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Patent code US9616064

Compile Data Set for Download or QSAR
Found 137 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316103
PNG
(US9616064, Compound 30b)
Show SMILES COc1cccc(CNC(=O)c2cccc3n(ccc23)-c2ccnc(N)n2)c1
Show InChI InChI=1S/C21H19N5O2/c1-28-15-5-2-4-14(12-15)13-24-20(27)17-6-3-7-18-16(17)9-11-26(18)19-8-10-23-21(22)25-19/h2-12H,13H2,1H3,(H,24,27)(H2,22,23,25)
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n/an/a 40n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316107
PNG
(US9616064, Compound 30g | US9616064, Compound 30h)
Show SMILES CC(NC(=O)c1cccc2n(ccc12)-c1ccnc(N)n1)c1ccccc1
Show InChI InChI=1S/C21H19N5O/c1-14(15-6-3-2-4-7-15)24-20(27)17-8-5-9-18-16(17)11-13-26(18)19-10-12-23-21(22)25-19/h2-14H,1H3,(H,24,27)(H2,22,23,25)
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n/an/a 60n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316107
PNG
(US9616064, Compound 30g | US9616064, Compound 30h)
Show SMILES CC(NC(=O)c1cccc2n(ccc12)-c1ccnc(N)n1)c1ccccc1
Show InChI InChI=1S/C21H19N5O/c1-14(15-6-3-2-4-7-15)24-20(27)17-8-5-9-18-16(17)11-13-26(18)19-10-12-23-21(22)25-19/h2-14H,1H3,(H,24,27)(H2,22,23,25)
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n/an/a 120n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316103
PNG
(US9616064, Compound 30b)
Show SMILES COc1cccc(CNC(=O)c2cccc3n(ccc23)-c2ccnc(N)n2)c1
Show InChI InChI=1S/C21H19N5O2/c1-28-15-5-2-4-14(12-15)13-24-20(27)17-6-3-7-18-16(17)9-11-26(18)19-8-10-23-21(22)25-19/h2-12H,13H2,1H3,(H,24,27)(H2,22,23,25)
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n/an/a 150n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316081
PNG
(US9616064, Compound 13o)
Show SMILES CC1Cc2cc(F)ccc2N1c1ccnc(N)n1
Show InChI InChI=1S/C13H13FN4/c1-8-6-9-7-10(14)2-3-11(9)18(8)12-4-5-16-13(15)17-12/h2-5,7-8H,6H2,1H3,(H2,15,16,17)
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n/an/a 200n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316091
PNG
(US9616064, Compound 24b)
Show SMILES Nc1nccc(n1)-n1ccc2c(cccc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C20H17N5O/c21-20-22-11-9-18(24-20)25-12-10-15-16(7-4-8-17(15)25)19(26)23-13-14-5-2-1-3-6-14/h1-12H,13H2,(H,23,26)(H2,21,22,24)
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H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316107
PNG
(US9616064, Compound 30g | US9616064, Compound 30h)
Show SMILES CC(NC(=O)c1cccc2n(ccc12)-c1ccnc(N)n1)c1ccccc1
Show InChI InChI=1S/C21H19N5O/c1-14(15-6-3-2-4-7-15)24-20(27)17-8-5-9-18-16(17)11-13-26(18)19-10-12-23-21(22)25-19/h2-14H,1H3,(H,24,27)(H2,22,23,25)
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n/an/a 210n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316125
PNG
(US9616064, Compound 30w)
Show SMILES COc1cccc(c1)[C@@H](C)NC(=O)c1cccc2n(ccc12)-c1ccnc(N)n1
Show InChI InChI=1S/C22H21N5O2/c1-14(15-5-3-6-16(13-15)29-2)25-21(28)18-7-4-8-19-17(18)10-12-27(19)20-9-11-24-22(23)26-20/h3-14H,1-2H3,(H,25,28)(H2,23,24,26)/t14-/m1/s1
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n/an/a 213n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316128
PNG
(US9616064, Compound 13r)
Show SMILES COc1cccc(CNC(=O)c2cccc3N(CCc23)c2ccnc(N)n2)c1
Show InChI InChI=1S/C21H21N5O2/c1-28-15-5-2-4-14(12-15)13-24-20(27)17-6-3-7-18-16(17)9-11-26(18)19-8-10-23-21(22)25-19/h2-8,10,12H,9,11,13H2,1H3,(H,24,27)(H2,22,23,25)
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H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316088
PNG
(US9616064, Compound 15f)
Show SMILES COc1ccc2n(ccc2c1)-c1ccnc(N)n1
Show InChI InChI=1S/C13H12N4O/c1-18-10-2-3-11-9(8-10)5-7-17(11)12-4-6-15-13(14)16-12/h2-8H,1H3,(H2,14,15,16)
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H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316097
PNG
(US9616064, Compound 13q)
Show SMILES Nc1nccc(n1)N1CCc2c1cccc2OCc1ccccc1
Show InChI InChI=1S/C19H18N4O/c20-19-21-11-9-18(22-19)23-12-10-15-16(23)7-4-8-17(15)24-13-14-5-2-1-3-6-14/h1-9,11H,10,12-13H2,(H2,20,21,22)
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H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316105
PNG
(US9616064, Compound 30d)
Show SMILES Nc1nccc(n1)-n1ccc2c(cccc12)C(=O)NCc1cccc(F)c1
Show InChI InChI=1S/C20H16FN5O/c21-14-4-1-3-13(11-14)12-24-19(27)16-5-2-6-17-15(16)8-10-26(17)18-7-9-23-20(22)25-18/h1-11H,12H2,(H,24,27)(H2,22,23,25)
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H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316096
PNG
(US9616064, Compound 27e)
Show SMILES Nc1nccc(n1)-n1ccc2cc(ccc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C20H17N5O/c21-20-22-10-8-18(24-20)25-11-9-15-12-16(6-7-17(15)25)19(26)23-13-14-4-2-1-3-5-14/h1-12H,13H2,(H,23,26)(H2,21,22,24)
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H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316076
PNG
(US9616064, Compound 13i)
Show SMILES CC1Cc2cc(ccc2N1c1ccnc(N)n1)[N+]([O-])=O
Show InChI InChI=1S/C13H13N5O2/c1-8-6-9-7-10(18(19)20)2-3-11(9)17(8)12-4-5-15-13(14)16-12/h2-5,7-8H,6H2,1H3,(H2,14,15,16)
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H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316081
PNG
(US9616064, Compound 13o)
Show SMILES CC1Cc2cc(F)ccc2N1c1ccnc(N)n1
Show InChI InChI=1S/C13H13FN4/c1-8-6-9-7-10(14)2-3-11(9)18(8)12-4-5-16-13(15)17-12/h2-5,7-8H,6H2,1H3,(H2,15,16,17)
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H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316087
PNG
(US9616064, Compound 21a)
Show SMILES Nc1nccc(n1)-n1ccc2c(OCc3ccccc3)cccc12
Show InChI InChI=1S/C19H16N4O/c20-19-21-11-9-18(22-19)23-12-10-15-16(23)7-4-8-17(15)24-13-14-5-2-1-3-6-14/h1-12H,13H2,(H2,20,21,22)
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H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316088
PNG
(US9616064, Compound 15f)
Show SMILES COc1ccc2n(ccc2c1)-c1ccnc(N)n1
Show InChI InChI=1S/C13H12N4O/c1-18-10-2-3-11-9(8-10)5-7-17(11)12-4-6-15-13(14)16-12/h2-8H,1H3,(H2,14,15,16)
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H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316100
PNG
(US9616064, Compound 21e)
Show SMILES Nc1nccc(n1)-n1ccc2c(OCc3ccc(Cl)cc3)cccc12
Show InChI InChI=1S/C19H15ClN4O/c20-14-6-4-13(5-7-14)12-25-17-3-1-2-16-15(17)9-11-24(16)18-8-10-22-19(21)23-18/h1-11H,12H2,(H2,21,22,23)
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H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316097
PNG
(US9616064, Compound 13q)
Show SMILES Nc1nccc(n1)N1CCc2c1cccc2OCc1ccccc1
Show InChI InChI=1S/C19H18N4O/c20-19-21-11-9-18(22-19)23-12-10-15-16(23)7-4-8-17(15)24-13-14-5-2-1-3-6-14/h1-9,11H,10,12-13H2,(H2,20,21,22)
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n/an/a 480n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316092
PNG
(US9616064, Compound 24c)
Show SMILES Nc1nccc(n1)-n1ccc2c(cccc12)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C21H19N5O/c22-21-24-13-10-19(25-21)26-14-11-16-17(7-4-8-18(16)26)20(27)23-12-9-15-5-2-1-3-6-15/h1-8,10-11,13-14H,9,12H2,(H,23,27)(H2,22,24,25)
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H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316076
PNG
(US9616064, Compound 13i)
Show SMILES CC1Cc2cc(ccc2N1c1ccnc(N)n1)[N+]([O-])=O
Show InChI InChI=1S/C13H13N5O2/c1-8-6-9-7-10(18(19)20)2-3-11(9)17(8)12-4-5-15-13(14)16-12/h2-5,7-8H,6H2,1H3,(H2,14,15,16)
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H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316079
PNG
(US9616064, Compound 13m)
Show SMILES CC1Cc2cc(Cl)ccc2N1c1ccnc(N)n1
Show InChI InChI=1S/C13H13ClN4/c1-8-6-9-7-10(14)2-3-11(9)18(8)12-4-5-16-13(15)17-12/h2-5,7-8H,6H2,1H3,(H2,15,16,17)
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n/an/a 500n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316074
PNG
(US9616064, Compound 13f)
Show SMILES Nc1nccc(n1)N1CCc2cc(F)ccc12
Show InChI InChI=1S/C12H11FN4/c13-9-1-2-10-8(7-9)4-6-17(10)11-3-5-15-12(14)16-11/h1-3,5,7H,4,6H2,(H2,14,15,16)
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n/an/a 700n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316095
PNG
(US9616064, Compound 27d)
Show SMILES Nc1nccc(n1)-n1ccc2cc(ccc12)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C21H19N5O/c22-21-24-12-9-19(25-21)26-13-10-16-14-17(6-7-18(16)26)20(27)23-11-8-15-4-2-1-3-5-15/h1-7,9-10,12-14H,8,11H2,(H,23,27)(H2,22,24,25)
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n/an/a 700n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316104
PNG
(US9616064, Compound 30c)
Show SMILES Nc1nccc(n1)-n1ccc2c(cccc12)C(=O)NCc1cccc(Cl)c1
Show InChI InChI=1S/C20H16ClN5O/c21-14-4-1-3-13(11-14)12-24-19(27)16-5-2-6-17-15(16)8-10-26(17)18-7-9-23-20(22)25-18/h1-11H,12H2,(H,24,27)(H2,22,23,25)
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n/an/a 720n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316087
PNG
(US9616064, Compound 21a)
Show SMILES Nc1nccc(n1)-n1ccc2c(OCc3ccccc3)cccc12
Show InChI InChI=1S/C19H16N4O/c20-19-21-11-9-18(22-19)23-12-10-15-16(23)7-4-8-17(15)24-13-14-5-2-1-3-6-14/h1-12H,13H2,(H2,20,21,22)
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n/an/a 800n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316111
PNG
(US9616064, Compound 30k)
Show SMILES Nc1nccc(n1)-n1ccc2c(cccc12)C(=O)NCc1ccccc1F
Show InChI InChI=1S/C20H16FN5O/c21-16-6-2-1-4-13(16)12-24-19(27)15-5-3-7-17-14(15)9-11-26(17)18-8-10-23-20(22)25-18/h1-11H,12H2,(H,24,27)(H2,22,23,25)
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n/an/a 920n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50429636
PNG
(CHEMBL2334964 | US9616064, Compound 15d)
Show SMILES Nc1nccc(n1)-n1ccc2ccc(Cl)cc12
Show InChI InChI=1S/C12H9ClN4/c13-9-2-1-8-4-6-17(10(8)7-9)11-3-5-15-12(14)16-11/h1-7H,(H2,14,15,16)
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n/an/a 1.00E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316091
PNG
(US9616064, Compound 24b)
Show SMILES Nc1nccc(n1)-n1ccc2c(cccc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C20H17N5O/c21-20-22-11-9-18(24-20)25-12-10-15-16(7-4-8-17(15)25)19(26)23-13-14-5-2-1-3-6-14/h1-12H,13H2,(H,23,26)(H2,21,22,24)
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n/an/a 1.00E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316106
PNG
(US9616064, Compound 30f)
Show SMILES Nc1nccc(n1)-n1ccc2c(cccc12)C(=O)NCc1ccc(F)cc1
Show InChI InChI=1S/C20H16FN5O/c21-14-6-4-13(5-7-14)12-24-19(27)16-2-1-3-17-15(16)9-11-26(17)18-8-10-23-20(22)25-18/h1-11H,12H2,(H,24,27)(H2,22,23,25)
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n/an/a 1.10E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316077
PNG
(US9616064, Compound 13j)
Show SMILES Nc1nccc(n1)N1CCc2cc(Br)ccc12
Show InChI InChI=1S/C12H11BrN4/c13-9-1-2-10-8(7-9)4-6-17(10)11-3-5-15-12(14)16-11/h1-3,5,7H,4,6H2,(H2,14,15,16)
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n/an/a 1.20E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM50429636
PNG
(CHEMBL2334964 | US9616064, Compound 15d)
Show SMILES Nc1nccc(n1)-n1ccc2ccc(Cl)cc12
Show InChI InChI=1S/C12H9ClN4/c13-9-2-1-8-4-6-17(10(8)7-9)11-3-5-15-12(14)16-11/h1-7H,(H2,14,15,16)
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n/an/a 1.20E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316074
PNG
(US9616064, Compound 13f)
Show SMILES Nc1nccc(n1)N1CCc2cc(F)ccc12
Show InChI InChI=1S/C12H11FN4/c13-9-1-2-10-8(7-9)4-6-17(10)11-3-5-15-12(14)16-11/h1-3,5,7H,4,6H2,(H2,14,15,16)
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n/an/a 1.20E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316070
PNG
(US9616064, Compound 13c)
Show SMILES Nc1nccc(n1)N1CCc2cc(Cl)ccc12
Show InChI InChI=1S/C12H11ClN4/c13-9-1-2-10-8(7-9)4-6-17(10)11-3-5-15-12(14)16-11/h1-3,5,7H,4,6H2,(H2,14,15,16)
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n/an/a 1.20E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316079
PNG
(US9616064, Compound 13m)
Show SMILES CC1Cc2cc(Cl)ccc2N1c1ccnc(N)n1
Show InChI InChI=1S/C13H13ClN4/c1-8-6-9-7-10(14)2-3-11(9)18(8)12-4-5-16-13(15)17-12/h2-5,7-8H,6H2,1H3,(H2,15,16,17)
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n/an/a 1.20E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316110
PNG
(US9616064, Compound 30j)
Show SMILES C[C@H](NC(=O)c1cccc2n(ccc12)-c1ccnc(N)n1)c1ccccc1
Show InChI InChI=1S/C21H19N5O/c1-14(15-6-3-2-4-7-15)24-20(27)17-8-5-9-18-16(17)11-13-26(18)19-10-12-23-21(22)25-19/h2-14H,1H3,(H,24,27)(H2,22,23,25)/t14-/m0/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316082
PNG
(US9616064, Compound 13p)
Show SMILES Nc1nccc(n1)N1CCc2ccc(F)cc12
Show InChI InChI=1S/C12H11FN4/c13-9-2-1-8-4-6-17(10(8)7-9)11-3-5-15-12(14)16-11/h1-3,5,7H,4,6H2,(H2,14,15,16)
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n/an/a 1.34E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316126
PNG
(US9616064, Compound 30z)
Show SMILES COc1cccc(c1)[C@H](C)NC(=O)c1cccc2n(ccc12)-c1ccnc(N)n1
Show InChI InChI=1S/C22H21N5O2/c1-14(15-5-3-6-16(13-15)29-2)25-21(28)18-7-4-8-19-17(18)10-12-27(19)20-9-11-24-22(23)26-20/h3-14H,1-2H3,(H,25,28)(H2,23,24,26)/t14-/m0/s1
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n/an/a 1.38E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316114
PNG
(US9616064, Compound 30n)
Show SMILES CC(=O)Nc1cccc(CNC(=O)c2cccc3n(ccc23)-c2ccnc(N)n2)c1
Show InChI InChI=1S/C22H20N6O2/c1-14(29)26-16-5-2-4-15(12-16)13-25-21(30)18-6-3-7-19-17(18)9-11-28(19)20-8-10-24-22(23)27-20/h2-12H,13H2,1H3,(H,25,30)(H,26,29)(H2,23,24,27)
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n/an/a 1.39E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316070
PNG
(US9616064, Compound 13c)
Show SMILES Nc1nccc(n1)N1CCc2cc(Cl)ccc12
Show InChI InChI=1S/C12H11ClN4/c13-9-1-2-10-8(7-9)4-6-17(10)11-3-5-15-12(14)16-11/h1-3,5,7H,4,6H2,(H2,14,15,16)
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n/an/a 1.50E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316128
PNG
(US9616064, Compound 13r)
Show SMILES COc1cccc(CNC(=O)c2cccc3N(CCc23)c2ccnc(N)n2)c1
Show InChI InChI=1S/C21H21N5O2/c1-28-15-5-2-4-14(12-15)13-24-20(27)17-6-3-7-18-16(17)9-11-26(18)19-8-10-23-21(22)25-19/h2-8,10,12H,9,11,13H2,1H3,(H,24,27)(H2,22,23,25)
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n/an/a 1.62E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316065
PNG
(US9616064, Compound 13b)
Show SMILES CC1Cc2ccccc2N1c1ccnc(N)n1
Show InChI InChI=1S/C13H14N4/c1-9-8-10-4-2-3-5-11(10)17(9)12-6-7-15-13(14)16-12/h2-7,9H,8H2,1H3,(H2,14,15,16)
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n/an/a 1.70E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316107
PNG
(US9616064, Compound 30g | US9616064, Compound 30h)
Show SMILES CC(NC(=O)c1cccc2n(ccc12)-c1ccnc(N)n1)c1ccccc1
Show InChI InChI=1S/C21H19N5O/c1-14(15-6-3-2-4-7-15)24-20(27)17-8-5-9-18-16(17)11-13-26(18)19-10-12-23-21(22)25-19/h2-14H,1H3,(H,24,27)(H2,22,23,25)
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n/an/a 1.70E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316077
PNG
(US9616064, Compound 13j)
Show SMILES Nc1nccc(n1)N1CCc2cc(Br)ccc12
Show InChI InChI=1S/C12H11BrN4/c13-9-1-2-10-8(7-9)4-6-17(10)11-3-5-15-12(14)16-11/h1-3,5,7H,4,6H2,(H2,14,15,16)
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n/an/a 1.70E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316084
PNG
(US9616064, Compound 15c)
Show SMILES Nc1nccc(n1)-n1ccc2cc(Br)ccc12
Show InChI InChI=1S/C12H9BrN4/c13-9-1-2-10-8(7-9)4-6-17(10)11-3-5-15-12(14)16-11/h1-7H,(H2,14,15,16)
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n/an/a 1.70E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50432360
PNG
(CHEMBL2348175 | US9616064, Compound 15b)
Show SMILES Nc1nccc(n1)-n1ccc2ccc(F)cc12
Show InChI InChI=1S/C12H9FN4/c13-9-2-1-8-4-6-17(10(8)7-9)11-3-5-15-12(14)16-11/h1-7H,(H2,14,15,16)
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n/an/a 1.70E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316115
PNG
(US9616064, Compound 30o)
Show SMILES CC[C@@H](NC(=O)c1cccc2n(ccc12)-c1ccnc(N)n1)c1ccccc1
Show InChI InChI=1S/C22H21N5O/c1-2-18(15-7-4-3-5-8-15)25-21(28)17-9-6-10-19-16(17)12-14-27(19)20-11-13-24-22(23)26-20/h3-14,18H,2H2,1H3,(H,25,28)(H2,23,24,26)/t18-/m1/s1
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n/an/a 1.77E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316073
PNG
(US9616064, Compound 13d)
Show SMILES Nc1nccc(n1)N1CCc2ccc(cc12)[N+]([O-])=O
Show InChI InChI=1S/C12H11N5O2/c13-12-14-5-3-11(15-12)16-6-4-8-1-2-9(17(18)19)7-10(8)16/h1-3,5,7H,4,6H2,(H2,13,14,15)
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n/an/a 1.80E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316109
PNG
(US9616064, Compound 30i)
Show SMILES COc1ccccc1CNC(=O)c1cccc2n(ccc12)-c1ccnc(N)n1
Show InChI InChI=1S/C21H19N5O2/c1-28-18-8-3-2-5-14(18)13-24-20(27)16-6-4-7-17-15(16)10-12-26(17)19-9-11-23-21(22)25-19/h2-12H,13H2,1H3,(H,24,27)(H2,22,23,25)
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n/an/a 1.80E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316065
PNG
(US9616064, Compound 13b)
Show SMILES CC1Cc2ccccc2N1c1ccnc(N)n1
Show InChI InChI=1S/C13H14N4/c1-9-8-10-4-2-3-5-11(10)17(9)12-6-7-15-13(14)16-12/h2-7,9H,8H2,1H3,(H2,14,15,16)
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n/an/a 1.90E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316100
PNG
(US9616064, Compound 21e)
Show SMILES Nc1nccc(n1)-n1ccc2c(OCc3ccc(Cl)cc3)cccc12
Show InChI InChI=1S/C19H15ClN4O/c20-14-6-4-13(5-7-14)12-25-17-3-1-2-16-15(17)9-11-24(16)18-8-10-22-19(21)23-18/h1-11H,12H2,(H2,21,22,23)
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n/an/a 1.90E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316092
PNG
(US9616064, Compound 24c)
Show SMILES Nc1nccc(n1)-n1ccc2c(cccc12)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C21H19N5O/c22-21-24-13-10-19(25-21)26-14-11-16-17(7-4-8-18(16)26)20(27)23-12-9-15-5-2-1-3-6-15/h1-8,10-11,13-14H,9,12H2,(H,23,27)(H2,22,24,25)
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n/an/a 2.00E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316084
PNG
(US9616064, Compound 15c)
Show SMILES Nc1nccc(n1)-n1ccc2cc(Br)ccc12
Show InChI InChI=1S/C12H9BrN4/c13-9-1-2-10-8(7-9)4-6-17(10)11-3-5-15-12(14)16-11/h1-7H,(H2,14,15,16)
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n/an/a 2.10E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316073
PNG
(US9616064, Compound 13d)
Show SMILES Nc1nccc(n1)N1CCc2ccc(cc12)[N+]([O-])=O
Show InChI InChI=1S/C12H11N5O2/c13-12-14-5-3-11(15-12)16-6-4-8-1-2-9(17(18)19)7-10(8)16/h1-3,5,7H,4,6H2,(H2,13,14,15)
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n/an/a 2.20E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316096
PNG
(US9616064, Compound 27e)
Show SMILES Nc1nccc(n1)-n1ccc2cc(ccc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C20H17N5O/c21-20-22-10-8-18(24-20)25-11-9-15-12-16(6-7-17(15)25)19(26)23-13-14-4-2-1-3-5-14/h1-12H,13H2,(H,23,26)(H2,21,22,24)
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n/an/a 2.40E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316078
PNG
(US9616064, Compound 13l)
Show SMILES CC1CN(c2ccccc12)c1ccnc(N)n1
Show InChI InChI=1S/C13H14N4/c1-9-8-17(11-5-3-2-4-10(9)11)12-6-7-15-13(14)16-12/h2-7,9H,8H2,1H3,(H2,14,15,16)
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n/an/a 2.60E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316105
PNG
(US9616064, Compound 30d)
Show SMILES Nc1nccc(n1)-n1ccc2c(cccc12)C(=O)NCc1cccc(F)c1
Show InChI InChI=1S/C20H16FN5O/c21-14-4-1-3-13(11-14)12-24-19(27)16-5-2-6-17-15(16)8-10-26(17)18-7-9-23-20(22)25-18/h1-11H,12H2,(H,24,27)(H2,22,23,25)
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n/an/a 2.70E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316095
PNG
(US9616064, Compound 27d)
Show SMILES Nc1nccc(n1)-n1ccc2cc(ccc12)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C21H19N5O/c22-21-24-12-9-19(25-21)26-13-10-16-14-17(6-7-18(16)26)20(27)23-11-8-15-4-2-1-3-5-15/h1-7,9-10,12-14H,8,11H2,(H,23,27)(H2,22,24,25)
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n/an/a 2.80E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316113
PNG
(US9616064, Compound 30m)
Show SMILES CS(=O)(=O)Nc1cccc(CNC(=O)c2cccc3n(ccc23)-c2ccnc(N)n2)c1
Show InChI InChI=1S/C21H20N6O3S/c1-31(29,30)26-15-5-2-4-14(12-15)13-24-20(28)17-6-3-7-18-16(17)9-11-27(18)19-8-10-23-21(22)25-19/h2-12,26H,13H2,1H3,(H,24,28)(H2,22,23,25)
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n/an/a 3.26E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316120
PNG
(US9616064, Compound 3s)
Show SMILES CCOc1cccc(CNC(=O)c2cccc3n(ccc23)-c2ccnc(N)n2)c1
Show InChI InChI=1S/C22H21N5O2/c1-2-29-16-6-3-5-15(13-16)14-25-21(28)18-7-4-8-19-17(18)10-12-27(19)20-9-11-24-22(23)26-20/h3-13H,2,14H2,1H3,(H,25,28)(H2,23,24,26)
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n/an/a 3.37E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316060
PNG
(US9616064, Compound 13a)
Show SMILES Nc1nccc(n1)N1CCc2ccccc12
Show InChI InChI=1S/C12H12N4/c13-12-14-7-5-11(15-12)16-8-6-9-3-1-2-4-10(9)16/h1-5,7H,6,8H2,(H2,13,14,15)
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n/an/a 3.40E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316110
PNG
(US9616064, Compound 30j)
Show SMILES C[C@H](NC(=O)c1cccc2n(ccc12)-c1ccnc(N)n1)c1ccccc1
Show InChI InChI=1S/C21H19N5O/c1-14(15-6-3-2-4-7-15)24-20(27)17-8-5-9-18-16(17)11-13-26(18)19-10-12-23-21(22)25-19/h2-14H,1H3,(H,24,27)(H2,22,23,25)/t14-/m0/s1
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n/an/a 3.43E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316082
PNG
(US9616064, Compound 13p)
Show SMILES Nc1nccc(n1)N1CCc2ccc(F)cc12
Show InChI InChI=1S/C12H11FN4/c13-9-2-1-8-4-6-17(10(8)7-9)11-3-5-15-12(14)16-11/h1-3,5,7H,4,6H2,(H2,14,15,16)
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n/an/a 3.70E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316066
PNG
(US9616064, Compound 1bb)
Show SMILES Nc1nccc(Nc2ccc(cc2)[N+]([O-])=O)n1
Show InChI InChI=1S/C10H9N5O2/c11-10-12-6-5-9(14-10)13-7-1-3-8(4-2-7)15(16)17/h1-6H,(H3,11,12,13,14)
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n/an/a 3.70E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316066
PNG
(US9616064, Compound 1bb)
Show SMILES Nc1nccc(Nc2ccc(cc2)[N+]([O-])=O)n1
Show InChI InChI=1S/C10H9N5O2/c11-10-12-6-5-9(14-10)13-7-1-3-8(4-2-7)15(16)17/h1-6H,(H3,11,12,13,14)
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n/an/a 3.90E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50432338
PNG
(CHEMBL2348176 | US9616064, Compound 15a)
Show SMILES Nc1nccc(n1)-n1ccc2ccccc12
Show InChI InChI=1S/C12H10N4/c13-12-14-7-5-11(15-12)16-8-6-9-3-1-2-4-10(9)16/h1-8H,(H2,13,14,15)
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n/an/a 4.00E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM50432338
PNG
(CHEMBL2348176 | US9616064, Compound 15a)
Show SMILES Nc1nccc(n1)-n1ccc2ccccc12
Show InChI InChI=1S/C12H10N4/c13-12-14-7-5-11(15-12)16-8-6-9-3-1-2-4-10(9)16/h1-8H,(H2,13,14,15)
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n/an/a 4.80E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316078
PNG
(US9616064, Compound 13l)
Show SMILES CC1CN(c2ccccc12)c1ccnc(N)n1
Show InChI InChI=1S/C13H14N4/c1-9-8-17(11-5-3-2-4-10(9)11)12-6-7-15-13(14)16-12/h2-7,9H,8H2,1H3,(H2,14,15,16)
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n/an/a 4.80E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316067
PNG
(US9616064, Compound 6)
Show SMILES Nc1nccc(Nc2cccc(c2)[N+]([O-])=O)n1
Show InChI InChI=1S/C10H9N5O2/c11-10-12-5-4-9(14-10)13-7-2-1-3-8(6-7)15(16)17/h1-6H,(H3,11,12,13,14)
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n/an/a 4.86E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316086
PNG
(US9616064, Compound 15e)
Show SMILES COc1ccc2ccn(-c3ccnc(N)n3)c2c1
Show InChI InChI=1S/C13H12N4O/c1-18-10-3-2-9-5-7-17(11(9)8-10)12-4-6-15-13(14)16-12/h2-8H,1H3,(H2,14,15,16)
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n/an/a 4.90E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316090
PNG
(US9616064, Compound 15h)
Show SMILES COc1ccc2n(cc(CCNC(C)=O)c2c1)-c1ccnc(N)n1
Show InChI InChI=1S/C17H19N5O2/c1-11(23)19-7-5-12-10-22(16-6-8-20-17(18)21-16)15-4-3-13(24-2)9-14(12)15/h3-4,6,8-10H,5,7H2,1-2H3,(H,19,23)(H2,18,20,21)
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n/an/a 4.90E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM50432360
PNG
(CHEMBL2348175 | US9616064, Compound 15b)
Show SMILES Nc1nccc(n1)-n1ccc2ccc(F)cc12
Show InChI InChI=1S/C12H9FN4/c13-9-2-1-8-4-6-17(10(8)7-9)11-3-5-15-12(14)16-11/h1-7H,(H2,14,15,16)
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US Patent
n/an/a 4.90E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316086
PNG
(US9616064, Compound 15e)
Show SMILES COc1ccc2ccn(-c3ccnc(N)n3)c2c1
Show InChI InChI=1S/C13H12N4O/c1-18-10-3-2-9-5-7-17(11(9)8-10)12-4-6-15-13(14)16-12/h2-8H,1H3,(H2,14,15,16)
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n/an/a 4.90E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316090
PNG
(US9616064, Compound 15h)
Show SMILES COc1ccc2n(cc(CCNC(C)=O)c2c1)-c1ccnc(N)n1
Show InChI InChI=1S/C17H19N5O2/c1-11(23)19-7-5-12-10-22(16-6-8-20-17(18)21-16)15-4-3-13(24-2)9-14(12)15/h3-4,6,8-10H,5,7H2,1-2H3,(H,19,23)(H2,18,20,21)
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n/an/a 5.30E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316111
PNG
(US9616064, Compound 30k)
Show SMILES Nc1nccc(n1)-n1ccc2c(cccc12)C(=O)NCc1ccccc1F
Show InChI InChI=1S/C20H16FN5O/c21-16-6-2-1-4-13(16)12-24-19(27)15-5-3-7-17-14(15)9-11-26(17)18-8-10-23-20(22)25-18/h1-11H,12H2,(H,24,27)(H2,22,23,25)
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n/an/a 5.67E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316127
PNG
(US9616064, Compound 1bj)
Show SMILES Nc1nccc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C10H9ClN4/c11-7-2-1-3-8(6-7)14-9-4-5-13-10(12)15-9/h1-6H,(H3,12,13,14,15)
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n/an/a 5.71E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316093
PNG
(US9616064, Compound 27a)
Show SMILES Nc1nccc(n1)-n1ccc2cc(NC(=O)Cc3ccccc3)ccc12
Show InChI InChI=1S/C20H17N5O/c21-20-22-10-8-18(24-20)25-11-9-15-13-16(6-7-17(15)25)23-19(26)12-14-4-2-1-3-5-14/h1-11,13H,12H2,(H,23,26)(H2,21,22,24)
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n/an/a 5.80E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316109
PNG
(US9616064, Compound 30i)
Show SMILES COc1ccccc1CNC(=O)c1cccc2n(ccc12)-c1ccnc(N)n1
Show InChI InChI=1S/C21H19N5O2/c1-28-18-8-3-2-5-14(18)13-24-20(27)16-6-4-7-17-15(16)10-12-26(17)19-9-11-23-21(22)25-19/h2-12H,13H2,1H3,(H,24,27)(H2,22,23,25)
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n/an/a 6.00E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM314082
PNG
(US9616064, Compound 1ag)
Show SMILES Nc1nccc(Nc2cccc(c2)S(N)(=O)=O)n1
Show InChI InChI=1S/C10H11N5O2S/c11-10-13-5-4-9(15-10)14-7-2-1-3-8(6-7)18(12,16)17/h1-6H,(H2,12,16,17)(H3,11,13,14,15)
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n/an/a 6.10E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM314082
PNG
(US9616064, Compound 1ag)
Show SMILES Nc1nccc(Nc2cccc(c2)S(N)(=O)=O)n1
Show InChI InChI=1S/C10H11N5O2S/c11-10-13-5-4-9(15-10)14-7-2-1-3-8(6-7)18(12,16)17/h1-6H,(H2,12,16,17)(H3,11,13,14,15)
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n/an/a 6.10E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316060
PNG
(US9616064, Compound 13a)
Show SMILES Nc1nccc(n1)N1CCc2ccccc12
Show InChI InChI=1S/C12H12N4/c13-12-14-7-5-11(15-12)16-8-6-9-3-1-2-4-10(9)16/h1-5,7H,6,8H2,(H2,13,14,15)
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n/an/a 6.60E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316059
PNG
(US9616064, Compound 1an)
Show SMILES CS(=O)(=O)c1cccc(Nc2ccnc(N)n2)c1
Show InChI InChI=1S/C11H12N4O2S/c1-18(16,17)9-4-2-3-8(7-9)14-10-5-6-13-11(12)15-10/h2-7H,1H3,(H3,12,13,14,15)
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n/an/a 6.70E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316104
PNG
(US9616064, Compound 30c)
Show SMILES Nc1nccc(n1)-n1ccc2c(cccc12)C(=O)NCc1cccc(Cl)c1
Show InChI InChI=1S/C20H16ClN5O/c21-14-4-1-3-13(11-14)12-24-19(27)16-5-2-6-17-15(16)8-10-26(17)18-7-9-23-20(22)25-18/h1-11H,12H2,(H,24,27)(H2,22,23,25)
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n/an/a 6.80E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316089
PNG
(US9616064, Compound 15g)
Show SMILES Cc1ccc2n(ccc2c1)-c1ccnc(N)n1
Show InChI InChI=1S/C13H12N4/c1-9-2-3-11-10(8-9)5-7-17(11)12-4-6-15-13(14)16-12/h2-8H,1H3,(H2,14,15,16)
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n/an/a 7.10E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316059
PNG
(US9616064, Compound 1an)
Show SMILES CS(=O)(=O)c1cccc(Nc2ccnc(N)n2)c1
Show InChI InChI=1S/C11H12N4O2S/c1-18(16,17)9-4-2-3-8(7-9)14-10-5-6-13-11(12)15-10/h2-7H,1H3,(H3,12,13,14,15)
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n/an/a 7.30E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316123
PNG
(US9616064, Compound 46)
Show SMILES COc1cccc(CNC(=O)c2cccc(Nc3ccnc(N)n3)c2)c1
Show InChI InChI=1S/C19H19N5O2/c1-26-16-7-2-4-13(10-16)12-22-18(25)14-5-3-6-15(11-14)23-17-8-9-21-19(20)24-17/h2-11H,12H2,1H3,(H,22,25)(H3,20,21,23,24)
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n/an/a 7.30E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316067
PNG
(US9616064, Compound 6)
Show SMILES Nc1nccc(Nc2cccc(c2)[N+]([O-])=O)n1
Show InChI InChI=1S/C10H9N5O2/c11-10-12-5-4-9(14-10)13-7-2-1-3-8(6-7)15(16)17/h1-6H,(H3,11,12,13,14)
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n/an/a 7.82E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316089
PNG
(US9616064, Compound 15g)
Show SMILES Cc1ccc2n(ccc2c1)-c1ccnc(N)n1
Show InChI InChI=1S/C13H12N4/c1-9-2-3-11-10(8-9)5-7-17(11)12-4-6-15-13(14)16-12/h2-8H,1H3,(H2,14,15,16)
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n/an/a 8.30E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316122
PNG
(US9616064, Compound 30v)
Show SMILES Nc1nccc(n1)-n1ccc2c(cccc12)C(=O)NCc1cccc(c1)N1CCCC1=O
Show InChI InChI=1S/C24H22N6O2/c25-24-26-11-9-21(28-24)30-13-10-18-19(6-2-7-20(18)30)23(32)27-15-16-4-1-5-17(14-16)29-12-3-8-22(29)31/h1-2,4-7,9-11,13-14H,3,8,12,15H2,(H,27,32)(H2,25,26,28)
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n/an/a 8.31E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316094
PNG
(US9616064, Compound 27c)
Show SMILES Nc1nccc(n1)-n1ccc2cc(NC(=O)CCc3ccccc3)ccc12
Show InChI InChI=1S/C21H19N5O/c22-21-23-12-10-19(25-21)26-13-11-16-14-17(7-8-18(16)26)24-20(27)9-6-15-4-2-1-3-5-15/h1-5,7-8,10-14H,6,9H2,(H,24,27)(H2,22,23,25)
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n/an/a 8.40E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316119
PNG
(US9616064, Compound 30r)
Show SMILES COCCOc1cccc(CNC(=O)c2cccc3n(ccc23)-c2ccnc(N)n2)c1
Show InChI InChI=1S/C23H23N5O3/c1-30-12-13-31-17-5-2-4-16(14-17)15-26-22(29)19-6-3-7-20-18(19)9-11-28(20)21-8-10-25-23(24)27-21/h2-11,14H,12-13,15H2,1H3,(H,26,29)(H2,24,25,27)
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n/an/a 9.31E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316129
PNG
(US9616064, Compound 30aa)
Show SMILES CC[C@H](NC(=O)c1cccc2n(ccc12)-c1ccnc(N)n1)c1ccccc1
Show InChI InChI=1S/C22H21N5O/c1-2-18(15-7-4-3-5-8-15)25-21(28)17-9-6-10-19-16(17)12-14-27(19)20-11-13-24-22(23)26-20/h3-14,18H,2H2,1H3,(H,25,28)(H2,23,24,26)/t18-/m0/s1
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n/an/a 9.76E+3n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316080
PNG
(US9616064, Compound 13n)
Show SMILES Nc1nccc(n1)N1CCc2cc(ccc12)S(N)(=O)=O
Show InChI InChI=1S/C12H13N5O2S/c13-12-15-5-3-11(16-12)17-6-4-8-7-9(20(14,18)19)1-2-10(8)17/h1-3,5,7H,4,6H2,(H2,13,15,16)(H2,14,18,19)
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n/an/a 1.03E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316106
PNG
(US9616064, Compound 30f)
Show SMILES Nc1nccc(n1)-n1ccc2c(cccc12)C(=O)NCc1ccc(F)cc1
Show InChI InChI=1S/C20H16FN5O/c21-14-6-4-13(5-7-14)12-24-19(27)16-2-1-3-17-15(16)9-11-26(17)18-8-10-23-20(22)25-18/h1-11H,12H2,(H,24,27)(H2,22,23,25)
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n/an/a 1.05E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM314083
PNG
(US9616064, Compound 1ah)
Show SMILES NC(=O)c1ccc(Nc2ccnc(N)n2)cc1
Show InChI InChI=1S/C11H11N5O/c12-10(17)7-1-3-8(4-2-7)15-9-5-6-14-11(13)16-9/h1-6H,(H2,12,17)(H3,13,14,15,16)
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n/an/a 1.15E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316112
PNG
(US9616064, Compound 27d)
Show SMILES COc1cccc(CC(=O)Nc2cccc3n(ccc23)-c2ccnc(N)n2)c1
Show InChI InChI=1S/C21H19N5O2/c1-28-15-5-2-4-14(12-15)13-20(27)24-17-6-3-7-18-16(17)9-11-26(18)19-8-10-23-21(22)25-19/h2-12H,13H2,1H3,(H,24,27)(H2,22,23,25)
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n/an/a 1.30E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM314083
PNG
(US9616064, Compound 1ah)
Show SMILES NC(=O)c1ccc(Nc2ccnc(N)n2)cc1
Show InChI InChI=1S/C11H11N5O/c12-10(17)7-1-3-8(4-2-7)15-9-5-6-14-11(13)16-9/h1-6H,(H2,12,17)(H3,13,14,15,16)
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n/an/a 1.33E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316063
PNG
(US9616064, Compound 1aw)
Show SMILES COC(=O)c1ccc(Nc2ccnc(N)n2)cc1
Show InChI InChI=1S/C12H12N4O2/c1-18-11(17)8-2-4-9(5-3-8)15-10-6-7-14-12(13)16-10/h2-7H,1H3,(H3,13,14,15,16)
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n/an/a 1.39E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316117
PNG
(US9616064, Compound 30q)
Show SMILES COc1cccc(CN(C)C(=O)c2cccc3n(ccc23)-c2ccnc(N)n2)c1
Show InChI InChI=1S/C22H21N5O2/c1-26(14-15-5-3-6-16(13-15)29-2)21(28)18-7-4-8-19-17(18)10-12-27(19)20-9-11-24-22(23)25-20/h3-13H,14H2,1-2H3,(H2,23,24,25)
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n/an/a 1.53E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316118
PNG
(US9616064, Compound 36)
Show SMILES COc1cccc(CNC(=O)c2cccc3n(ccc23)-c2ccnc(NC(C)=O)n2)c1
Show InChI InChI=1S/C23H21N5O3/c1-15(29)26-23-24-11-9-21(27-23)28-12-10-18-19(7-4-8-20(18)28)22(30)25-14-16-5-3-6-17(13-16)31-2/h3-13H,14H2,1-2H3,(H,25,30)(H,24,26,27,29)
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n/an/a 1.54E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316116
PNG
(US9616064, Compound 30p)
Show SMILES COC[C@H](NC(=O)c1cccc2n(ccc12)-c1ccnc(N)n1)c1ccccc1
Show InChI InChI=1S/C22H21N5O2/c1-29-14-18(15-6-3-2-4-7-15)25-21(28)17-8-5-9-19-16(17)11-13-27(19)20-10-12-24-22(23)26-20/h2-13,18H,14H2,1H3,(H,25,28)(H2,23,24,26)/t18-/m0/s1
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n/an/a 1.54E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316098
PNG
(US9616064, Compound 21b)
Show SMILES Nc1nccc(n1)-n1ccc2cc(OCc3ccccc3)ccc12
Show InChI InChI=1S/C19H16N4O/c20-19-21-10-8-18(22-19)23-11-9-15-12-16(6-7-17(15)23)24-13-14-4-2-1-3-5-14/h1-12H,13H2,(H2,20,21,22)
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n/an/a 1.63E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316099
PNG
(US9616064, Compound 21c)
Show SMILES Nc1nccc(n1)-n1ccc2c(OCCc3ccccc3)cccc12
Show InChI InChI=1S/C20H18N4O/c21-20-22-12-9-19(23-20)24-13-10-16-17(24)7-4-8-18(16)25-14-11-15-5-2-1-3-6-15/h1-10,12-13H,11,14H2,(H2,21,22,23)
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n/an/a 1.70E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316061
PNG
(US9616064, Compound 1au)
Show SMILES CSc1ccc(Nc2ccnc(N)n2)cc1
Show InChI InChI=1S/C11H12N4S/c1-16-9-4-2-8(3-5-9)14-10-6-7-13-11(12)15-10/h2-7H,1H3,(H3,12,13,14,15)
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n/an/a 1.71E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316102
PNG
(US9616064, Compound 21h)
Show SMILES Nc1nccc(n1)-n1ccc2c(OCc3ccccc3Cl)cccc12
Show InChI InChI=1S/C19H15ClN4O/c20-15-5-2-1-4-13(15)12-25-17-7-3-6-16-14(17)9-11-24(16)18-8-10-22-19(21)23-18/h1-11H,12H2,(H2,21,22,23)
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n/an/a 1.90E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316064
PNG
(US9616064, Compound 16)
Show SMILES Nc1nccc(n1)N1CCCc2ccccc12
Show InChI InChI=1S/C13H14N4/c14-13-15-8-7-12(16-13)17-9-3-5-10-4-1-2-6-11(10)17/h1-2,4,6-8H,3,5,9H2,(H2,14,15,16)
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n/an/a 1.98E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316063
PNG
(US9616064, Compound 1aw)
Show SMILES COC(=O)c1ccc(Nc2ccnc(N)n2)cc1
Show InChI InChI=1S/C12H12N4O2/c1-18-11(17)8-2-4-9(5-3-8)15-10-6-7-14-12(13)16-10/h2-7H,1H3,(H3,13,14,15,16)
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n/an/a 2.05E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316093
PNG
(US9616064, Compound 27a)
Show SMILES Nc1nccc(n1)-n1ccc2cc(NC(=O)Cc3ccccc3)ccc12
Show InChI InChI=1S/C20H17N5O/c21-20-22-10-8-18(24-20)25-11-9-15-13-16(6-7-17(15)25)23-19(26)12-14-4-2-1-3-5-14/h1-11,13H,12H2,(H,23,26)(H2,21,22,24)
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n/an/a 2.08E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316061
PNG
(US9616064, Compound 1au)
Show SMILES CSc1ccc(Nc2ccnc(N)n2)cc1
Show InChI InChI=1S/C11H12N4S/c1-16-9-4-2-8(3-5-9)14-10-6-7-13-11(12)15-10/h2-7H,1H3,(H3,12,13,14,15)
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n/an/a 2.10E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316069
PNG
(US9616064, Compound 1bg)
Show SMILES Nc1nccc(Nc2ccc(OC(F)F)cc2)n1
Show InChI InChI=1S/C11H10F2N4O/c12-10(13)18-8-3-1-7(2-4-8)16-9-5-6-15-11(14)17-9/h1-6,10H,(H3,14,15,16,17)
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n/an/a 2.34E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM10873
PNG
(4-[(2-aminopyrimidin-4-yl)amino]benzene-1-sulfonam...)
Show SMILES Nc1nccc(Nc2ccc(cc2)S(N)(=O)=O)n1
Show InChI InChI=1S/C10H11N5O2S/c11-10-13-6-5-9(15-10)14-7-1-3-8(4-2-7)18(12,16)17/h1-6H,(H2,12,16,17)(H3,11,13,14,15)
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US Patent
n/an/a 2.55E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316080
PNG
(US9616064, Compound 13n)
Show SMILES Nc1nccc(n1)N1CCc2cc(ccc12)S(N)(=O)=O
Show InChI InChI=1S/C12H13N5O2S/c13-12-15-5-3-11(16-12)17-6-4-8-7-9(20(14,18)19)1-2-10(8)17/h1-3,5,7H,4,6H2,(H2,13,15,16)(H2,14,18,19)
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n/an/a 2.58E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316102
PNG
(US9616064, Compound 21h)
Show SMILES Nc1nccc(n1)-n1ccc2c(OCc3ccccc3Cl)cccc12
Show InChI InChI=1S/C19H15ClN4O/c20-15-5-2-1-4-13(15)12-25-17-7-3-6-16-14(17)9-11-24(16)18-8-10-22-19(21)23-18/h1-11H,12H2,(H2,21,22,23)
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n/an/a 2.91E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316069
PNG
(US9616064, Compound 1bg)
Show SMILES Nc1nccc(Nc2ccc(OC(F)F)cc2)n1
Show InChI InChI=1S/C11H10F2N4O/c12-10(13)18-8-3-1-7(2-4-8)16-9-5-6-15-11(14)17-9/h1-6,10H,(H3,14,15,16,17)
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n/an/a 3.00E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316068
PNG
(US9616064, Compound 1be)
Show SMILES COc1cccc(Nc2ccnc(N)n2)c1
Show InChI InChI=1S/C11H12N4O/c1-16-9-4-2-3-8(7-9)14-10-5-6-13-11(12)15-10/h2-7H,1H3,(H3,12,13,14,15)
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n/an/a 3.02E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316101
PNG
(US9616064, Compound 21g)
Show SMILES Nc1nccc(n1)-n1ccc2c(OCc3cccc(Cl)c3)cccc12
Show InChI InChI=1S/C19H15ClN4O/c20-14-4-1-3-13(11-14)12-25-17-6-2-5-16-15(17)8-10-24(16)18-7-9-22-19(21)23-18/h1-11H,12H2,(H2,21,22,23)
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n/an/a 3.27E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316058
PNG
(US9616064, Compound 1am)
Show SMILES NC(=O)c1cccc(Nc2ccnc(N)n2)c1
Show InChI InChI=1S/C11H11N5O/c12-10(17)7-2-1-3-8(6-7)15-9-4-5-14-11(13)16-9/h1-6H,(H2,12,17)(H3,13,14,15,16)
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n/an/a 3.33E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316124
PNG
(US9616064, Compound 47)
Show SMILES COc1cccc(CNS(=O)(=O)c2cccc(Nc3ccnc(N)n3)c2)c1
Show InChI InChI=1S/C18H19N5O3S/c1-26-15-6-2-4-13(10-15)12-21-27(24,25)16-7-3-5-14(11-16)22-17-8-9-20-18(19)23-17/h2-11,21H,12H2,1H3,(H3,19,20,22,23)
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n/an/a 3.34E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316101
PNG
(US9616064, Compound 21g)
Show SMILES Nc1nccc(n1)-n1ccc2c(OCc3cccc(Cl)c3)cccc12
Show InChI InChI=1S/C19H15ClN4O/c20-14-4-1-3-13(11-14)12-25-17-6-2-5-16-15(17)8-10-24(16)18-7-9-22-19(21)23-18/h1-11H,12H2,(H2,21,22,23)
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n/an/a 3.46E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316064
PNG
(US9616064, Compound 16)
Show SMILES Nc1nccc(n1)N1CCCc2ccccc12
Show InChI InChI=1S/C13H14N4/c14-13-15-8-7-12(16-13)17-9-3-5-10-4-1-2-6-11(10)17/h1-2,4,6-8H,3,5,9H2,(H2,14,15,16)
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n/an/a 3.53E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316062
PNG
(US9616064, Compound 1av)
Show SMILES COC(=O)c1cccc(Nc2ccnc(N)n2)c1
Show InChI InChI=1S/C12H12N4O2/c1-18-11(17)8-3-2-4-9(7-8)15-10-5-6-14-12(13)16-10/h2-7H,1H3,(H3,13,14,15,16)
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n/an/a 3.70E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316071
PNG
(US9616064, Compound 18)
Show SMILES Nc1nccc(n1)-n1cnc2ccccc12
Show InChI InChI=1S/C11H9N5/c12-11-13-6-5-10(15-11)16-7-14-8-3-1-2-4-9(8)16/h1-7H,(H2,12,13,15)
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n/an/a 3.74E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316075
PNG
(US9616064, Compound 13g)
Show SMILES CS(=O)(=O)c1ccc2N(CCc2c1)c1ccnc(N)n1
Show InChI InChI=1S/C13H14N4O2S/c1-20(18,19)10-2-3-11-9(8-10)5-7-17(11)12-4-6-15-13(14)16-12/h2-4,6,8H,5,7H2,1H3,(H2,14,15,16)
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n/an/a 3.79E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM10873
PNG
(4-[(2-aminopyrimidin-4-yl)amino]benzene-1-sulfonam...)
Show SMILES Nc1nccc(Nc2ccc(cc2)S(N)(=O)=O)n1
Show InChI InChI=1S/C10H11N5O2S/c11-10-13-6-5-9(15-10)14-7-1-3-8(4-2-7)18(12,16)17/h1-6H,(H2,12,16,17)(H3,11,13,14,15)
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US Patent
n/an/a 3.85E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316071
PNG
(US9616064, Compound 18)
Show SMILES Nc1nccc(n1)-n1cnc2ccccc12
Show InChI InChI=1S/C11H9N5/c12-11-13-6-5-10(15-11)16-7-14-8-3-1-2-4-9(8)16/h1-7H,(H2,12,13,15)
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n/an/a 3.87E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316058
PNG
(US9616064, Compound 1am)
Show SMILES NC(=O)c1cccc(Nc2ccnc(N)n2)c1
Show InChI InChI=1S/C11H11N5O/c12-10(17)7-2-1-3-8(6-7)15-9-4-5-14-11(13)16-9/h1-6H,(H2,12,17)(H3,13,14,15,16)
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n/an/a 3.89E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316098
PNG
(US9616064, Compound 21b)
Show SMILES Nc1nccc(n1)-n1ccc2cc(OCc3ccccc3)ccc12
Show InChI InChI=1S/C19H16N4O/c20-19-21-10-8-18(22-19)23-11-9-15-12-16(6-7-17(15)23)24-13-14-4-2-1-3-5-14/h1-12H,13H2,(H2,20,21,22)
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n/an/a 3.90E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316062
PNG
(US9616064, Compound 1av)
Show SMILES COC(=O)c1cccc(Nc2ccnc(N)n2)c1
Show InChI InChI=1S/C12H12N4O2/c1-18-11(17)8-3-2-4-9(7-8)15-10-5-6-14-12(13)16-10/h2-7H,1H3,(H3,13,14,15,16)
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n/an/a 3.96E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316121
PNG
(US9616064, Compound 30u)
Show SMILES CN(C(C)=O)c1cccc(CNC(=O)c2cccc3n(ccc23)-c2ccnc(N)n2)c1
Show InChI InChI=1S/C23H22N6O2/c1-15(30)28(2)17-6-3-5-16(13-17)14-26-22(31)19-7-4-8-20-18(19)10-12-29(20)21-9-11-25-23(24)27-21/h3-13H,14H2,1-2H3,(H,26,31)(H2,24,25,27)
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n/an/a 4.03E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316075
PNG
(US9616064, Compound 13g)
Show SMILES CS(=O)(=O)c1ccc2N(CCc2c1)c1ccnc(N)n1
Show InChI InChI=1S/C13H14N4O2S/c1-20(18,19)10-2-3-11-9(8-10)5-7-17(11)12-4-6-15-13(14)16-12/h2-4,6,8H,5,7H2,1H3,(H2,14,15,16)
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n/an/a 4.10E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM316068
PNG
(US9616064, Compound 1be)
Show SMILES COc1cccc(Nc2ccnc(N)n2)c1
Show InChI InChI=1S/C11H12N4O/c1-16-9-4-2-3-8(7-9)14-10-5-6-13-11(12)15-10/h2-7H,1H3,(H3,12,13,14,15)
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n/an/a 4.25E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM314084
PNG
(US9616064, Compound 8)
Show SMILES NS(=O)(=O)c1ccc(Nc2ncnc3nc[nH]c23)cc1
Show InChI InChI=1S/C11H10N6O2S/c12-20(18,19)8-3-1-7(2-4-8)17-11-9-10(14-5-13-9)15-6-16-11/h1-6H,(H2,12,18,19)(H2,13,14,15,16,17)
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n/an/a 4.27E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM313203
PNG
(US9616064, Compound 1af)
Show SMILES Nc1nccc(Nc2ccccc2)n1
Show InChI InChI=1S/C10H10N4/c11-10-12-7-6-9(14-10)13-8-4-2-1-3-5-8/h1-7H,(H3,11,12,13,14)
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n/an/a>5.00E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent




US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316099
PNG
(US9616064, Compound 21c)
Show SMILES Nc1nccc(n1)-n1ccc2c(OCCc3ccccc3)cccc12
Show InChI InChI=1S/C20H18N4O/c21-20-22-12-9-19(23-20)24-13-10-16-17(24)7-4-8-18(16)25-14-11-15-5-2-1-3-6-15/h1-10,12-13H,11,14H2,(H2,21,22,23)
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n/an/a 5.36E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM316094
PNG
(US9616064, Compound 27c)
Show SMILES Nc1nccc(n1)-n1ccc2cc(NC(=O)CCc3ccccc3)ccc12
Show InChI InChI=1S/C21H19N5O/c22-21-23-12-10-19(25-21)26-13-11-16-14-17(7-8-18(16)26)24-20(27)9-6-15-4-2-1-3-5-15/h1-5,7-8,10-14H,6,9H2,(H,24,27)(H2,22,23,25)
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n/an/a 5.41E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM313203
PNG
(US9616064, Compound 1af)
Show SMILES Nc1nccc(Nc2ccccc2)n1
Show InChI InChI=1S/C10H10N4/c11-10-12-7-6-9(14-10)13-8-4-2-1-3-5-8/h1-7H,(H3,11,12,13,14)
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n/an/a 5.53E+4n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM314085
PNG
(US9616064, Compound 1al)
Show SMILES Nc1nccc(Nc2ccc(cc2)S(=O)(=O)Nc2ccccc2)n1
Show InChI InChI=1S/C16H15N5O2S/c17-16-18-11-10-15(20-16)19-12-6-8-14(9-7-12)24(22,23)21-13-4-2-1-3-5-13/h1-11,21H,(H3,17,18,19,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

US Patent


Assay Description
The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...


US Patent US9616064 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%