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Patent code US9637488

Compile Data Set for Download or QSAR
Found 37 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326285
PNG
(US9637488, 68)
Show SMILES Nc1nc(N)c(C#N)c(n1)N1CCCC1c1cc2cccc(Cl)c2nc1-c1ccccc1
Show InChI InChI=1S/C24H20ClN7/c25-18-9-4-8-15-12-16(20(29-21(15)18)14-6-2-1-3-7-14)19-10-5-11-32(19)23-17(13-26)22(27)30-24(28)31-23/h1-4,6-9,12,19H,5,10-11H2,(H4,27,28,30,31)
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n/an/a<0.0500n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326284
PNG
(US9637488, 67)
Show SMILES Nc1ncnc(N2CCCC2c2cc3cccc(Cl)c3nc2-c2ccccc2)c1C#N
Show InChI InChI=1S/C24H19ClN6/c25-19-9-4-8-16-12-17(21(30-22(16)19)15-6-2-1-3-7-15)20-10-5-11-31(20)24-18(13-26)23(27)28-14-29-24/h1-4,6-9,12,14,20H,5,10-11H2,(H2,27,28,29)
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TBA

US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326267
PNG
(US9637488, 27)
Show SMILES Nc1nc(N)c(C#N)c(n1)N1CCCC1c1cc2ccc(F)cc2nc1-c1ccccc1
Show InChI InChI=1S/C24H20FN7/c25-16-9-8-15-11-17(21(29-19(15)12-16)14-5-2-1-3-6-14)20-7-4-10-32(20)23-18(13-26)22(27)30-24(28)31-23/h1-3,5-6,8-9,11-12,20H,4,7,10H2,(H4,27,28,30,31)
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US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326282
PNG
(US9637488, 65)
Show SMILES Cc1cccc2cc([C@H]3CCCN3c3ncnc(N)c3C#N)c(nc12)N1CCOCC1
Show InChI InChI=1S/C23H25N7O/c1-15-4-2-5-16-12-17(23(28-20(15)16)29-8-10-31-11-9-29)19-6-3-7-30(19)22-18(13-24)21(25)26-14-27-22/h2,4-5,12,14,19H,3,6-11H2,1H3,(H2,25,26,27)/t19-/m1/s1
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US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326286
PNG
(US9637488, 69)
Show SMILES Nc1ncnc(N2CCC[C@@H]2c2cc3cccc(Cl)c3nc2N2CCOCC2)c1C#N
Show InChI InChI=1S/C22H22ClN7O/c23-17-4-1-3-14-11-15(22(28-19(14)17)29-7-9-31-10-8-29)18-5-2-6-30(18)21-16(12-24)20(25)26-13-27-21/h1,3-4,11,13,18H,2,5-10H2,(H2,25,26,27)/t18-/m1/s1
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Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326278
PNG
(US9637488, 54)
Show SMILES Nc1nc(N)c(C#N)c(n1)N1CCC[C@H]1c1cc2cccc(Cl)c2nc1-c1ccccc1
Show InChI InChI=1S/C24H20ClN7/c25-18-9-4-8-15-12-16(20(29-21(15)18)14-6-2-1-3-7-14)19-10-5-11-32(19)23-17(13-26)22(27)30-24(28)31-23/h1-4,6-9,12,19H,5,10-11H2,(H4,27,28,30,31)/t19-/m0/s1
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US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326259
PNG
(US9637488, 18)
Show SMILES Nc1ncnc(N2CCCC2c2cc3ccc(F)cc3nc2N2CCCCC2)c1C#N
Show InChI InChI=1S/C23H24FN7/c24-16-7-6-15-11-17(23(29-19(15)12-16)30-8-2-1-3-9-30)20-5-4-10-31(20)22-18(13-25)21(26)27-14-28-22/h6-7,11-12,14,20H,1-5,8-10H2,(H2,26,27,28)
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US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326262
PNG
(US9637488, 22 | US9637488, 24)
Show SMILES Fc1ccc2cc(C3CCCN3c3ncnc4[nH]cnc34)c(nc2c1)-c1ccccc1F
Show InChI InChI=1S/C24H18F2N6/c25-15-8-7-14-10-17(21(31-19(14)11-15)16-4-1-2-5-18(16)26)20-6-3-9-32(20)24-22-23(28-12-27-22)29-13-30-24/h1-2,4-5,7-8,10-13,20H,3,6,9H2,(H,27,28,29,30)
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Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326261
PNG
(US9637488, 21)
Show SMILES Fc1ccc2cc(C3CCCN3c3ncnc4[nH]cnc34)c(nc2c1)-c1ccccc1
Show InChI InChI=1S/C24H19FN6/c25-17-9-8-16-11-18(21(30-19(16)12-17)15-5-2-1-3-6-15)20-7-4-10-31(20)24-22-23(27-13-26-22)28-14-29-24/h1-3,5-6,8-9,11-14,20H,4,7,10H2,(H,26,27,28,29)
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US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326258
PNG
(US9637488, 17)
Show SMILES Cc1nc(N2CCCC2c2cc3ccc(F)cc3nc2N2CCCCC2)c2[nH]cnc2n1
Show InChI InChI=1S/C24H26FN7/c1-15-28-22-21(26-14-27-22)24(29-15)32-11-5-6-20(32)18-12-16-7-8-17(25)13-19(16)30-23(18)31-9-3-2-4-10-31/h7-8,12-14,20H,2-6,9-11H2,1H3,(H,26,27,28,29)
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US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326281
PNG
(US9637488, 64)
Show SMILES Cc1cccc2cc([C@H]3CCCN3c3ncnc4nc[nH]c34)c(nc12)N1CCOCC1
Show InChI InChI=1S/C23H25N7O/c1-15-4-2-5-16-12-17(22(28-19(15)16)29-8-10-31-11-9-29)18-6-3-7-30(18)23-20-21(25-13-24-20)26-14-27-23/h2,4-5,12-14,18H,3,6-11H2,1H3,(H,24,25,26,27)/t18-/m1/s1
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Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326252
PNG
(4-amino-6-(2-(7-fluoro-2-morpholinoquinolin-3-yl)p...)
Show SMILES Nc1ncnc(N2CCCC2c2cc3ccc(F)cc3nc2N2CCOCC2)c1C#N
Show InChI InChI=1S/C22H22FN7O/c23-15-4-3-14-10-16(22(28-18(14)11-15)29-6-8-31-9-7-29)19-2-1-5-30(19)21-17(12-24)20(25)26-13-27-21/h3-4,10-11,13,19H,1-2,5-9H2,(H2,25,26,27)
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Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326269
PNG
(US9637488, 29)
Show SMILES Nc1ncnc(N2CCCC2c2cc3ccc(F)cc3nc2-c2ccccc2)c1C#C
Show InChI InChI=1S/C25H20FN5/c1-2-19-24(27)28-15-29-25(19)31-12-6-9-22(31)20-13-17-10-11-18(26)14-21(17)30-23(20)16-7-4-3-5-8-16/h1,3-5,7-8,10-11,13-15,22H,6,9,12H2,(H2,27,28,29)
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Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326283
PNG
(US9637488, 66)
Show SMILES Clc1cccc2cc(C3CCCN3c3ncnc4[nH]cnc34)c(nc12)N1CCOCC1
Show InChI InChI=1S/C22H22ClN7O/c23-16-4-1-3-14-11-15(21(28-18(14)16)29-7-9-31-10-8-29)17-5-2-6-30(17)22-19-20(25-12-24-19)26-13-27-22/h1,3-4,11-13,17H,2,5-10H2,(H,24,25,26,27)
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Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326257
PNG
(US9637488, 16)
Show SMILES Fc1ccc2cc(C3CCCN3c3ncnc4nc[nH]c34)c(nc2c1)-c1ccccn1
Show InChI InChI=1S/C23H18FN7/c24-15-7-6-14-10-16(20(30-18(14)11-15)17-4-1-2-8-25-17)19-5-3-9-31(19)23-21-22(27-12-26-21)28-13-29-23/h1-2,4,6-8,10-13,19H,3,5,9H2,(H,26,27,28,29)
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Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25045
PNG
(3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin...)
Show SMILES Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1
Show InChI InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2
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Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326270
PNG
(US9637488, 30)
Show SMILES COc1ccccc1-c1nc2cc(F)ccc2cc1C1CCCN1c1ncnc(N)c1C#C
Show InChI InChI=1S/C26H22FN5O/c1-3-18-25(28)29-15-30-26(18)32-12-6-8-22(32)20-13-16-10-11-17(27)14-21(16)31-24(20)19-7-4-5-9-23(19)33-2/h1,4-5,7,9-11,13-15,22H,6,8,12H2,2H3,(H2,28,29,30)
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Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326276
PNG
(US9637488, 44)
Show SMILES Nc1ncnc(N2CCCCC2c2cc3ccc(F)cc3nc2N2CCOCC2)c1C#N
Show InChI InChI=1S/C23H24FN7O/c24-16-5-4-15-11-17(23(29-19(15)12-16)30-7-9-32-10-8-30)20-3-1-2-6-31(20)22-18(13-25)21(26)27-14-28-22/h4-5,11-12,14,20H,1-3,6-10H2,(H2,26,27,28)
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Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326272
PNG
(US9637488, 38 | US9637488, 43)
Show SMILES Fc1ccc2cc(C3CCCCN3c3ncnc4[nH]cnc34)c(nc2c1)N1CCOCC1
Show InChI InChI=1S/C23H24FN7O/c24-16-5-4-15-11-17(22(29-18(15)12-16)30-7-9-32-10-8-30)19-3-1-2-6-31(19)23-20-21(26-13-25-20)27-14-28-23/h4-5,11-14,19H,1-3,6-10H2,(H,25,26,27,28)
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Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326272
PNG
(US9637488, 38 | US9637488, 43)
Show SMILES Fc1ccc2cc(C3CCCCN3c3ncnc4[nH]cnc34)c(nc2c1)N1CCOCC1
Show InChI InChI=1S/C23H24FN7O/c24-16-5-4-15-11-17(22(29-18(15)12-16)30-7-9-32-10-8-30)19-3-1-2-6-31(19)23-20-21(26-13-25-20)27-14-28-23/h4-5,11-14,19H,1-3,6-10H2,(H,25,26,27,28)
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US Patent
n/an/a 7.10n/an/an/an/an/an/a



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US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326263
PNG
(US9637488, 23 | US9637488, 25)
Show SMILES COc1ccccc1-c1nc2cc(F)ccc2cc1C1CCCN1c1ncnc2[nH]cnc12
Show InChI InChI=1S/C25H21FN6O/c1-33-21-7-3-2-5-17(21)22-18(11-15-8-9-16(26)12-19(15)31-22)20-6-4-10-32(20)25-23-24(28-13-27-23)29-14-30-25/h2-3,5,7-9,11-14,20H,4,6,10H2,1H3,(H,27,28,29,30)
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n/an/a 11n/an/an/an/an/an/a



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US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326279
PNG
(US9637488, 62)
Show SMILES Fc1ccc2cc([C@H]3CCCN3c3ncnc4[nH]cnc34)c(nc2c1)-c1ccccn1
Show InChI InChI=1S/C23H18FN7/c24-15-7-6-14-10-16(20(30-18(14)11-15)17-4-1-2-8-25-17)19-5-3-9-31(19)23-21-22(27-12-26-21)28-13-29-23/h1-2,4,6-8,10-13,19H,3,5,9H2,(H,26,27,28,29)/t19-/m1/s1
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n/an/a 12.8n/an/an/an/an/an/a



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US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326253
PNG
(3-(1-(9H-purin-6-yl)pyrrolidin-2-yl)-7-fluoro-2-(p...)
Show SMILES Fc1ccc2cc(C3CCCN3c3ncnc4[nH]cnc34)c(nc2c1)-c1ccccn1
Show InChI InChI=1S/C23H18FN7/c24-15-7-6-14-10-16(20(30-18(14)11-15)17-4-1-2-8-25-17)19-5-3-9-31(19)23-21-22(27-12-26-21)28-13-29-23/h1-2,4,6-8,10-13,19H,3,5,9H2,(H,26,27,28,29)
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n/an/a 13n/an/an/an/an/an/a



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US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326263
PNG
(US9637488, 23 | US9637488, 25)
Show SMILES COc1ccccc1-c1nc2cc(F)ccc2cc1C1CCCN1c1ncnc2[nH]cnc12
Show InChI InChI=1S/C25H21FN6O/c1-33-21-7-3-2-5-17(21)22-18(11-15-8-9-16(26)12-19(15)31-22)20-6-4-10-32(20)25-23-24(28-13-27-23)29-14-30-25/h2-3,5,7-9,11-14,20H,4,6,10H2,1H3,(H,27,28,29,30)
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n/an/a 14n/an/an/an/an/an/a



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US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326262
PNG
(US9637488, 22 | US9637488, 24)
Show SMILES Fc1ccc2cc(C3CCCN3c3ncnc4[nH]cnc34)c(nc2c1)-c1ccccc1F
Show InChI InChI=1S/C24H18F2N6/c25-15-8-7-14-10-17(21(31-19(14)11-15)16-4-1-2-5-18(16)26)20-6-3-9-32(20)24-22-23(28-12-27-22)29-13-30-24/h1-2,4-5,7-8,10-13,20H,3,6,9H2,(H,27,28,29,30)
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n/an/a 16n/an/an/an/an/an/a



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US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326280
PNG
(US9637488, 63)
Show SMILES Cc1cccc2cc(C3CCCN3c3ncnc4[nH]cnc34)c(nc12)-c1ccccc1
Show InChI InChI=1S/C25H22N6/c1-16-7-5-10-18-13-19(22(30-21(16)18)17-8-3-2-4-9-17)20-11-6-12-31(20)25-23-24(27-14-26-23)28-15-29-25/h2-5,7-10,13-15,20H,6,11-12H2,1H3,(H,26,27,28,29)
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n/an/a 18n/an/an/an/an/an/a



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US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326260
PNG
(US9637488, 20)
Show SMILES Fc1ccc2cc(C3CCCN3c3ncnc4[nH]cnc34)c(nc2c1)N1CCOCC1
Show InChI InChI=1S/C22H22FN7O/c23-15-4-3-14-10-16(21(28-17(14)11-15)29-6-8-31-9-7-29)18-2-1-5-30(18)22-19-20(25-12-24-19)26-13-27-22/h3-4,10-13,18H,1-2,5-9H2,(H,24,25,26,27)
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n/an/a 19n/an/an/an/an/an/a



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US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326251
PNG
(3-(1-(9H-purin-6-yl)pyrrolidin-2-yl)-7-fluoro-2-(p...)
Show SMILES Fc1ccc2cc(C3CCCN3c3ncnc4[nH]cnc34)c(nc2c1)-c1cccnc1
Show InChI InChI=1S/C23H18FN7/c24-16-6-5-14-9-17(20(30-18(14)10-16)15-3-1-7-25-11-15)19-4-2-8-31(19)23-21-22(27-12-26-21)28-13-29-23/h1,3,5-7,9-13,19H,2,4,8H2,(H,26,27,28,29)
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n/an/a 27n/an/an/an/an/an/a



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US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326274
PNG
(US9637488, 42)
Show SMILES Nc1ncnc(N2CCCCC2c2cc3ccc(F)cc3nc2-c2ccccc2)c1C#N
Show InChI InChI=1S/C25H21FN6/c26-18-10-9-17-12-19(23(31-21(17)13-18)16-6-2-1-3-7-16)22-8-4-5-11-32(22)25-20(14-27)24(28)29-15-30-25/h1-3,6-7,9-10,12-13,15,22H,4-5,8,11H2,(H2,28,29,30)
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n/an/a 55n/an/an/an/an/an/a



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US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326256
PNG
(US9637488, 15)
Show SMILES Nc1ncnc(N2CCCC2c2cc3ccc(F)cc3nc2-c2ccccn2)c1C#N
Show InChI InChI=1S/C23H18FN7/c24-15-7-6-14-10-16(21(30-19(14)11-15)18-4-1-2-8-27-18)20-5-3-9-31(20)23-17(12-25)22(26)28-13-29-23/h1-2,4,6-8,10-11,13,20H,3,5,9H2,(H2,26,28,29)
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n/an/a 62n/an/an/an/an/an/a



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US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326271
PNG
(US9637488, 31)
Show SMILES Fc1ccc2cc(C3CC=CCN3c3ncnc4[nH]cnc34)c(nc2c1)-c1ccccc1
Show InChI InChI=1S/C25H19FN6/c26-18-10-9-17-12-19(22(31-20(17)13-18)16-6-2-1-3-7-16)21-8-4-5-11-32(21)25-23-24(28-14-27-23)29-15-30-25/h1-7,9-10,12-15,21H,8,11H2,(H,27,28,29,30)
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n/an/a 103n/an/an/an/an/an/a



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US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326266
PNG
(US9637488, 26)
Show SMILES Fc1ccc2cc(C3CCCN3c3ncnc4[nH]cnc34)c(nc2c1)-c1ccccc1OC(F)(F)F
Show InChI InChI=1S/C25H18F4N6O/c26-15-8-7-14-10-17(19-5-3-9-35(19)24-22-23(31-12-30-22)32-13-33-24)21(34-18(14)11-15)16-4-1-2-6-20(16)36-25(27,28)29/h1-2,4,6-8,10-13,19H,3,5,9H2,(H,30,31,32,33)
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n/an/a 207n/an/an/an/an/an/a



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US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326273
PNG
(US9637488, 41)
Show SMILES Fc1ccc2cc(C3CCCCN3c3ncnc4[nH]cnc34)c(nc2c1)-c1ccccc1
Show InChI InChI=1S/C25H21FN6/c26-18-10-9-17-12-19(22(31-20(17)13-18)16-6-2-1-3-7-16)21-8-4-5-11-32(21)25-23-24(28-14-27-23)29-15-30-25/h1-3,6-7,9-10,12-15,21H,4-5,8,11H2,(H,27,28,29,30)
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n/an/a 240n/an/an/an/an/an/a



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US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326253
PNG
(3-(1-(9H-purin-6-yl)pyrrolidin-2-yl)-7-fluoro-2-(p...)
Show SMILES Fc1ccc2cc(C3CCCN3c3ncnc4[nH]cnc34)c(nc2c1)-c1ccccn1
Show InChI InChI=1S/C23H18FN7/c24-15-7-6-14-10-16(20(30-18(14)11-15)17-4-1-2-8-25-17)19-5-3-9-31(19)23-21-22(27-12-26-21)28-13-29-23/h1-2,4,6-8,10-13,19H,3,5,9H2,(H,26,27,28,29)
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n/an/a 521n/an/an/an/an/an/a



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US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326268
PNG
(US9637488, 28)
Show SMILES Nc1cc(nc(N)n1)N1CCCC1c1cc2ccc(F)cc2nc1-c1ccccc1
Show InChI InChI=1S/C23H21FN6/c24-16-9-8-15-11-17(22(27-18(15)12-16)14-5-2-1-3-6-14)19-7-4-10-30(19)21-13-20(25)28-23(26)29-21/h1-3,5-6,8-9,11-13,19H,4,7,10H2,(H4,25,26,28,29)
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n/an/a>1.00E+3n/an/an/an/an/an/a



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US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326254
PNG
(US9637488, 13)
Show SMILES Cn1c2ncnc(N3CCCC3c3cc4ccc(F)cc4nc3-c3ccccn3)c2n(C)c1=O
Show InChI InChI=1S/C25H22FN7O/c1-31-22-23(32(2)25(31)34)28-14-29-24(22)33-11-5-7-20(33)17-12-15-8-9-16(26)13-19(15)30-21(17)18-6-3-4-10-27-18/h3-4,6,8-10,12-14,20H,5,7,11H2,1-2H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



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US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM326277
PNG
(US9637488, 45)
Show SMILES Fc1ccc2cc(C3CCCCCN3c3ncnc4[nH]cnc34)c(nc2c1)-c1ccccc1
Show InChI InChI=1S/C26H23FN6/c27-19-11-10-18-13-20(23(32-21(18)14-19)17-7-3-1-4-8-17)22-9-5-2-6-12-33(22)26-24-25(29-15-28-24)30-16-31-26/h1,3-4,7-8,10-11,13-16,22H,2,5-6,9,12H2,(H,28,29,30,31)
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n/an/a>1.00E+3n/an/an/an/an/an/a



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US Patent


Assay Description
Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...


US Patent US9637488 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%