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Patent code US9624218

Compile Data Set for Download or QSAR
Found 112 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318008
PNG
(2-[4-[(3-Chloro-2-pyridyl)methyl]piperazin-1-yl]-8...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2Cl)CC1
Show InChI InChI=1S/C18H23ClN6O/c1-23-7-3-4-13-16(23)21-18(22-17(13)26)25-10-8-24(9-11-25)12-15-14(19)5-2-6-20-15/h2,5-6H,3-4,7-12H2,1H3,(H,21,22,26)
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US Patent
n/an/a 6.25n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318009
PNG
(2-[4-[(3-Bromo-2- pyridyl)methyl]piperazin-1- yl]-...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2Br)CC1
Show InChI InChI=1S/C18H23BrN6O/c1-23-7-3-4-13-16(23)21-18(22-17(13)26)25-10-8-24(9-11-25)12-15-14(19)5-2-6-20-15/h2,5-6H,3-4,7-12H2,1H3,(H,21,22,26)
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US Patent
n/an/a 6.58n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318034
PNG
(8-Methyl-2-[4-[[3-trifluoromethyl)-2- pyridyl]meth...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccc2C(F)(F)F)CC1
Show InChI InChI=1S/C20H24F3N5O/c1-26-8-4-6-15-17(26)24-19(25-18(15)29)28-11-9-27(10-12-28)13-14-5-2-3-7-16(14)20(21,22)23/h2-3,5,7H,4,6,8-13H2,1H3,(H,24,25,29)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318039
PNG
(2-[[4-(8-Methyl-4-oxo-3,5,6,7-tetrahydropyrido[2,3...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2C#N)CC1
Show InChI InChI=1S/C19H23N7O/c1-24-7-3-5-15-17(24)22-19(23-18(15)27)26-10-8-25(9-11-26)13-16-14(12-20)4-2-6-21-16/h2,4,6H,3,5,7-11,13H2,1H3,(H,22,23,27)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318007
PNG
(8-Methyl-2-[4-(pyrimidin-2-ylmethyl)piperazin-1-yl...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccn2)CC1
Show InChI InChI=1S/C17H23N7O/c1-22-7-2-4-13-15(22)20-17(21-16(13)25)24-10-8-23(9-11-24)12-14-18-5-3-6-19-14/h3,5-6H,2,4,7-12H2,1H3,(H,20,21,25)
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n/an/a 9.95n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318040
PNG
(2-[4-[(4-Chloropyrimidin-2-yl)methyl]piperazin-1-y...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2nccc(Cl)n2)CC1
Show InChI InChI=1S/C17H22ClN7O/c1-23-6-2-3-12-15(23)21-17(22-16(12)26)25-9-7-24(8-10-25)11-14-19-5-4-13(18)20-14/h4-5H,2-3,6-11H2,1H3,(H,21,22,26)
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US Patent
n/an/a 10.6n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318008
PNG
(2-[4-[(3-Chloro-2-pyridyl)methyl]piperazin-1-yl]-8...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2Cl)CC1
Show InChI InChI=1S/C18H23ClN6O/c1-23-7-3-4-13-16(23)21-18(22-17(13)26)25-10-8-24(9-11-25)12-15-14(19)5-2-6-20-15/h2,5-6H,3-4,7-12H2,1H3,(H,21,22,26)
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n/an/a 10.7n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318036
PNG
(2-[[4-(8-Methyl-4-oxo-3,5,6,7-tetrahydropyrido[2,3...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccc2C#N)CC1
Show InChI InChI=1S/C20H24N6O/c1-24-8-4-7-17-18(24)22-20(23-19(17)27)26-11-9-25(10-12-26)14-16-6-3-2-5-15(16)13-21/h2-3,5-6H,4,7-12,14H2,1H3,(H,22,23,27)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318009
PNG
(2-[4-[(3-Bromo-2- pyridyl)methyl]piperazin-1- yl]-...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2Br)CC1
Show InChI InChI=1S/C18H23BrN6O/c1-23-7-3-4-13-16(23)21-18(22-17(13)26)25-10-8-24(9-11-25)12-15-14(19)5-2-6-20-15/h2,5-6H,3-4,7-12H2,1H3,(H,21,22,26)
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n/an/a 10.9n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318026
PNG
(2-[4-[(3-Fluoro-2-pyridyl)methyl]piperazin-1-yl]-8...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2F)CC1
Show InChI InChI=1S/C18H23FN6O/c1-23-7-3-4-13-16(23)21-18(22-17(13)26)25-10-8-24(9-11-25)12-15-14(19)5-2-6-20-15/h2,5-6H,3-4,7-12H2,1H3,(H,21,22,26)
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US Patent
n/an/a 11.3n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318010
PNG
(2-[4-[(3-Hydroxy-2- pyridyl)methyl]piperazin-1- yl...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2O)CC1
Show InChI InChI=1S/C18H24N6O2/c1-22-7-3-4-13-16(22)20-18(21-17(13)26)24-10-8-23(9-11-24)12-14-15(25)5-2-6-19-14/h2,5-6,25H,3-4,7-12H2,1H3,(H,20,21,26)
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US Patent
n/an/a 11.6n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318025
PNG
(US9624218, Example 19 | US9624218, Example 34)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccn2)CC1
Show InChI InChI=1S/C18H24N6O/c1-22-8-4-6-15-16(22)20-18(21-17(15)25)24-11-9-23(10-12-24)13-14-5-2-3-7-19-14/h2-3,5,7H,4,6,8-13H2,1H3,(H,20,21,25)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318020
PNG
(8-Methyl-2-[4-[(4- methylpyrimidin-2- yl)methyl]pi...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2nccc(C)n2)CC1
Show InChI InChI=1S/C18H25N7O/c1-13-5-6-19-15(20-13)12-24-8-10-25(11-9-24)18-21-16-14(17(26)22-18)4-3-7-23(16)2/h5-6H,3-4,7-12H2,1-2H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318025
PNG
(US9624218, Example 19 | US9624218, Example 34)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccn2)CC1
Show InChI InChI=1S/C18H24N6O/c1-22-8-4-6-15-16(22)20-18(21-17(15)25)24-11-9-23(10-12-24)13-14-5-2-3-7-19-14/h2-3,5,7H,4,6,8-13H2,1H3,(H,20,21,25)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318030
PNG
(8-Methyl-2-[4-(o- tolylmethyl)piperazin-1-yl]- 3,5...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccc2C)CC1
Show InChI InChI=1S/C20H27N5O/c1-15-6-3-4-7-16(15)14-24-10-12-25(13-11-24)20-21-18-17(19(26)22-20)8-5-9-23(18)2/h3-4,6-7H,5,8-14H2,1-2H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318019
PNG
(2-[4-[(4-methoxypyrimidin-2-yl)methyl]piperazin-1-...)
Show SMILES COc1ccnc(CN2CCN(CC2)c2nc3N(C)CCCc3c(=O)[nH]2)n1
Show InChI InChI=1S/C18H25N7O2/c1-23-7-3-4-13-16(23)21-18(22-17(13)26)25-10-8-24(9-11-25)12-14-19-6-5-15(20-14)27-2/h5-6H,3-4,7-12H2,1-2H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318042
PNG
(2-[4-[(3-Chloropyrazin-2- yl)methyl]piperazin-l-yl...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2nccnc2Cl)CC1
Show InChI InChI=1S/C17H22ClN7O/c1-23-6-2-3-12-15(23)21-17(22-16(12)26)25-9-7-24(8-10-25)11-13-14(18)20-5-4-19-13/h4-5H,2-3,6-11H2,1H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318043
PNG
(8-Methyl-2-[4-[(3-methyl- pyrazin-2-yl)methyl]pipe...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2nccnc2C)CC1
Show InChI InChI=1S/C18H25N7O/c1-13-15(20-6-5-19-13)12-24-8-10-25(11-9-24)18-21-16-14(17(26)22-18)4-3-7-23(16)2/h5-6H,3-4,7-12H2,1-2H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318041
PNG
(8-Methyl-2-[4-(pyrazin-2-ylmethyl)piperazin-1-yl]-...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2cnccn2)CC1
Show InChI InChI=1S/C17H23N7O/c1-22-6-2-3-14-15(22)20-17(21-16(14)25)24-9-7-23(8-10-24)12-13-11-18-4-5-19-13/h4-5,11H,2-3,6-10,12H2,1H3,(H,20,21,25)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318007
PNG
(8-Methyl-2-[4-(pyrimidin-2-ylmethyl)piperazin-1-yl...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccn2)CC1
Show InChI InChI=1S/C17H23N7O/c1-22-7-2-4-13-15(22)20-17(21-16(13)25)24-10-8-23(9-11-24)12-14-18-5-3-6-19-14/h3,5-6H,2,4,7-12H2,1H3,(H,20,21,25)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318028
PNG
(2-[4-[(2- Methoxyphenyl)methyl]piperazin- 1-yl]-8-...)
Show SMILES COc1ccccc1CN1CCN(CC1)c1nc2N(C)CCCc2c(=O)[nH]1
Show InChI InChI=1S/C20H27N5O2/c1-23-9-5-7-16-18(23)21-20(22-19(16)26)25-12-10-24(11-13-25)14-15-6-3-4-8-17(15)27-2/h3-4,6,8H,5,7,9-14H2,1-2H3,(H,21,22,26)
PDB

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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318039
PNG
(2-[[4-(8-Methyl-4-oxo-3,5,6,7-tetrahydropyrido[2,3...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2C#N)CC1
Show InChI InChI=1S/C19H23N7O/c1-24-7-3-5-15-17(24)22-19(23-18(15)27)26-10-8-25(9-11-26)13-16-14(12-20)4-2-6-21-16/h2,4,6H,3,5,7-11,13H2,1H3,(H,22,23,27)
PDB

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n/an/a 14.3n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318040
PNG
(2-[4-[(4-Chloropyrimidin-2-yl)methyl]piperazin-1-y...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2nccc(Cl)n2)CC1
Show InChI InChI=1S/C17H22ClN7O/c1-23-6-2-3-12-15(23)21-17(22-16(12)26)25-9-7-24(8-10-25)11-14-19-5-4-13(18)20-14/h4-5H,2-3,6-11H2,1H3,(H,21,22,26)
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n/an/a 14.5n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318019
PNG
(2-[4-[(4-methoxypyrimidin-2-yl)methyl]piperazin-1-...)
Show SMILES COc1ccnc(CN2CCN(CC2)c2nc3N(C)CCCc3c(=O)[nH]2)n1
Show InChI InChI=1S/C18H25N7O2/c1-23-7-3-4-13-16(23)21-18(22-17(13)26)25-10-8-24(9-11-25)12-14-19-6-5-15(20-14)27-2/h5-6H,3-4,7-12H2,1-2H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318030
PNG
(8-Methyl-2-[4-(o- tolylmethyl)piperazin-1-yl]- 3,5...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccc2C)CC1
Show InChI InChI=1S/C20H27N5O/c1-15-6-3-4-7-16(15)14-24-10-12-25(13-11-24)20-21-18-17(19(26)22-20)8-5-9-23(18)2/h3-4,6-7H,5,8-14H2,1-2H3,(H,21,22,26)
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n/an/a 15.2n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318038
PNG
(2-[4-[(5-Fluoropyrimidin-2-yl)methyl]piperazin-1-y...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncc(F)cn2)CC1
Show InChI InChI=1S/C17H22FN7O/c1-23-4-2-3-13-15(23)21-17(22-16(13)26)25-7-5-24(6-8-25)11-14-19-9-12(18)10-20-14/h9-10H,2-8,11H2,1H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318021
PNG
(8-Methyl-2-[4-[[5-trifluoromethyl)pyrimidin-2- yl]...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncc(cn2)C(F)(F)F)CC1
Show InChI InChI=1S/C18H22F3N7O/c1-26-4-2-3-13-15(26)24-17(25-16(13)29)28-7-5-27(6-8-28)11-14-22-9-12(10-23-14)18(19,20)21/h9-10H,2-8,11H2,1H3,(H,24,25,29)
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n/an/a 16.7n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318007
PNG
(8-Methyl-2-[4-(pyrimidin-2-ylmethyl)piperazin-1-yl...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccn2)CC1
Show InChI InChI=1S/C17H23N7O/c1-22-7-2-4-13-15(22)20-17(21-16(13)25)24-10-8-23(9-11-24)12-14-18-5-3-6-19-14/h3,5-6H,2,4,7-12H2,1H3,(H,20,21,25)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318043
PNG
(8-Methyl-2-[4-[(3-methyl- pyrazin-2-yl)methyl]pipe...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2nccnc2C)CC1
Show InChI InChI=1S/C18H25N7O/c1-13-15(20-6-5-19-13)12-24-8-10-25(11-9-24)18-21-16-14(17(26)22-18)4-3-7-23(16)2/h5-6H,3-4,7-12H2,1-2H3,(H,21,22,26)
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n/an/a 17.6n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318034
PNG
(8-Methyl-2-[4-[[3-trifluoromethyl)-2- pyridyl]meth...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccc2C(F)(F)F)CC1
Show InChI InChI=1S/C20H24F3N5O/c1-26-8-4-6-15-17(26)24-19(25-18(15)29)28-11-9-27(10-12-28)13-14-5-2-3-7-16(14)20(21,22)23/h2-3,5,7H,4,6,8-13H2,1H3,(H,24,25,29)
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n/an/a 17.6n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318028
PNG
(2-[4-[(2- Methoxyphenyl)methyl]piperazin- 1-yl]-8-...)
Show SMILES COc1ccccc1CN1CCN(CC1)c1nc2N(C)CCCc2c(=O)[nH]1
Show InChI InChI=1S/C20H27N5O2/c1-23-9-5-7-16-18(23)21-20(22-19(16)26)25-12-10-24(11-13-25)14-15-6-3-4-8-17(15)27-2/h3-4,6,8H,5,7,9-14H2,1-2H3,(H,21,22,26)
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n/an/a 18.4n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318007
PNG
(8-Methyl-2-[4-(pyrimidin-2-ylmethyl)piperazin-1-yl...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccn2)CC1
Show InChI InChI=1S/C17H23N7O/c1-22-7-2-4-13-15(22)20-17(21-16(13)25)24-10-8-23(9-11-24)12-14-18-5-3-6-19-14/h3,5-6H,2,4,7-12H2,1H3,(H,20,21,25)
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n/an/a 19.1n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318044
PNG
(US9624218, Example 45)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncc(F)cc2F)CC1
Show InChI InChI=1S/C18H22F2N6O/c1-24-4-2-3-13-16(24)22-18(23-17(13)27)26-7-5-25(6-8-26)11-15-14(20)9-12(19)10-21-15/h9-10H,2-8,11H2,1H3,(H,22,23,27)
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n/an/a 19.6n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318036
PNG
(2-[[4-(8-Methyl-4-oxo-3,5,6,7-tetrahydropyrido[2,3...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccc2C#N)CC1
Show InChI InChI=1S/C20H24N6O/c1-24-8-4-7-17-18(24)22-20(23-19(17)27)26-11-9-25(10-12-26)14-16-6-3-2-5-15(16)13-21/h2-3,5-6H,4,7-12,14H2,1H3,(H,22,23,27)
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n/an/a 19.8n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318041
PNG
(8-Methyl-2-[4-(pyrazin-2-ylmethyl)piperazin-1-yl]-...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2cnccn2)CC1
Show InChI InChI=1S/C17H23N7O/c1-22-6-2-3-14-15(22)20-17(21-16(14)25)24-9-7-23(8-10-24)12-13-11-18-4-5-19-13/h4-5,11H,2-3,6-10,12H2,1H3,(H,20,21,25)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318025
PNG
(US9624218, Example 19 | US9624218, Example 34)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccn2)CC1
Show InChI InChI=1S/C18H24N6O/c1-22-8-4-6-15-16(22)20-18(21-17(15)25)24-11-9-23(10-12-24)13-14-5-2-3-7-19-14/h2-3,5,7H,4,6,8-13H2,1H3,(H,20,21,25)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318034
PNG
(8-Methyl-2-[4-[[3-trifluoromethyl)-2- pyridyl]meth...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccc2C(F)(F)F)CC1
Show InChI InChI=1S/C20H24F3N5O/c1-26-8-4-6-15-17(26)24-19(25-18(15)29)28-11-9-27(10-12-28)13-14-5-2-3-7-16(14)20(21,22)23/h2-3,5,7H,4,6,8-13H2,1H3,(H,24,25,29)
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n/an/a 21.6n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318017
PNG
(8-Methyl-2-[4-(1-pyrimidin-2-ylpropyl)piperazin-1-...)
Show SMILES CCC(N1CCN(CC1)c1nc2N(C)CCCc2c(=O)[nH]1)c1ncccn1
Show InChI InChI=1S/C19H27N7O/c1-3-15(16-20-7-5-8-21-16)25-10-12-26(13-11-25)19-22-17-14(18(27)23-19)6-4-9-24(17)2/h5,7-8,15H,3-4,6,9-13H2,1-2H3,(H,22,23,27)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318031
PNG
(8-Methyl-2-[4-[(3-methyl-2- pyridyl)methyl]piperaz...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2C)CC1
Show InChI InChI=1S/C19H26N6O/c1-14-5-3-7-20-16(14)13-24-9-11-25(12-10-24)19-21-17-15(18(26)22-19)6-4-8-23(17)2/h3,5,7H,4,6,8-13H2,1-2H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318020
PNG
(8-Methyl-2-[4-[(4- methylpyrimidin-2- yl)methyl]pi...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2nccc(C)n2)CC1
Show InChI InChI=1S/C18H25N7O/c1-13-5-6-19-15(20-13)12-24-8-10-25(11-9-24)18-21-16-14(17(26)22-18)4-3-7-23(16)2/h5-6H,3-4,7-12H2,1-2H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318029
PNG
(2-[4-[(2- Fluorophenyl)methyl]piperazin-1- yl]-8-m...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccc2F)CC1
Show InChI InChI=1S/C19H24FN5O/c1-23-8-4-6-15-17(23)21-19(22-18(15)26)25-11-9-24(10-12-25)13-14-5-2-3-7-16(14)20/h2-3,5,7H,4,6,8-13H2,1H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318017
PNG
(8-Methyl-2-[4-(1-pyrimidin-2-ylpropyl)piperazin-1-...)
Show SMILES CCC(N1CCN(CC1)c1nc2N(C)CCCc2c(=O)[nH]1)c1ncccn1
Show InChI InChI=1S/C19H27N7O/c1-3-15(16-20-7-5-8-21-16)25-10-12-26(13-11-25)19-22-17-14(18(27)23-19)6-4-9-24(17)2/h5,7-8,15H,3-4,6,9-13H2,1-2H3,(H,22,23,27)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318021
PNG
(8-Methyl-2-[4-[[5-trifluoromethyl)pyrimidin-2- yl]...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncc(cn2)C(F)(F)F)CC1
Show InChI InChI=1S/C18H22F3N7O/c1-26-4-2-3-13-15(26)24-17(25-16(13)29)28-7-5-27(6-8-28)11-14-22-9-12(10-23-14)18(19,20)21/h9-10H,2-8,11H2,1H3,(H,24,25,29)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318034
PNG
(8-Methyl-2-[4-[[3-trifluoromethyl)-2- pyridyl]meth...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccc2C(F)(F)F)CC1
Show InChI InChI=1S/C20H24F3N5O/c1-26-8-4-6-15-17(26)24-19(25-18(15)29)28-11-9-27(10-12-28)13-14-5-2-3-7-16(14)20(21,22)23/h2-3,5,7H,4,6,8-13H2,1H3,(H,24,25,29)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318010
PNG
(2-[4-[(3-Hydroxy-2- pyridyl)methyl]piperazin-1- yl...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2O)CC1
Show InChI InChI=1S/C18H24N6O2/c1-22-7-3-4-13-16(22)20-18(21-17(13)26)24-10-8-23(9-11-24)12-14-15(25)5-2-6-19-14/h2,5-6,25H,3-4,7-12H2,1H3,(H,20,21,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318032
PNG
(2-[4-[(3-Methoxy-2- pyridyl)methyl]piperazin-1-yl]...)
Show SMILES COc1cccnc1CN1CCN(CC1)c1nc2N(C)CCCc2c(=O)[nH]1
Show InChI InChI=1S/C19H26N6O2/c1-23-8-4-5-14-17(23)21-19(22-18(14)26)25-11-9-24(10-12-25)13-15-16(27-2)6-3-7-20-15/h3,6-7H,4-5,8-13H2,1-2H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318017
PNG
(8-Methyl-2-[4-(1-pyrimidin-2-ylpropyl)piperazin-1-...)
Show SMILES CCC(N1CCN(CC1)c1nc2N(C)CCCc2c(=O)[nH]1)c1ncccn1
Show InChI InChI=1S/C19H27N7O/c1-3-15(16-20-7-5-8-21-16)25-10-12-26(13-11-25)19-22-17-14(18(27)23-19)6-4-9-24(17)2/h5,7-8,15H,3-4,6,9-13H2,1-2H3,(H,22,23,27)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318026
PNG
(2-[4-[(3-Fluoro-2-pyridyl)methyl]piperazin-1-yl]-8...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2F)CC1
Show InChI InChI=1S/C18H23FN6O/c1-23-7-3-4-13-16(23)21-18(22-17(13)26)25-10-8-24(9-11-25)12-15-14(19)5-2-6-20-15/h2,5-6H,3-4,7-12H2,1H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318037
PNG
(2-[4-[(2-Chlorophenyl)methyl]piperazin-1-yl]-8-met...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccc2Cl)CC1
Show InChI InChI=1S/C19H24ClN5O/c1-23-8-4-6-15-17(23)21-19(22-18(15)26)25-11-9-24(10-12-25)13-14-5-2-3-7-16(14)20/h2-3,5,7H,4,6,8-13H2,1H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318038
PNG
(2-[4-[(5-Fluoropyrimidin-2-yl)methyl]piperazin-1-y...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncc(F)cn2)CC1
Show InChI InChI=1S/C17H22FN7O/c1-23-4-2-3-13-15(23)21-17(22-16(13)26)25-7-5-24(6-8-25)11-14-19-9-12(18)10-20-14/h9-10H,2-8,11H2,1H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318026
PNG
(2-[4-[(3-Fluoro-2-pyridyl)methyl]piperazin-1-yl]-8...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2F)CC1
Show InChI InChI=1S/C18H23FN6O/c1-23-7-3-4-13-16(23)21-18(22-17(13)26)25-10-8-24(9-11-25)12-15-14(19)5-2-6-20-15/h2,5-6H,3-4,7-12H2,1H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318017
PNG
(8-Methyl-2-[4-(1-pyrimidin-2-ylpropyl)piperazin-1-...)
Show SMILES CCC(N1CCN(CC1)c1nc2N(C)CCCc2c(=O)[nH]1)c1ncccn1
Show InChI InChI=1S/C19H27N7O/c1-3-15(16-20-7-5-8-21-16)25-10-12-26(13-11-25)19-22-17-14(18(27)23-19)6-4-9-24(17)2/h5,7-8,15H,3-4,6,9-13H2,1-2H3,(H,22,23,27)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318042
PNG
(2-[4-[(3-Chloropyrazin-2- yl)methyl]piperazin-l-yl...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2nccnc2Cl)CC1
Show InChI InChI=1S/C17H22ClN7O/c1-23-6-2-3-12-15(23)21-17(22-16(12)26)25-9-7-24(8-10-25)11-13-14(18)20-5-4-19-13/h4-5H,2-3,6-11H2,1H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318032
PNG
(2-[4-[(3-Methoxy-2- pyridyl)methyl]piperazin-1-yl]...)
Show SMILES COc1cccnc1CN1CCN(CC1)c1nc2N(C)CCCc2c(=O)[nH]1
Show InChI InChI=1S/C19H26N6O2/c1-23-8-4-5-14-17(23)21-19(22-18(14)26)25-11-9-24(10-12-25)13-15-16(27-2)6-3-7-20-15/h3,6-7H,4-5,8-13H2,1-2H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318026
PNG
(2-[4-[(3-Fluoro-2-pyridyl)methyl]piperazin-1-yl]-8...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2F)CC1
Show InChI InChI=1S/C18H23FN6O/c1-23-7-3-4-13-16(23)21-18(22-17(13)26)25-10-8-24(9-11-25)12-15-14(19)5-2-6-20-15/h2,5-6H,3-4,7-12H2,1H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318013
PNG
(8-Methyl-2-[4-(1-pyrimidin-2-ylethyl)piperazin-1-y...)
Show SMILES CC(N1CCN(CC1)c1nc2N(C)CCCc2c(=O)[nH]1)c1ncccn1
Show InChI InChI=1S/C18H25N7O/c1-13(15-19-6-4-7-20-15)24-9-11-25(12-10-24)18-21-16-14(17(26)22-18)5-3-8-23(16)2/h4,6-7,13H,3,5,8-12H2,1-2H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318031
PNG
(8-Methyl-2-[4-[(3-methyl-2- pyridyl)methyl]piperaz...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2C)CC1
Show InChI InChI=1S/C19H26N6O/c1-14-5-3-7-20-16(14)13-24-9-11-25(12-10-24)19-21-17-15(18(26)22-19)6-4-8-23(17)2/h3,5,7H,4,6,8-13H2,1-2H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318044
PNG
(US9624218, Example 45)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncc(F)cc2F)CC1
Show InChI InChI=1S/C18H22F2N6O/c1-24-4-2-3-13-16(24)22-18(23-17(13)27)26-7-5-25(6-8-26)11-15-14(20)9-12(19)10-21-15/h9-10H,2-8,11H2,1H3,(H,22,23,27)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318029
PNG
(2-[4-[(2- Fluorophenyl)methyl]piperazin-1- yl]-8-m...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccc2F)CC1
Show InChI InChI=1S/C19H24FN5O/c1-23-8-4-6-15-17(23)21-19(22-18(15)26)25-11-9-24(10-12-25)13-14-5-2-3-7-16(14)20/h2-3,5,7H,4,6,8-13H2,1H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318013
PNG
(8-Methyl-2-[4-(1-pyrimidin-2-ylethyl)piperazin-1-y...)
Show SMILES CC(N1CCN(CC1)c1nc2N(C)CCCc2c(=O)[nH]1)c1ncccn1
Show InChI InChI=1S/C18H25N7O/c1-13(15-19-6-4-7-20-15)24-9-11-25(12-10-24)18-21-16-14(17(26)22-18)5-3-8-23(16)2/h4,6-7,13H,3,5,8-12H2,1-2H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318022
PNG
(8-Methyl-2-[4-[[4-trifluoromethyl)pyrimidin-2- yl]...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2nccc(n2)C(F)(F)F)CC1
Show InChI InChI=1S/C18H22F3N7O/c1-26-6-2-3-12-15(26)24-17(25-16(12)29)28-9-7-27(8-10-28)11-14-22-5-4-13(23-14)18(19,20)21/h4-5H,2-3,6-11H2,1H3,(H,24,25,29)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318037
PNG
(2-[4-[(2-Chlorophenyl)methyl]piperazin-1-yl]-8-met...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccc2Cl)CC1
Show InChI InChI=1S/C19H24ClN5O/c1-23-8-4-6-15-17(23)21-19(22-18(15)26)25-11-9-24(10-12-25)13-14-5-2-3-7-16(14)20/h2-3,5,7H,4,6,8-13H2,1H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318025
PNG
(US9624218, Example 19 | US9624218, Example 34)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccn2)CC1
Show InChI InChI=1S/C18H24N6O/c1-22-8-4-6-15-16(22)20-18(21-17(15)25)24-11-9-23(10-12-24)13-14-5-2-3-7-19-14/h2-3,5,7H,4,6,8-13H2,1H3,(H,20,21,25)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318014
PNG
(8-Methyl-2-[4-(1-pyrimidin-2-ylethyl)piperazin-1-y...)
Show SMILES CC(N1CCN(CC1)c1nc2N(C)CCCc2c(=O)[nH]1)c1ncccn1
Show InChI InChI=1S/C18H25N7O/c1-13(15-19-6-4-7-20-15)24-9-11-25(12-10-24)18-21-16-14(17(26)22-18)5-3-8-23(16)2/h4,6-7,13H,3,5,8-12H2,1-2H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318022
PNG
(8-Methyl-2-[4-[[4-trifluoromethyl)pyrimidin-2- yl]...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2nccc(n2)C(F)(F)F)CC1
Show InChI InChI=1S/C18H22F3N7O/c1-26-6-2-3-12-15(26)24-17(25-16(12)29)28-9-7-27(8-10-28)11-14-22-5-4-13(23-14)18(19,20)21/h4-5H,2-3,6-11H2,1H3,(H,24,25,29)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318023
PNG
(8-Methyl-2-[4-[(5- methylpyrimidin-2- yl)methyl]pi...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncc(C)cn2)CC1
Show InChI InChI=1S/C18H25N7O/c1-13-10-19-15(20-11-13)12-24-6-8-25(9-7-24)18-21-16-14(17(26)22-18)4-3-5-23(16)2/h10-11H,3-9,12H2,1-2H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318014
PNG
(8-Methyl-2-[4-(1-pyrimidin-2-ylethyl)piperazin-1-y...)
Show SMILES CC(N1CCN(CC1)c1nc2N(C)CCCc2c(=O)[nH]1)c1ncccn1
Show InChI InChI=1S/C18H25N7O/c1-13(15-19-6-4-7-20-15)24-9-11-25(12-10-24)18-21-16-14(17(26)22-18)5-3-8-23(16)2/h4,6-7,13H,3,5,8-12H2,1-2H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318011
PNG
(US9624218, Example 5)
Show SMILES CC(N1CCN(CC1)c1nc2N(C)CCCc2c(=O)[nH]1)c1ncc(F)cn1
Show InChI InChI=1S/C18H24FN7O/c1-12(15-20-10-13(19)11-21-15)25-6-8-26(9-7-25)18-22-16-14(17(27)23-18)4-3-5-24(16)2/h10-12H,3-9H2,1-2H3,(H,22,23,27)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318023
PNG
(8-Methyl-2-[4-[(5- methylpyrimidin-2- yl)methyl]pi...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncc(C)cn2)CC1
Show InChI InChI=1S/C18H25N7O/c1-13-10-19-15(20-11-13)12-24-6-8-25(9-7-24)18-21-16-14(17(26)22-18)4-3-5-23(16)2/h10-11H,3-9,12H2,1-2H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318014
PNG
(8-Methyl-2-[4-(1-pyrimidin-2-ylethyl)piperazin-1-y...)
Show SMILES CC(N1CCN(CC1)c1nc2N(C)CCCc2c(=O)[nH]1)c1ncccn1
Show InChI InChI=1S/C18H25N7O/c1-13(15-19-6-4-7-20-15)24-9-11-25(12-10-24)18-21-16-14(17(26)22-18)5-3-8-23(16)2/h4,6-7,13H,3,5,8-12H2,1-2H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318024
PNG
(2-[4-[(5-Chloropyrimidin-2- yl)methyl]piperazin-1-...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncc(Cl)cn2)CC1
Show InChI InChI=1S/C17H22ClN7O/c1-23-4-2-3-13-15(23)21-17(22-16(13)26)25-7-5-24(6-8-25)11-14-19-9-12(18)10-20-14/h9-10H,2-8,11H2,1H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318011
PNG
(US9624218, Example 5)
Show SMILES CC(N1CCN(CC1)c1nc2N(C)CCCc2c(=O)[nH]1)c1ncc(F)cn1
Show InChI InChI=1S/C18H24FN7O/c1-12(15-20-10-13(19)11-21-15)25-6-8-26(9-7-25)18-22-16-14(17(27)23-18)4-3-5-24(16)2/h10-12H,3-9H2,1-2H3,(H,22,23,27)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318014
PNG
(8-Methyl-2-[4-(1-pyrimidin-2-ylethyl)piperazin-1-y...)
Show SMILES CC(N1CCN(CC1)c1nc2N(C)CCCc2c(=O)[nH]1)c1ncccn1
Show InChI InChI=1S/C18H25N7O/c1-13(15-19-6-4-7-20-15)24-9-11-25(12-10-24)18-21-16-14(17(26)22-18)5-3-8-23(16)2/h4,6-7,13H,3,5,8-12H2,1-2H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318024
PNG
(2-[4-[(5-Chloropyrimidin-2- yl)methyl]piperazin-1-...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncc(Cl)cn2)CC1
Show InChI InChI=1S/C17H22ClN7O/c1-23-4-2-3-13-15(23)21-17(22-16(13)26)25-7-5-24(6-8-25)11-14-19-9-12(18)10-20-14/h9-10H,2-8,11H2,1H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)


(Homo sapiens (Human))
BDBM318016
PNG
(8-Methyl-2-[4-(1-pyrimidin-2-ylpropyl)piperazin-1-...)
Show SMILES CCC(N1CCN(CC1)c1nc2N(C)CCCc2c(=O)[nH]1)c1ncccn1
Show InChI InChI=1S/C19H27N7O/c1-3-15(16-20-7-5-8-21-16)25-10-12-26(13-11-25)19-22-17-14(18(27)23-19)6-4-9-24(17)2/h5,7-8,15H,3-4,6,9-13H2,1-2H3,(H,22,23,27)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Tankyrase 1 (TNKS1)


(Homo sapiens (Human))
BDBM318016
PNG
(8-Methyl-2-[4-(1-pyrimidin-2-ylpropyl)piperazin-1-...)
Show SMILES CCC(N1CCN(CC1)c1nc2N(C)CCCc2c(=O)[nH]1)c1ncccn1
Show InChI InChI=1S/C19H27N7O/c1-3-15(16-20-7-5-8-21-16)25-10-12-26(13-11-25)19-22-17-14(18(27)23-19)6-4-9-24(17)2/h5,7-8,15H,3-4,6,9-13H2,1-2H3,(H,22,23,27)
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Eli Lilly and Company

US Patent


Assay Description
The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318022
PNG
(8-Methyl-2-[4-[[4-trifluoromethyl)pyrimidin-2- yl]...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2nccc(n2)C(F)(F)F)CC1
Show InChI InChI=1S/C18H22F3N7O/c1-26-6-2-3-12-15(26)24-17(25-16(12)29)28-9-7-27(8-10-28)11-14-22-5-4-13(23-14)18(19,20)21/h4-5H,2-3,6-11H2,1H3,(H,24,25,29)
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Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318008
PNG
(2-[4-[(3-Chloro-2-pyridyl)methyl]piperazin-1-yl]-8...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2Cl)CC1
Show InChI InChI=1S/C18H23ClN6O/c1-23-7-3-4-13-16(23)21-18(22-17(13)26)25-10-8-24(9-11-25)12-15-14(19)5-2-6-20-15/h2,5-6H,3-4,7-12H2,1H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318009
PNG
(2-[4-[(3-Bromo-2- pyridyl)methyl]piperazin-1- yl]-...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2Br)CC1
Show InChI InChI=1S/C18H23BrN6O/c1-23-7-3-4-13-16(23)21-18(22-17(13)26)25-10-8-24(9-11-25)12-15-14(19)5-2-6-20-15/h2,5-6H,3-4,7-12H2,1H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318036
PNG
(2-[[4-(8-Methyl-4-oxo-3,5,6,7-tetrahydropyrido[2,3...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccc2C#N)CC1
Show InChI InChI=1S/C20H24N6O/c1-24-8-4-7-17-18(24)22-20(23-19(17)27)26-11-9-25(10-12-26)14-16-6-3-2-5-15(16)13-21/h2-3,5-6H,4,7-12,14H2,1H3,(H,22,23,27)
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Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318041
PNG
(8-Methyl-2-[4-(pyrazin-2-ylmethyl)piperazin-1-yl]-...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2cnccn2)CC1
Show InChI InChI=1S/C17H23N7O/c1-22-6-2-3-14-15(22)20-17(21-16(14)25)24-9-7-23(8-10-24)12-13-11-18-4-5-19-13/h4-5,11H,2-3,6-10,12H2,1H3,(H,20,21,25)
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Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318007
PNG
(8-Methyl-2-[4-(pyrimidin-2-ylmethyl)piperazin-1-yl...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccn2)CC1
Show InChI InChI=1S/C17H23N7O/c1-22-7-2-4-13-15(22)20-17(21-16(13)25)24-10-8-23(9-11-24)12-14-18-5-3-6-19-14/h3,5-6H,2,4,7-12H2,1H3,(H,20,21,25)
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Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318039
PNG
(2-[[4-(8-Methyl-4-oxo-3,5,6,7-tetrahydropyrido[2,3...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2C#N)CC1
Show InChI InChI=1S/C19H23N7O/c1-24-7-3-5-15-17(24)22-19(23-18(15)27)26-10-8-25(9-11-26)13-16-14(12-20)4-2-6-21-16/h2,4,6H,3,5,7-11,13H2,1H3,(H,22,23,27)
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Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318010
PNG
(2-[4-[(3-Hydroxy-2- pyridyl)methyl]piperazin-1- yl...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2O)CC1
Show InChI InChI=1S/C18H24N6O2/c1-22-7-3-4-13-16(22)20-18(21-17(13)26)24-10-8-23(9-11-24)12-14-15(25)5-2-6-19-14/h2,5-6,25H,3-4,7-12H2,1H3,(H,20,21,26)
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Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318019
PNG
(2-[4-[(4-methoxypyrimidin-2-yl)methyl]piperazin-1-...)
Show SMILES COc1ccnc(CN2CCN(CC2)c2nc3N(C)CCCc3c(=O)[nH]2)n1
Show InChI InChI=1S/C18H25N7O2/c1-23-7-3-4-13-16(23)21-18(22-17(13)26)25-10-8-24(9-11-25)12-14-19-6-5-15(20-14)27-2/h5-6H,3-4,7-12H2,1-2H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318044
PNG
(US9624218, Example 45)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncc(F)cc2F)CC1
Show InChI InChI=1S/C18H22F2N6O/c1-24-4-2-3-13-16(24)22-18(23-17(13)27)26-7-5-25(6-8-26)11-15-14(20)9-12(19)10-21-15/h9-10H,2-8,11H2,1H3,(H,22,23,27)
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Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318014
PNG
(8-Methyl-2-[4-(1-pyrimidin-2-ylethyl)piperazin-1-y...)
Show SMILES CC(N1CCN(CC1)c1nc2N(C)CCCc2c(=O)[nH]1)c1ncccn1
Show InChI InChI=1S/C18H25N7O/c1-13(15-19-6-4-7-20-15)24-9-11-25(12-10-24)18-21-16-14(17(26)22-18)5-3-8-23(16)2/h4,6-7,13H,3,5,8-12H2,1-2H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318007
PNG
(8-Methyl-2-[4-(pyrimidin-2-ylmethyl)piperazin-1-yl...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccn2)CC1
Show InChI InChI=1S/C17H23N7O/c1-22-7-2-4-13-15(22)20-17(21-16(13)25)24-10-8-23(9-11-24)12-14-18-5-3-6-19-14/h3,5-6H,2,4,7-12H2,1H3,(H,20,21,25)
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Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318040
PNG
(2-[4-[(4-Chloropyrimidin-2-yl)methyl]piperazin-1-y...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2nccc(Cl)n2)CC1
Show InChI InChI=1S/C17H22ClN7O/c1-23-6-2-3-12-15(23)21-17(22-16(12)26)25-9-7-24(8-10-25)11-14-19-5-4-13(18)20-14/h4-5H,2-3,6-11H2,1H3,(H,21,22,26)
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n/an/a 4.66E+3n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318017
PNG
(8-Methyl-2-[4-(1-pyrimidin-2-ylpropyl)piperazin-1-...)
Show SMILES CCC(N1CCN(CC1)c1nc2N(C)CCCc2c(=O)[nH]1)c1ncccn1
Show InChI InChI=1S/C19H27N7O/c1-3-15(16-20-7-5-8-21-16)25-10-12-26(13-11-25)19-22-17-14(18(27)23-19)6-4-9-24(17)2/h5,7-8,15H,3-4,6,9-13H2,1-2H3,(H,22,23,27)
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Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318025
PNG
(US9624218, Example 19 | US9624218, Example 34)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccn2)CC1
Show InChI InChI=1S/C18H24N6O/c1-22-8-4-6-15-16(22)20-18(21-17(15)25)24-11-9-23(10-12-24)13-14-5-2-3-7-19-14/h2-3,5,7H,4,6,8-13H2,1H3,(H,20,21,25)
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Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318014
PNG
(8-Methyl-2-[4-(1-pyrimidin-2-ylethyl)piperazin-1-y...)
Show SMILES CC(N1CCN(CC1)c1nc2N(C)CCCc2c(=O)[nH]1)c1ncccn1
Show InChI InChI=1S/C18H25N7O/c1-13(15-19-6-4-7-20-15)24-9-11-25(12-10-24)18-21-16-14(17(26)22-18)5-3-8-23(16)2/h4,6-7,13H,3,5,8-12H2,1-2H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318020
PNG
(8-Methyl-2-[4-[(4- methylpyrimidin-2- yl)methyl]pi...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2nccc(C)n2)CC1
Show InChI InChI=1S/C18H25N7O/c1-13-5-6-19-15(20-13)12-24-8-10-25(11-9-24)18-21-16-14(17(26)22-18)4-3-7-23(16)2/h5-6H,3-4,7-12H2,1-2H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318043
PNG
(8-Methyl-2-[4-[(3-methyl- pyrazin-2-yl)methyl]pipe...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2nccnc2C)CC1
Show InChI InChI=1S/C18H25N7O/c1-13-15(20-6-5-19-13)12-24-8-10-25(11-9-24)18-21-16-14(17(26)22-18)4-3-7-23(16)2/h5-6H,3-4,7-12H2,1-2H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318013
PNG
(8-Methyl-2-[4-(1-pyrimidin-2-ylethyl)piperazin-1-y...)
Show SMILES CC(N1CCN(CC1)c1nc2N(C)CCCc2c(=O)[nH]1)c1ncccn1
Show InChI InChI=1S/C18H25N7O/c1-13(15-19-6-4-7-20-15)24-9-11-25(12-10-24)18-21-16-14(17(26)22-18)5-3-8-23(16)2/h4,6-7,13H,3,5,8-12H2,1-2H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318028
PNG
(2-[4-[(2- Methoxyphenyl)methyl]piperazin- 1-yl]-8-...)
Show SMILES COc1ccccc1CN1CCN(CC1)c1nc2N(C)CCCc2c(=O)[nH]1
Show InChI InChI=1S/C20H27N5O2/c1-23-9-5-7-16-18(23)21-20(22-19(16)26)25-12-10-24(11-13-25)14-15-6-3-4-8-17(15)27-2/h3-4,6,8H,5,7,9-14H2,1-2H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318042
PNG
(2-[4-[(3-Chloropyrazin-2- yl)methyl]piperazin-l-yl...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2nccnc2Cl)CC1
Show InChI InChI=1S/C17H22ClN7O/c1-23-6-2-3-12-15(23)21-17(22-16(12)26)25-9-7-24(8-10-25)11-13-14(18)20-5-4-19-13/h4-5H,2-3,6-11H2,1H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318021
PNG
(8-Methyl-2-[4-[[5-trifluoromethyl)pyrimidin-2- yl]...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncc(cn2)C(F)(F)F)CC1
Show InChI InChI=1S/C18H22F3N7O/c1-26-4-2-3-13-15(26)24-17(25-16(13)29)28-7-5-27(6-8-28)11-14-22-9-12(10-23-14)18(19,20)21/h9-10H,2-8,11H2,1H3,(H,24,25,29)
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n/an/a 6.91E+3n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318023
PNG
(8-Methyl-2-[4-[(5- methylpyrimidin-2- yl)methyl]pi...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncc(C)cn2)CC1
Show InChI InChI=1S/C18H25N7O/c1-13-10-19-15(20-11-13)12-24-6-8-25(9-7-24)18-21-16-14(17(26)22-18)4-3-5-23(16)2/h10-11H,3-9,12H2,1-2H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318011
PNG
(US9624218, Example 5)
Show SMILES CC(N1CCN(CC1)c1nc2N(C)CCCc2c(=O)[nH]1)c1ncc(F)cn1
Show InChI InChI=1S/C18H24FN7O/c1-12(15-20-10-13(19)11-21-15)25-6-8-26(9-7-25)18-22-16-14(17(27)23-18)4-3-5-24(16)2/h10-12H,3-9H2,1-2H3,(H,22,23,27)
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Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318038
PNG
(2-[4-[(5-Fluoropyrimidin-2-yl)methyl]piperazin-1-y...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncc(F)cn2)CC1
Show InChI InChI=1S/C17H22FN7O/c1-23-4-2-3-13-15(23)21-17(22-16(13)26)25-7-5-24(6-8-25)11-14-19-9-12(18)10-20-14/h9-10H,2-8,11H2,1H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318026
PNG
(2-[4-[(3-Fluoro-2-pyridyl)methyl]piperazin-1-yl]-8...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2F)CC1
Show InChI InChI=1S/C18H23FN6O/c1-23-7-3-4-13-16(23)21-18(22-17(13)26)25-10-8-24(9-11-25)12-15-14(19)5-2-6-20-15/h2,5-6H,3-4,7-12H2,1H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318029
PNG
(2-[4-[(2- Fluorophenyl)methyl]piperazin-1- yl]-8-m...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccc2F)CC1
Show InChI InChI=1S/C19H24FN5O/c1-23-8-4-6-15-17(23)21-19(22-18(15)26)25-11-9-24(10-12-25)13-14-5-2-3-7-16(14)20/h2-3,5,7H,4,6,8-13H2,1H3,(H,21,22,26)
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n/an/a 8.80E+3n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318017
PNG
(8-Methyl-2-[4-(1-pyrimidin-2-ylpropyl)piperazin-1-...)
Show SMILES CCC(N1CCN(CC1)c1nc2N(C)CCCc2c(=O)[nH]1)c1ncccn1
Show InChI InChI=1S/C19H27N7O/c1-3-15(16-20-7-5-8-21-16)25-10-12-26(13-11-25)19-22-17-14(18(27)23-19)6-4-9-24(17)2/h5,7-8,15H,3-4,6,9-13H2,1-2H3,(H,22,23,27)
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n/an/a 1.35E+4n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318032
PNG
(2-[4-[(3-Methoxy-2- pyridyl)methyl]piperazin-1-yl]...)
Show SMILES COc1cccnc1CN1CCN(CC1)c1nc2N(C)CCCc2c(=O)[nH]1
Show InChI InChI=1S/C19H26N6O2/c1-23-8-4-5-14-17(23)21-19(22-18(14)26)25-11-9-24(10-12-25)13-15-16(27-2)6-3-7-20-15/h3,6-7H,4-5,8-13H2,1-2H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318025
PNG
(US9624218, Example 19 | US9624218, Example 34)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccn2)CC1
Show InChI InChI=1S/C18H24N6O/c1-22-8-4-6-15-16(22)20-18(21-17(15)25)24-11-9-23(10-12-24)13-14-5-2-3-7-19-14/h2-3,5,7H,4,6,8-13H2,1H3,(H,20,21,25)
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Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318030
PNG
(8-Methyl-2-[4-(o- tolylmethyl)piperazin-1-yl]- 3,5...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccc2C)CC1
Show InChI InChI=1S/C20H27N5O/c1-15-6-3-4-7-16(15)14-24-10-12-25(13-11-24)20-21-18-17(19(26)22-20)8-5-9-23(18)2/h3-4,6-7H,5,8-14H2,1-2H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318031
PNG
(8-Methyl-2-[4-[(3-methyl-2- pyridyl)methyl]piperaz...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2C)CC1
Show InChI InChI=1S/C19H26N6O/c1-14-5-3-7-20-16(14)13-24-9-11-25(12-10-24)19-21-17-15(18(26)22-19)6-4-8-23(17)2/h3,5,7H,4,6,8-13H2,1-2H3,(H,21,22,26)
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Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318016
PNG
(8-Methyl-2-[4-(1-pyrimidin-2-ylpropyl)piperazin-1-...)
Show SMILES CCC(N1CCN(CC1)c1nc2N(C)CCCc2c(=O)[nH]1)c1ncccn1
Show InChI InChI=1S/C19H27N7O/c1-3-15(16-20-7-5-8-21-16)25-10-12-26(13-11-25)19-22-17-14(18(27)23-19)6-4-9-24(17)2/h5,7-8,15H,3-4,6,9-13H2,1-2H3,(H,22,23,27)
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n/an/a 3.37E+4n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318037
PNG
(2-[4-[(2-Chlorophenyl)methyl]piperazin-1-yl]-8-met...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccc2Cl)CC1
Show InChI InChI=1S/C19H24ClN5O/c1-23-8-4-6-15-17(23)21-19(22-18(15)26)25-11-9-24(10-12-25)13-14-5-2-3-7-16(14)20/h2-3,5,7H,4,6,8-13H2,1H3,(H,21,22,26)
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US Patent
n/an/a 4.67E+4n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318024
PNG
(2-[4-[(5-Chloropyrimidin-2- yl)methyl]piperazin-1-...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncc(Cl)cn2)CC1
Show InChI InChI=1S/C17H22ClN7O/c1-23-4-2-3-13-15(23)21-17(22-16(13)26)25-7-5-24(6-8-25)11-14-19-9-12(18)10-20-14/h9-10H,2-8,11H2,1H3,(H,21,22,26)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7.76E+4n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM318034
PNG
(8-Methyl-2-[4-[[3-trifluoromethyl)-2- pyridyl]meth...)
Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccc2C(F)(F)F)CC1
Show InChI InChI=1S/C20H24F3N5O/c1-26-8-4-6-15-17(26)24-19(25-18(15)29)28-11-9-27(10-12-28)13-14-5-2-3-7-16(14)20(21,22)23/h2-3,5,7H,4,6,8-13H2,1H3,(H,24,25,29)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 9.57E+4n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...


US Patent US9624218 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%