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Patent code US9656991

Compile Data Set for Download or QSAR
Found 121 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM50299853
PNG
(1-(3,4-Dimethoxyphenyl)-3-(3-(5-methyl-1H-imidazol...)
Show SMILES COc1ccc(NC(=S)NCCCn2cncc2C)cc1OC
Show InChI InChI=1S/C16H22N4O2S/c1-12-10-17-11-20(12)8-4-7-18-16(23)19-13-5-6-14(21-2)15(9-13)22-3/h5-6,9-11H,4,7-8H2,1-3H3,(H2,18,19,23)
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6n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309890
PNG
(1-(3,4,5- trimethoxyphenyl)-3- (3-(5-methyl-1H- im...)
Show SMILES COc1cc(NC(=S)NCCCn2cncc2C)cc(OC)c1OC
Show InChI InChI=1S/C17H24N4O3S/c1-12-10-18-11-21(12)7-5-6-19-17(25)20-13-8-14(22-2)16(24-4)15(9-13)23-3/h8-11H,5-7H2,1-4H3,(H2,19,20,25)
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15n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309891
PNG
(1-(3,5- dimethoxyphenyl)-3- (3-(5-methyl-1H- imida...)
Show SMILES COc1cc(NC(=S)NCCCn2cncc2C)cc(OC)c1
Show InChI InChI=1S/C16H22N4O2S/c1-12-10-17-11-20(12)6-4-5-18-16(23)19-13-7-14(21-2)9-15(8-13)22-3/h7-11H,4-6H2,1-3H3,(H2,18,19,23)
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24n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309919
PNG
(1-(4- (benzyloxy)phenyl)- 3-(3-(5-methyl-1H- imida...)
Show SMILES Cc1cncn1CCCNC(=S)Nc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C21H24N4OS/c1-17-14-22-16-25(17)13-5-12-23-21(27)24-19-8-10-20(11-9-19)26-15-18-6-3-2-4-7-18/h2-4,6-11,14,16H,5,12-13,15H2,1H3,(H2,23,24,27)
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25n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309917
PNG
(1-(3,4- dimethoxyphenyl)-3- (4-(5-methyl-1H- imida...)
Show SMILES COc1ccc(NC(=S)NCCCCn2cncc2C)cc1OC
Show InChI InChI=1S/C17H24N4O2S/c1-13-11-18-12-21(13)9-5-4-8-19-17(24)20-14-6-7-15(22-2)16(10-14)23-3/h6-7,10-12H,4-5,8-9H2,1-3H3,(H2,19,20,24)
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27n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309892
PNG
(1-(2,4- dimethoxyphenyl)-3- (3-(5-methyl-1H- imida...)
Show SMILES COc1ccc(NC(=S)NCCCn2cncc2C)c(OC)c1
Show InChI InChI=1S/C16H22N4O2S/c1-12-10-17-11-20(12)8-4-7-18-16(23)19-14-6-5-13(21-2)9-15(14)22-3/h5-6,9-11H,4,7-8H2,1-3H3,(H2,18,19,23)
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28n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309935
PNG
(1-(3,4- dimethoxybenzyl)-3- (1H- benzo[d]imidazol-...)
Show SMILES COc1ccc(CNC(=S)Nc2ccc3[nH]cnc3c2)cc1OC
Show InChI InChI=1S/C17H18N4O2S/c1-22-15-6-3-11(7-16(15)23-2)9-18-17(24)21-12-4-5-13-14(8-12)20-10-19-13/h3-8,10H,9H2,1-2H3,(H,19,20)(H2,18,21,24)
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29n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309889
PNG
(1-(4-ethoxyphenyl)- 3-(3-(5-methyl-1H- imidazol-1-...)
Show SMILES CCOc1ccc(NC(=S)NCCCn2cncc2C)cc1
Show InChI InChI=1S/C16H22N4OS/c1-3-21-15-7-5-14(6-8-15)19-16(22)18-9-4-10-20-12-17-11-13(20)2/h5-8,11-12H,3-4,9-10H2,1-2H3,(H2,18,19,22)
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32n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309893
PNG
(1-(4- methoxyphenyl)-3- (3-(5-methyl-1H- imidazol-...)
Show SMILES COc1ccc(NC(=S)NCCCn2cncc2C)cc1
Show InChI InChI=1S/C15H20N4OS/c1-12-10-16-11-19(12)9-3-8-17-15(21)18-13-4-6-14(20-2)7-5-13/h4-7,10-11H,3,8-9H2,1-2H3,(H2,17,18,21)
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32n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309888
PNG
(1-(3-(5-methyl-1H- imidazol-1- yl)propyl)-3-(4- (o...)
Show SMILES Cc1cncn1CCCNC(=S)Nc1ccc(cc1)-c1cnco1
Show InChI InChI=1S/C17H19N5OS/c1-13-9-18-11-22(13)8-2-7-20-17(24)21-15-5-3-14(4-6-15)16-10-19-12-23-16/h3-6,9-12H,2,7-8H2,1H3,(H2,20,21,24)
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35n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309918
PNG
(1-mesityl-3-(3-(5- methyl-1H-imidazol- 1-yl)propyl...)
Show SMILES Cc1cncn1CCCNC(=S)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C17H24N4S/c1-12-8-13(2)16(14(3)9-12)20-17(22)19-6-5-7-21-11-18-10-15(21)4/h8-11H,5-7H2,1-4H3,(H2,19,20,22)
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41n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM50299849
PNG
(1-(3,4-Dimethoxyphenyl)-3-(3-(4-methyl-1H-imidazol...)
Show SMILES COc1ccc(NC(=S)NCCCn2cnc(C)c2)cc1OC
Show InChI InChI=1S/C16H22N4O2S/c1-12-10-20(11-18-12)8-4-7-17-16(23)19-13-5-6-14(21-2)15(9-13)22-3/h5-6,9-11H,4,7-8H2,1-3H3,(H2,17,19,23)
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60n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309942
PNG
(1-(2,4- dimethoxybenzyl)-3- (1H- benzo[d]imidazol-...)
Show SMILES COc1ccc(CNC(=S)Nc2ccc3[nH]cnc3c2)c(OC)c1
Show InChI InChI=1S/C17H18N4O2S/c1-22-13-5-3-11(16(8-13)23-2)9-18-17(24)21-12-4-6-14-15(7-12)20-10-19-14/h3-8,10H,9H2,1-2H3,(H,19,20)(H2,18,21,24)
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108n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309943
PNG
(1-(4-hydroxy-3- methoxybenzyl)-3- (1H- benzo[d]imi...)
Show SMILES COc1cc(CNC(=S)Nc2ccc3[nH]cnc3c2)ccc1O
Show InChI InChI=1S/C16H16N4O2S/c1-22-15-6-10(2-5-14(15)21)8-17-16(23)20-11-3-4-12-13(7-11)19-9-18-12/h2-7,9,21H,8H2,1H3,(H,18,19)(H2,17,20,23)
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110n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309949
PNG
(1-(3-chloro-4- methoxybenzyl)-3- (1H- benzo[d]imid...)
Show SMILES COc1ccc(CNC(=S)Nc2ccc3[nH]cnc3c2)cc1Cl
Show InChI InChI=1S/C16H15ClN4OS/c1-22-15-5-2-10(6-12(15)17)8-18-16(23)21-11-3-4-13-14(7-11)20-9-19-13/h2-7,9H,8H2,1H3,(H,19,20)(H2,18,21,23)
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120n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309937
PNG
(1-(1H-benzo[d]- imidazol-5-yl)-3- ((R)-1-(4- metho...)
Show SMILES COc1ccc(cc1)C(C)NC(=S)Nc1ccc2[nH]cnc2c1
Show InChI InChI=1S/C17H18N4OS/c1-11(12-3-6-14(22-2)7-4-12)20-17(23)21-13-5-8-15-16(9-13)19-10-18-15/h3-11H,1-2H3,(H,18,19)(H2,20,21,23)
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166n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309938
PNG
(1-(3,4,5-trimethoxy- benzyl)-3-(1H- benzo[d]imidaz...)
Show SMILES COc1cc(CNC(=S)Nc2ccc3[nH]cnc3c2)cc(OC)c1OC
Show InChI InChI=1S/C18H20N4O3S/c1-23-15-6-11(7-16(24-2)17(15)25-3)9-19-18(26)22-12-4-5-13-14(8-12)21-10-20-13/h4-8,10H,9H2,1-3H3,(H,20,21)(H2,19,22,26)
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166n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309924
PNG
(1-(3,4,5- trimethoxyphenyl)-3- (3-(4-methyl-1H- im...)
Show SMILES COc1cc(NC(=S)NCCCn2cnc(C)c2)cc(OC)c1OC
Show InChI InChI=1S/C17H24N4O3S/c1-12-10-21(11-19-12)7-5-6-18-17(25)20-13-8-14(22-2)16(24-4)15(9-13)23-3/h8-11H,5-7H2,1-4H3,(H2,18,20,25)
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258n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309898
PNG
(1-(4- methoxybenzyl)-3- (1H- benzo[d]imidazol-5- y...)
Show SMILES COc1ccc(CNC(=S)Nc2ccc3[nH]cnc3c2)cc1
Show InChI InChI=1S/C16H16N4OS/c1-21-13-5-2-11(3-6-13)9-17-16(22)20-12-4-7-14-15(8-12)19-10-18-14/h2-8,10H,9H2,1H3,(H,18,19)(H2,17,20,22)
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264n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309921
PNG
(1-(4- (benzyloxy)phenyl)- 3-(3-(4-methyl-1H- imida...)
Show SMILES Cc1cn(CCCNC(=S)Nc2ccc(OCc3ccccc3)cc2)cn1
Show InChI InChI=1S/C21H24N4OS/c1-17-14-25(16-23-17)13-5-12-22-21(27)24-19-8-10-20(11-9-19)26-15-18-6-3-2-4-7-18/h2-4,6-11,14,16H,5,12-13,15H2,1H3,(H2,22,24,27)
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272n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309944
PNG
(1-(3-hydroxy-4- methoxybenzyl)-3- (1H- benzo[d]imi...)
Show SMILES COc1ccc(CNC(=S)Nc2ccc3[nH]cnc3c2)cc1O
Show InChI InChI=1S/C16H16N4O2S/c1-22-15-5-2-10(6-14(15)21)8-17-16(23)20-11-3-4-12-13(7-11)19-9-18-12/h2-7,9,21H,8H2,1H3,(H,18,19)(H2,17,20,23)
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290n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309922
PNG
(1-mesityl-3-(3-(4- methyl-1H-imidazol- 1-yl)propyl...)
Show SMILES Cc1cn(CCCNC(=S)Nc2c(C)cc(C)cc2C)cn1
Show InChI InChI=1S/C17H24N4S/c1-12-8-13(2)16(14(3)9-12)20-17(22)18-6-5-7-21-10-15(4)19-11-21/h8-11H,5-7H2,1-4H3,(H2,18,20,22)
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412n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309939
PNG
(1-(3- methoxybenzyl)-3- (1H-benzo[d]- imidazol-5- ...)
Show SMILES COc1cccc(CNC(=S)Nc2ccc3[nH]cnc3c2)c1
Show InChI InChI=1S/C16H16N4OS/c1-21-13-4-2-3-11(7-13)9-17-16(22)20-12-5-6-14-15(8-12)19-10-18-14/h2-8,10H,9H2,1H3,(H,18,19)(H2,17,20,22)
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426n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309925
PNG
(1-(3,5- dimethoxyphenyl)-3- (3-(4-methyl-1H- imida...)
Show SMILES COc1cc(NC(=S)NCCCn2cnc(C)c2)cc(OC)c1
Show InChI InChI=1S/C16H22N4O2S/c1-12-10-20(11-18-12)6-4-5-17-16(23)19-13-7-14(21-2)9-15(8-13)22-3/h7-11H,4-6H2,1-3H3,(H2,17,19,23)
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496n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309926
PNG
(1-(2,4- dimethoxyphenyl)-3- (3-(4-methyl-1H- imida...)
Show SMILES COc1ccc(NC(=S)NCCCn2cnc(C)c2)c(OC)c1
Show InChI InChI=1S/C16H22N4O2S/c1-12-10-20(11-18-12)8-4-7-17-16(23)19-14-6-5-13(21-2)9-15(14)22-3/h5-6,9-11H,4,7-8H2,1-3H3,(H2,17,19,23)
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513n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309895
PNG
(1- ((benzo[d][1,3]dioxol- 5-yl)methyl)-3-(1H- benz...)
Show SMILES S=C(NCc1ccc2OCOc2c1)Nc1ccc2[nH]cnc2c1
Show InChI InChI=1S/C16H14N4O2S/c23-16(20-11-2-3-12-13(6-11)19-8-18-12)17-7-10-1-4-14-15(5-10)22-9-21-14/h1-6,8H,7,9H2,(H,18,19)(H2,17,20,23)
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544n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309930
PNG
(1-(2,4- dichlorobenzyl)-3- (1H-benzo[d]- imidazol-...)
Show SMILES Clc1ccc(CNC(=S)Nc2ccc3[nH]cnc3c2)c(Cl)c1
Show InChI InChI=1S/C15H12Cl2N4S/c16-10-2-1-9(12(17)5-10)7-18-15(22)21-11-3-4-13-14(6-11)20-8-19-13/h1-6,8H,7H2,(H,19,20)(H2,18,21,22)
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699n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309928
PNG
(1-(3,4- dichlorobenzyl)-3- (1H-benzo[d]- imidazol-...)
Show SMILES Clc1ccc(CNC(=S)Nc2ccc3[nH]cnc3c2)cc1Cl
Show InChI InChI=1S/C15H12Cl2N4S/c16-11-3-1-9(5-12(11)17)7-18-15(22)21-10-2-4-13-14(6-10)20-8-19-13/h1-6,8H,7H2,(H,19,20)(H2,18,21,22)
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722n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309916
PNG
(1-(1H- benzo[d]imidazol- 5/6-yl)-3-(3,4- dimethoxy...)
Show SMILES COc1ccc(NC(=S)Nc2ccc3[nH]cnc3c2)cc1OC
Show InChI InChI=1S/C16H16N4O2S/c1-21-14-6-4-11(8-15(14)22-2)20-16(23)19-10-3-5-12-13(7-10)18-9-17-12/h3-9H,1-2H3,(H,17,18)(H2,19,20,23)
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780n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309940
PNG
(1-(2- methoxybenzyl)-3- (1H-benzo[d]- imidazol-5- ...)
Show SMILES COc1ccccc1CNC(=S)Nc1ccc2[nH]cnc2c1
Show InChI InChI=1S/C16H16N4OS/c1-21-15-5-3-2-4-11(15)9-17-16(22)20-12-6-7-13-14(8-12)19-10-18-13/h2-8,10H,9H2,1H3,(H,18,19)(H2,17,20,22)
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855n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309929
PNG
(1-(2-chlorobenzyl)- 3-(1H- benzo[d]imidazol-5- yl)...)
Show SMILES Clc1ccccc1CNC(=S)Nc1ccc2[nH]cnc2c1
Show InChI InChI=1S/C15H13ClN4S/c16-12-4-2-1-3-10(12)8-17-15(21)20-11-5-6-13-14(7-11)19-9-18-13/h1-7,9H,8H2,(H,18,19)(H2,17,20,21)
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1.03E+3n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309912
PNG
(1-(1H- benzo[d]imidazol-5- yl)-3-(4- methoxyphenyl...)
Show SMILES COc1ccc(NC(=S)Nc2ccc3[nH]cnc3c2)cc1
Show InChI InChI=1S/C15H14N4OS/c1-20-12-5-2-10(3-6-12)18-15(21)19-11-4-7-13-14(8-11)17-9-16-13/h2-9H,1H3,(H,16,17)(H2,18,19,21)
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1.09E+3n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309899
PNG
(1-(4-methyl)-3-(1H- benzo[d]imidazol-5- tl)thioure...)
Show SMILES Cc1ccc(CNC(=S)Nc2ccc3[nH]cnc3c2)cc1
Show InChI InChI=1S/C16H16N4S/c1-11-2-4-12(5-3-11)9-17-16(21)20-13-6-7-14-15(8-13)19-10-18-14/h2-8,10H,9H2,1H3,(H,18,19)(H2,17,20,21)
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1.14E+3n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309900
PNG
(1-(4-chlorobenzyl)- 3-(1H- benzo[d]imidazol-5- yl)...)
Show SMILES Clc1ccc(CNC(=S)Nc2ccc3[nH]cnc3c2)cc1
Show InChI InChI=1S/C15H13ClN4S/c16-11-3-1-10(2-4-11)8-17-15(21)20-12-5-6-13-14(7-12)19-9-18-13/h1-7,9H,8H2,(H,18,19)(H2,17,20,21)
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1.18E+3n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309936
PNG
(1-(1H-benzo[d]- imidazol-5-yl)-3- ((S)-1-(4- metho...)
Show SMILES COc1ccc(cc1)[C@H](C)NC(=S)Nc1ccc2[nH]cnc2c1
Show InChI InChI=1S/C17H18N4OS/c1-11(12-3-6-14(22-2)7-4-12)20-17(23)21-13-5-8-15-16(9-13)19-10-18-15/h3-11H,1-2H3,(H,18,19)(H2,20,21,23)/t11-/m0/s1
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1.21E+3n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309901
PNG
(1-(4-fluorobenzyl)-3- (1H- benzo[d]imidazol-5- yl)...)
Show SMILES Fc1ccc(CNC(=S)Nc2ccc3[nH]cnc3c2)cc1
Show InChI InChI=1S/C15H13FN4S/c16-11-3-1-10(2-4-11)8-17-15(21)20-12-5-6-13-14(7-12)19-9-18-13/h1-7,9H,8H2,(H,18,19)(H2,17,20,21)
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1.37E+3n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309934
PNG
(1-(3,4- difluorobenzyl)-3- (1H-benzo[d]- imidazol-...)
Show SMILES Fc1ccc(CNC(=S)Nc2ccc3[nH]cnc3c2)cc1F
Show InChI InChI=1S/C15H12F2N4S/c16-11-3-1-9(5-12(11)17)7-18-15(22)21-10-2-4-13-14(6-10)20-8-19-13/h1-6,8H,7H2,(H,19,20)(H2,18,21,22)
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1.50E+3n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309931
PNG
(1-(2-(trifluoro- methoxy-)benzyl)-3- (1H-benzo[d]-...)
Show SMILES FC(F)(F)Oc1ccccc1CNC(=S)Nc1ccc2[nH]cnc2c1
Show InChI InChI=1S/C16H13F3N4OS/c17-16(18,19)24-14-4-2-1-3-10(14)8-20-15(25)23-11-5-6-12-13(7-11)22-9-21-12/h1-7,9H,8H2,(H,21,22)(H2,20,23,25)
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1.62E+3n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309911
PNG
(1- (benzo[c][1,2,5]thia- diazol-4-yl)-3-(1H- benzo...)
Show SMILES S=C(Nc1ccc2[nH]cnc2c1)Nc1cccc2nsnc12
Show InChI InChI=1S/C14H10N6S2/c21-14(17-8-4-5-9-12(6-8)16-7-15-9)18-10-2-1-3-11-13(10)20-22-19-11/h1-7H,(H,15,16)(H2,17,18,21)
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1.86E+3n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309915
PNG
(1-(1H- benzo[d]imidazol-5- yl)-3-(3,5- dimethoxyph...)
Show SMILES COc1cc(NC(=S)Nc2ccc3[nH]cnc3c2)cc(OC)c1
Show InChI InChI=1S/C16H16N4O2S/c1-21-12-5-11(6-13(8-12)22-2)20-16(23)19-10-3-4-14-15(7-10)18-9-17-14/h3-9H,1-2H3,(H,17,18)(H2,19,20,23)
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2.04E+3n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309933
PNG
(1-(1H-benzo[d]- imidazol-5-yl)-3-(1- phenylethyl)t...)
Show SMILES CC(NC(=S)Nc1ccc2[nH]cnc2c1)c1ccccc1
Show InChI InChI=1S/C16H16N4S/c1-11(12-5-3-2-4-6-12)19-16(21)20-13-7-8-14-15(9-13)18-10-17-14/h2-11H,1H3,(H,17,18)(H2,19,20,21)
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2.05E+3n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309896
PNG
(1-(1H- benzo[d]imidazol-5- yl)-3-benzylthiourea | ...)
Show SMILES S=C(NCc1ccccc1)Nc1ccc2[nH]cnc2c1
Show InChI InChI=1S/C15H14N4S/c20-15(16-9-11-4-2-1-3-5-11)19-12-6-7-13-14(8-12)18-10-17-13/h1-8,10H,9H2,(H,17,18)(H2,16,19,20)
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2.10E+3n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309914
PNG
(1-(1H- benzo[d]imidazol-5- yl)-3-(2,4- dimethoxyph...)
Show SMILES COc1ccc(NC(=S)Nc2ccc3[nH]cnc3c2)c(OC)c1
Show InChI InChI=1S/C16H16N4O2S/c1-21-11-4-6-13(15(8-11)22-2)20-16(23)19-10-3-5-12-14(7-10)18-9-17-12/h3-9H,1-2H3,(H,17,18)(H2,19,20,23)
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2.19E+3n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309903
PNG
(1-(1H- benzo[d]imidazol-5- yl)-3- ((tetrahydrofura...)
Show SMILES S=C(NCC1CCCO1)Nc1ccc2[nH]cnc2c1
Show InChI InChI=1S/C13H16N4OS/c19-13(14-7-10-2-1-5-18-10)17-9-3-4-11-12(6-9)16-8-15-11/h3-4,6,8,10H,1-2,5,7H2,(H,15,16)(H2,14,17,19)
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2.62E+3n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309902
PNG
(1-(1H- benzo[d]imidazol-5- yl)-3-((furan-2- yl)met...)
Show SMILES S=C(NCc1ccco1)Nc1ccc2[nH]cnc2c1
Show InChI InChI=1S/C13H12N4OS/c19-13(14-7-10-2-1-5-18-10)17-9-3-4-11-12(6-9)16-8-15-11/h1-6,8H,7H2,(H,15,16)(H2,14,17,19)
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2.72E+3n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309906
PNG
(1-(1H- benzo[d]imidazol-5- yl)-3-(3- methoxyphenyl...)
Show SMILES COc1cccc(NC(=S)Nc2ccc3[nH]cnc3c2)c1
Show InChI InChI=1S/C15H14N4OS/c1-20-12-4-2-3-10(7-12)18-15(21)19-11-5-6-13-14(8-11)17-9-16-13/h2-9H,1H3,(H,16,17)(H2,18,19,21)
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3.20E+3n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309905
PNG
(1- (benzo[d][1,3]dioxol- 5-yl)-3-(1H- benzo[d]imid...)
Show SMILES S=C(Nc1ccc2OCOc2c1)Nc1ccc2[nH]cnc2c1
Show InChI InChI=1S/C15H12N4O2S/c22-15(18-9-1-3-11-12(5-9)17-7-16-11)19-10-2-4-13-14(6-10)21-8-20-13/h1-7H,8H2,(H,16,17)(H2,18,19,22)
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4.08E+3n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309897
PNG
(1-(1H- benzo[d]imidazol-5- yl)-3- phenethylthioure...)
Show SMILES S=C(NCCc1ccccc1)Nc1ccc2[nH]cnc2c1
Show InChI InChI=1S/C16H16N4S/c21-16(17-9-8-12-4-2-1-3-5-12)20-13-6-7-14-15(10-13)19-11-18-14/h1-7,10-11H,8-9H2,(H,18,19)(H2,17,20,21)
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4.48E+3n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309910
PNG
(1- (benzo[c][1,2,5]thia- diazol-5-yl)-3-(1H- benzo...)
Show SMILES S=C(Nc1ccc2[nH]cnc2c1)Nc1ccc2nsnc2c1
Show InChI InChI=1S/C14H10N6S2/c21-14(17-8-1-3-10-12(5-8)16-7-15-10)18-9-2-4-11-13(6-9)20-22-19-11/h1-7H,(H,15,16)(H2,17,18,21)
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4.93E+3n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309913
PNG
(1-(1H- benzo[d]imidazol-5- yl)-3-(naphthalen-1- yl...)
Show SMILES S=C(Nc1ccc2[nH]cnc2c1)Nc1cccc2ccccc12
Show InChI InChI=1S/C18H14N4S/c23-18(21-13-8-9-16-17(10-13)20-11-19-16)22-15-7-3-5-12-4-1-2-6-14(12)15/h1-11H,(H,19,20)(H2,21,22,23)
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5.00E+3n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309909
PNG
(1-(1H- benzo[d]imidazol-5- yl)-3-(4- bromophenyl)t...)
Show SMILES Brc1ccc(NC(=S)Nc2ccc3[nH]cnc3c2)cc1
Show InChI InChI=1S/C14H11BrN4S/c15-9-1-3-10(4-2-9)18-14(20)19-11-5-6-12-13(7-11)17-8-16-12/h1-8H,(H,16,17)(H2,18,19,20)
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5.17E+3n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309932
PNG
(1-(1H-benzo[d]- imidazol-5-yl)-3- ((pyridin-2- yl)...)
Show SMILES S=C(NCc1ccccn1)Nc1ccc2[nH]cnc2c1
Show InChI InChI=1S/C14H13N5S/c20-14(16-8-11-3-1-2-6-15-11)19-10-4-5-12-13(7-10)18-9-17-12/h1-7,9H,8H2,(H,17,18)(H2,16,19,20)
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5.37E+3n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309904
PNG
(1-(1H- benzo[d]imidazol-5- yl)-3-p-tolylthiourea |...)
Show SMILES Cc1ccc(NC(=S)Nc2ccc3[nH]cnc3c2)cc1
Show InChI InChI=1S/C15H14N4S/c1-10-2-4-11(5-3-10)18-15(20)19-12-6-7-13-14(8-12)17-9-16-13/h2-9H,1H3,(H,16,17)(H2,18,19,20)
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5.98E+3n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309908
PNG
(1-(1H- benzo[d]imidazol-5- yl)-3-(4- fluorophenyl)...)
Show SMILES Fc1ccc(NC(=S)Nc2ccc3[nH]cnc3c2)cc1
Show InChI InChI=1S/C14H11FN4S/c15-9-1-3-10(4-2-9)18-14(20)19-11-5-6-12-13(7-11)17-8-16-12/h1-8H,(H,16,17)(H2,18,19,20)
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8.33E+3n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309890
PNG
(1-(3,4,5- trimethoxyphenyl)-3- (3-(5-methyl-1H- im...)
Show SMILES COc1cc(NC(=S)NCCCn2cncc2C)cc(OC)c1OC
Show InChI InChI=1S/C17H24N4O3S/c1-12-10-18-11-21(12)7-5-6-19-17(25)20-13-8-14(22-2)16(24-4)15(9-13)23-3/h8-11H,5-7H2,1-4H3,(H2,19,20,25)
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n/an/a 134n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309919
PNG
(1-(4- (benzyloxy)phenyl)- 3-(3-(5-methyl-1H- imida...)
Show SMILES Cc1cncn1CCCNC(=S)Nc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C21H24N4OS/c1-17-14-22-16-25(17)13-5-12-23-21(27)24-19-8-10-20(11-9-19)26-15-18-6-3-2-4-7-18/h2-4,6-11,14,16H,5,12-13,15H2,1H3,(H2,23,24,27)
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n/an/a 184n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309892
PNG
(1-(2,4- dimethoxyphenyl)-3- (3-(5-methyl-1H- imida...)
Show SMILES COc1ccc(NC(=S)NCCCn2cncc2C)c(OC)c1
Show InChI InChI=1S/C16H22N4O2S/c1-12-10-17-11-20(12)8-4-7-18-16(23)19-14-6-5-13(21-2)9-15(14)22-3/h5-6,9-11H,4,7-8H2,1-3H3,(H2,18,19,23)
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n/an/a 185n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309935
PNG
(1-(3,4- dimethoxybenzyl)-3- (1H- benzo[d]imidazol-...)
Show SMILES COc1ccc(CNC(=S)Nc2ccc3[nH]cnc3c2)cc1OC
Show InChI InChI=1S/C17H18N4O2S/c1-22-15-6-3-11(7-16(15)23-2)9-18-17(24)21-12-4-5-13-14(8-12)20-10-19-13/h3-8,10H,9H2,1-2H3,(H,19,20)(H2,18,21,24)
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n/an/a 218n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309918
PNG
(1-mesityl-3-(3-(5- methyl-1H-imidazol- 1-yl)propyl...)
Show SMILES Cc1cncn1CCCNC(=S)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C17H24N4S/c1-12-8-13(2)16(14(3)9-12)20-17(22)19-6-5-7-21-11-18-10-15(21)4/h8-11H,5-7H2,1-4H3,(H2,19,20,22)
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n/an/a 220n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309893
PNG
(1-(4- methoxyphenyl)-3- (3-(5-methyl-1H- imidazol-...)
Show SMILES COc1ccc(NC(=S)NCCCn2cncc2C)cc1
Show InChI InChI=1S/C15H20N4OS/c1-12-10-16-11-19(12)9-3-8-17-15(21)18-13-4-6-14(20-2)7-5-13/h4-7,10-11H,3,8-9H2,1-2H3,(H2,17,18,21)
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n/an/a 272n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309891
PNG
(1-(3,5- dimethoxyphenyl)-3- (3-(5-methyl-1H- imida...)
Show SMILES COc1cc(NC(=S)NCCCn2cncc2C)cc(OC)c1
Show InChI InChI=1S/C16H22N4O2S/c1-12-10-17-11-20(12)6-4-5-18-16(23)19-13-7-14(21-2)9-15(8-13)22-3/h7-11H,4-6H2,1-3H3,(H2,18,19,23)
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n/an/a 307n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309888
PNG
(1-(3-(5-methyl-1H- imidazol-1- yl)propyl)-3-(4- (o...)
Show SMILES Cc1cncn1CCCNC(=S)Nc1ccc(cc1)-c1cnco1
Show InChI InChI=1S/C17H19N5OS/c1-13-9-18-11-22(13)8-2-7-20-17(24)21-15-5-3-14(4-6-15)16-10-19-12-23-16/h3-6,9-12H,2,7-8H2,1H3,(H2,20,21,24)
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n/an/a 357n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309889
PNG
(1-(4-ethoxyphenyl)- 3-(3-(5-methyl-1H- imidazol-1-...)
Show SMILES CCOc1ccc(NC(=S)NCCCn2cncc2C)cc1
Show InChI InChI=1S/C16H22N4OS/c1-3-21-15-7-5-14(6-8-15)19-16(22)18-9-4-10-20-12-17-11-13(20)2/h5-8,11-12H,3-4,9-10H2,1-2H3,(H2,18,19,22)
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PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309917
PNG
(1-(3,4- dimethoxyphenyl)-3- (4-(5-methyl-1H- imida...)
Show SMILES COc1ccc(NC(=S)NCCCCn2cncc2C)cc1OC
Show InChI InChI=1S/C17H24N4O2S/c1-13-11-18-12-21(13)9-5-4-8-19-17(24)20-14-6-7-15(22-2)16(10-14)23-3/h6-7,10-12H,4-5,8-9H2,1-3H3,(H2,19,20,24)
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n/an/a 650n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309942
PNG
(1-(2,4- dimethoxybenzyl)-3- (1H- benzo[d]imidazol-...)
Show SMILES COc1ccc(CNC(=S)Nc2ccc3[nH]cnc3c2)c(OC)c1
Show InChI InChI=1S/C17H18N4O2S/c1-22-13-5-3-11(16(8-13)23-2)9-18-17(24)21-12-4-6-14-15(7-12)20-10-19-14/h3-8,10H,9H2,1-2H3,(H,19,20)(H2,18,21,24)
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PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309943
PNG
(1-(4-hydroxy-3- methoxybenzyl)-3- (1H- benzo[d]imi...)
Show SMILES COc1cc(CNC(=S)Nc2ccc3[nH]cnc3c2)ccc1O
Show InChI InChI=1S/C16H16N4O2S/c1-22-15-6-10(2-5-14(15)21)8-17-16(23)20-11-3-4-12-13(7-11)19-9-18-12/h2-7,9,21H,8H2,1H3,(H,18,19)(H2,17,20,23)
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n/an/a 920n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309938
PNG
(1-(3,4,5-trimethoxy- benzyl)-3-(1H- benzo[d]imidaz...)
Show SMILES COc1cc(CNC(=S)Nc2ccc3[nH]cnc3c2)cc(OC)c1OC
Show InChI InChI=1S/C18H20N4O3S/c1-23-15-6-11(7-16(24-2)17(15)25-3)9-19-18(26)22-12-4-5-13-14(8-12)21-10-20-13/h4-8,10H,9H2,1-3H3,(H,20,21)(H2,19,22,26)
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n/an/a 1.10E+3n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309937
PNG
(1-(1H-benzo[d]- imidazol-5-yl)-3- ((R)-1-(4- metho...)
Show SMILES COc1ccc(cc1)C(C)NC(=S)Nc1ccc2[nH]cnc2c1
Show InChI InChI=1S/C17H18N4OS/c1-11(12-3-6-14(22-2)7-4-12)20-17(23)21-13-5-8-15-16(9-13)19-10-18-15/h3-11H,1-2H3,(H,18,19)(H2,20,21,23)
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n/an/a 1.15E+3n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309949
PNG
(1-(3-chloro-4- methoxybenzyl)-3- (1H- benzo[d]imid...)
Show SMILES COc1ccc(CNC(=S)Nc2ccc3[nH]cnc3c2)cc1Cl
Show InChI InChI=1S/C16H15ClN4OS/c1-22-15-5-2-10(6-12(15)17)8-18-16(23)21-11-3-4-13-14(7-11)20-9-19-13/h2-7,9H,8H2,1H3,(H,19,20)(H2,18,21,23)
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n/an/a 1.21E+3n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309921
PNG
(1-(4- (benzyloxy)phenyl)- 3-(3-(4-methyl-1H- imida...)
Show SMILES Cc1cn(CCCNC(=S)Nc2ccc(OCc3ccccc3)cc2)cn1
Show InChI InChI=1S/C21H24N4OS/c1-17-14-25(16-23-17)13-5-12-22-21(27)24-19-8-10-20(11-9-19)26-15-18-6-3-2-4-7-18/h2-4,6-11,14,16H,5,12-13,15H2,1H3,(H2,22,24,27)
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n/an/a 1.99E+3n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309944
PNG
(1-(3-hydroxy-4- methoxybenzyl)-3- (1H- benzo[d]imi...)
Show SMILES COc1ccc(CNC(=S)Nc2ccc3[nH]cnc3c2)cc1O
Show InChI InChI=1S/C16H16N4O2S/c1-22-15-5-2-10(6-14(15)21)8-17-16(23)20-11-3-4-12-13(7-11)19-9-18-12/h2-7,9,21H,8H2,1H3,(H,18,19)(H2,17,20,23)
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n/an/a 2.63E+3n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309898
PNG
(1-(4- methoxybenzyl)-3- (1H- benzo[d]imidazol-5- y...)
Show SMILES COc1ccc(CNC(=S)Nc2ccc3[nH]cnc3c2)cc1
Show InChI InChI=1S/C16H16N4OS/c1-21-13-5-2-11(3-6-13)9-17-16(22)20-12-4-7-14-15(8-12)19-10-18-14/h2-8,10H,9H2,1H3,(H,18,19)(H2,17,20,22)
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n/an/a 2.66E+3n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309924
PNG
(1-(3,4,5- trimethoxyphenyl)-3- (3-(4-methyl-1H- im...)
Show SMILES COc1cc(NC(=S)NCCCn2cnc(C)c2)cc(OC)c1OC
Show InChI InChI=1S/C17H24N4O3S/c1-12-10-21(11-19-12)7-5-6-18-17(25)20-13-8-14(22-2)16(24-4)15(9-13)23-3/h8-11H,5-7H2,1-4H3,(H2,18,20,25)
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n/an/a 2.88E+3n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309895
PNG
(1- ((benzo[d][1,3]dioxol- 5-yl)methyl)-3-(1H- benz...)
Show SMILES S=C(NCc1ccc2OCOc2c1)Nc1ccc2[nH]cnc2c1
Show InChI InChI=1S/C16H14N4O2S/c23-16(20-11-2-3-12-13(6-11)19-8-18-12)17-7-10-1-4-14-15(5-10)22-9-21-14/h1-6,8H,7,9H2,(H,18,19)(H2,17,20,23)
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n/an/a 3.24E+3n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309939
PNG
(1-(3- methoxybenzyl)-3- (1H-benzo[d]- imidazol-5- ...)
Show SMILES COc1cccc(CNC(=S)Nc2ccc3[nH]cnc3c2)c1
Show InChI InChI=1S/C16H16N4OS/c1-21-13-4-2-3-11(7-13)9-17-16(22)20-12-5-6-14-15(8-12)19-10-18-14/h2-8,10H,9H2,1H3,(H,18,19)(H2,17,20,22)
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n/an/a 3.33E+3n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309925
PNG
(1-(3,5- dimethoxyphenyl)-3- (3-(4-methyl-1H- imida...)
Show SMILES COc1cc(NC(=S)NCCCn2cnc(C)c2)cc(OC)c1
Show InChI InChI=1S/C16H22N4O2S/c1-12-10-20(11-18-12)6-4-5-17-16(23)19-13-7-14(21-2)9-15(8-13)22-3/h7-11H,4-6H2,1-3H3,(H2,17,19,23)
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n/an/a 4.10E+3n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309922
PNG
(1-mesityl-3-(3-(4- methyl-1H-imidazol- 1-yl)propyl...)
Show SMILES Cc1cn(CCCNC(=S)Nc2c(C)cc(C)cc2C)cn1
Show InChI InChI=1S/C17H24N4S/c1-12-8-13(2)16(14(3)9-12)20-17(22)18-6-5-7-21-10-15(4)19-11-21/h8-11H,5-7H2,1-4H3,(H2,18,20,22)
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n/an/a 4.22E+3n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309926
PNG
(1-(2,4- dimethoxyphenyl)-3- (3-(4-methyl-1H- imida...)
Show SMILES COc1ccc(NC(=S)NCCCn2cnc(C)c2)c(OC)c1
Show InChI InChI=1S/C16H22N4O2S/c1-12-10-20(11-18-12)8-4-7-17-16(23)19-14-6-5-13(21-2)9-15(14)22-3/h5-6,9-11H,4,7-8H2,1-3H3,(H2,17,19,23)
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n/an/a 4.61E+3n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309920
PNG
(1-(4- methoxyphenyl)-3- (3-(4-methyl-1H- imidazol-...)
Show SMILES COc1ccc(NC(=S)NCCCn2cnc(C)c2)cc1
Show InChI InChI=1S/C15H20N4OS/c1-12-10-19(11-17-12)9-3-8-16-15(21)18-13-4-6-14(20-2)7-5-13/h4-7,10-11H,3,8-9H2,1-2H3,(H2,16,18,21)
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n/an/a 5.30E+3n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309923
PNG
(1-(4-ethoxyphenyl)- 3-(3-(4-methyl-1H- imidazol-1-...)
Show SMILES CCOc1ccc(NC(=S)NCCCn2cnc(C)c2)cc1
Show InChI InChI=1S/C16H22N4OS/c1-3-21-15-7-5-14(6-8-15)19-16(22)17-9-4-10-20-11-13(2)18-12-20/h5-8,11-12H,3-4,9-10H2,1-2H3,(H2,17,19,22)
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n/an/a 5.47E+3n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309946
PNG
(1-(1H-benzo[d]- imidazol-5-yl)-3- ((R)-1- phenylpr...)
Show SMILES CC[C@@H](NC(=S)Nc1ccc2[nH]cnc2c1)c1ccccc1
Show InChI InChI=1S/C17H18N4S/c1-2-14(12-6-4-3-5-7-12)21-17(22)20-13-8-9-15-16(10-13)19-11-18-15/h3-11,14H,2H2,1H3,(H,18,19)(H2,20,21,22)/t14-/m1/s1
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n/an/a 5.56E+3n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309930
PNG
(1-(2,4- dichlorobenzyl)-3- (1H-benzo[d]- imidazol-...)
Show SMILES Clc1ccc(CNC(=S)Nc2ccc3[nH]cnc3c2)c(Cl)c1
Show InChI InChI=1S/C15H12Cl2N4S/c16-10-2-1-9(12(17)5-10)7-18-15(22)21-11-3-4-13-14(6-11)20-8-19-13/h1-6,8H,7H2,(H,19,20)(H2,18,21,22)
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n/an/a 5.68E+3n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309927
PNG
(1-(3-(4-methyl-1H- imidazol-1- yl)propyl)-3-(4- (o...)
Show SMILES Cc1cn(CCCNC(=S)Nc2ccc(cc2)-c2cnco2)cn1
Show InChI InChI=1S/C17H19N5OS/c1-13-10-22(11-20-13)8-2-7-19-17(24)21-15-5-3-14(4-6-15)16-9-18-12-23-16/h3-6,9-12H,2,7-8H2,1H3,(H2,19,21,24)
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n/an/a 6.08E+3n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309928
PNG
(1-(3,4- dichlorobenzyl)-3- (1H-benzo[d]- imidazol-...)
Show SMILES Clc1ccc(CNC(=S)Nc2ccc3[nH]cnc3c2)cc1Cl
Show InChI InChI=1S/C15H12Cl2N4S/c16-11-3-1-9(5-12(11)17)7-18-15(22)21-10-2-4-13-14(6-10)20-8-19-13/h1-6,8H,7H2,(H,19,20)(H2,18,21,22)
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n/an/a 6.15E+3n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309940
PNG
(1-(2- methoxybenzyl)-3- (1H-benzo[d]- imidazol-5- ...)
Show SMILES COc1ccccc1CNC(=S)Nc1ccc2[nH]cnc2c1
Show InChI InChI=1S/C16H16N4OS/c1-21-15-5-3-2-4-11(15)9-17-16(22)20-12-6-7-13-14(8-12)19-10-18-13/h2-8,10H,9H2,1H3,(H,18,19)(H2,17,20,22)
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n/an/a 6.77E+3n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309945
PNG
(1-(3,4- methoxybenzyl)-3- (1H- benzo[d]imidazol-5-...)
Show SMILES Oc1ccc(CNC(=S)Nc2ccc3[nH]cnc3c2)cc1O
Show InChI InChI=1S/C15H14N4O2S/c20-13-4-1-9(5-14(13)21)7-16-15(22)19-10-2-3-11-12(6-10)18-8-17-11/h1-6,8,20-21H,7H2,(H,17,18)(H2,16,19,22)
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n/an/a 7.53E+3n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309929
PNG
(1-(2-chlorobenzyl)- 3-(1H- benzo[d]imidazol-5- yl)...)
Show SMILES Clc1ccccc1CNC(=S)Nc1ccc2[nH]cnc2c1
Show InChI InChI=1S/C15H13ClN4S/c16-12-4-2-1-3-10(12)8-17-15(21)20-11-5-6-13-14(7-11)19-9-18-13/h1-7,9H,8H2,(H,18,19)(H2,17,20,21)
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n/an/a 7.60E+3n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309941
PNG
(1-(2,5- dimethoxybenzyl)-3- (1H- benzo[d]imidazol-...)
Show SMILES COc1ccc(OC)c(CNC(=S)Nc2ccc3[nH]cnc3c2)c1
Show InChI InChI=1S/C17H18N4O2S/c1-22-13-4-6-16(23-2)11(7-13)9-18-17(24)21-12-3-5-14-15(8-12)20-10-19-14/h3-8,10H,9H2,1-2H3,(H,19,20)(H2,18,21,24)
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n/an/a 7.66E+3n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309899
PNG
(1-(4-methyl)-3-(1H- benzo[d]imidazol-5- tl)thioure...)
Show SMILES Cc1ccc(CNC(=S)Nc2ccc3[nH]cnc3c2)cc1
Show InChI InChI=1S/C16H16N4S/c1-11-2-4-12(5-3-11)9-17-16(21)20-13-6-7-14-15(8-13)19-10-18-14/h2-8,10H,9H2,1H3,(H,18,19)(H2,17,20,21)
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n/an/a 7.94E+3n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309936
PNG
(1-(1H-benzo[d]- imidazol-5-yl)-3- ((S)-1-(4- metho...)
Show SMILES COc1ccc(cc1)[C@H](C)NC(=S)Nc1ccc2[nH]cnc2c1
Show InChI InChI=1S/C17H18N4OS/c1-11(12-3-6-14(22-2)7-4-12)20-17(23)21-13-5-8-15-16(9-13)19-10-18-15/h3-11H,1-2H3,(H,18,19)(H2,20,21,23)/t11-/m0/s1
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n/an/a 8.32E+3n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309900
PNG
(1-(4-chlorobenzyl)- 3-(1H- benzo[d]imidazol-5- yl)...)
Show SMILES Clc1ccc(CNC(=S)Nc2ccc3[nH]cnc3c2)cc1
Show InChI InChI=1S/C15H13ClN4S/c16-11-3-1-10(2-4-11)8-17-15(21)20-12-5-6-13-14(7-12)19-9-18-13/h1-7,9H,8H2,(H,18,19)(H2,17,20,21)
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n/an/a 9.86E+3n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309901
PNG
(1-(4-fluorobenzyl)-3- (1H- benzo[d]imidazol-5- yl)...)
Show SMILES Fc1ccc(CNC(=S)Nc2ccc3[nH]cnc3c2)cc1
Show InChI InChI=1S/C15H13FN4S/c16-11-3-1-10(2-4-11)8-17-15(21)20-12-5-6-13-14(7-12)19-9-18-13/h1-7,9H,8H2,(H,18,19)(H2,17,20,21)
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US Patent
n/an/a 1.09E+4n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309948
PNG
(1-(2,3-dimethoxy- benzyl)-3-(1H- benzo[d]imidazol-...)
Show SMILES COc1cccc(CNC(=S)Nc2ccc3[nH]cnc3c2)c1OC
Show InChI InChI=1S/C17H18N4O2S/c1-22-15-5-3-4-11(16(15)23-2)9-18-17(24)21-12-6-7-13-14(8-12)20-10-19-13/h3-8,10H,9H2,1-2H3,(H,19,20)(H2,18,21,24)
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n/an/a 1.11E+4n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309912
PNG
(1-(1H- benzo[d]imidazol-5- yl)-3-(4- methoxyphenyl...)
Show SMILES COc1ccc(NC(=S)Nc2ccc3[nH]cnc3c2)cc1
Show InChI InChI=1S/C15H14N4OS/c1-20-12-5-2-10(3-6-12)18-15(21)19-11-4-7-13-14(8-11)17-9-16-13/h2-9H,1H3,(H,16,17)(H2,18,19,21)
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US Patent
n/an/a 1.13E+4n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309934
PNG
(1-(3,4- difluorobenzyl)-3- (1H-benzo[d]- imidazol-...)
Show SMILES Fc1ccc(CNC(=S)Nc2ccc3[nH]cnc3c2)cc1F
Show InChI InChI=1S/C15H12F2N4S/c16-11-3-1-9(5-12(11)17)7-18-15(22)21-10-2-4-13-14(6-10)20-8-19-13/h1-6,8H,7H2,(H,19,20)(H2,18,21,22)
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US Patent
n/an/a 1.15E+4n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309931
PNG
(1-(2-(trifluoro- methoxy-)benzyl)-3- (1H-benzo[d]-...)
Show SMILES FC(F)(F)Oc1ccccc1CNC(=S)Nc1ccc2[nH]cnc2c1
Show InChI InChI=1S/C16H13F3N4OS/c17-16(18,19)24-14-4-2-1-3-10(14)8-20-15(25)23-11-5-6-12-13(7-11)22-9-21-12/h1-7,9H,8H2,(H,21,22)(H2,20,23,25)
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n/an/a 1.40E+4n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309896
PNG
(1-(1H- benzo[d]imidazol-5- yl)-3-benzylthiourea | ...)
Show SMILES S=C(NCc1ccccc1)Nc1ccc2[nH]cnc2c1
Show InChI InChI=1S/C15H14N4S/c20-15(16-9-11-4-2-1-3-5-11)19-12-6-7-13-14(8-12)18-10-17-13/h1-8,10H,9H2,(H,17,18)(H2,16,19,20)
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n/an/a 1.62E+4n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309911
PNG
(1- (benzo[c][1,2,5]thia- diazol-4-yl)-3-(1H- benzo...)
Show SMILES S=C(Nc1ccc2[nH]cnc2c1)Nc1cccc2nsnc12
Show InChI InChI=1S/C14H10N6S2/c21-14(17-8-4-5-9-12(6-8)16-7-15-9)18-10-2-1-3-11-13(10)20-22-19-11/h1-7H,(H,15,16)(H2,17,18,21)
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US Patent
n/an/a 1.69E+4n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309902
PNG
(1-(1H- benzo[d]imidazol-5- yl)-3-((furan-2- yl)met...)
Show SMILES S=C(NCc1ccco1)Nc1ccc2[nH]cnc2c1
Show InChI InChI=1S/C13H12N4OS/c19-13(14-7-10-2-1-5-18-10)17-9-3-4-11-12(6-9)16-8-15-11/h1-6,8H,7H2,(H,15,16)(H2,14,17,19)
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n/an/a 1.70E+4n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309914
PNG
(1-(1H- benzo[d]imidazol-5- yl)-3-(2,4- dimethoxyph...)
Show SMILES COc1ccc(NC(=S)Nc2ccc3[nH]cnc3c2)c(OC)c1
Show InChI InChI=1S/C16H16N4O2S/c1-21-11-4-6-13(15(8-11)22-2)20-16(23)19-10-3-5-12-14(7-10)18-9-17-12/h3-9H,1-2H3,(H,17,18)(H2,19,20,23)
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n/an/a 1.88E+4n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309933
PNG
(1-(1H-benzo[d]- imidazol-5-yl)-3-(1- phenylethyl)t...)
Show SMILES CC(NC(=S)Nc1ccc2[nH]cnc2c1)c1ccccc1
Show InChI InChI=1S/C16H16N4S/c1-11(12-5-3-2-4-6-12)19-16(21)20-13-7-8-14-15(9-13)18-10-17-14/h2-11H,1H3,(H,17,18)(H2,19,20,21)
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n/an/a 1.88E+4n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309915
PNG
(1-(1H- benzo[d]imidazol-5- yl)-3-(3,5- dimethoxyph...)
Show SMILES COc1cc(NC(=S)Nc2ccc3[nH]cnc3c2)cc(OC)c1
Show InChI InChI=1S/C16H16N4O2S/c1-21-12-5-11(6-13(8-12)22-2)20-16(23)19-10-3-4-14-15(7-10)18-9-17-14/h3-9H,1-2H3,(H,17,18)(H2,19,20,23)
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n/an/a 1.93E+4n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309906
PNG
(1-(1H- benzo[d]imidazol-5- yl)-3-(3- methoxyphenyl...)
Show SMILES COc1cccc(NC(=S)Nc2ccc3[nH]cnc3c2)c1
Show InChI InChI=1S/C15H14N4OS/c1-20-12-4-2-3-10(7-12)18-15(21)19-11-5-6-13-14(8-11)17-9-16-13/h2-9H,1H3,(H,16,17)(H2,18,19,21)
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n/an/a 2.00E+4n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309947
PNG
(1-(1H-benzo[d]- imidazol-5-yl)-3- ((S)-1- phenylpr...)
Show SMILES CC[C@H](NC(=S)Nc1ccc2[nH]cnc2c1)c1ccccc1
Show InChI InChI=1S/C17H18N4S/c1-2-14(12-6-4-3-5-7-12)21-17(22)20-13-8-9-15-16(10-13)19-11-18-15/h3-11,14H,2H2,1H3,(H,18,19)(H2,20,21,22)/t14-/m0/s1
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n/an/a 2.03E+4n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309950
PNG
(1-(1H- benzo[d]imidazol-5- yl)-3-(1,2- diphenyleth...)
Show SMILES S=C(NC(Cc1ccccc1)c1ccccc1)Nc1ccc2[nH]cnc2c1
Show InChI InChI=1S/C22H20N4S/c27-22(25-18-11-12-19-21(14-18)24-15-23-19)26-20(17-9-5-2-6-10-17)13-16-7-3-1-4-8-16/h1-12,14-15,20H,13H2,(H,23,24)(H2,25,26,27)
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n/an/a 2.59E+4n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309897
PNG
(1-(1H- benzo[d]imidazol-5- yl)-3- phenethylthioure...)
Show SMILES S=C(NCCc1ccccc1)Nc1ccc2[nH]cnc2c1
Show InChI InChI=1S/C16H16N4S/c21-16(17-9-8-12-4-2-1-3-5-12)20-13-6-7-14-15(10-13)19-11-18-14/h1-7,10-11H,8-9H2,(H,18,19)(H2,17,20,21)
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n/an/a 2.99E+4n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309905
PNG
(1- (benzo[d][1,3]dioxol- 5-yl)-3-(1H- benzo[d]imid...)
Show SMILES S=C(Nc1ccc2OCOc2c1)Nc1ccc2[nH]cnc2c1
Show InChI InChI=1S/C15H12N4O2S/c22-15(18-9-1-3-11-12(5-9)17-7-16-11)19-10-2-4-13-14(6-10)21-8-20-13/h1-7H,8H2,(H,16,17)(H2,18,19,22)
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n/an/a 3.08E+4n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309903
PNG
(1-(1H- benzo[d]imidazol-5- yl)-3- ((tetrahydrofura...)
Show SMILES S=C(NCC1CCCO1)Nc1ccc2[nH]cnc2c1
Show InChI InChI=1S/C13H16N4OS/c19-13(14-7-10-2-1-5-18-10)17-9-3-4-11-12(6-9)16-8-15-11/h3-4,6,8,10H,1-2,5,7H2,(H,15,16)(H2,14,17,19)
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n/an/a 3.18E+4n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309910
PNG
(1- (benzo[c][1,2,5]thia- diazol-5-yl)-3-(1H- benzo...)
Show SMILES S=C(Nc1ccc2[nH]cnc2c1)Nc1ccc2nsnc2c1
Show InChI InChI=1S/C14H10N6S2/c21-14(17-8-1-3-10-12(5-8)16-7-15-10)18-9-2-4-11-13(6-9)20-22-19-11/h1-7H,(H,15,16)(H2,17,18,21)
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n/an/a 3.24E+4n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309913
PNG
(1-(1H- benzo[d]imidazol-5- yl)-3-(naphthalen-1- yl...)
Show SMILES S=C(Nc1ccc2[nH]cnc2c1)Nc1cccc2ccccc12
Show InChI InChI=1S/C18H14N4S/c23-18(21-13-8-9-16-17(10-13)20-11-19-16)22-15-7-3-5-12-4-1-2-6-14(12)15/h1-11H,(H,19,20)(H2,21,22,23)
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n/an/a 3.29E+4n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309904
PNG
(1-(1H- benzo[d]imidazol-5- yl)-3-p-tolylthiourea |...)
Show SMILES Cc1ccc(NC(=S)Nc2ccc3[nH]cnc3c2)cc1
Show InChI InChI=1S/C15H14N4S/c1-10-2-4-11(5-3-10)18-15(20)19-12-6-7-13-14(8-12)17-9-16-13/h2-9H,1H3,(H,16,17)(H2,18,19,20)
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n/an/a 3.91E+4n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309932
PNG
(1-(1H-benzo[d]- imidazol-5-yl)-3- ((pyridin-2- yl)...)
Show SMILES S=C(NCc1ccccn1)Nc1ccc2[nH]cnc2c1
Show InChI InChI=1S/C14H13N5S/c20-14(16-8-11-3-1-2-6-15-11)19-10-4-5-12-13(7-10)18-9-17-12/h1-7,9H,8H2,(H,17,18)(H2,16,19,20)
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n/an/a 4.69E+4n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309907
PNG
(1-(1H- benzo[d]imidazol-5- yl)-3-(4- iodophenyl)th...)
Show SMILES Ic1ccc(NC(=S)Nc2ccc3[nH]cnc3c2)cc1
Show InChI InChI=1S/C14H11IN4S/c15-9-1-3-10(4-2-9)18-14(20)19-11-5-6-12-13(7-11)17-8-16-12/h1-8H,(H,16,17)(H2,18,19,20)
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n/an/a 5.75E+4n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309909
PNG
(1-(1H- benzo[d]imidazol-5- yl)-3-(4- bromophenyl)t...)
Show SMILES Brc1ccc(NC(=S)Nc2ccc3[nH]cnc3c2)cc1
Show InChI InChI=1S/C14H11BrN4S/c15-9-1-3-10(4-2-9)18-14(20)19-11-5-6-12-13(7-11)17-8-16-12/h1-8H,(H,16,17)(H2,18,19,20)
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UniChem
US Patent
n/an/a 5.93E+4n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309908
PNG
(1-(1H- benzo[d]imidazol-5- yl)-3-(4- fluorophenyl)...)
Show SMILES Fc1ccc(NC(=S)Nc2ccc3[nH]cnc3c2)cc1
Show InChI InChI=1S/C14H11FN4S/c15-9-1-3-10(4-2-9)18-14(20)19-11-5-6-12-13(7-11)17-8-16-12/h1-8H,(H,16,17)(H2,18,19,20)
PDB
MMDB

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PC sid
UniChem
US Patent
n/an/a 6.17E+4n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309952
PNG
(N-(1H-benzo[d]- imidazol-5-yl)-2-(4- fluoro-phenyl...)
Show SMILES Fc1ccc(cc1)C1CCCN1C(=S)Nc1ccc2[nH]cnc2c1
Show InChI InChI=1S/C18H17FN4S/c19-13-5-3-12(4-6-13)17-2-1-9-23(17)18(24)22-14-7-8-15-16(10-14)21-11-20-15/h3-8,10-11,17H,1-2,9H2,(H,20,21)(H,22,24)
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UniChem
US Patent
n/an/a 1.28E+5n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309954
PNG
(N-(1H-benzo[d]- imidazol-5-yl)- morpholine-4- carb...)
Show SMILES S=C(Nc1ccc2[nH]cnc2c1)N1CCOCC1
Show InChI InChI=1S/C12H14N4OS/c18-12(16-3-5-17-6-4-16)15-9-1-2-10-11(7-9)14-8-13-10/h1-2,7-8H,3-6H2,(H,13,14)(H,15,18)
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UniChem
US Patent
n/an/a 1.69E+5n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309955
PNG
(N-(1H-benzo[d]- imidazol-5-yl)- piperidine-1- carb...)
Show SMILES S=C(Nc1ccc2[nH]cnc2c1)N1CCCCC1
Show InChI InChI=1S/C13H16N4S/c18-13(17-6-2-1-3-7-17)16-10-4-5-11-12(8-10)15-9-14-11/h4-5,8-9H,1-3,6-7H2,(H,14,15)(H,16,18)
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UniChem
US Patent
n/an/a 1.72E+5n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309953
PNG
(N-(1H-benzo[d]- imidazol-5-yl)- pyrrolidine-1-carb...)
Show SMILES S=C(Nc1ccc2[nH]cnc2c1)N1CCCC1
Show InChI InChI=1S/C12H14N4S/c17-12(16-5-1-2-6-16)15-9-3-4-10-11(7-9)14-8-13-10/h3-4,7-8H,1-2,5-6H2,(H,13,14)(H,15,17)
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US Patent
n/an/a 2.58E+5n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309956
PNG
(N-(1H- benzo[d]imidazol-5- yl)-4-(4- fluorophenyl)...)
Show SMILES Fc1ccc(cc1)N1CCN(CC1)C(=S)Nc1ccc2[nH]cnc2c1
Show InChI InChI=1S/C18H18FN5S/c19-13-1-4-15(5-2-13)23-7-9-24(10-8-23)18(25)22-14-3-6-16-17(11-14)21-12-20-16/h1-6,11-12H,7-10H2,(H,20,21)(H,22,25)
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UniChem
US Patent
n/an/a 3.23E+5n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM309951
PNG
(1-(4-fluorobenzyl)-3- (1H- benzo[d]imidazol-5- yl)...)
Show SMILES CN(Cc1ccc(F)cc1)C(=S)Nc1ccc2[nH]cnc2c1
Show InChI InChI=1S/C16H15FN4S/c1-21(9-11-2-4-12(17)5-3-11)16(22)20-13-6-7-14-15(8-13)19-10-18-14/h2-8,10H,9H2,1H3,(H,18,19)(H,20,22)
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UniChem
US Patent
n/an/a 4.04E+5n/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...


US Patent US9656991 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%