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Patent code US9656955

Compile Data Set for Download or QSAR

Found 808 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM308636
PNG
(BDBM308807 | US9656955, Example 150 | trans-N-[2-c...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@@H](NCc2ccc(cc2Cl)C(F)(F)F)[C@@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C22H21ClF4N4O2S/c1-30-12-21(29-13-30)34(32,33)31-10-18(14-3-6-17(24)7-4-14)20(11-31)28-9-15-2-5-16(8-19(15)23)22(25,26)27/h2-8,12-13,18,20,28H,9-11H2,1H3/t18-,20+/m0/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM308599
PNG
(US9656955, Example 85 | trans-4-(4-fluorophenyl)-1...)
Show SMILES Cc1cccc(N[C@@H]2CN(C[C@H]2c2ccc(F)cc2)S(=O)(=O)c2cn(C)cn2)c1
Show InChI InChI=1S/C21H23FN4O2S/c1-15-4-3-5-18(10-15)24-20-12-26(29(27,28)21-13-25(2)14-23-21)11-19(20)16-6-8-17(22)9-7-16/h3-10,13-14,19-20,24H,11-12H2,1-2H3/t19-,20+/m0/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM308808
PNG
((3R,4S)?N-[2-chloro-4-(trifluoromethyl)benzyl]-4-(...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@H](NCc2ccc(cc2Cl)C(F)(F)F)[C@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C22H21ClF4N4O2S/c1-30-12-21(29-13-30)34(32,33)31-10-18(14-3-6-17(24)7-4-14)20(11-31)28-9-15-2-5-16(8-19(15)23)22(25,26)27/h2-8,12-13,18,20,28H,9-11H2,1H3/t18-,20+/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM308884
PNG
((3R,4S)-1-[(1-methyl-1H-imidazol-4-yl)sulfonyl]-4-...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@H](NCc2ccc(cc2)C(F)(F)F)[C@H](C1)c1ccccc1
Show InChI InChI=1S/C22H23F3N4O2S/c1-28-14-21(27-15-28)32(30,31)29-12-19(17-5-3-2-4-6-17)20(13-29)26-11-16-7-9-18(10-8-16)22(23,24)25/h2-10,14-15,19-20,26H,11-13H2,1H3/t19-,20+/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM308902
PNG
((3R,4S)-N-(3-chloro-4-fluorophenyl)-1-[(1-methyl-1...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@H](Nc2ccc(F)c(Cl)c2)[C@H](C1)c1ccccc1
Show InChI InChI=1S/C20H20ClFN4O2S/c1-25-12-20(23-13-25)29(27,28)26-10-16(14-5-3-2-4-6-14)19(11-26)24-15-7-8-18(22)17(21)9-15/h2-9,12-13,16,19,24H,10-11H2,1H3/t16-,19+/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM309124
PNG
((3R,4S)vN-[4-fluoro-3-(trifluoromethoxy)phenyl]-1-...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@H](Nc2ccc(F)c(OC(F)(F)F)c2)[C@H](C1)c1ccccc1
Show InChI InChI=1S/C21H20F4N4O3S/c1-28-12-20(26-13-28)33(30,31)29-10-16(14-5-3-2-4-6-14)18(11-29)27-15-7-8-17(22)19(9-15)32-21(23,24)25/h2-9,12-13,16,18,27H,10-11H2,1H3/t16-,18+/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM309130
PNG
((3R,4S)-4-(4-fluorophenyl)-N-[4-fluoro-3-(trifluor...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@H](Nc2ccc(F)c(c2)C(F)(F)F)[C@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C21H19F5N4O2S/c1-29-11-20(27-12-29)33(31,32)30-9-16(13-2-4-14(22)5-3-13)19(10-30)28-15-6-7-18(23)17(8-15)21(24,25)26/h2-8,11-12,16,19,28H,9-10H2,1H3/t16-,19+/m1/s1
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US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM309143
PNG
((3R,4S)-4-(4-fluorophenyl)-N-hexyl-1-[(1-methyl-1H...)
Show SMILES CCCCCCN[C@H]1CN(C[C@@H]1c1ccc(F)cc1)S(=O)(=O)c1cn(C)cn1
Show InChI InChI=1S/C20H29FN4O2S/c1-3-4-5-6-11-22-19-13-25(28(26,27)20-14-24(2)15-23-20)12-18(19)16-7-9-17(21)10-8-16/h7-10,14-15,18-19,22H,3-6,11-13H2,1-2H3/t18-,19+/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM309159
PNG
(Trans-1-[(1-methyl-1H-imidazol-4-yl)sulfonyl]-4-(t...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@@H](Nc2cccc(c2)C(F)(F)F)[C@@H](C1)C1CCCCO1
Show InChI InChI=1S/C20H25F3N4O3S/c1-26-12-19(24-13-26)31(28,29)27-10-16(18-7-2-3-8-30-18)17(11-27)25-15-6-4-5-14(9-15)20(21,22)23/h4-6,9,12-13,16-18,25H,2-3,7-8,10-11H2,1H3/t16-,17-,18?/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM309163
PNG
(BDBM309164 | Trans-1-[(1-methyl-1H-imidazol-4-yl)s...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@@H](Nc2cccc(OC(F)(F)F)c2)[C@@H](C1)C1CCCCO1
Show InChI InChI=1S/C20H25F3N4O4S/c1-26-12-19(24-13-26)32(28,29)27-10-16(18-7-2-3-8-30-18)17(11-27)25-14-5-4-6-15(9-14)31-20(21,22)23/h4-6,9,12-13,16-18,25H,2-3,7-8,10-11H2,1H3/t16-,17-,18?/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM309210
PNG
((3R,4S)-N-(2,2-difluorohexyl)-4-(4-fluorophenyl)-1...)
Show SMILES CCCCC(F)(F)CN[C@H]1CN(C[C@@H]1c1ccc(F)cc1)S(=O)(=O)c1cn(C)cn1
Show InChI InChI=1S/C20H27F3N4O2S/c1-3-4-9-20(22,23)13-24-18-11-27(30(28,29)19-12-26(2)14-25-19)10-17(18)15-5-7-16(21)8-6-15/h5-8,12,14,17-18,24H,3-4,9-11,13H2,1-2H3/t17-,18+/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM309313
PNG
((3R,4S)-4-(4-fluorophenyl)-N-[4-fluoro-3-(trifluor...)
Show SMILES Cn1cc(nn1)S(=O)(=O)N1C[C@H](Nc2ccc(F)c(OC(F)(F)F)c2)[C@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C20H18F5N5O3S/c1-29-11-19(27-28-29)34(31,32)30-9-15(12-2-4-13(21)5-3-12)17(10-30)26-14-6-7-16(22)18(8-14)33-20(23,24)25/h2-8,11,15,17,26H,9-10H2,1H3/t15-,17+/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM309315
PNG
((3R,4S)-4-(4-fluorophenyl)-N-[4-fluoro-3-(trifluor...)
Show SMILES Cn1cc(nn1)S(=O)(=O)N1C[C@H](Nc2ccc(F)c(c2)C(F)(F)F)[C@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C20H18F5N5O2S/c1-29-11-19(27-28-29)33(31,32)30-9-15(12-2-4-13(21)5-3-12)18(10-30)26-14-6-7-17(22)16(8-14)20(23,24)25/h2-8,11,15,18,26H,9-10H2,1H3/t15-,18+/m1/s1
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US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM308712
PNG
(US9656955, Example 226 | trans-1-[(1-methyl-1H-imi...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@@H](Nc2cccc(OC(F)(F)F)c2)[C@@H](C1)c1ccccc1
Show InChI InChI=1S/C21H21F3N4O3S/c1-27-13-20(25-14-27)32(29,30)28-11-18(15-6-3-2-4-7-15)19(12-28)26-16-8-5-9-17(10-16)31-21(22,23)24/h2-10,13-14,18-19,26H,11-12H2,1H3/t18-,19+/m0/s1
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US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM308733
PNG
(4-{[trans-3-(4-fluorophenyl)-4-{[3-(trifluorometho...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@@H](COc2cccc(OC(F)(F)F)c2)[C@@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C22H21F4N3O4S/c1-28-12-21(27-14-28)34(30,31)29-10-16(20(11-29)15-5-7-17(23)8-6-15)13-32-18-3-2-4-19(9-18)33-22(24,25)26/h2-9,12,14,16,20H,10-11,13H2,1H3/t16-,20-/m0/s1
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US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM308748
PNG
(US9656955, Example 262 | trans-N-(4-chlorobenzyl)-...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@@H](NCc2ccc(Cl)cc2)[C@@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C21H22ClFN4O2S/c1-26-13-21(25-14-26)30(28,29)27-11-19(16-4-8-18(23)9-5-16)20(12-27)24-10-15-2-6-17(22)7-3-15/h2-9,13-14,19-20,24H,10-12H2,1H3/t19-,20+/m0/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM308753
PNG
(US9656955, Example 267 | trans-4-(4-fluorophenyl)-...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@@H](NCc2ccc(cc2)C(F)(F)F)[C@@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C22H22F4N4O2S/c1-29-13-21(28-14-29)33(31,32)30-11-19(16-4-8-18(23)9-5-16)20(12-30)27-10-15-2-6-17(7-3-15)22(24,25)26/h2-9,13-14,19-20,27H,10-12H2,1H3/t19-,20+/m0/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM308767
PNG
(BDBM308881 | US9656955, Example 281 | trans-N-[2-c...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@@H](NCc2ccc(cc2Cl)C(F)(F)F)[C@@H](C1)c1ccccc1
Show InChI InChI=1S/C22H22ClF3N4O2S/c1-29-13-21(28-14-29)33(31,32)30-11-18(15-5-3-2-4-6-15)20(12-30)27-10-16-7-8-17(9-19(16)23)22(24,25)26/h2-9,13-14,18,20,27H,10-12H2,1H3/t18-,20+/m0/s1
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Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM309095
PNG
(5-chloro-N-{(3R,4S)-4-(4-fluorophenyl)-1-[(1-methy...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@H](Nc2cc(c(Cl)cn2)C(F)(F)F)[C@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C20H18ClF4N5O2S/c1-29-10-19(27-11-29)33(31,32)30-8-14(12-2-4-13(22)5-3-12)17(9-30)28-18-6-15(20(23,24)25)16(21)7-26-18/h2-7,10-11,14,17H,8-9H2,1H3,(H,26,28)/t14-,17+/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM309199
PNG
(N-{(3R,4S)-4-(4-fluorophenyl)-1-[(1-methyl-1H-imid...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@H](Nc2cc(ncn2)-c2ccccc2)[C@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C24H23FN6O2S/c1-30-14-24(28-16-30)34(32,33)31-12-20(17-7-9-19(25)10-8-17)22(13-31)29-23-11-21(26-15-27-23)18-5-3-2-4-6-18/h2-11,14-16,20,22H,12-13H2,1H3,(H,26,27,29)/t20-,22+/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM309236
PNG
(4-chloro-N-{(3R,4S)-4-(4-fluorophenyl)-1-[(1-methy...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@H](Nc2cc(Cl)ccn2)[C@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C19H19ClFN5O2S/c1-25-11-19(23-12-25)29(27,28)26-9-16(13-2-4-15(21)5-3-13)17(10-26)24-18-8-14(20)6-7-22-18/h2-8,11-12,16-17H,9-10H2,1H3,(H,22,24)/t16-,17+/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM309286
PNG
(5-fluoro-N-{(3R,4S)-4-(4-fluorophenyl)-1-[(1-methy...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@H](Nc2cc(OCC(F)(F)F)c(F)cn2)[C@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C21H20F5N5O3S/c1-30-10-20(28-12-30)35(32,33)31-8-15(13-2-4-14(22)5-3-13)17(9-31)29-19-6-18(16(23)7-27-19)34-11-21(24,25)26/h2-7,10,12,15,17H,8-9,11H2,1H3,(H,27,29)/t15-,17+/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM309317
PNG
((3R,4S)-N-(3-chloro-4-fluorophenyl)-4-(4-fluorophe...)
Show SMILES Cn1cc(nn1)S(=O)(=O)N1C[C@H](Nc2ccc(F)c(Cl)c2)[C@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C19H18ClF2N5O2S/c1-26-11-19(24-25-26)30(28,29)27-9-15(12-2-4-13(21)5-3-12)18(10-27)23-14-6-7-17(22)16(20)8-14/h2-8,11,15,18,23H,9-10H2,1H3/t15-,18+/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM308876
PNG
(N-{(3R,4S)-4-(4-fluorophenyl)-1-[(1-methyl-1H-imid...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@H](Nc2cc(ncn2)C(F)(F)F)[C@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C19H18F4N6O2S/c1-28-9-18(26-11-28)32(30,31)29-7-14(12-2-4-13(20)5-3-12)15(8-29)27-17-6-16(19(21,22)23)24-10-25-17/h2-6,9-11,14-15H,7-8H2,1H3,(H,24,25,27)/t14-,15+/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM309049
PNG
((3R,4S)-N-[(2,5-dichlorothiophen-3-yl)methyl]-1-[(...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@H](NCc2cc(Cl)sc2Cl)[C@H](C1)c1ccccc1
Show InChI InChI=1S/C19H20Cl2N4O2S2/c1-24-11-18(23-12-24)29(26,27)25-9-15(13-5-3-2-4-6-13)16(10-25)22-8-14-7-17(20)28-19(14)21/h2-7,11-12,15-16,22H,8-10H2,1H3/t15-,16+/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM309129
PNG
((3R,4S)-4-(4-fluorophenyl)-N-[4-fluoro-3-(trifluor...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@H](Nc2ccc(F)c(OC(F)(F)F)c2)[C@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C21H19F5N4O3S/c1-29-11-20(27-12-29)34(31,32)30-9-16(13-2-4-14(22)5-3-13)18(10-30)28-15-6-7-17(23)19(8-15)33-21(24,25)26/h2-8,11-12,16,18,28H,9-10H2,1H3/t16-,18+/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM309148
PNG
((3R,4S)-1-[(1-methyl-1H-imidazol-4-yl)sulfonyl]-4-...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@H](Nc2cccc(OCC(F)(F)F)c2)[C@H](C1)c1ccccc1
Show InChI InChI=1S/C22H23F3N4O3S/c1-28-13-21(26-15-28)33(30,31)29-11-19(16-6-3-2-4-7-16)20(12-29)27-17-8-5-9-18(10-17)32-14-22(23,24)25/h2-10,13,15,19-20,27H,11-12,14H2,1H3/t19-,20+/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM309282
PNG
(5-chloro-N-{(3R,4S)-4-(4-fluorophenyl)-1-[(1-methy...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@H](Nc2cc(OCC(F)(F)F)c(Cl)cn2)[C@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C21H20ClF4N5O3S/c1-30-10-20(28-12-30)35(32,33)31-8-15(13-2-4-14(23)5-3-13)17(9-31)29-19-6-18(16(22)7-27-19)34-11-21(24,25)26/h2-7,10,12,15,17H,8-9,11H2,1H3,(H,27,29)/t15-,17+/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM308645
PNG
(US9656955, Example 159 | trans-4-(4-fluorophenyl)-...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@@H](Nc2ccc(F)c(c2)C(F)(F)F)[C@@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C21H19F5N4O2S/c1-29-11-20(27-12-29)33(31,32)30-9-16(13-2-4-14(22)5-3-13)19(10-30)28-15-6-7-18(23)17(8-15)21(24,25)26/h2-8,11-12,16,19,28H,9-10H2,1H3/t16-,19+/m0/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM308646
PNG
(BDBM308873 | US9656955, Example 160 | trans-N-(3-c...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@@H](Nc2ccc(F)c(Cl)c2)[C@@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C20H19ClF2N4O2S/c1-26-11-20(24-12-26)30(28,29)27-9-16(13-2-4-14(22)5-3-13)19(10-27)25-15-6-7-18(23)17(21)8-15/h2-8,11-12,16,19,25H,9-10H2,1H3/t16-,19+/m0/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM308706
PNG
(US9656955, Example 220 | trans-1-[(1-methyl-1H-imi...)
Show SMILES CC(C)c1cccc(N[C@@H]2CN(C[C@H]2c2ccccc2)S(=O)(=O)c2cn(C)cn2)c1
Show InChI InChI=1S/C23H28N4O2S/c1-17(2)19-10-7-11-20(12-19)25-22-14-27(13-21(22)18-8-5-4-6-9-18)30(28,29)23-15-26(3)16-24-23/h4-12,15-17,21-22,25H,13-14H2,1-3H3/t21-,22+/m0/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM308783
PNG
((3-chlorophenyl){trans-4-(4-fluorophenyl)-1-[(1-me...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@H]([C@@H](C1)c1ccc(F)cc1)C(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C21H19ClFN3O3S/c1-25-12-20(24-13-25)30(28,29)26-10-18(14-5-7-17(23)8-6-14)19(11-26)21(27)15-3-2-4-16(22)9-15/h2-9,12-13,18-19H,10-11H2,1H3/t18-,19+/m0/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM308806
PNG
(US9656955, Example 320 | trans-N-[2-chloro-4-(trif...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@@H](NCc2ccc(cc2Cl)C(F)(F)F)[C@@H](C1)c1ccccn1
Show InChI InChI=1S/C21H21ClF3N5O2S/c1-29-12-20(28-13-29)33(31,32)30-10-16(18-4-2-3-7-26-18)19(11-30)27-9-14-5-6-15(8-17(14)22)21(23,24)25/h2-8,12-13,16,19,27H,9-11H2,1H3/t16-,19+/m0/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM308838
PNG
((3R,4S)-N-(3-chloro-4-fluorophenyl)-4-(4-fluorophe...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@H](Nc2ccc(F)c(Cl)c2)[C@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C20H19ClF2N4O2S/c1-26-11-20(24-12-26)30(28,29)27-9-16(13-2-4-14(22)5-3-13)19(10-27)25-15-6-7-18(23)17(21)8-15/h2-8,11-12,16,19,25H,9-10H2,1H3/t16-,19+/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM308880
PNG
((3R,4S)-N-[2-chloro-4-(trifluoromethyl)benzyl]-1-[...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@H](NCc2ccc(cc2Cl)C(F)(F)F)[C@H](C1)c1ccccc1
Show InChI InChI=1S/C22H22ClF3N4O2S/c1-29-13-21(28-14-29)33(31,32)30-11-18(15-5-3-2-4-6-15)20(12-30)27-10-16-7-8-17(9-19(16)23)22(24,25)26/h2-9,13-14,18,20,27H,10-12H2,1H3/t18-,20+/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM309106
PNG
(Trans-N-(3-chlorobenzyl)-4-(4-fluorophenyl)-1-[(1-...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@H]([C@@H](C1)c1ccc(F)cc1)C(=O)NCc1cccc(Cl)c1
Show InChI InChI=1S/C22H22ClFN4O3S/c1-27-13-21(26-14-27)32(30,31)28-11-19(16-5-7-18(24)8-6-16)20(12-28)22(29)25-10-15-3-2-4-17(23)9-15/h2-9,13-14,19-20H,10-12H2,1H3,(H,25,29)/t19-,20+/m0/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM309109
PNG
(Trans-N-(3,4-difluorobenzyl)-4-(4-fluorophenyl)-1-...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@H]([C@@H](C1)c1ccc(F)cc1)C(=O)NCc1ccc(F)c(F)c1
Show InChI InChI=1S/C22H21F3N4O3S/c1-28-12-21(27-13-28)33(31,32)29-10-17(15-3-5-16(23)6-4-15)18(11-29)22(30)26-9-14-2-7-19(24)20(25)8-14/h2-8,12-13,17-18H,9-11H2,1H3,(H,26,30)/t17-,18+/m0/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM309129
PNG
((3R,4S)-4-(4-fluorophenyl)-N-[4-fluoro-3-(trifluor...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@H](Nc2ccc(F)c(OC(F)(F)F)c2)[C@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C21H19F5N4O3S/c1-29-11-20(27-12-29)34(31,32)30-9-16(13-2-4-14(22)5-3-13)18(10-30)28-15-6-7-17(23)19(8-15)33-21(24,25)26/h2-8,11-12,16,18,28H,9-10H2,1H3/t16-,18+/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM309202
PNG
(N-{(3R,4S)-4-(4-fluorophenyl)-1-[(1-methyl-1H-imid...)
Show SMILES Cc1ccc(cc1)-c1cc(N[C@H]2CN(C[C@@H]2c2ccc(F)cc2)S(=O)(=O)c2cn(C)cn2)ncn1
Show InChI InChI=1S/C25H25FN6O2S/c1-17-3-5-19(6-4-17)22-11-24(28-15-27-22)30-23-13-32(35(33,34)25-14-31(2)16-29-25)12-21(23)18-7-9-20(26)10-8-18/h3-11,14-16,21,23H,12-13H2,1-2H3,(H,27,28,30)/t21-,23+/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM309207
PNG
(6-(4-chlorophenyl)-N-{(3R,4S)-4-(4-fluorophenyl)-1...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@H](Nc2cc(ncn2)-c2ccc(Cl)cc2)[C@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C24H22ClFN6O2S/c1-31-13-24(29-15-31)35(33,34)32-11-20(16-4-8-19(26)9-5-16)22(12-32)30-23-10-21(27-14-28-23)17-2-6-18(25)7-3-17/h2-10,13-15,20,22H,11-12H2,1H3,(H,27,28,30)/t20-,22+/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM309253
PNG
(4-(benzyloxy)-5-fluoro-N-{(3R,4S)-1-[(1-methyl-1H-...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@H](Nc2cc(OCc3ccccc3)c(F)cn2)[C@H](C1)c1ccccc1
Show InChI InChI=1S/C26H26FN5O3S/c1-31-16-26(29-18-31)36(33,34)32-14-21(20-10-6-3-7-11-20)23(15-32)30-25-12-24(22(27)13-28-25)35-17-19-8-4-2-5-9-19/h2-13,16,18,21,23H,14-15,17H2,1H3,(H,28,30)/t21-,23+/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM309293
PNG
(Trans-N-[2-chloro-4-(trifluoromethyl)benzyl]-4-(3-...)
Show SMILES Cn1cc(nn1)S(=O)(=O)N1C[C@@H](NCc2ccc(cc2Cl)C(F)(F)F)[C@@H](C1)c1ncccc1F
Show InChI InChI=1S/C20H19ClF4N6O2S/c1-30-11-18(28-29-30)34(32,33)31-9-14(19-16(22)3-2-6-26-19)17(10-31)27-8-12-4-5-13(7-15(12)21)20(23,24)25/h2-7,11,14,17,27H,8-10H2,1H3/t14-,17-/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM308602
PNG
(BDBM308812 | US9656955, Example 88 | trans-4-(4-fl...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@@H](Nc2cccc(c2)C(F)(F)F)[C@@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C21H20F4N4O2S/c1-28-12-20(26-13-28)32(30,31)29-10-18(14-5-7-16(22)8-6-14)19(11-29)27-17-4-2-3-15(9-17)21(23,24)25/h2-9,12-13,18-19,27H,10-11H2,1H3/t18-,19+/m0/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM308608
PNG
(BDBM308811 | US9656955, Example 94 | trans-N-(3-ch...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@@H](Nc2cccc(Cl)c2)[C@@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C20H20ClFN4O2S/c1-25-12-20(23-13-25)29(27,28)26-10-18(14-5-7-16(22)8-6-14)19(11-26)24-17-4-2-3-15(21)9-17/h2-9,12-13,18-19,24H,10-11H2,1H3/t18-,19+/m0/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM309314
PNG
((3R,4S)-4-(4-fluorophenyl)-1-[(1-methyl-1H-1,2,3-t...)
Show SMILES Cn1cc(nn1)S(=O)(=O)N1C[C@H](Nc2cccc(c2)C(F)(F)F)[C@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C20H19F4N5O2S/c1-28-12-19(26-27-28)32(30,31)29-10-17(13-5-7-15(21)8-6-13)18(11-29)25-16-4-2-3-14(9-16)20(22,23)24/h2-9,12,17-18,25H,10-11H2,1H3/t17-,18+/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM308815
PNG
((3R,4S)-4-(4-fluorophenyl)-1-[(1-methyl-1H-imidazo...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@H](Nc2cccc(OC(F)(F)F)c2)[C@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C21H20F4N4O3S/c1-28-12-20(26-13-28)33(30,31)29-10-18(14-5-7-15(22)8-6-14)19(11-29)27-16-3-2-4-17(9-16)32-21(23,24)25/h2-9,12-13,18-19,27H,10-11H2,1H3/t18-,19+/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM309120
PNG
(Trans-N-(3-chloro-4-fluorobenzyl)-4-(4-fluoropheny...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@H]([C@@H](C1)c1ccc(F)cc1)C(=O)NCc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C22H21ClF2N4O3S/c1-28-12-21(27-13-28)33(31,32)29-10-17(15-3-5-16(24)6-4-15)18(11-29)22(30)26-9-14-2-7-20(25)19(23)8-14/h2-8,12-13,17-18H,9-11H2,1H3,(H,26,30)/t17-,18+/m0/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM309206
PNG
(6-(3-chlorophenyl)-N-{(3R,4S)-4-(4-fluorophenyl)-1...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@H](Nc2cc(ncn2)-c2cccc(Cl)c2)[C@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C24H22ClFN6O2S/c1-31-13-24(29-15-31)35(33,34)32-11-20(16-5-7-19(26)8-6-16)22(12-32)30-23-10-21(27-14-28-23)17-3-2-4-18(25)9-17/h2-10,13-15,20,22H,11-12H2,1H3,(H,27,28,30)/t20-,22+/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM309221
PNG
((3R,4S)-4-(4-fluorophenyl)-1-[(1-methyl-1H-imidazo...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@H](Nc2cccc(OCC(F)(F)F)c2)[C@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C22H22F4N4O3S/c1-29-12-21(27-14-29)34(31,32)30-10-19(15-5-7-16(23)8-6-15)20(11-30)28-17-3-2-4-18(9-17)33-13-22(24,25)26/h2-9,12,14,19-20,28H,10-11,13H2,1H3/t19-,20+/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens)
BDBM309222
PNG
((3R,4S)-4-(4-fluorophenyl)-N-[4-fluoro-3-(pyridin-...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@H](Nc2ccc(F)c(c2)-c2cccnc2)[C@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C25H23F2N5O2S/c1-31-15-25(29-16-31)35(33,34)32-13-22(17-4-6-19(26)7-5-17)24(14-32)30-20-8-9-23(27)21(11-20)18-3-2-10-28-12-18/h2-12,15-16,22,24,30H,13-14H2,1H3/t22-,24+/m1/s1
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AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)

More data for this
Ligand-Target Pair
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