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Patent code US9637472

Compile Data Set for Download or QSAR

Found 391 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326080
PNG
(US9637472, Compound C-13)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)-c2ccc(CC3CCC[C@@H]3C(N)=O)cc2)c(=O)[nH]1
Show InChI InChI=1S/C34H39N5O3/c1-20-14-21(2)38-34(42)29(20)18-36-33(41)28-16-25(17-31-30(28)19-37-39(31)26-7-3-4-8-26)23-12-10-22(11-13-23)15-24-6-5-9-27(24)32(35)40/h10-14,16-17,19,24,26-27H,3-9,15,18H2,1-2H3,(H2,35,40)(H,36,41)(H,38,42)/t24?,27-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326082
PNG
(US9637472, Compound C-15)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)-c2ccc(CN3CCOCC3)cn2)c(=O)[nH]1
Show InChI InChI=1S/C31H36N6O3/c1-20-13-21(2)35-31(39)26(20)17-33-30(38)25-14-23(15-29-27(25)18-34-37(29)24-5-3-4-6-24)28-8-7-22(16-32-28)19-36-9-11-40-12-10-36/h7-8,13-16,18,24H,3-6,9-12,17,19H2,1-2H3,(H,33,38)(H,35,39)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326083
PNG
(US9637472, Compound C-16)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)-c2ccc(C)c(c2)S(N)(=O)=O)c(=O)[nH]1
Show InChI InChI=1S/C28H31N5O4S/c1-16-8-9-19(13-26(16)38(29,36)37)20-11-22(24-15-31-33(25(24)12-20)21-6-4-5-7-21)27(34)30-14-23-17(2)10-18(3)32-28(23)35/h8-13,15,21H,4-7,14H2,1-3H3,(H,30,34)(H,32,35)(H2,29,36,37)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326096
PNG
(US9637472, Compound C-29)
Show SMILES CN(CCO)Cc1cccc(c1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C3CCCC3)c2c1
Show InChI InChI=1S/C31H37N5O3/c1-20-13-21(2)34-31(39)27(20)17-32-30(38)26-15-24(23-8-6-7-22(14-23)19-35(3)11-12-37)16-29-28(26)18-33-36(29)25-9-4-5-10-25/h6-8,13-16,18,25,37H,4-5,9-12,17,19H2,1-3H3,(H,32,38)(H,34,39)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326126
PNG
(US9637472, Compound D-24)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(Cl)cc3n(ncc23)C2CCN(CC2)C(=O)C(C)(C)C)c(=O)[nH]1
Show InChI InChI=1S/C26H32ClN5O3/c1-15-10-16(2)30-24(34)20(15)13-28-23(33)19-11-17(27)12-22-21(19)14-29-32(22)18-6-8-31(9-7-18)25(35)26(3,4)5/h10-12,14,18H,6-9,13H2,1-5H3,(H,28,33)(H,30,34)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326132
PNG
(US9637472, Compound D-30)
Show SMILES CN(C)CCCN1CCC(CC1)c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C3CCCC3)c2c1
Show InChI InChI=1S/C31H44N6O2/c1-21-16-22(2)34-31(39)27(21)19-32-30(38)26-17-24(23-10-14-36(15-11-23)13-7-12-35(3)4)18-29-28(26)20-33-37(29)25-8-5-6-9-25/h16-18,20,23,25H,5-15,19H2,1-4H3,(H,32,38)(H,34,39)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326151
PNG
(US9637472, Compound D-49)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)C2=CCN(CCN)CC2)c(=O)[nH]1
Show InChI InChI=1S/C28H36N6O2/c1-18-13-19(2)32-28(36)24(18)16-30-27(35)23-14-21(20-7-10-33(11-8-20)12-9-29)15-26-25(23)17-31-34(26)22-5-3-4-6-22/h7,13-15,17,22H,3-6,8-12,16,29H2,1-2H3,(H,30,35)(H,32,36)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM325819
PNG
(US9637472, Compound A-15)
Show SMILES CC(C)n1ncc2c(cc(nc12)-c1ccc(CN(C)CCCN(C)C)cc1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C31H41N7O2/c1-20(2)38-29-27(18-33-38)25(30(39)32-17-26-21(3)15-22(4)34-31(26)40)16-28(35-29)24-11-9-23(10-12-24)19-37(7)14-8-13-36(5)6/h9-12,15-16,18,20H,8,13-14,17,19H2,1-7H3,(H,32,39)(H,34,40)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM325914
PNG
(US9637472, Compound B-8)
Show SMILES CC(C)n1ncc2c(cc(nc12)C1CCN(CC1)C(=O)C1CN(C)C1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C28H37N7O3/c1-16(2)35-25-23(13-30-35)21(26(36)29-12-22-17(3)10-18(4)31-27(22)37)11-24(32-25)19-6-8-34(9-7-19)28(38)20-14-33(5)15-20/h10-11,13,16,19-20H,6-9,12,14-15H2,1-5H3,(H,29,36)(H,31,37)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM325926
PNG
(US9637472, Compound B-20)
Show SMILES CC(C)n1ncc2c(cc(nc12)C1=CCN(CC1)C(=O)C1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C29H37N7O3/c1-17(2)36-26-24(16-32-36)22(27(37)31-15-23-18(3)13-19(4)33-28(23)38)14-25(34-26)20-7-11-35(12-8-20)29(39)21-5-9-30-10-6-21/h7,13-14,16-17,21,30H,5-6,8-12,15H2,1-4H3,(H,31,37)(H,33,38)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM325935
PNG
(US9637472, Compound B-29)
Show SMILES CC(C)n1ncc2c(cc(nc12)C1CCN(CC1)C1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C28H39N7O2/c1-17(2)35-26-24(16-31-35)22(27(36)30-15-23-18(3)13-19(4)32-28(23)37)14-25(33-26)20-7-11-34(12-8-20)21-5-9-29-10-6-21/h13-14,16-17,20-21,29H,5-12,15H2,1-4H3,(H,30,36)(H,32,37)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50075051
PNG
(CHEMBL3360855 | EPZ005687 | US9175331, 7 | US96374...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)-c2ccc(CN3CCOCC3)cc2)c(=O)[nH]1
Show InChI InChI=1S/C32H37N5O3/c1-21-15-22(2)35-32(39)28(21)18-33-31(38)27-16-25(17-30-29(27)19-34-37(30)26-5-3-4-6-26)24-9-7-23(8-10-24)20-36-11-13-40-14-12-36/h7-10,15-17,19,26H,3-6,11-14,18,20H2,1-2H3,(H,33,38)(H,35,39)
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US Patent
n/an/a<300n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326072
PNG
(US9637472, Compound C-5)
Show SMILES CC(C)n1ncc2c(cc(cc12)-c1ccc(CN2CCOCC2)cc1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C30H35N5O3/c1-19(2)35-28-15-24(23-7-5-22(6-8-23)18-34-9-11-38-12-10-34)14-25(27(28)17-32-35)29(36)31-16-26-20(3)13-21(4)33-30(26)37/h5-8,13-15,17,19H,9-12,16,18H2,1-4H3,(H,31,36)(H,33,37)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326077
PNG
(US9637472, Compound C-10)
Show SMILES CNCCCOc1cccc(c1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C3CCCC3)c2c1
Show InChI InChI=1S/C31H37N5O3/c1-20-14-21(2)35-31(38)27(20)18-33-30(37)26-16-23(22-8-6-11-25(15-22)39-13-7-12-32-3)17-29-28(26)19-34-36(29)24-9-4-5-10-24/h6,8,11,14-17,19,24,32H,4-5,7,9-10,12-13,18H2,1-3H3,(H,33,37)(H,35,38)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326090
PNG
(US9637472, Compound C-23)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)-c2cccc(COCCN)c2)c(=O)[nH]1
Show InChI InChI=1S/C30H35N5O3/c1-19-12-20(2)34-30(37)26(19)16-32-29(36)25-14-23(22-7-5-6-21(13-22)18-38-11-10-31)15-28-27(25)17-33-35(28)24-8-3-4-9-24/h5-7,12-15,17,24H,3-4,8-11,16,18,31H2,1-2H3,(H,32,36)(H,34,37)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326100
PNG
(US9637472, Compound C-33)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)-c2cnn(CCN3CCOCC3)c2)c(=O)[nH]1
Show InChI InChI=1S/C30H37N7O3/c1-20-13-21(2)34-30(39)26(20)17-31-29(38)25-14-22(15-28-27(25)18-33-37(28)24-5-3-4-6-24)23-16-32-36(19-23)8-7-35-9-11-40-12-10-35/h13-16,18-19,24H,3-12,17H2,1-2H3,(H,31,38)(H,34,39)
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US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326106
PNG
(US9637472, Compound D-4)
Show SMILES CC(=O)N1CCC(=CC1)c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C3CCCC3)c2c1
Show InChI InChI=1S/C28H33N5O3/c1-17-12-18(2)31-28(36)24(17)15-29-27(35)23-13-21(20-8-10-32(11-9-20)19(3)34)14-26-25(23)16-30-33(26)22-6-4-5-7-22/h8,12-14,16,22H,4-7,9-11,15H2,1-3H3,(H,29,35)(H,31,36)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326115
PNG
(US9637472, Compound D-13)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(Br)cc3n(ncc23)C2CCN(CC2)C(=O)C(C)(C)C)c(=O)[nH]1
Show InChI InChI=1S/C26H32BrN5O3/c1-15-10-16(2)30-24(34)20(15)13-28-23(33)19-11-17(27)12-22-21(19)14-29-32(22)18-6-8-31(9-7-18)25(35)26(3,4)5/h10-12,14,18H,6-9,13H2,1-5H3,(H,28,33)(H,30,34)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326135
PNG
(US9637472, Compound D-33)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(Br)cc3n(ncc23)C2CCN(C2)C(=O)C(C)(C)C)c(=O)[nH]1
Show InChI InChI=1S/C25H30BrN5O3/c1-14-8-15(2)29-23(33)19(14)11-27-22(32)18-9-16(26)10-21-20(18)12-28-31(21)17-6-7-30(13-17)24(34)25(3,4)5/h8-10,12,17H,6-7,11,13H2,1-5H3,(H,27,32)(H,29,33)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM325817
PNG
(US9637472, Compound A-13)
Show SMILES CC(C)n1ncc2c(cc(nc12)-c1cccc(c1)C(=O)NCCCN(C)C)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C30H37N7O3/c1-18(2)37-27-25(17-33-37)23(29(39)32-16-24-19(3)13-20(4)34-30(24)40)15-26(35-27)21-9-7-10-22(14-21)28(38)31-11-8-12-36(5)6/h7,9-10,13-15,17-18H,8,11-12,16H2,1-6H3,(H,31,38)(H,32,39)(H,34,40)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM325910
PNG
(US9637472, Compound B-4 | US9637472, Compound B-5)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(nc3n(ncc23)C2CCCC2)C2=CC(C)(C)NC(C)(C)C2)c(=O)[nH]1
Show InChI InChI=1S/C29H38N6O2/c1-17-11-18(2)32-27(37)22(17)15-30-26(36)21-12-24(19-13-28(3,4)34-29(5,6)14-19)33-25-23(21)16-31-35(25)20-9-7-8-10-20/h11-13,16,20,34H,7-10,14-15H2,1-6H3,(H,30,36)(H,32,37)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326071
PNG
(US9637472, Compound C-4)
Show SMILES CN(C)CCCOCc1ccc(cc1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C3CCCC3)c2c1
Show InChI InChI=1S/C33H41N5O3/c1-22-16-23(2)36-33(40)29(22)19-34-32(39)28-17-26(18-31-30(28)20-35-38(31)27-8-5-6-9-27)25-12-10-24(11-13-25)21-41-15-7-14-37(3)4/h10-13,16-18,20,27H,5-9,14-15,19,21H2,1-4H3,(H,34,39)(H,36,40)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326079
PNG
(US9637472, Compound C-12)
Show SMILES CNCCCOc1ccc(cc1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C3CCCC3)c2c1
Show InChI InChI=1S/C31H37N5O3/c1-20-15-21(2)35-31(38)27(20)18-33-30(37)26-16-23(22-9-11-25(12-10-22)39-14-6-13-32-3)17-29-28(26)19-34-36(29)24-7-4-5-8-24/h9-12,15-17,19,24,32H,4-8,13-14,18H2,1-3H3,(H,33,37)(H,35,38)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326084
PNG
(US9637472, Compound C-17)
Show SMILES CN(C)CCCN(C)Cc1ccc(cc1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C3CCCC3)c2c1
Show InChI InChI=1S/C34H44N6O2/c1-23-17-24(2)37-34(42)30(23)20-35-33(41)29-18-27(19-32-31(29)21-36-40(32)28-9-6-7-10-28)26-13-11-25(12-14-26)22-39(5)16-8-15-38(3)4/h11-14,17-19,21,28H,6-10,15-16,20,22H2,1-5H3,(H,35,41)(H,37,42)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326092
PNG
(US9637472, Compound C-25)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)-c2ccc(CN3CCNC(=O)C3)cc2)c(=O)[nH]1
Show InChI InChI=1S/C32H36N6O3/c1-20-13-21(2)36-32(41)27(20)16-34-31(40)26-14-24(15-29-28(26)17-35-38(29)25-5-3-4-6-25)23-9-7-22(8-10-23)18-37-12-11-33-30(39)19-37/h7-10,13-15,17,25H,3-6,11-12,16,18-19H2,1-2H3,(H,33,39)(H,34,40)(H,36,41)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326098
PNG
(US9637472, Compound C-31)
Show SMILES CN(C)Cc1ccc(cc1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C3CCN(CC3)C(=O)C(C)(C)C)c2c1
Show InChI InChI=1S/C35H44N6O3/c1-22-16-23(2)38-33(43)29(22)19-36-32(42)28-17-26(25-10-8-24(9-11-25)21-39(6)7)18-31-30(28)20-37-41(31)27-12-14-40(15-13-27)34(44)35(3,4)5/h8-11,16-18,20,27H,12-15,19,21H2,1-7H3,(H,36,42)(H,38,43)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326102
PNG
(US9637472, Compound C-35)
Show SMILES CN(C)CCCOc1ccc(cc1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C3CCCC3)c2c1
Show InChI InChI=1S/C32H39N5O3/c1-21-16-22(2)35-32(39)28(21)19-33-31(38)27-17-24(18-30-29(27)20-34-37(30)25-8-5-6-9-25)23-10-12-26(13-11-23)40-15-7-14-36(3)4/h10-13,16-18,20,25H,5-9,14-15,19H2,1-4H3,(H,33,38)(H,35,39)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326114
PNG
(US9637472, Compound D-12)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(Br)cc3n(ncc23)C2CCN(CC2)C(=O)OC(C)(C)C)c(=O)[nH]1
Show InChI InChI=1S/C26H32BrN5O4/c1-15-10-16(2)30-24(34)20(15)13-28-23(33)19-11-17(27)12-22-21(19)14-29-32(22)18-6-8-31(9-7-18)25(35)36-26(3,4)5/h10-12,14,18H,6-9,13H2,1-5H3,(H,28,33)(H,30,34)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326127
PNG
(US9637472, Compound D-25)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCN(CC2)C(=O)C(C)(C)C)C2=CC(C)(C)NC(C)(C)C2)c(=O)[nH]1
Show InChI InChI=1S/C35H48N6O3/c1-21-14-22(2)38-31(43)27(21)19-36-30(42)26-15-23(24-17-34(6,7)39-35(8,9)18-24)16-29-28(26)20-37-41(29)25-10-12-40(13-11-25)32(44)33(3,4)5/h14-17,20,25,39H,10-13,18-19H2,1-9H3,(H,36,42)(H,38,43)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326103
PNG
(US9637472, Compound D-1 | US9637472, Compound D-40)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(Br)cc3n(ncc23)C2CCCC2)c(=O)[nH]1
Show InChI InChI=1S/C21H23BrN4O2/c1-12-7-13(2)25-21(28)17(12)10-23-20(27)16-8-14(22)9-19-18(16)11-24-26(19)15-5-3-4-6-15/h7-9,11,15H,3-6,10H2,1-2H3,(H,23,27)(H,25,28)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326196
PNG
(US9637472, Compound D-95)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)C2=CCN(CCO)CC2)c(=O)[nH]1
Show InChI InChI=1S/C28H35N5O3/c1-18-13-19(2)31-28(36)24(18)16-29-27(35)23-14-21(20-7-9-32(10-8-20)11-12-34)15-26-25(23)17-30-33(26)22-5-3-4-6-22/h7,13-15,17,22,34H,3-6,8-12,16H2,1-2H3,(H,29,35)(H,31,36)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM325821
PNG
(US9637472, Compound A-17)
Show SMILES CC(C)n1nc(Br)c2c(cc(nc12)-c1ccc(CN2CCOCC2)cc1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C29H33BrN6O3/c1-17(2)36-27-25(26(30)34-36)22(28(37)31-15-23-18(3)13-19(4)32-29(23)38)14-24(33-27)21-7-5-20(6-8-21)16-35-9-11-39-12-10-35/h5-8,13-14,17H,9-12,15-16H2,1-4H3,(H,31,37)(H,32,38)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326078
PNG
(US9637472, Compound C-11)
Show SMILES CN(C)CCCOc1cccc(c1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C3CCCC3)c2c1
Show InChI InChI=1S/C32H39N5O3/c1-21-15-22(2)35-32(39)28(21)19-33-31(38)27-17-24(18-30-29(27)20-34-37(30)25-10-5-6-11-25)23-9-7-12-26(16-23)40-14-8-13-36(3)4/h7,9,12,15-18,20,25H,5-6,8,10-11,13-14,19H2,1-4H3,(H,33,38)(H,35,39)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326104
PNG
(US9637472, Compound D-2)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)C2=CC(C)(C)NC(C)(C)C2)c(=O)[nH]1
Show InChI InChI=1S/C30H39N5O2/c1-18-11-19(2)33-28(37)24(18)16-31-27(36)23-12-20(21-14-29(3,4)34-30(5,6)15-21)13-26-25(23)17-32-35(26)22-9-7-8-10-22/h11-14,17,22,34H,7-10,15-16H2,1-6H3,(H,31,36)(H,33,37)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326116
PNG
(US9637472, Compound D-14)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(Br)cc3n(ncc23)C2CCN(CC2)C(=O)C2CNC2)c(=O)[nH]1
Show InChI InChI=1S/C25H29BrN6O3/c1-14-7-15(2)30-24(34)20(14)12-28-23(33)19-8-17(26)9-22-21(19)13-29-32(22)18-3-5-31(6-4-18)25(35)16-10-27-11-16/h7-9,13,16,18,27H,3-6,10-12H2,1-2H3,(H,28,33)(H,30,34)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326118
PNG
(US9637472, Compound D-16)
Show SMILES CN1CCC(CC1)N1CCC(CC1)n1ncc2c(cc(Br)cc12)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C27H35BrN6O2/c1-17-12-18(2)31-27(36)23(17)15-29-26(35)22-13-19(28)14-25-24(22)16-30-34(25)21-6-10-33(11-7-21)20-4-8-32(3)9-5-20/h12-14,16,20-21H,4-11,15H2,1-3H3,(H,29,35)(H,31,36)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326125
PNG
(US9637472, Compound D-23)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCN(CC2)C(=O)C(C)(C)C)C(F)(F)F)c(=O)[nH]1
Show InChI InChI=1S/C27H32F3N5O3/c1-15-10-16(2)33-24(37)20(15)13-31-23(36)19-11-17(27(28,29)30)12-22-21(19)14-32-35(22)18-6-8-34(9-7-18)25(38)26(3,4)5/h10-12,14,18H,6-9,13H2,1-5H3,(H,31,36)(H,33,37)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326149
PNG
(US9637472, Compound D-47)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)C2=CCN(CC2)C(=O)CN)c(=O)[nH]1
Show InChI InChI=1S/C28H34N6O3/c1-17-11-18(2)32-28(37)23(17)15-30-27(36)22-12-20(19-7-9-33(10-8-19)26(35)14-29)13-25-24(22)16-31-34(25)21-5-3-4-6-21/h7,11-13,16,21H,3-6,8-10,14-15,29H2,1-2H3,(H,30,36)(H,32,37)
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US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326150
PNG
(US9637472, Compound D-48)
Show SMILES CNCCN1CCC(=CC1)c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C3CCCC3)c2c1
Show InChI InChI=1S/C29H38N6O2/c1-19-14-20(2)33-29(37)25(19)17-31-28(36)24-15-22(21-8-11-34(12-9-21)13-10-30-3)16-27-26(24)18-32-35(27)23-6-4-5-7-23/h8,14-16,18,23,30H,4-7,9-13,17H2,1-3H3,(H,31,36)(H,33,37)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326154
PNG
(US9637472, Compound D-52)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(Br)cc3n(ncc23)C2CCN(CC2)C(=O)C2CCNCC2)c(=O)[nH]1
Show InChI InChI=1S/C27H33BrN6O3/c1-16-11-17(2)32-26(36)22(16)14-30-25(35)21-12-19(28)13-24-23(21)15-31-34(24)20-5-9-33(10-6-20)27(37)18-3-7-29-8-4-18/h11-13,15,18,20,29H,3-10,14H2,1-2H3,(H,30,35)(H,32,36)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326201
PNG
(US9637472, Compound E-2)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ccc23)C2CCCC2)-c2ccc(CN3CCOCC3)cc2)c(=O)[nH]1
Show InChI InChI=1S/C33H38N4O3/c1-22-17-23(2)35-33(39)30(22)20-34-32(38)29-18-26(19-31-28(29)11-12-37(31)27-5-3-4-6-27)25-9-7-24(8-10-25)21-36-13-15-40-16-14-36/h7-12,17-19,27H,3-6,13-16,20-21H2,1-2H3,(H,34,38)(H,35,39)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50149602
PNG
(CHEMBL3770239 | US9637472, Compound A-10)
Show SMILES CC(C)n1ncc2c(cc(nc12)-c1ccc(nc1)N1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C27H32N8O2/c1-16(2)35-25-22(15-31-35)20(26(36)30-14-21-17(3)11-18(4)32-27(21)37)12-23(33-25)19-5-6-24(29-13-19)34-9-7-28-8-10-34/h5-6,11-13,15-16,28H,7-10,14H2,1-4H3,(H,30,36)(H,32,37)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM325938
PNG
(US9637472, Compound B-32)
Show SMILES CC(C)n1ncc2c(cc(nc12)C1=CCN(CC1)C(=O)C1CCCN(C)C1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C30H39N7O3/c1-18(2)37-27-25(16-32-37)23(28(38)31-15-24-19(3)13-20(4)33-29(24)39)14-26(34-27)21-8-11-36(12-9-21)30(40)22-7-6-10-35(5)17-22/h8,13-14,16,18,22H,6-7,9-12,15,17H2,1-5H3,(H,31,38)(H,33,39)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326076
PNG
(US9637472, Compound C-9)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)-c2cccc(CNCCO)c2)c(=O)[nH]1
Show InChI InChI=1S/C30H35N5O3/c1-19-12-20(2)34-30(38)26(19)17-32-29(37)25-14-23(22-7-5-6-21(13-22)16-31-10-11-36)15-28-27(25)18-33-35(28)24-8-3-4-9-24/h5-7,12-15,18,24,31,36H,3-4,8-11,16-17H2,1-2H3,(H,32,37)(H,34,38)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326081
PNG
(US9637472, Compound C-14)
Show SMILES CCOc1ccc(cc1-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C3CCCC3)c2c1)S(=O)(=O)N1CCN(CC)CC1
Show InChI InChI=1S/C35H44N6O5S/c1-5-39-13-15-40(16-14-39)47(44,45)27-11-12-33(46-6-2)28(20-27)25-18-29(31-22-37-41(32(31)19-25)26-9-7-8-10-26)34(42)36-21-30-23(3)17-24(4)38-35(30)43/h11-12,17-20,22,26H,5-10,13-16,21H2,1-4H3,(H,36,42)(H,38,43)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326087
PNG
(US9637472, Compound C-20)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)-c2ccc(COCCN3CCOCC3)cc2)c(=O)[nH]1
Show InChI InChI=1S/C34H41N5O4/c1-23-17-24(2)37-34(41)30(23)20-35-33(40)29-18-27(19-32-31(29)21-36-39(32)28-5-3-4-6-28)26-9-7-25(8-10-26)22-43-16-13-38-11-14-42-15-12-38/h7-10,17-19,21,28H,3-6,11-16,20,22H2,1-2H3,(H,35,40)(H,37,41)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326105
PNG
(US9637472, Compound D-3)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)C2CC(C)(C)NC(C)(C)C2)c(=O)[nH]1
Show InChI InChI=1S/C30H41N5O2/c1-18-11-19(2)33-28(37)24(18)16-31-27(36)23-12-20(21-14-29(3,4)34-30(5,6)15-21)13-26-25(23)17-32-35(26)22-9-7-8-10-22/h11-13,17,21-22,34H,7-10,14-16H2,1-6H3,(H,31,36)(H,33,37)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326139
PNG
(US9637472, Compound D-37)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)C2=CCN(CC2)C(=O)C2CNC2)c(=O)[nH]1
Show InChI InChI=1S/C30H36N6O3/c1-18-11-19(2)34-29(38)25(18)16-32-28(37)24-12-21(13-27-26(24)17-33-36(27)23-5-3-4-6-23)20-7-9-35(10-8-20)30(39)22-14-31-15-22/h7,11-13,17,22-23,31H,3-6,8-10,14-16H2,1-2H3,(H,32,37)(H,34,38)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326140
PNG
(US9637472, Compound D-38)
Show SMILES CN(C)CC(=O)N1CCC(=CC1)c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C3CCCC3)c2c1
Show InChI InChI=1S/C30H38N6O3/c1-19-13-20(2)33-30(39)25(19)16-31-29(38)24-14-22(21-9-11-35(12-10-21)28(37)18-34(3)4)15-27-26(24)17-32-36(27)23-7-5-6-8-23/h9,13-15,17,23H,5-8,10-12,16,18H2,1-4H3,(H,31,38)(H,33,39)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326147
PNG
(US9637472, Compound D-45)
Show SMILES CNCC(=O)N1CCC(=CC1)c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C3CCCC3)c2c1
Show InChI InChI=1S/C29H36N6O3/c1-18-12-19(2)33-29(38)24(18)15-31-28(37)23-13-21(20-8-10-34(11-9-20)27(36)17-30-3)14-26-25(23)16-32-35(26)22-6-4-5-7-22/h8,12-14,16,22,30H,4-7,9-11,15,17H2,1-3H3,(H,31,37)(H,33,38)
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Epizyme, Inc.

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%