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Found 34 Enz. Inhib. hit(s) with all data for entry = 1319
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316841(US9617260, Compound 2 | benzyl N-[3- [3-(prop-2- e...)
Affinity DataIC50:  0.300nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316842(US9617260, Compound 3 | propan-2-yl N- [3-[3-(prop...)
Affinity DataIC50:  0.300nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316875(US9617260, Compound 33 | benzyl N-[3- (1-prop-2- e...)
Affinity DataIC50:  0.600nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316873(US9617260, Compound 31 | benzyl N-[3- (1-prop-2- e...)
Affinity DataIC50:  0.600nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316872(US9617260, Compound 30 | benzyl N-[3- (1-prop-2- e...)
Affinity DataIC50:  1.20nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316876(US9617260, Compound 34 | benzyl N-[3- (3-hydroxy-1...)
Affinity DataIC50:  3.60nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316517(US9617260, Compound 1 | benzyl N-[3- [3-[[(E)-4- (...)
Affinity DataIC50:  7nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316843(US9617260, Compound 4 | benzyl N-[3- [3-(2- oxobut...)
Affinity DataIC50:  8nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316844(US9617260, Compound 5 | propan-2-yl N- [3-[3-[[(E)...)
Affinity DataIC50:  13nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316845(US9617260, Compound 6 | propan-2-yl N- [3-[3- [met...)
Affinity DataIC50:  24nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316874(US9617260, Compound 32 | propan-2-yl N- [3-(1-prop...)
Affinity DataIC50:  27nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316855((2- chlorophenyl) methyl N-[3- [3-(2- oxopropanoyl...)
Affinity DataIC50:  30nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316857((3- fluorophenyl) methyl N-[3- [3-(2- oxobutanoyla...)
Affinity DataIC50:  42nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316858((3- fluorophenyl) methyl N-[3- [3-(2- oxopropanoyl...)
Affinity DataIC50:  43.7nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316847(US9617260, Compound 8 | propan-2-yl N- [3-[3-(2- o...)
Affinity DataIC50:  49nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316856((2- chlorophenyl) methyl N-[3- [3-(2- oxobutanoyla...)
Affinity DataIC50:  60nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316850(US9617260, Compound 9 | benzyl N-[3- [3-[2- (trifl...)
Affinity DataIC50:  72nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316851(US9617260, Compound 10 | benzyl N-[3- [3-[(3,3- di...)
Affinity DataIC50:  100nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316860((3- cyanophenyl) methyl N-[3-[3- (2- oxobutanoylam...)
Affinity DataIC50:  114nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316859((3- fluorophenyl) methyl N-[3- [3-[2- (trifluorome...)
Affinity DataIC50:  123nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316861((3- cyanophenyl) methyl N-[3-[3- (2- oxopropanoyla...)
Affinity DataIC50:  137nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316865((2- chlorophenyl) methyl N-[3- [1-(2- oxopropanoyl...)
Affinity DataIC50:  165nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316852(US9617260, Compound 11 | benzyl N-[3- [3-[(3-methy...)
Affinity DataIC50:  206nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316870((3- fluorophenyl) methyl N-[3- [1-(2- oxopropanoyl...)
Affinity DataIC50:  210nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316853(US9617260, Compound 12 | benzyl N-[3- [3-[(4-methy...)
Affinity DataIC50:  285nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316862(US9617260, Compound 21 | benzyl N-[3- [3-[(1- cyan...)
Affinity DataIC50:  287nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316868(US9617260, Compound 27 | benzyl N-[3- [1-(2- oxobu...)
Affinity DataIC50:  291nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316854(US9617260, Compound 13 | benzyl N-[3- [3-[(2-oxo-2...)
Affinity DataIC50:  323nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316864(US9617260, Compound 23 | benzyl N-[3- [2-[[(E)-4- ...)
Affinity DataIC50:  331nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316867((3- fluorophenyl) methyl N-[3- [1-(2- oxobutanoyl)...)
Affinity DataIC50:  384nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316866((2- chlorophenyl) methyl N-[3- [1-(2- oxobutanoyl)...)
Affinity DataIC50:  404nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316863(US9617260, Compound 22 | propan-2-yl N- [3-[3-[(2-...)
Affinity DataIC50:  620nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316871((3- cyanophenyl) methyl N-[3-[1- (2- oxopropanoyl)...)
Affinity DataIC50:  700nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM316846(US9617260, Compound 7 | propan-2-yl N- [3-[3-[3- m...)
Affinity DataIC50:  880nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluoresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent