BindingDB logo
myBDB logout

Patent code US9630929

Compile Data Set for Download or QSAR
Found 138 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323113
PNG
(Synthesis of 4-((trans-4-(3,4-dichlorophenyl)piper...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(Cl)c(Cl)c1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H18Cl2F2N4O3S2/c21-14-2-1-11(5-15(14)22)13-3-4-25-8-12(13)9-31-18-6-17(24)19(7-16(18)23)33(29,30)28-20-26-10-27-32-20/h1-2,5-7,10,12-13,25H,3-4,8-9H2,(H,26,27,28)/t12-,13?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.800n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323121
PNG
(Synthesis of 4-((trans-4-(4-chloro-3-fluorophenyl(...)
Show SMILES Fc1cc(ccc1Cl)C1CCNC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H18ClF3N4O3S2/c21-14-2-1-11(5-15(14)22)13-3-4-25-8-12(13)9-31-18-6-17(24)19(7-16(18)23)33(29,30)28-20-26-10-27-32-20/h1-2,5-7,10,12-13,25H,3-4,8-9H2,(H,26,27,28)/t12-,13?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.900n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50024246
PNG
(CHEMBL3325526 | US9630929, Example 77)
Show SMILES Fc1cc(c(F)cc1OC[C@H]1CNCC[C@@H]1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H19ClF2N4O3S2/c21-14-3-1-12(2-4-14)15-5-6-24-9-13(15)10-30-18-7-17(23)19(8-16(18)22)32(28,29)27-20-25-11-26-31-20/h1-4,7-8,11,13,15,24H,5-6,9-10H2,(H,25,26,27)/t13-,15-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.10n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM316501
PNG
(Synthesis of 4-((trans-4-(3,4-difluorophenyl)piper...)
Show SMILES Fc1ccc(cc1F)C1CCNC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H18F4N4O3S2/c21-14-2-1-11(5-15(14)22)13-3-4-25-8-12(13)9-31-18-6-17(24)19(7-16(18)23)33(29,30)28-20-26-10-27-32-20/h1-2,5-7,10,12-13,25H,3-4,8-9H2,(H,26,27,28)/t12-,13?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.60n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM316478
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H19ClF2N4O3S2/c21-14-3-1-12(2-4-14)15-5-6-24-9-13(15)10-30-18-7-17(23)19(8-16(18)22)32(28,29)27-20-25-11-26-31-20/h1-4,7-8,11,13,15,24H,5-6,9-10H2,(H,25,26,27)/t13-,15?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.30n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323086
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Clc1ccc(cc1)C1CCNC[C@H]1COc1ccc(cc1C#N)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H20ClN5O3S2/c22-17-3-1-14(2-4-17)19-7-8-24-11-16(19)12-30-20-6-5-18(9-15(20)10-23)32(28,29)27-21-25-13-26-31-21/h1-6,9,13,16,19,24H,7-8,11-12H2,(H,25,26,27)/t16-,19?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.30n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50024217
PNG
(CHEMBL3325537 | US9630929, Example 85)
Show SMILES CN1CC[C@@H]([C@@H](COc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClF2N4O3S2/c1-28-7-6-16(13-2-4-15(22)5-3-13)14(10-28)11-31-19-8-18(24)20(9-17(19)23)33(29,30)27-21-25-12-26-32-21/h2-5,8-9,12,14,16H,6-7,10-11H2,1H3,(H,25,26,27)/t14-,16-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.80n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM316481
PNG
(Synthesis of 2,5-difluoro-4-((trans-4-(4-fluorophe...)
Show SMILES Fc1ccc(cc1)C1CCNC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H19F3N4O3S2/c21-14-3-1-12(2-4-14)15-5-6-24-9-13(15)10-30-18-7-17(23)19(8-16(18)22)32(28,29)27-20-25-11-26-31-20/h1-4,7-8,11,13,15,24H,5-6,9-10H2,(H,25,26,27)/t13-,15?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.80n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323087
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Fc1cc(ccc1OC[C@@H]1CNCCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H20ClFN4O3S2/c21-15-3-1-13(2-4-15)17-7-8-23-10-14(17)11-29-19-6-5-16(9-18(19)22)31(27,28)26-20-24-12-25-30-20/h1-6,9,12,14,17,23H,7-8,10-11H2,(H,24,25,26)/t14-,17?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 8.60n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323097
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)-1-methyl...)
Show SMILES CN1CCC([C@H](COc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClF2N4O3S2/c1-28-7-6-16(13-2-4-15(22)5-3-13)14(10-28)11-31-19-8-18(24)20(9-17(19)23)33(29,30)27-21-25-12-26-32-21/h2-5,8-9,12,14,16H,6-7,10-11H2,1H3,(H,25,26,27)/t14-,16?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 12n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323089
PNG
(Synthesis of N-(5-chlorothiazol-2-yl)-4-(trans-4-(...)
Show SMILES Fc1ccc(cc1F)C1CCNC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncc(Cl)s1
Show InChI InChI=1S/C21H18ClF4N3O3S2/c22-20-9-28-21(33-20)29-34(30,31)19-7-16(25)18(6-17(19)26)32-10-12-8-27-4-3-13(12)11-1-2-14(23)15(24)5-11/h1-2,5-7,9,12-13,27H,3-4,8,10H2,(H,28,29)/t12-,13?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 21.6n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323090
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncc(Cl)s1
Show InChI InChI=1S/C21H19Cl2F2N3O3S2/c22-14-3-1-12(2-4-14)15-5-6-26-9-13(15)11-31-18-7-17(25)19(8-16(18)24)33(29,30)28-21-27-10-20(23)32-21/h1-4,7-8,10,13,15,26H,5-6,9,11H2,(H,27,28)/t13-,15?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 23n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323103
PNG
(Synthesis of 2,5-difluoro-4-((trans-3-(4-fluorophe...)
Show SMILES Fc1ccc(cc1)C1CNCC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H19F3N4O3S2/c21-14-3-1-12(2-4-14)15-9-24-6-5-13(15)10-30-18-7-17(23)19(8-16(18)22)32(28,29)27-20-25-11-26-31-20/h1-4,7-8,11,13,15,24H,5-6,9-10H2,(H,25,26,27)/t13-,15?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 31.7n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323088
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C22H21ClF2N4O3S/c23-16-3-1-14(2-4-16)17-5-7-26-11-15(17)12-32-20-9-19(25)21(10-18(20)24)33(30,31)29-22-6-8-27-13-28-22/h1-4,6,8-10,13,15,17,26H,5,7,11-12H2,(H,27,28,29)/t15-,17?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 33n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323135
PNG
(Synthesis of 2,5-difluoro-4-((trans-4-(4-fluoro-3-...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(F)c(c1)C(F)(F)F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H18F6N4O3S2/c22-15-2-1-11(5-14(15)21(25,26)27)13-3-4-28-8-12(13)9-34-18-6-17(24)19(7-16(18)23)36(32,33)31-20-29-10-30-35-20/h1-2,5-7,10,12-13,28H,3-4,8-9H2,(H,29,30,31)/t12-,13?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 38n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323104
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)-1-(2,2-d...)
Show SMILES FC(F)CN1CCC([C@H](COc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H21ClF4N4O3S2/c23-15-3-1-13(2-4-15)16-5-6-31(10-21(26)27)9-14(16)11-34-19-7-18(25)20(8-17(19)24)36(32,33)30-22-28-12-29-35-22/h1-4,7-8,12,14,16,21H,5-6,9-11H2,(H,28,29,30)/t14-,16?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 38.1n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323083
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)pyrrolidi...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C19H17ClF2N4O3S2/c20-13-3-1-11(2-4-13)14-8-23-7-12(14)9-29-17-5-16(22)18(6-15(17)21)31(27,28)26-19-24-10-25-30-19/h1-6,10,12,14,23H,7-9H2,(H,24,25,26)/t12-,14?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 49.9n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50024132
PNG
(CHEMBL3325530 | US9630929, Example 47)
Show SMILES Fc1ccc(cc1)C1CCNCC1(F)COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H18F4N4O3S2/c21-13-3-1-12(2-4-13)14-5-6-25-9-20(14,24)10-31-17-7-16(23)18(8-15(17)22)33(29,30)28-19-26-11-27-32-19/h1-4,7-8,11,14,25H,5-6,9-10H2,(H,26,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 50.7n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM316502
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncccn1
Show InChI InChI=1S/C22H21ClF2N4O3S/c23-16-4-2-14(3-5-16)17-6-9-26-12-15(17)13-32-20-10-19(25)21(11-18(20)24)33(30,31)29-22-27-7-1-8-28-22/h1-5,7-8,10-11,15,17,26H,6,9,12-13H2,(H,27,28,29)/t15-,17?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 53.2n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM316478
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H19ClF2N4O3S2/c21-14-3-1-12(2-4-14)15-5-6-24-9-13(15)10-30-18-7-17(23)19(8-16(18)22)32(28,29)27-20-25-11-26-31-20/h1-4,7-8,11,13,15,24H,5-6,9-10H2,(H,25,26,27)/t13-,15?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 58.8n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323091
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Fc1ccc(NS(=O)(=O)c2cc(F)c(OC[C@@H]3CNCCC3c3ccc(Cl)cc3)cc2F)nc1
Show InChI InChI=1S/C23H21ClF3N3O3S/c24-16-3-1-14(2-4-16)18-7-8-28-11-15(18)13-33-21-9-20(27)22(10-19(21)26)34(31,32)30-23-6-5-17(25)12-29-23/h1-6,9-10,12,15,18,28H,7-8,11,13H2,(H,29,30)/t15-,18?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 70.5n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323135
PNG
(Synthesis of 2,5-difluoro-4-((trans-4-(4-fluoro-3-...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(F)c(c1)C(F)(F)F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H18F6N4O3S2/c22-15-2-1-11(5-14(15)21(25,26)27)13-3-4-28-8-12(13)9-34-18-6-17(24)19(7-16(18)23)36(32,33)31-20-29-10-30-35-20/h1-2,5-7,10,12-13,28H,3-4,8-9H2,(H,29,30,31)/t12-,13?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 71n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323092
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Fc1cnc(NS(=O)(=O)c2cc(F)c(OC[C@@H]3CNCCC3c3ccc(Cl)cc3)cc2F)nc1
Show InChI InChI=1S/C22H20ClF3N4O3S/c23-15-3-1-13(2-4-15)17-5-6-27-9-14(17)12-33-20-7-19(26)21(8-18(20)25)34(31,32)30-22-28-10-16(24)11-29-22/h1-4,7-8,10-11,14,17,27H,5-6,9,12H2,(H,28,29,30)/t14-,17?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 76.4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323108
PNG
(Synthesis of 2,5-difluoro-4-((trans-4-(4-fluorophe...)
Show SMILES Fc1ccc(cc1)C1CC(=O)NC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H17F3N4O4S2/c21-13-3-1-11(2-4-13)14-5-19(28)24-8-12(14)9-31-17-6-16(23)18(7-15(17)22)33(29,30)27-20-25-10-26-32-20/h1-4,6-7,10,12,14H,5,8-9H2,(H,24,28)(H,25,26,27)/t12-,14?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 82n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323081
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1nncs1
Show InChI InChI=1S/C20H19ClF2N4O3S2/c21-14-3-1-12(2-4-14)15-5-6-24-9-13(15)10-30-18-7-17(23)19(8-16(18)22)32(28,29)27-20-26-25-11-31-20/h1-4,7-8,11,13,15,24H,5-6,9-10H2,(H,26,27)/t13-,15?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 84.4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323101
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)-1-(2-flu...)
Show SMILES FCCN1CCC([C@H](COc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H22ClF3N4O3S2/c23-16-3-1-14(2-4-16)17-5-7-30(8-6-24)11-15(17)12-33-20-9-19(26)21(10-18(20)25)35(31,32)29-22-27-13-28-34-22/h1-4,9-10,13,15,17H,5-8,11-12H2,(H,27,28,29)/t15-,17?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 93.7n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323081
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1nncs1
Show InChI InChI=1S/C20H19ClF2N4O3S2/c21-14-3-1-12(2-4-14)15-5-6-24-9-13(15)10-30-18-7-17(23)19(8-16(18)22)32(28,29)27-20-26-25-11-31-20/h1-4,7-8,11,13,15,24H,5-6,9-10H2,(H,26,27)/t13-,15?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323083
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)pyrrolidi...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C19H17ClF2N4O3S2/c20-13-3-1-11(2-4-13)14-8-23-7-12(14)9-29-17-5-16(22)18(6-15(17)21)31(27,28)26-19-24-10-25-30-19/h1-6,10,12,14,23H,7-9H2,(H,24,25,26)/t12-,14?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323121
PNG
(Synthesis of 4-((trans-4-(4-chloro-3-fluorophenyl(...)
Show SMILES Fc1cc(ccc1Cl)C1CCNC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H18ClF3N4O3S2/c21-14-2-1-11(5-15(14)22)13-3-4-25-8-12(13)9-31-18-6-17(24)19(7-16(18)23)33(29,30)28-20-26-10-27-32-20/h1-2,5-7,10,12-13,25H,3-4,8-9H2,(H,26,27,28)/t12-,13?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM316501
PNG
(Synthesis of 4-((trans-4-(3,4-difluorophenyl)piper...)
Show SMILES Fc1ccc(cc1F)C1CCNC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H18F4N4O3S2/c21-14-2-1-11(5-15(14)22)13-3-4-25-8-12(13)9-31-18-6-17(24)19(7-16(18)23)33(29,30)28-20-26-10-27-32-20/h1-2,5-7,10,12-13,25H,3-4,8-9H2,(H,26,27,28)/t12-,13?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323091
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Fc1ccc(NS(=O)(=O)c2cc(F)c(OC[C@@H]3CNCCC3c3ccc(Cl)cc3)cc2F)nc1
Show InChI InChI=1S/C23H21ClF3N3O3S/c24-16-3-1-14(2-4-16)18-7-8-28-11-15(18)13-33-21-9-20(27)22(10-19(21)26)34(31,32)30-23-6-5-17(25)12-29-23/h1-6,9-10,12,15,18,28H,7-8,11,13H2,(H,29,30)/t15-,18?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM316478
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H19ClF2N4O3S2/c21-14-3-1-12(2-4-14)15-5-6-24-9-13(15)10-30-18-7-17(23)19(8-16(18)22)32(28,29)27-20-25-11-26-31-20/h1-4,7-8,11,13,15,24H,5-6,9-10H2,(H,25,26,27)/t13-,15?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50024217
PNG
(CHEMBL3325537 | US9630929, Example 85)
Show SMILES CN1CC[C@@H]([C@@H](COc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClF2N4O3S2/c1-28-7-6-16(13-2-4-15(22)5-3-13)14(10-28)11-31-19-8-18(24)20(9-17(19)23)33(29,30)27-21-25-12-26-32-21/h2-5,8-9,12,14,16H,6-7,10-11H2,1H3,(H,25,26,27)/t14-,16-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM316502
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncccn1
Show InChI InChI=1S/C22H21ClF2N4O3S/c23-16-4-2-14(3-5-16)17-6-9-26-12-15(17)13-32-20-10-19(25)21(11-18(20)24)33(30,31)29-22-27-7-1-8-28-22/h1-5,7-8,10-11,15,17,26H,6,9,12-13H2,(H,27,28,29)/t15-,17?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323086
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Clc1ccc(cc1)C1CCNC[C@H]1COc1ccc(cc1C#N)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H20ClN5O3S2/c22-17-3-1-14(2-4-17)19-7-8-24-11-16(19)12-30-20-6-5-18(9-15(20)10-23)32(28,29)27-21-25-13-26-31-21/h1-6,9,13,16,19,24H,7-8,11-12H2,(H,25,26,27)/t16-,19?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323097
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)-1-methyl...)
Show SMILES CN1CCC([C@H](COc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClF2N4O3S2/c1-28-7-6-16(13-2-4-15(22)5-3-13)14(10-28)11-31-19-8-18(24)20(9-17(19)23)33(29,30)27-21-25-12-26-32-21/h2-5,8-9,12,14,16H,6-7,10-11H2,1H3,(H,25,26,27)/t14-,16?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323104
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)-1-(2,2-d...)
Show SMILES FC(F)CN1CCC([C@H](COc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H21ClF4N4O3S2/c23-15-3-1-13(2-4-15)16-5-6-31(10-21(26)27)9-14(16)11-34-19-7-18(25)20(8-17(19)24)36(32,33)30-22-28-12-29-35-22/h1-4,7-8,12,14,16,21H,5-6,9-11H2,(H,28,29,30)/t14-,16?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM316478
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H19ClF2N4O3S2/c21-14-3-1-12(2-4-14)15-5-6-24-9-13(15)10-30-18-7-17(23)19(8-16(18)22)32(28,29)27-20-25-11-26-31-20/h1-4,7-8,11,13,15,24H,5-6,9-10H2,(H,25,26,27)/t13-,15?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM316481
PNG
(Synthesis of 2,5-difluoro-4-((trans-4-(4-fluorophe...)
Show SMILES Fc1ccc(cc1)C1CCNC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H19F3N4O3S2/c21-14-3-1-12(2-4-14)15-5-6-24-9-13(15)10-30-18-7-17(23)19(8-16(18)22)32(28,29)27-20-25-11-26-31-20/h1-4,7-8,11,13,15,24H,5-6,9-10H2,(H,25,26,27)/t13-,15?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323087
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Fc1cc(ccc1OC[C@@H]1CNCCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H20ClFN4O3S2/c21-15-3-1-13(2-4-15)17-7-8-23-10-14(17)11-29-19-6-5-16(9-18(19)22)31(27,28)26-20-24-12-25-30-20/h1-6,9,12,14,17,23H,7-8,10-11H2,(H,24,25,26)/t14-,17?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323092
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Fc1cnc(NS(=O)(=O)c2cc(F)c(OC[C@@H]3CNCCC3c3ccc(Cl)cc3)cc2F)nc1
Show InChI InChI=1S/C22H20ClF3N4O3S/c23-15-3-1-13(2-4-15)17-5-6-27-9-14(17)12-33-20-7-19(26)21(8-18(20)25)34(31,32)30-22-28-10-16(24)11-29-22/h1-4,7-8,10-11,14,17,27H,5-6,9,12H2,(H,28,29,30)/t14-,17?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323103
PNG
(Synthesis of 2,5-difluoro-4-((trans-3-(4-fluorophe...)
Show SMILES Fc1ccc(cc1)C1CNCC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H19F3N4O3S2/c21-14-3-1-12(2-4-14)15-9-24-6-5-13(15)10-30-18-7-17(23)19(8-16(18)22)32(28,29)27-20-25-11-26-31-20/h1-4,7-8,11,13,15,24H,5-6,9-10H2,(H,25,26,27)/t13-,15?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323108
PNG
(Synthesis of 2,5-difluoro-4-((trans-4-(4-fluorophe...)
Show SMILES Fc1ccc(cc1)C1CC(=O)NC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H17F3N4O4S2/c21-13-3-1-11(2-4-13)14-5-19(28)24-8-12(14)9-31-17-6-16(23)18(7-15(17)22)33(29,30)27-20-25-10-26-32-20/h1-4,6-7,10,12,14H,5,8-9H2,(H,24,28)(H,25,26,27)/t12-,14?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323089
PNG
(Synthesis of N-(5-chlorothiazol-2-yl)-4-(trans-4-(...)
Show SMILES Fc1ccc(cc1F)C1CCNC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncc(Cl)s1
Show InChI InChI=1S/C21H18ClF4N3O3S2/c22-20-9-28-21(33-20)29-34(30,31)19-7-16(25)18(6-17(19)26)32-10-12-8-27-4-3-13(12)11-1-2-14(23)15(24)5-11/h1-2,5-7,9,12-13,27H,3-4,8,10H2,(H,28,29)/t12-,13?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323101
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)-1-(2-flu...)
Show SMILES FCCN1CCC([C@H](COc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H22ClF3N4O3S2/c23-16-3-1-14(2-4-16)17-5-7-30(8-6-24)11-15(17)12-33-20-9-19(26)21(10-18(20)25)35(31,32)29-22-27-13-28-34-22/h1-4,9-10,13,15,17H,5-8,11-12H2,(H,27,28,29)/t15-,17?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50024132
PNG
(CHEMBL3325530 | US9630929, Example 47)
Show SMILES Fc1ccc(cc1)C1CCNCC1(F)COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H18F4N4O3S2/c21-13-3-1-12(2-4-13)14-5-6-25-9-20(14,24)10-31-17-7-16(23)18(8-15(17)22)33(29,30)28-19-26-11-27-32-19/h1-4,7-8,11,14,25H,5-6,9-10H2,(H,26,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323088
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C22H21ClF2N4O3S/c23-16-3-1-14(2-4-16)17-5-7-26-11-15(17)12-32-20-9-19(25)21(10-18(20)24)33(30,31)29-22-6-8-27-13-28-22/h1-4,6,8-10,13,15,17,26H,5,7,11-12H2,(H,27,28,29)/t15-,17?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323090
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncc(Cl)s1
Show InChI InChI=1S/C21H19Cl2F2N3O3S2/c22-14-3-1-12(2-4-14)15-5-6-26-9-13(15)11-31-18-7-17(25)19(8-16(18)24)33(29,30)28-21-27-10-20(23)32-21/h1-4,7-8,10,13,15,26H,5-6,9,11H2,(H,27,28)/t13-,15?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323113
PNG
(Synthesis of 4-((trans-4-(3,4-dichlorophenyl)piper...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(Cl)c(Cl)c1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H18Cl2F2N4O3S2/c21-14-2-1-11(5-15(14)22)13-3-4-25-8-12(13)9-31-18-6-17(24)19(7-16(18)23)33(29,30)28-20-26-10-27-32-20/h1-2,5-7,10,12-13,25H,3-4,8-9H2,(H,26,27,28)/t12-,13?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50024246
PNG
(CHEMBL3325526 | US9630929, Example 77)
Show SMILES Fc1cc(c(F)cc1OC[C@H]1CNCC[C@@H]1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H19ClF2N4O3S2/c21-14-3-1-12(2-4-14)15-5-6-24-9-13(15)10-30-18-7-17(23)19(8-16(18)22)32(28,29)27-20-25-11-26-31-20/h1-4,7-8,11,13,15,24H,5-6,9-10H2,(H,25,26,27)/t13-,15-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323085
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Cc1cnc(NS(=O)(=O)c2cc(F)c(OC[C@@H]3CNCCC3c3ccc(Cl)cc3)cc2F)o1
Show InChI InChI=1S/C22H22ClF2N3O4S/c1-13-10-27-22(32-13)28-33(29,30)21-9-18(24)20(8-19(21)25)31-12-15-11-26-7-6-17(15)14-2-4-16(23)5-3-14/h2-5,8-10,15,17,26H,6-7,11-12H2,1H3,(H,27,28)/t15-,17?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 116n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323109
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)-1-(2,2,2...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CN(CC(F)(F)F)CCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C22H20ClF5N4O3S2/c23-15-3-1-13(2-4-15)16-5-6-32(11-22(26,27)28)9-14(16)10-35-19-7-18(25)20(8-17(19)24)37(33,34)31-21-29-12-30-36-21/h1-4,7-8,12,14,16H,5-6,9-11H2,(H,29,30,31)/t14-,16?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 130n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323116
PNG
(Synthesis of 2,5-difluoro-4-((trans-4-(4-methoxyph...)
Show SMILES COc1ccc(cc1)C1CCNC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H22F2N4O4S2/c1-30-15-4-2-13(3-5-15)16-6-7-24-10-14(16)11-31-19-8-18(23)20(9-17(19)22)33(28,29)27-21-25-12-26-32-21/h2-5,8-9,12,14,16,24H,6-7,10-11H2,1H3,(H,25,26,27)/t14-,16?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 132n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323096
PNG
(Synthesis of trans-tert-butyl 3-((4-(N-(1,2,4-thia...)
Show SMILES CC(C)(C)OC(=O)N1CCC([C@H](COc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H27ClF2N4O5S2/c1-25(2,3)37-24(33)32-9-8-18(15-4-6-17(26)7-5-15)16(12-32)13-36-21-10-20(28)22(11-19(21)27)39(34,35)31-23-29-14-30-38-23/h4-7,10-11,14,16,18H,8-9,12-13H2,1-3H3,(H,29,30,31)/t16-,18?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 164n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323093
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1cccnn1
Show InChI InChI=1S/C22H21ClF2N4O3S/c23-16-5-3-14(4-6-16)17-7-9-26-12-15(17)13-32-20-10-19(25)21(11-18(20)24)33(30,31)29-22-2-1-8-27-28-22/h1-6,8,10-11,15,17,26H,7,9,12-13H2,(H,28,29)/t15-,17?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 171n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323132
PNG
(Synthesis of 2,5-difluoro-N-(1,2,4-thiadiazol-5-yl...)
Show SMILES Fc1cc(F)c(cc1F)C1CCNC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H17F5N4O3S2/c21-13-4-15(23)14(22)3-12(13)11-1-2-26-7-10(11)8-32-18-5-17(25)19(6-16(18)24)34(30,31)29-20-27-9-28-33-20/h3-6,9-11,26H,1-2,7-8H2,(H,27,28,29)/t10-,11?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 181n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323082
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Cc1nsc(NS(=O)(=O)c2cc(F)c(OC[C@@H]3CNCCC3c3ccc(Cl)cc3)cc2F)n1
Show InChI InChI=1S/C21H21ClF2N4O3S2/c1-12-26-21(32-27-12)28-33(29,30)20-9-17(23)19(8-18(20)24)31-11-14-10-25-7-6-16(14)13-2-4-15(22)5-3-13/h2-5,8-9,14,16,25H,6-7,10-11H2,1H3,(H,26,27,28)/t14-,16?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 194n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323094
PNG
(Synthesis of 4-((cis-4-(4-chlorophenyl)piperidin-3...)
Show SMILES Fc1cc(c(F)cc1OC[C@H]1CNCCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H19ClF2N4O3S2/c21-14-3-1-12(2-4-14)15-5-6-24-9-13(15)10-30-18-7-17(23)19(8-16(18)22)32(28,29)27-20-25-11-26-31-20/h1-4,7-8,11,13,15,24H,5-6,9-10H2,(H,25,26,27)/t13-,15?/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 237n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323139
PNG
(Synthesis of 4-((trans-2-(4-chlorophenyl)-5-oxocyc...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CC(=O)CC[C@H]1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H18ClF2N3O4S2/c22-14-3-1-12(2-4-14)16-6-5-15(28)7-13(16)10-31-19-8-18(24)20(9-17(19)23)33(29,30)27-21-25-11-26-32-21/h1-4,8-9,11,13,16H,5-7,10H2,(H,25,26,27)/t13-,16-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 244n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323095
PNG
(Synthesis of 2,5-difluoro-4-((trans-2-(4-fluorophe...)
Show SMILES Fc1ccc(cc1)C1CCCC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H20F3N3O3S2/c22-15-7-5-13(6-8-15)16-4-2-1-3-14(16)11-30-19-9-18(24)20(10-17(19)23)32(28,29)27-21-25-12-26-31-21/h5-10,12,14,16H,1-4,11H2,(H,25,26,27)/t14-,16?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 280n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM316503
PNG
(Synthesis of 2,5-difluoro-4-((trans-4-(4-fluorophe...)
Show SMILES Fc1ccc(cc1)C1CCNC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncccn1
Show InChI InChI=1S/C22H21F3N4O3S/c23-16-4-2-14(3-5-16)17-6-9-26-12-15(17)13-32-20-10-19(25)21(11-18(20)24)33(30,31)29-22-27-7-1-8-28-22/h1-5,7-8,10-11,15,17,26H,6,9,12-13H2,(H,27,28,29)/t15-,17?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 323n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323142
PNG
(Synthesis of 44(1-(4-chlorophenyl)piperazin-2-yl)m...)
Show SMILES Fc1cc(c(F)cc1OCC1CNCCN1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C19H18ClF2N5O3S2/c20-12-1-3-13(4-2-12)27-6-5-23-9-14(27)10-30-17-7-16(22)18(8-15(17)21)32(28,29)26-19-24-11-25-31-19/h1-4,7-8,11,14,23H,5-6,9-10H2,(H,24,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 326n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50024216
PNG
(CHEMBL3325536 | US9630929, Example 86)
Show SMILES CN1CC[C@H]([C@H](COc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClF2N4O3S2/c1-28-7-6-16(13-2-4-15(22)5-3-13)14(10-28)11-31-19-8-18(24)20(9-17(19)23)33(29,30)27-21-25-12-26-32-21/h2-5,8-9,12,14,16H,6-7,10-11H2,1H3,(H,25,26,27)/t14-,16-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 331n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323124
PNG
(2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)-4-((trans-4...)
Show SMILES Cc1ccc(cc1)C1CCNC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H22F2N4O3S2/c1-13-2-4-14(5-3-13)16-6-7-24-10-15(16)11-30-19-8-18(23)20(9-17(19)22)32(28,29)27-21-25-12-26-31-21/h2-5,8-9,12,15-16,24H,6-7,10-11H2,1H3,(H,25,26,27)/t15-,16?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 393n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323140
PNG
(Synthesis of 4-(((trans-5S)-2-(4-chlorophenyl)-5-h...)
Show SMILES O[C@@H]1CCC([C@H](COc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H20ClF2N3O4S2/c22-14-3-1-12(2-4-14)16-6-5-15(28)7-13(16)10-31-19-8-18(24)20(9-17(19)23)33(29,30)27-21-25-11-26-32-21/h1-4,8-9,11,13,15-16,28H,5-7,10H2,(H,25,26,27)/t13-,15+,16?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 426n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323110
PNG
(Synthesis of trans-3-((4(4-(N-(5-chlorothiazol-2-y...)
Show SMILES NC(=O)N1CCC([C@H](COc2cc(F)c(cc2F)S(=O)(=O)Nc2ncc(Cl)s2)C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C22H19ClF4N4O4S2/c23-20-8-29-22(36-20)30-37(33,34)19-7-16(26)18(6-17(19)27)35-10-12-9-31(21(28)32)4-3-13(12)11-1-2-14(24)15(25)5-11/h1-2,5-8,12-13H,3-4,9-10H2,(H2,28,32)(H,29,30)/t12-,13?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 436n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50024244
PNG
(CHEMBL3325523 | US9630929, Example 46)
Show SMILES Fc1ccc(cc1)[C@@H]1CCNC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H19F3N4O3S2/c21-14-3-1-12(2-4-14)15-5-6-24-9-13(15)10-30-18-7-17(23)19(8-16(18)22)32(28,29)27-20-25-11-26-31-20/h1-4,7-8,11,13,15,24H,5-6,9-10H2,(H,25,26,27)/t13-,15-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 550n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323095
PNG
(Synthesis of 2,5-difluoro-4-((trans-2-(4-fluorophe...)
Show SMILES Fc1ccc(cc1)C1CCCC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H20F3N3O3S2/c22-15-7-5-13(6-8-15)16-4-2-1-3-14(16)11-30-19-9-18(24)20(10-17(19)23)32(28,29)27-21-25-12-26-31-21/h5-10,12,14,16H,1-4,11H2,(H,25,26,27)/t14-,16?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323110
PNG
(Synthesis of trans-3-((4(4-(N-(5-chlorothiazol-2-y...)
Show SMILES NC(=O)N1CCC([C@H](COc2cc(F)c(cc2F)S(=O)(=O)Nc2ncc(Cl)s2)C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C22H19ClF4N4O4S2/c23-20-8-29-22(36-20)30-37(33,34)19-7-16(26)18(6-17(19)27)35-10-12-9-31(21(28)32)4-3-13(12)11-1-2-14(24)15(25)5-11/h1-2,5-8,12-13H,3-4,9-10H2,(H2,28,32)(H,29,30)/t12-,13?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM316503
PNG
(Synthesis of 2,5-difluoro-4-((trans-4-(4-fluorophe...)
Show SMILES Fc1ccc(cc1)C1CCNC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncccn1
Show InChI InChI=1S/C22H21F3N4O3S/c23-16-4-2-14(3-5-16)17-6-9-26-12-15(17)13-32-20-10-19(25)21(11-18(20)24)33(30,31)29-22-27-7-1-8-28-22/h1-5,7-8,10-11,15,17,26H,6,9,12-13H2,(H,27,28,29)/t15-,17?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323109
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)-1-(2,2,2...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CN(CC(F)(F)F)CCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C22H20ClF5N4O3S2/c23-15-3-1-13(2-4-15)16-5-6-32(11-22(26,27)28)9-14(16)10-35-19-7-18(25)20(8-17(19)24)37(33,34)31-21-29-12-30-36-21/h1-4,7-8,12,14,16H,5-6,9-11H2,(H,29,30,31)/t14-,16?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323082
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Cc1nsc(NS(=O)(=O)c2cc(F)c(OC[C@@H]3CNCCC3c3ccc(Cl)cc3)cc2F)n1
Show InChI InChI=1S/C21H21ClF2N4O3S2/c1-12-26-21(32-27-12)28-33(29,30)20-9-17(23)19(8-18(20)24)31-11-14-10-25-7-6-16(14)13-2-4-15(22)5-3-13/h2-5,8-9,14,16,25H,6-7,10-11H2,1H3,(H,26,27,28)/t14-,16?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323085
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Cc1cnc(NS(=O)(=O)c2cc(F)c(OC[C@@H]3CNCCC3c3ccc(Cl)cc3)cc2F)o1
Show InChI InChI=1S/C22H22ClF2N3O4S/c1-13-10-27-22(32-13)28-33(29,30)21-9-18(24)20(8-19(21)25)31-12-15-11-26-7-6-17(15)14-2-4-16(23)5-3-14/h2-5,8-10,15,17,26H,6-7,11-12H2,1H3,(H,27,28)/t15-,17?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323094
PNG
(Synthesis of 4-((cis-4-(4-chlorophenyl)piperidin-3...)
Show SMILES Fc1cc(c(F)cc1OC[C@H]1CNCCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H19ClF2N4O3S2/c21-14-3-1-12(2-4-14)15-5-6-24-9-13(15)10-30-18-7-17(23)19(8-16(18)22)32(28,29)27-20-25-11-26-31-20/h1-4,7-8,11,13,15,24H,5-6,9-10H2,(H,25,26,27)/t13-,15?/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50024216
PNG
(CHEMBL3325536 | US9630929, Example 86)
Show SMILES CN1CC[C@H]([C@H](COc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClF2N4O3S2/c1-28-7-6-16(13-2-4-15(22)5-3-13)14(10-28)11-31-19-8-18(24)20(9-17(19)23)33(29,30)27-21-25-12-26-32-21/h2-5,8-9,12,14,16H,6-7,10-11H2,1H3,(H,25,26,27)/t14-,16-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 550n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323093
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1cccnn1
Show InChI InChI=1S/C22H21ClF2N4O3S/c23-16-5-3-14(4-6-16)17-7-9-26-12-15(17)13-32-20-10-19(25)21(11-18(20)24)33(30,31)29-22-2-1-8-27-28-22/h1-6,8,10-11,15,17,26H,7,9,12-13H2,(H,28,29)/t15-,17?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323096
PNG
(Synthesis of trans-tert-butyl 3-((4-(N-(1,2,4-thia...)
Show SMILES CC(C)(C)OC(=O)N1CCC([C@H](COc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H27ClF2N4O5S2/c1-25(2,3)37-24(33)32-9-8-18(15-4-6-17(26)7-5-15)16(12-32)13-36-21-10-20(28)22(11-19(21)27)39(34,35)31-23-29-14-30-38-23/h4-7,10-11,14,16,18H,8-9,12-13H2,1-3H3,(H,29,30,31)/t16-,18?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50024244
PNG
(CHEMBL3325523 | US9630929, Example 46)
Show SMILES Fc1ccc(cc1)[C@@H]1CCNC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H19F3N4O3S2/c21-14-3-1-12(2-4-14)15-5-6-24-9-13(15)10-30-18-7-17(23)19(8-16(18)22)32(28,29)27-20-25-11-26-31-20/h1-4,7-8,11,13,15,24H,5-6,9-10H2,(H,25,26,27)/t13-,15-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 928n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323084
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Cc1cc(NS(=O)(=O)c2cc(F)c(OC[C@@H]3CNCCC3c3ccc(Cl)cc3)cc2F)no1
Show InChI InChI=1S/C22H22ClF2N3O4S/c1-13-8-22(27-32-13)28-33(29,30)21-10-18(24)20(9-19(21)25)31-12-15-11-26-7-6-17(15)14-2-4-16(23)5-3-14/h2-5,8-10,15,17,26H,6-7,11-12H2,1H3,(H,27,28)/t15-,17?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.89E+3n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323140
PNG
(Synthesis of 4-(((trans-5S)-2-(4-chlorophenyl)-5-h...)
Show SMILES O[C@@H]1CCC([C@H](COc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H20ClF2N3O4S2/c22-14-3-1-12(2-4-14)16-6-5-15(28)7-13(16)10-31-19-8-18(24)20(9-17(19)23)33(29,30)27-21-25-11-26-32-21/h1-4,8-9,11,13,15-16,28H,5-7,10H2,(H,25,26,27)/t13-,15+,16?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.04E+3n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323102
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Fc1cc(cc(F)c1OC[C@@H]1CNCCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H19ClF2N4O3S2/c21-14-3-1-12(2-4-14)16-5-6-24-9-13(16)10-30-19-17(22)7-15(8-18(19)23)32(28,29)27-20-25-11-26-31-20/h1-4,7-8,11,13,16,24H,5-6,9-10H2,(H,25,26,27)/t13-,16?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.32E+3n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323099
PNG
(Synthesis of (E)-4-((trans-4-(4-chlorophenyl)piper...)
Show SMILES Cn1cns\c1=N\S(=O)(=O)c1cc(F)c(OC[C@@H]2CNCCC2c2ccc(Cl)cc2)cc1F
Show InChI InChI=1S/C21H21ClF2N4O3S2/c1-28-12-26-32-21(28)27-33(29,30)20-9-17(23)19(8-18(20)24)31-11-14-10-25-7-6-16(14)13-2-4-15(22)5-3-13/h2-5,8-9,12,14,16,25H,6-7,10-11H2,1H3/b27-21+/t14-,16?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.08E+3n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323125
PNG
(Synthesis of 2,5-difluoro-4-((trans-6-oxo-4-(2,4,5...)
Show SMILES Fc1cc(F)c(cc1F)C1CC(=O)NC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H15F5N4O4S2/c21-12-3-14(23)13(22)1-11(12)10-2-19(30)26-6-9(10)7-33-17-4-16(25)18(5-15(17)24)35(31,32)29-20-27-8-28-34-20/h1,3-5,8-10H,2,6-7H2,(H,26,30)(H,27,28,29)/t9-,10?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.49E+3n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323120
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES CC(C)CNS(=O)(=O)c1cc(F)c(OC[C@@H]2CNCC[C@H]2c2ccc(Cl)cc2)cc1F
Show InChI InChI=1S/C22H27ClF2N2O3S/c1-14(2)11-27-31(28,29)22-10-19(24)21(9-20(22)25)30-13-16-12-26-8-7-18(16)15-3-5-17(23)6-4-15/h3-6,9-10,14,16,18,26-27H,7-8,11-13H2,1-2H3/t16-,18-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.90E+3n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM50024246
PNG
(CHEMBL3325526 | US9630929, Example 77)
Show SMILES Fc1cc(c(F)cc1OC[C@H]1CNCC[C@@H]1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H19ClF2N4O3S2/c21-14-3-1-12(2-4-14)15-5-6-24-9-13(15)10-30-18-7-17(23)19(8-16(18)22)32(28,29)27-20-25-11-26-31-20/h1-4,7-8,11,13,15,24H,5-6,9-10H2,(H,25,26,27)/t13-,15-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5.23E+3n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323084
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Cc1cc(NS(=O)(=O)c2cc(F)c(OC[C@@H]3CNCCC3c3ccc(Cl)cc3)cc2F)no1
Show InChI InChI=1S/C22H22ClF2N3O4S/c1-13-8-22(27-32-13)28-33(29,30)21-10-18(24)20(9-19(21)25)31-12-15-11-26-7-6-17(15)14-2-4-16(23)5-3-14/h2-5,8-10,15,17,26H,6-7,11-12H2,1H3,(H,27,28)/t15-,17?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM50024246
PNG
(CHEMBL3325526 | US9630929, Example 77)
Show SMILES Fc1cc(c(F)cc1OC[C@H]1CNCC[C@@H]1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H19ClF2N4O3S2/c21-14-3-1-12(2-4-14)15-5-6-24-9-13(15)10-30-18-7-17(23)19(8-16(18)22)32(28,29)27-20-25-11-26-31-20/h1-4,7-8,11,13,15,24H,5-6,9-10H2,(H,25,26,27)/t13-,15-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323122
PNG
(Synthesis of trans-3-((4-((1H-pyrazol-1-yl)sulfony...)
Show SMILES Fc1ccc(cc1)C1CCNC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)n1cccn1
Show InChI InChI=1S/C21H20F3N3O3S/c22-16-4-2-14(3-5-16)17-6-8-25-12-15(17)13-30-20-10-19(24)21(11-18(20)23)31(28,29)27-9-1-7-26-27/h1-5,7,9-11,15,17,25H,6,8,12-13H2/t15-,17?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7.22E+3n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM323122
PNG
(Synthesis of trans-3-((4-((1H-pyrazol-1-yl)sulfony...)
Show SMILES Fc1ccc(cc1)C1CCNC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)n1cccn1
Show InChI InChI=1S/C21H20F3N3O3S/c22-16-4-2-14(3-5-16)17-6-8-25-12-15(17)13-30-20-10-19(24)21(11-18(20)23)31(28,29)27-9-1-7-26-27/h1-5,7,9-11,15,17,25H,6,8,12-13H2/t15-,17?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7.53E+3n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM323120
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES CC(C)CNS(=O)(=O)c1cc(F)c(OC[C@@H]2CNCC[C@H]2c2ccc(Cl)cc2)cc1F
Show InChI InChI=1S/C22H27ClF2N2O3S/c1-14(2)11-27-31(28,29)22-10-19(24)21(9-20(22)25)30-13-16-12-26-8-7-18(16)15-3-5-17(23)6-4-15/h3-6,9-10,14,16,18,26-27H,7-8,11-13H2,1-2H3/t16-,18-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7.56E+3n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323100
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES CN(c1ncns1)S(=O)(=O)c1cc(F)c(OC[C@@H]2CNCCC2c2ccc(Cl)cc2)cc1F
Show InChI InChI=1S/C21H21ClF2N4O3S2/c1-28(21-26-12-27-32-21)33(29,30)20-9-17(23)19(8-18(20)24)31-11-14-10-25-7-6-16(14)13-2-4-15(22)5-3-13/h2-5,8-9,12,14,16,25H,6-7,10-11H2,1H3/t14-,16?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7.88E+3n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323117
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES NS(=O)(=O)c1cc(F)c(OC[C@@H]2CNCCC2c2ccc(Cl)cc2)cc1F
Show InChI InChI=1S/C18H19ClF2N2O3S/c19-13-3-1-11(2-4-13)14-5-6-23-9-12(14)10-26-17-7-16(21)18(8-15(17)20)27(22,24)25/h1-4,7-8,12,14,23H,5-6,9-10H2,(H2,22,24,25)/t12-,14?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM323139
PNG
(Synthesis of 4-((trans-2-(4-chlorophenyl)-5-oxocyc...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CC(=O)CC[C@H]1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H18ClF2N3O4S2/c22-14-3-1-12(2-4-14)16-6-5-15(28)7-13(16)10-31-19-8-18(24)20(9-17(19)23)33(29,30)27-21-25-11-26-32-21/h1-4,8-9,11,13,16H,5-7,10H2,(H,25,26,27)/t13-,16-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM50024132
PNG
(CHEMBL3325530 | US9630929, Example 47)
Show SMILES Fc1ccc(cc1)C1CCNCC1(F)COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H18F4N4O3S2/c21-13-3-1-12(2-4-13)14-5-6-25-9-20(14,24)10-31-17-7-16(23)18(8-15(17)22)33(29,30)28-19-26-11-27-32-19/h1-4,7-8,11,14,25H,5-6,9-10H2,(H,26,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM323086
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Clc1ccc(cc1)C1CCNC[C@H]1COc1ccc(cc1C#N)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H20ClN5O3S2/c22-17-3-1-14(2-4-17)19-7-8-24-11-16(19)12-30-20-6-5-18(9-15(20)10-23)32(28,29)27-21-25-13-26-31-21/h1-6,9,13,16,19,24H,7-8,11-12H2,(H,25,26,27)/t16-,19?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM323089
PNG
(Synthesis of N-(5-chlorothiazol-2-yl)-4-(trans-4-(...)
Show SMILES Fc1ccc(cc1F)C1CCNC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncc(Cl)s1
Show InChI InChI=1S/C21H18ClF4N3O3S2/c22-20-9-28-21(33-20)29-34(30,31)19-7-16(25)18(6-17(19)26)32-10-12-8-27-4-3-13(12)11-1-2-14(23)15(24)5-11/h1-2,5-7,9,12-13,27H,3-4,8,10H2,(H,28,29)/t12-,13?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM316478
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H19ClF2N4O3S2/c21-14-3-1-12(2-4-14)15-5-6-24-9-13(15)10-30-18-7-17(23)19(8-16(18)22)32(28,29)27-20-25-11-26-31-20/h1-4,7-8,11,13,15,24H,5-6,9-10H2,(H,25,26,27)/t13-,15?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM323110
PNG
(Synthesis of trans-3-((4(4-(N-(5-chlorothiazol-2-y...)
Show SMILES NC(=O)N1CCC([C@H](COc2cc(F)c(cc2F)S(=O)(=O)Nc2ncc(Cl)s2)C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C22H19ClF4N4O4S2/c23-20-8-29-22(36-20)30-37(33,34)19-7-16(26)18(6-17(19)27)35-10-12-9-31(21(28)32)4-3-13(12)11-1-2-14(24)15(25)5-11/h1-2,5-8,12-13H,3-4,9-10H2,(H2,28,32)(H,29,30)/t12-,13?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM323121
PNG
(Synthesis of 4-((trans-4-(4-chloro-3-fluorophenyl(...)
Show SMILES Fc1cc(ccc1Cl)C1CCNC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H18ClF3N4O3S2/c21-14-2-1-11(5-15(14)22)13-3-4-25-8-12(13)9-31-18-6-17(24)19(7-16(18)23)33(29,30)28-20-26-10-27-32-20/h1-2,5-7,10,12-13,25H,3-4,8-9H2,(H,26,27,28)/t12-,13?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM323135
PNG
(Synthesis of 2,5-difluoro-4-((trans-4-(4-fluoro-3-...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(F)c(c1)C(F)(F)F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H18F6N4O3S2/c22-15-2-1-11(5-14(15)21(25,26)27)13-3-4-28-8-12(13)9-34-18-6-17(24)19(7-16(18)23)36(32,33)31-20-29-10-30-35-20/h1-2,5-7,10,12-13,28H,3-4,8-9H2,(H,29,30,31)/t12-,13?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM323140
PNG
(Synthesis of 4-(((trans-5S)-2-(4-chlorophenyl)-5-h...)
Show SMILES O[C@@H]1CCC([C@H](COc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H20ClF2N3O4S2/c22-14-3-1-12(2-4-14)16-6-5-15(28)7-13(16)10-31-19-8-18(24)20(9-17(19)23)33(29,30)27-21-25-11-26-32-21/h1-4,8-9,11,13,15-16,28H,5-7,10H2,(H,25,26,27)/t13-,15+,16?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323123
PNG
(Synthesis of N-((4-((trans-4-(4-chlorophenyl)piper...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(Cl)cc1)S(=O)(=O)NC(=O)c1ccccn1
Show InChI InChI=1S/C24H22ClF2N3O4S/c25-17-6-4-15(5-7-17)18-8-10-28-13-16(18)14-34-22-11-20(27)23(12-19(22)26)35(32,33)30-24(31)21-3-1-2-9-29-21/h1-7,9,11-12,16,18,28H,8,10,13-14H2,(H,30,31)/t16-,18?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM316478
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H19ClF2N4O3S2/c21-14-3-1-12(2-4-14)15-5-6-24-9-13(15)10-30-18-7-17(23)19(8-16(18)22)32(28,29)27-20-25-11-26-31-20/h1-4,7-8,11,13,15,24H,5-6,9-10H2,(H,25,26,27)/t13-,15?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM50024132
PNG
(CHEMBL3325530 | US9630929, Example 47)
Show SMILES Fc1ccc(cc1)C1CCNCC1(F)COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H18F4N4O3S2/c21-13-3-1-12(2-4-13)14-5-6-25-9-20(14,24)10-31-17-7-16(23)18(8-15(17)22)33(29,30)28-19-26-11-27-32-19/h1-4,7-8,11,14,25H,5-6,9-10H2,(H,26,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM50024217
PNG
(CHEMBL3325537 | US9630929, Example 85)
Show SMILES CN1CC[C@@H]([C@@H](COc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClF2N4O3S2/c1-28-7-6-16(13-2-4-15(22)5-3-13)14(10-28)11-31-19-8-18(24)20(9-17(19)23)33(29,30)27-21-25-12-26-32-21/h2-5,8-9,12,14,16H,6-7,10-11H2,1H3,(H,25,26,27)/t14-,16-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM323109
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)-1-(2,2,2...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CN(CC(F)(F)F)CCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C22H20ClF5N4O3S2/c23-15-3-1-13(2-4-15)16-5-6-32(11-22(26,27)28)9-14(16)10-35-19-7-18(25)20(8-17(19)24)37(33,34)31-21-29-12-30-36-21/h1-4,7-8,12,14,16H,5-6,9-11H2,(H,29,30,31)/t14-,16?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM323116
PNG
(Synthesis of 2,5-difluoro-4-((trans-4-(4-methoxyph...)
Show SMILES COc1ccc(cc1)C1CCNC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H22F2N4O4S2/c1-30-15-4-2-13(3-5-15)16-6-7-24-10-14(16)11-31-19-8-18(23)20(9-17(19)22)33(28,29)27-21-25-12-26-32-21/h2-5,8-9,12,14,16,24H,6-7,10-11H2,1H3,(H,25,26,27)/t14-,16?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM323132
PNG
(Synthesis of 2,5-difluoro-N-(1,2,4-thiadiazol-5-yl...)
Show SMILES Fc1cc(F)c(cc1F)C1CCNC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H17F5N4O3S2/c21-13-4-15(23)14(22)3-12(13)11-1-2-26-7-10(11)8-32-18-5-17(25)19(6-16(18)24)34(30,31)29-20-27-9-28-33-20/h3-6,9-11,26H,1-2,7-8H2,(H,27,28,29)/t10-,11?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM323140
PNG
(Synthesis of 4-(((trans-5S)-2-(4-chlorophenyl)-5-h...)
Show SMILES O[C@@H]1CCC([C@H](COc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H20ClF2N3O4S2/c22-14-3-1-12(2-4-14)16-6-5-15(28)7-13(16)10-31-19-8-18(24)20(9-17(19)23)33(29,30)27-21-25-11-26-32-21/h1-4,8-9,11,13,15-16,28H,5-7,10H2,(H,25,26,27)/t13-,15+,16?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM323142
PNG
(Synthesis of 44(1-(4-chlorophenyl)piperazin-2-yl)m...)
Show SMILES Fc1cc(c(F)cc1OCC1CNCCN1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C19H18ClF2N5O3S2/c20-12-1-3-13(4-2-12)27-6-5-23-9-14(27)10-30-17-7-16(22)18(8-15(17)21)32(28,29)26-19-24-11-25-31-19/h1-4,7-8,11,14,23H,5-6,9-10H2,(H,24,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323114
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES FC(F)(F)CNS(=O)(=O)c1ccc(OC[C@@H]2CNCCC2c2ccc(Cl)cc2)c(c1)C#N
Show InChI InChI=1S/C21H21ClF3N3O3S/c22-17-3-1-14(2-4-17)19-7-8-27-11-16(19)12-31-20-6-5-18(9-15(20)10-26)32(29,30)28-13-21(23,24)25/h1-6,9,16,19,27-28H,7-8,11-13H2/t16-,19?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM316481
PNG
(Synthesis of 2,5-difluoro-4-((trans-4-(4-fluorophe...)
Show SMILES Fc1ccc(cc1)C1CCNC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H19F3N4O3S2/c21-14-3-1-12(2-4-14)15-5-6-24-9-13(15)10-30-18-7-17(23)19(8-16(18)22)32(28,29)27-20-25-11-26-31-20/h1-4,7-8,11,13,15,24H,5-6,9-10H2,(H,25,26,27)/t13-,15?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM323087
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Fc1cc(ccc1OC[C@@H]1CNCCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H20ClFN4O3S2/c21-15-3-1-13(2-4-15)17-7-8-23-10-14(17)11-29-19-6-5-16(9-18(19)22)31(27,28)26-20-24-12-25-30-20/h1-6,9,12,14,17,23H,7-8,10-11H2,(H,24,25,26)/t14-,17?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM323089
PNG
(Synthesis of N-(5-chlorothiazol-2-yl)-4-(trans-4-(...)
Show SMILES Fc1ccc(cc1F)C1CCNC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncc(Cl)s1
Show InChI InChI=1S/C21H18ClF4N3O3S2/c22-20-9-28-21(33-20)29-34(30,31)19-7-16(25)18(6-17(19)26)32-10-12-8-27-4-3-13(12)11-1-2-14(23)15(24)5-11/h1-2,5-7,9,12-13,27H,3-4,8,10H2,(H,28,29)/t12-,13?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM323110
PNG
(Synthesis of trans-3-((4(4-(N-(5-chlorothiazol-2-y...)
Show SMILES NC(=O)N1CCC([C@H](COc2cc(F)c(cc2F)S(=O)(=O)Nc2ncc(Cl)s2)C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C22H19ClF4N4O4S2/c23-20-8-29-22(36-20)30-37(33,34)19-7-16(26)18(6-17(19)27)35-10-12-9-31(21(28)32)4-3-13(12)11-1-2-14(24)15(25)5-11/h1-2,5-8,12-13H,3-4,9-10H2,(H2,28,32)(H,29,30)/t12-,13?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM323135
PNG
(Synthesis of 2,5-difluoro-4-((trans-4-(4-fluoro-3-...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(F)c(c1)C(F)(F)F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H18F6N4O3S2/c22-15-2-1-11(5-14(15)21(25,26)27)13-3-4-28-8-12(13)9-34-18-6-17(24)19(7-16(18)23)36(32,33)31-20-29-10-30-35-20/h1-2,5-7,10,12-13,28H,3-4,8-9H2,(H,29,30,31)/t12-,13?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323111
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES CC(C)NS(=O)(=O)c1ccc(OC[C@@H]2CNCCC2c2ccc(Cl)cc2)c(c1)C#N
Show InChI InChI=1S/C22H26ClN3O3S/c1-15(2)26-30(27,28)20-7-8-22(17(11-20)12-24)29-14-18-13-25-10-9-21(18)16-3-5-19(23)6-4-16/h3-8,11,15,18,21,25-26H,9-10,13-14H2,1-2H3/t18-,21?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323130
PNG
(Synthesis of N-((4-((trans-4-(4-chlorophenyl)piper...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(Cl)cc1)S(=O)(=O)NC(=O)c1ccccc1
Show InChI InChI=1S/C25H23ClF2N2O4S/c26-19-8-6-16(7-9-19)20-10-11-29-14-18(20)15-34-23-12-22(28)24(13-21(23)27)35(32,33)30-25(31)17-4-2-1-3-5-17/h1-9,12-13,18,20,29H,10-11,14-15H2,(H,30,31)/t18-,20?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM316478
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H19ClF2N4O3S2/c21-14-3-1-12(2-4-14)15-5-6-24-9-13(15)10-30-18-7-17(23)19(8-16(18)22)32(28,29)27-20-25-11-26-31-20/h1-4,7-8,11,13,15,24H,5-6,9-10H2,(H,25,26,27)/t13-,15?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM50024216
PNG
(CHEMBL3325536 | US9630929, Example 86)
Show SMILES CN1CC[C@H]([C@H](COc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClF2N4O3S2/c1-28-7-6-16(13-2-4-15(22)5-3-13)14(10-28)11-31-19-8-18(24)20(9-17(19)23)33(29,30)27-21-25-12-26-32-21/h2-5,8-9,12,14,16H,6-7,10-11H2,1H3,(H,25,26,27)/t14-,16-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM50024216
PNG
(CHEMBL3325536 | US9630929, Example 86)
Show SMILES CN1CC[C@H]([C@H](COc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClF2N4O3S2/c1-28-7-6-16(13-2-4-15(22)5-3-13)14(10-28)11-31-19-8-18(24)20(9-17(19)23)33(29,30)27-21-25-12-26-32-21/h2-5,8-9,12,14,16H,6-7,10-11H2,1H3,(H,25,26,27)/t14-,16-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323131
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES CC(C)NC(=O)NS(=O)(=O)c1cc(F)c(OC[C@@H]2CNCCC2c2ccc(Cl)cc2)cc1F
Show InChI InChI=1S/C22H26ClF2N3O4S/c1-13(2)27-22(29)28-33(30,31)21-10-18(24)20(9-19(21)25)32-12-15-11-26-8-7-17(15)14-3-5-16(23)6-4-14/h3-6,9-10,13,15,17,26H,7-8,11-12H2,1-2H3,(H2,27,28,29)/t15-,17?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM323097
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)-1-methyl...)
Show SMILES CN1CCC([C@H](COc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClF2N4O3S2/c1-28-7-6-16(13-2-4-15(22)5-3-13)14(10-28)11-31-19-8-18(24)20(9-17(19)23)33(29,30)27-21-25-12-26-32-21/h2-5,8-9,12,14,16H,6-7,10-11H2,1H3,(H,25,26,27)/t14-,16?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM316478
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H19ClF2N4O3S2/c21-14-3-1-12(2-4-14)15-5-6-24-9-13(15)10-30-18-7-17(23)19(8-16(18)22)32(28,29)27-20-25-11-26-31-20/h1-4,7-8,11,13,15,24H,5-6,9-10H2,(H,25,26,27)/t13-,15?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM323108
PNG
(Synthesis of 2,5-difluoro-4-((trans-4-(4-fluorophe...)
Show SMILES Fc1ccc(cc1)C1CC(=O)NC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H17F3N4O4S2/c21-13-3-1-11(2-4-13)14-5-19(28)24-8-12(14)9-31-17-6-16(23)18(7-15(17)22)33(29,30)27-20-25-10-26-32-20/h1-4,6-7,10,12,14H,5,8-9H2,(H,24,28)(H,25,26,27)/t12-,14?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM323109
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)-1-(2,2,2...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CN(CC(F)(F)F)CCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C22H20ClF5N4O3S2/c23-15-3-1-13(2-4-15)16-5-6-32(11-22(26,27)28)9-14(16)10-35-19-7-18(25)20(8-17(19)24)37(33,34)31-21-29-12-30-36-21/h1-4,7-8,12,14,16H,5-6,9-11H2,(H,29,30,31)/t14-,16?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM323124
PNG
(2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)-4-((trans-4...)
Show SMILES Cc1ccc(cc1)C1CCNC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H22F2N4O3S2/c1-13-2-4-14(5-3-13)16-6-7-24-10-15(16)11-30-19-8-18(23)20(9-17(19)22)32(28,29)27-21-25-12-26-31-21/h2-5,8-9,12,15-16,24H,6-7,10-11H2,1H3,(H,25,26,27)/t15-,16?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM323086
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Clc1ccc(cc1)C1CCNC[C@H]1COc1ccc(cc1C#N)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H20ClN5O3S2/c22-17-3-1-14(2-4-17)19-7-8-24-11-16(19)12-30-20-6-5-18(9-15(20)10-23)32(28,29)27-21-25-13-26-31-21/h1-6,9,13,16,19,24H,7-8,11-12H2,(H,25,26,27)/t16-,19?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM323097
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)-1-methyl...)
Show SMILES CN1CCC([C@H](COc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClF2N4O3S2/c1-28-7-6-16(13-2-4-15(22)5-3-13)14(10-28)11-31-19-8-18(24)20(9-17(19)23)33(29,30)27-21-25-12-26-32-21/h2-5,8-9,12,14,16H,6-7,10-11H2,1H3,(H,25,26,27)/t14-,16?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM323100
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES CN(c1ncns1)S(=O)(=O)c1cc(F)c(OC[C@@H]2CNCCC2c2ccc(Cl)cc2)cc1F
Show InChI InChI=1S/C21H21ClF2N4O3S2/c1-28(21-26-12-27-32-21)33(29,30)20-9-17(23)19(8-18(20)24)31-11-14-10-25-7-6-16(14)13-2-4-15(22)5-3-13/h2-5,8-9,12,14,16,25H,6-7,10-11H2,1H3/t14-,16?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM323108
PNG
(Synthesis of 2,5-difluoro-4-((trans-4-(4-fluorophe...)
Show SMILES Fc1ccc(cc1)C1CC(=O)NC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H17F3N4O4S2/c21-13-3-1-11(2-4-13)14-5-19(28)24-8-12(14)9-31-17-6-16(23)18(7-15(17)22)33(29,30)27-20-25-10-26-32-20/h1-4,6-7,10,12,14H,5,8-9H2,(H,24,28)(H,25,26,27)/t12-,14?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323112
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Clc1ccc(cc1)C1CCNC[C@H]1COc1ccc(cc1C#N)S(=O)(=O)NC1(CC1)C#N
Show InChI InChI=1S/C23H23ClN4O3S/c24-19-3-1-16(2-4-19)21-7-10-27-13-18(21)14-31-22-6-5-20(11-17(22)12-25)32(29,30)28-23(15-26)8-9-23/h1-6,11,18,21,27-28H,7-10,13-14H2/t18-,21?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM316481
PNG
(Synthesis of 2,5-difluoro-4-((trans-4-(4-fluorophe...)
Show SMILES Fc1ccc(cc1)C1CCNC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H19F3N4O3S2/c21-14-3-1-12(2-4-14)15-5-6-24-9-13(15)10-30-18-7-17(23)19(8-16(18)22)32(28,29)27-20-25-11-26-31-20/h1-4,7-8,11,13,15,24H,5-6,9-10H2,(H,25,26,27)/t13-,15?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM50024217
PNG
(CHEMBL3325537 | US9630929, Example 85)
Show SMILES CN1CC[C@@H]([C@@H](COc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClF2N4O3S2/c1-28-7-6-16(13-2-4-15(22)5-3-13)14(10-28)11-31-19-8-18(24)20(9-17(19)23)33(29,30)27-21-25-12-26-32-21/h2-5,8-9,12,14,16H,6-7,10-11H2,1H3,(H,25,26,27)/t14-,16-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM323113
PNG
(Synthesis of 4-((trans-4-(3,4-dichlorophenyl)piper...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(Cl)c(Cl)c1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H18Cl2F2N4O3S2/c21-14-2-1-11(5-15(14)22)13-3-4-25-8-12(13)9-31-18-6-17(24)19(7-16(18)23)33(29,30)28-20-26-10-27-32-20/h1-2,5-7,10,12-13,25H,3-4,8-9H2,(H,26,27,28)/t12-,13?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323129
PNG
(Synthesis of N-((4-((trans-4-(4-chlorophenyl)piper...)
Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCCC1c1ccc(Cl)cc1)S(=O)(=O)NC(=O)c1cccnc1
Show InChI InChI=1S/C24H22ClF2N3O4S/c25-18-5-3-15(4-6-18)19-7-9-29-13-17(19)14-34-22-10-21(27)23(11-20(22)26)35(32,33)30-24(31)16-2-1-8-28-12-16/h1-6,8,10-12,17,19,29H,7,9,13-14H2,(H,30,31)/t17-,19?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM323087
PNG
(Synthesis of 4-((trans-4-(4-chlorophenyl)piperidin...)
Show SMILES Fc1cc(ccc1OC[C@@H]1CNCCC1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H20ClFN4O3S2/c21-15-3-1-13(2-4-15)17-7-8-23-10-14(17)11-29-19-6-5-16(9-18(19)22)31(27,28)26-20-24-12-25-30-20/h1-6,9,12,14,17,23H,7-8,10-11H2,(H,24,25,26)/t14-,17?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM323127
PNG
(Synthesis of N-((4-((trans-4-(4-chlorophenyl)piper...)
Show SMILES CC(=O)NS(=O)(=O)c1cc(F)c(OC[C@@H]2CNCCC2c2ccc(Cl)cc2)cc1F
Show InChI InChI=1S/C20H21ClF2N2O4S/c1-12(26)25-30(27,28)20-9-17(22)19(8-18(20)23)29-11-14-10-24-7-6-16(14)13-2-4-15(21)5-3-13/h2-5,8-9,14,16,24H,6-7,10-11H2,1H3,(H,25,26)/t14-,16?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9630929 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%