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Patent code US9637493

Compile Data Set for Download or QSAR
Found 47 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


()
BDBM326330
PNG
(4-(5-chloropyridin-3-yl)-6- [(1R or S)-1-fluoro-1-...)
Show SMILES C[C@H]1CC[C@H](Cn2c(cc3nc(nc(-c4cncc(Cl)c4)c23)C(O)=O)C(C)(F)c2ncccc2F)CC1
Show InChI InChI=1S/C27H26ClF2N5O2/c1-15-5-7-16(8-6-15)14-35-21(27(2,30)24-19(29)4-3-9-32-24)11-20-23(35)22(34-25(33-20)26(36)37)17-10-18(28)13-31-12-17/h3-4,9-13,15-16H,5-8,14H2,1-2H3,(H,36,37)/t15-,16-,27?
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326332
PNG
(3-{4-(5-chloropyridin-3- yl)-6-[(1R or S)-1-fluoro...)
Show SMILES C[C@H]1CC[C@H](Cn2c(cc3nc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)C(C)(F)c2ncccc2F)CC1
Show InChI InChI=1S/C28H26ClF2N7O2/c1-15-5-7-16(8-6-15)14-38-21(28(2,31)24-19(30)4-3-9-33-24)11-20-23(38)22(17-10-18(29)13-32-12-17)35-25(34-20)26-36-27(39)40-37-26/h3-4,9-13,15-16H,5-8,14H2,1-2H3,(H,36,37,39)/t15-,16-,28?
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326329
PNG
(3-{4-(5-chloropyridin-3- yl)-6-[fluoro(2- fluoroph...)
Show SMILES C[C@H]1CC[C@H](Cn2c(cc3nc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)C(F)c2ccccc2F)CC1
Show InChI InChI=1S/C28H25ClF2N6O2/c1-15-6-8-16(9-7-15)14-37-22(23(31)19-4-2-3-5-20(19)30)11-21-25(37)24(17-10-18(29)13-32-12-17)34-26(33-21)27-35-28(38)39-36-27/h2-5,10-13,15-16,23H,6-9,14H2,1H3,(H,35,36,38)/t15-,16-,23?
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326328
PNG
(4-(5-chloropyridin-3-yl)-6- [fluoro(2- fluoropheny...)
Show SMILES C[C@H]1CC[C@H](Cn2c(cc3nc(nc(-c4cncc(Cl)c4)c23)C(O)=O)C(F)c2ccccc2F)CC1
Show InChI InChI=1S/C27H25ClF2N4O2/c1-15-6-8-16(9-7-15)14-34-22(23(30)19-4-2-3-5-20(19)29)11-21-25(34)24(33-26(32-21)27(35)36)17-10-18(28)13-31-12-17/h2-5,10-13,15-16,23H,6-9,14H2,1H3,(H,35,36)/t15-,16-,23?
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326332
PNG
(3-{4-(5-chloropyridin-3- yl)-6-[(1R or S)-1-fluoro...)
Show SMILES C[C@H]1CC[C@H](Cn2c(cc3nc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)C(C)(F)c2ncccc2F)CC1
Show InChI InChI=1S/C28H26ClF2N7O2/c1-15-5-7-16(8-6-15)14-38-21(28(2,31)24-19(30)4-3-9-33-24)11-20-23(38)22(17-10-18(29)13-32-12-17)35-25(34-20)26-36-27(39)40-37-26/h3-4,9-13,15-16H,5-8,14H2,1-2H3,(H,36,37,39)/t15-,16-,28?
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326330
PNG
(4-(5-chloropyridin-3-yl)-6- [(1R or S)-1-fluoro-1-...)
Show SMILES C[C@H]1CC[C@H](Cn2c(cc3nc(nc(-c4cncc(Cl)c4)c23)C(O)=O)C(C)(F)c2ncccc2F)CC1
Show InChI InChI=1S/C27H26ClF2N5O2/c1-15-5-7-16(8-6-15)14-35-21(27(2,30)24-19(29)4-3-9-32-24)11-20-23(35)22(34-25(33-20)26(36)37)17-10-18(28)13-31-12-17/h3-4,9-13,15-16H,5-8,14H2,1-2H3,(H,36,37)/t15-,16-,27?
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326298
PNG
(5-[2-amino-4- (trifluoromethyl) benzyl]-4-{[(1R)-1...)
Show SMILES C[C@@H](Nc1nc(nc2cc(-c3cccc(C)c3)n(Cc3ccc(cc3N)C(F)(F)F)c12)C(O)=O)C1CCC1
Show InChI InChI=1S/C28H28F3N5O2/c1-15-5-3-8-18(11-15)23-13-22-24(36(23)14-19-9-10-20(12-21(19)32)28(29,30)31)25(35-26(34-22)27(37)38)33-16(2)17-6-4-7-17/h3,5,8-13,16-17H,4,6-7,14,32H2,1-2H3,(H,37,38)(H,33,34,35)/t16-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326326
PNG
(3-[4-(5-chloropyridin-3- yl)-5-[(trans-4- methylcy...)
Show SMILES C[C@H]1CC[C@H](Cn2cc(CCc3cccnc3)c3nc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)CC1
Show InChI InChI=1S/C28H28ClN7O2/c1-17-4-6-19(7-5-17)15-36-16-20(9-8-18-3-2-10-30-12-18)23-25(36)24(21-11-22(29)14-31-13-21)33-26(32-23)27-34-28(37)38-35-27/h2-3,10-14,16-17,19H,4-9,15H2,1H3,(H,34,35,37)/t17-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326309
PNG
(5-(4-bromo-3- fluorobenzyl)-4-{[(1R)- 1- cyclobuty...)
Show SMILES C[C@@H](Nc1nc(nc2cc(-c3cccc(C)c3)n(Cc3ccc(Br)c(F)c3)c12)C(O)=O)C1CCC1
Show InChI InChI=1S/C27H26BrFN4O2/c1-15-5-3-8-19(11-15)23-13-22-24(33(23)14-17-9-10-20(28)21(29)12-17)25(32-26(31-22)27(34)35)30-16(2)18-6-4-7-18/h3,5,8-13,16,18H,4,6-7,14H2,1-2H3,(H,34,35)(H,30,31,32)/t16-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326295
PNG
(4-{[(1R)-1- cyclobutylethyl]amino}- 6-(4-methylpyr...)
Show SMILES C[C@@H](Nc1nc(nc2cc(-c3cc(C)ccn3)n(Cc3ccc(cc3)C(F)(F)F)c12)C(O)=O)C1CCC1
Show InChI InChI=1S/C27H26F3N5O2/c1-15-10-11-31-20(12-15)22-13-21-23(35(22)14-17-6-8-19(9-7-17)27(28,29)30)24(34-25(33-21)26(36)37)32-16(2)18-4-3-5-18/h6-13,16,18H,3-5,14H2,1-2H3,(H,36,37)(H,32,33,34)/t16-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326306
PNG
(5-(4-chloro-3- fluorobenzyl)-4-{[(1R)- 1- cyclobut...)
Show SMILES C[C@@H](Nc1nc(nc2cc(-c3cccc(C)c3)n(Cc3ccc(Cl)c(F)c3)c12)C(O)=O)C1CCC1
Show InChI InChI=1S/C27H26ClFN4O2/c1-15-5-3-8-19(11-15)23-13-22-24(33(23)14-17-9-10-20(28)21(29)12-17)25(32-26(31-22)27(34)35)30-16(2)18-6-4-7-18/h3,5,8-13,16,18H,4,6-7,14H2,1-2H3,(H,34,35)(H,30,31,32)/t16-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326296
PNG
(4-{[(1R)-1- cyclobutylethyl]amino}- 6-[4-(1- methy...)
Show SMILES CC(C)c1ccnc(c1)-c1cc2nc(nc(N[C@H](C)C3CCC3)c2n1Cc1ccc(cc1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C29H30F3N5O2/c1-16(2)20-11-12-33-22(13-20)24-14-23-25(37(24)15-18-7-9-21(10-8-18)29(30,31)32)26(36-27(35-23)28(38)39)34-17(3)19-5-4-6-19/h7-14,16-17,19H,4-6,15H2,1-3H3,(H,38,39)(H,34,35,36)/t17-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326324
PNG
(3-[4-(5-chloropyridin-3- yl)-5-[(trans-4- methylcy...)
Show SMILES CC(C)Cc1cn(C[C@H]2CC[C@H](C)CC2)c2c(nc(nc12)-c1noc(=O)[nH]1)-c1cncc(Cl)c1
Show InChI InChI=1S/C25H29ClN6O2/c1-14(2)8-18-13-32(12-16-6-4-15(3)5-7-16)22-20(17-9-19(26)11-27-10-17)28-23(29-21(18)22)24-30-25(33)34-31-24/h9-11,13-16H,4-8,12H2,1-3H3,(H,30,31,33)/t15-,16-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326320
PNG
(3-{4-(5-chloropyridin-3- yl)-7-methyl-5-[(trans-4-...)
Show SMILES C[C@H]1CC[C@H](Cn2cc(C)c3nc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)CC1
Show InChI InChI=1S/C22H23ClN6O2/c1-12-3-5-14(6-4-12)11-29-10-13(2)17-19(29)18(15-7-16(23)9-24-8-15)26-20(25-17)21-27-22(30)31-28-21/h7-10,12,14H,3-6,11H2,1-2H3,(H,27,28,30)/t12-,14-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326291
PNG
(4-{[(1R)-1- cyclobutylethyl]amino}- 6-(2-methoxy-5...)
Show SMILES COc1ccc(C)cc1-c1cc2nc(nc(N[C@H](C)C3CCC3)c2n1Cc1ccc(cc1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C29H29F3N4O3/c1-16-7-12-24(39-3)21(13-16)23-14-22-25(36(23)15-18-8-10-20(11-9-18)29(30,31)32)26(35-27(34-22)28(37)38)33-17(2)19-5-4-6-19/h7-14,17,19H,4-6,15H2,1-3H3,(H,37,38)(H,33,34,35)/t17-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326325
PNG
(4-(5-chloropyridin-3-yl)-5- [(trans-4- methylcyclo...)
Show SMILES C[C@H]1CC[C@H](Cn2cc(CCc3cccnc3)c3nc(nc(-c4cncc(Cl)c4)c23)C(O)=O)CC1
Show InChI InChI=1S/C27H28ClN5O2/c1-17-4-6-19(7-5-17)15-33-16-20(9-8-18-3-2-10-29-12-18)23-25(33)24(32-26(31-23)27(34)35)21-11-22(28)14-30-13-21/h2-3,10-14,16-17,19H,4-9,15H2,1H3,(H,34,35)/t17-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326297
PNG
(4-{[(1R)-1- cyclobutylethyl]amino}- 7-methyl-6-[4-...)
Show SMILES CC(C)c1ccnc(c1)-c1c(C)c2nc(nc(N[C@H](C)C3CCC3)c2n1Cc1ccc(cc1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C30H32F3N5O2/c1-16(2)21-12-13-34-23(14-21)25-17(3)24-26(38(25)15-19-8-10-22(11-9-19)30(31,32)33)27(37-28(36-24)29(39)40)35-18(4)20-6-5-7-20/h8-14,16,18,20H,5-7,15H2,1-4H3,(H,39,40)(H,35,36,37)/t18-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326327
PNG
(3-[4-(5-chloropyridin-3- yl)-5-[(trans-4- methylcy...)
Show SMILES C[C@H]1CC[C@H](Cn2cc(Cc3cccnc3)c3nc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)CC1
Show InChI InChI=1S/C27H26ClN7O2/c1-16-4-6-17(7-5-16)14-35-15-20(9-18-3-2-8-29-11-18)23-24(35)22(19-10-21(28)13-30-12-19)31-25(32-23)26-33-27(36)37-34-26/h2-3,8,10-13,15-17H,4-7,9,14H2,1H3,(H,33,34,36)/t16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326322
PNG
(5-{7-benzyl-4-(5- chloropyridin-3-yl)-5- [(trans-4...)
Show SMILES C[C@H]1CC[C@H](Cn2cc(Cc3ccccc3)c3nc(nc(-c4cncc(Cl)c4)c23)-c2n[nH]c(=O)o2)CC1
Show InChI InChI=1S/C28H27ClN6O2/c1-17-7-9-19(10-8-17)15-35-16-21(11-18-5-3-2-4-6-18)24-25(35)23(20-12-22(29)14-30-13-20)31-26(32-24)27-33-34-28(36)37-27/h2-6,12-14,16-17,19H,7-11,15H2,1H3,(H,34,36)/t17-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326315
PNG
(3-{4-(5-chloropyridin-3- yl)-5-[(trans-4- methylcy...)
Show SMILES C[C@H]1CC[C@H](Cn2ccc3nc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)CC1
Show InChI InChI=1S/C21H21ClN6O2/c1-12-2-4-13(5-3-12)11-28-7-6-16-18(28)17(14-8-15(22)10-23-9-14)25-19(24-16)20-26-21(29)30-27-20/h6-10,12-13H,2-5,11H2,1H3,(H,26,27,29)/t12-,13-
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n/an/a 57n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326287
PNG
((R)-4-((1- cyclobutylethyl)amino)- 6-(2-fluoro-5- ...)
Show SMILES C[C@@H](Nc1nc(nc2cc(-c3cc(C)ccc3F)n(Cc3ccc(cc3)C(F)(F)F)c12)C(O)=O)C1CCC1
Show InChI InChI=1S/C28H26F4N4O2/c1-15-6-11-21(29)20(12-15)23-13-22-24(36(23)14-17-7-9-19(10-8-17)28(30,31)32)25(35-26(34-22)27(37)38)33-16(2)18-4-3-5-18/h6-13,16,18H,3-5,14H2,1-2H3,(H,37,38)(H,33,34,35)/t16-/m1/s1
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n/an/a 62n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326293
PNG
(6-(2-chloro-5- methylphenyl)-4-{[(1R)- 1- cyclobut...)
Show SMILES C[C@@H](Nc1nc(nc2cc(-c3cc(C)ccc3Cl)n(Cc3ccc(cc3)C(F)(F)F)c12)C(O)=O)C1CCC1
Show InChI InChI=1S/C28H26ClF3N4O2/c1-15-6-11-21(29)20(12-15)23-13-22-24(36(23)14-17-7-9-19(10-8-17)28(30,31)32)25(35-26(34-22)27(37)38)33-16(2)18-4-3-5-18/h6-13,16,18H,3-5,14H2,1-2H3,(H,37,38)(H,33,34,35)/t16-/m1/s1
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n/an/a 63n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326323
PNG
(4-(5-chloropyridin-3-yl)-5- [(trans-4- methylcyclo...)
Show SMILES CC(C)Cc1cn(C[C@H]2CC[C@H](C)CC2)c2c(nc(nc12)C(O)=O)-c1cncc(Cl)c1
Show InChI InChI=1S/C24H29ClN4O2/c1-14(2)8-18-13-29(12-16-6-4-15(3)5-7-16)22-20(17-9-19(25)11-26-10-17)27-23(24(30)31)28-21(18)22/h9-11,13-16H,4-8,12H2,1-3H3,(H,30,31)/t15-,16-
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n/an/a 71n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326321
PNG
(4-(5-chloropyridin-3-yl)-5- [(trans-4- methylcyclo...)
Show SMILES C[C@H]1CC[C@H](Cn2cc(-c3ccccc3)c3nc(nc(-c4cncc(Cl)c4)c23)C(O)=O)CC1
Show InChI InChI=1S/C26H25ClN4O2/c1-16-7-9-17(10-8-16)14-31-15-21(18-5-3-2-4-6-18)23-24(31)22(29-25(30-23)26(32)33)19-11-20(27)13-28-12-19/h2-6,11-13,15-17H,7-10,14H2,1H3,(H,32,33)/t16-,17-
PDB

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n/an/a 72n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326304
PNG
(4-{[(1R)-1- cyclobutylethyl] amino}-5-[3-fluoro-4-...)
Show SMILES C[C@@H](Nc1nc(nc2cc(-c3cccc(C)c3)n(Cc3ccc(c(F)c3)C(F)(F)F)c12)C(O)=O)C1CCC1
Show InChI InChI=1S/C28H26F4N4O2/c1-15-5-3-8-19(11-15)23-13-22-24(36(23)14-17-9-10-20(21(29)12-17)28(30,31)32)25(35-26(34-22)27(37)38)33-16(2)18-6-4-7-18/h3,5,8-13,16,18H,4,6-7,14H2,1-2H3,(H,37,38)(H,33,34,35)/t16-/m1/s1
PDB

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n/an/a 87n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326319
PNG
(4-(5-chloropyridin-3-yl)-7- methyl-5-[(trans-4- me...)
Show SMILES C[C@H]1CC[C@H](Cn2cc(C)c3nc(nc(-c4cncc(Cl)c4)c23)C(O)=O)CC1
Show InChI InChI=1S/C21H23ClN4O2/c1-12-3-5-14(6-4-12)11-26-10-13(2)17-19(26)18(25-20(24-17)21(27)28)15-7-16(22)9-23-8-15/h7-10,12,14H,3-6,11H2,1-2H3,(H,27,28)/t12-,14-
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n/an/a 88n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326316
PNG
(5-{4-(5-chloropyridin-3- yl)-5-[(trans-4- methylcy...)
Show SMILES C[C@H]1CC[C@H](Cn2ccc3nc(nc(-c4cncc(Cl)c4)c23)-c2n[nH]c(=O)o2)CC1
Show InChI InChI=1S/C21H21ClN6O2/c1-12-2-4-13(5-3-12)11-28-7-6-16-18(28)17(14-8-15(22)10-23-9-14)25-19(24-16)20-26-27-21(29)30-20/h6-10,12-13H,2-5,11H2,1H3,(H,27,29)/t12-,13-
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n/an/a 95n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326292
PNG
(6-(1-benzofuran-5-yl)- 4-{[(1R)-1- cyclobutylethyl...)
Show SMILES C[C@@H](Nc1nc(nc2cc(-c3ccc4occc4c3)n(Cc3ccc(cc3)C(F)(F)F)c12)C(O)=O)C1CCC1
Show InChI InChI=1S/C29H25F3N4O3/c1-16(18-3-2-4-18)33-26-25-22(34-27(35-26)28(37)38)14-23(19-7-10-24-20(13-19)11-12-39-24)36(25)15-17-5-8-21(9-6-17)29(30,31)32/h5-14,16,18H,2-4,15H2,1H3,(H,37,38)(H,33,34,35)/t16-/m1/s1
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n/an/a 105n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326318
PNG
(3-{4-(3-chlorophenyl)-7- methyl-5-[(trans-4- methy...)
Show SMILES C[C@H]1CC[C@H](Cn2cc(C)c3nc(nc(-c4cccc(Cl)c4)c23)-c2noc(=O)[nH]2)CC1
Show InChI InChI=1S/C23H24ClN5O2/c1-13-6-8-15(9-7-13)12-29-11-14(2)18-20(29)19(16-4-3-5-17(24)10-16)26-21(25-18)22-27-23(30)31-28-22/h3-5,10-11,13,15H,6-9,12H2,1-2H3,(H,27,28,30)/t13-,15-
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n/an/a 107n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326311
PNG
(4-{[(1R)-1- cyclobutylethyl]amino}- 5-(3-fluoro-4-...)
Show SMILES C[C@@H](Nc1nc(nc2cc(-c3cccc(C)c3)n(Cc3ccc(C)c(F)c3)c12)C(O)=O)C1CCC1
Show InChI InChI=1S/C28H29FN4O2/c1-16-6-4-9-21(12-16)24-14-23-25(33(24)15-19-11-10-17(2)22(29)13-19)26(32-27(31-23)28(34)35)30-18(3)20-7-5-8-20/h4,6,9-14,18,20H,5,7-8,15H2,1-3H3,(H,34,35)(H,30,31,32)/t18-/m1/s1
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n/an/a 124n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326310
PNG
(4-{[(1R)-1- cyclobutylethyl]amino}- 5-(3,4-difluor...)
Show SMILES C[C@@H](Nc1nc(nc2cc(-c3cccc(C)c3)n(Cc3ccc(F)c(F)c3)c12)C(O)=O)C1CCC1
Show InChI InChI=1S/C27H26F2N4O2/c1-15-5-3-8-19(11-15)23-13-22-24(33(23)14-17-9-10-20(28)21(29)12-17)25(32-26(31-22)27(34)35)30-16(2)18-6-4-7-18/h3,5,8-13,16,18H,4,6-7,14H2,1-2H3,(H,34,35)(H,30,31,32)/t16-/m1/s1
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n/an/a 126n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326290
PNG
((R)-4-((1- cyclobutylethyl)amino)- 7-methyl-6-(m-t...)
Show SMILES C[C@@H](Nc1nc(nc2c(C)c(-c3cccc(C)c3)n(Cc3ccc(cc3)C(F)(F)F)c12)C(O)=O)C1CCC1
Show InChI InChI=1S/C29H29F3N4O2/c1-16-6-4-9-21(14-16)24-17(2)23-25(36(24)15-19-10-12-22(13-11-19)29(30,31)32)26(35-27(34-23)28(37)38)33-18(3)20-7-5-8-20/h4,6,9-14,18,20H,5,7-8,15H2,1-3H3,(H,37,38)(H,33,34,35)/t18-/m1/s1
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n/an/a 130n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326313
PNG
(3-{4-(3-chlorophenyl)-5- [(trans-4- methylcyclohex...)
Show SMILES C[C@H]1CC[C@H](Cn2ccc3nc(nc(-c4cccc(Cl)c4)c23)-c2noc(=O)[nH]2)CC1
Show InChI InChI=1S/C22H22ClN5O2/c1-13-5-7-14(8-6-13)12-28-10-9-17-19(28)18(15-3-2-4-16(23)11-15)25-20(24-17)21-26-22(29)30-27-21/h2-4,9-11,13-14H,5-8,12H2,1H3,(H,26,27,29)/t13-,14-
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n/an/a 132n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326289
PNG
((R)-4-((1- cyclobutylethyl) amino)- 6-(m-tolyl)-5-...)
Show SMILES C[C@@H](Nc1nc(nc2cc(-c3cccc(C)c3)n(Cc3ccc(cc3)C(F)(F)F)c12)C(O)=O)C1CCC1
Show InChI InChI=1S/C28H27F3N4O2/c1-16-5-3-8-20(13-16)23-14-22-24(35(23)15-18-9-11-21(12-10-18)28(29,30)31)25(34-26(33-22)27(36)37)32-17(2)19-6-4-7-19/h3,5,8-14,17,19H,4,6-7,15H2,1-2H3,(H,36,37)(H,32,33,34)/t17-/m1/s1
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n/an/a 140n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326308
PNG
(4-{[(1R)-1- cyclobutylethyl]amino}- 6-(3-methylphe...)
Show SMILES C[C@@H](Nc1nc(nc2cc(-c3cccc(C)c3)n(Cc3ccc(nc3)C(F)(F)F)c12)C(O)=O)C1CCC1
Show InChI InChI=1S/C27H26F3N5O2/c1-15-5-3-8-19(11-15)21-12-20-23(35(21)14-17-9-10-22(31-13-17)27(28,29)30)24(34-25(33-20)26(36)37)32-16(2)18-6-4-7-18/h3,5,8-13,16,18H,4,6-7,14H2,1-2H3,(H,36,37)(H,32,33,34)/t16-/m1/s1
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n/an/a 178n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326317
PNG
(4-(3-chlorophenyl)-7- methyl-5-[(trans-4- methylcy...)
Show SMILES C[C@H]1CC[C@H](Cn2cc(C)c3nc(nc(-c4cccc(Cl)c4)c23)C(O)=O)CC1
Show InChI InChI=1S/C22H24ClN3O2/c1-13-6-8-15(9-7-13)12-26-11-14(2)18-20(26)19(25-21(24-18)22(27)28)16-4-3-5-17(23)10-16/h3-5,10-11,13,15H,6-9,12H2,1-2H3,(H,27,28)/t13-,15-
PDB

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n/an/a 226n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326314
PNG
(4-(5-chloropyridin-3-yl)-5- [(trans-4- methylcyclo...)
Show SMILES C[C@H]1CC[C@H](Cn2ccc3nc(nc(-c4cncc(Cl)c4)c23)C(O)=O)CC1
Show InChI InChI=1S/C20H21ClN4O2/c1-12-2-4-13(5-3-12)11-25-7-6-16-18(25)17(24-19(23-16)20(26)27)14-8-15(21)10-22-9-14/h6-10,12-13H,2-5,11H2,1H3,(H,26,27)/t12-,13-
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n/an/a 247n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326301
PNG
(4-{[(1R)-1- cyclobutylethyl] amino}-5-[3-fluoro-4-...)
Show SMILES C[C@@H](Nc1nc(nc2cc(-c3cccc(C)c3)n(Cc3ccc(OC(F)(F)F)c(F)c3)c12)C(O)=O)C1CCC1
Show InChI InChI=1S/C28H26F4N4O3/c1-15-5-3-8-19(11-15)22-13-21-24(25(35-26(34-21)27(37)38)33-16(2)18-6-4-7-18)36(22)14-17-9-10-23(20(29)12-17)39-28(30,31)32/h3,5,8-13,16,18H,4,6-7,14H2,1-2H3,(H,37,38)(H,33,34,35)/t16-/m1/s1
PDB

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n/an/a 267n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326312
PNG
(4-(3-chlorophenyl)-5- [(trans-4- methylcyclohexyl)...)
Show SMILES C[C@H]1CC[C@H](Cn2ccc3nc(nc(-c4cccc(Cl)c4)c23)C(O)=O)CC1
Show InChI InChI=1S/C21H22ClN3O2/c1-13-5-7-14(8-6-13)12-25-10-9-17-19(25)18(24-20(23-17)21(26)27)15-3-2-4-16(22)11-15/h2-4,9-11,13-14H,5-8,12H2,1H3,(H,26,27)/t13-,14-
PDB

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n/an/a 294n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326300
PNG
(4-{[(1R)-1- cyclobutylethyl] amino}-6-(3- methylph...)
Show SMILES C[C@@H](Nc1nc(nc2cc(-c3cccc(C)c3)n(Cc3ccc(OC(F)(F)F)cc3)c12)C(O)=O)C1CCC1
Show InChI InChI=1S/C28H27F3N4O3/c1-16-5-3-8-20(13-16)23-14-22-24(35(23)15-18-9-11-21(12-10-18)38-28(29,30)31)25(34-26(33-22)27(36)37)32-17(2)19-6-4-7-19/h3,5,8-14,17,19H,4,6-7,15H2,1-2H3,(H,36,37)(H,32,33,34)/t17-/m1/s1
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n/an/a 348n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326288
PNG
((R)-4-((1- cyclobutylethyl)amino)- 7-(2-fluoro-5- ...)
Show SMILES C[C@@H](Nc1nc(nc2c(cn(Cc3ccc(cc3)C(F)(F)F)c12)-c1cc(C)ccc1F)C(O)=O)C1CCC1
Show InChI InChI=1S/C28H26F4N4O2/c1-15-6-11-22(29)20(12-15)21-14-36(13-17-7-9-19(10-8-17)28(30,31)32)24-23(21)34-26(27(37)38)35-25(24)33-16(2)18-4-3-5-18/h6-12,14,16,18H,3-5,13H2,1-2H3,(H,37,38)(H,33,34,35)/t16-/m1/s1
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n/an/a 353n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326307
PNG
(4-{[(1R)-1- cyclobutylethyl]amino}- 5-[4- (difluor...)
Show SMILES C[C@@H](Nc1nc(nc2cc(-c3cccc(C)c3)n(Cc3ccc(cc3)C(F)F)c12)C(O)=O)C1CCC1
Show InChI InChI=1S/C28H28F2N4O2/c1-16-5-3-8-21(13-16)23-14-22-24(34(23)15-18-9-11-20(12-10-18)25(29)30)26(33-27(32-22)28(35)36)31-17(2)19-6-4-7-19/h3,5,8-14,17,19,25H,4,6-7,15H2,1-2H3,(H,35,36)(H,31,32,33)/t17-/m1/s1
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n/an/a 530n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326294
PNG
(7-(2-chloro-5- methylphenyl)-4-{[(1R)- 1- cyclobut...)
Show SMILES C[C@@H](Nc1nc(nc2c(cn(Cc3ccc(cc3)C(F)(F)F)c12)-c1cc(C)ccc1Cl)C(O)=O)C1CCC1
Show InChI InChI=1S/C28H26ClF3N4O2/c1-15-6-11-22(29)20(12-15)21-14-36(13-17-7-9-19(10-8-17)28(30,31)32)24-23(21)34-26(27(37)38)35-25(24)33-16(2)18-4-3-5-18/h6-12,14,16,18H,3-5,13H2,1-2H3,(H,37,38)(H,33,34,35)/t16-/m1/s1
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n/an/a 712n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326299
PNG
(4-{[(1R)-1- cyclobutylethyl] amino}-6-(3- methylph...)
Show SMILES C[C@@H](Nc1nc(nc2cc(-c3cccc(C)c3)n(Cc3ccc(cn3)C(F)(F)F)c12)C(O)=O)C1CCC1
Show InChI InChI=1S/C27H26F3N5O2/c1-15-5-3-8-18(11-15)22-12-21-23(35(22)14-20-10-9-19(13-31-20)27(28,29)30)24(34-25(33-21)26(36)37)32-16(2)17-6-4-7-17/h3,5,8-13,16-17H,4,6-7,14H2,1-2H3,(H,36,37)(H,32,33,34)/t16-/m1/s1
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n/an/a 844n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326303
PNG
(4-{[(1R)-1- cyclobutylethyl] amino}-5-[4- (difluor...)
Show SMILES C[C@@H](Nc1nc(nc2cc(-c3cccc(C)c3)n(Cc3ccc(OC(F)F)cc3)c12)C(O)=O)C1CCC1
Show InChI InChI=1S/C28H28F2N4O3/c1-16-5-3-8-20(13-16)23-14-22-24(34(23)15-18-9-11-21(12-10-18)37-28(29)30)25(33-26(32-22)27(35)36)31-17(2)19-6-4-7-19/h3,5,8-14,17,19,28H,4,6-7,15H2,1-2H3,(H,35,36)(H,31,32,33)/t17-/m1/s1
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n/an/a 1.78E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326302
PNG
(4-{[(1R)-1- cyclobutylethyl]amino}- 5-[2-methoxy-4...)
Show SMILES COc1cc(OC(F)(F)F)ccc1Cn1c(cc2nc(nc(N[C@H](C)C3CCC3)c12)C(O)=O)-c1cccc(C)c1
Show InChI InChI=1S/C29H29F3N4O4/c1-16-6-4-9-19(12-16)23-14-22-25(26(35-27(34-22)28(37)38)33-17(2)18-7-5-8-18)36(23)15-20-10-11-21(13-24(20)39-3)40-29(30,31)32/h4,6,9-14,17-18H,5,7-8,15H2,1-3H3,(H,37,38)(H,33,34,35)/t17-/m1/s1
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n/an/a 4.37E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


()
BDBM326305
PNG
(4-{[(1R)-1- cyclobutylethyl] amino}-5-(4- methoxyb...)
Show SMILES COc1ccc(Cn2c(cc3nc(nc(N[C@H](C)C4CCC4)c23)C(O)=O)-c2cccc(C)c2)cc1
Show InChI InChI=1S/C28H30N4O3/c1-17-6-4-9-21(14-17)24-15-23-25(32(24)16-19-10-12-22(35-3)13-11-19)26(31-27(30-23)28(33)34)29-18(2)20-7-5-8-20/h4,6,9-15,18,20H,5,7-8,16H2,1-3H3,(H,33,34)(H,29,30,31)/t18-/m1/s1
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n/an/a 6.19E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...


US Patent US9637493 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%