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Patent code US9624228

Compile Data Set for Download or QSAR

Found 377 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318291
PNG
(US9624228, Example 248 | US9624228, Example 308)
Show SMILES CN1C[C@H]([C@@H](C1)c1ccccc1)N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1cc(C)nc(C)c1
Show InChI InChI=1S/C27H28N6O/c1-16-9-19(10-17(2)28-16)26-21-11-20-13-33(27(34)29-23(20)12-24(21)30-31-26)25-15-32(3)14-22(25)18-7-5-4-6-8-18/h4-12,22,25H,13-15H2,1-3H3,(H,29,34)(H,30,31)/t22-,25+/m0/s1
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318353
PNG
(US9624228, Example 310)
Show SMILES Cc1cc(cc(C)n1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@H]1CCN(CC(F)(F)F)C1
Show InChI InChI=1S/C22H23F3N6O/c1-12-5-14(6-13(2)26-12)20-17-7-15-9-31(16-3-4-30(10-16)11-22(23,24)25)21(32)27-18(15)8-19(17)28-29-20/h5-8,16H,3-4,9-11H2,1-2H3,(H,27,32)(H,28,29)/t16-/m0/s1
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318395
PNG
(US9624228, Example 353)
Show SMILES COc1ccc(cn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CN(C)C[C@H]1c1ccccc1
Show InChI InChI=1S/C26H26N6O2/c1-31-14-20(16-6-4-3-5-7-16)23(15-31)32-13-18-10-19-22(11-21(18)28-26(32)33)29-30-25(19)17-8-9-24(34-2)27-12-17/h3-12,20,23H,13-15H2,1-2H3,(H,28,33)(H,29,30)/t20-,23+/m0/s1
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318412
PNG
(US9624228, Example 370)
Show SMILES COc1cc(ccn1)-c1n[nH]c2cc3[nH]c(=O)c(cc3cc12)C1CCCN(Cc2ccccc2)C1
Show InChI InChI=1S/C28H25N5O2/c1-35-26-14-19(9-10-29-26)27-23-13-21-12-22(28(34)30-24(21)15-25(23)31-32-27)20-8-5-11-33(17-20)16-18-6-3-2-4-7-18/h2-4,6-7,9-10,12-15,20H,5,8,11,16-17H2,1H3
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318418
PNG
(US9624228, Example 376)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CN(CCO)C[C@H]1c1ccccc1
Show InChI InChI=1S/C27H28N6O2/c1-17-11-19(7-8-28-17)26-21-12-20-14-33(27(35)29-23(20)13-24(21)30-31-26)25-16-32(9-10-34)15-22(25)18-5-3-2-4-6-18/h2-8,11-13,22,25,34H,9-10,14-16H2,1H3,(H,29,35)(H,30,31)/t22-,25+/m0/s1
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318421
PNG
(US9624228, Example 379)
Show SMILES Cc1cc(cc(C)n1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CN(CC(F)F)C[C@H]1c1ccccc1
Show InChI InChI=1S/C28H28F2N6O/c1-16-8-19(9-17(2)31-16)27-21-10-20-12-36(28(37)32-23(20)11-24(21)33-34-27)25-14-35(15-26(29)30)13-22(25)18-6-4-3-5-7-18/h3-11,22,25-26H,12-15H2,1-2H3,(H,32,37)(H,33,34)/t22-,25+/m0/s1
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318159
PNG
(US9624228, Example 115)
Show SMILES C[C@@H](N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnnc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H17ClN6O/c1-12(13-2-4-16(22)5-3-13)28-11-15-8-17-19(9-18(15)25-21(28)29)26-27-20(17)14-6-7-23-24-10-14/h2-10,12H,11H2,1H3,(H,25,29)(H,26,27)/t12-/m1/s1
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318170
PNG
(US9624228, Example 126)
Show SMILES COc1cccc(F)c1CN1CCC[C@H](C1)N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnnc1
Show InChI InChI=1S/C26H26FN7O2/c1-36-24-6-2-5-21(27)20(24)15-33-9-3-4-18(14-33)34-13-17-10-19-23(11-22(17)30-26(34)35)31-32-25(19)16-7-8-28-29-12-16/h2,5-8,10-12,18H,3-4,9,13-15H2,1H3,(H,30,35)(H,31,32)/t18-/m1/s1
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318172
PNG
(US9624228, Example 128)
Show SMILES O=C1Nc2cc3[nH]nc(-c4ccnnc4)c3cc2CN1Cc1cccc(c1)C#N
Show InChI InChI=1S/C21H15N7O/c22-9-13-2-1-3-14(6-13)11-28-12-16-7-17-19(8-18(16)25-21(28)29)26-27-20(17)15-4-5-23-24-10-15/h1-8,10H,11-12H2,(H,25,29)(H,26,27)
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318178
PNG
(US9624228, Example 134)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(Cc2ccc(F)c(Cl)c2)C1
Show InChI InChI=1S/C27H26ClFN6O/c1-16-9-18(6-7-30-16)26-21-11-19-14-35(27(36)31-24(19)12-25(21)32-33-26)20-3-2-8-34(15-20)13-17-4-5-23(29)22(28)10-17/h4-7,9-12,20H,2-3,8,13-15H2,1H3,(H,31,36)(H,32,33)/t20-/m1/s1
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318208
PNG
(US9624228, Example 164)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(CCc2cccc(Cl)c2)C1
Show InChI InChI=1S/C28H29ClN6O/c1-18-12-20(7-9-30-18)27-24-14-21-16-35(28(36)31-25(21)15-26(24)32-33-27)23-6-3-10-34(17-23)11-8-19-4-2-5-22(29)13-19/h2,4-5,7,9,12-15,23H,3,6,8,10-11,16-17H2,1H3,(H,31,36)(H,32,33)/t23-/m1/s1
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM272554
PNG
(US10065967, Example 20 | US9624228, Example 2)
Show SMILES C[C@@H](N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnc(C)c1)c1ccccc1
Show InChI InChI=1S/C23H21N5O/c1-14-10-17(8-9-24-14)22-19-11-18-13-28(15(2)16-6-4-3-5-7-16)23(29)25-20(18)12-21(19)26-27-22/h3-12,15H,13H2,1-2H3,(H,25,29)(H,26,27)/t15-/m1/s1
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318057
PNG
(US9624228, Example 13)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc4ccc(F)c(F)c4)Cc3cc12
Show InChI InChI=1S/C22H17F2N5O/c1-12-6-14(4-5-25-12)21-16-8-15-11-29(10-13-2-3-17(23)18(24)7-13)22(30)26-19(15)9-20(16)27-28-21/h2-9H,10-11H2,1H3,(H,26,30)(H,27,28)
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318071
PNG
(US9624228, Example 27)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3[nH]c(=O)n(Cc4ccccc4)c(=O)c3cc12
Show InChI InChI=1S/C22H15N5O2/c1-13-9-15(7-8-23-13)20-16-10-17-18(11-19(16)25-26-20)24-22(29)27(21(17)28)12-14-5-3-2-4-6-14/h2-11H,12H2,1H3
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318083
PNG
(US9624228, Example 39)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc4ccc(cc4)C#N)Cc3cc12
Show InChI InChI=1S/C23H18N6O/c1-14-8-17(6-7-25-14)22-19-9-18-13-29(12-16-4-2-15(11-24)3-5-16)23(30)26-20(18)10-21(19)27-28-22/h2-10H,12-13H2,1H3,(H,26,30)(H,27,28)
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318096
PNG
(US9624228, Example 52)
Show SMILES COCCN1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnc(C)c1
Show InChI InChI=1S/C18H19N5O2/c1-11-7-12(3-4-19-11)17-14-8-13-10-23(5-6-25-2)18(24)20-15(13)9-16(14)21-22-17/h3-4,7-9H,5-6,10H2,1-2H3,(H,20,24)(H,21,22)
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318098
PNG
(US9624228, Example 54)
Show SMILES C[C@H](CO)N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnc(C)c1
Show InChI InChI=1S/C18H19N5O2/c1-10-5-12(3-4-19-10)17-14-6-13-8-23(11(2)9-24)18(25)20-15(13)7-16(14)21-22-17/h3-7,11,24H,8-9H2,1-2H3,(H,20,25)(H,21,22)/t11-/m1/s1
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318103
PNG
(US9624228, Example 59)
Show SMILES Clc1cccc(CN2Cc3cc4c(n[nH]c4cc3NC2=O)-c2ccc3nncn3c2)c1
Show InChI InChI=1S/C22H16ClN7O/c23-16-3-1-2-13(6-16)9-29-11-15-7-17-19(8-18(15)25-22(29)31)26-28-21(17)14-4-5-20-27-24-12-30(20)10-14/h1-8,10,12H,9,11H2,(H,25,31)(H,26,28)
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318121
PNG
(US9624228, Example 77)
Show SMILES Cc1cc(cc(C)n1)-c1n[nH]c2cc3NC(=O)N(Cc4cccc(Cl)c4)Cc3cc12
Show InChI InChI=1S/C23H20ClN5O/c1-13-6-16(7-14(2)25-13)22-19-9-17-12-29(11-15-4-3-5-18(24)8-15)23(30)26-20(17)10-21(19)27-28-22/h3-10H,11-12H2,1-2H3,(H,26,30)(H,27,28)
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318124
PNG
(US9624228, Example 80)
Show SMILES COc1ncc(cn1)-c1n[nH]c2cc3NC(=O)N(CCc4ccc(F)cc4)Cc3cc12
Show InChI InChI=1S/C22H19FN6O2/c1-31-21-24-10-15(11-25-21)20-17-8-14-12-29(7-6-13-2-4-16(23)5-3-13)22(30)26-18(14)9-19(17)27-28-20/h2-5,8-11H,6-7,12H2,1H3,(H,26,30)(H,27,28)
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318134
PNG
(US9624228, Example 90)
Show SMILES Cc1ncc(cn1)-c1n[nH]c2cc3NC(=O)N(Cc4cccc(Cl)c4)Cc3cc12
Show InChI InChI=1S/C21H17ClN6O/c1-12-23-8-15(9-24-12)20-17-6-14-11-28(10-13-3-2-4-16(22)5-13)21(29)25-18(14)7-19(17)26-27-20/h2-9H,10-11H2,1H3,(H,25,29)(H,26,27)
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318145
PNG
(US9624228, Example 101)
Show SMILES COc1ncc(cn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(Cc2ccccc2F)C1
Show InChI InChI=1S/C26H26FN7O2/c1-36-25-28-11-18(12-29-25)24-20-9-17-14-34(26(35)30-22(17)10-23(20)31-32-24)19-6-4-8-33(15-19)13-16-5-2-3-7-21(16)27/h2-3,5,7,9-12,19H,4,6,8,13-15H2,1H3,(H,30,35)(H,31,32)/t19-/m1/s1
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318147
PNG
(US9624228, Example 103)
Show SMILES COc1cccc(F)c1CN1CCC[C@H](C1)N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1cnc(OC)nc1
Show InChI InChI=1S/C27H28FN7O3/c1-37-24-7-3-6-21(28)20(24)15-34-8-4-5-18(14-34)35-13-16-9-19-23(10-22(16)31-27(35)36)32-33-25(19)17-11-29-26(38-2)30-12-17/h3,6-7,9-12,18H,4-5,8,13-15H2,1-2H3,(H,31,36)(H,32,33)/t18-/m1/s1
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318149
PNG
(US9624228, Example 105)
Show SMILES CCC(=O)NCCCN1Cc2cc3c(n[nH]c3cc2NC1=O)-c1cnc(OC)nc1
Show InChI InChI=1S/C20H23N7O3/c1-3-17(28)21-5-4-6-27-11-12-7-14-16(8-15(12)24-20(27)29)25-26-18(14)13-9-22-19(30-2)23-10-13/h7-10H,3-6,11H2,1-2H3,(H,21,28)(H,24,29)(H,25,26)
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318155
PNG
(US9624228, Example 111)
Show SMILES C[C@@H](N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnnc1)c1cccc(Cl)c1
Show InChI InChI=1S/C21H17ClN6O/c1-12(13-3-2-4-16(22)7-13)28-11-15-8-17-19(9-18(15)25-21(28)29)26-27-20(17)14-5-6-23-24-10-14/h2-10,12H,11H2,1H3,(H,25,29)(H,26,27)/t12-/m1/s1
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318219
PNG
(US9624228, Example 175)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(CCNCc4ccc(F)cc4)Cc3cc12
Show InChI InChI=1S/C24H23FN6O/c1-15-10-17(6-7-27-15)23-20-11-18-14-31(24(32)28-21(18)12-22(20)29-30-23)9-8-26-13-16-2-4-19(25)5-3-16/h2-7,10-12,26H,8-9,13-14H2,1H3,(H,28,32)(H,29,30)
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318240
PNG
(US9624228, Example 196)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(Cc2ccc(F)cc2F)C1
Show InChI InChI=1S/C27H26F2N6O/c1-16-9-17(6-7-30-16)26-22-10-19-14-35(27(36)31-24(19)12-25(22)32-33-26)21-3-2-8-34(15-21)13-18-4-5-20(28)11-23(18)29/h4-7,9-12,21H,2-3,8,13-15H2,1H3,(H,31,36)(H,32,33)/t21-/m1/s1
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318243
PNG
(US9624228, Example 199)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(C1)c1ccc(F)cn1
Show InChI InChI=1S/C25H24FN7O/c1-15-9-16(6-7-27-15)24-20-10-17-13-33(25(34)29-21(17)11-22(20)30-31-24)19-3-2-8-32(14-19)23-5-4-18(26)12-28-23/h4-7,9-12,19H,2-3,8,13-14H2,1H3,(H,29,34)(H,30,31)/t19-/m1/s1
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318249
PNG
(US9624228, Example 205)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)C1CCCC1
Show InChI InChI=1S/C20H21N5O/c1-12-8-13(6-7-21-12)19-16-9-14-11-25(15-4-2-3-5-15)20(26)22-17(14)10-18(16)23-24-19/h6-10,15H,2-5,11H2,1H3,(H,22,26)(H,23,24)
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318262
PNG
(US9624228, Example 218)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc4ccccc4C(F)(F)F)Cc3cc12
Show InChI InChI=1S/C23H18F3N5O/c1-13-8-14(6-7-27-13)21-17-9-16-12-31(22(32)28-19(16)10-20(17)29-30-21)11-15-4-2-3-5-18(15)23(24,25)26/h2-10H,11-12H2,1H3,(H,28,32)(H,29,30)
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318263
PNG
(US9624228, Example 219)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)C1CCOC(C)(C)C1
Show InChI InChI=1S/C22H25N5O2/c1-13-8-14(4-6-23-13)20-17-9-15-12-27(16-5-7-29-22(2,3)11-16)21(28)24-18(15)10-19(17)25-26-20/h4,6,8-10,16H,5,7,11-12H2,1-3H3,(H,24,28)(H,25,26)
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318275
PNG
(US9624228, Example 232)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)C1CCC(=O)N(Cc2ccccc2)C1
Show InChI InChI=1S/C27H26N6O2/c1-17-11-19(9-10-28-17)26-22-12-20-15-33(27(35)29-23(20)13-24(22)30-31-26)21-7-8-25(34)32(16-21)14-18-5-3-2-4-6-18/h2-6,9-13,21H,7-8,14-16H2,1H3,(H,29,35)(H,30,31)
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318277
PNG
(US9624228, Example 234)
Show SMILES CC(N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnc(C)c1)c1nccs1
Show InChI InChI=1S/C20H18N6OS/c1-11-7-13(3-4-21-11)18-15-8-14-10-26(12(2)19-22-5-6-28-19)20(27)23-16(14)9-17(15)24-25-18/h3-9,12H,10H2,1-2H3,(H,23,27)(H,24,25)
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318286
PNG
(US9624228, Example 243)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)C1CCC1
Show InChI InChI=1S/C19H19N5O/c1-11-7-12(5-6-20-11)18-15-8-13-10-24(14-3-2-4-14)19(25)21-16(13)9-17(15)22-23-18/h5-9,14H,2-4,10H2,1H3,(H,21,25)(H,22,23)
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318290
PNG
(US9624228, Example 247)
Show SMILES CC(C)N1CCC[C@H](C1)N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnc(C)c1
Show InChI InChI=1S/C23H28N6O/c1-14(2)28-8-4-5-18(13-28)29-12-17-10-19-21(11-20(17)25-23(29)30)26-27-22(19)16-6-7-24-15(3)9-16/h6-7,9-11,14,18H,4-5,8,12-13H2,1-3H3,(H,25,30)(H,26,27)/t18-/m1/s1
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318295
PNG
(US9624228, Example 252)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(Cc2ccsc2)C1
Show InChI InChI=1S/C25H26N6OS/c1-16-9-18(4-6-26-16)24-21-10-19-13-31(25(32)27-22(19)11-23(21)28-29-24)20-3-2-7-30(14-20)12-17-5-8-33-15-17/h4-6,8-11,15,20H,2-3,7,12-14H2,1H3,(H,27,32)(H,28,29)/t20-/m1/s1
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318302
PNG
(US9624228, Example 259)
Show SMILES Cn1cc(cn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCN(CC(F)(F)F)C1
Show InChI InChI=1S/C19H20F3N7O/c1-27-7-12(6-23-27)17-14-4-11-8-29(13-2-3-28(9-13)10-19(20,21)22)18(30)24-15(11)5-16(14)25-26-17/h4-7,13H,2-3,8-10H2,1H3,(H,24,30)(H,25,26)/t13-/m1/s1
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318309
PNG
(US9624228, Example 266)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3[nH]c(=O)c(CC4CCCCC4)cc3cc12
Show InChI InChI=1S/C23H22N4O/c1-14-9-16(7-8-24-14)22-19-12-17-11-18(10-15-5-3-2-4-6-15)23(28)25-20(17)13-21(19)26-27-22/h7-9,11-13,15H,2-6,10H2,1H3
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318338
PNG
(US9624228, Example 295)
Show SMILES COc1ncc(cn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(Cc2cccs2)C1
Show InChI InChI=1S/C24H25N7O2S/c1-33-23-25-10-16(11-26-23)22-19-8-15-12-31(24(32)27-20(15)9-21(19)28-29-22)17-4-2-6-30(13-17)14-18-5-3-7-34-18/h3,5,7-11,17H,2,4,6,12-14H2,1H3,(H,27,32)(H,28,29)/t17-/m1/s1
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318378
PNG
(US9624228, Example 335)
Show SMILES CC(c1ccccc1)c1cc2cc3c(n[nH]c3cc2[nH]c1=O)-c1cccnc1C
Show InChI InChI=1S/C24H18N4O/c1-14(16-7-4-3-5-8-16)19-11-17-12-20-22(13-21(17)26-24(19)29)27-28-23(20)18-9-6-10-25-15(18)2/h3-14H,1-2H3
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318396
PNG
(US9624228, Example 354)
Show SMILES COc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CN(C)C[C@H]1c1ccccc1
Show InChI InChI=1S/C26H26N6O2/c1-31-14-20(16-6-4-3-5-7-16)23(15-31)32-13-18-10-19-22(12-21(18)28-26(32)33)29-30-25(19)17-8-9-27-24(11-17)34-2/h3-12,20,23H,13-15H2,1-2H3,(H,28,33)(H,29,30)/t20-,23+/m0/s1
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318398
PNG
(US9624228, Example 356)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CN(CCC#N)C[C@H]1c1ccccc1
Show InChI InChI=1S/C28H27N7O/c1-18-12-20(8-10-30-18)27-22-13-21-15-35(28(36)31-24(21)14-25(22)32-33-27)26-17-34(11-5-9-29)16-23(26)19-6-3-2-4-7-19/h2-4,6-8,10,12-14,23,26H,5,11,15-17H2,1H3,(H,31,36)(H,32,33)/t23-,26+/m0/s1
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318216
PNG
(US9624228, Example 172)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(C1)C(=O)c1ccccc1
Show InChI InChI=1S/C27H26N6O2/c1-17-12-19(9-10-28-17)25-22-13-20-15-33(27(35)29-23(20)14-24(22)30-31-25)21-8-5-11-32(16-21)26(34)18-6-3-2-4-7-18/h2-4,6-7,9-10,12-14,21H,5,8,11,15-16H2,1H3,(H,29,35)(H,30,31)/t21-/m1/s1
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318163
PNG
(US9624228, Example 119)
Show SMILES COc1ncc(cn1)-c1n[nH]c2cc3NC(=O)N(Cc4cccc(c4)C(F)(F)F)Cc3cc12
Show InChI InChI=1S/C22H17F3N6O2/c1-33-20-26-8-14(9-27-20)19-16-6-13-11-31(21(32)28-17(13)7-18(16)29-30-19)10-12-3-2-4-15(5-12)22(23,24)25/h2-9H,10-11H2,1H3,(H,28,32)(H,29,30)
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318169
PNG
(US9624228, Example 125)
Show SMILES COc1ncc(cn1)-c1n[nH]c2cc3NC(=O)N(Cc4cccc(c4)C#N)Cc3cc12
Show InChI InChI=1S/C22H17N7O2/c1-31-21-24-9-16(10-25-21)20-17-6-15-12-29(11-14-4-2-3-13(5-14)8-23)22(30)26-18(15)7-19(17)27-28-20/h2-7,9-10H,11-12H2,1H3,(H,26,30)(H,27,28)
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318183
PNG
(US9624228, Example 139)
Show SMILES Cc1cc(CN2CCC[C@H](C2)N2Cc3cc4c(n[nH]c4cc3NC2=O)-c2ccnc(C)c2)on1
Show InChI InChI=1S/C25H27N7O2/c1-15-8-17(5-6-26-15)24-21-10-18-12-32(25(33)27-22(18)11-23(21)28-29-24)19-4-3-7-31(13-19)14-20-9-16(2)30-34-20/h5-6,8-11,19H,3-4,7,12-14H2,1-2H3,(H,27,33)(H,28,29)/t19-/m1/s1
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318186
PNG
(US9624228, Example 142)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(CC2CC3CCC2C3)C1
Show InChI InChI=1S/C28H34N6O/c1-17-9-20(6-7-29-17)27-24-12-22-15-34(28(35)30-25(22)13-26(24)31-32-27)23-3-2-8-33(16-23)14-21-11-18-4-5-19(21)10-18/h6-7,9,12-13,18-19,21,23H,2-5,8,10-11,14-16H2,1H3,(H,30,35)(H,31,32)/t18?,19?,21?,23-/m1/s1
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318195
PNG
(US9624228, Example 151)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(Cc2ccc(F)cc2)C1
Show InChI InChI=1S/C27H27FN6O/c1-17-11-19(8-9-29-17)26-23-12-20-15-34(27(35)30-24(20)13-25(23)31-32-26)22-3-2-10-33(16-22)14-18-4-6-21(28)7-5-18/h4-9,11-13,22H,2-3,10,14-16H2,1H3,(H,30,35)(H,31,32)/t22-/m1/s1
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318196
PNG
(US9624228, Example 152)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(C1)C(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C27H25ClN6O2/c1-16-10-17(7-8-29-16)25-22-12-19-14-34(27(36)30-23(19)13-24(22)31-32-25)21-6-3-9-33(15-21)26(35)18-4-2-5-20(28)11-18/h2,4-5,7-8,10-13,21H,3,6,9,14-15H2,1H3,(H,30,36)(H,31,32)/t21-/m1/s1
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM318197
PNG
(US9624228, Example 153)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCN(CCc2ccccc2)C1
Show InChI InChI=1S/C27H28N6O/c1-18-13-20(7-10-28-18)26-23-14-21-16-33(27(34)29-24(21)15-25(23)30-31-26)22-9-12-32(17-22)11-8-19-5-3-2-4-6-19/h2-7,10,13-15,22H,8-9,11-12,16-17H2,1H3,(H,29,34)(H,30,31)/t22-/m1/s1
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Kura Oncology, Inc.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US9624228 (2017)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%