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Patent code US9624210

Compile Data Set for Download or QSAR
Found 3 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM317638
PNG
(5-hydroxy-5-(5-(3-methyl-5-((4-(trifluoromethyl)py...)
Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(s1)C1(O)CCCc2cc(ccc12)C(O)=O
Show InChI InChI=1S/C26H21F3N4O3S/c1-14-9-17(12-18(10-14)32-24-30-8-6-21(33-24)26(27,28)29)20-13-31-23(37-20)25(36)7-2-3-15-11-16(22(34)35)4-5-19(15)25/h4-6,8-13,36H,2-3,7H2,1H3,(H,34,35)(H,30,32,33)
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PC cid
PC sid
UniChem
US Patent
n/an/a<0.508n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...


US Patent US9624210 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM317640
PNG
((R)-5-hydroxy-5-(5-(3-methyl-5-((4-(trifluoromethy...)
Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(s1)[C@@]1(O)CCCc2cc(ccc12)C(O)=O
Show InChI InChI=1S/C26H21F3N4O3S/c1-14-9-17(12-18(10-14)32-24-30-8-6-21(33-24)26(27,28)29)20-13-31-23(37-20)25(36)7-2-3-15-11-16(22(34)35)4-5-19(15)25/h4-6,8-13,36H,2-3,7H2,1H3,(H,34,35)(H,30,32,33)/t25-/m1/s1
PDB
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PC cid
PC sid
UniChem
US Patent
n/an/a<0.508n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...


US Patent US9624210 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM317639
PNG
((S)-5-hydroxy-5-(5-(3-methyl-5-((4-(trifluoromethy...)
Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(s1)[C@]1(O)CCCc2cc(ccc12)C(O)=O
Show InChI InChI=1S/C26H21F3N4O3S/c1-14-9-17(12-18(10-14)32-24-30-8-6-21(33-24)26(27,28)29)20-13-31-23(37-20)25(36)7-2-3-15-11-16(22(34)35)4-5-19(15)25/h4-6,8-13,36H,2-3,7H2,1H3,(H,34,35)(H,30,32,33)/t25-/m0/s1
PDB
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UniProtKB/SwissProt

B.MOAD
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PC cid
PC sid
UniChem
US Patent
n/an/a 1.60n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...


US Patent US9624210 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%