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Patent code US9624175

Compile Data Set for Download or QSAR
Found 82 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)(R132C)


(Homo sapiens (Human))
BDBM317535
PNG
(6-chloro-7-methoxy-3-[1-({1-methyl-2-oxo-1H,2H,4H-...)
Show SMILES COc1cc2[nH]c(=O)c(cc2cc1Cl)C(C)Nc1ncc2COC(=O)N(C)c2n1
Show InChI InChI=1S/C19H18ClN5O4/c1-9(22-18-21-7-11-8-29-19(27)25(2)16(11)24-18)12-4-10-5-13(20)15(28-3)6-14(10)23-17(12)26/h4-7,9H,8H2,1-3H3,(H,23,26)(H,21,22,24)
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n/an/a<100n/an/an/an/an/an/a



FORMA THERAPEUTICS, INC.

US Patent




US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)(R132C)


(Homo sapiens (Human))
BDBM317533
PNG
(6-chloro-3-[(1S)-1-({1-methyl-2-oxo-1H,2H,4H-pyrim...)
Show SMILES C[C@H](Nc1ncc2COC(=O)N(C)c2n1)c1cc2cc(Cl)c(OCc3ccccn3)cc2[nH]c1=O
Show InChI InChI=1S/C24H21ClN6O4/c1-13(28-23-27-10-15-11-35-24(33)31(2)21(15)30-23)17-7-14-8-18(25)20(9-19(14)29-22(17)32)34-12-16-5-3-4-6-26-16/h3-10,13H,11-12H2,1-2H3,(H,29,32)(H,27,28,30)/t13-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



FORMA THERAPEUTICS, INC.

US Patent




US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)(R132C)


(Homo sapiens (Human))
BDBM317531
PNG
(6-chloro-3-[(1S)-1-{[1-(2-methylpropyl)-2-oxo-1H,2...)
Show SMILES CC(C)CN1C(=O)OCc2cnc(N[C@@H](C)c3cc4cc(Cl)ccc4[nH]c3=O)nc12
Show InChI InChI=1S/C21H22ClN5O3/c1-11(2)9-27-18-14(10-30-21(27)29)8-23-20(26-18)24-12(3)16-7-13-6-15(22)4-5-17(13)25-19(16)28/h4-8,11-12H,9-10H2,1-3H3,(H,25,28)(H,23,24,26)/t12-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



FORMA THERAPEUTICS, INC.

US Patent




US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317533
PNG
(6-chloro-3-[(1S)-1-({1-methyl-2-oxo-1H,2H,4H-pyrim...)
Show SMILES C[C@H](Nc1ncc2COC(=O)N(C)c2n1)c1cc2cc(Cl)c(OCc3ccccn3)cc2[nH]c1=O
Show InChI InChI=1S/C24H21ClN6O4/c1-13(28-23-27-10-15-11-35-24(33)31(2)21(15)30-23)17-7-14-8-18(25)20(9-19(14)29-22(17)32)34-12-16-5-3-4-6-26-16/h3-10,13H,11-12H2,1-2H3,(H,29,32)(H,27,28,30)/t13-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317531
PNG
(6-chloro-3-[(1S)-1-{[1-(2-methylpropyl)-2-oxo-1H,2...)
Show SMILES CC(C)CN1C(=O)OCc2cnc(N[C@@H](C)c3cc4cc(Cl)ccc4[nH]c3=O)nc12
Show InChI InChI=1S/C21H22ClN5O3/c1-11(2)9-27-18-14(10-30-21(27)29)8-23-20(26-18)24-12(3)16-7-13-6-15(22)4-5-17(13)25-19(16)28/h4-8,11-12H,9-10H2,1-3H3,(H,25,28)(H,23,24,26)/t12-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)(R132C)


(Homo sapiens (Human))
BDBM317536
PNG
(6-chloro-7-methoxy-3-[(1S)-1-({1-methyl-2-oxo-1H,2...)
Show SMILES COc1cc2[nH]c(=O)c(cc2cc1Cl)[C@H](C)Nc1ncc2COC(=O)N(C)c2n1
Show InChI InChI=1S/C19H18ClN5O4/c1-9(22-18-21-7-11-8-29-19(27)25(2)16(11)24-18)12-4-10-5-13(20)15(28-3)6-14(10)23-17(12)26/h4-7,9H,8H2,1-3H3,(H,23,26)(H,21,22,24)/t9-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



FORMA THERAPEUTICS, INC.

US Patent




US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317539
PNG
(6-chloro-3-[(1S)-1-{[3-(2-methylpropyl)-2-oxo-2H,3...)
Show SMILES CC(C)Cn1c2nc(N[C@@H](C)c3cc4cc(Cl)ccc4[nH]c3=O)ncc2oc1=O
Show InChI InChI=1S/C20H20ClN5O3/c1-10(2)9-26-17-16(29-20(26)28)8-22-19(25-17)23-11(3)14-7-12-6-13(21)4-5-15(12)24-18(14)27/h4-8,10-11H,9H2,1-3H3,(H,24,27)(H,22,23,25)/t11-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317536
PNG
(6-chloro-7-methoxy-3-[(1S)-1-({1-methyl-2-oxo-1H,2...)
Show SMILES COc1cc2[nH]c(=O)c(cc2cc1Cl)[C@H](C)Nc1ncc2COC(=O)N(C)c2n1
Show InChI InChI=1S/C19H18ClN5O4/c1-9(22-18-21-7-11-8-29-19(27)25(2)16(11)24-18)12-4-10-5-13(20)15(28-3)6-14(10)23-17(12)26/h4-7,9H,8H2,1-3H3,(H,23,26)(H,21,22,24)/t9-/m0/s1
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317541
PNG
(6-chloro-3-[(1S)-1-({3-methyl-2-oxo-2H,3H-[1,3]oxa...)
Show SMILES C[C@H](Nc1ncc2oc(=O)n(C)c2n1)c1cc2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C17H14ClN5O3/c1-8(11-6-9-5-10(18)3-4-12(9)21-15(11)24)20-16-19-7-13-14(22-16)23(2)17(25)26-13/h3-8H,1-2H3,(H,21,24)(H,19,20,22)/t8-/m0/s1
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)(R132C)


(Homo sapiens (Human))
BDBM317539
PNG
(6-chloro-3-[(1S)-1-{[3-(2-methylpropyl)-2-oxo-2H,3...)
Show SMILES CC(C)Cn1c2nc(N[C@@H](C)c3cc4cc(Cl)ccc4[nH]c3=O)ncc2oc1=O
Show InChI InChI=1S/C20H20ClN5O3/c1-10(2)9-26-17-16(29-20(26)28)8-22-19(25-17)23-11(3)14-7-12-6-13(21)4-5-15(12)24-18(14)27/h4-8,10-11H,9H2,1-3H3,(H,24,27)(H,22,23,25)/t11-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



FORMA THERAPEUTICS, INC.

US Patent




US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)(R132C)


(Homo sapiens (Human))
BDBM317532
PNG
(6-chloro-3-[(1S)-1-({1-methyl-2-oxo-1H,2H,4H-pyrim...)
Show SMILES C[C@H](Nc1ncc2COC(=O)N(C)c2n1)c1cc2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C18H16ClN5O3/c1-9(13-6-10-5-12(19)3-4-14(10)22-16(13)25)21-17-20-7-11-8-27-18(26)24(2)15(11)23-17/h3-7,9H,8H2,1-2H3,(H,22,25)(H,20,21,23)/t9-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



FORMA THERAPEUTICS, INC.

US Patent




US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317540
PNG
(6-chloro-3-[(1S)-1-({2-oxo-2H,3H-[1,3]oxazolo[4,5-...)
Show SMILES C[C@H](Nc1ncc2oc(=O)[nH]c2n1)c1cc2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C16H12ClN5O3/c1-7(19-15-18-6-12-13(21-15)22-16(24)25-12)10-5-8-4-9(17)2-3-11(8)20-14(10)23/h2-7H,1H3,(H,20,23)(H2,18,19,21,22,24)/t7-/m0/s1
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317535
PNG
(6-chloro-7-methoxy-3-[1-({1-methyl-2-oxo-1H,2H,4H-...)
Show SMILES COc1cc2[nH]c(=O)c(cc2cc1Cl)C(C)Nc1ncc2COC(=O)N(C)c2n1
Show InChI InChI=1S/C19H18ClN5O4/c1-9(22-18-21-7-11-8-29-19(27)25(2)16(11)24-18)12-4-10-5-13(20)15(28-3)6-14(10)23-17(12)26/h4-7,9H,8H2,1-3H3,(H,23,26)(H,21,22,24)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317534
PNG
(6-chloro-3-[(1S)-1-({2-oxo-1H,2H,4H-pyrimido[4,5-d...)
Show SMILES C[C@H](Nc1ncc2COC(=O)Nc2n1)c1cc2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C17H14ClN5O3/c1-8(12-5-9-4-11(18)2-3-13(9)21-15(12)24)20-16-19-6-10-7-26-17(25)23-14(10)22-16/h2-6,8H,7H2,1H3,(H,21,24)(H2,19,20,22,23,25)/t8-/m0/s1
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317532
PNG
(6-chloro-3-[(1S)-1-({1-methyl-2-oxo-1H,2H,4H-pyrim...)
Show SMILES C[C@H](Nc1ncc2COC(=O)N(C)c2n1)c1cc2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C18H16ClN5O3/c1-9(13-6-10-5-12(19)3-4-14(10)22-16(13)25)21-17-20-7-11-8-27-18(26)24(2)15(11)23-17/h3-7,9H,8H2,1-2H3,(H,22,25)(H,20,21,23)/t9-/m0/s1
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)(R132C)


(Homo sapiens (Human))
BDBM317534
PNG
(6-chloro-3-[(1S)-1-({2-oxo-1H,2H,4H-pyrimido[4,5-d...)
Show SMILES C[C@H](Nc1ncc2COC(=O)Nc2n1)c1cc2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C17H14ClN5O3/c1-8(12-5-9-4-11(18)2-3-13(9)21-15(12)24)20-16-19-6-10-7-26-17(25)23-14(10)22-16/h2-6,8H,7H2,1H3,(H,21,24)(H2,19,20,22,23,25)/t8-/m0/s1
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n/an/a 550n/an/an/an/an/an/a



FORMA THERAPEUTICS, INC.

US Patent




US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317486
PNG
(3-{[(1,3-benzoxazol-4-yl)amino]methyl}-6-chloro-1,...)
Show SMILES Clc1ccc2[nH]c(=O)c(CNc3cccc4ocnc34)cc2c1
Show InChI InChI=1S/C17H12ClN3O2/c18-12-4-5-13-10(7-12)6-11(17(22)21-13)8-19-14-2-1-3-15-16(14)20-9-23-15/h1-7,9,19H,8H2,(H,21,22)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317530
PNG
(6-chloro-3-[(1S)-1-({1H-pyrazolo[3,4-d]pyrimidin-6...)
Show SMILES C[C@H](Nc1ncc2cn[nH]c2n1)c1cc2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C16H13ClN6O/c1-8(20-16-18-6-10-7-19-23-14(10)22-16)12-5-9-4-11(17)2-3-13(9)21-15(12)24/h2-8H,1H3,(H,21,24)(H2,18,19,20,22,23)/t8-/m0/s1
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317488
PNG
(6-chloro-3-{[(2-oxo-2,3-dihydro-1,3-benzoxazol-5-y...)
Show SMILES Clc1ccc2[nH]c(=O)c(CNc3ccc4oc(=O)[nH]c4c3)cc2c1
Show InChI InChI=1S/C17H12ClN3O3/c18-11-1-3-13-9(6-11)5-10(16(22)20-13)8-19-12-2-4-15-14(7-12)21-17(23)24-15/h1-7,19H,8H2,(H,20,22)(H,21,23)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)(R132C)


(Homo sapiens (Human))
BDBM317486
PNG
(3-{[(1,3-benzoxazol-4-yl)amino]methyl}-6-chloro-1,...)
Show SMILES Clc1ccc2[nH]c(=O)c(CNc3cccc4ocnc34)cc2c1
Show InChI InChI=1S/C17H12ClN3O2/c18-12-4-5-13-10(7-12)6-11(17(22)21-13)8-19-14-2-1-3-15-16(14)20-9-23-15/h1-7,9,19H,8H2,(H,21,22)
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n/an/a 550n/an/an/an/an/an/a



FORMA THERAPEUTICS, INC.

US Patent




US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317542
PNG
(6-chloro-3-[(1S)-1-[(9-methyl-8-oxo-8,9-dihydro-7H...)
Show SMILES C[C@H](Nc1ncc2[nH]c(=O)n(C)c2n1)c1cc2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C17H15ClN6O2/c1-8(11-6-9-5-10(18)3-4-12(9)21-15(11)25)20-16-19-7-13-14(23-16)24(2)17(26)22-13/h3-8H,1-2H3,(H,21,25)(H,22,26)(H,19,20,23)/t8-/m0/s1
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n/an/a 550n/an/an/an/an/an/a



FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317537
PNG
(6-chloro-7-methoxy-3-[(1R)-1-({1-methyl-2-oxo-1H,2...)
Show SMILES COc1cc2[nH]c(=O)c(cc2cc1Cl)[C@@H](C)Nc1ncc2COC(=O)N(C)c2n1
Show InChI InChI=1S/C19H18ClN5O4/c1-9(22-18-21-7-11-8-29-19(27)25(2)16(11)24-18)12-4-10-5-13(20)15(28-3)6-14(10)23-17(12)26/h4-7,9H,8H2,1-3H3,(H,23,26)(H,21,22,24)/t9-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)(R132C)


(Homo sapiens (Human))
BDBM317541
PNG
(6-chloro-3-[(1S)-1-({3-methyl-2-oxo-2H,3H-[1,3]oxa...)
Show SMILES C[C@H](Nc1ncc2oc(=O)n(C)c2n1)c1cc2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C17H14ClN5O3/c1-8(11-6-9-5-10(18)3-4-12(9)21-15(11)24)20-16-19-7-13-14(22-16)23(2)17(25)26-13/h3-8H,1-2H3,(H,21,24)(H,19,20,22)/t8-/m0/s1
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n/an/a 550n/an/an/an/an/an/a



FORMA THERAPEUTICS, INC.

US Patent




US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317527
PNG
(3-[(1S)-1-({1-acetyl-1H,2H,3H-pyrrolo[3,2-c]pyridi...)
Show SMILES C[C@H](Nc1nccc2N(CCc12)C(C)=O)c1cc2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C20H19ClN4O2/c1-11(16-10-13-9-14(21)3-4-17(13)24-20(16)27)23-19-15-6-8-25(12(2)26)18(15)5-7-22-19/h3-5,7,9-11H,6,8H2,1-2H3,(H,22,23)(H,24,27)/t11-/m0/s1
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)(R132C)


(Homo sapiens (Human))
BDBM317545
PNG
(6-chloro-3-[(1S)-1-({7-methyl-6-oxo-5H,6H,7H-pyrro...)
Show SMILES C[C@H](Nc1ncc2CC(=O)N(C)c2n1)c1cc2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C18H16ClN5O2/c1-9(13-6-10-5-12(19)3-4-14(10)22-17(13)26)21-18-20-8-11-7-15(25)24(2)16(11)23-18/h3-6,8-9H,7H2,1-2H3,(H,22,26)(H,20,21,23)/t9-/m0/s1
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n/an/a 550n/an/an/an/an/an/a



FORMA THERAPEUTICS, INC.

US Patent




US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317490
PNG
(6-chloro-3-{[(1-methyl-2-oxo-1,2,3,4-tetrahydroqui...)
Show SMILES CN1C(=O)CCc2cc(NCc3cc4cc(Cl)ccc4[nH]c3=O)ccc12
Show InChI InChI=1S/C20H18ClN3O2/c1-24-18-6-4-16(10-12(18)2-7-19(24)25)22-11-14-8-13-9-15(21)3-5-17(13)23-20(14)26/h3-6,8-10,22H,2,7,11H2,1H3,(H,23,26)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)(R132C)


(Homo sapiens (Human))
BDBM317540
PNG
(6-chloro-3-[(1S)-1-({2-oxo-2H,3H-[1,3]oxazolo[4,5-...)
Show SMILES C[C@H](Nc1ncc2oc(=O)[nH]c2n1)c1cc2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C16H12ClN5O3/c1-7(19-15-18-6-12-13(21-15)22-16(24)25-12)10-5-8-4-9(17)2-3-11(8)20-14(10)23/h2-7H,1H3,(H,20,23)(H2,18,19,21,22,24)/t7-/m0/s1
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FORMA THERAPEUTICS, INC.

US Patent




US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317545
PNG
(6-chloro-3-[(1S)-1-({7-methyl-6-oxo-5H,6H,7H-pyrro...)
Show SMILES C[C@H](Nc1ncc2CC(=O)N(C)c2n1)c1cc2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C18H16ClN5O2/c1-9(13-6-10-5-12(19)3-4-14(10)22-17(13)26)21-18-20-8-11-7-15(25)24(2)16(11)23-18/h3-6,8-9H,7H2,1-2H3,(H,22,26)(H,20,21,23)/t9-/m0/s1
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317544
PNG
(6-chloro-3-[(1S)-1-({6-oxo-5H,6H,7H-pyrrolo[2,3-d]...)
Show SMILES C[C@H](Nc1ncc2CC(=O)Nc2n1)c1cc2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C17H14ClN5O2/c1-8(20-17-19-7-10-6-14(24)22-15(10)23-17)12-5-9-4-11(18)2-3-13(9)21-16(12)25/h2-5,7-8H,6H2,1H3,(H,21,25)(H2,19,20,22,23,24)/t8-/m0/s1
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317489
PNG
(6-chloro-3-{[(2-oxo-2H-chromen-6-yl)amino]methyl}-...)
Show SMILES Clc1ccc2[nH]c(=O)c(CNc3ccc4oc(=O)ccc4c3)cc2c1
Show InChI InChI=1S/C19H13ClN2O3/c20-14-2-4-16-12(8-14)7-13(19(24)22-16)10-21-15-3-5-17-11(9-15)1-6-18(23)25-17/h1-9,21H,10H2,(H,22,24)
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US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317487
PNG
(6-chloro-3-{[(3-methyl-2-oxo-2,3-dihydro-1,3-benzo...)
Show SMILES Cn1c2cc(NCc3cc4cc(Cl)ccc4[nH]c3=O)ccc2oc1=O
Show InChI InChI=1S/C18H14ClN3O3/c1-22-15-8-13(3-5-16(15)25-18(22)24)20-9-11-6-10-7-12(19)2-4-14(10)21-17(11)23/h2-8,20H,9H2,1H3,(H,21,23)
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US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317526
PNG
(6-tert-butyl-3-{[(1H-indazol-5-yl)amino]methyl}-1,...)
Show SMILES CC(C)(C)c1ccc2[nH]c(=O)c(CNc3ccc4[nH]ncc4c3)cc2c1
Show InChI InChI=1S/C21H22N4O/c1-21(2,3)16-4-6-18-13(9-16)8-15(20(26)24-18)11-22-17-5-7-19-14(10-17)12-23-25-19/h4-10,12,22H,11H2,1-3H3,(H,23,25)(H,24,26)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)(R132C)


(Homo sapiens (Human))
BDBM317527
PNG
(3-[(1S)-1-({1-acetyl-1H,2H,3H-pyrrolo[3,2-c]pyridi...)
Show SMILES C[C@H](Nc1nccc2N(CCc12)C(C)=O)c1cc2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C20H19ClN4O2/c1-11(16-10-13-9-14(21)3-4-17(13)24-20(16)27)23-19-15-6-8-25(12(2)26)18(15)5-7-22-19/h3-5,7,9-11H,6,8H2,1-2H3,(H,22,23)(H,24,27)/t11-/m0/s1
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FORMA THERAPEUTICS, INC.

US Patent




US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)(R132C)


(Homo sapiens (Human))
BDBM317537
PNG
(6-chloro-7-methoxy-3-[(1R)-1-({1-methyl-2-oxo-1H,2...)
Show SMILES COc1cc2[nH]c(=O)c(cc2cc1Cl)[C@@H](C)Nc1ncc2COC(=O)N(C)c2n1
Show InChI InChI=1S/C19H18ClN5O4/c1-9(22-18-21-7-11-8-29-19(27)25(2)16(11)24-18)12-4-10-5-13(20)15(28-3)6-14(10)23-17(12)26/h4-7,9H,8H2,1-3H3,(H,23,26)(H,21,22,24)/t9-/m1/s1
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FORMA THERAPEUTICS, INC.

US Patent




US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)(R132C)


(Homo sapiens (Human))
BDBM317542
PNG
(6-chloro-3-[(1S)-1-[(9-methyl-8-oxo-8,9-dihydro-7H...)
Show SMILES C[C@H](Nc1ncc2[nH]c(=O)n(C)c2n1)c1cc2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C17H15ClN6O2/c1-8(11-6-9-5-10(18)3-4-12(9)21-15(11)25)20-16-19-7-13-14(23-16)24(2)17(26)22-13/h3-8H,1-2H3,(H,21,25)(H,22,26)(H,19,20,23)/t8-/m0/s1
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FORMA THERAPEUTICS, INC.

US Patent




US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)(R132C)


(Homo sapiens (Human))
BDBM317530
PNG
(6-chloro-3-[(1S)-1-({1H-pyrazolo[3,4-d]pyrimidin-6...)
Show SMILES C[C@H](Nc1ncc2cn[nH]c2n1)c1cc2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C16H13ClN6O/c1-8(20-16-18-6-10-7-19-23-14(10)22-16)12-5-9-4-11(17)2-3-13(9)21-15(12)24/h2-8H,1H3,(H,21,24)(H2,18,19,20,22,23)/t8-/m0/s1
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FORMA THERAPEUTICS, INC.

US Patent




US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317493
PNG
(6-chloro-3-{[(quinolin-8-yl)amino]methyl}-1,2-dihy...)
Show SMILES Clc1ccc2[nH]c(=O)c(CNc3cccc4cccnc34)cc2c1
Show InChI InChI=1S/C19H14ClN3O/c20-15-6-7-16-13(10-15)9-14(19(24)23-16)11-22-17-5-1-3-12-4-2-8-21-18(12)17/h1-10,22H,11H2,(H,23,24)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317505
PNG
(6-chloro-3-{[(2-oxo-1,2,3,4-tetrahydroquinolin-6-y...)
Show SMILES Clc1ccc2[nH]c(=O)c(CNc3ccc4NC(=O)CCc4c3)cc2c1
Show InChI InChI=1S/C19H16ClN3O2/c20-14-2-4-17-12(8-14)7-13(19(25)23-17)10-21-15-3-5-16-11(9-15)1-6-18(24)22-16/h2-5,7-9,21H,1,6,10H2,(H,22,24)(H,23,25)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317538
PNG
(6-chloro-7-fluoro-3-[(1R)-1-({1-methyl-2-oxo-1H,2H...)
Show SMILES C[C@@H](Nc1ncc2COC(=O)N(C)c2n1)c1cc2cc(Cl)c(F)cc2[nH]c1=O
Show InChI InChI=1S/C18H15ClFN5O3/c1-8(11-3-9-4-12(19)13(20)5-14(9)23-16(11)26)22-17-21-6-10-7-28-18(27)25(2)15(10)24-17/h3-6,8H,7H2,1-2H3,(H,23,26)(H,21,22,24)/t8-/m1/s1
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)(R132C)


(Homo sapiens (Human))
BDBM317543
PNG
(6-chloro-3-[(1S)-1-[(8-oxo-8,9-dihydro-7H-purin-2-...)
Show SMILES C[C@H](Nc1ncc2[nH]c(=O)[nH]c2n1)c1cc2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C16H13ClN6O2/c1-7(19-15-18-6-12-13(22-15)23-16(25)21-12)10-5-8-4-9(17)2-3-11(8)20-14(10)24/h2-7H,1H3,(H,20,24)(H3,18,19,21,22,23,25)/t7-/m0/s1
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FORMA THERAPEUTICS, INC.

US Patent




US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317494
PNG
(6-chloro-3-{[(2,3-dihydro-1-benzofuran-7-yl)amino]...)
Show SMILES Clc1ccc2[nH]c(=O)c(CNc3cccc4CCOc34)cc2c1
Show InChI InChI=1S/C18H15ClN2O2/c19-14-4-5-15-12(9-14)8-13(18(22)21-15)10-20-16-3-1-2-11-6-7-23-17(11)16/h1-5,8-9,20H,6-7,10H2,(H,21,22)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317496
PNG
(7-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methy...)
Show SMILES Clc1ccc2[nH]c(=O)c(CNc3ccc4NC(=O)COc4c3)cc2c1
Show InChI InChI=1S/C18H14ClN3O3/c19-12-1-3-14-10(6-12)5-11(18(24)22-14)8-20-13-2-4-15-16(7-13)25-9-17(23)21-15/h1-7,20H,8-9H2,(H,21,23)(H,22,24)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)(R132C)


(Homo sapiens (Human))
BDBM317544
PNG
(6-chloro-3-[(1S)-1-({6-oxo-5H,6H,7H-pyrrolo[2,3-d]...)
Show SMILES C[C@H](Nc1ncc2CC(=O)Nc2n1)c1cc2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C17H14ClN5O2/c1-8(20-17-19-7-10-6-14(24)22-15(10)23-17)12-5-9-4-11(18)2-3-13(9)21-16(12)25/h2-5,7-8H,6H2,1H3,(H,21,25)(H2,19,20,22,23,24)/t8-/m0/s1
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FORMA THERAPEUTICS, INC.

US Patent




US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317491
PNG
(6-chloro-3-{[(isoquinolin-3-yl)amino]methyl}-1,2-d...)
Show SMILES Clc1ccc2[nH]c(=O)c(CNc3cc4ccccc4cn3)cc2c1
Show InChI InChI=1S/C19H14ClN3O/c20-16-5-6-17-14(8-16)7-15(19(24)23-17)11-22-18-9-12-3-1-2-4-13(12)10-21-18/h1-10H,11H2,(H,21,22)(H,23,24)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317495
PNG
(7-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methy...)
Show SMILES CN1C(=O)COc2cc(NCc3cc4cc(Cl)ccc4[nH]c3=O)ccc12
Show InChI InChI=1S/C19H16ClN3O3/c1-23-16-5-3-14(8-17(16)26-10-18(23)24)21-9-12-6-11-7-13(20)2-4-15(11)22-19(12)25/h2-8,21H,9-10H2,1H3,(H,22,25)
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n/an/a 5.50E+3n/an/an/an/an/an/a



FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317529
PNG
(3-[(1S)-1-({1-acetyl-1H,2H,3H-pyrido[3,4-b][1,4]ox...)
Show SMILES C[C@H](Nc1nccc2N(CCOc12)C(C)=O)c1cc2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C20H19ClN4O3/c1-11(15-10-13-9-14(21)3-4-16(13)24-20(15)27)23-19-18-17(5-6-22-19)25(12(2)26)7-8-28-18/h3-6,9-11H,7-8H2,1-2H3,(H,22,23)(H,24,27)/t11-/m0/s1
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n/an/a 5.50E+3n/an/an/an/an/an/a



FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317543
PNG
(6-chloro-3-[(1S)-1-[(8-oxo-8,9-dihydro-7H-purin-2-...)
Show SMILES C[C@H](Nc1ncc2[nH]c(=O)[nH]c2n1)c1cc2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C16H13ClN6O2/c1-7(19-15-18-6-12-13(22-15)23-16(25)21-12)10-5-8-4-9(17)2-3-11(8)20-14(10)24/h2-7H,1H3,(H,20,24)(H3,18,19,21,22,23,25)/t7-/m0/s1
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317492
PNG
(4-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methy...)
Show SMILES Clc1ccc2[nH]c(=O)c(CNc3ccc(C#N)c4ccccc34)cc2c1
Show InChI InChI=1S/C21H14ClN3O/c22-16-6-8-19-14(10-16)9-15(21(26)25-19)12-24-20-7-5-13(11-23)17-3-1-2-4-18(17)20/h1-10,24H,12H2,(H,25,26)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317546
PNG
(6-chloro-3-[(1S)-1-({7-oxo-5H,6H,7H,8H-pyrido[2,3-...)
Show SMILES C[C@H](Nc1ncc2CCC(=O)Nc2n1)c1cc2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C18H16ClN5O2/c1-9(13-7-11-6-12(19)3-4-14(11)22-17(13)26)21-18-20-8-10-2-5-15(25)23-16(10)24-18/h3-4,6-9H,2,5H2,1H3,(H,22,26)(H2,20,21,23,24,25)/t9-/m0/s1
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n/an/a 5.50E+3n/an/an/an/an/an/a



FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317528
PNG
(6-chloro-3-[(1S)-1-({1-methanesulfonyl-1H,2H,3H-py...)
Show SMILES C[C@H](Nc1nccc2N(CCc12)S(C)(=O)=O)c1cc2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C19H19ClN4O3S/c1-11(15-10-12-9-13(20)3-4-16(12)23-19(15)25)22-18-14-6-8-24(28(2,26)27)17(14)5-7-21-18/h3-5,7,9-11H,6,8H2,1-2H3,(H,21,22)(H,23,25)/t11-/m0/s1
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)(R132C)


(Homo sapiens (Human))
BDBM317546
PNG
(6-chloro-3-[(1S)-1-({7-oxo-5H,6H,7H,8H-pyrido[2,3-...)
Show SMILES C[C@H](Nc1ncc2CCC(=O)Nc2n1)c1cc2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C18H16ClN5O2/c1-9(13-7-11-6-12(19)3-4-14(11)22-17(13)26)21-18-20-8-10-2-5-15(25)23-16(10)24-18/h3-4,6-9H,2,5H2,1H3,(H,22,26)(H2,20,21,23,24,25)/t9-/m0/s1
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n/an/a 5.50E+3n/an/an/an/an/an/a



FORMA THERAPEUTICS, INC.

US Patent




US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317503
PNG
(6-chloro-3-{[(2-oxo-1,2,3,4-tetrahydroquinolin-7-y...)
Show SMILES Clc1ccc2[nH]c(=O)c(CNc3ccc4CCC(=O)Nc4c3)cc2c1
Show InChI InChI=1S/C19H16ClN3O2/c20-14-3-5-16-12(8-14)7-13(19(25)23-16)10-21-15-4-1-11-2-6-18(24)22-17(11)9-15/h1,3-5,7-9,21H,2,6,10H2,(H,22,24)(H,23,25)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317520
PNG
(6-methoxy-3-{[(2-methylquinolin-6-yl)amino]methyl}...)
Show SMILES COc1ccc2[nH]c(=O)c(CNc3ccc4nc(C)ccc4c3)cc2c1
Show InChI InChI=1S/C21H19N3O2/c1-13-3-4-14-10-17(5-7-19(14)23-13)22-12-16-9-15-11-18(26-2)6-8-20(15)24-21(16)25/h3-11,22H,12H2,1-2H3,(H,24,25)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317524
PNG
(6-methoxy-3-{[(quinolin-6-yl)amino]methyl}-1,2-dih...)
Show SMILES COc1ccc2[nH]c(=O)c(CNc3ccc4ncccc4c3)cc2c1
Show InChI InChI=1S/C20H17N3O2/c1-25-17-5-7-19-14(11-17)9-15(20(24)23-19)12-22-16-4-6-18-13(10-16)3-2-8-21-18/h2-11,22H,12H2,1H3,(H,23,24)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317518
PNG
(6-chloro-3-{[(2,3-dihydro-1,4-benzodioxin-6-yl)ami...)
Show SMILES Clc1ccc2[nH]c(=O)c(CNc3ccc4OCCOc4c3)cc2c1
Show InChI InChI=1S/C18H15ClN2O3/c19-13-1-3-15-11(8-13)7-12(18(22)21-15)10-20-14-2-4-16-17(9-14)24-6-5-23-16/h1-4,7-9,20H,5-6,10H2,(H,21,22)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317522
PNG
(6,7-dimethyl-3-{[(2-methylquinolin-6-yl)amino]meth...)
Show SMILES Cc1ccc2cc(NCc3cc4cc(C)c(C)cc4[nH]c3=O)ccc2n1
Show InChI InChI=1S/C22H21N3O/c1-13-8-17-10-18(22(26)25-21(17)9-14(13)2)12-23-19-6-7-20-16(11-19)5-4-15(3)24-20/h4-11,23H,12H2,1-3H3,(H,25,26)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317502
PNG
(6-chloro-3-{[(6-methoxy-2-oxo-1,2,3,4-tetrahydroqu...)
Show SMILES COc1cc2CCC(=O)Nc2cc1NCc1cc2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C20H18ClN3O3/c1-27-18-8-11-2-5-19(25)23-16(11)9-17(18)22-10-13-6-12-7-14(21)3-4-15(12)24-20(13)26/h3-4,6-9,22H,2,5,10H2,1H3,(H,23,25)(H,24,26)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317498
PNG
(6-chloro-3-{[(2-oxo-2,3-dihydro-1H-indol-6-yl)amin...)
Show SMILES Clc1ccc2[nH]c(=O)c(CNc3ccc4CC(=O)Nc4c3)cc2c1
Show InChI InChI=1S/C18H14ClN3O2/c19-13-2-4-15-11(6-13)5-12(18(24)22-15)9-20-14-3-1-10-7-17(23)21-16(10)8-14/h1-6,8,20H,7,9H2,(H,21,23)(H,22,24)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317500
PNG
(6-chloro-3-{[(isoquinolin-8-yl)amino]methyl}-1,2-d...)
Show SMILES Clc1ccc2[nH]c(=O)c(CNc3cccc4ccncc34)cc2c1
Show InChI InChI=1S/C19H14ClN3O/c20-15-4-5-17-13(9-15)8-14(19(24)23-17)10-22-18-3-1-2-12-6-7-21-11-16(12)18/h1-9,11,22H,10H2,(H,23,24)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317501
PNG
(6-chloro-3-{[(3,4-dihydro-2H-1-benzopyran-8-yl)ami...)
Show SMILES Clc1ccc2[nH]c(=O)c(CNc3cccc4CCCOc34)cc2c1
Show InChI InChI=1S/C19H17ClN2O2/c20-15-6-7-16-13(10-15)9-14(19(23)22-16)11-21-17-5-1-3-12-4-2-8-24-18(12)17/h1,3,5-7,9-10,21H,2,4,8,11H2,(H,22,23)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317519
PNG
(3-{[(1H-indazol-6-yl)amino]methyl}-6-methoxy-1,2-d...)
Show SMILES COc1ccc2[nH]c(=O)c(CNc3ccc4cn[nH]c4c3)cc2c1
Show InChI InChI=1S/C18H16N4O2/c1-24-15-4-5-16-12(7-15)6-13(18(23)21-16)9-19-14-3-2-11-10-20-22-17(11)8-14/h2-8,10,19H,9H2,1H3,(H,20,22)(H,21,23)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)(R132C)


(Homo sapiens (Human))
BDBM317538
PNG
(6-chloro-7-fluoro-3-[(1R)-1-({1-methyl-2-oxo-1H,2H...)
Show SMILES C[C@@H](Nc1ncc2COC(=O)N(C)c2n1)c1cc2cc(Cl)c(F)cc2[nH]c1=O
Show InChI InChI=1S/C18H15ClFN5O3/c1-8(11-3-9-4-12(19)13(20)5-14(9)23-16(11)26)22-17-21-6-10-7-28-18(27)25(2)15(10)24-17/h3-6,8H,7H2,1-2H3,(H,23,26)(H,21,22,24)/t8-/m1/s1
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FORMA THERAPEUTICS, INC.

US Patent




US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)(R132C)


(Homo sapiens (Human))
BDBM317489
PNG
(6-chloro-3-{[(2-oxo-2H-chromen-6-yl)amino]methyl}-...)
Show SMILES Clc1ccc2[nH]c(=O)c(CNc3ccc4oc(=O)ccc4c3)cc2c1
Show InChI InChI=1S/C19H13ClN2O3/c20-14-2-4-16-12(8-14)7-13(19(24)22-16)10-21-15-3-5-17-11(9-15)1-6-18(23)25-17/h1-9,21H,10H2,(H,22,24)
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FORMA THERAPEUTICS, INC.

US Patent




US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317506
PNG
(6-methoxy-3-{[(2-methyl-1,3-benzothiazol-5-yl)amin...)
Show SMILES COc1ccc2[nH]c(=O)c(CNc3ccc4sc(C)nc4c3)cc2c1
Show InChI InChI=1S/C19H17N3O2S/c1-11-21-17-9-14(3-6-18(17)25-11)20-10-13-7-12-8-15(24-2)4-5-16(12)22-19(13)23/h3-9,20H,10H2,1-2H3,(H,22,23)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317509
PNG
(3-{[(1H-1,3-benzodiazol-5-yl)amino]methyl}-6-chlor...)
Show SMILES Clc1ccc2[nH]c(=O)c(CNc3ccc4[nH]cnc4c3)cc2c1
Show InChI InChI=1S/C17H13ClN4O/c18-12-1-3-14-10(6-12)5-11(17(23)22-14)8-19-13-2-4-15-16(7-13)21-9-20-15/h1-7,9,19H,8H2,(H,20,21)(H,22,23)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317512
PNG
(6-chloro-3-{[(quinolin-6-yl)amino]methyl}-1,2-dihy...)
Show SMILES Clc1ccc2[nH]c(=O)c(CNc3ccc4ncccc4c3)cc2c1
Show InChI InChI=1S/C19H14ClN3O/c20-15-3-5-18-13(9-15)8-14(19(24)23-18)11-22-16-4-6-17-12(10-16)2-1-7-21-17/h1-10,22H,11H2,(H,23,24)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317514
PNG
(3-{[(1,3-benzothiazol-5-yl)amino]methyl}-6-chloro-...)
Show SMILES Clc1ccc2[nH]c(=O)c(CNc3ccc4scnc4c3)cc2c1
Show InChI InChI=1S/C17H12ClN3OS/c18-12-1-3-14-10(6-12)5-11(17(22)21-14)8-19-13-2-4-16-15(7-13)20-9-23-16/h1-7,9,19H,8H2,(H,21,22)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317521
PNG
(3-{[(1,3-benzothiazol-6-yl)amino]methyl}-6-methoxy...)
Show SMILES COc1ccc2[nH]c(=O)c(CNc3ccc4ncsc4c3)cc2c1
Show InChI InChI=1S/C18H15N3O2S/c1-23-14-3-5-15-11(7-14)6-12(18(22)21-15)9-19-13-2-4-16-17(8-13)24-10-20-16/h2-8,10,19H,9H2,1H3,(H,21,22)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317525
PNG
(3-{[(1,3-benzothiazol-6-yl)amino]methyl}-6,7-dimet...)
Show SMILES Cc1cc2cc(CNc3ccc4ncsc4c3)c(=O)[nH]c2cc1C
Show InChI InChI=1S/C19H17N3OS/c1-11-5-13-7-14(19(23)22-17(13)6-12(11)2)9-20-15-3-4-16-18(8-15)24-10-21-16/h3-8,10,20H,9H2,1-2H3,(H,22,23)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)(R132C)


(Homo sapiens (Human))
BDBM317529
PNG
(3-[(1S)-1-({1-acetyl-1H,2H,3H-pyrido[3,4-b][1,4]ox...)
Show SMILES C[C@H](Nc1nccc2N(CCOc12)C(C)=O)c1cc2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C20H19ClN4O3/c1-11(15-10-13-9-14(21)3-4-16(13)24-20(15)27)23-19-18-17(5-6-22-19)25(12(2)26)7-8-28-18/h3-6,9-11H,7-8H2,1-2H3,(H,22,23)(H,24,27)/t11-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



FORMA THERAPEUTICS, INC.

US Patent




US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317497
PNG
(3-({[2-(1H-1,3-benzodiazol-5-yl)-1H-1,3-benzodiazo...)
Show SMILES COc1cc2cc(CNc3ccc4[nH]c(nc4c3)-c3ccc4[nH]cnc4c3)c(=O)[nH]c2cc1OC
Show InChI InChI=1S/C26H22N6O3/c1-34-23-9-15-7-16(26(33)32-20(15)11-24(23)35-2)12-27-17-4-6-19-22(10-17)31-25(30-19)14-3-5-18-21(8-14)29-13-28-18/h3-11,13,27H,12H2,1-2H3,(H,28,29)(H,30,31)(H,32,33)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317499
PNG
(6-chloro-3-{[(3-methyl-2-oxo-2,3-dihydro-1,3-benzo...)
Show SMILES Cn1c2ccc(NCc3cc4cc(Cl)ccc4[nH]c3=O)cc2oc1=O
Show InChI InChI=1S/C18H14ClN3O3/c1-22-15-5-3-13(8-16(15)25-18(22)24)20-9-11-6-10-7-12(19)2-4-14(10)21-17(11)23/h2-8,20H,9H2,1H3,(H,21,23)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317504
PNG
(6-chloro-3-{[(3-methyl-1H-indazol-6-yl)amino]methy...)
Show SMILES Cc1n[nH]c2cc(NCc3cc4cc(Cl)ccc4[nH]c3=O)ccc12
Show InChI InChI=1S/C18H15ClN4O/c1-10-15-4-3-14(8-17(15)23-22-10)20-9-12-6-11-7-13(19)2-5-16(11)21-18(12)24/h2-8,20H,9H2,1H3,(H,21,24)(H,22,23)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317507
PNG
(6-chloro-3-{[(5-oxo-5,6,7,8-tetrahydronaphthalen-1...)
Show SMILES Clc1ccc2[nH]c(=O)c(CNc3cccc4C(=O)CCCc34)cc2c1
Show InChI InChI=1S/C20H17ClN2O2/c21-14-7-8-17-12(10-14)9-13(20(25)23-17)11-22-18-5-1-4-16-15(18)3-2-6-19(16)24/h1,4-5,7-10,22H,2-3,6,11H2,(H,23,25)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317511
PNG
(3-{[(1,3-benzothiazol-6-yl)amino]methyl}-6-chloro-...)
Show SMILES Clc1ccc2[nH]c(=O)c(CNc3ccc4ncsc4c3)cc2c1
Show InChI InChI=1S/C17H12ClN3OS/c18-12-1-3-14-10(6-12)5-11(17(22)21-14)8-19-13-2-4-15-16(7-13)23-9-20-15/h1-7,9,19H,8H2,(H,21,22)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317513
PNG
(6-chloro-3-({[2-(trifluoromethyl)-1H-1,3-benzodiaz...)
Show SMILES FC(F)(F)c1nc2cc(NCc3cc4cc(Cl)ccc4[nH]c3=O)ccc2[nH]1
Show InChI InChI=1S/C18H12ClF3N4O/c19-11-1-3-13-9(6-11)5-10(16(27)24-13)8-23-12-2-4-14-15(7-12)26-17(25-14)18(20,21)22/h1-7,23H,8H2,(H,24,27)(H,25,26)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317517
PNG
(6-chloro-3-{[(2-methylquinolin-6-yl)amino]methyl}-...)
Show SMILES Cc1ccc2cc(NCc3cc4cc(Cl)ccc4[nH]c3=O)ccc2n1
Show InChI InChI=1S/C20H16ClN3O/c1-12-2-3-13-10-17(5-7-18(13)23-12)22-11-15-8-14-9-16(21)4-6-19(14)24-20(15)25/h2-10,22H,11H2,1H3,(H,24,25)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317510
PNG
(6-chloro-3-{[(1H-indazol-6-yl)amino]methyl}-1,2-di...)
Show SMILES Clc1ccc2[nH]c(=O)c(CNc3ccc4cn[nH]c4c3)cc2c1
Show InChI InChI=1S/C17H13ClN4O/c18-13-2-4-15-11(6-13)5-12(17(23)21-15)8-19-14-3-1-10-9-20-22-16(10)7-14/h1-7,9,19H,8H2,(H,20,22)(H,21,23)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317515
PNG
(3-{[(2,3-dihydro-1,4-benzodioxin-6-yl)amino]methyl...)
Show SMILES COc1ccc2[nH]c(=O)c(CNc3ccc4OCCOc4c3)cc2c1
Show InChI InChI=1S/C19H18N2O4/c1-23-15-3-4-16-12(9-15)8-13(19(22)21-16)11-20-14-2-5-17-18(10-14)25-7-6-24-17/h2-5,8-10,20H,6-7,11H2,1H3,(H,21,22)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317516
PNG
(3-{[(1H-indazol-6-yl)amino]methyl}-6,7-dimethyl-1,...)
Show SMILES Cc1cc2cc(CNc3ccc4cn[nH]c4c3)c(=O)[nH]c2cc1C
Show InChI InChI=1S/C19H18N4O/c1-11-5-14-7-15(19(24)22-17(14)6-12(11)2)9-20-16-4-3-13-10-21-23-18(13)8-16/h3-8,10,20H,9H2,1-2H3,(H,21,23)(H,22,24)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317508
PNG
(6-chloro-3-[({[1,2,4]triazolo[4,3-b]pyridazin-6-yl...)
Show SMILES Clc1ccc2[nH]c(=O)c(CNc3ccc4nncn4n3)cc2c1
Show InChI InChI=1S/C15H11ClN6O/c16-11-1-2-12-9(6-11)5-10(15(23)19-12)7-17-13-3-4-14-20-18-8-22(14)21-13/h1-6,8H,7H2,(H,17,21)(H,19,23)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (human))
BDBM317523
PNG
(6-chloro-3-{[(1H-indazol-5-yl)amino]methyl}-1,2-di...)
Show SMILES Clc1ccc2[nH]c(=O)c(CNc3ccc4[nH]ncc4c3)cc2c1
Show InChI InChI=1S/C17H13ClN4O/c18-13-1-3-15-10(6-13)5-12(17(23)21-15)8-19-14-2-4-16-11(7-14)9-20-22-16/h1-7,9,19H,8H2,(H,20,22)(H,21,23)
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FORMA THERAPEUTICS, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US9624175 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%