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Patent code US9616063

Compile Data Set for Download or QSAR
Found 30 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Myeloperoxidase


(Homo sapiens (Human))
BDBM312171
PNG
(1-[2-(1-Aminoethyl)-4-chlorobenzyl]-2-thioxo-1,2,3...)
Show SMILES CC(N)c1cc(Cl)ccc1Cn1c2cc[nH]c2c(=O)[nH]c1=S
Show InChI InChI=1S/C15H15ClN4OS/c1-8(17)11-6-10(16)3-2-9(11)7-20-12-4-5-18-13(12)14(21)19-15(20)22/h2-6,8,18H,7,17H2,1H3,(H,19,21,22)
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US Patent
n/an/a 7n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...


US Patent US9616063 (2017)

More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM312172
PNG
(Alternative Preparation | US9616063, 3)
Show SMILES C[C@@H](N)c1cc(Cl)ccc1Cn1c2cc[nH]c2c(=O)[nH]c1=S
Show InChI InChI=1S/C15H15ClN4OS/c1-8(17)11-6-10(16)3-2-9(11)7-20-12-4-5-18-13(12)14(21)19-15(20)22/h2-6,8,18H,7,17H2,1H3,(H,19,21,22)/t8-/m1/s1
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n/an/a 7n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...


US Patent US9616063 (2017)

More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM312157
PNG
(1-{2-[(1R)-1-Aminopropyl]-4-chlorobenzyl}-2-thioxo...)
Show SMILES CC[C@@H](N)c1cc(Cl)ccc1Cn1c2cc[nH]c2c(=O)[nH]c1=S
Show InChI InChI=1S/C16H17ClN4OS/c1-2-12(18)11-7-10(17)4-3-9(11)8-21-13-5-6-19-14(13)15(22)20-16(21)23/h3-7,12,19H,2,8,18H2,1H3,(H,20,22,23)/t12-/m1/s1
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n/an/a 8.60n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...


US Patent US9616063 (2017)

More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM312256
PNG
(1-{2-[(Cyclobutylamino)methyl]benzyl}-2-thioxo-1,2...)
Show SMILES O=c1[nH]c(=S)n(Cc2ccccc2CNC2CCC2)c2cc[nH]c12
Show InChI InChI=1S/C18H20N4OS/c23-17-16-15(8-9-19-16)22(18(24)21-17)11-13-5-2-1-4-12(13)10-20-14-6-3-7-14/h1-2,4-5,8-9,14,19-20H,3,6-7,10-11H2,(H,21,23,24)
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n/an/a 10n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...


US Patent US9616063 (2017)

More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM312245
PNG
(1-{4-Chloro-2-[(methylamino)methyl]benzyl}-2-thiox...)
Show SMILES CNCc1cc(Cl)ccc1Cn1c2cc[nH]c2c(=O)[nH]c1=S
Show InChI InChI=1S/C15H15ClN4OS/c1-17-7-10-6-11(16)3-2-9(10)8-20-12-4-5-18-13(12)14(21)19-15(20)22/h2-6,17-18H,7-8H2,1H3,(H,19,21,22)
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n/an/a 13n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...


US Patent US9616063 (2017)

More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM312257
PNG
(1-{2-[(Cyclopentylamino)methyl]benzyl}-2-thioxo-1,...)
Show SMILES O=c1[nH]c(=S)n(Cc2ccccc2CNC2CCCC2)c2cc[nH]c12
Show InChI InChI=1S/C19H22N4OS/c24-18-17-16(9-10-20-17)23(19(25)22-18)12-14-6-2-1-5-13(14)11-21-15-7-3-4-8-15/h1-2,5-6,9-10,15,20-21H,3-4,7-8,11-12H2,(H,22,24,25)
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n/an/a 14n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...


US Patent US9616063 (2017)

More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM312244
PNG
(1-[2-(Aminomethyl)-4-chlorobenzyl]-2-thioxo-1,2,3,...)
Show SMILES NCc1cc(Cl)ccc1Cn1c2cc[nH]c2c(=O)[nH]c1=S
Show InChI InChI=1S/C14H13ClN4OS/c15-10-2-1-8(9(5-10)6-16)7-19-11-3-4-17-12(11)13(20)18-14(19)21/h1-5,17H,6-7,16H2,(H,18,20,21)
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n/an/a 15n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...


US Patent US9616063 (2017)

More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM312176
PNG
(1-{4-Chloro-2-[1-(methylamino)ethyl]benzyl}-2-thio...)
Show SMILES CNC(C)c1cc(Cl)ccc1Cn1c2cc[nH]c2c(=O)[nH]c1=S
Show InChI InChI=1S/C16H17ClN4OS/c1-9(18-2)12-7-11(17)4-3-10(12)8-21-13-5-6-19-14(13)15(22)20-16(21)23/h3-7,9,18-19H,8H2,1-2H3,(H,20,22,23)
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n/an/a 19n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...


US Patent US9616063 (2017)

More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM312243
PNG
(1-{4-Chloro-2-[(ethylamino)methyl]benzyl}-2-thioxo...)
Show SMILES CCNCc1cc(Cl)ccc1Cn1c2cc[nH]c2c(=O)[nH]c1=S
Show InChI InChI=1S/C16H17ClN4OS/c1-2-18-8-11-7-12(17)4-3-10(11)9-21-13-5-6-19-14(13)15(22)20-16(21)23/h3-7,18-19H,2,8-9H2,1H3,(H,20,22,23)
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AstraZeneca AB

US Patent


Assay Description
The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...


US Patent US9616063 (2017)

More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM312261
PNG
(1-{2-[(Propan-2-ylamino)methyl]benzyl}-2-thioxo-1,...)
Show SMILES CC(C)NCc1ccccc1Cn1c2cc[nH]c2c(=O)[nH]c1=S
Show InChI InChI=1S/C17H20N4OS/c1-11(2)19-9-12-5-3-4-6-13(12)10-21-14-7-8-18-15(14)16(22)20-17(21)23/h3-8,11,18-19H,9-10H2,1-2H3,(H,20,22,23)
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n/an/a 24n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...


US Patent US9616063 (2017)

More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM312251
PNG
(1-(2-{[(Cyclobutylmethyl)amino]methyl}benzyl)-2-th...)
Show SMILES O=c1[nH]c(=S)n(Cc2ccccc2CNCC2CCC2)c2cc[nH]c12
Show InChI InChI=1S/C19H22N4OS/c24-18-17-16(8-9-21-17)23(19(25)22-18)12-15-7-2-1-6-14(15)11-20-10-13-4-3-5-13/h1-2,6-9,13,20-21H,3-5,10-12H2,(H,22,24,25)
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n/an/a 29n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...


US Patent US9616063 (2017)

More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM312264
PNG
(1-[2-(Aminomethyl)-4-(trifluoromethyl)benzyl]-2-th...)
Show SMILES NCc1cc(ccc1Cn1c2cc[nH]c2c(=O)[nH]c1=S)C(F)(F)F
Show InChI InChI=1S/C15H13F3N4OS/c16-15(17,18)10-2-1-8(9(5-10)6-19)7-22-11-3-4-20-12(11)13(23)21-14(22)24/h1-5,20H,6-7,19H2,(H,21,23,24)
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n/an/a 40n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...


US Patent US9616063 (2017)

More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM312173
PNG
(1-{2-[(1S)-1-Aminoethyl]-4-chlorobenzyl}-2-thioxo-...)
Show SMILES C[C@H](N)c1cc(Cl)ccc1Cn1c2cc[nH]c2c(=O)[nH]c1=S
Show InChI InChI=1S/C15H15ClN4OS/c1-8(17)11-6-10(16)3-2-9(11)7-20-12-4-5-18-13(12)14(21)19-15(20)22/h2-6,8,18H,7,17H2,1H3,(H,19,21,22)/t8-/m0/s1
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n/an/a 42n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...


US Patent US9616063 (2017)

More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM312265
PNG
(1-{2-[(Methylamino)methyl]-4-(trifluoromethyl)benz...)
Show SMILES CNCc1cc(ccc1Cn1c2cc[nH]c2c(=O)[nH]c1=S)C(F)(F)F
Show InChI InChI=1S/C16H15F3N4OS/c1-20-7-10-6-11(16(17,18)19)3-2-9(10)8-23-12-4-5-21-13(12)14(24)22-15(23)25/h2-6,20-21H,7-8H2,1H3,(H,22,24,25)
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AstraZeneca AB

US Patent


Assay Description
The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...


US Patent US9616063 (2017)

More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM312258
PNG
(1-(2-{[(2-Methylpropyl)amino]methyl}benzyl)-2-thio...)
Show SMILES CC(C)CNCc1ccccc1Cn1c2cc[nH]c2c(=O)[nH]c1=S
Show InChI InChI=1S/C18H22N4OS/c1-12(2)9-19-10-13-5-3-4-6-14(13)11-22-15-7-8-20-16(15)17(23)21-18(22)24/h3-8,12,19-20H,9-11H2,1-2H3,(H,21,23,24)
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n/an/a 54n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...


US Patent US9616063 (2017)

More data for this
Ligand-Target Pair
Thyroid peroxidase (TPO)


(Homo sapiens (Human))
BDBM312172
PNG
(Alternative Preparation | US9616063, 3)
Show SMILES C[C@@H](N)c1cc(Cl)ccc1Cn1c2cc[nH]c2c(=O)[nH]c1=S
Show InChI InChI=1S/C15H15ClN4OS/c1-8(17)11-6-10(16)3-2-9(11)7-20-12-4-5-18-13(12)14(21)19-15(20)22/h2-6,8,18H,7,17H2,1H3,(H,19,21,22)/t8-/m1/s1
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n/an/a 4.30E+3n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
To detect thyroid peroxidase (TPO) inhibitory activity, the production of hypoiodous acid (HOI) was quantified. HOI was detected by reacting it with ...


US Patent US9616063 (2017)

More data for this
Ligand-Target Pair
Thyroid peroxidase (TPO)


(Homo sapiens (Human))
BDBM312157
PNG
(1-{2-[(1R)-1-Aminopropyl]-4-chlorobenzyl}-2-thioxo...)
Show SMILES CC[C@@H](N)c1cc(Cl)ccc1Cn1c2cc[nH]c2c(=O)[nH]c1=S
Show InChI InChI=1S/C16H17ClN4OS/c1-2-12(18)11-7-10(17)4-3-9(11)8-21-13-5-6-19-14(13)15(22)20-16(21)23/h3-7,12,19H,2,8,18H2,1H3,(H,20,22,23)/t12-/m1/s1
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n/an/a 4.40E+3n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
To detect thyroid peroxidase (TPO) inhibitory activity, the production of hypoiodous acid (HOI) was quantified. HOI was detected by reacting it with ...


US Patent US9616063 (2017)

More data for this
Ligand-Target Pair
Thyroid peroxidase (TPO)


(Homo sapiens (Human))
BDBM312171
PNG
(1-[2-(1-Aminoethyl)-4-chlorobenzyl]-2-thioxo-1,2,3...)
Show SMILES CC(N)c1cc(Cl)ccc1Cn1c2cc[nH]c2c(=O)[nH]c1=S
Show InChI InChI=1S/C15H15ClN4OS/c1-8(17)11-6-10(16)3-2-9(11)7-20-12-4-5-18-13(12)14(21)19-15(20)22/h2-6,8,18H,7,17H2,1H3,(H,19,21,22)
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n/an/a 8.80E+3n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
To detect thyroid peroxidase (TPO) inhibitory activity, the production of hypoiodous acid (HOI) was quantified. HOI was detected by reacting it with ...


US Patent US9616063 (2017)

More data for this
Ligand-Target Pair
Thyroid peroxidase (TPO)


(Homo sapiens (Human))
BDBM312176
PNG
(1-{4-Chloro-2-[1-(methylamino)ethyl]benzyl}-2-thio...)
Show SMILES CNC(C)c1cc(Cl)ccc1Cn1c2cc[nH]c2c(=O)[nH]c1=S
Show InChI InChI=1S/C16H17ClN4OS/c1-9(18-2)12-7-11(17)4-3-10(12)8-21-13-5-6-19-14(13)15(22)20-16(21)23/h3-7,9,18-19H,8H2,1-2H3,(H,20,22,23)
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n/an/a 8.90E+3n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
To detect thyroid peroxidase (TPO) inhibitory activity, the production of hypoiodous acid (HOI) was quantified. HOI was detected by reacting it with ...


US Patent US9616063 (2017)

More data for this
Ligand-Target Pair
Thyroid peroxidase (TPO)


(Homo sapiens (Human))
BDBM312243
PNG
(1-{4-Chloro-2-[(ethylamino)methyl]benzyl}-2-thioxo...)
Show SMILES CCNCc1cc(Cl)ccc1Cn1c2cc[nH]c2c(=O)[nH]c1=S
Show InChI InChI=1S/C16H17ClN4OS/c1-2-18-8-11-7-12(17)4-3-10(11)9-21-13-5-6-19-14(13)15(22)20-16(21)23/h3-7,18-19H,2,8-9H2,1H3,(H,20,22,23)
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n/an/a 1.00E+4n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
To detect thyroid peroxidase (TPO) inhibitory activity, the production of hypoiodous acid (HOI) was quantified. HOI was detected by reacting it with ...


US Patent US9616063 (2017)

More data for this
Ligand-Target Pair
Thyroid peroxidase (TPO)


(Homo sapiens (Human))
BDBM312256
PNG
(1-{2-[(Cyclobutylamino)methyl]benzyl}-2-thioxo-1,2...)
Show SMILES O=c1[nH]c(=S)n(Cc2ccccc2CNC2CCC2)c2cc[nH]c12
Show InChI InChI=1S/C18H20N4OS/c23-17-16-15(8-9-19-16)22(18(24)21-17)11-13-5-2-1-4-12(13)10-20-14-6-3-7-14/h1-2,4-5,8-9,14,19-20H,3,6-7,10-11H2,(H,21,23,24)
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US Patent
n/an/a 1.10E+4n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
To detect thyroid peroxidase (TPO) inhibitory activity, the production of hypoiodous acid (HOI) was quantified. HOI was detected by reacting it with ...


US Patent US9616063 (2017)

More data for this
Ligand-Target Pair
Thyroid peroxidase (TPO)


(Homo sapiens (Human))
BDBM312244
PNG
(1-[2-(Aminomethyl)-4-chlorobenzyl]-2-thioxo-1,2,3,...)
Show SMILES NCc1cc(Cl)ccc1Cn1c2cc[nH]c2c(=O)[nH]c1=S
Show InChI InChI=1S/C14H13ClN4OS/c15-10-2-1-8(9(5-10)6-16)7-19-11-3-4-17-12(11)13(20)18-14(19)21/h1-5,17H,6-7,16H2,(H,18,20,21)
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UniChem
US Patent
n/an/a 1.10E+4n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
To detect thyroid peroxidase (TPO) inhibitory activity, the production of hypoiodous acid (HOI) was quantified. HOI was detected by reacting it with ...


US Patent US9616063 (2017)

More data for this
Ligand-Target Pair
Thyroid peroxidase (TPO)


(Homo sapiens (Human))
BDBM312265
PNG
(1-{2-[(Methylamino)methyl]-4-(trifluoromethyl)benz...)
Show SMILES CNCc1cc(ccc1Cn1c2cc[nH]c2c(=O)[nH]c1=S)C(F)(F)F
Show InChI InChI=1S/C16H15F3N4OS/c1-20-7-10-6-11(16(17,18)19)3-2-9(10)8-23-12-4-5-21-13(12)14(24)22-15(23)25/h2-6,20-21H,7-8H2,1H3,(H,22,24,25)
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n/an/a 1.10E+4n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
To detect thyroid peroxidase (TPO) inhibitory activity, the production of hypoiodous acid (HOI) was quantified. HOI was detected by reacting it with ...


US Patent US9616063 (2017)

More data for this
Ligand-Target Pair
Thyroid peroxidase (TPO)


(Homo sapiens (Human))
BDBM312245
PNG
(1-{4-Chloro-2-[(methylamino)methyl]benzyl}-2-thiox...)
Show SMILES CNCc1cc(Cl)ccc1Cn1c2cc[nH]c2c(=O)[nH]c1=S
Show InChI InChI=1S/C15H15ClN4OS/c1-17-7-10-6-11(16)3-2-9(10)8-20-12-4-5-18-13(12)14(21)19-15(20)22/h2-6,17-18H,7-8H2,1H3,(H,19,21,22)
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AstraZeneca AB

US Patent


Assay Description
To detect thyroid peroxidase (TPO) inhibitory activity, the production of hypoiodous acid (HOI) was quantified. HOI was detected by reacting it with ...


US Patent US9616063 (2017)

More data for this
Ligand-Target Pair
Thyroid peroxidase (TPO)


(Homo sapiens (Human))
BDBM312251
PNG
(1-(2-{[(Cyclobutylmethyl)amino]methyl}benzyl)-2-th...)
Show SMILES O=c1[nH]c(=S)n(Cc2ccccc2CNCC2CCC2)c2cc[nH]c12
Show InChI InChI=1S/C19H22N4OS/c24-18-17-16(8-9-21-17)23(19(25)22-18)12-15-7-2-1-6-14(15)11-20-10-13-4-3-5-13/h1-2,6-9,13,20-21H,3-5,10-12H2,(H,22,24,25)
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AstraZeneca AB

US Patent


Assay Description
To detect thyroid peroxidase (TPO) inhibitory activity, the production of hypoiodous acid (HOI) was quantified. HOI was detected by reacting it with ...


US Patent US9616063 (2017)

More data for this
Ligand-Target Pair
Thyroid peroxidase (TPO)


(Homo sapiens (Human))
BDBM312257
PNG
(1-{2-[(Cyclopentylamino)methyl]benzyl}-2-thioxo-1,...)
Show SMILES O=c1[nH]c(=S)n(Cc2ccccc2CNC2CCCC2)c2cc[nH]c12
Show InChI InChI=1S/C19H22N4OS/c24-18-17-16(9-10-20-17)23(19(25)22-18)12-14-6-2-1-5-13(14)11-21-15-7-3-4-8-15/h1-2,5-6,9-10,15,20-21H,3-4,7-8,11-12H2,(H,22,24,25)
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n/an/a 1.90E+4n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
To detect thyroid peroxidase (TPO) inhibitory activity, the production of hypoiodous acid (HOI) was quantified. HOI was detected by reacting it with ...


US Patent US9616063 (2017)

More data for this
Ligand-Target Pair
Thyroid peroxidase (TPO)


(Homo sapiens (Human))
BDBM312264
PNG
(1-[2-(Aminomethyl)-4-(trifluoromethyl)benzyl]-2-th...)
Show SMILES NCc1cc(ccc1Cn1c2cc[nH]c2c(=O)[nH]c1=S)C(F)(F)F
Show InChI InChI=1S/C15H13F3N4OS/c16-15(17,18)10-2-1-8(9(5-10)6-19)7-22-11-3-4-20-12(11)13(23)21-14(22)24/h1-5,20H,6-7,19H2,(H,21,23,24)
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AstraZeneca AB

US Patent


Assay Description
To detect thyroid peroxidase (TPO) inhibitory activity, the production of hypoiodous acid (HOI) was quantified. HOI was detected by reacting it with ...


US Patent US9616063 (2017)

More data for this
Ligand-Target Pair
Thyroid peroxidase (TPO)


(Homo sapiens (Human))
BDBM312261
PNG
(1-{2-[(Propan-2-ylamino)methyl]benzyl}-2-thioxo-1,...)
Show SMILES CC(C)NCc1ccccc1Cn1c2cc[nH]c2c(=O)[nH]c1=S
Show InChI InChI=1S/C17H20N4OS/c1-11(2)19-9-12-5-3-4-6-13(12)10-21-14-7-8-18-15(14)16(22)20-17(21)23/h3-8,11,18-19H,9-10H2,1-2H3,(H,20,22,23)
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AstraZeneca AB

US Patent


Assay Description
To detect thyroid peroxidase (TPO) inhibitory activity, the production of hypoiodous acid (HOI) was quantified. HOI was detected by reacting it with ...


US Patent US9616063 (2017)

More data for this
Ligand-Target Pair
Thyroid peroxidase (TPO)


(Homo sapiens (Human))
BDBM312258
PNG
(1-(2-{[(2-Methylpropyl)amino]methyl}benzyl)-2-thio...)
Show SMILES CC(C)CNCc1ccccc1Cn1c2cc[nH]c2c(=O)[nH]c1=S
Show InChI InChI=1S/C18H22N4OS/c1-12(2)9-19-10-13-5-3-4-6-14(13)11-22-15-7-8-20-16(15)17(23)21-18(22)24/h3-8,12,19-20H,9-11H2,1-2H3,(H,21,23,24)
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AstraZeneca AB

US Patent


Assay Description
To detect thyroid peroxidase (TPO) inhibitory activity, the production of hypoiodous acid (HOI) was quantified. HOI was detected by reacting it with ...


US Patent US9616063 (2017)

More data for this
Ligand-Target Pair
Thyroid peroxidase (TPO)


(Homo sapiens (Human))
BDBM312173
PNG
(1-{2-[(1S)-1-Aminoethyl]-4-chlorobenzyl}-2-thioxo-...)
Show SMILES C[C@H](N)c1cc(Cl)ccc1Cn1c2cc[nH]c2c(=O)[nH]c1=S
Show InChI InChI=1S/C15H15ClN4OS/c1-8(17)11-6-10(16)3-2-9(11)7-20-12-4-5-18-13(12)14(21)19-15(20)22/h2-6,8,18H,7,17H2,1H3,(H,19,21,22)/t8-/m0/s1
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AstraZeneca AB

US Patent


Assay Description
To detect thyroid peroxidase (TPO) inhibitory activity, the production of hypoiodous acid (HOI) was quantified. HOI was detected by reacting it with ...


US Patent US9616063 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%