BindingDB logo
myBDB logout

Patent code US9636337

Compile Data Set for Download or QSAR

Found 315 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM212837
PNG
(US9278960, 1-7 | US9636337, 1-7)
Show SMILES Cc1ccc2c(cc(nc2c1)C(N)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C17H13FN2O/c1-10-2-7-13-14(11-3-5-12(18)6-4-11)9-16(17(19)21)20-15(13)8-10/h2-9H,1H3,(H2,19,21)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 159n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM325727
PNG
(4-(2,6-dichloro-4-fluorophenyl)quinoline-2-carboxa...)
Show SMILES NC(=O)c1cc(-c2c(Cl)cc(F)cc2Cl)c2ccccc2n1
Show InChI InChI=1S/C16H9Cl2FN2O/c17-11-5-8(19)6-12(18)15(11)10-7-14(16(20)22)21-13-4-2-1-3-9(10)13/h1-7H,(H2,20,22)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 171n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM212842
PNG
(US9278960, 1-13 | US9663506, Example 1-13)
Show SMILES Cc1cscc1-c1cc(nc2ccccc12)C(N)=O
Show InChI InChI=1S/C15H12N2OS/c1-9-7-19-8-12(9)11-6-14(15(16)18)17-13-5-3-2-4-10(11)13/h2-8H,1H3,(H2,16,18)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 641n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM212853
PNG
(US9278960, 1-24 | US9663506, Example 1-24)
Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2ccccc2n1
Show InChI InChI=1S/C16H11FN2O/c17-11-7-5-10(6-8-11)13-9-15(16(18)20)19-14-4-2-1-3-12(13)14/h1-9H,(H2,18,20)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 169n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM212868
PNG
(US9278960, 2-15 | US9663506, Example 2-15)
Show SMILES CN1C(=O)N(Cc2ccc3c(cc(nc3c2)C(N)=O)-c2ccc(F)cc2)C(=O)C1(C)C
Show InChI InChI=1S/C23H21FN4O3/c1-23(2)21(30)28(22(31)27(23)3)12-13-4-9-16-17(14-5-7-15(24)8-6-14)11-19(20(25)29)26-18(16)10-13/h4-11H,12H2,1-3H3,(H2,25,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 64n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM212886
PNG
(US9278960, 2-33 | US9663506, Example 2-33)
Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(CN3CCCCS3(=O)=O)cc2n1
Show InChI InChI=1S/C21H20FN3O3S/c22-16-6-4-15(5-7-16)18-12-20(21(23)26)24-19-11-14(3-8-17(18)19)13-25-9-1-2-10-29(25,27)28/h3-8,11-12H,1-2,9-10,13H2,(H2,23,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 42n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM213149
PNG
(US9278960, 3-7 | US9663506, Example 3-6)
Show SMILES CCC(O)(c1nnn(Cc2ccc3c(cc(nc3c2)C(N)=O)-c2ccc(F)cc2)n1)C(F)(F)F
Show InChI InChI=1S/C22H18F4N6O2/c1-2-21(34,22(24,25)26)20-29-31-32(30-20)11-12-3-8-15-16(13-4-6-14(23)7-5-13)10-18(19(27)33)28-17(15)9-12/h3-10,34H,2,11H2,1H3,(H2,27,33)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 21n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM212894
PNG
(US9278960, 3-6 | US9663506, Example 3-7)
Show SMILES CCC(O)(c1nnnn1Cc1ccc2c(cc(nc2c1)C(N)=O)-c1ccc(F)cc1)C(F)(F)F
Show InChI InChI=1S/C22H18F4N6O2/c1-2-21(34,22(24,25)26)20-29-30-31-32(20)11-12-3-8-15-16(13-4-6-14(23)7-5-13)10-18(19(27)33)28-17(15)9-12/h3-10,34H,2,11H2,1H3,(H2,27,33)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 24n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM212900
PNG
(US9278960, 3-19 | US9663506, Example 3-19)
Show SMILES CC[C@](O)(c1cn(Cc2ccc3c(cc(nc3c2)C(N)=O)-c2cccnc2F)nn1)C(F)(F)F
Show InChI InChI=1S/C22H18F4N6O2/c1-2-21(34,22(24,25)26)18-11-32(31-30-18)10-12-5-6-13-15(14-4-3-7-28-19(14)23)9-17(20(27)33)29-16(13)8-12/h3-9,11,34H,2,10H2,1H3,(H2,27,33)/t21-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 112n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM212905
PNG
(US9278960, 3-24 | US9663506, Example 3-24)
Show SMILES COC(=O)c1cnn(Cc2ccc3c(cc(nc3c2)C(N)=O)-c2ccc(F)cc2)c1
Show InChI InChI=1S/C22H17FN4O3/c1-30-22(29)15-10-25-27(12-15)11-13-2-7-17-18(14-3-5-16(23)6-4-14)9-20(21(24)28)26-19(17)8-13/h2-10,12H,11H2,1H3,(H2,24,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 31n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM212909
PNG
(US9278960, 3-28 | US9663506, Example 3-28)
Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(Cn3cc(nn3)C(O)=O)cc2n1
Show InChI InChI=1S/C20H14FN5O3/c21-13-4-2-12(3-5-13)15-8-17(19(22)27)23-16-7-11(1-6-14(15)16)9-26-10-18(20(28)29)24-25-26/h1-8,10H,9H2,(H2,22,27)(H,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 84n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM212930
PNG
(US9278960, 3-49 | US9663506, Example 3-49)
Show SMILES CCC(O)(c1cn(Cc2ccc3c(cc(nc3c2)C(N)=O)-c2ccc(OC)c(F)c2)cn1)C(F)(F)F
Show InChI InChI=1S/C25H22F4N4O3/c1-3-24(35,25(27,28)29)22-12-33(13-31-22)11-14-4-6-16-17(10-20(23(30)34)32-19(16)8-14)15-5-7-21(36-2)18(26)9-15/h4-10,12-13,35H,3,11H2,1-2H3,(H2,30,34)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 16n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM212942
PNG
(US9278960, 4-26 | US9663506, Example 4-26)
Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(CN3CC[C@@H](F)C3)cc2n1
Show InChI InChI=1S/C21H19F2N3O/c22-15-4-2-14(3-5-15)18-10-20(21(24)27)25-19-9-13(1-6-17(18)19)11-26-8-7-16(23)12-26/h1-6,9-10,16H,7-8,11-12H2,(H2,24,27)/t16-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 118n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM212952
PNG
(US9278960, 4-36 | US9663506, Example 4-36)
Show SMILES NC(=O)C1CC(O)CN1Cc1ccc2c(cc(nc2c1)C(N)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C22H21FN4O3/c23-14-4-2-13(3-5-14)17-9-19(21(24)29)26-18-7-12(1-6-16(17)18)10-27-11-15(28)8-20(27)22(25)30/h1-7,9,15,20,28H,8,10-11H2,(H2,24,29)(H2,25,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 274n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM212974
PNG
(US9278960, 4-58 | US9663506, Example 4-58)
Show SMILES COCC1CN(Cc2ccc3c(cc(nc3c2)C(N)=O)-c2cnn(C)c2)CCO1
Show InChI InChI=1S/C21H25N5O3/c1-25-11-15(9-23-25)18-8-20(21(22)27)24-19-7-14(3-4-17(18)19)10-26-5-6-29-16(12-26)13-28-2/h3-4,7-9,11,16H,5-6,10,12-13H2,1-2H3,(H2,22,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 163n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM212982
PNG
(US9278960, 4-66 | US9663506, Example 4-66)
Show SMILES C[C@@H]1CN(Cc2ccc3c(cc(nc3c2)C(N)=O)-c2cnn(C)c2)C[C@H](O1)C(F)(F)F
Show InChI InChI=1S/C21H22F3N5O2/c1-12-8-29(11-19(31-12)21(22,23)24)9-13-3-4-15-16(14-7-26-28(2)10-14)6-18(20(25)30)27-17(15)5-13/h3-7,10,12,19H,8-9,11H2,1-2H3,(H2,25,30)/t12-,19+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 16n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM212986
PNG
(US9278960, 4-70 | US9663506, Example 4-70)
Show SMILES Cn1cc(cn1)-c1cc(nc2cc(CN3CCC(CC3)C(F)(F)F)ccc12)C(N)=O
Show InChI InChI=1S/C21H22F3N5O/c1-28-12-14(10-26-28)17-9-19(20(25)30)27-18-8-13(2-3-16(17)18)11-29-6-4-15(5-7-29)21(22,23)24/h2-3,8-10,12,15H,4-7,11H2,1H3,(H2,25,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 114n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM212998
PNG
(US9278960, 4-82 | US9663506, Example 4-82)
Show SMILES NC(=O)c1cc(-c2cnn(c2)C2CC2)c2ccc(CN3CCOC(C3)C(F)(F)F)cc2n1
Show InChI InChI=1S/C22H22F3N5O2/c23-22(24,25)20-12-29(5-6-32-20)10-13-1-4-16-17(8-19(21(26)31)28-18(16)7-13)14-9-27-30(11-14)15-2-3-15/h1,4,7-9,11,15,20H,2-3,5-6,10,12H2,(H2,26,31)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 188n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM213000
PNG
(US9278960, 4-84 | US9663506, Example 4-84)
Show SMILES NC(=O)c1cc(-c2cnn(c2)C(F)F)c2ccc(CN3CCOC(C3)C(F)(F)F)cc2n1
Show InChI InChI=1S/C20H18F5N5O2/c21-19(22)30-9-12(7-27-30)14-6-16(18(26)31)28-15-5-11(1-2-13(14)15)8-29-3-4-32-17(10-29)20(23,24)25/h1-2,5-7,9,17,19H,3-4,8,10H2,(H2,26,31)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 11n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM213012
PNG
(US9278960, 4-96 | US9663506, Example 4-96)
Show SMILES Cn1cc(cn1)-c1cc(nc2cc(CN3C[C@@H](OCC3(C)C)C(F)(F)F)ccc12)C(N)=O
Show InChI InChI=1S/C22H24F3N5O2/c1-21(2)12-32-19(22(23,24)25)11-30(21)9-13-4-5-15-16(14-8-27-29(3)10-14)7-18(20(26)31)28-17(15)6-13/h4-8,10,19H,9,11-12H2,1-3H3,(H2,26,31)/t19-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 8n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM213027
PNG
(US9278960, 4-111 | US9663506, Example 4-111)
Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(CN3CCNC(CF)C3)cc2n1
Show InChI InChI=1S/C22H22F2N4O/c23-11-17-13-28(8-7-26-17)12-14-1-6-18-19(15-2-4-16(24)5-3-15)10-21(22(25)29)27-20(18)9-14/h1-6,9-10,17,26H,7-8,11-13H2,(H2,25,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 80n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM213028
PNG
(US9278960, 4-112 | US9278960, 4-113 | US9278960, 4...)
Show SMILES CC1CN(Cc2ccc3c(cc(nc3c2)C(N)=O)-c2ccc(F)cc2)CC(N1)C(F)(F)F
Show InChI InChI=1S/C23H22F4N4O/c1-13-10-31(12-21(29-13)23(25,26)27)11-14-2-7-17-18(15-3-5-16(24)6-4-15)9-20(22(28)32)30-19(17)8-14/h2-9,13,21,29H,10-12H2,1H3,(H2,28,32)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 24n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM213033
PNG
(US9278960, 4-117 | US9636337, 4-117)
Show SMILES C[C@@H]1CN(Cc2ccc3c(cc(nc3c2)C(N)=O)-c2cnc(s2)C(F)F)C[C@@H](O1)C(F)(F)F
Show InChI InChI=1S/C21H19F5N4O2S/c1-10-7-30(9-17(32-10)21(24,25)26)8-11-2-3-12-13(16-6-28-20(33-16)18(22)23)5-15(19(27)31)29-14(12)4-11/h2-6,10,17-18H,7-9H2,1H3,(H2,27,31)/t10-,17-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 53n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM213038
PNG
(US9278960, 4-122 | US9663506, Example 4-122)
Show SMILES Cn1cc(cn1)-c1cc(nc2cc(CN3CCC[C@H](O)C3)ccc12)C(N)=O
Show InChI InChI=1S/C20H23N5O2/c1-24-11-14(9-22-24)17-8-19(20(21)27)23-18-7-13(4-5-16(17)18)10-25-6-2-3-15(26)12-25/h4-5,7-9,11,15,26H,2-3,6,10,12H2,1H3,(H2,21,27)/t15-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 931n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM213041
PNG
(US9278960, 4-125 | US9636337, 4-125)
Show SMILES C[C@@H]1CN(Cc2ccc3c(cc(nc3c2)C(N)=O)-c2ncc(C)s2)C[C@@H](O1)C(F)(F)F
Show InChI InChI=1S/C21H21F3N4O2S/c1-11-8-28(10-18(30-11)21(22,23)24)9-13-3-4-14-15(20-26-7-12(2)31-20)6-17(19(25)29)27-16(14)5-13/h3-7,11,18H,8-10H2,1-2H3,(H2,25,29)/t11-,18-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 76n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM213060
PNG
(US9278960, 6-7 | US9663506, Example 6-7)
Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(Cc3ccnc(CO)c3)cc2n1
Show InChI InChI=1S/C23H18FN3O2/c24-17-4-2-16(3-5-17)20-12-22(23(25)29)27-21-11-14(1-6-19(20)21)9-15-7-8-26-18(10-15)13-28/h1-8,10-12,28H,9,13H2,(H2,25,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 8n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM213067
PNG
(US9278960, 6-14 | US9663506, Example 6-14)
Show SMILES COc1cc(Cc2ccc3c(cc(nc3c2)C(N)=O)-c2ccc(F)cc2)ccn1
Show InChI InChI=1S/C23H18FN3O2/c1-29-22-12-15(8-9-26-22)10-14-2-7-18-19(16-3-5-17(24)6-4-16)13-21(23(25)28)27-20(18)11-14/h2-9,11-13H,10H2,1H3,(H2,25,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 18n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM213068
PNG
(US9278960, 6-15 | US9663506, Example 6-15)
Show SMILES Cn1cc(cn1)-c1cc(nc2cc(Cc3cnc(Cl)nc3)ccc12)C(N)=O
Show InChI InChI=1S/C19H15ClN6O/c1-26-10-13(9-24-26)15-6-17(18(21)27)25-16-5-11(2-3-14(15)16)4-12-7-22-19(20)23-8-12/h2-3,5-10H,4H2,1H3,(H2,21,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 34n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM213076
PNG
(US9278960, 6-23 | US9663506, Example 6-23)
Show SMILES Cn1cc(cn1)-c1cc(nc2cc(Cc3cccc(n3)C(F)(F)F)ccc12)C(N)=O
Show InChI InChI=1S/C21H16F3N5O/c1-29-11-13(10-26-29)16-9-18(20(25)30)28-17-8-12(5-6-15(16)17)7-14-3-2-4-19(27-14)21(22,23)24/h2-6,8-11H,7H2,1H3,(H2,25,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 28n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM213084
PNG
(US9278960, 7-22 | US9636337, 7-22)
Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2c(F)cc(CN3C(=O)CCC3=O)cc2n1
Show InChI InChI=1S/C21H15F2N3O3/c22-13-3-1-12(2-4-13)14-9-17(21(24)29)25-16-8-11(7-15(23)20(14)16)10-26-18(27)5-6-19(26)28/h1-4,7-9H,5-6,10H2,(H2,24,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 74n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM213089
PNG
(US9278960, 7-27 | US9636337, 7-27)
Show SMILES Cn1cc(cn1)-c1cc(nc2c(F)c(CN3CCC(F)CC3)ccc12)C(N)=O
Show InChI InChI=1S/C20H21F2N5O/c1-26-10-13(9-24-26)16-8-17(20(23)28)25-19-15(16)3-2-12(18(19)22)11-27-6-4-14(21)5-7-27/h2-3,8-10,14H,4-7,11H2,1H3,(H2,23,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 169n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM213097
PNG
(US9278960, 7-35 | US9636337, 7-35)
Show SMILES COc1cc(Cc2ccc3c(cc(nc3c2F)C(N)=O)-c2cnn(C)c2)cc(C)n1
Show InChI InChI=1S/C22H20FN5O2/c1-12-6-13(8-19(26-12)30-3)7-14-4-5-16-17(15-10-25-28(2)11-15)9-18(22(24)29)27-21(16)20(14)23/h4-6,8-11H,7H2,1-3H3,(H2,24,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 14n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM213152
PNG
(US9278960, 8-2 | US9636337, 8-2)
Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(cc2n1)[C@H](O)Cc1ccc(Cl)nc1
Show InChI InChI=1S/C23H17ClFN3O2/c24-22-8-1-13(12-27-22)9-21(29)15-4-7-17-18(14-2-5-16(25)6-3-14)11-20(23(26)30)28-19(17)10-15/h1-8,10-12,21,29H,9H2,(H2,26,30)/t21-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 15n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM213118
PNG
(US9278960, 8-25 | US9278960, 8-26 | US9636337, 8-2...)
Show SMILES CC(Cc1ccc(C)nc1)c1ccc2c(cc(nc2c1)C(N)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C25H22FN3O/c1-15(11-17-4-3-16(2)28-14-17)19-7-10-21-22(18-5-8-20(26)9-6-18)13-24(25(27)30)29-23(21)12-19/h3-10,12-15H,11H2,1-2H3,(H2,27,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 19n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM213113
PNG
(US9278960, 8-20 | US9278960, 8-27 | US9278960, 8-2...)
Show SMILES COc1ccc(cc1)-c1cc(nc2cc(ccc12)C(O)Cc1ccc(Cl)nc1)C(N)=O
Show InChI InChI=1S/C24H20ClN3O3/c1-31-17-6-3-15(4-7-17)19-12-21(24(26)30)28-20-11-16(5-8-18(19)20)22(29)10-14-2-9-23(25)27-13-14/h2-9,11-13,22,29H,10H2,1H3,(H2,26,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM213122
PNG
(US9278960, 8-29 | US9636337, 8-29)
Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(CCc3cnc(C)nc3)ccc12)C(N)=O
Show InChI InChI=1S/C24H21FN4O2/c1-14-27-12-16(13-28-14)4-3-15-5-7-19-20(11-23(24(26)30)29-22(19)9-15)18-8-6-17(31-2)10-21(18)25/h5-13H,3-4H2,1-2H3,(H2,26,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM213128
PNG
(US9278960, 8-35 | US9636337, 8-35)
Show SMILES COc1ccc(cc1)-c1cc(nc2cc(CCc3cncnc3N)ccc12)C(N)=O
Show InChI InChI=1S/C23H21N5O2/c1-30-17-7-5-15(6-8-17)19-11-21(23(25)29)28-20-10-14(3-9-18(19)20)2-4-16-12-26-13-27-22(16)24/h3,5-13H,2,4H2,1H3,(H2,25,29)(H2,24,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM213137
PNG
(US9278960, 8-44 | US9278960, 8-45 | US9636337, 8-4...)
Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(ccc12)C(C)Cc1cccnc1)C(N)=O
Show InChI InChI=1S/C25H22FN3O2/c1-15(10-16-4-3-9-28-14-16)17-5-7-20-21(13-24(25(27)30)29-23(20)11-17)19-8-6-18(31-2)12-22(19)26/h3-9,11-15H,10H2,1-2H3,(H2,27,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM213141
PNG
(US9278960, 8-48 | US9278960, 8-49 | US9636337, 8-4...)
Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(ccc12)C(C)Cc1ccc(CF)nc1)C(N)=O
Show InChI InChI=1S/C26H23F2N3O2/c1-15(9-16-3-5-18(13-27)30-14-16)17-4-7-21-22(12-25(26(29)32)31-24(21)10-17)20-8-6-19(33-2)11-23(20)28/h3-8,10-12,14-15H,9,13H2,1-2H3,(H2,29,32)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 9n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM213146
PNG
(US9278960, 8-53 | US9636337, 8-53)
Show SMILES COc1cc(C)c(c(C)c1)-c1cc(nc2cc(CCc3cnc(C)nc3)ccc12)C(N)=O
Show InChI InChI=1S/C26H26N4O2/c1-15-9-20(32-4)10-16(2)25(15)22-12-24(26(27)31)30-23-11-18(7-8-21(22)23)5-6-19-13-28-17(3)29-14-19/h7-14H,5-6H2,1-4H3,(H2,27,31)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 52n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM212841
PNG
(US9278960, 1-12 | US9663506, Example 1-12)
Show SMILES Cn1cc(cn1)-c1cc(nc2ccccc12)C(N)=O
Show InChI InChI=1S/C14H12N4O/c1-18-8-9(7-16-18)11-6-13(14(15)19)17-12-5-3-2-4-10(11)12/h2-8H,1H3,(H2,15,19)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 678n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM212860
PNG
(US9278960, 2-7 | US9663506, Example 2-7)
Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(CN3C(=O)CCC3=O)cc2n1
Show InChI InChI=1S/C21H16FN3O3/c22-14-4-2-13(3-5-14)16-10-18(21(23)28)24-17-9-12(1-6-15(16)17)11-25-19(26)7-8-20(25)27/h1-6,9-10H,7-8,11H2,(H2,23,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 9n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM212881
PNG
(US9278960, 2-28 | US9663506, Example 2-28)
Show SMILES CC1CCC(CC1)c1cc(nc2cc(CN3C(=O)CCC3=O)ccc12)C(N)=O
Show InChI InChI=1S/C22H25N3O3/c1-13-2-5-15(6-3-13)17-11-19(22(23)28)24-18-10-14(4-7-16(17)18)12-25-20(26)8-9-21(25)27/h4,7,10-11,13,15H,2-3,5-6,8-9,12H2,1H3,(H2,23,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 17n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM212887
PNG
(US9278960, 2-34 | US9663506, Example 2-34)
Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(CN3CCCS3(=O)=O)cc2n1
Show InChI InChI=1S/C20H18FN3O3S/c21-15-5-3-14(4-6-15)17-11-19(20(22)25)23-18-10-13(2-7-16(17)18)12-24-8-1-9-28(24,26)27/h2-7,10-11H,1,8-9,12H2,(H2,22,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 105n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM212892
PNG
(US9278960, 2-39 | US9663506, Example 2-39)
Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(CN3C(=O)CCC3=O)ccc12)C(N)=O
Show InChI InChI=1S/C22H18FN3O4/c1-30-13-3-5-14(17(23)9-13)16-10-19(22(24)29)25-18-8-12(2-4-15(16)18)11-26-20(27)6-7-21(26)28/h2-5,8-10H,6-7,11H2,1H3,(H2,24,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 8n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM212898
PNG
(US9278960, 3-17 | US9663506, Example 3-17)
Show SMILES CC[C@@](O)(c1cn(Cc2ccc3c(cc(nc3c2)C(N)=O)-c2ccc(F)nc2)nn1)C(F)(F)F
Show InChI InChI=1S/C22H18F4N6O2/c1-2-21(34,22(24,25)26)18-11-32(31-30-18)10-12-3-5-14-15(13-4-6-19(23)28-9-13)8-17(20(27)33)29-16(14)7-12/h3-9,11,34H,2,10H2,1H3,(H2,27,33)/t21-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 74n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM212902
PNG
(US9278960, 3-21 | US9663506, Example 3-21)
Show SMILES CCOC(=O)c1cnn(Cc2ccc3c(cc(nc3c2)C(N)=O)-c2ccc(F)cc2)c1
Show InChI InChI=1S/C23H19FN4O3/c1-2-31-23(30)16-11-26-28(13-16)12-14-3-8-18-19(15-4-6-17(24)7-5-15)10-21(22(25)29)27-20(18)9-14/h3-11,13H,2,12H2,1H3,(H2,25,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 40n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM212920
PNG
(US9278960, 3-39 | US9663506, Example 3-39)
Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(Cn3c(nc4ccccc34)C3CC3)cc2n1
Show InChI InChI=1S/C27H21FN4O/c28-19-10-8-17(9-11-19)21-14-24(26(29)33)30-23-13-16(5-12-20(21)23)15-32-25-4-2-1-3-22(25)31-27(32)18-6-7-18/h1-5,8-14,18H,6-7,15H2,(H2,29,33)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 73n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM212924
PNG
(US9278960, 3-43 | US9663506, Example 3-43)
Show SMILES CC(C)c1nc2ccccc2n1Cc1ccc2c(cc(nc2c1)C(N)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C27H23FN4O/c1-16(2)27-31-22-5-3-4-6-25(22)32(27)15-17-7-12-20-21(18-8-10-19(28)11-9-18)14-24(26(29)33)30-23(20)13-17/h3-14,16H,15H2,1-2H3,(H2,29,33)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 66n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM212929
PNG
(US9278960, 3-48 | US9278960, 3-50 | US9663506, Exa...)
Show SMILES CCC(O)(c1cn(Cc2ccc3c(cc(nc3c2)C(N)=O)-c2ccc(OC)cc2F)cn1)C(F)(F)F
Show InChI InChI=1S/C25H22F4N4O3/c1-3-24(35,25(27,28)29)22-12-33(13-31-22)11-14-4-6-17-18(10-21(23(30)34)32-20(17)8-14)16-7-5-15(36-2)9-19(16)26/h4-10,12-13,35H,3,11H2,1-2H3,(H2,30,34)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 16n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...


US Patent US9636337 (2017)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 315 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%