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Patent code US9637484

Compile Data Set for Download or QSAR
Found 20 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Solute carrier family 22 member 12 (URAT1)


(Homo sapiens (Human))
BDBM50134635
PNG
(CHEMBL3746329 | US9637484, 3)
Show SMILES OC(=O)C1(CCC1)Sc1ccnc2ccc(Br)cc12
Show InChI InChI=1S/C14H12BrNO2S/c15-9-2-3-11-10(8-9)12(4-7-16-11)19-14(13(17)18)5-1-6-14/h2-4,7-8H,1,5-6H2,(H,17,18)
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US Patent
n/an/a 19n/an/an/an/an/an/a



SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; JIANGSU HENGRUI MEDICINE CO., LTD.

US Patent


Assay Description
In vitro URAT1 assay can be used to identify compounds having potential activity for decreasing serum uric acid. In a suitable test, the vectors that...


US Patent US9637484 (2017)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12 (URAT1)


(Homo sapiens (Human))
BDBM50134637
PNG
(CHEMBL3746480 | US9637484, 2)
Show SMILES OC(=O)C1(CCC1)Sc1ccnc2ccc(cc12)C(F)(F)F
Show InChI InChI=1S/C15H12F3NO2S/c16-15(17,18)9-2-3-11-10(8-9)12(4-7-19-11)22-14(13(20)21)5-1-6-14/h2-4,7-8H,1,5-6H2,(H,20,21)
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n/an/a 61n/an/an/an/an/an/a



SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; JIANGSU HENGRUI MEDICINE CO., LTD.

US Patent


Assay Description
In vitro URAT1 assay can be used to identify compounds having potential activity for decreasing serum uric acid. In a suitable test, the vectors that...


US Patent US9637484 (2017)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12 (URAT1)


(Homo sapiens (Human))
BDBM50134675
PNG
(CHEMBL3747573 | US9637484, 22)
Show SMILES OC(=O)C1(CCC1)Sc1ccnc2ccc(cc12)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C21H16F3NO2S/c22-21(23,24)16-5-2-1-4-14(16)13-6-7-17-15(12-13)18(8-11-25-17)28-20(19(26)27)9-3-10-20/h1-2,4-8,11-12H,3,9-10H2,(H,26,27)
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n/an/a 115n/an/an/an/an/an/a



SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; JIANGSU HENGRUI MEDICINE CO., LTD.

US Patent


Assay Description
In vitro URAT1 assay can be used to identify compounds having potential activity for decreasing serum uric acid. In a suitable test, the vectors that...


US Patent US9637484 (2017)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12 (URAT1)


(Homo sapiens (Human))
BDBM50134634
PNG
(CHEMBL3745847 | US9637484, 31)
Show SMILES OC(=O)C1(CCC1)Sc1ccnc2cc(Br)ccc12
Show InChI InChI=1S/C14H12BrNO2S/c15-9-2-3-10-11(8-9)16-7-4-12(10)19-14(13(17)18)5-1-6-14/h2-4,7-8H,1,5-6H2,(H,17,18)
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n/an/a 129n/an/an/an/an/an/a



SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; JIANGSU HENGRUI MEDICINE CO., LTD.

US Patent


Assay Description
In vitro URAT1 assay can be used to identify compounds having potential activity for decreasing serum uric acid. In a suitable test, the vectors that...


US Patent US9637484 (2017)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12 (URAT1)


(Homo sapiens (Human))
BDBM50134670
PNG
(CHEMBL3745776 | US9637484, 7)
Show SMILES OC(=O)C1(CCC1)Sc1ccnc2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C20H16FNO2S/c21-15-5-2-13(3-6-15)14-4-7-17-16(12-14)18(8-11-22-17)25-20(19(23)24)9-1-10-20/h2-8,11-12H,1,9-10H2,(H,23,24)
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n/an/a 159n/an/an/an/an/an/a



SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; JIANGSU HENGRUI MEDICINE CO., LTD.

US Patent


Assay Description
In vitro URAT1 assay can be used to identify compounds having potential activity for decreasing serum uric acid. In a suitable test, the vectors that...


US Patent US9637484 (2017)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12 (URAT1)


(Homo sapiens (Human))
BDBM326044
PNG
(1-((6-(2-methoxy-2-oxoethoxy)quinolin-4-yl)thio)cy...)
Show SMILES COC(=O)COc1ccc2nccc(SC3(CCC3)C(O)=O)c2c1
Show InChI InChI=1S/C17H17NO5S/c1-22-15(19)10-23-11-3-4-13-12(9-11)14(5-8-18-13)24-17(16(20)21)6-2-7-17/h3-5,8-9H,2,6-7,10H2,1H3,(H,20,21)
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n/an/a 164n/an/an/an/an/an/a



SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; JIANGSU HENGRUI MEDICINE CO., LTD.

US Patent


Assay Description
In vitro URAT1 assay can be used to identify compounds having potential activity for decreasing serum uric acid. In a suitable test, the vectors that...


US Patent US9637484 (2017)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12 (URAT1)


(Homo sapiens (Human))
BDBM50134644
PNG
(CHEMBL3746658 | US9637484, 9)
Show SMILES COCc1ccc2nccc(SC3(CCC3)C(O)=O)c2c1
Show InChI InChI=1S/C16H17NO3S/c1-20-10-11-3-4-13-12(9-11)14(5-8-17-13)21-16(15(18)19)6-2-7-16/h3-5,8-9H,2,6-7,10H2,1H3,(H,18,19)
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n/an/a 197n/an/an/an/an/an/a



SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; JIANGSU HENGRUI MEDICINE CO., LTD.

US Patent


Assay Description
In vitro URAT1 assay can be used to identify compounds having potential activity for decreasing serum uric acid. In a suitable test, the vectors that...


US Patent US9637484 (2017)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12 (URAT1)


(Homo sapiens (Human))
BDBM50134645
PNG
(CHEMBL3746426 | US9637484, 5)
Show SMILES COCCOc1ccc2nccc(SC3(CCC3)C(O)=O)c2c1
Show InChI InChI=1S/C17H19NO4S/c1-21-9-10-22-12-3-4-14-13(11-12)15(5-8-18-14)23-17(16(19)20)6-2-7-17/h3-5,8,11H,2,6-7,9-10H2,1H3,(H,19,20)
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n/an/a 207n/an/an/an/an/an/a



SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; JIANGSU HENGRUI MEDICINE CO., LTD.

US Patent


Assay Description
In vitro URAT1 assay can be used to identify compounds having potential activity for decreasing serum uric acid. In a suitable test, the vectors that...


US Patent US9637484 (2017)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12 (URAT1)


(Homo sapiens (Human))
BDBM50134665
PNG
(CHEMBL3747343 | US9637484, 1)
Show SMILES OC(=O)C1(CCC1)Sc1ccnc2ccccc12
Show InChI InChI=1S/C14H13NO2S/c16-13(17)14(7-3-8-14)18-12-6-9-15-11-5-2-1-4-10(11)12/h1-2,4-6,9H,3,7-8H2,(H,16,17)
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n/an/a 251n/an/an/an/an/an/a



SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; JIANGSU HENGRUI MEDICINE CO., LTD.

US Patent


Assay Description
In vitro URAT1 assay can be used to identify compounds having potential activity for decreasing serum uric acid. In a suitable test, the vectors that...


US Patent US9637484 (2017)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12 (URAT1)


(Homo sapiens (Human))
BDBM50134633
PNG
(CHEMBL3747024 | US9637484, 33)
Show SMILES OC(=O)C1(CC1)Sc1ccnc2ccc(Br)cc12
Show InChI InChI=1S/C13H10BrNO2S/c14-8-1-2-10-9(7-8)11(3-6-15-10)18-13(4-5-13)12(16)17/h1-3,6-7H,4-5H2,(H,16,17)
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n/an/a 324n/an/an/an/an/an/a



SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; JIANGSU HENGRUI MEDICINE CO., LTD.

US Patent


Assay Description
In vitro URAT1 assay can be used to identify compounds having potential activity for decreasing serum uric acid. In a suitable test, the vectors that...


US Patent US9637484 (2017)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12 (URAT1)


(Homo sapiens (Human))
BDBM50134671
PNG
(CHEMBL3745813 | US9637484, 6)
Show SMILES OC(=O)C1(CCC1)Sc1ccnc2ccc(cc12)-c1cccc(F)c1
Show InChI InChI=1S/C20H16FNO2S/c21-15-4-1-3-13(11-15)14-5-6-17-16(12-14)18(7-10-22-17)25-20(19(23)24)8-2-9-20/h1,3-7,10-12H,2,8-9H2,(H,23,24)
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US Patent
n/an/a 332n/an/an/an/an/an/a



SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; JIANGSU HENGRUI MEDICINE CO., LTD.

US Patent


Assay Description
In vitro URAT1 assay can be used to identify compounds having potential activity for decreasing serum uric acid. In a suitable test, the vectors that...


US Patent US9637484 (2017)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12 (URAT1)


(Homo sapiens (Human))
BDBM50134638
PNG
(CHEMBL3746315 | US9637484, 30)
Show SMILES Cc1ccc2nccc(SC3(CCC3)C(O)=O)c2c1
Show InChI InChI=1S/C15H15NO2S/c1-10-3-4-12-11(9-10)13(5-8-16-12)19-15(14(17)18)6-2-7-15/h3-5,8-9H,2,6-7H2,1H3,(H,17,18)
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n/an/a 343n/an/an/an/an/an/a



SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; JIANGSU HENGRUI MEDICINE CO., LTD.

US Patent


Assay Description
In vitro URAT1 assay can be used to identify compounds having potential activity for decreasing serum uric acid. In a suitable test, the vectors that...


US Patent US9637484 (2017)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12 (URAT1)


(Homo sapiens (Human))
BDBM50134659
PNG
(CHEMBL3746049 | US9637484, 4)
Show SMILES COc1ccc2nccc(SC3(CCC3)C(O)=O)c2c1
Show InChI InChI=1S/C15H15NO3S/c1-19-10-3-4-12-11(9-10)13(5-8-16-12)20-15(14(17)18)6-2-7-15/h3-5,8-9H,2,6-7H2,1H3,(H,17,18)
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n/an/a 343n/an/an/an/an/an/a



SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; JIANGSU HENGRUI MEDICINE CO., LTD.

US Patent


Assay Description
In vitro URAT1 assay can be used to identify compounds having potential activity for decreasing serum uric acid. In a suitable test, the vectors that...


US Patent US9637484 (2017)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12 (URAT1)


(Homo sapiens (Human))
BDBM50134677
PNG
(CHEMBL3747526 | US9637484, 32)
Show SMILES OC(=O)C1(CCCC1)Sc1ccnc2ccc(Br)cc12
Show InChI InChI=1S/C15H14BrNO2S/c16-10-3-4-12-11(9-10)13(5-8-17-12)20-15(14(18)19)6-1-2-7-15/h3-5,8-9H,1-2,6-7H2,(H,18,19)
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n/an/a 352n/an/an/an/an/an/a



SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; JIANGSU HENGRUI MEDICINE CO., LTD.

US Patent


Assay Description
In vitro URAT1 assay can be used to identify compounds having potential activity for decreasing serum uric acid. In a suitable test, the vectors that...


US Patent US9637484 (2017)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12 (URAT1)


(Homo sapiens (Human))
BDBM50134674
PNG
(CHEMBL3747747 | US9637484, 8)
Show SMILES OC(=O)C1(CCC1)Sc1ccnc2ccc(cc12)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H16F3NO2S/c22-21(23,24)15-4-1-3-13(11-15)14-5-6-17-16(12-14)18(7-10-25-17)28-20(19(26)27)8-2-9-20/h1,3-7,10-12H,2,8-9H2,(H,26,27)
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n/an/a 359n/an/an/an/an/an/a



SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; JIANGSU HENGRUI MEDICINE CO., LTD.

US Patent


Assay Description
In vitro URAT1 assay can be used to identify compounds having potential activity for decreasing serum uric acid. In a suitable test, the vectors that...


US Patent US9637484 (2017)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12 (URAT1)


(Homo sapiens (Human))
BDBM50134662
PNG
(CHEMBL3747493 | US9637484, 17)
Show SMILES OC(=O)C1(CCC1)Sc1ccnc2ccc(cc12)C#N
Show InChI InChI=1S/C15H12N2O2S/c16-9-10-2-3-12-11(8-10)13(4-7-17-12)20-15(14(18)19)5-1-6-15/h2-4,7-8H,1,5-6H2,(H,18,19)
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n/an/a 398n/an/an/an/an/an/a



SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; JIANGSU HENGRUI MEDICINE CO., LTD.

US Patent


Assay Description
In vitro URAT1 assay can be used to identify compounds having potential activity for decreasing serum uric acid. In a suitable test, the vectors that...


US Patent US9637484 (2017)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12 (URAT1)


(Homo sapiens (Human))
BDBM50134639
PNG
(CHEMBL3746433 | US9637484, 12)
Show SMILES OC(=O)C1(CCC1)Sc1ccnc2ccc(F)cc12
Show InChI InChI=1S/C14H12FNO2S/c15-9-2-3-11-10(8-9)12(4-7-16-11)19-14(13(17)18)5-1-6-14/h2-4,7-8H,1,5-6H2,(H,17,18)
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n/an/a 557n/an/an/an/an/an/a



SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; JIANGSU HENGRUI MEDICINE CO., LTD.

US Patent


Assay Description
In vitro URAT1 assay can be used to identify compounds having potential activity for decreasing serum uric acid. In a suitable test, the vectors that...


US Patent US9637484 (2017)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12 (URAT1)


(Homo sapiens (Human))
BDBM50134636
PNG
(CHEMBL3747353 | US9637484, 23)
Show SMILES OC(=O)C1(CCC1)Sc1ccnc2ccc(cc12)C1CC1
Show InChI InChI=1S/C17H17NO2S/c19-16(20)17(7-1-8-17)21-15-6-9-18-14-5-4-12(10-13(14)15)11-2-3-11/h4-6,9-11H,1-3,7-8H2,(H,19,20)
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n/an/a 658n/an/an/an/an/an/a



SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; JIANGSU HENGRUI MEDICINE CO., LTD.

US Patent


Assay Description
In vitro URAT1 assay can be used to identify compounds having potential activity for decreasing serum uric acid. In a suitable test, the vectors that...


US Patent US9637484 (2017)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12 (URAT1)


(Homo sapiens (Human))
BDBM50134646
PNG
(CHEMBL3746317 | US9637484, 24)
Show SMILES OC(=O)C1(CCC1)Sc1ccnc2ccc(OCC#N)cc12
Show InChI InChI=1S/C16H14N2O3S/c17-7-9-21-11-2-3-13-12(10-11)14(4-8-18-13)22-16(15(19)20)5-1-6-16/h2-4,8,10H,1,5-6,9H2,(H,19,20)
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n/an/a 680n/an/an/an/an/an/a



SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; JIANGSU HENGRUI MEDICINE CO., LTD.

US Patent


Assay Description
In vitro URAT1 assay can be used to identify compounds having potential activity for decreasing serum uric acid. In a suitable test, the vectors that...


US Patent US9637484 (2017)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 12 (URAT1)


(Homo sapiens (Human))
BDBM50134676
PNG
(CHEMBL3747094 | US9637484, 10)
Show SMILES OC(=O)C1(CCC1)Sc1ccc(C#N)c2ccccc12
Show InChI InChI=1S/C16H13NO2S/c17-10-11-6-7-14(13-5-2-1-4-12(11)13)20-16(15(18)19)8-3-9-16/h1-2,4-7H,3,8-9H2,(H,18,19)
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n/an/a 926n/an/an/an/an/an/a



SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; JIANGSU HENGRUI MEDICINE CO., LTD.

US Patent


Assay Description
In vitro URAT1 assay can be used to identify compounds having potential activity for decreasing serum uric acid. In a suitable test, the vectors that...


US Patent US9637484 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%