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Patent code US9650362

Compile Data Set for Download or QSAR
Found 20 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM98187
PNG
(US8486940, 89 | US9650362, 89)
Show SMILES O=C1OC[C@@H](N1c1ccc2nc[nH]c2c1)c1ccc(cc1)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C26H25N5O2/c32-26-31(22-10-11-23-24(16-22)28-18-27-23)25(17-33-26)19-6-8-21(9-7-19)30-14-12-29(13-15-30)20-4-2-1-3-5-20/h1-11,16,18,25H,12-15,17H2,(H,27,28)/t25-/m1/s1
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12.5n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30 C. QC activity was evaluated fluorometrical...


US Patent US9650362 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM98186
PNG
(US8486940, 73 | US9650362, 73)
Show SMILES CCCOc1ccc(cc1)[C@H]1COC(=O)N1c1ccc2nc[nH]c2c1
Show InChI InChI=1S/C19H19N3O3/c1-2-9-24-15-6-3-13(4-7-15)18-11-25-19(23)22(18)14-5-8-16-17(10-14)21-12-20-16/h3-8,10,12,18H,2,9,11H2,1H3,(H,20,21)/t18-/m1/s1
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33.6n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30 C. QC activity was evaluated fluorometrical...


US Patent US9650362 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM308046
PNG
((S)-1-(1H- benzo[d]imidazol-5-yl)-5-(4- propoxyphe...)
Show SMILES CCCOc1ccc(cc1)[C@H]1CNC(=O)N1c1ccc2[nH]cnc2c1
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37.4n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30 C. QC activity was evaluated fluorometrical...


US Patent US9650362 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM308047
PNG
((S)-1-(1H-1,3-benzodiazol- 5-yl)-5-(4- biphenyl)im...)
Show SMILES O=C1NC[C@@H](N1c1ccc2[nH]cnc2c1)c1ccc(cc1)-c1ccccc1
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40.8n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30 C. QC activity was evaluated fluorometrical...


US Patent US9650362 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM308052
PNG
((S)-2-(1H-benzo[d]imidazol- 5-yl)-3-(3,4- dimethox...)
Show SMILES COc1ccc(cc1OC)[C@@H]1N(C(=O)c2ccccc12)c1ccc2[nH]cnc2c1
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53.5n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30 C. QC activity was evaluated fluorometrical...


US Patent US9650362 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM308053
PNG
((S)-2-(1H-benzo[d]imidazol- 5-yl)-3-(4- propoxyphe...)
Show SMILES CCCOc1ccc(cc1)[C@@H]1N(C(=O)c2ccccc12)c1ccc2[nH]cnc2c1
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58.8n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30 C. QC activity was evaluated fluorometrical...


US Patent US9650362 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM308044
PNG
(1-(1H-benzo[d]imidazol-5- yl)-5-(4- propoxyphenyl)...)
Show SMILES CCCOc1ccc(cc1)C1CNC(=O)N1c1ccc2[nH]cnc2c1
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62.5n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30 C. QC activity was evaluated fluorometrical...


US Patent US9650362 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM308048
PNG
(5-(4-butoxyphenyl)-1-(H- imidazo[1,2-a]pyridin-7- ...)
Show SMILES CCCCOc1ccc(cc1)C1CNC(=O)N1c1ccn2ccnc2c1
Show InChI InChI=1S/C20H22N4O2/c1-2-3-12-26-17-6-4-15(5-7-17)18-14-22-20(25)24(18)16-8-10-23-11-9-21-19(23)13-16/h4-11,13,18H,2-3,12,14H2,1H3,(H,22,25)
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75n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30 C. QC activity was evaluated fluorometrical...


US Patent US9650362 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM98185
PNG
(US8486940, 60 | US9650362, 60)
Show SMILES O=C1NCC(N1c1ccn2ccnc2c1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C22H18N4O/c27-22-24-15-20(26(22)19-10-12-25-13-11-23-21(25)14-19)18-8-6-17(7-9-18)16-4-2-1-3-5-16/h1-14,20H,15H2,(H,24,27)
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149n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30 C. QC activity was evaluated fluorometrical...


US Patent US9650362 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM308045
PNG
((R)-1-(1H- benzo[d]imidazol-5-yl)-5-(4- propoxyphe...)
Show SMILES CCCOc1ccc(cc1)[C@@H]1CNC(=O)N1c1ccc2[nH]cnc2c1
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7.25E+3n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30 C. QC activity was evaluated fluorometrical...


US Patent US9650362 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM98187
PNG
(US8486940, 89 | US9650362, 89)
Show SMILES O=C1OC[C@@H](N1c1ccc2nc[nH]c2c1)c1ccc(cc1)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C26H25N5O2/c32-26-31(22-10-11-23-24(16-22)28-18-27-23)25(17-33-26)19-6-8-21(9-7-19)30-14-12-29(13-15-30)20-4-2-1-3-5-20/h1-11,16,18,25H,12-15,17H2,(H,27,28)/t25-/m1/s1
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n/an/a 160n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30 C. QC activity was evaluated fluorometrical...


US Patent US9650362 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM98186
PNG
(US8486940, 73 | US9650362, 73)
Show SMILES CCCOc1ccc(cc1)[C@H]1COC(=O)N1c1ccc2nc[nH]c2c1
Show InChI InChI=1S/C19H19N3O3/c1-2-9-24-15-6-3-13(4-7-15)18-11-25-19(23)22(18)14-5-8-16-17(10-14)21-12-20-16/h3-8,10,12,18H,2,9,11H2,1H3,(H,20,21)/t18-/m1/s1
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n/an/a 170n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30 C. QC activity was evaluated fluorometrical...


US Patent US9650362 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM308046
PNG
((S)-1-(1H- benzo[d]imidazol-5-yl)-5-(4- propoxyphe...)
Show SMILES CCCOc1ccc(cc1)[C@H]1CNC(=O)N1c1ccc2[nH]cnc2c1
PDB
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n/an/a 238n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30 C. QC activity was evaluated fluorometrical...


US Patent US9650362 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM308053
PNG
((S)-2-(1H-benzo[d]imidazol- 5-yl)-3-(4- propoxyphe...)
Show SMILES CCCOc1ccc(cc1)[C@@H]1N(C(=O)c2ccccc12)c1ccc2[nH]cnc2c1
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n/an/a 240n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30 C. QC activity was evaluated fluorometrical...


US Patent US9650362 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM308047
PNG
((S)-1-(1H-1,3-benzodiazol- 5-yl)-5-(4- biphenyl)im...)
Show SMILES O=C1NC[C@@H](N1c1ccc2[nH]cnc2c1)c1ccc(cc1)-c1ccccc1
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n/an/a 254n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30 C. QC activity was evaluated fluorometrical...


US Patent US9650362 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM308052
PNG
((S)-2-(1H-benzo[d]imidazol- 5-yl)-3-(3,4- dimethox...)
Show SMILES COc1ccc(cc1OC)[C@@H]1N(C(=O)c2ccccc12)c1ccc2[nH]cnc2c1
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n/an/a 297n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30 C. QC activity was evaluated fluorometrical...


US Patent US9650362 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM308048
PNG
(5-(4-butoxyphenyl)-1-(H- imidazo[1,2-a]pyridin-7- ...)
Show SMILES CCCCOc1ccc(cc1)C1CNC(=O)N1c1ccn2ccnc2c1
Show InChI InChI=1S/C20H22N4O2/c1-2-3-12-26-17-6-4-15(5-7-17)18-14-22-20(25)24(18)16-8-10-23-11-9-21-19(23)13-16/h4-11,13,18H,2-3,12,14H2,1H3,(H,22,25)
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n/an/a 397n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30 C. QC activity was evaluated fluorometrical...


US Patent US9650362 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM308044
PNG
(1-(1H-benzo[d]imidazol-5- yl)-5-(4- propoxyphenyl)...)
Show SMILES CCCOc1ccc(cc1)C1CNC(=O)N1c1ccc2[nH]cnc2c1
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n/an/a 482n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30 C. QC activity was evaluated fluorometrical...


US Patent US9650362 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM98185
PNG
(US8486940, 60 | US9650362, 60)
Show SMILES O=C1NCC(N1c1ccn2ccnc2c1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C22H18N4O/c27-22-24-15-20(26(22)19-10-12-25-13-11-23-21(25)14-19)18-8-6-17(7-9-18)16-4-2-1-3-5-16/h1-14,20H,15H2,(H,24,27)
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n/an/a 882n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30 C. QC activity was evaluated fluorometrical...


US Patent US9650362 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM308045
PNG
((R)-1-(1H- benzo[d]imidazol-5-yl)-5-(4- propoxyphe...)
Show SMILES CCCOc1ccc(cc1)[C@@H]1CNC(=O)N1c1ccc2[nH]cnc2c1
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n/an/a 3.02E+4n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30 C. QC activity was evaluated fluorometrical...


US Patent US9650362 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%