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Patent code US9663476

Compile Data Set for Download or QSAR
Found 18 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycine transporter 1


(Homo sapiens (Human))
BDBM327845
PNG
((R)-2-(4-(bis(4-chlorophenyl)methyl)-2-methylpiper...)
Show SMILES C[C@@H]1CN(CCN1CC(O)=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H22Cl2N2O2/c1-14-12-24(11-10-23(14)13-19(25)26)20(15-2-6-17(21)7-3-15)16-4-8-18(22)9-5-16/h2-9,14,20H,10-13H2,1H3,(H,25,26)/t14-/m1/s1
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US Patent
n/an/a 41.1n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...


US Patent US9663476 (2017)


Article DOI: 10.1016/j.bmcl.2009.04.124
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM327839
PNG
(US9663476, Compound 48 | [(R)-2-methyl-4-[(R)-(3&#...)
Show SMILES C[C@@H]1CN(CCN1CC(O)=O)[C@H](c1ccccc1)c1ccc(cc1)-c1cccc(C)c1
Show InChI InChI=1S/C27H30N2O2/c1-20-7-6-10-25(17-20)22-11-13-24(14-12-22)27(23-8-4-3-5-9-23)29-16-15-28(19-26(30)31)21(2)18-29/h3-14,17,21,27H,15-16,18-19H2,1-2H3,(H,30,31)/t21-,27-/m1/s1
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n/an/a 217n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...


US Patent US9663476 (2017)


Article DOI: 10.1016/j.bmcl.2009.04.124
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM327833
PNG
((S)-2-((R)-4-(bis(4-chlorophenyl)methyl)-3-methylp...)
Show SMILES C[C@H](N1CCN(C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)[C@H](C)C1)C(O)=O
Show InChI InChI=1S/C21H24Cl2N2O2/c1-14-13-24(15(2)21(26)27)11-12-25(14)20(16-3-7-18(22)8-4-16)17-5-9-19(23)10-6-17/h3-10,14-15,20H,11-13H2,1-2H3,(H,26,27)/t14-,15+/m1/s1
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n/an/a 2.14n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...


US Patent US9663476 (2017)


Article DOI: 10.1016/j.bmcl.2009.04.124
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM327836
PNG
(2-((R)-2-methyl-4-((R)-phenyl(3-(thiophen-2-yl)phe...)
Show SMILES C[C@@H]1CN(CCN1CC(O)=O)[C@H](c1ccccc1)c1cccc(c1)-c1cccs1
Show InChI InChI=1S/C24H26N2O2S/c1-18-16-26(13-12-25(18)17-23(27)28)24(19-7-3-2-4-8-19)21-10-5-9-20(15-21)22-11-6-14-29-22/h2-11,14-15,18,24H,12-13,16-17H2,1H3,(H,27,28)/t18-,24-/m1/s1
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n/an/a 4.80n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...


US Patent US9663476 (2017)


Article DOI: 10.1016/j.bmcl.2009.04.124
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM327826
PNG
((R)-2-(4-(phenyl(3-(trifluoromethyl)phenyl)methyl)...)
Show SMILES OC(=O)CN1CCN(CC1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H20Cl2N2O2/c20-16-5-1-14(2-6-16)19(15-3-7-17(21)8-4-15)23-11-9-22(10-12-23)13-18(24)25/h1-8,19H,9-13H2,(H,24,25)
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n/an/a 79.1n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...


US Patent US9663476 (2017)


Article DOI: 10.1016/j.bmcl.2009.04.124
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM327834
PNG
(US9663476, Compound 30 | [(R)-4-((R)-biphenyl-3-yl...)
Show SMILES C[C@@H]1CN(CCN1CC(O)=O)[C@H](c1ccccc1)c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C26H28N2O2/c1-20-18-28(16-15-27(20)19-25(29)30)26(22-11-6-3-7-12-22)24-14-8-13-23(17-24)21-9-4-2-5-10-21/h2-14,17,20,26H,15-16,18-19H2,1H3,(H,29,30)/t20-,26-/m1/s1
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n/an/a 7.20n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...


US Patent US9663476 (2017)


Article DOI: 10.1016/j.bmcl.2009.04.124
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM327826
PNG
((R)-2-(4-(phenyl(3-(trifluoromethyl)phenyl)methyl)...)
Show SMILES OC(=O)CN1CCN(CC1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H20Cl2N2O2/c20-16-5-1-14(2-6-16)19(15-3-7-17(21)8-4-15)23-11-9-22(10-12-23)13-18(24)25/h1-8,19H,9-13H2,(H,24,25)
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n/an/a 134n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...


US Patent US9663476 (2017)


Article DOI: 10.1016/j.bmcl.2009.04.124
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM327841
PNG
(US9663476, Compound 49 | [(R)-2-methyl-4-[(R)-(4&#...)
Show SMILES C[C@@H]1CN(CCN1CC(O)=O)[C@H](c1ccccc1)c1ccc(cc1)-c1ccc(C)cc1
Show InChI InChI=1S/C27H30N2O2/c1-20-8-10-22(11-9-20)23-12-14-25(15-13-23)27(24-6-4-3-5-7-24)29-17-16-28(19-26(30)31)21(2)18-29/h3-15,21,27H,16-19H2,1-2H3,(H,30,31)/t21-,27-/m1/s1
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n/an/a 17.8n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...


US Patent US9663476 (2017)


Article DOI: 10.1016/j.bmcl.2009.04.124
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM327842
PNG
(2-((R)-2-methyl-4-((R)-phenyl(4-(2-phenylethynyl)p...)
Show SMILES C[C@@H]1CN(CCN1CC(O)=O)[C@H](c1ccccc1)c1ccc(cc1)C#Cc1ccccc1
Show InChI InChI=1S/C28H28N2O2/c1-22-20-30(19-18-29(22)21-27(31)32)28(25-10-6-3-7-11-25)26-16-14-24(15-17-26)13-12-23-8-4-2-5-9-23/h2-11,14-17,22,28H,18-21H2,1H3,(H,31,32)/t22-,28-/m1/s1
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n/an/a 2.70n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...


US Patent US9663476 (2017)


Article DOI: 10.1016/j.bmcl.2009.04.124
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM327843
PNG
(2-((R)-2-methyl-4-((R)-thiophen-2-yl(3-(trifluorom...)
Show SMILES C[C@@H]1CN(CCN1CC(O)=O)[C@@H](c1cccs1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C19H21F3N2O2S/c1-13-11-24(8-7-23(13)12-17(25)26)18(16-6-3-9-27-16)14-4-2-5-15(10-14)19(20,21)22/h2-6,9-10,13,18H,7-8,11-12H2,1H3,(H,25,26)/t13-,18-/m1/s1
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n/an/a 2.20E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...


US Patent US9663476 (2017)


Article DOI: 10.1016/j.bmcl.2009.04.124
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM327838
PNG
(2-((R)-2-methyl-4-((R)-(3-(methylthio)phenyl)(phen...)
Show SMILES CSc1cccc(c1)[C@H](N1CCN(CC(O)=O)[C@H](C)C1)c1ccccc1
Show InChI InChI=1S/C21H26N2O2S/c1-16-14-23(12-11-22(16)15-20(24)25)21(17-7-4-3-5-8-17)18-9-6-10-19(13-18)26-2/h3-10,13,16,21H,11-12,14-15H2,1-2H3,(H,24,25)/t16-,21-/m1/s1
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n/an/a 37.6n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...


US Patent US9663476 (2017)


Article DOI: 10.1016/j.bmcl.2009.04.124
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM327840
PNG
((R)-2-((R)-4-(bis(4-chlorophenyl)methyl)-2-methylp...)
Show SMILES C[C@@H](N1CCN(C[C@H]1C)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C21H24Cl2N2O2/c1-14-13-24(11-12-25(14)15(2)21(26)27)20(16-3-7-18(22)8-4-16)17-5-9-19(23)10-6-17/h3-10,14-15,20H,11-13H2,1-2H3,(H,26,27)/t14-,15-/m1/s1
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n/an/a 1.19E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...


US Patent US9663476 (2017)


Article DOI: 10.1016/j.bmcl.2009.04.124
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM327829
PNG
(2-((R)-4-((S)-(3-bromophenyl)(phenyl)methyl)-2-met...)
Show SMILES C[C@@H]1CN(CCN1CC(O)=O)[C@@H](c1ccccc1)c1cccc(Br)c1
Show InChI InChI=1S/C20H23BrN2O2/c1-15-13-23(11-10-22(15)14-19(24)25)20(16-6-3-2-4-7-16)17-8-5-9-18(21)12-17/h2-9,12,15,20H,10-11,13-14H2,1H3,(H,24,25)/t15-,20+/m1/s1
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n/an/a 0.934n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...


US Patent US9663476 (2017)


Article DOI: 10.1016/j.bmcl.2009.04.124
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM327844
PNG
(2-((R)-4-(cyclopropyl(3-(trifluoromethyl)phenyl)me...)
Show SMILES C[C@@H]1CN(CCN1CC(O)=O)C(C1CC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C18H23F3N2O2/c1-12-10-23(8-7-22(12)11-16(24)25)17(13-5-6-13)14-3-2-4-15(9-14)18(19,20)21/h2-4,9,12-13,17H,5-8,10-11H2,1H3,(H,24,25)/t12-,17?/m1/s1
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n/an/a 1.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...


US Patent US9663476 (2017)


Article DOI: 10.1016/j.bmcl.2009.04.124
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM327828
PNG
(2-((R)-4-((R)-(3-bromophenyl)(phenyl)methyl)-2-met...)
Show SMILES C[C@@H]1CN(CCN1CC(O)=O)[C@H](c1ccccc1)c1cccc(Br)c1
Show InChI InChI=1S/C20H23BrN2O2/c1-15-13-23(11-10-22(15)14-19(24)25)20(16-6-3-2-4-7-16)17-8-5-9-18(21)12-17/h2-9,12,15,20H,10-11,13-14H2,1H3,(H,24,25)/t15-,20-/m1/s1
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n/an/a 3.94n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...


US Patent US9663476 (2017)


Article DOI: 10.1016/j.bmcl.2009.04.124
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM327827
PNG
((R)-2-(4-benzhydryl-2-methylpiperazin-1-yl)acetic ...)
Show SMILES C[C@@H]1CN(CCN1CC(O)=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C20H24N2O2/c1-16-14-22(13-12-21(16)15-19(23)24)20(17-8-4-2-5-9-17)18-10-6-3-7-11-18/h2-11,16,20H,12-15H2,1H3,(H,23,24)/t16-/m1/s1
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n/an/a 1.51n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...


US Patent US9663476 (2017)


Article DOI: 10.1016/j.bmcl.2009.04.124
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM327832
PNG
(2-((R)-2-methyl-4-((R)-phenyl(3-(trifluoromethyl)p...)
Show SMILES C[C@@H]1CN(CCN1CC(O)=O)[C@H](c1ccccc1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H23F3N2O2/c1-15-13-26(11-10-25(15)14-19(27)28)20(16-6-3-2-4-7-16)17-8-5-9-18(12-17)21(22,23)24/h2-9,12,15,20H,10-11,13-14H2,1H3,(H,27,28)/t15-,20-/m1/s1
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n/an/a 0.980n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...


US Patent US9663476 (2017)


Article DOI: 10.1016/j.bmcl.2009.04.124
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM327835
PNG
(2-((R)-2-methyl-4-((R)-phenyl(m-tolyl)methyl)piper...)
Show SMILES C[C@@H]1CN(CCN1CC(O)=O)[C@H](c1ccccc1)c1cccc(C)c1
Show InChI InChI=1S/C21H26N2O2/c1-16-7-6-10-19(13-16)21(18-8-4-3-5-9-18)23-12-11-22(15-20(24)25)17(2)14-23/h3-10,13,17,21H,11-12,14-15H2,1-2H3,(H,24,25)/t17-,21-/m1/s1
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n/an/a 4.32n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...


US Patent US9663476 (2017)


Article DOI: 10.1016/j.bmcl.2009.04.124
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%