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Patent code US9657007

Compile Data Set for Download or QSAR
Found 36 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM259449
PNG
(US9512114, 8 | US9657007, Example 8)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C24H20ClN7O2/c1-13(29-22-20(21(26)27-12-28-22)23-30-14(2)31-34-23)18-11-15-7-6-10-17(25)19(15)24(33)32(18)16-8-4-3-5-9-16/h3-13H,1-2H3,(H3,26,27,28,29)/t13-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white 384 ...


US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM259444
PNG
(US9512114, 3 | US9657007, Example 3)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C25H22ClN7O2/c1-3-18(31-23-21(22(27)28-13-29-23)24-30-14(2)32-35-24)19-12-15-8-7-11-17(26)20(15)25(34)33(19)16-9-5-4-6-10-16/h4-13,18H,3H2,1-2H3,(H3,27,28,29,31)/t18-/m0/s1
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white 384 ...


US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM259443
PNG
(US9512114, 2 | US9657007, Example 2)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1cc2cccc(C)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C26H25N7O2/c1-4-19(31-24-22(23(27)28-14-29-24)25-30-16(3)32-35-25)20-13-17-10-8-9-15(2)21(17)26(34)33(20)18-11-6-5-7-12-18/h5-14,19H,4H2,1-3H3,(H3,27,28,29,31)/t19-/m0/s1
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white 384 ...


US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM259457
PNG
(US9512114, 22 | US9657007, Example 22)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(CC)no1)c1cc2cccc(Cl)c2c(=O)n1C1CC1
Show InChI InChI=1S/C23H24ClN7O2/c1-3-15(28-21-19(20(25)26-11-27-21)22-29-17(4-2)30-33-22)16-10-12-6-5-7-14(24)18(12)23(32)31(16)13-8-9-13/h5-7,10-11,13,15H,3-4,8-9H2,1-2H3,(H3,25,26,27,28)/t15-/m0/s1
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white 384 ...


US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM259458
PNG
(US9512114, 23 | US9657007, Example 23)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1cc2cccc(Cl)c2c(=O)n1-c1cccc(F)c1
Show InChI InChI=1S/C24H19ClFN7O2/c1-12(30-22-20(21(27)28-11-29-22)23-31-13(2)32-35-23)18-9-14-5-3-8-17(25)19(14)24(34)33(18)16-7-4-6-15(26)10-16/h3-12H,1-2H3,(H3,27,28,29,30)/t12-/m0/s1
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white 384 ...


US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM259459
PNG
(US9512114, 24 | US9657007, Example 24)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1cc2cccc(Cl)c2c(=O)n1C1CC1
Show InChI InChI=1S/C21H20ClN7O2/c1-10(26-19-17(18(23)24-9-25-19)20-27-11(2)28-31-20)15-8-12-4-3-5-14(22)16(12)21(30)29(15)13-6-7-13/h3-5,8-10,13H,6-7H2,1-2H3,(H3,23,24,25,26)/t10-/m0/s1
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white 384 ...


US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM259448
PNG
(US9512114, 7 | US9657007, Example 7)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1cc2cccc(Cl)c2c(=O)n1C1CC1
Show InChI InChI=1S/C22H22ClN7O2/c1-3-15(28-20-18(19(24)25-10-26-20)21-27-11(2)29-32-21)16-9-12-5-4-6-14(23)17(12)22(31)30(16)13-7-8-13/h4-6,9-10,13,15H,3,7-8H2,1-2H3,(H3,24,25,26,28)/t15-/m0/s1
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white 384 ...


US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM259450
PNG
(US9512114, 9 | US9657007, Example 9)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C24H20ClN7O2/c1-13(29-22-20(21(26)27-12-28-22)23-31-30-14(2)34-23)18-11-15-7-6-10-17(25)19(15)24(33)32(18)16-8-4-3-5-9-16/h3-13H,1-2H3,(H3,26,27,28,29)/t13-/m0/s1
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white 384 ...


US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM259442
PNG
(US9512114, 1 | US9657007, Example 1)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1cc2cccc(F)c2c(=O)n1C1CC1
Show InChI InChI=1S/C22H22FN7O2/c1-3-15(28-20-18(19(24)25-10-26-20)21-27-11(2)29-32-21)16-9-12-5-4-6-14(23)17(12)22(31)30(16)13-7-8-13/h4-6,9-10,13,15H,3,7-8H2,1-2H3,(H3,24,25,26,28)/t15-/m0/s1
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white 384 ...


US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM259446
PNG
(US9512114, 5 | US9657007, Example 5)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C25H22ClN7O2/c1-3-18(30-23-21(22(27)28-13-29-23)24-32-31-14(2)35-24)19-12-15-8-7-11-17(26)20(15)25(34)33(19)16-9-5-4-6-10-16/h4-13,18H,3H2,1-2H3,(H3,27,28,29,30)/t18-/m0/s1
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white 384 ...


US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM309999
PNG
((S)-3-(1-((6-amino-5-(5-methyl-1,3,4-oxadiazol-2-y...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1cc2cccc(Cl)c2c(=O)n1C1CC1
Show InChI InChI=1S/C22H22ClN7O2/c1-3-15(27-20-18(19(24)25-10-26-20)21-29-28-11(2)32-21)16-9-12-5-4-6-14(23)17(12)22(31)30(16)13-7-8-13/h4-6,9-10,13,15H,3,7-8H2,1-2H3,(H3,24,25,26,27)/t15-/m0/s1
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white 384 ...


US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM259452
PNG
(US9512114, 12 | US9657007, Example 12)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nnn(C)n1)c1cc2cccc(Cl)c2c(=O)n1C1CC1
Show InChI InChI=1S/C20H20ClN9O/c1-10(25-18-16(17(22)23-9-24-18)19-26-28-29(2)27-19)14-8-11-4-3-5-13(21)15(11)20(31)30(14)12-6-7-12/h3-5,8-10,12H,6-7H2,1-2H3,(H3,22,23,24,25)/t10-/m0/s1
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white 384 ...


US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM259451
PNG
(US9512114, 11 | US9657007, Example 11)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1noc(C)n1)c1cc2cccc(Cl)c2c(=O)n1C1CC1
Show InChI InChI=1S/C21H20ClN7O2/c1-10(26-19-17(18(23)24-9-25-19)20-27-11(2)31-28-20)15-8-12-4-3-5-14(22)16(12)21(30)29(15)13-6-7-13/h3-5,8-10,13H,6-7H2,1-2H3,(H3,23,24,25,26)/t10-/m0/s1
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white 384 ...


US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM259459
PNG
(US9512114, 24 | US9657007, Example 24)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1cc2cccc(Cl)c2c(=O)n1C1CC1
Show InChI InChI=1S/C21H20ClN7O2/c1-10(26-19-17(18(23)24-9-25-19)20-27-11(2)28-31-20)15-8-12-4-3-5-14(22)16(12)21(30)29(15)13-6-7-13/h3-5,8-10,13H,6-7H2,1-2H3,(H3,23,24,25,26)/t10-/m0/s1
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent




US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM259456
PNG
(US9512114, 21 | US9657007, Example 21)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1noc(C)n1)c1cc2cccc(Cl)c2c(=O)n1C1CC1
Show InChI InChI=1S/C22H22ClN7O2/c1-3-15(28-20-18(19(24)25-10-26-20)21-27-11(2)32-29-21)16-9-12-5-4-6-14(23)17(12)22(31)30(16)13-7-8-13/h4-6,9-10,13,15H,3,7-8H2,1-2H3,(H3,24,25,26,28)/t15-/m0/s1
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white 384 ...


US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM259447
PNG
(US9512114, 6 | US9657007, Example 6)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1cc2cccc(C)c2c(=O)n1C1CC1
Show InChI InChI=1S/C23H25N7O2/c1-4-16(27-21-19(20(24)25-11-26-21)22-29-28-13(3)32-22)17-10-14-7-5-6-12(2)18(14)23(31)30(17)15-8-9-15/h5-7,10-11,15-16H,4,8-9H2,1-3H3,(H3,24,25,26,27)/t16-/m0/s1
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white 384 ...


US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM309999
PNG
((S)-3-(1-((6-amino-5-(5-methyl-1,3,4-oxadiazol-2-y...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1cc2cccc(Cl)c2c(=O)n1C1CC1
Show InChI InChI=1S/C22H22ClN7O2/c1-3-15(27-20-18(19(24)25-10-26-20)21-29-28-11(2)32-21)16-9-12-5-4-6-14(23)17(12)22(31)30(16)13-7-8-13/h4-6,9-10,13,15H,3,7-8H2,1-2H3,(H3,24,25,26,27)/t15-/m0/s1
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n/an/a 30n/an/an/an/an/an/a



CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent




US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM259454
PNG
(US9512114, 18 | US9657007, Example 18)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1noc(C)n1)c1cc2cccc(F)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C25H22FN7O2/c1-3-18(31-23-21(22(27)28-13-29-23)24-30-14(2)35-32-24)19-12-15-8-7-11-17(26)20(15)25(34)33(19)16-9-5-4-6-10-16/h4-13,18H,3H2,1-2H3,(H3,27,28,29,31)/t18-/m0/s1
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white 384 ...


US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM259449
PNG
(US9512114, 8 | US9657007, Example 8)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C24H20ClN7O2/c1-13(29-22-20(21(26)27-12-28-22)23-30-14(2)31-34-23)18-11-15-7-6-10-17(25)19(15)24(33)32(18)16-8-4-3-5-9-16/h3-13H,1-2H3,(H3,26,27,28,29)/t13-/m0/s1
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n/an/a 33n/an/an/an/an/an/a



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US Patent




US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM259459
PNG
(US9512114, 24 | US9657007, Example 24)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1cc2cccc(Cl)c2c(=O)n1C1CC1
Show InChI InChI=1S/C21H20ClN7O2/c1-10(26-19-17(18(23)24-9-25-19)20-27-11(2)28-31-20)15-8-12-4-3-5-14(22)16(12)21(30)29(15)13-6-7-13/h3-5,8-10,13H,6-7H2,1-2H3,(H3,23,24,25,26)/t10-/m0/s1
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US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM259455
PNG
(US9512114, 19 | US9657007, Example 19)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1ccon1)c1cc2cccc(F)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C25H21FN6O2/c1-2-18(30-24-22(19-11-12-34-31-19)23(27)28-14-29-24)20-13-15-7-6-10-17(26)21(15)25(33)32(20)16-8-4-3-5-9-16/h3-14,18H,2H2,1H3,(H3,27,28,29,30)/t18-/m0/s1
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Assay Description
Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white 384 ...


US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM259449
PNG
(US9512114, 8 | US9657007, Example 8)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C24H20ClN7O2/c1-13(29-22-20(21(26)27-12-28-22)23-30-14(2)31-34-23)18-11-15-7-6-10-17(25)19(15)24(33)32(18)16-8-4-3-5-9-16/h3-13H,1-2H3,(H3,26,27,28,29)/t13-/m0/s1
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US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM259451
PNG
(US9512114, 11 | US9657007, Example 11)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1noc(C)n1)c1cc2cccc(Cl)c2c(=O)n1C1CC1
Show InChI InChI=1S/C21H20ClN7O2/c1-10(26-19-17(18(23)24-9-25-19)20-27-11(2)31-28-20)15-8-12-4-3-5-14(22)16(12)21(30)29(15)13-6-7-13/h3-5,8-10,13H,6-7H2,1-2H3,(H3,23,24,25,26)/t10-/m0/s1
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n/an/a 102n/an/an/an/an/an/a



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US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM259453
PNG
(US9512114, 16 | US9657007, Example 16)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1ncn(C)n1)c1cc2cccc(Cl)c2c(=O)n1C1CC1
Show InChI InChI=1S/C21H21ClN8O/c1-11(27-19-17(18(23)24-9-25-19)20-26-10-29(2)28-20)15-8-12-4-3-5-14(22)16(12)21(31)30(15)13-6-7-13/h3-5,8-11,13H,6-7H2,1-2H3,(H3,23,24,25,27)/t11-/m0/s1
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US Patent


Assay Description
Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white 384 ...


US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM259450
PNG
(US9512114, 9 | US9657007, Example 9)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C24H20ClN7O2/c1-13(29-22-20(21(26)27-12-28-22)23-31-30-14(2)34-23)18-11-15-7-6-10-17(25)19(15)24(33)32(18)16-8-4-3-5-9-16/h3-13H,1-2H3,(H3,26,27,28,29)/t13-/m0/s1
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n/an/a 226n/an/an/an/an/an/a



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US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM259450
PNG
(US9512114, 9 | US9657007, Example 9)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C24H20ClN7O2/c1-13(29-22-20(21(26)27-12-28-22)23-31-30-14(2)34-23)18-11-15-7-6-10-17(25)19(15)24(33)32(18)16-8-4-3-5-9-16/h3-13H,1-2H3,(H3,26,27,28,29)/t13-/m0/s1
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n/an/a 255n/an/an/an/an/an/a



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US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM259446
PNG
(US9512114, 5 | US9657007, Example 5)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C25H22ClN7O2/c1-3-18(30-23-21(22(27)28-13-29-23)24-32-31-14(2)35-24)19-12-15-8-7-11-17(26)20(15)25(34)33(19)16-9-5-4-6-10-16/h4-13,18H,3H2,1-2H3,(H3,27,28,29,30)/t18-/m0/s1
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US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM259449
PNG
(US9512114, 8 | US9657007, Example 8)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C24H20ClN7O2/c1-13(29-22-20(21(26)27-12-28-22)23-30-14(2)31-34-23)18-11-15-7-6-10-17(25)19(15)24(33)32(18)16-8-4-3-5-9-16/h3-13H,1-2H3,(H3,26,27,28,29)/t13-/m0/s1
PDB

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n/an/a 276n/an/an/an/an/an/a



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US Patent




US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM259459
PNG
(US9512114, 24 | US9657007, Example 24)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1cc2cccc(Cl)c2c(=O)n1C1CC1
Show InChI InChI=1S/C21H20ClN7O2/c1-10(26-19-17(18(23)24-9-25-19)20-27-11(2)28-31-20)15-8-12-4-3-5-14(22)16(12)21(30)29(15)13-6-7-13/h3-5,8-10,13H,6-7H2,1-2H3,(H3,23,24,25,26)/t10-/m0/s1
PDB

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n/an/a 307n/an/an/an/an/an/a



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US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM259451
PNG
(US9512114, 11 | US9657007, Example 11)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1noc(C)n1)c1cc2cccc(Cl)c2c(=O)n1C1CC1
Show InChI InChI=1S/C21H20ClN7O2/c1-10(26-19-17(18(23)24-9-25-19)20-27-11(2)31-28-20)15-8-12-4-3-5-14(22)16(12)21(30)29(15)13-6-7-13/h3-5,8-10,13H,6-7H2,1-2H3,(H3,23,24,25,26)/t10-/m0/s1
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US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM309999
PNG
((S)-3-(1-((6-amino-5-(5-methyl-1,3,4-oxadiazol-2-y...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1cc2cccc(Cl)c2c(=O)n1C1CC1
Show InChI InChI=1S/C22H22ClN7O2/c1-3-15(27-20-18(19(24)25-10-26-20)21-29-28-11(2)32-21)16-9-12-5-4-6-14(23)17(12)22(31)30(16)13-7-8-13/h4-6,9-10,13,15H,3,7-8H2,1-2H3,(H3,24,25,26,27)/t15-/m0/s1
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n/an/a 387n/an/an/an/an/an/a



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US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM259446
PNG
(US9512114, 5 | US9657007, Example 5)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C25H22ClN7O2/c1-3-18(30-23-21(22(27)28-13-29-23)24-32-31-14(2)35-24)19-12-15-8-7-11-17(26)20(15)25(34)33(19)16-9-5-4-6-10-16/h4-13,18H,3H2,1-2H3,(H3,27,28,29,30)/t18-/m0/s1
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n/an/a 388n/an/an/an/an/an/a



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US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM309999
PNG
((S)-3-(1-((6-amino-5-(5-methyl-1,3,4-oxadiazol-2-y...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1cc2cccc(Cl)c2c(=O)n1C1CC1
Show InChI InChI=1S/C22H22ClN7O2/c1-3-15(27-20-18(19(24)25-10-26-20)21-29-28-11(2)32-21)16-9-12-5-4-6-14(23)17(12)22(31)30(16)13-7-8-13/h4-6,9-10,13,15H,3,7-8H2,1-2H3,(H3,24,25,26,27)/t15-/m0/s1
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n/an/a 1.47E+3n/an/an/an/an/an/a



CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent




US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM259451
PNG
(US9512114, 11 | US9657007, Example 11)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1noc(C)n1)c1cc2cccc(Cl)c2c(=O)n1C1CC1
Show InChI InChI=1S/C21H20ClN7O2/c1-10(26-19-17(18(23)24-9-25-19)20-27-11(2)31-28-20)15-8-12-4-3-5-14(22)16(12)21(30)29(15)13-6-7-13/h3-5,8-10,13H,6-7H2,1-2H3,(H3,23,24,25,26)/t10-/m0/s1
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n/an/a 1.48E+3n/an/an/an/an/an/a



CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent




US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM259450
PNG
(US9512114, 9 | US9657007, Example 9)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C24H20ClN7O2/c1-13(29-22-20(21(26)27-12-28-22)23-31-30-14(2)34-23)18-11-15-7-6-10-17(25)19(15)24(33)32(18)16-8-4-3-5-9-16/h3-13H,1-2H3,(H3,26,27,28,29)/t13-/m0/s1
PDB

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n/an/a 2.68E+3n/an/an/an/an/an/a



CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

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US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM259446
PNG
(US9512114, 5 | US9657007, Example 5)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C25H22ClN7O2/c1-3-18(30-23-21(22(27)28-13-29-23)24-32-31-14(2)35-24)19-12-15-8-7-11-17(26)20(15)25(34)33(19)16-9-5-4-6-10-16/h4-13,18H,3H2,1-2H3,(H3,27,28,29,30)/t18-/m0/s1
PDB

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n/an/a>3.00E+3n/an/an/an/an/an/a



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US Patent US9657007 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%