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Patent code US9617282

Compile Data Set for Download or QSAR

Found 218 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317361
PNG
(US9617282, Example 134)
Show SMILES O=C1Nc2cn(nc2C(=O)NCCOCCc2cc(ccn2)-c2nc1cs2)C1CCOCC1
Show InChI InChI=1S/C22H24N6O4S/c29-20-18-13-33-22(26-18)14-1-5-23-15(11-14)2-7-32-10-6-24-21(30)19-17(25-20)12-28(27-19)16-3-8-31-9-4-16/h1,5,11-13,16H,2-4,6-10H2,(H,24,30)(H,25,29)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317380
PNG
(US9617282, Example 153)
Show SMILES CN1CCC(CCn2cc3NC(=O)c4csc(n4)-c4ccnc(OCCOCCNC(=O)c3n2)c4)CC1
Show InChI InChI=1S/C25H31N7O4S/c1-31-8-3-17(4-9-31)5-10-32-15-19-22(30-32)24(34)27-7-11-35-12-13-36-21-14-18(2-6-26-21)25-29-20(16-37-25)23(33)28-19/h2,6,14-17H,3-5,7-13H2,1H3,(H,27,34)(H,28,33)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317388
PNG
(US9617282, Example 161)
Show SMILES CNC(=O)Cn1cc2NC(=O)c3csc(n3)-c3ccnc(OCCOCCNC(=O)c2n1)c3
Show InChI InChI=1S/C20H21N7O5S/c1-21-15(28)10-27-9-13-17(26-27)19(30)23-4-5-31-6-7-32-16-8-12(2-3-22-16)20-25-14(11-33-20)18(29)24-13/h2-3,8-9,11H,4-7,10H2,1H3,(H,21,28)(H,23,30)(H,24,29)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317413
PNG
(US9617282, Example 188)
Show SMILES OCCC(=O)N1CCCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc2C(=O)NCC1)C1CCOCC1
Show InChI InChI=1S/C26H31N7O5S/c34-11-4-22(35)32-9-1-2-18-14-17(3-7-27-18)26-30-21(16-39-26)24(36)29-20-15-33(19-5-12-38-13-6-19)31-23(20)25(37)28-8-10-32/h3,7,14-16,19,34H,1-2,4-6,8-13H2,(H,28,37)(H,29,36)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317416
PNG
(US9617282, Example 191)
Show SMILES CCNC(=O)N1CCCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc2C(=O)NCC1)C1CCOCC1
Show InChI InChI=1S/C26H32N8O4S/c1-2-27-26(37)33-10-3-4-18-14-17(5-8-28-18)25-31-21(16-39-25)23(35)30-20-15-34(19-6-12-38-13-7-19)32-22(20)24(36)29-9-11-33/h5,8,14-16,19H,2-4,6-7,9-13H2,1H3,(H,27,37)(H,29,36)(H,30,35)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317428
PNG
(US9617282, Example 203)
Show SMILES Cn1cc2NC(=O)c3cccc(n3)-c3ccnc(OCCOCCNC(=O)c2n1)c3
Show InChI InChI=1S/C20H20N6O4/c1-26-12-16-18(25-26)20(28)22-7-8-29-9-10-30-17-11-13(5-6-21-17)14-3-2-4-15(23-14)19(27)24-16/h2-6,11-12H,7-10H2,1H3,(H,22,28)(H,24,27)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317432
PNG
(US9617282, Example 207)
Show SMILES Cn1cc2NC(=O)c3csc(c3)-c3ccnc(OCCOCCNC(=O)c2n1)c3
Show InChI InChI=1S/C19H19N5O4S/c1-24-10-14-17(23-24)19(26)21-4-5-27-6-7-28-16-9-12(2-3-20-16)15-8-13(11-29-15)18(25)22-14/h2-3,8-11H,4-7H2,1H3,(H,21,26)(H,22,25)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317260
PNG
(US9617282, Example 29)
Show SMILES Cn1cc2NC(=O)c3coc(n3)-c3ccnc(NCCCCCCCCNC(=O)c2n1)c3
Show InChI InChI=1S/C22H27N7O3/c1-29-13-16-19(28-29)21(31)25-10-7-5-3-2-4-6-9-23-18-12-15(8-11-24-18)22-27-17(14-32-22)20(30)26-16/h8,11-14H,2-7,9-10H2,1H3,(H,23,24)(H,25,31)(H,26,30)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317278
PNG
(US9617282, Example 48)
Show SMILES Cn1cc2NC(=O)c3csc(n3)-c3ccnc(CCCOCCNC(=O)c2n1)c3
Show InChI InChI=1S/C19H20N6O3S/c1-25-10-14-16(24-25)18(27)21-6-8-28-7-2-3-13-9-12(4-5-20-13)19-23-15(11-29-19)17(26)22-14/h4-5,9-11H,2-3,6-8H2,1H3,(H,21,27)(H,22,26)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317334
PNG
(US9617282, Example 107)
Show SMILES O=C1Nc2c[nH]nc2C(=O)NCCOCCOc2cc(ccn2)-c2nc1cs2
Show InChI InChI=1S/C17H16N6O4S/c24-15-12-9-28-17(22-12)10-1-2-18-13(7-10)27-6-5-26-4-3-19-16(25)14-11(21-15)8-20-23-14/h1-2,7-9H,3-6H2,(H,19,25)(H,20,23)(H,21,24)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317372
PNG
(US9617282, Example 145)
Show SMILES O=C1Nc2cn(CCN3CCNCC3)nc2C(=O)NCCOCCNc2cc(ccn2)-c2nc1cs2
Show InChI InChI=1S/C23H29N9O3S/c33-21-18-15-36-23(29-18)16-1-2-25-19(13-16)26-5-11-35-12-6-27-22(34)20-17(28-21)14-32(30-20)10-9-31-7-3-24-4-8-31/h1-2,13-15,24H,3-12H2,(H,25,26)(H,27,34)(H,28,33)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317397
PNG
(US9617282, Example 170)
Show SMILES CC(=O)N1CCCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc2C(=O)NCC1)C1CCOCC1
Show InChI InChI=1S/C25H29N7O4S/c1-16(33)31-9-2-3-18-13-17(4-7-26-18)25-29-21(15-37-25)23(34)28-20-14-32(19-5-11-36-12-6-19)30-22(20)24(35)27-8-10-31/h4,7,13-15,19H,2-3,5-6,8-12H2,1H3,(H,27,35)(H,28,34)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317406
PNG
(US9617282, Example 181)
Show SMILES NC(=O)CCN1CCCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc2C(=O)NCC1)C1CCOCC1
Show InChI InChI=1S/C26H32N8O4S/c27-22(35)4-10-33-9-1-2-18-14-17(3-7-28-18)26-31-21(16-39-26)24(36)30-20-15-34(19-5-12-38-13-6-19)32-23(20)25(37)29-8-11-33/h3,7,14-16,19H,1-2,4-6,8-13H2,(H2,27,35)(H,29,37)(H,30,36)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317411
PNG
(US9617282, Example 186)
Show SMILES CNC(=O)N1CCCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc2C(=O)NCC1)C1CCOCC1
Show InChI InChI=1S/C25H30N8O4S/c1-26-25(36)32-9-2-3-17-13-16(4-7-27-17)24-30-20(15-38-24)22(34)29-19-14-33(18-5-11-37-12-6-18)31-21(19)23(35)28-8-10-32/h4,7,13-15,18H,2-3,5-6,8-12H2,1H3,(H,26,36)(H,28,35)(H,29,34)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317442
PNG
(US9617282, Example 218)
Show SMILES O=C1NCCOCCCCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc12)C1CCOCC1
Show InChI InChI=1S/C24H28N6O4S/c31-22-20-15-35-24(28-20)16-4-7-25-17(13-16)3-1-2-9-33-12-8-26-23(32)21-19(27-22)14-30(29-21)18-5-10-34-11-6-18/h4,7,13-15,18H,1-3,5-6,8-12H2,(H,26,32)(H,27,31)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317445
PNG
(US9617282, Example 221)
Show SMILES CN1CCOCCNC(=O)c2nn(CCN3CCCCC3)cc2NC(=O)c2csc(n2)-c2ccnc1c2
Show InChI InChI=1S/C25H32N8O3S/c1-31-12-14-36-13-7-27-24(35)22-19(16-33(30-22)11-10-32-8-3-2-4-9-32)28-23(34)20-17-37-25(29-20)18-5-6-26-21(31)15-18/h5-6,15-17H,2-4,7-14H2,1H3,(H,27,35)(H,28,34)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317233
PNG
(US9617282, Example 2)
Show SMILES O=C1Nc2ccccc2OCCCCCNc2cc(ccn2)-c2nc1co2
Show InChI InChI=1S/C20H20N4O3/c25-19-16-13-27-20(24-16)14-8-10-22-18(12-14)21-9-4-1-5-11-26-17-7-3-2-6-15(17)23-19/h2-3,6-8,10,12-13H,1,4-5,9,11H2,(H,21,22)(H,23,25)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317247
PNG
(US9617282, Example 16)
Show SMILES CN(C)CCNC(=O)c1ccc2OCCCCCNc3cc(ccn3)-c3nc(cs3)C(=O)Nc2c1
Show InChI InChI=1S/C25H30N6O3S/c1-31(2)12-11-28-23(32)17-6-7-21-19(14-17)29-24(33)20-16-35-25(30-20)18-8-10-27-22(15-18)26-9-4-3-5-13-34-21/h6-8,10,14-16H,3-5,9,11-13H2,1-2H3,(H,26,27)(H,28,32)(H,29,33)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317249
PNG
(US9617282, Example 18)
Show SMILES O=C(NCCN1CCCCC1)c1ccc2OCCCCCNc3cc(ccn3)-c3nc(cs3)C(=O)Nc2c1
Show InChI InChI=1S/C28H34N6O3S/c35-26(31-12-15-34-13-4-2-5-14-34)20-7-8-24-22(17-20)32-27(36)23-19-38-28(33-23)21-9-11-30-25(18-21)29-10-3-1-6-16-37-24/h7-9,11,17-19H,1-6,10,12-16H2,(H,29,30)(H,31,35)(H,32,36)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317255
PNG
(US9617282, Example 24)
Show SMILES NC(=O)c1ccc2OCCCCCNc3cc(ccn3)-c3nc(cs3)C(=O)Nc2c1
Show InChI InChI=1S/C21H21N5O3S/c22-19(27)13-4-5-17-15(10-13)25-20(28)16-12-30-21(26-16)14-6-8-24-18(11-14)23-7-2-1-3-9-29-17/h4-6,8,10-12H,1-3,7,9H2,(H2,22,27)(H,23,24)(H,25,28)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317256
PNG
(US9617282, Example 25)
Show SMILES CN(C)CCNC(=O)c1ccc2NC(=O)c3csc(n3)-c3ccnc(NCCCCCOc2c1)c3
Show InChI InChI=1S/C25H30N6O3S/c1-31(2)12-11-28-23(32)17-6-7-19-21(14-17)34-13-5-3-4-9-26-22-15-18(8-10-27-22)25-30-20(16-35-25)24(33)29-19/h6-8,10,14-16H,3-5,9,11-13H2,1-2H3,(H,26,27)(H,28,32)(H,29,33)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317261
PNG
(US9617282, Example 31)
Show SMILES Cn1cc2NC(=O)c3coc(n3)-c3ccnc(NCCCCNC(=O)c2n1)c3
Show InChI InChI=1S/C18H19N7O3/c1-25-9-12-15(24-25)17(27)21-6-3-2-5-19-14-8-11(4-7-20-14)18-23-13(10-28-18)16(26)22-12/h4,7-10H,2-3,5-6H2,1H3,(H,19,20)(H,21,27)(H,22,26)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317265
PNG
(US9617282, Example 35)
Show SMILES Cn1cc2NC(=O)c3coc(n3)-c3ccnc(OCCOCCNC(=O)c2n1)c3
Show InChI InChI=1S/C18H18N6O5/c1-24-9-12-15(23-24)17(26)20-4-5-27-6-7-28-14-8-11(2-3-19-14)18-22-13(10-29-18)16(25)21-12/h2-3,8-10H,4-7H2,1H3,(H,20,26)(H,21,25)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317269
PNG
(US9617282, Example 39)
Show SMILES Cn1cc2NC(=O)c3coc(n3)-c3ccnc(CCCCCNC(=O)c2n1)c3
Show InChI InChI=1S/C19H20N6O3/c1-25-10-14-16(24-25)18(27)21-7-4-2-3-5-13-9-12(6-8-20-13)19-23-15(11-28-19)17(26)22-14/h6,8-11H,2-5,7H2,1H3,(H,21,27)(H,22,26)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317270
PNG
(US9617282, Example 40)
Show SMILES O=C1Nc2cn(nc2C(=O)NCCCCCc2cc(ccn2)-c2nc1co2)C1CCOCC1
Show InChI InChI=1S/C23H26N6O4/c30-21-19-14-33-23(27-19)15-5-9-24-16(12-15)4-2-1-3-8-25-22(31)20-18(26-21)13-29(28-20)17-6-10-32-11-7-17/h5,9,12-14,17H,1-4,6-8,10-11H2,(H,25,31)(H,26,30)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317275
PNG
(US9617282, Example 45)
Show SMILES Cn1cc2NC(=O)c3csc(n3)-c3ccnc(NCCOCCNC(=O)c2n1)c3
Show InChI InChI=1S/C18H19N7O3S/c1-25-9-12-15(24-25)17(27)21-5-7-28-6-4-20-14-8-11(2-3-19-14)18-23-13(10-29-18)16(26)22-12/h2-3,8-10H,4-7H2,1H3,(H,19,20)(H,21,27)(H,22,26)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317299
PNG
(US9617282, Example 69)
Show SMILES CC1CCCCNc2cc(ccn2)-c2nc(co2)C(=O)Nc2ccccc2O1
Show InChI InChI=1S/C21H22N4O3/c1-14-6-4-5-10-22-19-12-15(9-11-23-19)21-25-17(13-27-21)20(26)24-16-7-2-3-8-18(16)28-14/h2-3,7-9,11-14H,4-6,10H2,1H3,(H,22,23)(H,24,26)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317312
PNG
(US9617282, Example 83)
Show SMILES O=C1NC[C@@H]2CC[C@@H](C2)OCCCNc2cc(ccn2)-c2nc1cs2
Show InChI InChI=1S/C18H22N4O2S/c23-17-15-11-25-18(22-15)13-4-6-20-16(9-13)19-5-1-7-24-14-3-2-12(8-14)10-21-17/h4,6,9,11-12,14H,1-3,5,7-8,10H2,(H,19,20)(H,21,23)/t12-,14+/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317339
PNG
(US9617282, Example 112)
Show SMILES O=C1NCCOCCOc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(CCN3CCOCC3)nc12
Show InChI InChI=1S/C23H27N7O5S/c31-21-18-15-36-23(27-18)16-1-2-24-19(13-16)35-12-11-33-8-3-25-22(32)20-17(26-21)14-30(28-20)5-4-29-6-9-34-10-7-29/h1-2,13-15H,3-12H2,(H,25,32)(H,26,31)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317340
PNG
(US9617282, Example 113)
Show SMILES CN1CCN(CCn2cc3NC(=O)c4csc(n4)-c4ccnc(OCCOCCNC(=O)c3n2)c4)CC1
Show InChI InChI=1S/C24H30N8O4S/c1-30-5-7-31(8-6-30)9-10-32-15-18-21(29-32)23(34)26-4-11-35-12-13-36-20-14-17(2-3-25-20)24-28-19(16-37-24)22(33)27-18/h2-3,14-16H,4-13H2,1H3,(H,26,34)(H,27,33)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317349
PNG
(US9617282, Example 122)
Show SMILES Cn1cc2NC(=O)c3csc(n3)-c3ccnc(OCCCOCCNC(=O)c2n1)c3
Show InChI InChI=1S/C19H20N6O4S/c1-25-10-13-16(24-25)18(27)21-5-8-28-6-2-7-29-15-9-12(3-4-20-15)19-23-14(11-30-19)17(26)22-13/h3-4,9-11H,2,5-8H2,1H3,(H,21,27)(H,22,26)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317357
PNG
(US9617282, Example 130)
Show SMILES O=C1Nc2cnccc2C(=O)NCCOCCOc2cc(ccn2)-c2nc1cs2
Show InChI InChI=1S/C19H17N5O4S/c25-17-13-2-3-20-10-14(13)23-18(26)15-11-29-19(24-15)12-1-4-21-16(9-12)28-8-7-27-6-5-22-17/h1-4,9-11H,5-8H2,(H,22,25)(H,23,26)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317363
PNG
(US9617282, Example 136)
Show SMILES O=C1NCCOCCCn2cc(cn2)-c2nc(cs2)C(=O)Nc2cn(nc12)C1CCOCC1
Show InChI InChI=1S/C21H25N7O4S/c29-19-17-13-33-21(25-17)14-10-23-27(11-14)5-1-6-31-9-4-22-20(30)18-16(24-19)12-28(26-18)15-2-7-32-8-3-15/h10-13,15H,1-9H2,(H,22,30)(H,24,29)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317366
PNG
(US9617282, Example 139)
Show SMILES CCn1cc2NC(=O)c3csc(n3)-c3ccnc(OCCOCCNC(=O)c2n1)c3
Show InChI InChI=1S/C19H20N6O4S/c1-2-25-10-13-16(24-25)18(27)21-5-6-28-7-8-29-15-9-12(3-4-20-15)19-23-14(11-30-19)17(26)22-13/h3-4,9-11H,2,5-8H2,1H3,(H,21,27)(H,22,26)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317367
PNG
(US9617282, Example 140)
Show SMILES Cn1cc2NC(=O)c3coc(n3)-c3ccnc(NCCC\C=C\CCCNC(=O)c2n1)c3
Show InChI InChI=1S/C22H25N7O3/c1-29-13-16-19(28-29)21(31)25-10-7-5-3-2-4-6-9-23-18-12-15(8-11-24-18)22-27-17(14-32-22)20(30)26-16/h2-3,8,11-14H,4-7,9-10H2,1H3,(H,23,24)(H,25,31)(H,26,30)/b3-2+
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317404
PNG
(US9617282, Example 179)
Show SMILES OC(=O)CCN1CCCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc2C(=O)NCC1)C1CCOCC1
Show InChI InChI=1S/C26H31N7O5S/c34-22(35)4-10-32-9-1-2-18-14-17(3-7-27-18)26-30-21(16-39-26)24(36)29-20-15-33(19-5-12-38-13-6-19)31-23(20)25(37)28-8-11-32/h3,7,14-16,19H,1-2,4-6,8-13H2,(H,28,37)(H,29,36)(H,34,35)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317449
PNG
(US9617282, Example 225)
Show SMILES O=C1CCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc2C(=O)NCCN1)C1CCOCC1
Show InChI InChI=1S/C23H25N7O4S/c31-19-2-1-15-11-14(3-6-24-15)23-28-18(13-35-23)21(32)27-17-12-30(16-4-9-34-10-5-16)29-20(17)22(33)26-8-7-25-19/h3,6,11-13,16H,1-2,4-5,7-10H2,(H,25,31)(H,26,33)(H,27,32)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317232
PNG
(US9617282, Example 1)
Show SMILES O=C1Nc2ccccc2OCC\C=C\COc2cc(ccn2)-c2nc1co2
Show InChI InChI=1S/C20H17N3O4/c24-19-16-13-27-20(23-16)14-8-9-21-18(12-14)26-11-5-1-4-10-25-17-7-3-2-6-15(17)22-19/h1-3,5-9,12-13H,4,10-11H2,(H,22,24)/b5-1+
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317236
PNG
(US9617282, Example 5)
Show SMILES O=C1Nc2ccccc2OCCCCCCc2cc(ccn2)-c2nc1co2
Show InChI InChI=1S/C21H21N3O3/c25-20-18-14-27-21(24-18)15-10-11-22-16(13-15)7-3-1-2-6-12-26-19-9-5-4-8-17(19)23-20/h4-5,8-11,13-14H,1-3,6-7,12H2,(H,23,25)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317239
PNG
(US9617282, Example 8)
Show SMILES O=C1Nc2ccccc2OCCCCCCCn2cc(cn2)-c2nc1co2
Show InChI InChI=1S/C20H22N4O3/c25-19-17-14-27-20(23-17)15-12-21-24(13-15)10-6-2-1-3-7-11-26-18-9-5-4-8-16(18)22-19/h4-5,8-9,12-14H,1-3,6-7,10-11H2,(H,22,25)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317244
PNG
(US9617282, Example 13)
Show SMILES O=C1Nc2ccccc2OCCCCCNc2cc(ccn2)-c2nc1cs2
Show InChI InChI=1S/C20H20N4O2S/c25-19-16-13-27-20(24-16)14-8-10-22-18(12-14)21-9-4-1-5-11-26-17-7-3-2-6-15(17)23-19/h2-3,6-8,10,12-13H,1,4-5,9,11H2,(H,21,22)(H,23,25)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317251
PNG
(US9617282, Example 20)
Show SMILES CN(C)C(=O)c1ccc2OCCCCCNc3cc(ccn3)-c3nc(cs3)C(=O)Nc2c1
Show InChI InChI=1S/C23H25N5O3S/c1-28(2)23(30)16-6-7-19-17(12-16)26-21(29)18-14-32-22(27-18)15-8-10-25-20(13-15)24-9-4-3-5-11-31-19/h6-8,10,12-14H,3-5,9,11H2,1-2H3,(H,24,25)(H,26,29)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317274
PNG
(US9617282, Example 44)
Show SMILES O=C1NCCOCCOc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc12)C1CCOCC1
Show InChI InChI=1S/C22H24N6O5S/c29-20-17-13-34-22(26-17)14-1-4-23-18(11-14)33-10-9-32-8-5-24-21(30)19-16(25-20)12-28(27-19)15-2-6-31-7-3-15/h1,4,11-13,15H,2-3,5-10H2,(H,24,30)(H,25,29)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317276
PNG
(US9617282, Example 46)
Show SMILES O=C1Nc2cn(nc2C(=O)NCCOCCNc2cc(ccn2)-c2nc1cs2)C1CCOCC1
Show InChI InChI=1S/C22H25N7O4S/c30-20-17-13-34-22(27-17)14-1-4-23-18(11-14)24-5-9-33-10-6-25-21(31)19-16(26-20)12-29(28-19)15-2-7-32-8-3-15/h1,4,11-13,15H,2-3,5-10H2,(H,23,24)(H,25,31)(H,26,30)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317302
PNG
(US9617282, Example 72)
Show SMILES O=C1Nc2ccccc2OCCCCCCn2cc(cn2)-c2nc1cs2
Show InChI InChI=1S/C19H20N4O2S/c24-18-16-13-26-19(22-16)14-11-20-23(12-14)9-5-1-2-6-10-25-17-8-4-3-7-15(17)21-18/h3-4,7-8,11-13H,1-2,5-6,9-10H2,(H,21,24)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317303
PNG
(US9617282, Example 73)
Show SMILES Brc1ccc2OCCCCCNc3cc(ccn3)-c3nc(cs3)C(=O)Nc2c1
Show InChI InChI=1S/C20H19BrN4O2S/c21-14-4-5-17-15(11-14)24-19(26)16-12-28-20(25-16)13-6-8-23-18(10-13)22-7-2-1-3-9-27-17/h4-6,8,10-12H,1-3,7,9H2,(H,22,23)(H,24,26)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317352
PNG
(US9617282, Example 125)
Show SMILES O=C1Nc2cn(nc2C(=O)NCCCOCCOc2cc(ccn2)-c2nc1co2)C1CCOCC1
Show InChI InChI=1S/C23H26N6O6/c30-21-18-14-35-23(27-18)15-2-6-24-19(12-15)34-11-10-32-7-1-5-25-22(31)20-17(26-21)13-29(28-20)16-3-8-33-9-4-16/h2,6,12-14,16H,1,3-5,7-11H2,(H,25,31)(H,26,30)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317377
PNG
(US9617282, Example 150)
Show SMILES CCOC(=O)CCn1cc2NC(=O)c3csc(n3)-c3ccnc(OCCOCCNC(=O)c2n1)c3
Show InChI InChI=1S/C22H24N6O6S/c1-2-33-18(29)4-7-28-12-15-19(27-28)21(31)24-6-8-32-9-10-34-17-11-14(3-5-23-17)22-26-16(13-35-22)20(30)25-15/h3,5,11-13H,2,4,6-10H2,1H3,(H,24,31)(H,25,30)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317392
PNG
(US9617282, Example 165)
Show SMILES O=C1Nc2cn(nc2C(=O)NCCOCCOc2cc(ccn2)-c2nc1cs2)C1CCNCC1
Show InChI InChI=1S/C22H25N7O4S/c30-20-17-13-34-22(27-17)14-1-6-24-18(11-14)33-10-9-32-8-7-25-21(31)19-16(26-20)12-29(28-19)15-2-4-23-5-3-15/h1,6,11-13,15,23H,2-5,7-10H2,(H,25,31)(H,26,30)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317399
PNG
(US9617282, Example 174)
Show SMILES CC(C)N1CCCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc2C(=O)NCC1)C1CCOCC1
Show InChI InChI=1S/C26H33N7O3S/c1-17(2)32-10-3-4-19-14-18(5-8-27-19)26-30-22(16-37-26)24(34)29-21-15-33(20-6-12-36-13-7-20)31-23(21)25(35)28-9-11-32/h5,8,14-17,20H,3-4,6-7,9-13H2,1-2H3,(H,28,35)(H,29,34)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%