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Patent code US9617261

Compile Data Set for Download or QSAR
Found 11 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (human))
BDBM316884
PNG
(US9617261, Example 00085)
Show SMILES Cn1c(Nc2ccc(I)cc2F)c(C(=O)NOCC(O)CO)c2CCCc2c1=O
Show InChI InChI=1S/C19H21FIN3O5/c1-24-17(22-15-6-5-10(21)7-14(15)20)16(12-3-2-4-13(12)19(24)28)18(27)23-29-9-11(26)8-25/h5-7,11,22,25-26H,2-4,8-9H2,1H3,(H,23,27)
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n/an/a<500n/an/an/an/an/an/a



CMG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The LANCE Ultra assay kit was purchased from PerkinElmer. The ULight-MBP peptide, Europium labeled Antibody and LANCE Detection buffer were purchased...


US Patent US9617261 (2017)

More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (human))
BDBM316879
PNG
(US9617261, Example 00080)
Show SMILES Cn1c(Nc2ccc(I)cc2F)c(C(=O)NOCCO)c2CCCc2c1=O
Show InChI InChI=1S/C18H19FIN3O4/c1-23-16(21-14-6-5-10(20)9-13(14)19)15(17(25)22-27-8-7-24)11-3-2-4-12(11)18(23)26/h5-6,9,21,24H,2-4,7-8H2,1H3,(H,22,25)
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n/an/a<500n/an/an/an/an/an/a



CMG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The LANCE Ultra assay kit was purchased from PerkinElmer. The ULight-MBP peptide, Europium labeled Antibody and LANCE Detection buffer were purchased...


US Patent US9617261 (2017)

More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (human))
BDBM316881
PNG
(US9617261, Example 00082)
Show SMILES C[C@H](O)CONC(=O)c1c2CCCc2c(=O)n(C)c1Nc1ccc(I)cc1F
Show InChI InChI=1S/C19H21FIN3O4/c1-10(25)9-28-23-18(26)16-12-4-3-5-13(12)19(27)24(2)17(16)22-15-7-6-11(21)8-14(15)20/h6-8,10,22,25H,3-5,9H2,1-2H3,(H,23,26)/t10-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



CMG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The LANCE Ultra assay kit was purchased from PerkinElmer. The ULight-MBP peptide, Europium labeled Antibody and LANCE Detection buffer were purchased...


US Patent US9617261 (2017)

More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (human))
BDBM316886
PNG
(US9617261, Example 00087)
Show SMILES Cn1c(Nc2ccc(I)cc2F)c(C(=O)NOCCO)c2CC(C)(C)Cc2c1=O
Show InChI InChI=1S/C20H23FIN3O4/c1-20(2)9-12-13(10-20)19(28)25(3)17(16(12)18(27)24-29-7-6-26)23-15-5-4-11(22)8-14(15)21/h4-5,8,23,26H,6-7,9-10H2,1-3H3,(H,24,27)
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n/an/a<500n/an/an/an/an/an/a



CMG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The LANCE Ultra assay kit was purchased from PerkinElmer. The ULight-MBP peptide, Europium labeled Antibody and LANCE Detection buffer were purchased...


US Patent US9617261 (2017)

More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (human))
BDBM316887
PNG
(US9617261, Example 00088)
Show SMILES Cn1c(Nc2ccc(I)cc2Cl)c(C(=O)NOCCO)c2CCCc2c1=O
Show InChI InChI=1S/C18H19ClIN3O4/c1-23-16(21-14-6-5-10(20)9-13(14)19)15(17(25)22-27-8-7-24)11-3-2-4-12(11)18(23)26/h5-6,9,21,24H,2-4,7-8H2,1H3,(H,22,25)
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n/an/a<500n/an/an/an/an/an/a



CMG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The LANCE Ultra assay kit was purchased from PerkinElmer. The ULight-MBP peptide, Europium labeled Antibody and LANCE Detection buffer were purchased...


US Patent US9617261 (2017)

More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (human))
BDBM316882
PNG
(US9617261, Example 00083)
Show SMILES [*].C[C@@H](O)CONC(=O)c1c2CCCc2c(=O)n(C)c1Nc1ccc(I)cc1F
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n/an/a<1.00E+3n/an/an/an/an/an/a



CMG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The LANCE Ultra assay kit was purchased from PerkinElmer. The ULight-MBP peptide, Europium labeled Antibody and LANCE Detection buffer were purchased...


US Patent US9617261 (2017)

More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (human))
BDBM316877
PNG
(US9617261, Example 00078)
Show SMILES Cn1c(Nc2ccc(I)cc2F)c(C(=O)NOCCO)c2ncccc2c1=O
Show InChI InChI=1S/C18H16FIN4O4/c1-24-16(22-13-5-4-10(20)9-12(13)19)14(17(26)23-28-8-7-25)15-11(18(24)27)3-2-6-21-15/h2-6,9,22,25H,7-8H2,1H3,(H,23,26)
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n/an/a<1.00E+3n/an/an/an/an/an/a



CMG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The LANCE Ultra assay kit was purchased from PerkinElmer. The ULight-MBP peptide, Europium labeled Antibody and LANCE Detection buffer were purchased...


US Patent US9617261 (2017)

More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (human))
BDBM316880
PNG
(US9617261, Example 00081)
Show SMILES Cn1c(Nc2ccc(I)cc2F)c(C(N)=O)c2CCCc2c1=O
Show InChI InChI=1S/C16H15FIN3O2/c1-21-15(20-12-6-5-8(18)7-11(12)17)13(14(19)22)9-3-2-4-10(9)16(21)23/h5-7,20H,2-4H2,1H3,(H2,19,22)
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n/an/a<5.00E+3n/an/an/an/an/an/a



CMG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The LANCE Ultra assay kit was purchased from PerkinElmer. The ULight-MBP peptide, Europium labeled Antibody and LANCE Detection buffer were purchased...


US Patent US9617261 (2017)

More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (human))
BDBM316883
PNG
(US9617261, Example 00084)
Show SMILES Cn1c(Nc2ccc(I)cc2F)c(C(=O)NOCC(C)(C)O)c2CCCc2c1=O
Show InChI InChI=1S/C20H23FIN3O4/c1-20(2,28)10-29-24-18(26)16-12-5-4-6-13(12)19(27)25(3)17(16)23-15-8-7-11(22)9-14(15)21/h7-9,23,28H,4-6,10H2,1-3H3,(H,24,26)
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CMG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The LANCE Ultra assay kit was purchased from PerkinElmer. The ULight-MBP peptide, Europium labeled Antibody and LANCE Detection buffer were purchased...


US Patent US9617261 (2017)

More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (human))
BDBM316885
PNG
(US9617261, Example 00086)
Show SMILES Cn1c(Nc2ccc(I)cc2F)c(c2CCCc2c1=O)-c1nnc(N)o1
Show InChI InChI=1S/C17H15FIN5O2/c1-24-14(21-12-6-5-8(19)7-11(12)18)13(15-22-23-17(20)26-15)9-3-2-4-10(9)16(24)25/h5-7,21H,2-4H2,1H3,(H2,20,23)
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CMG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The LANCE Ultra assay kit was purchased from PerkinElmer. The ULight-MBP peptide, Europium labeled Antibody and LANCE Detection buffer were purchased...


US Patent US9617261 (2017)

More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (human))
BDBM316878
PNG
(US9617261, Example 00079)
Show SMILES Cn1c(Nc2ccc(I)cc2F)c(-c2nnc(N)o2)c2ncccc2c1=O
Show InChI InChI=1S/C17H12FIN6O2/c1-25-14(22-11-5-4-8(19)7-10(11)18)12(15-23-24-17(20)27-15)13-9(16(25)26)3-2-6-21-13/h2-7,22H,1H3,(H2,20,24)
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CMG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The LANCE Ultra assay kit was purchased from PerkinElmer. The ULight-MBP peptide, Europium labeled Antibody and LANCE Detection buffer were purchased...


US Patent US9617261 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%