCN1CCN(Cc2cc3c4N(CC)C(=O)N(Cc4cnc3[nH]2)c2c(F)c(OC)cc(OC)c2F)CC1
Show InChI InChI=1S/C26H32F2N6O3/c1-5-31-7-9-32(10-8-31)15-17-11-18-23-16(13-29-25(18)30-17)14-34(26(35)33(23)6-2)24-21(27)19(36-3)12-20(37-4)22(24)28/h11-13H,5-10,14-15H2,1-4H3,(H,29,30)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM301313
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-methyl-8-[(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CN5CCN(C)CC5)cc4c3N(C)C2=O)c1F
Show InChI InChI=1S/C24H28F2N6O3/c1-29-5-7-31(8-6-29)13-15-9-16-21-14(11-27-23(16)28-15)12-32(24(33)30(21)2)22-19(25)17(34-3)10-18(35-4)20(22)26/h9-11H,5-8,12-13H2,1-4H3,(H,27,28)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301314
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-{[4-(2-hydr...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CN5CCN(CCO)CC5)cc4c3N(C)C2=O)c1F
Show InChI InChI=1S/C25H30F2N6O4/c1-30-22-15(13-33(25(30)35)23-20(26)18(36-2)11-19(37-3)21(23)27)12-28-24-17(22)10-16(29-24)14-32-6-4-31(5-7-32)8-9-34/h10-12,34H,4-9,13-14H2,1-3H3,(H,28,29)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301315
PNG
(3-(4-{[3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-meth...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CN5CCN(CCC#N)CC5)cc4c3N(C)C2=O)c1F
Show InChI InChI=1S/C26H29F2N7O3/c1-32-23-16(14-35(26(32)36)24-21(27)19(37-2)12-20(38-3)22(24)28)13-30-25-18(23)11-17(31-25)15-34-9-7-33(8-10-34)6-4-5-29/h11-13H,4,6-10,14-15H2,1-3H3,(H,30,31)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301322
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-methyl-8-(1...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(Cn5cccn5)cc4c3N(C)C2=O)c1F
Show InChI InChI=1S/C22H20F2N6O3/c1-28-19-12(9-25-21-14(19)7-13(27-21)11-29-6-4-5-26-29)10-30(22(28)31)20-17(23)15(32-2)8-16(33-3)18(20)24/h4-9H,10-11H2,1-3H3,(H,25,27)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301326
PNG
(8-[2-(diethylamino)ethyl]-3-(2,6-difluoro-3,5-dime...)
Show SMILES CCN(CC)CCc1cc2c3N(C)C(=O)N(Cc3cnc2[nH]1)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C24H29F2N5O3/c1-6-30(7-2)9-8-15-10-16-21-14(12-27-23(16)28-15)13-31(24(32)29(21)3)22-19(25)17(33-4)11-18(34-5)20(22)26/h10-12H,6-9,13H2,1-5H3,(H,27,28)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301329
PNG
(3-(2-chloro-6-fluoro-3,5-dimethoxyphenyl)-1-(1-met...)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc4[nH]ncc4c3N(c3cnn(C)c3)C2=O)c1F
Show InChI InChI=1S/C20H17ClFN7O3/c1-27-9-11(6-25-27)29-17-10(5-23-19-12(17)7-24-26-19)8-28(20(29)30)18-15(21)13(31-2)4-14(32-3)16(18)22/h4-7,9H,8H2,1-3H3,(H,23,24,26)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301333
PNG
(7'-(2,6-difluoro-3,5-dimethoxyphenyl)-6',7'-dihydr...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ccc4c3C3(CCCC3)C2=O)c1F
Show InChI InChI=1S/C22H21F2N3O3/c1-29-14-9-15(30-2)18(24)19(17(14)23)27-11-12-10-26-20-13(5-8-25-20)16(12)22(21(27)28)6-3-4-7-22/h5,8-10H,3-4,6-7,11H2,1-2H3,(H,25,26)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301334
PNG
(7'-(2,6-difluoro-3,5-dimethoxyphenyl)-2,3,5,6,6',7...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ccc4c3C3(CCOCC3)C2=O)c1F
Show InChI InChI=1S/C22H21F2N3O4/c1-29-14-9-15(30-2)18(24)19(17(14)23)27-11-12-10-26-20-13(3-6-25-20)16(12)22(21(27)28)4-7-31-8-5-22/h3,6,9-10H,4-5,7-8,11H2,1-2H3,(H,25,26)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM301334
PNG
(7'-(2,6-difluoro-3,5-dimethoxyphenyl)-2,3,5,6,6',7...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ccc4c3C3(CCOCC3)C2=O)c1F
Show InChI InChI=1S/C22H21F2N3O4/c1-29-14-9-15(30-2)18(24)19(17(14)23)27-11-12-10-26-20-13(3-6-25-20)16(12)22(21(27)28)4-7-31-8-5-22/h3,6,9-10H,4-5,7-8,11H2,1-2H3,(H,25,26)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301349
PNG
(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-[2-(1H-pyra...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ncc4c3N(CCn3cccn3)C2=O)c1F
Show InChI InChI=1S/C21H19F2N7O3/c1-32-14-8-15(33-2)17(23)19(16(14)22)30-11-12-9-24-20-13(10-25-27-20)18(12)29(21(30)31)7-6-28-5-3-4-26-28/h3-5,8-10H,6-7,11H2,1-2H3,(H,24,25,27)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301350
PNG
(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-[(2R)-tetra...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ncc4c3N(C[C@H]3CCCO3)C2=O)c1F
Show InChI InChI=1S/C21H21F2N5O4/c1-30-14-6-15(31-2)17(23)19(16(14)22)27-9-11-7-24-20-13(8-25-26-20)18(11)28(21(27)29)10-12-4-3-5-32-12/h6-8,12H,3-5,9-10H2,1-2H3,(H,24,25,26)/t12-/m1/s1
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM301351
PNG
(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-[(2S)-tetra...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ncc4c3N(C[C@@H]3CCCO3)C2=O)c1F
Show InChI InChI=1S/C21H21F2N5O4/c1-30-14-6-15(31-2)17(23)19(16(14)22)27-9-11-7-24-20-13(8-25-26-20)18(11)28(21(27)29)10-12-4-3-5-32-12/h6-8,12H,3-5,9-10H2,1-2H3,(H,24,25,26)/t12-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301355
PNG
(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-(2-pyridin-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ncc4c3N(CCc3ccncc3)C2=O)c1F
Show InChI InChI=1S/C23H20F2N6O3/c1-33-16-9-17(34-2)19(25)21(18(16)24)31-12-14-10-27-22-15(11-28-29-22)20(14)30(23(31)32)8-5-13-3-6-26-7-4-13/h3-4,6-7,9-11H,5,8,12H2,1-2H3,(H,27,28,29)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301361
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-[(2-methoxy...)
Show SMILES COc1cc(CN2C(=O)N(Cc3cnc4[nH]ncc4c23)c2c(F)c(OC)cc(OC)c2F)ccn1
Show InChI InChI=1S/C23H20F2N6O4/c1-33-15-7-16(34-2)19(25)21(18(15)24)31-11-13-8-27-22-14(9-28-29-22)20(13)30(23(31)32)10-12-4-5-26-17(6-12)35-3/h4-9H,10-11H2,1-3H3,(H,27,28,29)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301363
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-[(3S)-tetra...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ncc4c3N(C[C@@H]3CCOC3)C2=O)c1F
Show InChI InChI=1S/C21H21F2N5O4/c1-30-14-5-15(31-2)17(23)19(16(14)22)28-9-12-6-24-20-13(7-25-26-20)18(12)27(21(28)29)8-11-3-4-32-10-11/h5-7,11H,3-4,8-10H2,1-2H3,(H,24,25,26)/t11-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301366
PNG
(1-cyclobutyl-3-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CN5CCOCC5)cc4c3N(C3CCC3)C2=O)c1F
Show InChI InChI=1S/C26H29F2N5O4/c1-35-19-11-20(36-2)22(28)24(21(19)27)32-13-15-12-29-25-18(23(15)33(26(32)34)17-4-3-5-17)10-16(30-25)14-31-6-8-37-9-7-31/h10-12,17H,3-9,13-14H2,1-2H3,(H,29,30)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM301366
PNG
(1-cyclobutyl-3-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CN5CCOCC5)cc4c3N(C3CCC3)C2=O)c1F
Show InChI InChI=1S/C26H29F2N5O4/c1-35-19-11-20(36-2)22(28)24(21(19)27)32-13-15-12-29-25-18(23(15)33(26(32)34)17-4-3-5-17)10-16(30-25)14-31-6-8-37-9-7-31/h10-12,17H,3-9,13-14H2,1-2H3,(H,29,30)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301374
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(4-fluoroph...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CN5CCN(C)CC5)cc4c3N(C2=O)c2ccc(F)cc2)c1F
Show InChI InChI=1S/C29H29F3N6O3/c1-35-8-10-36(11-9-35)16-19-12-21-26-17(14-33-28(21)34-19)15-37(29(39)38(26)20-6-4-18(30)5-7-20)27-24(31)22(40-2)13-23(41-3)25(27)32/h4-7,12-14H,8-11,15-16H2,1-3H3,(H,33,34)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM301375
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(4-fluoroph...)
Show SMILES CCN1CCN(Cc2cc3c4N(C(=O)N(Cc4cnc3[nH]2)c2c(F)c(OC)cc(OC)c2F)c2ccc(F)cc2)CC1
Show InChI InChI=1S/C30H31F3N6O3/c1-4-36-9-11-37(12-10-36)17-20-13-22-27-18(15-34-29(22)35-20)16-38(30(40)39(27)21-7-5-19(31)6-8-21)28-25(32)23(41-2)14-24(42-3)26(28)33/h5-8,13-15H,4,9-12,16-17H2,1-3H3,(H,34,35)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301378
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(morpholin-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CN5CCOCC5)cc4c3N(C2=O)c2ccncc2)c1F
Show InChI InChI=1S/C27H26F2N6O4/c1-37-20-12-21(38-2)23(29)25(22(20)28)34-14-16-13-31-26-19(11-17(32-26)15-33-7-9-39-10-8-33)24(16)35(27(34)36)18-3-5-30-6-4-18/h3-6,11-13H,7-10,14-15H2,1-2H3,(H,31,32)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301381
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-fluoroph...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CCN5CCN(C)CC5)cc4c3N(C2=O)c2ccccc2F)c1F
Show InChI InChI=1S/C30H31F3N6O3/c1-36-10-12-37(13-11-36)9-8-19-14-20-27-18(16-34-29(20)35-19)17-38(30(40)39(27)22-7-5-4-6-21(22)31)28-25(32)23(41-2)15-24(42-3)26(28)33/h4-7,14-16H,8-13,17H2,1-3H3,(H,34,35)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM301384
PNG
(N-cyclopropyl-3-[3-(2,6-difluoro-3,5-dimethoxyphen...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ncc4c3N(C2=O)c2cccc(C(=O)NC3CC3)c2F)c1F
Show InChI InChI=1S/C26H21F3N6O4/c1-38-17-8-18(39-2)21(29)23(20(17)28)34-11-12-9-30-24-15(10-31-33-24)22(12)35(26(34)37)16-5-3-4-14(19(16)27)25(36)32-13-6-7-13/h3-5,8-10,13H,6-7,11H2,1-2H3,(H,32,36)(H,30,31,33)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM301385
PNG
(3-[3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-2,3,...)
Show SMILES CCNC(=O)c1cccc(N2C(=O)N(Cc3cnc4[nH]ncc4c23)c2c(F)c(OC)cc(OC)c2F)c1F
Show InChI InChI=1S/C25H21F3N6O4/c1-4-29-24(35)13-6-5-7-15(18(13)26)34-21-12(9-30-23-14(21)10-31-32-23)11-33(25(34)36)22-19(27)16(37-2)8-17(38-3)20(22)28/h5-10H,4,11H2,1-3H3,(H,29,35)(H,30,31,32)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM301393
PNG
((3R)-1-{[3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-me...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CN5CC[C@H](C5)C#N)cc4c3N(C)C2=O)c1F
Show InChI InChI=1S/C24H24F2N6O3/c1-30-21-14(9-28-23-16(21)6-15(29-23)12-31-5-4-13(8-27)10-31)11-32(24(30)33)22-19(25)17(34-2)7-18(35-3)20(22)26/h6-7,9,13H,4-5,10-12H2,1-3H3,(H,28,29)/t13-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301395
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2,3-difluo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CN5CCOCC5)cc4c3N(C2=O)c2cccc(F)c2F)c1F
Show InChI InChI=1S/C28H25F4N5O4/c1-39-20-11-21(40-2)24(32)26(23(20)31)36-13-15-12-33-27-17(10-16(34-27)14-35-6-8-41-9-7-35)25(15)37(28(36)38)19-5-3-4-18(29)22(19)30/h3-5,10-12H,6-9,13-14H2,1-2H3,(H,33,34)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM301398
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(3-fluoroph...)
Show SMILES CCN1CCN(Cc2cc3c4N(C(=O)N(Cc4cnc3[nH]2)c2c(F)c(OC)cc(OC)c2F)c2cccc(F)c2)CC1
Show InChI InChI=1S/C30H31F3N6O3/c1-4-36-8-10-37(11-9-36)17-20-13-22-27-18(15-34-29(22)35-20)16-38(30(40)39(27)21-7-5-6-19(31)12-21)28-25(32)23(41-2)14-24(42-3)26(28)33/h5-7,12-15H,4,8-11,16-17H2,1-3H3,(H,34,35)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM301402
PNG
(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-(3-fluoropy...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ncc4c3N(C2=O)c2ncccc2F)c1F
Show InChI InChI=1S/C21H15F3N6O3/c1-32-13-6-14(33-2)16(24)18(15(13)23)29-9-10-7-26-19-11(8-27-28-19)17(10)30(21(29)31)20-12(22)4-3-5-25-20/h3-8H,9H2,1-2H3,(H,26,27,28)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301407
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2,3-difluo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CCN5CCN(C)CC5)cc4c3N(C2=O)c2cccc(F)c2F)c1F
Show InChI InChI=1S/C30H30F4N6O3/c1-37-9-11-38(12-10-37)8-7-18-13-19-27-17(15-35-29(19)36-18)16-39(28-25(33)22(42-2)14-23(43-3)26(28)34)30(41)40(27)21-6-4-5-20(31)24(21)32/h4-6,13-15H,7-12,16H2,1-3H3,(H,35,36)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301407
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2,3-difluo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CCN5CCN(C)CC5)cc4c3N(C2=O)c2cccc(F)c2F)c1F
Show InChI InChI=1S/C30H30F4N6O3/c1-37-9-11-38(12-10-37)8-7-18-13-19-27-17(15-35-29(19)36-18)16-39(28-25(33)22(42-2)14-23(43-3)26(28)34)30(41)40(27)21-6-4-5-20(31)24(21)32/h4-6,13-15H,7-12,16H2,1-3H3,(H,35,36)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301187
PNG
(3-(3,5-Dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro...)
Show SMILES CCN1C(=O)N(Cc2cnc3[nH]ccc3c12)c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C19H20N4O3/c1-4-22-17-12(10-21-18-16(17)5-6-20-18)11-23(19(22)24)13-7-14(25-2)9-15(8-13)26-3/h5-10H,4,11H2,1-3H3,(H,20,21)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM301188
PNG
(1-Cyclopropyl-3-(3,5-dimethoxyphenyl)-1,3,4,7-tetr...)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc3[nH]ccc3c2N(C2CC2)C1=O
Show InChI InChI=1S/C20H20N4O3/c1-26-15-7-14(8-16(9-15)27-2)23-11-12-10-22-19-17(5-6-21-19)18(12)24(20(23)25)13-3-4-13/h5-10,13H,3-4,11H2,1-2H3,(H,21,22)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM301189
PNG
(1-(Cyclopropylmethyl)-3-(3,5-dimethoxyphenyl)-1,3,...)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc3[nH]ccc3c2N(CC2CC2)C1=O
Show InChI InChI=1S/C21H22N4O3/c1-27-16-7-15(8-17(9-16)28-2)24-12-14-10-23-20-18(5-6-22-20)19(14)25(21(24)26)11-13-3-4-13/h5-10,13H,3-4,11-12H2,1-2H3,(H,22,23)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM301191
PNG
(3-(2-Chloro-3,5-dimethoxyphenyl)-1-methyl-1,3,4,7-...)
Show SMILES COc1cc(OC)c(Cl)c(c1)N1Cc2cnc3[nH]ccc3c2N(C)C1=O
Show InChI InChI=1S/C18H17ClN4O3/c1-22-16-10(8-21-17-12(16)4-5-20-17)9-23(18(22)24)13-6-11(25-2)7-14(26-3)15(13)19/h4-8H,9H2,1-3H3,(H,20,21)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301195
PNG
(3-(3,5-Dimethoxyphenyl)-1-methyl-8-(1-methyl-1H-py...)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc3[nH]c(cc3c2N(C)C1=O)-c1cnn(C)c1
Show InChI InChI=1S/C22H22N6O3/c1-26-11-13(10-24-26)19-8-18-20-14(9-23-21(18)25-19)12-28(22(29)27(20)2)15-5-16(30-3)7-17(6-15)31-4/h5-11H,12H2,1-4H3,(H,23,25)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301200
PNG
(3-(2-Chloro-3,5-dimethoxyphenyl)-1-methyl-2-oxo-2,...)
Show SMILES COc1cc(OC)c(Cl)c(c1)N1Cc2cnc3[nH]c(cc3c2N(C)C1=O)C#N
Show InChI InChI=1S/C19H16ClN5O3/c1-24-17-10(8-22-18-13(17)4-11(7-21)23-18)9-25(19(24)26)14-5-12(27-2)6-15(28-3)16(14)20/h4-6,8H,9H2,1-3H3,(H,22,23)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)

More data for this
Ligand-Target Pair
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