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Patent code US9663476

Compile Data Set for Download or QSAR
Found 18 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glycine transporter 1


(Homo sapiens (Human))		BDBM327829
PNG
(2-((R)-4-((S)-(3-bromophenyl)(phenyl)methyl)-2-met...)
Show SMILES C[C@@H]1CN(CCN1CC(O)=O)[C@@H](c1ccccc1)c1cccc(Br)c1
Show InChI InChI=1S/C20H23BrN2O2/c1-15-13-23(11-10-22(15)14-19(24)25)20(16-6-3-2-4-7-16)17-8-5-9-18(21)12-17/h2-9,12,15,20H,10-11,13-14H2,1H3,(H,24,25)/t15-,20+/m1/s1
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US Patent
n/an/a 0.934n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...

US Patent US9663476 (2017)

More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))		BDBM327832
PNG
(2-((R)-2-methyl-4-((R)-phenyl(3-(trifluoromethyl)p...)
Show SMILES C[C@@H]1CN(CCN1CC(O)=O)[C@H](c1ccccc1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H23F3N2O2/c1-15-13-26(11-10-25(15)14-19(27)28)20(16-6-3-2-4-7-16)17-8-5-9-18(12-17)21(22,23)24/h2-9,12,15,20H,10-11,13-14H2,1H3,(H,27,28)/t15-,20-/m1/s1
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n/an/a 0.980n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...

US Patent US9663476 (2017)

More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))		BDBM327844
PNG
(2-((R)-4-(cyclopropyl(3-(trifluoromethyl)phenyl)me...)
Show SMILES C[C@@H]1CN(CCN1CC(O)=O)C(C1CC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C18H23F3N2O2/c1-12-10-23(8-7-22(12)11-16(24)25)17(13-5-6-13)14-3-2-4-15(9-14)18(19,20)21/h2-4,9,12-13,17H,5-8,10-11H2,1H3,(H,24,25)/t12-,17?/m1/s1
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n/an/a 1.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...

US Patent US9663476 (2017)

More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))		BDBM327827
PNG
((R)-2-(4-benzhydryl-2-methylpiperazin-1-yl)acetic ...)
Show SMILES C[C@@H]1CN(CCN1CC(O)=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C20H24N2O2/c1-16-14-22(13-12-21(16)15-19(23)24)20(17-8-4-2-5-9-17)18-10-6-3-7-11-18/h2-11,16,20H,12-15H2,1H3,(H,23,24)/t16-/m1/s1
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n/an/a 1.51n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...

US Patent US9663476 (2017)

More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))		BDBM327833
PNG
((S)-2-((R)-4-(bis(4-chlorophenyl)methyl)-3-methylp...)
Show SMILES C[C@H](N1CCN(C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)[C@H](C)C1)C(O)=O
Show InChI InChI=1S/C21H24Cl2N2O2/c1-14-13-24(15(2)21(26)27)11-12-25(14)20(16-3-7-18(22)8-4-16)17-5-9-19(23)10-6-17/h3-10,14-15,20H,11-13H2,1-2H3,(H,26,27)/t14-,15+/m1/s1
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n/an/a 2.14n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...

US Patent US9663476 (2017)

More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))		BDBM327842
PNG
(2-((R)-2-methyl-4-((R)-phenyl(4-(2-phenylethynyl)p...)
Show SMILES C[C@@H]1CN(CCN1CC(O)=O)[C@H](c1ccccc1)c1ccc(cc1)C#Cc1ccccc1
Show InChI InChI=1S/C28H28N2O2/c1-22-20-30(19-18-29(22)21-27(31)32)28(25-10-6-3-7-11-25)26-16-14-24(15-17-26)13-12-23-8-4-2-5-9-23/h2-11,14-17,22,28H,18-21H2,1H3,(H,31,32)/t22-,28-/m1/s1
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n/an/a 2.70n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...

US Patent US9663476 (2017)

More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))		BDBM327828
PNG
(2-((R)-4-((R)-(3-bromophenyl)(phenyl)methyl)-2-met...)
Show SMILES C[C@@H]1CN(CCN1CC(O)=O)[C@H](c1ccccc1)c1cccc(Br)c1
Show InChI InChI=1S/C20H23BrN2O2/c1-15-13-23(11-10-22(15)14-19(24)25)20(16-6-3-2-4-7-16)17-8-5-9-18(21)12-17/h2-9,12,15,20H,10-11,13-14H2,1H3,(H,24,25)/t15-,20-/m1/s1
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n/an/a 3.94n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...

US Patent US9663476 (2017)

More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))		BDBM327835
PNG
(2-((R)-2-methyl-4-((R)-phenyl(m-tolyl)methyl)piper...)
Show SMILES C[C@@H]1CN(CCN1CC(O)=O)[C@H](c1ccccc1)c1cccc(C)c1
Show InChI InChI=1S/C21H26N2O2/c1-16-7-6-10-19(13-16)21(18-8-4-3-5-9-18)23-12-11-22(15-20(24)25)17(2)14-23/h3-10,13,17,21H,11-12,14-15H2,1-2H3,(H,24,25)/t17-,21-/m1/s1
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n/an/a 4.32n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...

US Patent US9663476 (2017)

More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))		BDBM327836
PNG
(2-((R)-2-methyl-4-((R)-phenyl(3-(thiophen-2-yl)phe...)
Show SMILES C[C@@H]1CN(CCN1CC(O)=O)[C@H](c1ccccc1)c1cccc(c1)-c1cccs1
Show InChI InChI=1S/C24H26N2O2S/c1-18-16-26(13-12-25(18)17-23(27)28)24(19-7-3-2-4-8-19)21-10-5-9-20(15-21)22-11-6-14-29-22/h2-11,14-15,18,24H,12-13,16-17H2,1H3,(H,27,28)/t18-,24-/m1/s1
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n/an/a 4.80n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...

US Patent US9663476 (2017)

More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))		BDBM327834
PNG
(US9663476, Compound 30 | [(R)-4-((R)-biphenyl-3-yl...)
Show SMILES C[C@@H]1CN(CCN1CC(O)=O)[C@H](c1ccccc1)c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C26H28N2O2/c1-20-18-28(16-15-27(20)19-25(29)30)26(22-11-6-3-7-12-22)24-14-8-13-23(17-24)21-9-4-2-5-10-21/h2-14,17,20,26H,15-16,18-19H2,1H3,(H,29,30)/t20-,26-/m1/s1
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n/an/a 7.20n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...

US Patent US9663476 (2017)

More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))		BDBM327841
PNG
(US9663476, Compound 49 | [(R)-2-methyl-4-[(R)-(4&#...)
Show SMILES C[C@@H]1CN(CCN1CC(O)=O)[C@H](c1ccccc1)c1ccc(cc1)-c1ccc(C)cc1
Show InChI InChI=1S/C27H30N2O2/c1-20-8-10-22(11-9-20)23-12-14-25(15-13-23)27(24-6-4-3-5-7-24)29-17-16-28(19-26(30)31)21(2)18-29/h3-15,21,27H,16-19H2,1-2H3,(H,30,31)/t21-,27-/m1/s1
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n/an/a 17.8n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...

US Patent US9663476 (2017)

More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))		BDBM327838
PNG
(2-((R)-2-methyl-4-((R)-(3-(methylthio)phenyl)(phen...)
Show SMILES CSc1cccc(c1)[C@H](N1CCN(CC(O)=O)[C@H](C)C1)c1ccccc1
Show InChI InChI=1S/C21H26N2O2S/c1-16-14-23(12-11-22(16)15-20(24)25)21(17-7-4-3-5-8-17)18-9-6-10-19(13-18)26-2/h3-10,13,16,21H,11-12,14-15H2,1-2H3,(H,24,25)/t16-,21-/m1/s1
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n/an/a 37.6n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...

US Patent US9663476 (2017)

More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))		BDBM327845
PNG
((R)-2-(4-(bis(4-chlorophenyl)methyl)-2-methylpiper...)
Show SMILES C[C@@H]1CN(CCN1CC(O)=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H22Cl2N2O2/c1-14-12-24(11-10-23(14)13-19(25)26)20(15-2-6-17(21)7-3-15)16-4-8-18(22)9-5-16/h2-9,14,20H,10-13H2,1H3,(H,25,26)/t14-/m1/s1
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n/an/a 41.1n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...

US Patent US9663476 (2017)

More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))		BDBM327826
PNG
((R)-2-(4-(phenyl(3-(trifluoromethyl)phenyl)methyl)...)
Show SMILES OC(=O)CN1CCN(CC1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H20Cl2N2O2/c20-16-5-1-14(2-6-16)19(15-3-7-17(21)8-4-15)23-11-9-22(10-12-23)13-18(24)25/h1-8,19H,9-13H2,(H,24,25)
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n/an/a 79.1n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...

US Patent US9663476 (2017)

More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))		BDBM327826
PNG
((R)-2-(4-(phenyl(3-(trifluoromethyl)phenyl)methyl)...)
Show SMILES OC(=O)CN1CCN(CC1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H20Cl2N2O2/c20-16-5-1-14(2-6-16)19(15-3-7-17(21)8-4-15)23-11-9-22(10-12-23)13-18(24)25/h1-8,19H,9-13H2,(H,24,25)
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n/an/a 134n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...

US Patent US9663476 (2017)

More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))		BDBM327839
PNG
(US9663476, Compound 48 | [(R)-2-methyl-4-[(R)-(3&#...)
Show SMILES C[C@@H]1CN(CCN1CC(O)=O)[C@H](c1ccccc1)c1ccc(cc1)-c1cccc(C)c1
Show InChI InChI=1S/C27H30N2O2/c1-20-7-6-10-25(17-20)22-11-13-24(14-12-22)27(23-8-4-3-5-9-23)29-16-15-28(19-26(30)31)21(2)18-29/h3-14,17,21,27H,15-16,18-19H2,1-2H3,(H,30,31)/t21-,27-/m1/s1
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n/an/a 217n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...

US Patent US9663476 (2017)

More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))		BDBM327840
PNG
((R)-2-((R)-4-(bis(4-chlorophenyl)methyl)-2-methylp...)
Show SMILES C[C@@H](N1CCN(C[C@H]1C)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C21H24Cl2N2O2/c1-14-13-24(11-12-25(14)15(2)21(26)27)20(16-3-7-18(22)8-4-16)17-5-9-19(23)10-6-17/h3-10,14-15,20H,11-13H2,1-2H3,(H,26,27)/t14-,15-/m1/s1
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n/an/a 1.19E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...

US Patent US9663476 (2017)

More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))		BDBM327843
PNG
(2-((R)-2-methyl-4-((R)-thiophen-2-yl(3-(trifluorom...)
Show SMILES C[C@@H]1CN(CCN1CC(O)=O)[C@@H](c1cccs1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C19H21F3N2O2S/c1-13-11-24(8-7-23(13)12-17(25)26)18(16-6-3-9-27-16)14-4-2-5-15(10-14)19(20,21)22/h2-6,9-10,13,18H,7-8,11-12H2,1H3,(H,25,26)/t13-,18-/m1/s1
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n/an/a 2.20E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...

US Patent US9663476 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%