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Patent code US9663470

Compile Data Set for Download or QSAR
Found 177 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM327951
PNG
((1H-Benzoimidazol-5-yl)-(cis-6-methoxy-7-methyl-2,...)
Show SMILES COc1cc2[C@H]3CCCN([C@H]3Cc2cc1C)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C22H23N3O2/c1-13-8-15-10-20-16(17(15)11-21(13)27-2)4-3-7-25(20)22(26)14-5-6-18-19(9-14)24-12-23-18/h5-6,8-9,11-12,16,20H,3-4,7,10H2,1-2H3,(H,23,24)/t16-,20+/m1/s1
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US Patent
n/an/a 5.60n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM327952
PNG
((1H-Benzoimidazol-5-yl)-(cis-6-hydroxy-7-methyl-2,...)
Show SMILES Cc1cc2C[C@H]3[C@H](CCCN3C(=O)c3ccc4[nH]cnc4c3)c2cc1O
Show InChI InChI=1S/C21H21N3O2/c1-12-7-14-9-19-15(16(14)10-20(12)25)3-2-6-24(19)21(26)13-4-5-17-18(8-13)23-11-22-17/h4-5,7-8,10-11,15,19,25H,2-3,6,9H2,1H3,(H,22,23)/t15-,19+/m1/s1
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n/an/a 18.6n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177650
PNG
(US9120769, 152 | US9663470, 152)
Show SMILES Cc1cc(cc2nc[nH]c12)C(=O)N1CCC[C@H]2[C@@H]1Cc1ccc(cc21)C#N
Show InChI InChI=1S/C22H20N4O/c1-13-7-16(9-19-21(13)25-12-24-19)22(27)26-6-2-3-17-18-8-14(11-23)4-5-15(18)10-20(17)26/h4-5,7-9,12,17,20H,2-3,6,10H2,1H3,(H,24,25)/t17-,20+/m1/s1
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n/an/a 24n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177639
PNG
(US9120769, 107 | US9663470, 107)
Show SMILES O=C(N1CCC[C@H]2[C@@H]1Cc1ccc(cc21)C#N)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C21H18N4O/c22-11-13-3-4-14-10-20-16(17(14)8-13)2-1-7-25(20)21(26)15-5-6-18-19(9-15)24-12-23-18/h3-6,8-9,12,16,20H,1-2,7,10H2,(H,23,24)/t16-,20+/m1/s1
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n/an/a 26n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177638
PNG
(US9120769, 106 | US9663470, 106)
Show SMILES O=C(N1CCCC2[C@@H]1Cc1ccc(cc21)C#N)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C21H18N4O/c22-11-13-3-4-14-10-20-16(17(14)8-13)2-1-7-25(20)21(26)15-5-6-18-19(9-15)24-12-23-18/h3-6,8-9,12,16,20H,1-2,7,10H2,(H,23,24)/t16?,20-/m0/s1
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n/an/a 31n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM327954
PNG
((4a-R,9a-S)-1-(1H-Benzoimidazole-5-carbonyl)-5-met...)
Show SMILES Cc1c2[C@H]3CCCN([C@H]3Cc2ccc1C#N)C(=O)c1ccc2ncnc2c1
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n/an/a 46.5n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177651
PNG
(US9120769, 153 | US9663470, 153)
Show SMILES Cc1cc2[nH]cnc2cc1C(=O)N1CCC[C@H]2[C@@H]1Cc1ccc(cc21)C#N
Show InChI InChI=1S/C22H20N4O/c1-13-7-19-20(25-12-24-19)10-17(13)22(27)26-6-2-3-16-18-8-14(11-23)4-5-15(18)9-21(16)26/h4-5,7-8,10,12,16,21H,2-3,6,9H2,1H3,(H,24,25)/t16-,21+/m1/s1
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n/an/a 48n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177645
PNG
(US9120769, 146 | US9663470, 146)
Show SMILES C[C@H]1CCN([C@H]2Cc3ccccc3[C@@H]12)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C21H21N3O/c1-13-8-9-24(19-11-14-4-2-3-5-16(14)20(13)19)21(25)15-6-7-17-18(10-15)23-12-22-17/h2-7,10,12-13,19-20H,8-9,11H2,1H3,(H,22,23)/t13-,19-,20+/m0/s1
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n/an/a 55n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM327953
PNG
((4a-S,9a-R)-1-(1H-Benzoimidazole-5-carbonyl)-7-met...)
Show SMILES Cc1cc2C[C@H]3[C@H](CCCN3C(=O)c3ccc4ncnc4c3)c2cc1C#N
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n/an/a 58.4n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM327780
PNG
((1H-Benzoimidazol-5-yl)-[(4a-S,10b-R)-2,3, 4a,5,6,...)
Show SMILES O=C(N1CCC[C@H]2[C@@H]1CCc1ccccc21)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C21H21N3O/c25-21(15-7-9-18-19(12-15)23-13-22-18)24-11-3-6-17-16-5-2-1-4-14(16)8-10-20(17)24/h1-2,4-5,7,9,12-13,17,20H,3,6,8,10-11H2,(H,22,23)/t17-,20+/m1/s1
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n/an/a 65n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177672
PNG
(US9120769, 174 | US9663470, 174)
Show SMILES Cc1cc2C[C@H]3[C@H](CCCN3C(=O)c3ccc4[nH]cnc4c3)c2cc1C#N
Show InChI InChI=1S/C22H20N4O/c1-13-7-15-10-21-17(18(15)8-16(13)11-23)3-2-6-26(21)22(27)14-4-5-19-20(9-14)25-12-24-19/h4-5,7-9,12,17,21H,2-3,6,10H2,1H3,(H,24,25)/t17-,21+/m1/s1
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n/an/a 67n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177661
PNG
(US9120769, 163 | US9663470, 163)
Show SMILES Cc1ccc2C[C@H]3[C@H](CCCN3C(=O)c3ccc4[nH]cnc4c3)c2c1
Show InChI InChI=1S/C21H21N3O/c1-13-4-5-14-11-20-16(17(14)9-13)3-2-8-24(20)21(25)15-6-7-18-19(10-15)23-12-22-18/h4-7,9-10,12,16,20H,2-3,8,11H2,1H3,(H,22,23)/t16-,20+/m1/s1
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n/an/a 67n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177653
PNG
(US9120769, 155 | US9663470, 155)
Show SMILES O=C(N1CCC[C@H]2[C@@H]1Cc1ccc(cc21)C#C)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C22H19N3O/c1-2-14-5-6-15-12-21-17(18(15)10-14)4-3-9-25(21)22(26)16-7-8-19-20(11-16)24-13-23-19/h1,5-8,10-11,13,17,21H,3-4,9,12H2,(H,23,24)/t17-,21+/m1/s1
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n/an/a 83n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177629
PNG
(US9120769, 93 | US9663470, 94)
Show SMILES O=C(N1CCCC2[C@@H]1Cc1ccccc21)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C20H19N3O/c24-20(14-7-8-17-18(10-14)22-12-21-17)23-9-3-6-16-15-5-2-1-4-13(15)11-19(16)23/h1-2,4-5,7-8,10,12,16,19H,3,6,9,11H2,(H,21,22)/t16?,19-/m0/s1
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n/an/a 90n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177587
PNG
(US9120769, 11 | US9663470, 11)
Show SMILES C[C@]12CCCN([C@@H]1CCc1ccccc21)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C22H23N3O/c1-22-11-4-12-25(20(22)10-8-15-5-2-3-6-17(15)22)21(26)16-7-9-18-19(13-16)24-14-23-18/h2-3,5-7,9,13-14,20H,4,8,10-12H2,1H3,(H,23,24)/t20-,22-/m1/s1
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n/an/a 94n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM327955
PNG
((4a-S,9a-R)-1-(1H-Benzoimidazole-5-carbonyl)-5-met...)
Show SMILES Cc1c2[C@@H]3CCCN([C@@H]3Cc2ccc1C#N)C(=O)c1ccc2ncnc2c1
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n/an/a>100n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177578
PNG
(US9120769, 1 | US9120769, 2 | US9663470, 1)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C21H21N3O/c25-21(15-7-9-18-19(12-15)23-13-22-18)24-11-3-6-17-16-5-2-1-4-14(16)8-10-20(17)24/h1-2,4-5,7,9,12-13,17,20H,3,6,8,10-11H2,(H,22,23)/t17?,20-/m0/s1
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n/an/a 106n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177629
PNG
(US9120769, 93 | US9663470, 94)
Show SMILES O=C(N1CCCC2[C@@H]1Cc1ccccc21)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C20H19N3O/c24-20(14-7-8-17-18(10-14)22-12-21-17)23-9-3-6-16-15-5-2-1-4-13(15)11-19(16)23/h1-2,4-5,7-8,10,12,16,19H,3,6,9,11H2,(H,21,22)/t16?,19-/m0/s1
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n/an/a 121n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177598
PNG
(US9120769, 22 | US9663470, 22)
Show SMILES COc1ccc2C3CCCN([C@H]3CCc2c1)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C22H23N3O2/c1-27-16-6-7-17-14(11-16)5-9-21-18(17)3-2-10-25(21)22(26)15-4-8-19-20(12-15)24-13-23-19/h4,6-8,11-13,18,21H,2-3,5,9-10H2,1H3,(H,23,24)/t18?,21-/m0/s1
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n/an/a 123n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177647
PNG
(US9120769, 149 | US9663470, 149)
Show SMILES COc1ccc2C[C@H]3[C@H](CCCN3C(=O)c3ccc4[nH]cnc4c3)c2c1
Show InChI InChI=1S/C21H21N3O2/c1-26-15-6-4-13-10-20-16(17(13)11-15)3-2-8-24(20)21(25)14-5-7-18-19(9-14)23-12-22-18/h4-7,9,11-12,16,20H,2-3,8,10H2,1H3,(H,22,23)/t16-,20+/m1/s1
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n/an/a 141n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177610
PNG
(US9120769, 37 | US9663470, 37)
Show SMILES NC(=O)c1ccc2C3CCCN([C@H]3CCc2c1)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C22H22N4O2/c23-21(27)14-3-6-16-13(10-14)5-8-20-17(16)2-1-9-26(20)22(28)15-4-7-18-19(11-15)25-12-24-18/h3-4,6-7,10-12,17,20H,1-2,5,8-9H2,(H2,23,27)(H,24,25)/t17?,20-/m0/s1
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n/an/a 150n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177640
PNG
(US9120769, 108 | US9663470, 108)
Show SMILES O=C(N1CCC[C@@H]2[C@H]1Cc1ccc(cc21)C#N)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C21H18N4O/c22-11-13-3-4-14-10-20-16(17(14)8-13)2-1-7-25(20)21(26)15-5-6-18-19(9-15)24-12-23-18/h3-6,8-9,12,16,20H,1-2,7,10H2,(H,23,24)/t16-,20+/m0/s1
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n/an/a 150n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177664
PNG
(US9120769, 166 | US9663470, 166)
Show SMILES CC(=O)Nc1ccc2[C@H]3CCCN([C@H]3Cc2c1)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C22H22N4O2/c1-13(27)25-16-5-6-17-15(9-16)11-21-18(17)3-2-8-26(21)22(28)14-4-7-19-20(10-14)24-12-23-19/h4-7,9-10,12,18,21H,2-3,8,11H2,1H3,(H,23,24)(H,25,27)/t18-,21+/m1/s1
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n/an/a 182n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99403
PNG
(US8497281, 181 | US9120769, 114 | US9663470, 114)
Show SMILES O=C(N1CCCC2[C@@H]1Cc1ccccc21)c1ccc2cc[nH]c2c1
Show InChI InChI=1S/C21H20N2O/c24-21(16-8-7-14-9-10-22-19(14)12-16)23-11-3-6-18-17-5-2-1-4-15(17)13-20(18)23/h1-2,4-5,7-10,12,18,20,22H,3,6,11,13H2/t18?,20-/m0/s1
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n/an/a 185n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177649
PNG
(US9120769, 151 | US9663470, 151)
Show SMILES Nc1ccc2[C@H]3CCCN([C@H]3Cc2c1)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C20H20N4O/c21-14-4-5-15-13(8-14)10-19-16(15)2-1-7-24(19)20(25)12-3-6-17-18(9-12)23-11-22-17/h3-6,8-9,11,16,19H,1-2,7,10,21H2,(H,22,23)/t16-,19+/m1/s1
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n/an/a 188n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99354
PNG
(US8497281, 132 | US9120769, 65 | US9663470, 65)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C21H21N3O/c25-21(15-7-9-19-16(12-15)13-22-23-19)24-11-3-6-18-17-5-2-1-4-14(17)8-10-20(18)24/h1-2,4-5,7,9,12-13,18,20H,3,6,8,10-11H2,(H,22,23)/t18?,20-/m0/s1
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n/an/a 212n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177659
PNG
(US9120769, 161 | US9663470, 161)
Show SMILES CC#Cc1ccc2C[C@H]3[C@H](CCCN3C(=O)c3ccc4[nH]cnc4c3)c2c1
Show InChI InChI=1S/C23H21N3O/c1-2-4-15-6-7-16-13-22-18(19(16)11-15)5-3-10-26(22)23(27)17-8-9-20-21(12-17)25-14-24-20/h6-9,11-12,14,18,22H,3,5,10,13H2,1H3,(H,24,25)/t18-,22+/m1/s1
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n/an/a 212n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177646
PNG
(US9120769, 148 | US9663470, 148)
Show SMILES O=C(N1CCC[C@H]2[C@@H]1Cc1cc(ccc21)C#N)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C21H18N4O/c22-11-13-3-5-16-15(8-13)10-20-17(16)2-1-7-25(20)21(26)14-4-6-18-19(9-14)24-12-23-18/h3-6,8-9,12,17,20H,1-2,7,10H2,(H,23,24)/t17-,20+/m1/s1
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n/an/a 214n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177669
PNG
(US9120769, 171 | US9663470, 171)
Show SMILES O=C(N1CCC[C@H]2[C@@H]1Cc1cc3ncoc3cc21)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C21H18N4O2/c26-21(12-3-4-16-17(6-12)23-10-22-16)25-5-1-2-14-15-9-20-18(24-11-27-20)7-13(15)8-19(14)25/h3-4,6-7,9-11,14,19H,1-2,5,8H2,(H,22,23)/t14-,19+/m1/s1
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n/an/a 218n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177596
PNG
(US9120769, 20 | US9663470, 20)
Show SMILES Fc1cc(F)c2CC[C@H]3C(CCCN3C(=O)c3ccc4[nH]cnc4c3)c2c1
Show InChI InChI=1S/C21H19F2N3O/c22-13-9-16-14(17(23)10-13)4-6-20-15(16)2-1-7-26(20)21(27)12-3-5-18-19(8-12)25-11-24-18/h3,5,8-11,15,20H,1-2,4,6-7H2,(H,24,25)/t15?,20-/m0/s1
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n/an/a 227n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99411
PNG
(US8497281, 189 | US9120769, 122 | US9663470, 122)
Show SMILES Nc1ccc(cc1Cl)C(=O)N1CCCC2[C@@H]1Cc1ccccc21
Show InChI InChI=1S/C19H19ClN2O/c20-16-10-13(7-8-17(16)21)19(23)22-9-3-6-15-14-5-2-1-4-12(14)11-18(15)22/h1-2,4-5,7-8,10,15,18H,3,6,9,11,21H2/t15?,18-/m0/s1
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n/an/a 230n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177627
PNG
(US9120769, 91 | US9663470, 91)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccc(cc21)C#N)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C22H20N4O/c23-12-14-3-4-15-6-8-21-17(18(15)10-14)2-1-9-26(21)22(27)16-5-7-19-20(11-16)25-13-24-19/h3-5,7,10-11,13,17,21H,1-2,6,8-9H2,(H,24,25)/t17?,21-/m0/s1
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n/an/a 244n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177668
PNG
(US9120769, 170 | US9663470, 170)
Show SMILES Cc1nc2cc3C[C@H]4[C@H](CCCN4C(=O)c4ccc5[nH]cnc5c4)c3cc2o1
Show InChI InChI=1S/C22H20N4O2/c1-12-25-19-8-14-9-20-15(16(14)10-21(19)28-12)3-2-6-26(20)22(27)13-4-5-17-18(7-13)24-11-23-17/h4-5,7-8,10-11,15,20H,2-3,6,9H2,1H3,(H,23,24)/t15-,20+/m1/s1
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n/an/a 248n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99367
PNG
(US8497281, 145 | US9120769, 78 | US9663470, 78)
Show SMILES COc1cc(ccc1N)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C21H24N2O2/c1-25-20-13-15(8-10-18(20)22)21(24)23-12-4-7-17-16-6-3-2-5-14(16)9-11-19(17)23/h2-3,5-6,8,10,13,17,19H,4,7,9,11-12,22H2,1H3/t17?,19-/m0/s1
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n/an/a 257n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177589
PNG
(US9120769, 13 | US9663470, 13)
Show SMILES Oc1cccc2CC[C@H]3C(CCCN3C(=O)c3ccc4[nH]cnc4c3)c12
Show InChI InChI=1S/C21H21N3O2/c25-19-5-1-3-13-7-9-18-15(20(13)19)4-2-10-24(18)21(26)14-6-8-16-17(11-14)23-12-22-16/h1,3,5-6,8,11-12,15,18,25H,2,4,7,9-10H2,(H,22,23)/t15?,18-/m0/s1
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n/an/a 257n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177637
PNG
(US9120769, 105 | US9663470, 105)
Show SMILES CC[C@]12CCCN([C@@H]1CCc1ccccc21)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C23H25N3O/c1-2-23-12-5-13-26(21(23)11-9-16-6-3-4-7-18(16)23)22(27)17-8-10-19-20(14-17)25-15-24-19/h3-4,6-8,10,14-15,21H,2,5,9,11-13H2,1H3,(H,24,25)/t21-,23-/m1/s1
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n/an/a 263n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177582
PNG
(US9120769, 6 | US9663470, 6)
Show SMILES COc1cccc2C3CCCN([C@H]3CCc12)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C22H23N3O2/c1-27-21-6-2-4-15-16-5-3-11-25(20(16)10-8-17(15)21)22(26)14-7-9-18-19(12-14)24-13-23-18/h2,4,6-7,9,12-13,16,20H,3,5,8,10-11H2,1H3,(H,23,24)/t16?,20-/m0/s1
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n/an/a 296n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM327805
PNG
(US9663470, 27 | cis-8-(4-Methoxy-phenoxy)-1,2,3,4,...)
Show SMILES COc1ccc(Cc2ccc3C4CCCN([C@H]4CCc3c2)C(=O)C(F)(F)F)cc1
Show InChI InChI=1S/C23H24F3NO2/c1-29-18-8-4-15(5-9-18)13-16-6-10-19-17(14-16)7-11-21-20(19)3-2-12-27(21)22(28)23(24,25)26/h4-6,8-10,14,20-21H,2-3,7,11-13H2,1H3/t20?,21-/m0/s1
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n/an/a 297n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177609
PNG
(US9120769, 36 | US9663470, 36)
Show SMILES CNC(=O)c1ccc2C3CCCN([C@H]3CCc2c1)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C23H24N4O2/c1-24-22(28)15-4-7-17-14(11-15)6-9-21-18(17)3-2-10-27(21)23(29)16-5-8-19-20(12-16)26-13-25-19/h4-5,7-8,11-13,18,21H,2-3,6,9-10H2,1H3,(H,24,28)(H,25,26)/t18?,21-/m0/s1
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n/an/a 310n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177666
PNG
(US9120769, 168 | US9663470, 168)
Show SMILES Oc1cc2[C@H]3CCCN([C@H]3Cc2cc1[N+]([O-])=O)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C20H18N4O4/c25-19-9-14-12(8-18(19)24(27)28)7-17-13(14)2-1-5-23(17)20(26)11-3-4-15-16(6-11)22-10-21-15/h3-4,6,8-10,13,17,25H,1-2,5,7H2,(H,21,22)/t13-,17+/m1/s1
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n/an/a 313n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99421
PNG
(US8497281, 199 | US9120769, 132 | US9663470, 132)
Show SMILES O=C(N1CCCC2[C@@H]1Cc1ccccc21)c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C20H19N3O/c24-20(14-7-8-18-15(10-14)12-21-22-18)23-9-3-6-17-16-5-2-1-4-13(16)11-19(17)23/h1-2,4-5,7-8,10,12,17,19H,3,6,9,11H2,(H,21,22)/t17?,19-/m0/s1
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n/an/a 320n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177586
PNG
(US9120769, 10 | US9663470, 10)
Show SMILES C[C@]12CCCN([C@H]1CCc1ccccc21)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C22H23N3O/c1-22-11-4-12-25(20(22)10-8-15-5-2-3-6-17(15)22)21(26)16-7-9-18-19(13-16)24-14-23-18/h2-3,5-7,9,13-14,20H,4,8,10-12H2,1H3,(H,23,24)/t20-,22+/m0/s1
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n/an/a 321n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99364
PNG
(US8497281, 142 | US9120769, 75 | US9663470, 75)
Show SMILES Oc1ccc(cc1Cl)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C20H20ClNO2/c21-17-12-14(8-10-19(17)23)20(24)22-11-3-6-16-15-5-2-1-4-13(15)7-9-18(16)22/h1-2,4-5,8,10,12,16,18,23H,3,6-7,9,11H2/t16?,18-/m0/s1
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n/an/a 324n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99430
PNG
(US8497281, 208 | US9120769, 141 | US9663470, 141)
Show SMILES Oc1ccc(cc1Cl)C(=O)N1CCCC2[C@@H]1Cc1ccccc21
Show InChI InChI=1S/C19H18ClNO2/c20-16-10-13(7-8-18(16)22)19(23)21-9-3-6-15-14-5-2-1-4-12(14)11-17(15)21/h1-2,4-5,7-8,10,15,17,22H,3,6,9,11H2/t15?,17-/m0/s1
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n/an/a 326n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177584
PNG
(US9120769, 8 | US9663470, 8)
Show SMILES COc1cccc2CC[C@H]3C(CCCN3C(=O)c3ccc4[nH]cnc4c3)c12
Show InChI InChI=1S/C22H23N3O2/c1-27-20-6-2-4-14-8-10-19-16(21(14)20)5-3-11-25(19)22(26)15-7-9-17-18(12-15)24-13-23-17/h2,4,6-7,9,12-13,16,19H,3,5,8,10-11H2,1H3,(H,23,24)/t16?,19-/m0/s1
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n/an/a 342n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99359
PNG
(US8497281, 137 | US9120769, 70 | US9663470, 70)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1c[nH]c2ccccc12
Show InChI InChI=1S/C22H22N2O/c25-22(19-14-23-20-10-4-3-8-17(19)20)24-13-5-9-18-16-7-2-1-6-15(16)11-12-21(18)24/h1-4,6-8,10,14,18,21,23H,5,9,11-13H2/t18?,21-/m0/s1
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n/an/a 350n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177660
PNG
(US9120769, 162 | US9663470, 162)
Show SMILES Cn1cc(cn1)-c1ccc2C[C@H]3[C@H](CCCN3C(=O)c3ccc4[nH]cnc4c3)c2c1
Show InChI InChI=1S/C24H23N5O/c1-28-13-18(12-27-28)15-4-5-16-11-23-19(20(16)9-15)3-2-8-29(23)24(30)17-6-7-21-22(10-17)26-14-25-21/h4-7,9-10,12-14,19,23H,2-3,8,11H2,1H3,(H,25,26)/t19-,23+/m1/s1
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n/an/a 354n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99345
PNG
(US8497281, 123 | US9120769, 56 | US9663470, 56)
Show SMILES Nc1ccc(cc1Cl)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C20H21ClN2O/c21-17-12-14(7-9-18(17)22)20(24)23-11-3-6-16-15-5-2-1-4-13(15)8-10-19(16)23/h1-2,4-5,7,9,12,16,19H,3,6,8,10-11,22H2/t16?,19-/m0/s1
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n/an/a 356n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177641
PNG
(US9120769, 119 | US9663470, 119)
Show SMILES Oc1ccc2[C@H]3CCCN([C@H]3Cc2c1)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C20H19N3O2/c24-14-4-5-15-13(8-14)10-19-16(15)2-1-7-23(19)20(25)12-3-6-17-18(9-12)22-11-21-17/h3-6,8-9,11,16,19,24H,1-2,7,10H2,(H,21,22)/t16-,19+/m1/s1
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n/an/a 365n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177658
PNG
(US9120769, 160 | US9663470, 160)
Show SMILES O=C(N1CCC[C@H]2[C@@H]1Cc1ccc(cc21)-c1ccoc1)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C24H21N3O2/c28-24(17-5-6-21-22(11-17)26-14-25-21)27-8-1-2-19-20-10-15(18-7-9-29-13-18)3-4-16(20)12-23(19)27/h3-7,9-11,13-14,19,23H,1-2,8,12H2,(H,25,26)/t19-,23+/m1/s1
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n/an/a 367n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177588
PNG
(US9120769, 12 | US9663470, 12)
Show SMILES COc1cccc2C3CCCN([C@@H]3CCc12)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C22H23N3O2/c1-27-21-6-2-4-15-16-5-3-11-25(20(16)10-8-17(15)21)22(26)14-7-9-18-19(12-14)24-13-23-18/h2,4,6-7,9,12-13,16,20H,3,5,8,10-11H2,1H3,(H,23,24)/t16?,20-/m1/s1
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n/an/a 367n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99358
PNG
(US8497281, 136 | US9120769, 69 | US9663470, 69)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C22H22N2O/c25-22(17-7-9-20-16(14-17)11-12-23-20)24-13-3-6-19-18-5-2-1-4-15(18)8-10-21(19)24/h1-2,4-5,7,9,11-12,14,19,21,23H,3,6,8,10,13H2/t19?,21-/m0/s1
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n/an/a 371n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99409
PNG
(US8497281, 187 | US9120769, 120 | US9663470, 120)
Show SMILES Cc1cc(ccc1O)C(=O)N1CCCC2[C@@H]1Cc1ccccc21
Show InChI InChI=1S/C20H21NO2/c1-13-11-15(8-9-19(13)22)20(23)21-10-4-7-17-16-6-3-2-5-14(16)12-18(17)21/h2-3,5-6,8-9,11,17-18,22H,4,7,10,12H2,1H3/t17?,18-/m0/s1
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n/an/a 383n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99423
PNG
(US8497281, 201 | US9120769, 134 | US9663470, 134)
Show SMILES Oc1ccc(cc1)C(=O)N1CCCC2[C@@H]1Cc1ccccc21
Show InChI InChI=1S/C19H19NO2/c21-15-9-7-13(8-10-15)19(22)20-11-3-6-17-16-5-2-1-4-14(16)12-18(17)20/h1-2,4-5,7-10,17-18,21H,3,6,11-12H2/t17?,18-/m0/s1
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n/an/a 389n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177590
PNG
(US9120769, 14 | US9663470, 14)
Show SMILES COc1ccc2CC[C@H]3C(CCCN3C(=O)c3ccc4[nH]cnc4c3)c2c1
Show InChI InChI=1S/C22H23N3O2/c1-27-16-7-4-14-6-9-21-17(18(14)12-16)3-2-10-25(21)22(26)15-5-8-19-20(11-15)24-13-23-19/h4-5,7-8,11-13,17,21H,2-3,6,9-10H2,1H3,(H,23,24)/t17?,21-/m0/s1
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n/an/a 405n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177583
PNG
(US9120769, 7 | US9663470, 7)
Show SMILES Oc1cccc2C3CCCN([C@H]3CCc12)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C21H21N3O2/c25-20-5-1-3-14-15-4-2-10-24(19(15)9-7-16(14)20)21(26)13-6-8-17-18(11-13)23-12-22-17/h1,3,5-6,8,11-12,15,19,25H,2,4,7,9-10H2,(H,22,23)/t15?,19-/m0/s1
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n/an/a 410n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM327820
PNG
(Trifluoromethanesulfonic acid cis-1-(1-trifluorome...)
Show SMILES FC(F)(F)S(=O)(=O)Oc1ccc2C[C@H]3C(CCCN3C(=O)c3ccc4n(cnc4c3)S(=O)(=O)C(F)(F)F)c2c1
Show InChI InChI=1S/C22H17F6N3O6S2/c23-21(24,25)38(33,34)31-11-29-17-8-13(4-6-18(17)31)20(32)30-7-1-2-15-16-10-14(5-3-12(16)9-19(15)30)37-39(35,36)22(26,27)28/h3-6,8,10-11,15,19H,1-2,7,9H2/t15?,19-/m0/s1
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n/an/a 418n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177667
PNG
(US9120769, 169 | US9663470, 169)
Show SMILES Nc1cc2C[C@H]3[C@H](CCCN3C(=O)c3ccc4[nH]cnc4c3)c2cc1O
Show InChI InChI=1S/C20H20N4O2/c21-15-6-12-8-18-13(14(12)9-19(15)25)2-1-5-24(18)20(26)11-3-4-16-17(7-11)23-10-22-16/h3-4,6-7,9-10,13,18,25H,1-2,5,8,21H2,(H,22,23)/t13-,18+/m1/s1
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n/an/a 429n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177654
PNG
(US9120769, 156 | US9663470, 156)
Show SMILES OCc1ccc2C[C@H]3[C@H](CCCN3C(=O)c3ccc4[nH]cnc4c3)c2c1
Show InChI InChI=1S/C21H21N3O2/c25-11-13-3-4-14-10-20-16(17(14)8-13)2-1-7-24(20)21(26)15-5-6-18-19(9-15)23-12-22-18/h3-6,8-9,12,16,20,25H,1-2,7,10-11H2,(H,22,23)/t16-,20+/m1/s1
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n/an/a 432n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99290
PNG
(US8497281, 135 | US8497281, 68 | US9120769, 68 | U...)
Show SMILES Oc1ccc(cc1)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C20H21NO2/c22-16-10-7-15(8-11-16)20(23)21-13-3-6-18-17-5-2-1-4-14(17)9-12-19(18)21/h1-2,4-5,7-8,10-11,18-19,22H,3,6,9,12-13H2/t18?,19-/m0/s1
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n/an/a 435n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99362
PNG
(US8497281, 140 | US9120769, 73 | US9663470, 73)
Show SMILES Cn1cc(C(=O)N2CCCC3[C@@H]2CCc2ccccc32)c2ccccc12
Show InChI InChI=1S/C23H24N2O/c1-24-15-20(19-9-4-5-11-21(19)24)23(26)25-14-6-10-18-17-8-3-2-7-16(17)12-13-22(18)25/h2-5,7-9,11,15,18,22H,6,10,12-14H2,1H3/t18?,22-/m0/s1
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n/an/a 447n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177652
PNG
(US9120769, 154 | US9663470, 154)
Show SMILES COC(=O)c1ccc2C[C@H]3[C@H](CCCN3C(=O)c3ccc4[nH]cnc4c3)c2c1
Show InChI InChI=1S/C22H21N3O3/c1-28-22(27)15-5-4-13-11-20-16(17(13)9-15)3-2-8-25(20)21(26)14-6-7-18-19(10-14)24-12-23-18/h4-7,9-10,12,16,20H,2-3,8,11H2,1H3,(H,23,24)/t16-,20+/m1/s1
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n/an/a 449n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177663
PNG
(US9120769, 165 | US9663470, 165)
Show SMILES O=C(N1CCC[C@H]2[C@@H]1Cc1ccc(cc21)C1CCCC1)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C25H27N3O/c29-25(19-9-10-22-23(13-19)27-15-26-22)28-11-3-6-20-21-12-17(16-4-1-2-5-16)7-8-18(21)14-24(20)28/h7-10,12-13,15-16,20,24H,1-6,11,14H2,(H,26,27)/t20-,24+/m1/s1
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n/an/a 449n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99320
PNG
(US8497281, 98 | US9120769, 31 | US9663470, 31)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2nccn2c1
Show InChI InChI=1S/C21H21N3O/c25-21(16-8-10-20-22-11-13-23(20)14-16)24-12-3-6-18-17-5-2-1-4-15(17)7-9-19(18)24/h1-2,4-5,8,10-11,13-14,18-19H,3,6-7,9,12H2/t18?,19-/m0/s1
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n/an/a 469n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99343
PNG
(US8497281, 121 | US9120769, 54 | US9663470, 54)
Show SMILES Oc1ccc(cc1F)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C20H20FNO2/c21-17-12-14(8-10-19(17)23)20(24)22-11-3-6-16-15-5-2-1-4-13(15)7-9-18(16)22/h1-2,4-5,8,10,12,16,18,23H,3,6-7,9,11H2/t16?,18-/m0/s1
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n/an/a 471n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177601
PNG
(US9120769, 25 | US9663470, 25)
Show SMILES Oc1ccc2C3CCCN([C@H]3CCc2c1)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C21H21N3O2/c25-15-5-6-16-13(10-15)4-8-20-17(16)2-1-9-24(20)21(26)14-3-7-18-19(11-14)23-12-22-18/h3,5-7,10-12,17,20,25H,1-2,4,8-9H2,(H,22,23)/t17?,20-/m0/s1
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n/an/a 475n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177585
PNG
(US9120769, 9 | US9663470, 9)
Show SMILES COc1cccc2CC[C@@H]3C(CCCN3C(=O)c3ccc4[nH]cnc4c3)c12
Show InChI InChI=1S/C22H23N3O2/c1-27-20-6-2-4-14-8-10-19-16(21(14)20)5-3-11-25(19)22(26)15-7-9-17-18(12-15)24-13-23-17/h2,4,6-7,9,12-13,16,19H,3,5,8,10-11H2,1H3,(H,23,24)/t16?,19-/m1/s1
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n/an/a 481n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM327903
PNG
(Benzothiazol-6-yl-(cis-2,3,4,4a,9,9a-hexahydro-ind...)
Show SMILES O=C(N1CCCC2[C@@H]1Cc1ccccc21)c1ccc2NC=[S]c2c1
Show InChI InChI=1S/C20H19N2OS/c23-20(14-7-8-17-19(11-14)24-12-21-17)22-9-3-6-16-15-5-2-1-4-13(15)10-18(16)22/h1-2,4-5,7-8,11-12,16,18,21H,3,6,9-10H2/t16?,18-/m0/s1
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n/an/a 484n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99428
PNG
(US8497281, 206 | US9120769, 139 | US9663470, 139)
Show SMILES Cn1cc(C(=O)N2CCCC3[C@@H]2Cc2ccccc32)c2ccccc12
Show InChI InChI=1S/C22H22N2O/c1-23-14-19(18-9-4-5-11-20(18)23)22(25)24-12-6-10-17-16-8-3-2-7-15(16)13-21(17)24/h2-5,7-9,11,14,17,21H,6,10,12-13H2,1H3/t17?,21-/m0/s1
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n/an/a 484n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99337
PNG
(US8497281, 115 | US9120769, 48 | US9663470, 48)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2cc[nH]c2c1
Show InChI InChI=1S/C22H22N2O/c25-22(17-8-7-16-11-12-23-20(16)14-17)24-13-3-6-19-18-5-2-1-4-15(18)9-10-21(19)24/h1-2,4-5,7-8,11-12,14,19,21,23H,3,6,9-10,13H2/t19?,21-/m0/s1
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n/an/a 514n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177632
PNG
(US9120769, 97 | US9663470, 97)
Show SMILES Brc1ccc2C[C@H]3C(CCCN3C(=O)c3ccc4[nH]cnc4c3)c2c1
Show InChI InChI=1S/C20H18BrN3O/c21-14-5-3-12-9-19-15(16(12)10-14)2-1-7-24(19)20(25)13-4-6-17-18(8-13)23-11-22-17/h3-6,8,10-11,15,19H,1-2,7,9H2,(H,22,23)/t15?,19-/m0/s1
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n/an/a 526n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99425
PNG
(US8497281, 203 | US9120769, 136 | US9663470, 136)
Show SMILES O=C(N1CCCC2[C@@H]1Cc1ccccc21)c1c[nH]c2ccccc12
Show InChI InChI=1S/C21H20N2O/c24-21(18-13-22-19-10-4-3-8-16(18)19)23-11-5-9-17-15-7-2-1-6-14(15)12-20(17)23/h1-4,6-8,10,13,17,20,22H,5,9,11-12H2/t17?,20-/m0/s1
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n/an/a 527n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM327801
PNG
(US9663470, 23 | cis-4-(1H-Benzoimidazole-5-carbony...)
Show SMILES COC(=O)c1cccc2CC[C@H]3C(CCCN3C(=O)c3ccc4[nH]cnc4c3)c12
Show InChI InChI=1S/C23H23N3O3/c1-29-23(28)17-5-2-4-14-8-10-20-16(21(14)17)6-3-11-26(20)22(27)15-7-9-18-19(12-15)25-13-24-18/h2,4-5,7,9,12-13,16,20H,3,6,8,10-11H2,1H3,(H,24,25)/t16?,20-/m0/s1
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n/an/a 551n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177581
PNG
(US9120769, 4 | US9663470, 4)
Show SMILES O=C(N1CCCC2[C@H]1CCc1ccccc21)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C21H21N3O/c25-21(15-7-9-18-19(12-15)23-13-22-18)24-11-3-6-17-16-5-2-1-4-14(16)8-10-20(17)24/h1-2,4-5,7,9,12-13,17,20H,3,6,8,10-11H2,(H,22,23)/t17?,20-/m1/s1
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n/an/a 573n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177665
PNG
(US9120769, 167 | US9663470, 167)
Show SMILES CS(=O)(=O)Nc1ccc2[C@H]3CCCN([C@H]3Cc2c1)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C21H22N4O3S/c1-29(27,28)24-15-5-6-16-14(9-15)11-20-17(16)3-2-8-25(20)21(26)13-4-7-18-19(10-13)23-12-22-18/h4-7,9-10,12,17,20,24H,2-3,8,11H2,1H3,(H,22,23)/t17-,20+/m1/s1
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n/an/a 573n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99424
PNG
(US8497281, 202 | US9120769, 135 | US9663470, 135)
Show SMILES O=C(N1CCCC2[C@@H]1Cc1ccccc21)c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C21H20N2O/c24-21(16-7-8-19-15(12-16)9-10-22-19)23-11-3-6-18-17-5-2-1-4-14(17)13-20(18)23/h1-2,4-5,7-10,12,18,20,22H,3,6,11,13H2/t18?,20-/m0/s1
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n/an/a 585n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99433
PNG
(US8497281, 211 | US9120769, 144 | US9663470, 144)
Show SMILES COc1cc(ccc1N)C(=O)N1CCCC2[C@@H]1Cc1ccccc21
Show InChI InChI=1S/C20H22N2O2/c1-24-19-12-14(8-9-17(19)21)20(23)22-10-4-7-16-15-6-3-2-5-13(15)11-18(16)22/h2-3,5-6,8-9,12,16,18H,4,7,10-11,21H2,1H3/t16?,18-/m0/s1
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n/an/a 609n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99355
PNG
(US8497281, 133 | US9120769, 66 | US9663470, 66)
Show SMILES CC1(C)C(=O)Nc2ccc(cc12)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C24H26N2O2/c1-24(2)19-14-16(9-11-20(19)25-23(24)28)22(27)26-13-5-8-18-17-7-4-3-6-15(17)10-12-21(18)26/h3-4,6-7,9,11,14,18,21H,5,8,10,12-13H2,1-2H3,(H,25,28)/t18?,21-/m0/s1
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n/an/a 631n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99412
PNG
(US8497281, 190 | US9120769, 123 | US9663470, 123)
Show SMILES O=C(N1CCCC2[C@@H]1Cc1ccccc21)c1ccc2cn[nH]c2c1
Show InChI InChI=1S/C20H19N3O/c24-20(14-7-8-15-12-21-22-18(15)10-14)23-9-3-6-17-16-5-2-1-4-13(16)11-19(17)23/h1-2,4-5,7-8,10,12,17,19H,3,6,9,11H2,(H,21,22)/t17?,19-/m0/s1
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n/an/a 644n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99368
PNG
(US8497281, 146 | US9120769, 79 | US9663470, 79)
Show SMILES Nc1ccc(cc1F)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C20H21FN2O/c21-17-12-14(7-9-18(17)22)20(24)23-11-3-6-16-15-5-2-1-4-13(15)8-10-19(16)23/h1-2,4-5,7,9,12,16,19H,3,6,8,10-11,22H2/t16?,19-/m0/s1
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n/an/a 650n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177607
PNG
(US9120769, 34 | US9663470, 34)
Show SMILES OCc1ccc2C3CCCN([C@H]3CCc2c1)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C22H23N3O2/c26-12-14-3-6-17-15(10-14)5-8-21-18(17)2-1-9-25(21)22(27)16-4-7-19-20(11-16)24-13-23-19/h3-4,6-7,10-11,13,18,21,26H,1-2,5,8-9,12H2,(H,23,24)/t18?,21-/m0/s1
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n/an/a 651n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177617
PNG
(US9120769, 72 | US9663470, 72)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2[nH]nnc2c1
Show InChI InChI=1S/C20H20N4O/c25-20(14-7-9-17-18(12-14)22-23-21-17)24-11-3-6-16-15-5-2-1-4-13(15)8-10-19(16)24/h1-2,4-5,7,9,12,16,19H,3,6,8,10-11H2,(H,21,22,23)/t16?,19-/m0/s1
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n/an/a 656n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99392
PNG
(US8497281, 170 | US9120769, 103 | US9663470, 103)
Show SMILES O=C(N1CCCC2[C@@H]1Cc1ccccc21)c1ccc2[nH]c(=O)sc2c1
Show InChI InChI=1S/C20H18N2O2S/c23-19(13-7-8-16-18(11-13)25-20(24)21-16)22-9-3-6-15-14-5-2-1-4-12(14)10-17(15)22/h1-2,4-5,7-8,11,15,17H,3,6,9-10H2,(H,21,24)/t15?,17-/m0/s1
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n/an/a 670n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177648
PNG
(US9120769, 150 | US9663470, 150)
Show SMILES Oc1ccc2C[C@H]3[C@H](CCCN3C(=O)c3ccc4[nH]cnc4c3)c2c1
Show InChI InChI=1S/C20H19N3O2/c24-14-5-3-12-9-19-15(16(12)10-14)2-1-7-23(19)20(25)13-4-6-17-18(8-13)22-11-21-17/h3-6,8,10-11,15,19,24H,1-2,7,9H2,(H,21,22)/t15-,19+/m1/s1
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n/an/a 674n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177606
PNG
(US9120769, 33 | US9663470, 33)
Show SMILES COC(=O)c1ccc2C3CCCN([C@H]3CCc2c1)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C23H23N3O3/c1-29-23(28)16-4-7-17-14(11-16)6-9-21-18(17)3-2-10-26(21)22(27)15-5-8-19-20(12-15)25-13-24-19/h4-5,7-8,11-13,18,21H,2-3,6,9-10H2,1H3,(H,24,25)/t18?,21-/m0/s1
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n/an/a 676n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99366
PNG
(US8497281, 144 | US9120769, 77 | US9663470, 77)
Show SMILES Cc1ccc(cc1N)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C21H24N2O/c1-14-8-9-16(13-19(14)22)21(24)23-12-4-7-18-17-6-3-2-5-15(17)10-11-20(18)23/h2-3,5-6,8-9,13,18,20H,4,7,10-12,22H2,1H3/t18?,20-/m0/s1
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n/an/a 685n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177624
PNG
(US9120769, 88 | US9663470, 88)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1cccc(C#N)c21)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C22H20N4O/c23-12-16-4-1-3-14-7-9-20-17(21(14)16)5-2-10-26(20)22(27)15-6-8-18-19(11-15)25-13-24-18/h1,3-4,6,8,11,13,17,20H,2,5,7,9-10H2,(H,24,25)/t17?,20-/m0/s1
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n/an/a 705n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177636
PNG
(US9120769, 101 | US9663470, 101)
Show SMILES CNC(=O)c1ccc2C3CCCN([C@H]3Cc2c1)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C22H22N4O2/c1-23-21(27)13-4-6-16-15(9-13)11-20-17(16)3-2-8-26(20)22(28)14-5-7-18-19(10-14)25-12-24-18/h4-7,9-10,12,17,20H,2-3,8,11H2,1H3,(H,23,27)(H,24,25)/t17?,20-/m0/s1
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n/an/a 712n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99356
PNG
(US8497281, 134 | US9120769, 67 | US9663470, 67)
Show SMILES Nc1ccc(cc1)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C20H22N2O/c21-16-10-7-15(8-11-16)20(23)22-13-3-6-18-17-5-2-1-4-14(17)9-12-19(18)22/h1-2,4-5,7-8,10-11,18-19H,3,6,9,12-13,21H2/t18?,19-/m0/s1
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n/an/a 722n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99401
PNG
(US8497281, 179 | US9120769, 112 | US9663470, 112)
Show SMILES Cc1cc2cc(ccc2[nH]1)C(=O)N1CCCC2[C@@H]1Cc1ccccc21
Show InChI InChI=1S/C22H22N2O/c1-14-11-17-12-16(8-9-20(17)23-14)22(25)24-10-4-7-19-18-6-3-2-5-15(18)13-21(19)24/h2-3,5-6,8-9,11-12,19,21,23H,4,7,10,13H2,1H3/t19?,21-/m0/s1
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n/an/a 724n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99434
PNG
(US8497281, 212 | US9120769, 145 | US9663470, 145)
Show SMILES Nc1ccc(cc1F)C(=O)N1CCCC2[C@@H]1Cc1ccccc21
Show InChI InChI=1S/C19H19FN2O/c20-16-10-13(7-8-17(16)21)19(23)22-9-3-6-15-14-5-2-1-4-12(14)11-18(15)22/h1-2,4-5,7-8,10,15,18H,3,6,9,11,21H2/t15?,18-/m0/s1
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n/an/a 777n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99350
PNG
(US8497281, 128 | US9120769, 61 | US9663470, 61)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C21H19N3O2/c25-20(14-7-9-17-18(12-14)23-21(26)22-17)24-11-3-6-16-15-5-2-1-4-13(15)8-10-19(16)24/h1-2,4-5,7,9,12,16,19H,3,6,8,10-11H2/t16?,19-/m0/s1
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n/an/a 821n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177605
PNG
(US9120769, 29 | US9663470, 29)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1cc(ccc21)-c1ccccc1)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C27H25N3O/c31-27(21-9-12-24-25(16-21)29-17-28-24)30-14-4-7-23-22-11-8-19(18-5-2-1-3-6-18)15-20(22)10-13-26(23)30/h1-3,5-6,8-9,11-12,15-17,23,26H,4,7,10,13-14H2,(H,28,29)/t23?,26-/m0/s1
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n/an/a 831n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99393
PNG
(US8497281, 171 | US9120769, 104 | US9663470, 104)
Show SMILES O=C(N1CCCC2[C@@H]1Cc1ccccc21)c1ccc2nccn2c1
Show InChI InChI=1S/C20H19N3O/c24-20(15-7-8-19-21-9-11-22(19)13-15)23-10-3-6-17-16-5-2-1-4-14(16)12-18(17)23/h1-2,4-5,7-9,11,13,17-18H,3,6,10,12H2/t17?,18-/m0/s1
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n/an/a 847n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177635
PNG
(US9120769, 100 | US9663470, 100)
Show SMILES NC(=O)c1ccc2C[C@H]3C(CCCN3C(=O)c3ccc4[nH]cnc4c3)c2c1
Show InChI InChI=1S/C21H20N4O2/c22-20(26)13-4-3-12-10-19-15(16(12)8-13)2-1-7-25(19)21(27)14-5-6-17-18(9-14)24-11-23-17/h3-6,8-9,11,15,19H,1-2,7,10H2,(H2,22,26)(H,23,24)/t15?,19-/m0/s1
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n/an/a 850n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99422
PNG
(US8497281, 200 | US9120769, 133 | US9663470, 133)
Show SMILES Nc1ccc(cc1)C(=O)N1CCCC2[C@@H]1Cc1ccccc21
Show InChI InChI=1S/C19H20N2O/c20-15-9-7-13(8-10-15)19(22)21-11-3-6-17-16-5-2-1-4-14(16)12-18(17)21/h1-2,4-5,7-10,17-18H,3,6,11-12,20H2/t17?,18-/m0/s1
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n/an/a 854n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99294
PNG
(US8497281, 72 | US9120769, 5 | US9663470, 5)
Show SMILES NC(=O)c1ccc(cc1)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C21H22N2O2/c22-20(24)15-7-9-16(10-8-15)21(25)23-13-3-6-18-17-5-2-1-4-14(17)11-12-19(18)23/h1-2,4-5,7-10,18-19H,3,6,11-13H2,(H2,22,24)/t18?,19-/m0/s1
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n/an/a 861n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177628
PNG
(US9120769, 92 | US9663470, 92)
Show SMILES Cc1ccc(Oc2cccc3CC[C@H]4C(CCCN4C(=O)c4ccc5[nH]cnc5c4)c23)nn1
Show InChI InChI=1S/C26H25N5O2/c1-16-7-12-24(30-29-16)33-23-6-2-4-17-9-11-22-19(25(17)23)5-3-13-31(22)26(32)18-8-10-20-21(14-18)28-15-27-20/h2,4,6-8,10,12,14-15,19,22H,3,5,9,11,13H2,1H3,(H,27,28)/t19?,22-/m0/s1
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n/an/a 884n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99360
PNG
(US8497281, 138 | US9120769, 71 | US9663470, 71)
Show SMILES Oc1c(Cl)cc(cc1Cl)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C20H19Cl2NO2/c21-16-10-13(11-17(22)19(16)24)20(25)23-9-3-6-15-14-5-2-1-4-12(14)7-8-18(15)23/h1-2,4-5,10-11,15,18,24H,3,6-9H2/t15?,18-/m0/s1
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n/an/a 915n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99365
PNG
(US8497281, 143 | US9120769, 76 | US9663470, 76)
Show SMILES Nc1cc(ccc1Cl)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C20H21ClN2O/c21-17-9-7-14(12-18(17)22)20(24)23-11-3-6-16-15-5-2-1-4-13(15)8-10-19(16)23/h1-2,4-5,7,9,12,16,19H,3,6,8,10-11,22H2/t16?,19-/m0/s1
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n/an/a 933n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99351
PNG
(US8497281, 129 | US9120769, 62 | US9663470, 62)
Show SMILES Cn1cnc2ccc(cc12)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C22H23N3O/c1-24-14-23-19-10-8-16(13-21(19)24)22(26)25-12-4-7-18-17-6-3-2-5-15(17)9-11-20(18)25/h2-3,5-6,8,10,13-14,18,20H,4,7,9,11-12H2,1H3/t18?,20-/m0/s1
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n/an/a 940n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM327810
PNG
(US9663470, 32 | cis-10-(6-Methyl-pyridazin-3-yloxy...)
Show SMILES Cc1ccc(Oc2cccc3CC[C@H]4C(CCCN4C(=O)OC(C)(C)C)c23)nn1
Show InChI InChI=1S/C23H29N3O3/c1-15-10-13-20(25-24-15)28-19-9-5-7-16-11-12-18-17(21(16)19)8-6-14-26(18)22(27)29-23(2,3)4/h5,7,9-10,13,17-18H,6,8,11-12,14H2,1-4H3/t17?,18-/m0/s1
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n/an/a 954n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99346
PNG
(US8497281, 124 | US9120769, 57 | US9663470, 57)
Show SMILES Nc1nc2ccc(cc2[nH]1)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C21H22N4O/c22-21-23-17-9-7-14(12-18(17)24-21)20(26)25-11-3-6-16-15-5-2-1-4-13(15)8-10-19(16)25/h1-2,4-5,7,9,12,16,19H,3,6,8,10-11H2,(H3,22,23,24)/t16?,19-/m0/s1
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n/an/a 969n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99342
PNG
(US8497281, 120 | US9120769, 53 | US9663470, 53)
Show SMILES COc1cccc2C3CCCN([C@H]3CCc12)C(=O)c1cn(C)c2ccccc12
Show InChI InChI=1S/C24H26N2O2/c1-25-15-20(18-7-3-4-10-21(18)25)24(27)26-14-6-9-17-16-8-5-11-23(28-2)19(16)12-13-22(17)26/h3-5,7-8,10-11,15,17,22H,6,9,12-14H2,1-2H3/t17?,22-/m0/s1
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n/an/a 979n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99431
PNG
(US8497281, 209 | US9120769, 142 | US9663470, 142)
Show SMILES Nc1cc(ccc1Cl)C(=O)N1CCCC2[C@@H]1Cc1ccccc21
Show InChI InChI=1S/C19H19ClN2O/c20-16-8-7-13(10-17(16)21)19(23)22-9-3-6-15-14-5-2-1-4-12(14)11-18(15)22/h1-2,4-5,7-8,10,15,18H,3,6,9,11,21H2/t15?,18-/m0/s1
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n/an/a 996n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177656
PNG
(US9120769, 158 | US9663470, 158)
Show SMILES O=C(N1CCC[C@H]2[C@@H]1Cc1ccc(cc21)-c1ccccc1)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C26H23N3O/c30-26(20-10-11-23-24(14-20)28-16-27-23)29-12-4-7-21-22-13-18(17-5-2-1-3-6-17)8-9-19(22)15-25(21)29/h1-3,5-6,8-11,13-14,16,21,25H,4,7,12,15H2,(H,27,28)/t21-,25+/m1/s1
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n/an/a 998n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177594
PNG
(US9120769, 18 | US9663470, 18)
Show SMILES Oc1cccc2CC[C@@H]3C(CCCN3C(=O)c3ccc4[nH]cnc4c3)c12
Show InChI InChI=1S/C21H21N3O2/c25-19-5-1-3-13-7-9-18-15(20(13)19)4-2-10-24(18)21(26)14-6-8-16-17(11-14)23-12-22-16/h1,3,5-6,8,11-12,15,18,25H,2,4,7,9-10H2,(H,22,23)/t15?,18-/m1/s1
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n/an/a 1.03E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177631
PNG
(US9120769, 95 | US9663470, 95)
Show SMILES O=C(N1CCC[C@@H]2[C@H]1Cc1ccccc21)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C20H19N3O/c24-20(14-7-8-17-18(10-14)22-12-21-17)23-9-3-6-16-15-5-2-1-4-13(15)11-19(16)23/h1-2,4-5,7-8,10,12,16,19H,3,6,9,11H2,(H,21,22)/t16-,19+/m0/s1
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n/an/a 1.03E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177616
PNG
(US9120769, 60 | US9663470, 60)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2nc[nH]c2n1
Show InChI InChI=1S/C20H20N4O/c25-20(17-9-8-16-19(23-17)22-12-21-16)24-11-3-6-15-14-5-2-1-4-13(14)7-10-18(15)24/h1-2,4-5,8-9,12,15,18H,3,6-7,10-11H2,(H,21,22,23)/t15?,18-/m0/s1
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n/an/a 1.05E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177644
PNG
(US9120769, 138 | US9663470, 138)
Show SMILES O=C(N1CCCC2[C@@H]1Cc1ccccc21)c1ccc2[nH]nnc2c1
Show InChI InChI=1S/C19H18N4O/c24-19(13-7-8-16-17(10-13)21-22-20-16)23-9-3-6-15-14-5-2-1-4-12(14)11-18(15)23/h1-2,4-5,7-8,10,15,18H,3,6,9,11H2,(H,20,21,22)/t15?,18-/m0/s1
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n/an/a 1.05E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99334
PNG
(US8497281, 112 | US9120769, 45 | US9663470, 45)
Show SMILES COc1ccc(cc1N)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C21H24N2O2/c1-25-20-11-9-15(13-18(20)22)21(24)23-12-4-7-17-16-6-3-2-5-14(16)8-10-19(17)23/h2-3,5-6,9,11,13,17,19H,4,7-8,10,12,22H2,1H3/t17?,19-/m0/s1
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n/an/a 1.07E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99407
PNG
(US8497281, 185 | US9120769, 118 | US9663470, 118)
Show SMILES Cn1nnc2cc(ccc12)C(=O)N1CCCC2[C@@H]1Cc1ccccc21
Show InChI InChI=1S/C20H20N4O/c1-23-18-9-8-14(11-17(18)21-22-23)20(25)24-10-4-7-16-15-6-3-2-5-13(15)12-19(16)24/h2-3,5-6,8-9,11,16,19H,4,7,10,12H2,1H3/t16?,19-/m0/s1
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n/an/a 1.07E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99385
PNG
(US8497281, 163 | US9120769, 96 | US9663470, 96)
Show SMILES NC(=O)c1ccc(cc1)C(=O)N1CCCC2[C@@H]1Cc1ccccc21
Show InChI InChI=1S/C20H20N2O2/c21-19(23)13-7-9-14(10-8-13)20(24)22-11-3-6-17-16-5-2-1-4-15(16)12-18(17)22/h1-2,4-5,7-10,17-18H,3,6,11-12H2,(H2,21,23)/t17?,18-/m0/s1
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n/an/a 1.11E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99347
PNG
(US8497281, 125 | US9120769, 58 | US9663470, 58)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2ncsc2c1
Show InChI InChI=1S/C21H20N2OS/c24-21(15-7-9-18-20(12-15)25-13-22-18)23-11-3-6-17-16-5-2-1-4-14(16)8-10-19(17)23/h1-2,4-5,7,9,12-13,17,19H,3,6,8,10-11H2/t17?,19-/m0/s1
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n/an/a 1.11E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99426
PNG
(US8497281, 204 | US9120769, 137 | US9663470, 137)
Show SMILES Oc1c(Cl)cc(cc1Cl)C(=O)N1CCCC2[C@@H]1Cc1ccccc21
Show InChI InChI=1S/C19H17Cl2NO2/c20-15-8-12(9-16(21)18(15)23)19(24)22-7-3-6-14-13-5-2-1-4-11(13)10-17(14)22/h1-2,4-5,8-9,14,17,23H,3,6-7,10H2/t14?,17-/m0/s1
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n/an/a 1.12E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177614
PNG
(US9120769, 41 | US9663470, 41)
Show SMILES CC(C)(O)c1ccc2C3CCCN([C@H]3CCc2c1)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C24H27N3O2/c1-24(2,29)17-7-8-18-15(12-17)6-10-22-19(18)4-3-11-27(22)23(28)16-5-9-20-21(13-16)26-14-25-20/h5,7-9,12-14,19,22,29H,3-4,6,10-11H2,1-2H3,(H,25,26)/t19?,22-/m0/s1
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n/an/a 1.12E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99416
PNG
(US8497281, 194 | US9120769, 127 | US9663470, 127)
Show SMILES O=C(N1CCCC2[C@@H]1Cc1ccccc21)c1cnc2nc[nH]c2c1
Show InChI InChI=1S/C19H18N4O/c24-19(13-8-16-18(20-10-13)22-11-21-16)23-7-3-6-15-14-5-2-1-4-12(14)9-17(15)23/h1-2,4-5,8,10-11,15,17H,3,6-7,9H2,(H,20,21,22)/t15?,17-/m0/s1
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n/an/a 1.13E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177597
PNG
(US9120769, 21 | US9663470, 21)
Show SMILES Fc1cc(F)c2CC[C@@H]3C(CCCN3C(=O)c3ccc4[nH]cnc4c3)c2c1
Show InChI InChI=1S/C21H19F2N3O/c22-13-9-16-14(17(23)10-13)4-6-20-15(16)2-1-7-26(20)21(27)12-3-5-18-19(8-12)25-11-24-18/h3,5,8-11,15,20H,1-2,4,6-7H2,(H,24,25)/t15?,20-/m1/s1
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n/an/a 1.13E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99419
PNG
(US8497281, 197 | US9120769, 130 | US9663470, 130)
Show SMILES Nc1cc(ccc1F)C(=O)N1CCCC2[C@@H]1Cc1ccccc21
Show InChI InChI=1S/C19H19FN2O/c20-16-8-7-13(10-17(16)21)19(23)22-9-3-6-15-14-5-2-1-4-12(14)11-18(15)22/h1-2,4-5,7-8,10,15,18H,3,6,9,11,21H2/t15?,18-/m0/s1
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n/an/a 1.14E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177655
PNG
(US9120769, 157 | US9663470, 157)
Show SMILES CC(C)(O)c1ccc2C[C@H]3[C@H](CCCN3C(=O)c3ccc4[nH]cnc4c3)c2c1
Show InChI InChI=1S/C23H25N3O2/c1-23(2,28)16-7-5-14-11-21-17(18(14)12-16)4-3-9-26(21)22(27)15-6-8-19-20(10-15)25-13-24-19/h5-8,10,12-13,17,21,28H,3-4,9,11H2,1-2H3,(H,24,25)/t17-,21+/m1/s1
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n/an/a 1.16E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177633
PNG
(US9120769, 98 | US9663470, 98)
Show SMILES OC(=O)c1ccc2C[C@H]3C(CCCN3C(=O)c3ccc4[nH]cnc4c3)c2c1
Show InChI InChI=1S/C21H19N3O3/c25-20(13-5-6-17-18(9-13)23-11-22-17)24-7-1-2-15-16-8-14(21(26)27)4-3-12(16)10-19(15)24/h3-6,8-9,11,15,19H,1-2,7,10H2,(H,22,23)(H,26,27)/t15?,19-/m0/s1
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n/an/a 1.25E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177662
PNG
(US9120769, 164 | US9663470, 164)
Show SMILES O=C(N1CCC[C@H]2[C@@H]1Cc1ccc(cc21)C1CCOCC1)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C25H27N3O2/c29-25(19-5-6-22-23(13-19)27-15-26-22)28-9-1-2-20-21-12-17(16-7-10-30-11-8-16)3-4-18(21)14-24(20)28/h3-6,12-13,15-16,20,24H,1-2,7-11,14H2,(H,26,27)/t20-,24+/m1/s1
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n/an/a 1.32E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177625
PNG
(US9120769, 89 | US9663470, 89)
Show SMILES COc1ccc(Oc2ccc3C4CCCN([C@H]4CCc3c2)C(=O)c2ccc3[nH]cnc3c2)cc1
Show InChI InChI=1S/C28H27N3O3/c1-33-20-6-8-21(9-7-20)34-22-10-11-23-18(15-22)5-13-27-24(23)3-2-14-31(27)28(32)19-4-12-25-26(16-19)30-17-29-25/h4,6-12,15-17,24,27H,2-3,5,13-14H2,1H3,(H,29,30)/t24?,27-/m0/s1
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n/an/a 1.32E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177643
PNG
(US9120769, 124 | US9663470, 124)
Show SMILES Nc1nc2cc(ccc2[nH]1)C(=O)N1CCCC2[C@@H]1Cc1ccccc21
Show InChI InChI=1S/C20H20N4O/c21-20-22-16-8-7-13(10-17(16)23-20)19(25)24-9-3-6-15-14-5-2-1-4-12(14)11-18(15)24/h1-2,4-5,7-8,10,15,18H,3,6,9,11H2,(H3,21,22,23)/t15?,18-/m0/s1
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n/an/a 1.32E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99352
PNG
(US8497281, 130 | US9120769, 63 | US9663470, 63)
Show SMILES Nc1cc(ccc1F)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C20H21FN2O/c21-17-9-7-14(12-18(17)22)20(24)23-11-3-6-16-15-5-2-1-4-13(15)8-10-19(16)23/h1-2,4-5,7,9,12,16,19H,3,6,8,10-11,22H2/t16?,19-/m0/s1
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n/an/a 1.34E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177618
PNG
(US9120769, 82 | US9663470, 82)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1cc(Cc3ccccc3)ccc21)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C28H27N3O/c32-28(22-9-12-25-26(17-22)30-18-29-25)31-14-4-7-24-23-11-8-20(15-19-5-2-1-3-6-19)16-21(23)10-13-27(24)31/h1-3,5-6,8-9,11-12,16-18,24,27H,4,7,10,13-15H2,(H,29,30)/t24?,27-/m0/s1
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n/an/a 1.34E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99400
PNG
(US8497281, 178 | US9120769, 111 | US9663470, 111)
Show SMILES COc1ccc(cc1N)C(=O)N1CCCC2[C@@H]1Cc1ccccc21
Show InChI InChI=1S/C20H22N2O2/c1-24-19-9-8-14(11-17(19)21)20(23)22-10-4-7-16-15-6-3-2-5-13(15)12-18(16)22/h2-3,5-6,8-9,11,16,18H,4,7,10,12,21H2,1H3/t16?,18-/m0/s1
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n/an/a 1.38E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM327781
PNG
(US9663470, 3 | cis-7-Methoxy-1,2,3,4,4a,5,6,10b-oc...)
Show SMILES COc1cccc2C3CCCN[C@H]3CCc12
Show InChI InChI=1S/C14H19NO/c1-16-14-6-2-4-10-11-5-3-9-15-13(11)8-7-12(10)14/h2,4,6,11,13,15H,3,5,7-9H2,1H3/t11?,13-/m0/s1
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n/an/a 1.38E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99432
PNG
(US8497281, 210 | US9120769, 143 | US9663470, 143)
Show SMILES Cc1ccc(cc1N)C(=O)N1CCCC2[C@@H]1Cc1ccccc21
Show InChI InChI=1S/C20H22N2O/c1-13-8-9-15(11-18(13)21)20(23)22-10-4-7-17-16-6-3-2-5-14(16)12-19(17)22/h2-3,5-6,8-9,11,17,19H,4,7,10,12,21H2,1H3/t17?,19-/m0/s1
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n/an/a 1.41E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177592
PNG
(US9120769, 16 | US9663470, 16)
Show SMILES Oc1ccc2CC[C@H]3C(CCCN3C(=O)c3ccc4[nH]cnc4c3)c2c1
Show InChI InChI=1S/C21H21N3O2/c25-15-6-3-13-5-8-20-16(17(13)11-15)2-1-9-24(20)21(26)14-4-7-18-19(10-14)23-12-22-18/h3-4,6-7,10-12,16,20,25H,1-2,5,8-9H2,(H,22,23)/t16?,20-/m0/s1
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n/an/a 1.41E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99398
PNG
(US8497281, 176 | US9120769, 109 | US9663470, 109)
Show SMILES Nc1nc2ccc(cc2s1)C(=O)N1CCCC2[C@@H]1Cc1ccccc21
Show InChI InChI=1S/C20H19N3OS/c21-20-22-16-8-7-13(11-18(16)25-20)19(24)23-9-3-6-15-14-5-2-1-4-12(14)10-17(15)23/h1-2,4-5,7-8,11,15,17H,3,6,9-10H2,(H2,21,22)/t15?,17-/m0/s1
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n/an/a 1.46E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99338
PNG
(US8497281, 116 | US9120769, 49 | US9663470, 49)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2NC(=O)Cc2c1
Show InChI InChI=1S/C22H22N2O2/c25-21-13-16-12-15(7-9-19(16)23-21)22(26)24-11-3-6-18-17-5-2-1-4-14(17)8-10-20(18)24/h1-2,4-5,7,9,12,18,20H,3,6,8,10-11,13H2,(H,23,25)/t18?,20-/m0/s1
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n/an/a 1.47E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177611
PNG
(US9120769, 38 | US9663470, 38)
Show SMILES CN(C)C(=O)c1ccc2C3CCCN([C@H]3CCc2c1)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C24H26N4O2/c1-27(2)23(29)16-5-8-18-15(12-16)7-10-22-19(18)4-3-11-28(22)24(30)17-6-9-20-21(13-17)26-14-25-20/h5-6,8-9,12-14,19,22H,3-4,7,10-11H2,1-2H3,(H,25,26)/t19?,22-/m0/s1
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n/an/a 1.47E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99418
PNG
(US8497281, 196 | US9120769, 129 | US9663470, 129)
Show SMILES Cn1cnc2ccc(cc12)C(=O)N1CCCC2[C@@H]1Cc1ccccc21
Show InChI InChI=1S/C21H21N3O/c1-23-13-22-18-9-8-15(12-20(18)23)21(25)24-10-4-7-17-16-6-3-2-5-14(16)11-19(17)24/h2-3,5-6,8-9,12-13,17,19H,4,7,10-11H2,1H3/t17?,19-/m0/s1
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n/an/a 1.49E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM327804
PNG
(US9663470, 26 | cis-4-(1H-Benzoimidazole-5-carbony...)
Show SMILES OC(=O)c1cccc2CC[C@H]3C(CCCN3C(=O)c3ccc4[nH]cnc4c3)c12
Show InChI InChI=1S/C22H21N3O3/c26-21(14-6-8-17-18(11-14)24-12-23-17)25-10-2-5-15-19(25)9-7-13-3-1-4-16(20(13)15)22(27)28/h1,3-4,6,8,11-12,15,19H,2,5,7,9-10H2,(H,23,24)(H,27,28)/t15?,19-/m0/s1
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n/an/a 1.51E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177612
PNG
(US9120769, 39 | US9663470, 39)
Show SMILES O=C(N1CCCC1)c1ccc2C3CCCN([C@H]3CCc2c1)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C26H28N4O2/c31-25(29-11-1-2-12-29)18-5-8-20-17(14-18)7-10-24-21(20)4-3-13-30(24)26(32)19-6-9-22-23(15-19)28-16-27-22/h5-6,8-9,14-16,21,24H,1-4,7,10-13H2,(H,27,28)/t21?,24-/m0/s1
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n/an/a 1.52E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99399
PNG
(US8497281, 177 | US9120769, 110 | US9663470, 110)
Show SMILES Cc1ccc(cc1O)C(=O)N1CCCC2[C@@H]1Cc1ccccc21
Show InChI InChI=1S/C20H21NO2/c1-13-8-9-15(12-19(13)22)20(23)21-10-4-7-17-16-6-3-2-5-14(16)11-18(17)21/h2-3,5-6,8-9,12,17-18,22H,4,7,10-11H2,1H3/t17?,18-/m0/s1
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n/an/a 1.56E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99341
PNG
(US8497281, 119 | US9120769, 52 | US9663470, 52)
Show SMILES Cn1nnc2cc(ccc12)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C21H22N4O/c1-24-20-11-9-15(13-18(20)22-23-24)21(26)25-12-4-7-17-16-6-3-2-5-14(16)8-10-19(17)25/h2-3,5-6,9,11,13,17,19H,4,7-8,10,12H2,1H3/t17?,19-/m0/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177591
PNG
(US9120769, 15 | US9663470, 15)
Show SMILES COc1ccc2CC[C@@H]3C(CCCN3C(=O)c3ccc4[nH]cnc4c3)c2c1
Show InChI InChI=1S/C22H23N3O2/c1-27-16-7-4-14-6-9-21-17(18(14)12-16)3-2-10-25(21)22(26)15-5-8-19-20(11-15)24-13-23-19/h4-5,7-8,11-13,17,21H,2-3,6,9-10H2,1H3,(H,23,24)/t17?,21-/m1/s1
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n/an/a 1.62E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99429
PNG
(US8497281, 207 | US9120769, 140 | US9663470, 140)
Show SMILES COc1ccc(cc1O)C(=O)N1CCCC2[C@@H]1Cc1ccccc21
Show InChI InChI=1S/C20H21NO3/c1-24-19-9-8-14(12-18(19)22)20(23)21-10-4-7-16-15-6-3-2-5-13(15)11-17(16)21/h2-3,5-6,8-9,12,16-17,22H,4,7,10-11H2,1H3/t16?,17-/m0/s1
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n/an/a 1.62E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177621
PNG
(US9120769, 85 | US9663470, 85)
Show SMILES COc1ccc(Cc2cccc3CC[C@H]4C(CCCN4C(=O)c4ccc5[nH]cnc5c4)c23)cc1
Show InChI InChI=1S/C29H29N3O2/c1-34-23-11-7-19(8-12-23)16-21-5-2-4-20-10-14-27-24(28(20)21)6-3-15-32(27)29(33)22-9-13-25-26(17-22)31-18-30-25/h2,4-5,7-9,11-13,17-18,24,27H,3,6,10,14-16H2,1H3,(H,30,31)/t24?,27-/m0/s1
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n/an/a 1.63E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99332
PNG
(US8497281, 110 | US9120769, 43 | US9663470, 43)
Show SMILES Nc1nc2ccc(cc2s1)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C21H21N3OS/c22-21-23-17-9-7-14(12-19(17)26-21)20(25)24-11-3-6-16-15-5-2-1-4-13(15)8-10-18(16)24/h1-2,4-5,7,9,12,16,18H,3,6,8,10-11H2,(H2,22,23)/t16?,18-/m0/s1
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n/an/a 1.63E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99406
PNG
(US8497281, 184 | US9120769, 117 | US9663470, 117)
Show SMILES Cn1cnc2cc(ccc12)C(=O)N1CCCC2[C@@H]1Cc1ccccc21
Show InChI InChI=1S/C21H21N3O/c1-23-13-22-18-11-15(8-9-19(18)23)21(25)24-10-4-7-17-16-6-3-2-5-14(16)12-20(17)24/h2-3,5-6,8-9,11,13,17,20H,4,7,10,12H2,1H3/t17?,20-/m0/s1
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n/an/a 1.65E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99370
PNG
(US8497281, 148 | US9120769, 81 | US9663470, 81)
Show SMILES Cn1cc(C(=O)N2CCCC3[C@@H]2CCc2c(O)cccc32)c2ccccc12
Show InChI InChI=1S/C23H24N2O2/c1-24-14-19(17-6-2-3-9-20(17)24)23(27)25-13-5-8-16-15-7-4-10-22(26)18(15)11-12-21(16)25/h2-4,6-7,9-10,14,16,21,26H,5,8,11-13H2,1H3/t16?,21-/m0/s1
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n/an/a 1.73E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99436
PNG
(US8497281, 147 | US9120769, 147 | US9663470, 147)
Show SMILES O=C(N1CCCC2[C@@H]1Cc1ccccc21)c1ccc2[nH]c(=O)cnc2c1
Show InChI InChI=1S/C21H19N3O2/c25-20-12-22-18-10-14(7-8-17(18)23-20)21(26)24-9-3-6-16-15-5-2-1-4-13(15)11-19(16)24/h1-2,4-5,7-8,10,12,16,19H,3,6,9,11H2,(H,23,25)/t16?,19-/m0/s1
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n/an/a 1.74E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99415
PNG
(US8497281, 126 | US9120769, 126 | US9663470, 126)
Show SMILES Oc1cc(ccc1Cl)C(=O)N1CCCC2[C@@H]1Cc1ccccc21
Show InChI InChI=1S/C19H18ClNO2/c20-16-8-7-13(11-18(16)22)19(23)21-9-3-6-15-14-5-2-1-4-12(14)10-17(15)21/h1-2,4-5,7-8,11,15,17,22H,3,6,9-10H2/t15?,17-/m0/s1
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n/an/a 1.76E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177657
PNG
(US9120769, 159 | US9663470, 159)
Show SMILES O=C(N1CCC[C@H]2[C@@H]1Cc1ccc(cc21)C#Cc1ccccc1)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C28H23N3O/c32-28(22-12-13-25-26(16-22)30-18-29-25)31-14-4-7-23-24-15-20(10-11-21(24)17-27(23)31)9-8-19-5-2-1-3-6-19/h1-3,5-6,10-13,15-16,18,23,27H,4,7,14,17H2,(H,29,30)/t23-,27+/m1/s1
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n/an/a 1.79E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177600
PNG
(US9120769, 24 | US9663470, 24)
Show SMILES Oc1ccc2C3CCCN([C@@H]3CCc2c1)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C21H21N3O2/c25-15-5-6-16-13(10-15)4-8-20-17(16)2-1-9-24(20)21(26)14-3-7-18-19(11-14)23-12-22-18/h3,5-7,10-12,17,20,25H,1-2,4,8-9H2,(H,22,23)/t17?,20-/m1/s1
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n/an/a 1.79E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99405
PNG
(US8497281, 116 | US9120769, 116 | US9663470, 116)
Show SMILES O=C(N1CCCC2[C@@H]1Cc1ccccc21)c1ccc2CC(=O)Nc2c1
Show InChI InChI=1S/C21H20N2O2/c24-20-12-14-7-8-15(10-18(14)22-20)21(25)23-9-3-6-17-16-5-2-1-4-13(16)11-19(17)23/h1-2,4-5,7-8,10,17,19H,3,6,9,11-12H2,(H,22,24)/t17?,19-/m0/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177595
PNG
(US9120769, 19 | US9663470, 19)
Show SMILES Oc1cccc2C3CCCN([C@@H]3CCc12)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C21H21N3O2/c25-20-5-1-3-14-15-4-2-10-24(19(15)9-7-16(14)20)21(26)13-6-8-17-18(11-13)23-12-22-17/h1,3,5-6,8,11-12,15,19,25H,2,4,7,9-10H2,(H,22,23)/t15?,19-/m1/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99417
PNG
(US8497281, 128 | US9120769, 128 | US9663470, 128)
Show SMILES O=C(N1CCCC2[C@@H]1Cc1ccccc21)c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C20H17N3O2/c24-19(13-7-8-16-17(10-13)22-20(25)21-16)23-9-3-6-15-14-5-2-1-4-12(14)11-18(15)23/h1-2,4-5,7-8,10,15,18H,3,6,9,11H2/t15?,18-/m0/s1
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n/an/a 1.92E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99363
PNG
(US8497281, 74 | US9120769, 74 | US9663470, 74)
Show SMILES COc1ccc(cc1O)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C21H23NO3/c1-25-20-11-9-15(13-19(20)23)21(24)22-12-4-7-17-16-6-3-2-5-14(16)8-10-18(17)22/h2-3,5-6,9,11,13,17-18,23H,4,7-8,10,12H2,1H3/t17?,18-/m0/s1
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n/an/a 1.96E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99369
PNG
(US8497281, 80 | US9120769, 80 | US9663470, 80)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2[nH]c(=O)cnc2c1
Show InChI InChI=1S/C22H21N3O2/c26-21-13-23-19-12-15(7-9-18(19)24-21)22(27)25-11-3-6-17-16-5-2-1-4-14(16)8-10-20(17)25/h1-2,4-5,7,9,12-13,17,20H,3,6,8,10-11H2,(H,24,26)/t17?,20-/m0/s1
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n/an/a 1.97E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177619
PNG
(US9120769, 83 | US9663470, 83)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1cc(CC3CCCCC3)ccc21)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C28H33N3O/c32-28(22-9-12-25-26(17-22)30-18-29-25)31-14-4-7-24-23-11-8-20(15-19-5-2-1-3-6-19)16-21(23)10-13-27(24)31/h8-9,11-12,16-19,24,27H,1-7,10,13-15H2,(H,29,30)/t24?,27-/m0/s1
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n/an/a 2.06E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177620
PNG
(US9120769, 84 | US9663470, 84)
Show SMILES OCc1cccc2CC[C@H]3C(CCCN3C(=O)c3ccc4[nH]cnc4c3)c12
Show InChI InChI=1S/C22H23N3O2/c26-12-16-4-1-3-14-7-9-20-17(21(14)16)5-2-10-25(20)22(27)15-6-8-18-19(11-15)24-13-23-18/h1,3-4,6,8,11,13,17,20,26H,2,5,7,9-10,12H2,(H,23,24)/t17?,20-/m0/s1
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n/an/a 2.07E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99404
PNG
(US8497281, 115 | US9120769, 115 | US9663470, 115)
Show SMILES O=C(N1CCCC2[C@@H]1Cc1ccccc21)c1ccc2NC(=O)Cc2c1
Show InChI InChI=1S/C21H20N2O2/c24-20-12-15-10-14(7-8-18(15)22-20)21(25)23-9-3-6-17-16-5-2-1-4-13(16)11-19(17)23/h1-2,4-5,7-8,10,17,19H,3,6,9,11-12H2,(H,22,24)/t17?,19-/m0/s1
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n/an/a 2.08E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99348
PNG
(US8497281, 59 | US9120769, 59 | US9663470, 59)
Show SMILES Oc1cc(ccc1Cl)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C20H20ClNO2/c21-17-9-7-14(12-19(17)23)20(24)22-11-3-6-16-15-5-2-1-4-13(15)8-10-18(16)22/h1-2,4-5,7,9,12,16,18,23H,3,6,8,10-11H2/t16?,18-/m0/s1
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n/an/a 2.10E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177593
PNG
(US9120769, 17 | US9663470, 17)
Show SMILES Oc1ccc2CC[C@@H]3C(CCCN3C(=O)c3ccc4[nH]cnc4c3)c2c1
Show InChI InChI=1S/C21H21N3O2/c25-15-6-3-13-5-8-20-16(17(13)11-15)2-1-9-24(20)21(26)14-4-7-18-19(10-14)23-12-22-18/h3-4,6-7,10-12,16,20,25H,1-2,5,8-9H2,(H,22,23)/t16?,20-/m1/s1
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n/an/a 2.11E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177622
PNG
(US9120769, 86 | US9663470, 86)
Show SMILES CC1(C)C[C@H]2C(CCCN2C(=O)c2ccc3[nH]cnc3c2)c2ccccc12
Show InChI InChI=1S/C23H25N3O/c1-23(2)13-21-17(16-6-3-4-8-18(16)23)7-5-11-26(21)22(27)15-9-10-19-20(12-15)25-14-24-19/h3-4,6,8-10,12,14,17,21H,5,7,11,13H2,1-2H3,(H,24,25)/t17?,21-/m0/s1
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n/an/a 2.11E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177613
PNG
(US9120769, 40 | US9663470, 40)
Show SMILES O=C(N1CCOCC1)c1ccc2C3CCCN([C@H]3CCc2c1)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C26H28N4O3/c31-25(29-10-12-33-13-11-29)18-3-6-20-17(14-18)5-8-24-21(20)2-1-9-30(24)26(32)19-4-7-22-23(15-19)28-16-27-22/h3-4,6-7,14-16,21,24H,1-2,5,8-13H2,(H,27,28)/t21?,24-/m0/s1
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n/an/a 2.15E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99333
PNG
(US8497281, 44 | US9120769, 44 | US9663470, 44)
Show SMILES Cc1ccc(cc1O)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C21H23NO2/c1-14-8-9-16(13-20(14)23)21(24)22-12-4-7-18-17-6-3-2-5-15(17)10-11-19(18)22/h2-3,5-6,8-9,13,18-19,23H,4,7,10-12H2,1H3/t18?,19-/m0/s1
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n/an/a 2.15E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99336
PNG
(US8497281, 47 | US9120769, 47 | US9663470, 47)
Show SMILES Cn1c2ccc(cc2[nH]c1=O)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C22H23N3O2/c1-24-20-11-9-15(13-18(20)23-22(24)27)21(26)25-12-4-7-17-16-6-3-2-5-14(16)8-10-19(17)25/h2-3,5-6,9,11,13,17,19H,4,7-8,10,12H2,1H3,(H,23,27)/t17?,19-/m0/s1
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n/an/a 2.16E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99319
PNG
(US8497281, 127 | US8497281, 30 | US9120769, 30 | U...)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2[nH]cnc2n1
Show InChI InChI=1S/C20H20N4O/c25-20(17-9-8-16-19(23-17)22-12-21-16)24-11-3-6-15-14-5-2-1-4-13(14)7-10-18(15)24/h1-2,4-5,8-9,12,15,18H,3,6-7,10-11H2,(H,21,22,23)/t15?,18-/m0/s1
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n/an/a 2.21E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177626
PNG
(US9120769, 90 | US9663470, 90)
Show SMILES O=C(N1CCCC2[C@H]1CCc1ccc(cc21)C#N)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C22H20N4O/c23-12-14-3-4-15-6-8-21-17(18(15)10-14)2-1-9-26(21)22(27)16-5-7-19-20(11-16)25-13-24-19/h3-5,7,10-11,13,17,21H,1-2,6,8-9H2,(H,24,25)/t17?,21-/m1/s1
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n/an/a 2.26E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177604
PNG
(US9120769, 28 | US9663470, 28)
Show SMILES O=C(N1CCCC2[C@H]1CCc1cc(ccc21)-c1ccccc1)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C27H25N3O/c31-27(21-9-12-24-25(16-21)29-17-28-24)30-14-4-7-23-22-11-8-19(18-5-2-1-3-6-18)15-20(22)10-13-26(23)30/h1-3,5-6,8-9,11-12,15-17,23,26H,4,7,10,13-14H2,(H,28,29)/t23?,26-/m1/s1
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n/an/a 2.50E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99402
PNG
(US8497281, 113 | US9120769, 113 | US9663470, 113)
Show SMILES Cn1c2ccc(cc2[nH]c1=O)C(=O)N1CCCC2[C@@H]1Cc1ccccc21
Show InChI InChI=1S/C21H21N3O2/c1-23-18-9-8-14(11-17(18)22-21(23)26)20(25)24-10-4-7-16-15-6-3-2-5-13(15)12-19(16)24/h2-3,5-6,8-9,11,16,19H,4,7,10,12H2,1H3,(H,22,26)/t16?,19-/m0/s1
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n/an/a 2.66E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99340
PNG
(US8497281, 51 | US9120769, 51 | US9663470, 51)
Show SMILES Cn1cnc2cc(ccc12)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C22H23N3O/c1-24-14-23-19-13-16(9-11-21(19)24)22(26)25-12-4-7-18-17-6-3-2-5-15(17)8-10-20(18)25/h2-3,5-6,9,11,13-14,18,20H,4,7-8,10,12H2,1H3/t18?,20-/m0/s1
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n/an/a 2.87E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99353
PNG
(US8497281, 64 | US9120769, 64 | US9663470, 64)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccn2ccnc2c1
Show InChI InChI=1S/C21H21N3O/c25-21(16-9-12-23-13-10-22-20(23)14-16)24-11-3-6-18-17-5-2-1-4-15(17)7-8-19(18)24/h1-2,4-5,9-10,12-14,18-19H,3,6-8,11H2/t18?,19-/m0/s1
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n/an/a 2.87E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99391
PNG
(US8497281, 102 | US9120769, 102 | US9663470, 102)
Show SMILES O=C(N1CCCC2[C@@H]1Cc1ccccc21)c1ccc2[nH]cnc2n1
Show InChI InChI=1S/C19H18N4O/c24-19(16-8-7-15-18(22-16)21-11-20-15)23-9-3-6-14-13-5-2-1-4-12(13)10-17(14)23/h1-2,4-5,7-8,11,14,17H,3,6,9-10H2,(H,20,21,22)/t14?,17-/m0/s1
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n/an/a 3.12E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177608
PNG
(US9120769, 35 | US9663470, 35)
Show SMILES OC(=O)c1ccc2C3CCCN([C@H]3CCc2c1)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C22H21N3O3/c26-21(14-4-7-18-19(11-14)24-12-23-18)25-9-1-2-17-16-6-3-15(22(27)28)10-13(16)5-8-20(17)25/h3-4,6-7,10-12,17,20H,1-2,5,8-9H2,(H,23,24)(H,27,28)/t17?,20-/m0/s1
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n/an/a 3.14E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177634
PNG
(US9120769, 99 | US9663470, 99)
Show SMILES OC(=O)c1ccc2C3CCCN([C@H]3Cc2c1)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C21H19N3O3/c25-20(12-4-6-17-18(9-12)23-11-22-17)24-7-1-2-16-15-5-3-13(21(26)27)8-14(15)10-19(16)24/h3-6,8-9,11,16,19H,1-2,7,10H2,(H,22,23)(H,26,27)/t16?,19-/m0/s1
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n/an/a 3.52E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99335
PNG
(US8497281, 46 | US9120769, 46 | US9663470, 46)
Show SMILES Cc1cc2cc(ccc2[nH]1)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C23H24N2O/c1-15-13-18-14-17(8-10-21(18)24-15)23(26)25-12-4-7-20-19-6-3-2-5-16(19)9-11-22(20)25/h2-3,5-6,8,10,13-14,20,22,24H,4,7,9,11-12H2,1H3/t20?,22-/m0/s1
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n/an/a 3.62E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99339
PNG
(US8497281, 50 | US9120769, 50 | US9663470, 50)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2CC(=O)Nc2c1
Show InChI InChI=1S/C22H22N2O2/c25-21-13-15-7-8-16(12-19(15)23-21)22(26)24-11-3-6-18-17-5-2-1-4-14(17)9-10-20(18)24/h1-2,4-5,7-8,12,18,20H,3,6,9-11,13H2,(H,23,25)/t18?,20-/m0/s1
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n/an/a 4.27E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177642
PNG
(US9120769, 121 | US9663470, 121)
Show SMILES Cc1nc2cc(ccc2[nH]1)C(=O)N1CCCC2[C@@H]1Cc1ccccc21
Show InChI InChI=1S/C21H21N3O/c1-13-22-18-9-8-15(11-19(18)23-13)21(25)24-10-4-7-17-16-6-3-2-5-14(16)12-20(17)24/h2-3,5-6,8-9,11,17,20H,4,7,10,12H2,1H3,(H,22,23)/t17?,20-/m0/s1
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n/an/a 4.44E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99344
PNG
(US8497281, 55 | US9120769, 55 | US9663470, 55)
Show SMILES Cc1nc2ccc(cc2[nH]1)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C22H23N3O/c1-14-23-19-10-8-16(13-20(19)24-14)22(26)25-12-4-7-18-17-6-3-2-5-15(17)9-11-21(18)25/h2-3,5-6,8,10,13,18,21H,4,7,9,11-12H2,1H3,(H,23,24)/t18?,21-/m0/s1
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n/an/a 4.68E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99420
PNG
(US8497281, 131 | US9120769, 131 | US9663470, 131)
Show SMILES O=C(N1CCCC2[C@@H]1Cc1ccccc21)c1ccn2ccnc2c1
Show InChI InChI=1S/C20H19N3O/c24-20(15-7-10-22-11-8-21-19(22)13-15)23-9-3-6-17-16-5-2-1-4-14(16)12-18(17)23/h1-2,4-5,7-8,10-11,13,17-18H,3,6,9,12H2/t17?,18-/m0/s1
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n/an/a 6.43E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177623
PNG
(US9120769, 87 | US9663470, 87)
Show SMILES NC(=O)c1cccc2CC[C@H]3C(CCCN3C(=O)c3ccc4[nH]cnc4c3)c12
Show InChI InChI=1S/C22H22N4O2/c23-21(27)16-4-1-3-13-7-9-19-15(20(13)16)5-2-10-26(19)22(28)14-6-8-17-18(11-14)25-12-24-17/h1,3-4,6,8,11-12,15,19H,2,5,7,9-10H2,(H2,23,27)(H,24,25)/t15?,19-/m0/s1
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n/an/a 8.85E+3n/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh

US Patent


Assay Description
In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...


US Patent US9663470 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%