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Patent code US9624241

Compile Data Set for Download or QSAR

Found 574 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318453
PNG
(US9624241, Example 1A | US9624241, Example 1B)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(COc1c23)c1ccccc1
Show InChI InChI=1S/C20H17N3O3/c1-11-17(12(2)26-22-11)14-8-9-15-18-19(14)25-10-16(23(18)20(24)21-15)13-6-4-3-5-7-13/h3-9,16H,10H2,1-2H3,(H,21,24)
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US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318453
PNG
(US9624241, Example 1A | US9624241, Example 1B)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(COc1c23)c1ccccc1
Show InChI InChI=1S/C20H17N3O3/c1-11-17(12(2)26-22-11)14-8-9-15-18-19(14)25-10-16(23(18)20(24)21-15)13-6-4-3-5-7-13/h3-9,16H,10H2,1-2H3,(H,21,24)
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US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318458
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-5-methyl-4-phenyl-4,...)
Show SMILES CC1Oc2c(ccc3[nH]c(=O)n(C1c1ccccc1)c23)-c1c(C)noc1C
Show InChI InChI=1S/C21H19N3O3/c1-11-17(12(2)27-23-11)15-9-10-16-19-20(15)26-13(3)18(24(19)21(25)22-16)14-7-5-4-6-8-14/h4-10,13,18H,1-3H3,(H,22,25)
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US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318461
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-4-(3-methoxyphenyl)-...)
Show SMILES COc1cccc(c1)C1COc2c(ccc3[nH]c(=O)n1c23)-c1c(C)noc1C
Show InChI InChI=1S/C21H19N3O4/c1-11-18(12(2)28-23-11)15-7-8-16-19-20(15)27-10-17(24(19)21(25)22-16)13-5-4-6-14(9-13)26-3/h4-9,17H,10H2,1-3H3,(H,22,25)
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US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318475
PNG
(2-{2-[7-(3,5-Dimethylisoxazol-4-yl)-2-oxo-1,2,4,5-...)
Show SMILES CCNC(=O)COc1ccccc1C1COc2c(ccc3[nH]c(=O)n1c23)-c1c(C)noc1C
Show InChI InChI=1S/C24H24N4O5/c1-4-25-20(29)12-31-19-8-6-5-7-15(19)18-11-32-23-16(21-13(2)27-33-14(21)3)9-10-17-22(23)28(18)24(30)26-17/h5-10,18H,4,11-12H2,1-3H3,(H,25,29)(H,26,30)
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US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318475
PNG
(2-{2-[7-(3,5-Dimethylisoxazol-4-yl)-2-oxo-1,2,4,5-...)
Show SMILES CCNC(=O)COc1ccccc1C1COc2c(ccc3[nH]c(=O)n1c23)-c1c(C)noc1C
Show InChI InChI=1S/C24H24N4O5/c1-4-25-20(29)12-31-19-8-6-5-7-15(19)18-11-32-23-16(21-13(2)27-33-14(21)3)9-10-17-22(23)28(18)24(30)26-17/h5-10,18H,4,11-12H2,1-3H3,(H,25,29)(H,26,30)
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US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318484
PNG
(2-{[7-(3,5-Dimethylisoxazol-4-yl)-4-phenyl-4,5-dih...)
Show SMILES CC(CO)Nc1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccc4)n1c23
Show InChI InChI=1S/C23H24N4O3/c1-13(11-28)24-23-25-18-10-9-17(20-14(2)26-30-15(20)3)22-21(18)27(23)19(12-29-22)16-7-5-4-6-8-16/h4-10,13,19,28H,11-12H2,1-3H3,(H,24,25)/t13?,19-/m1/s1
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US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318485
PNG
(2-{[7-(3,5-Dimethylisoxazol-4-yl)-4-phenyl-4,5-dih...)
Show SMILES CC(CO)Nc1nc2ccc(-c3c(C)noc3C)c3OC[C@@H](c4ccccc4)n1c23
Show InChI InChI=1S/C23H24N4O3/c1-13(11-28)24-23-25-18-10-9-17(20-14(2)26-30-15(20)3)22-21(18)27(23)19(12-29-22)16-7-5-4-6-8-16/h4-10,13,19,28H,11-12H2,1-3H3,(H,24,25)/t13?,19-/m0/s1
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US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318497
PNG
(2-{2-[7-(3,5-Dimethylisoxazol- 4-yl)-2-oxo-1,2,4,5...)
Show SMILES CN(C)C(=O)COc1ccccc1C1COc2c(ccc3[nH]c(=O)n1c23)-c1c(C)noc1C
Show InChI InChI=1S/C24H24N4O5/c1-13-21(14(2)33-26-13)16-9-10-17-22-23(16)32-11-18(28(22)24(30)25-17)15-7-5-6-8-19(15)31-12-20(29)27(3)4/h5-10,18H,11-12H2,1-4H3,(H,25,30)
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US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318499
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-4- phenyl-2-pyrrolid...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(N3CCCC3)n3C(COc1c23)c1ccccc1
Show InChI InChI=1S/C24H24N4O2/c1-15-21(16(2)30-26-15)18-10-11-19-22-23(18)29-14-20(17-8-4-3-5-9-17)28(22)24(25-19)27-12-6-7-13-27/h3-5,8-11,20H,6-7,12-14H2,1-2H3
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US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318506
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-4-(1-oxidopyridin-2-...)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(COc1c23)c1cccc[n+]1[O-]
Show InChI InChI=1S/C19H16N4O4/c1-10-16(11(2)27-21-10)12-6-7-13-17-18(12)26-9-15(23(17)19(24)20-13)14-5-3-4-8-22(14)25/h3-8,15H,9H2,1-2H3,(H,20,24)
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US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318507
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-4-(5-fluoropyridin-2...)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(COc1c23)c1ccc(F)cn1
Show InChI InChI=1S/C19H15FN4O3/c1-9-16(10(2)27-23-9)12-4-6-14-17-18(12)26-8-15(24(17)19(25)22-14)13-5-3-11(20)7-21-13/h3-7,15H,8H2,1-2H3,(H,22,25)
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US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318510
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-2-oxo-4-phenyl-1,2,4...)
Show SMILES Cc1noc(C)c1-c1cc(C#N)c2[nH]c(=O)n3C(COc1c23)c1ccccc1
Show InChI InChI=1S/C21H16N4O3/c1-11-17(12(2)28-24-11)15-8-14(9-22)18-19-20(15)27-10-16(25(19)21(26)23-18)13-6-4-3-5-7-13/h3-8,16H,10H2,1-2H3,(H,23,26)
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US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318513
PNG
(9-Bromo-7-(3,5-Dimethylisoxazol-4-yl)-4-phenyl-4,5...)
Show SMILES Cc1noc(C)c1-c1cc(Br)c2[nH]c(=O)n3C(COc1c23)c1ccccc1
Show InChI InChI=1S/C20H16BrN3O3/c1-10-16(11(2)27-23-10)13-8-14(21)17-18-19(13)26-9-15(24(18)20(25)22-17)12-6-4-3-5-7-12/h3-8,15H,9H2,1-2H3,(H,22,25)
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US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318520
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-5,5-dimethyl-4-pyrid...)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(c4ccccn4)C(C)(C)Oc1c23
Show InChI InChI=1S/C21H20N4O3/c1-11-16(12(2)28-24-11)13-8-9-14-17-18(13)27-21(3,4)19(25(17)20(26)23-14)15-7-5-6-10-22-15/h5-10,19H,1-4H3,(H,23,26)
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US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318526
PNG
(N-{[7-(3,5-Dimethylisoxazol-4-yl)-2-oxo-4-pyridin-...)
Show SMILES CC(=O)NCC1(COc2c(ccc3[nH]c(=O)n1c23)-c1c(C)noc1C)c1ccccn1
Show InChI InChI=1S/C22H21N5O4/c1-12-18(13(2)31-26-12)15-7-8-16-19-20(15)30-11-22(10-24-14(3)28,27(19)21(29)25-16)17-6-4-5-9-23-17/h4-9H,10-11H2,1-3H3,(H,24,28)(H,25,29)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318528
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-2-oxo-4-pyridin-2-yl...)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3c2c1OCC3(C(N)=O)c1ccccn1
Show InChI InChI=1S/C20H17N5O4/c1-10-15(11(2)29-24-10)12-6-7-13-16-17(12)28-9-20(18(21)26,25(16)19(27)23-13)14-5-3-4-8-22-14/h3-8H,9H2,1-2H3,(H2,21,26)(H,23,27)
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US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318542
PNG
((4S)-7-(3,5-Dimethylisoxazol-4-yl)-4-pyridin-2-yl-...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(C=C)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C21H18N4O2/c1-4-18-23-16-9-8-14(19-12(2)24-27-13(19)3)21-20(16)25(18)17(11-26-21)15-7-5-6-10-22-15/h4-10,17H,1,11H2,2-3H3/t17-/m1/s1
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318542
PNG
((4S)-7-(3,5-Dimethylisoxazol-4-yl)-4-pyridin-2-yl-...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(C=C)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C21H18N4O2/c1-4-18-23-16-9-8-14(19-12(2)24-27-13(19)3)21-20(16)25(18)17(11-26-21)15-7-5-6-10-22-15/h4-10,17H,1,11H2,2-3H3/t17-/m1/s1
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US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318547
PNG
(US9624241, Example 93 | tert-Butyl (4S)-7-(3,5-dim...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(C(=O)OC(C)(C)C)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C24H24N4O4/c1-13-19(14(2)32-27-13)15-9-10-17-20-21(15)30-12-18(16-8-6-7-11-25-16)28(20)22(26-17)23(29)31-24(3,4)5/h6-11,18H,12H2,1-5H3/t18-/m1/s1
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318547
PNG
(US9624241, Example 93 | tert-Butyl (4S)-7-(3,5-dim...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(C(=O)OC(C)(C)C)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C24H24N4O4/c1-13-19(14(2)32-27-13)15-9-10-17-20-21(15)30-12-18(16-8-6-7-11-25-16)28(20)22(26-17)23(29)31-24(3,4)5/h6-11,18H,12H2,1-5H3/t18-/m1/s1
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US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318552
PNG
(US9624241, Example 98 | tert-Butyl 3-[(4S)-7-(3,5-...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(C3=CCN(C3)C(=O)OC(C)(C)C)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C28H29N5O4/c1-16-23(17(2)37-31-16)19-9-10-21-24-25(19)35-15-22(20-8-6-7-12-29-20)33(24)26(30-21)18-11-13-32(14-18)27(34)36-28(3,4)5/h6-12,22H,13-15H2,1-5H3/t22-/m1/s1
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318557
PNG
((4S)-2-(1-Acetylpiperidin-4-yl)-7-(3,5-dimethyliso...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(C3CCNCC3)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C24H25N5O2/c1-14-21(15(2)31-28-14)17-6-7-19-22-23(17)30-13-20(18-5-3-4-10-26-18)29(22)24(27-19)16-8-11-25-12-9-16/h3-7,10,16,20,25H,8-9,11-13H2,1-2H3/t20-/m1/s1
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318558
PNG
((4S)-7-(3,5-dimethylisoxazol- 4-yl)-4-pyridin-2- y...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(C3=CCNCC3)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C24H23N5O2/c1-14-21(15(2)31-28-14)17-6-7-19-22-23(17)30-13-20(18-5-3-4-10-26-18)29(22)24(27-19)16-8-11-25-12-9-16/h3-8,10,20,25H,9,11-13H2,1-2H3/t20-/m1/s1
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318563
PNG
((4S)-2-(1-Acetylpiperidin-4-yl)-7-(3,5-dimethyliso...)
Show SMILES CC(=O)N1CCC(CC1)c1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccn4)n1c23
Show InChI InChI=1S/C26H27N5O3/c1-15-23(16(2)34-29-15)19-7-8-21-24-25(19)33-14-22(20-6-4-5-11-27-20)31(24)26(28-21)18-9-12-30(13-10-18)17(3)32/h4-8,11,18,22H,9-10,12-14H2,1-3H3/t22-/m1/s1
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318564
PNG
((4S)-2-(1-acetyl-1,2,3,6-tetrahydropyridin- 4-yl)-...)
Show SMILES CC(=O)N1CCC(=CC1)c1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccn4)n1c23
Show InChI InChI=1S/C26H25N5O3/c1-15-23(16(2)34-29-15)19-7-8-21-24-25(19)33-14-22(20-6-4-5-11-27-20)31(24)26(28-21)18-9-12-30(13-10-18)17(3)32/h4-9,11,22H,10,12-14H2,1-3H3/t22-/m1/s1
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318566
PNG
((4S)-7-(3,5-dimethylisoxazol-4-yl)-2-[1- (methylsu...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(C3CCN(CC3)S(C)(=O)=O)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C25H27N5O4S/c1-15-22(16(2)34-28-15)18-7-8-20-23-24(18)33-14-21(19-6-4-5-11-26-19)30(23)25(27-20)17-9-12-29(13-10-17)35(3,31)32/h4-8,11,17,21H,9-10,12-14H2,1-3H3/t21-/m1/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318570
PNG
((4S)-2-[1- (cyclopropylcarbonyl)pyrrolidin-3-yl]-7...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(C3CCN(C3)C(=O)C3CC3)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C27H27N5O3/c1-15-23(16(2)35-30-15)19-8-9-21-24-25(19)34-14-22(20-5-3-4-11-28-20)32(24)26(29-21)18-10-12-31(13-18)27(33)17-6-7-17/h3-5,8-9,11,17-18,22H,6-7,10,12-14H2,1-2H3/t18?,22-/m1/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318572
PNG
((4S)-2-(1-acetyl-1,2,5,6-tetrahydropyridin- 3-yl)-...)
Show SMILES CC(=O)N1CCC=C(C1)c1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccn4)n1c23
Show InChI InChI=1S/C26H25N5O3/c1-15-23(16(2)34-29-15)19-9-10-21-24-25(19)33-14-22(20-8-4-5-11-27-20)31(24)26(28-21)18-7-6-12-30(13-18)17(3)32/h4-5,7-11,22H,6,12-14H2,1-3H3/t22-/m1/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318576
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-4-phenyl-5,6-dihydro...)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(CCc1c23)c1ccccc1
Show InChI InChI=1S/C21H19N3O2/c1-12-19(13(2)26-23-12)15-8-10-17-20-16(15)9-11-18(24(20)21(25)22-17)14-6-4-3-5-7-14/h3-8,10,18H,9,11H2,1-2H3,(H,22,25)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318590
PNG
(N-Cyclopropyl-3-[7- (3,5-dimethylisoxazol- 4-yl)-2...)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(COc1c23)c1cccnc1C(=O)NC1CC1
Show InChI InChI=1S/C23H21N5O4/c1-11-18(12(2)32-27-11)15-7-8-16-20-21(15)31-10-17(28(20)23(30)26-16)14-4-3-9-24-19(14)22(29)25-13-5-6-13/h3-4,7-9,13,17H,5-6,10H2,1-2H3,(H,25,29)(H,26,30)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318593
PNG
((4S)-9-(Aminomethyl)-7-(3,5-dimethylisoxazol-4-yl)...)
Show SMILES Cc1noc(C)c1-c1cc(CN)c2[nH]c(=O)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C20H19N5O3/c1-10-16(11(2)28-24-10)13-7-12(8-21)17-18-19(13)27-9-15(25(18)20(26)23-17)14-5-3-4-6-22-14/h3-7,15H,8-9,21H2,1-2H3,(H,23,26)/t15-/m1/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318603
PNG
(1-[(4S)-7-(3,5-Dimethylisoxazol-4-yl)-4-pyridin-2-...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(N3CCC(C)(O)C3)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C24H25N5O3/c1-14-20(15(2)32-27-14)16-7-8-18-21-22(16)31-12-19(17-6-4-5-10-25-17)29(21)23(26-18)28-11-9-24(3,30)13-28/h4-8,10,19,30H,9,11-13H2,1-3H3/t19-,24?/m1/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318609
PNG
((4S)-7-(3,5-Dimethylisoxazol-4-yl)-2-piperazin-1-y...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(N3CCNCC3)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C23H24N6O2/c1-14-20(15(2)31-27-14)16-6-7-18-21-22(16)30-13-19(17-5-3-4-8-25-17)29(21)23(26-18)28-11-9-24-10-12-28/h3-8,19,24H,9-13H2,1-2H3/t19-/m1/s1
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318612
PNG
(N-{(3R)-1-[(4S)-7-(3,5-Dimethylisoxazol-4-yl)-4-py...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(N3CC[C@H](C3)NC(=O)N3CCOCC3)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C28H31N7O4/c1-17-24(18(2)39-32-17)20-6-7-22-25-26(20)38-16-23(21-5-3-4-9-29-21)35(25)27(31-22)34-10-8-19(15-34)30-28(36)33-11-13-37-14-12-33/h3-7,9,19,23H,8,10-16H2,1-2H3,(H,30,36)/t19-,23-/m1/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318614
PNG
(Methyl {(3R)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)...)
Show SMILES COC(=O)N[C@@H]1CCN(C1)c1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccn4)n1c23
Show InChI InChI=1S/C25H26N6O4/c1-14-21(15(2)35-29-14)17-7-8-19-22-23(17)34-13-20(18-6-4-5-10-26-18)31(22)24(28-19)30-11-9-16(12-30)27-25(32)33-3/h4-8,10,16,20H,9,11-13H2,1-3H3,(H,27,32)/t16-,20-/m1/s1
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318617
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-N-ethyl-9-fluoro-4-p...)
Show SMILES CCNc1nc2c(F)cc(-c3c(C)noc3C)c3OCC(c4cccnc4)n1c23
Show InChI InChI=1S/C21H20FN5O2/c1-4-24-21-25-18-15(22)8-14(17-11(2)26-29-12(17)3)20-19(18)27(21)16(10-28-20)13-6-5-7-23-9-13/h5-9,16H,4,10H2,1-3H3,(H,24,25)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318619
PNG
(US9624241, Example 159B)
Show SMILES Cc1noc(C)c1-c1ccc2nc(N3CC[C@H](O)C3)n3C(COc1c23)c1cccnc1
Show InChI InChI=1S/C23H23N5O3/c1-13-20(14(2)31-26-13)17-5-6-18-21-22(17)30-12-19(15-4-3-8-24-10-15)28(21)23(25-18)27-9-7-16(29)11-27/h3-6,8,10,16,19,29H,7,9,11-12H2,1-2H3/t16-,19?/m0/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318628
PNG
((4S)-7-(3,5-dimethylisoxazol-4-yl)-4- pyridin-2-yl...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(N3CCCC3)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C23H23N5O2/c1-14-20(15(2)30-26-14)16-8-9-18-21-22(16)29-13-19(17-7-3-4-10-24-17)28(21)23(25-18)27-11-5-6-12-27/h3-4,7-10,19H,5-6,11-13H2,1-2H3/t19-/m1/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318658
PNG
(7-(3,5-dimethylisoxazol-4-yl)-N,N- dimethyl-4-pyri...)
Show SMILES CN(C)c1nc2ccc(-c3c(C)noc3C)c3OCC(c4ccccn4)n1c23
Show InChI InChI=1S/C21H21N5O2/c1-12-18(13(2)28-24-12)14-8-9-16-19-20(14)27-11-17(15-7-5-6-10-22-15)26(19)21(23-16)25(3)4/h5-10,17H,11H2,1-4H3
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318659
PNG
(1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4- pyridin-2...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(N3CCC(CC3)C(N)=O)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C25H26N6O3/c1-14-21(15(2)34-29-14)17-6-7-19-22-23(17)33-13-20(18-5-3-4-10-27-18)31(22)25(28-19)30-11-8-16(9-12-30)24(26)32/h3-7,10,16,20H,8-9,11-13H2,1-2H3,(H2,26,32)/t20-/m1/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318664
PNG
((4S)-7-(3,5-dimethylisoxazol-4-yl)-2- [(8aS)-hexah...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(N3CCN4CCC[C@H]4C3)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C26H28N6O2/c1-16-23(17(2)34-29-16)19-8-9-21-24-25(19)33-15-22(20-7-3-4-10-27-20)32(24)26(28-21)31-13-12-30-11-5-6-18(30)14-31/h3-4,7-10,18,22H,5-6,11-15H2,1-2H3/t18-,22+/m0/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318674
PNG
(N-{(3S)-1-[(4S)-7-(3,5- dimethylisoxazol-4-yl)-4-p...)
Show SMILES CC(=O)N[C@H]1CCN(C1)c1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccn4)n1c23
Show InChI InChI=1S/C25H26N6O3/c1-14-22(15(2)34-29-14)18-7-8-20-23-24(18)33-13-21(19-6-4-5-10-26-19)31(23)25(28-20)30-11-9-17(12-30)27-16(3)32/h4-8,10,17,21H,9,11-13H2,1-3H3,(H,27,32)/t17-,21+/m0/s1
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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318680
PNG
(N-{(3R)-1-[(4S)-7-(3,5- dimethylisoxazol-4-yl)-4-p...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(N3CC[C@H](C3)NS(C)(=O)=O)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C24H26N6O4S/c1-14-21(15(2)34-27-14)17-7-8-19-22-23(17)33-13-20(18-6-4-5-10-25-18)30(22)24(26-19)29-11-9-16(12-29)28-35(3,31)32/h4-8,10,16,20,28H,9,11-13H2,1-3H3/t16-,20-/m1/s1
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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318681
PNG
(N-{(3R)-1-[(4S)-7-(3,5- dimethylisoxazol-4-yl)-4-p...)
Show SMILES CCC(=O)N[C@@H]1CCN(C1)c1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccn4)n1c23
Show InChI InChI=1S/C26H28N6O3/c1-4-22(33)28-17-10-12-31(13-17)26-29-20-9-8-18(23-15(2)30-35-16(23)3)25-24(20)32(26)21(14-34-25)19-7-5-6-11-27-19/h5-9,11,17,21H,4,10,12-14H2,1-3H3,(H,28,33)/t17-,21-/m1/s1
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US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318684
PNG
(2-cyano-N-{(3R)-1-[(4S)-7-(3,5- dimethylisoxazol-4...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(N3CC[C@H](C3)NC(=O)CC#N)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C26H25N7O3/c1-15-23(16(2)36-31-15)18-6-7-20-24-25(18)35-14-21(19-5-3-4-11-28-19)33(24)26(30-20)32-12-9-17(13-32)29-22(34)8-10-27/h3-7,11,17,21H,8-9,12-14H2,1-2H3,(H,29,34)/t17-,21-/m1/s1
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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318688
PNG
(N'-{(3R)-1-[(4S)-7-(3,5- dimethylisoxazol-4-yl)-4-...)
Show SMILES CN(C)C(=O)N[C@@H]1CCN(C1)c1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccn4)n1c23
Show InChI InChI=1S/C26H29N7O3/c1-15-22(16(2)36-30-15)18-8-9-20-23-24(18)35-14-21(19-7-5-6-11-27-19)33(23)25(29-20)32-12-10-17(13-32)28-26(34)31(3)4/h5-9,11,17,21H,10,12-14H2,1-4H3,(H,28,34)/t17-,21-/m1/s1
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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318690
PNG
(N-{(3R)-1-[(4S)-7-(3,5- dimethylisoxazol-4-yl)-4-p...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(N3CC[C@H](C3)NS(=O)(=O)C3CC3)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C26H28N6O4S/c1-15-23(16(2)36-29-15)19-8-9-21-24-25(19)35-14-22(20-5-3-4-11-27-20)32(24)26(28-21)31-12-10-17(13-31)30-37(33,34)18-6-7-18/h3-5,8-9,11,17-18,22,30H,6-7,10,12-14H2,1-2H3/t17-,22-/m1/s1
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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318700
PNG
(1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4- pyridin-2...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(N3CC(N)C3)n3[C@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C22H22N6O2/c1-12-19(13(2)30-26-12)15-6-7-17-20-21(15)29-11-18(16-5-3-4-8-24-16)28(20)22(25-17)27-9-14(23)10-27/h3-8,14,18H,9-11,23H2,1-2H3/t18-/m1/s1
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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318702
PNG
(N-{1-[(4S)-7-(3,5-dimethylisoxazol-4- yl)-4-pyridi...)
Show SMILES CCC(=O)NC1CN(C1)c1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccn4)n1c23
Show InChI InChI=1S/C25H26N6O3/c1-4-21(32)27-16-11-30(12-16)25-28-19-9-8-17(22-14(2)29-34-15(22)3)24-23(19)31(25)20(13-33-24)18-7-5-6-10-26-18/h5-10,16,20H,4,11-13H2,1-3H3,(H,27,32)/t20-/m1/s1
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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%