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Patent code US9663496

Compile Data Set for Download or QSAR

Found 493 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
ampk


(Homo sapiens (Human))		BDBM328256
PNG
(N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4-meth...)
Show SMILES COc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c(NC(=O)CCOCCOCCOCCOCCNC(=O)CCCC[C@@H]2SC[C@@H]3NC(=O)N[C@H]23)c1
Show InChI InChI=1S/C53H71N9O11S/c1-68-42-11-13-46(73-41-16-22-62(23-17-41)52(66)43-12-10-39(34-56-43)51(65)57-40-14-20-61(21-15-40)35-38-8-6-37(33-54)7-9-38)44(32-42)58-49(64)18-24-69-26-28-71-30-31-72-29-27-70-25-19-55-48(63)5-3-2-4-47-50-45(36-74-47)59-53(67)60-50/h6-13,32,34,40-41,45,47,50H,2-5,14-31,35-36H2,1H3,(H,55,63)(H,57,65)(H,58,64)(H2,59,60,67)/t45-,47-,50-/m0/s1
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Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328260
PNG
(N-(4-(4-cyanophenoxy) cyclohexyl)-6-(4-(4- (methy...)
Show SMILES CS(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCC(CC2)Oc2ccc(cc2)C#N)cc1
Show InChI InChI=1S/C32H34N4O6S/c1-43(39,40)29-13-11-27(12-14-29)42-28-16-18-36(19-17-28)32(38)30-15-4-23(21-34-30)31(37)35-24-5-9-26(10-6-24)41-25-7-2-22(20-33)3-8-25/h2-4,7-8,11-15,21,24,26,28H,5-6,9-10,16-19H2,1H3,(H,35,37)
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Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328273
PNG
(6-(4-(3- acetamidophenoxy) piperidine-1-carbonyl)...)
Show SMILES CC(=O)Nc1cccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c1
Show InChI InChI=1S/C33H36N6O4/c1-23(40)36-28-3-2-4-30(19-28)43-29-13-17-39(18-14-29)33(42)31-10-9-26(21-35-31)32(41)37-27-11-15-38(16-12-27)22-25-7-5-24(20-34)6-8-25/h2-10,19,21,27,29H,11-18,22H2,1H3,(H,36,40)(H,37,41)
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Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328275
PNG
(6-(4-(3- acetamidophenoxy) piperidine-1-carbonyl)...)
Show SMILES CC(=O)Nc1cccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(F)cc3)CC2)c1
Show InChI InChI=1S/C32H36FN5O4/c1-22(39)35-27-3-2-4-29(19-27)42-28-13-17-38(18-14-28)32(41)30-10-7-24(20-34-30)31(40)36-26-11-15-37(16-12-26)21-23-5-8-25(33)9-6-23/h2-10,19-20,26,28H,11-18,21H2,1H3,(H,35,39)(H,36,40)
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n/an/an/an/a 3.00E+3n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328276
PNG
(6-(4-(3- acetamidophenoxy) piperidine-1-carbonyl)...)
Show SMILES CC(=O)Nc1cccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)c1
Show InChI InChI=1S/C31H28FN5O5/c1-20(38)35-23-3-2-4-27(17-23)41-26-13-15-37(16-14-26)31(40)28-11-5-21(18-33-28)30(39)36-24-8-12-29(34-19-24)42-25-9-6-22(32)7-10-25/h2-12,17-19,26H,13-16H2,1H3,(H,35,38)(H,36,39)
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Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328278
PNG
(US10377742, Compound 416 | US9663496, Compound 416...)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ncc(cc1CCCNC(=O)OC(C)(C)C)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1
Show InChI InChI=1S/C41H50N6O6/c1-41(2,3)53-40(51)43-19-5-6-32-24-33(38(49)45-34-17-20-46(21-18-34)27-29-9-7-28(25-42)8-10-29)26-44-36(32)39(50)47-22-15-31(16-23-47)37(48)30-11-13-35(52-4)14-12-30/h7-14,24,26,31,34H,5-6,15-23,27H2,1-4H3,(H,43,51)(H,45,49)
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Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328281
PNG
(N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(thioph...)
Show SMILES O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCC(CC1)C(=O)c1cccs1
Show InChI InChI=1S/C30H31N5O3S/c31-18-21-3-5-22(6-4-21)20-34-13-11-25(12-14-34)33-29(37)26-8-7-24(19-32-26)30(38)35-15-9-23(10-16-35)28(36)27-2-1-17-39-27/h1-8,17,19,23,25H,9-16,20H2,(H,33,37)
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Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328295
PNG
(6-(4-(3-(cyclopropane- carboxamido)phenoxy) piper...)
Show SMILES Fc1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)Oc3cccc(NC(=O)C4CC4)c3)cn2)cc1
Show InChI InChI=1S/C33H30FN5O5/c34-23-7-10-26(11-8-23)44-30-13-9-25(20-36-30)38-32(41)22-6-12-29(35-19-22)33(42)39-16-14-27(15-17-39)43-28-3-1-2-24(18-28)37-31(40)21-4-5-21/h1-3,6-13,18-21,27H,4-5,14-17H2,(H,37,40)(H,38,41)
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Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328298
PNG
(N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- (tr...)
Show SMILES FC(F)(F)Sc1ccc(OC2CCN(CC2)C(=O)c2ccc(nn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1
Show InChI InChI=1S/C31H31F3N6O3S/c32-31(33,34)44-26-7-5-24(6-8-26)43-25-13-17-40(18-14-25)30(42)28-10-9-27(37-38-28)29(41)36-23-11-15-39(16-12-23)20-22-3-1-21(19-35)2-4-22/h1-10,23,25H,11-18,20H2,(H,36,41)
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Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328307
PNG
(6-(4-(4-methoxybenzoyl) piperidine-1-carbonyl)- N...)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCNCC1
Show InChI InChI=1S/C25H30N4O4/c1-33-21-5-2-17(3-6-21)23(30)18-10-14-29(15-11-18)25(32)22-7-4-19(16-27-22)24(31)28-20-8-12-26-13-9-20/h2-7,16,18,20,26H,8-15H2,1H3,(H,28,31)
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Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328309
PNG
(N-(1-(4-cyano-3- fluorobenzyl)piperidin- 4-yl)-6-(...)
Show SMILES Fc1cc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)N2CCCC2)ccc1C#N
Show InChI InChI=1S/C36H39FN6O3/c37-32-21-25(3-4-28(32)22-38)24-41-17-13-30(14-18-41)40-35(45)29-7-10-33(39-23-29)36(46)43-19-11-27(12-20-43)34(44)26-5-8-31(9-6-26)42-15-1-2-16-42/h3-10,21,23,27,30H,1-2,11-20,24H2,(H,40,45)
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Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328312
PNG
(N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- (tr...)
Show SMILES FC(F)(F)S(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1
Show InChI InChI=1S/C32H32F3N5O5S/c33-32(34,35)46(43,44)28-8-6-26(7-9-28)45-27-13-17-40(18-14-27)31(42)29-10-5-24(20-37-29)30(41)38-25-11-15-39(16-12-25)21-23-3-1-22(19-36)2-4-23/h1-10,20,25,27H,11-18,21H2,(H,38,41)
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Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328335
PNG
(N-(6-(4- acetylphenoxy)pyridin- 3-yl)-6-(4-(4- flu...)
Show SMILES CC(=O)c1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)S(=O)(=O)c3ccc(F)cc3)cn2)cc1
Show InChI InChI=1S/C31H27FN4O6S/c1-20(37)21-2-8-25(9-3-21)42-29-13-7-24(19-34-29)35-30(38)22-4-12-28(33-18-22)31(39)36-16-14-27(15-17-36)43(40,41)26-10-5-23(32)6-11-26/h2-13,18-19,27H,14-17H2,1H3,(H,35,38)
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n/an/an/an/a 3.00E+3n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328336
PNG
(6-(4-(4- fluorophenylsulfonyl) piperidine-1-carbo...)
Show SMILES COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)S(=O)(=O)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C31H35FN4O5S/c1-41-26-7-2-22(3-8-26)21-35-16-12-25(13-17-35)34-30(37)23-4-11-29(33-20-23)31(38)36-18-14-28(15-19-36)42(39,40)27-9-5-24(32)6-10-27/h2-11,20,25,28H,12-19,21H2,1H3,(H,34,37)
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Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328339
PNG
(N-(6-(4- acetylphenoxy)pyridin- 3-yl)-6-(4-(4- flu...)
Show SMILES CC(=O)c1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCN(Cc4ccc(F)cc4)CC3)cn2)cc1
Show InChI InChI=1S/C31H28FN5O4/c1-21(38)23-4-10-27(11-5-23)41-29-13-9-26(19-34-29)35-30(39)24-6-12-28(33-18-24)31(40)37-16-14-36(15-17-37)20-22-2-7-25(32)8-3-22/h2-13,18-19H,14-17,20H2,1H3,(H,35,39)
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Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328341
PNG
(N-(6-(4-cyanophenoxy)- 2-methylpyridin-3-yl)-6- (4...)
Show SMILES Cc1nc(Oc2ccc(cc2)C#N)ccc1NC(=O)c1ccc(nc1)C(=O)N1CCC(CC1)C(=O)c1ccc(F)cc1F
Show InChI InChI=1S/C32H25F2N5O4/c1-19-27(10-11-29(37-19)43-24-6-2-20(17-35)3-7-24)38-31(41)22-4-9-28(36-18-22)32(42)39-14-12-21(13-15-39)30(40)25-8-5-23(33)16-26(25)34/h2-11,16,18,21H,12-15H2,1H3,(H,38,41)
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Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328356
PNG
(6-(4-(4- (pentafluorosulfanyl) phenoxy)piperidine...)
Show SMILES FC(F)(F)Oc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(cc2)S(F)(F)(F)(F)F)cc1
Show InChI InChI=1S/C31H32F8N4O4S/c32-31(33,34)47-26-4-1-21(2-5-26)20-42-15-11-23(12-16-42)41-29(44)22-3-10-28(40-19-22)30(45)43-17-13-25(14-18-43)46-24-6-8-27(9-7-24)48(35,36,37,38)39/h1-10,19,23,25H,11-18,20H2,(H,41,44)
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n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM327866
PNG
(N2-(1-(4- cyanobenzyl)piperidin-4- yl)-N5-(3- benz...)
Show SMILES O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)Nc1cccc(Cc2ccccc2)c1
Show InChI InChI=1S/C33H31N5O2/c34-21-25-9-11-26(12-10-25)23-38-17-15-29(16-18-38)36-33(40)31-14-13-28(22-35-31)32(39)37-30-8-4-7-27(20-30)19-24-5-2-1-3-6-24/h1-14,20,22,29H,15-19,23H2,(H,36,40)(H,37,39)
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Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM327867
PNG
(N-(4-((4- cyanophenyl)sulfonyl) piperidin-4-yl)-5...)
Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(CC2)S(=O)(=O)c2ccc(cc2)C#N)cc1
Show InChI InChI=1S/C30H31FN6O4S/c31-25-6-1-23(2-7-25)21-35-15-17-36(18-16-35)30(39)24-5-10-28(33-20-24)29(38)34-26-11-13-37(14-12-26)42(40,41)27-8-3-22(19-32)4-9-27/h1-10,20,26H,11-18,21H2,(H,34,38)
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Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM327880
PNG
(5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(2...)
Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccccc2-c2ccccc2)cc1
Show InChI InChI=1S/C30H27FN4O2/c31-25-13-10-22(11-14-25)21-34-16-18-35(19-17-34)30(37)24-12-15-28(32-20-24)29(36)33-27-9-5-4-8-26(27)23-6-2-1-3-7-23/h1-15,20H,16-19,21H2,(H,33,36)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM327904
PNG
((6-(3-(4- cyanobenzylcarbamoyl) phenyl)pyridin-3y...)
Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)-c2cccc(c2)C(=O)NCc2ccc(cc2)C#N)cc1
Show InChI InChI=1S/C32H28FN5O2/c33-29-11-8-25(9-12-29)22-37-14-16-38(17-15-37)32(40)28-10-13-30(35-21-28)26-2-1-3-27(18-26)31(39)36-20-24-6-4-23(19-34)5-7-24/h1-13,18,21H,14-17,20,22H2,(H,36,39)
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n/an/an/an/a 3.00E+3n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM327920
PNG
(5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4...)
Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(cc2)-c2cccnc2)cc1
Show InChI InChI=1S/C29H26FN5O2/c30-25-8-3-21(4-9-25)20-34-14-16-35(17-15-34)29(37)24-7-12-27(32-19-24)28(36)33-26-10-5-22(6-11-26)23-2-1-13-31-18-23/h1-13,18-19H,14-17,20H2,(H,33,36)
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n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM327934
PNG
(N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- flu...)
Show SMILES Fc1ccc(cc1)C(=O)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1
Show InChI InChI=1S/C31H31FN6O3/c32-26-8-5-24(6-9-26)30(40)37-15-17-38(18-16-37)31(41)25-7-10-28(34-20-25)29(39)35-27-11-13-36(14-12-27)21-23-3-1-22(19-33)2-4-23/h1-10,20,27H,11-18,21H2,(H,35,39)
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n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM327937
PNG
(N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- met...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1
Show InChI InChI=1S/C31H34N6O5S/c1-42-27-7-9-28(10-8-27)43(40,41)37-18-16-36(17-19-37)31(39)25-6-11-29(33-21-25)30(38)34-26-12-14-35(15-13-26)22-24-4-2-23(20-32)3-5-24/h2-11,21,26H,12-19,22H2,1H3,(H,34,38)
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n/an/an/an/a 750n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM327946
PNG
((4-(4- fluorobenzyl)piperazin- 1-yl)(6-(4- pheneth...)
Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N2CCN(CCc3ccccc3)CC2)cc1
Show InChI InChI=1S/C30H34FN5O2/c31-27-9-6-25(7-10-27)23-34-16-20-35(21-17-34)29(37)26-8-11-28(32-22-26)30(38)36-18-14-33(15-19-36)13-12-24-4-2-1-3-5-24/h1-11,22H,12-21,23H2
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n/an/an/an/a 3.00E+3n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM327949
PNG
((4-isopropylpiperazin-1- yl)(6-(4- phenethylpipera...)
Show SMILES CC(C)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)N1CCN(CCc2ccccc2)CC1
Show InChI InChI=1S/C26H35N5O2/c1-21(2)29-16-18-30(19-17-29)25(32)23-8-9-24(27-20-23)26(33)31-14-12-28(13-15-31)11-10-22-6-4-3-5-7-22/h3-9,20-21H,10-19H2,1-2H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM327958
PNG
(N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4- (cyclo...)
Show SMILES O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCN(CC2CCCCC2)CC1
Show InChI InChI=1S/C31H40N6O2/c32-20-24-6-8-26(9-7-24)23-35-14-12-28(13-15-35)34-30(38)29-11-10-27(21-33-29)31(39)37-18-16-36(17-19-37)22-25-4-2-1-3-5-25/h6-11,21,25,28H,1-5,12-19,22-23H2,(H,34,38)
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n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM327960
PNG
(N-(1-benzylpiperidin-4- yl)-5-(4- phenylpiperazine...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc(cn1)C(=O)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C29H33N5O2/c35-28(31-25-13-15-32(16-14-25)22-23-7-3-1-4-8-23)27-12-11-24(21-30-27)29(36)34-19-17-33(18-20-34)26-9-5-2-6-10-26/h1-12,21,25H,13-20,22H2,(H,31,35)
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n/an/an/an/a 3.00E+3n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM327961
PNG
(US10377742, Compound 98 | US9663496, Compound 98 |...)
Show SMILES CCOC(=O)C(N1CCC(CC1)NC(=O)c1ccc(cn1)C(=O)N1CCN(Cc2ccc(F)cc2)CC1)c1ccccc1
Show InChI InChI=1S/C33H38FN5O4/c1-2-43-33(42)30(25-6-4-3-5-7-25)38-16-14-28(15-17-38)36-31(40)29-13-10-26(22-35-29)32(41)39-20-18-37(19-21-39)23-24-8-11-27(34)12-9-24/h3-13,22,28,30H,2,14-21,23H2,1H3,(H,36,40)
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n/an/an/an/a 3.00E+3n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM327962
PNG
(N-(4-(4-cyanobenzyl) cyclohexyl)-6-(4-(4- fluorob...)
Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2cccc(n2)C(=O)NC2CCC(Cc3ccc(cc3)C#N)CC2)cc1
Show InChI InChI=1S/C32H34FN5O2/c33-27-12-8-26(9-13-27)22-37-16-18-38(19-17-37)32(40)30-3-1-2-29(36-30)31(39)35-28-14-10-24(11-15-28)20-23-4-6-25(21-34)7-5-23/h1-9,12-13,24,28H,10-11,14-20,22H2,(H,35,39)
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n/an/an/an/a 7.50E+3n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM327969
PNG
(N2-(1-benzylpiperidin-4- yl)-N5-(biphenyl-3- yl)py...)
Show SMILES O=C(Nc1cccc(c1)-c1ccccc1)c1ccc(nc1)C(=O)NC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C31H30N4O2/c36-30(34-28-13-7-12-25(20-28)24-10-5-2-6-11-24)26-14-15-29(32-21-26)31(37)33-27-16-18-35(19-17-27)22-23-8-3-1-4-9-23/h1-15,20-21,27H,16-19,22H2,(H,33,37)(H,34,36)
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n/an/an/an/a 7.50E+3n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM327992
PNG
(N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- met...)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1
Show InChI InChI=1S/C33H35N5O4/c1-42-29-9-6-25(7-10-29)31(39)26-12-18-38(19-13-26)33(41)27-8-11-30(35-21-27)32(40)36-28-14-16-37(17-15-28)22-24-4-2-23(20-34)3-5-24/h2-11,21,26,28H,12-19,22H2,1H3,(H,36,40)
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n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM327998
PNG
(N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- cya...)
Show SMILES O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N
Show InChI InChI=1S/C32H32N6O3/c33-19-23-1-3-25(4-2-23)22-37-15-11-27(12-16-37)36-31(39)30-10-7-26(21-35-30)32(40)38-17-13-29(14-18-38)41-28-8-5-24(20-34)6-9-28/h1-10,21,27,29H,11-18,22H2,(H,36,39)
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Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328005
PNG
(N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-((4- fl...)
Show SMILES OC(C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(F)cc1
Show InChI InChI=1S/C32H34FN5O3/c33-27-8-5-24(6-9-27)30(39)25-11-17-38(18-12-25)32(41)26-7-10-29(35-20-26)31(40)36-28-13-15-37(16-14-28)21-23-3-1-22(19-34)2-4-23/h1-10,20,25,28,30,39H,11-18,21H2,(H,36,40)
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Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328027
PNG
(N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- cya...)
Show SMILES O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)N1CCC(CC1)Oc1ccc(cc1)C#N
Show InChI InChI=1S/C31H32N6O2/c32-19-23-1-3-25(4-2-23)22-36-15-11-26(12-16-36)35-31(38)30-10-7-27(21-34-30)37-17-13-29(14-18-37)39-28-8-5-24(20-33)6-9-28/h1-10,21,26,29H,11-18,22H2,(H,35,38)
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n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328047
PNG
(N-((cis)-4-(4- methoxyphenoxy) cyclohexyl)-5-(4-(...)
Show SMILES COc1ccc(O[C@@H]2CC[C@@H](CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C32H34F3N3O5/c1-41-24-11-13-27(14-12-24)42-26-9-5-23(6-10-26)37-30(39)29-15-2-21(20-36-29)31(40)38-18-16-28(17-19-38)43-25-7-3-22(4-8-25)32(33,34)35/h2-4,7-8,11-15,20,23,26,28H,5-6,9-10,16-19H2,1H3,(H,37,39)/t23-,26+
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Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328057
PNG
(5-(4-(4- methoxyphenoxy) piperidine-1-carbonyl)- ...)
Show SMILES COc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)N3CCCC3)CC2)cc1
Show InChI InChI=1S/C35H43N5O4/c1-43-30-9-11-31(12-10-30)44-32-16-22-40(23-17-32)35(42)27-6-13-33(36-24-27)34(41)37-28-14-20-38(21-15-28)25-26-4-7-29(8-5-26)39-18-2-3-19-39/h4-13,24,28,32H,2-3,14-23,25H2,1H3,(H,37,41)
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Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328058
PNG
(5-(4-(4-fluorophenoxy) piperidine-1-carbonyl)- N-...)
Show SMILES Fc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)N3CCCC3)CC2)cc1
Show InChI InChI=1S/C34H40FN5O3/c35-27-6-10-30(11-7-27)43-31-15-21-40(22-16-31)34(42)26-5-12-32(36-23-26)33(41)37-28-13-19-38(20-14-28)24-25-3-8-29(9-4-25)39-17-1-2-18-39/h3-12,23,28,31H,1-2,13-22,24H2,(H,37,41)
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n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328059
PNG
(5-(4-(4-cyanophenoxy) piperidine-1-carbonyl)- N-(...)
Show SMILES O=C(NC1CCN(Cc2ccc(cc2)N2CCCC2)CC1)c1ccc(cn1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N
Show InChI InChI=1S/C35H40N6O3/c36-23-26-5-10-31(11-6-26)44-32-15-21-41(22-16-32)35(43)28-7-12-33(37-24-28)34(42)38-29-13-19-39(20-14-29)25-27-3-8-30(9-4-27)40-17-1-2-18-40/h3-12,24,29,32H,1-2,13-22,25H2,(H,38,42)
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n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328060
PNG
(N-((cis)-4-(4-cyano-3- fluorophenoxy) cyclohexyl)...)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)N[C@H]1CC[C@H](CC1)Oc1ccc(C#N)c(F)c1
Show InChI InChI=1S/C33H33FN4O5/c1-42-26-8-2-21(3-9-26)31(39)22-14-16-38(17-15-22)33(41)24-5-13-30(36-20-24)32(40)37-25-6-11-27(12-7-25)43-28-10-4-23(19-35)29(34)18-28/h2-5,8-10,13,18,20,22,25,27H,6-7,11-12,14-17H2,1H3,(H,37,40)/t25-,27+
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n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328071
PNG
(N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(3-(4- cya...)
Show SMILES O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CC(C1)Oc1ccc(cc1)C#N
Show InChI InChI=1S/C30H28N6O3/c31-15-21-1-3-23(4-2-21)18-35-13-11-25(12-14-35)34-29(37)28-10-7-24(17-33-28)30(38)36-19-27(20-36)39-26-8-5-22(16-32)6-9-26/h1-10,17,25,27H,11-14,18-20H2,(H,34,37)
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n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328103
PNG
(N-(1-(3-methoxybenzyl) piperidin-4-yl)-5-(4-(4- (...)
Show SMILES COc1cccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(cc2)S(C)(=O)=O)c1
Show InChI InChI=1S/C32H38N4O6S/c1-41-28-5-3-4-23(20-28)22-35-16-12-25(13-17-35)34-31(37)30-11-6-24(21-33-30)32(38)36-18-14-27(15-19-36)42-26-7-9-29(10-8-26)43(2,39)40/h3-11,20-21,25,27H,12-19,22H2,1-2H3,(H,34,37)
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n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328108
PNG
(N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- (cy...)
Show SMILES O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C34H37N5O5S/c35-21-24-1-3-25(4-2-24)23-38-17-13-27(14-18-38)37-33(40)26-5-12-32(36-22-26)34(41)39-19-15-29(16-20-39)44-28-6-8-30(9-7-28)45(42,43)31-10-11-31/h1-9,12,22,27,29,31H,10-11,13-20,23H2,(H,37,40)
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n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328111
PNG
(6-(4-(4- (cyclopropylsulfonyl) phenoxy)piperidine...)
Show SMILES FC(F)(F)Oc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(cc2)S(=O)(=O)C2CC2)cc1
Show InChI InChI=1S/C34H37F3N4O6S/c35-34(36,37)47-28-4-1-23(2-5-28)22-40-17-13-25(14-18-40)39-32(42)24-3-12-31(38-21-24)33(43)41-19-15-27(16-20-41)46-26-6-8-29(9-7-26)48(44,45)30-10-11-30/h1-9,12,21,25,27,30H,10-11,13-20,22H2,(H,39,42)
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n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328117
PNG
(N-((trans)-3-fluoro-1-(4- (trifluoromethoxy) benz...)
Show SMILES CS(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N[C@@H]2CCN(Cc3ccc(OC(F)(F)F)cc3)C[C@H]2F)cc1
Show InChI InChI=1S/C32H34F4N4O6S/c1-47(43,44)26-9-7-23(8-10-26)45-24-12-16-40(17-13-24)31(42)22-4-11-29(37-18-22)30(41)38-28-14-15-39(20-27(28)33)19-21-2-5-25(6-3-21)46-32(34,35)36/h2-11,18,24,27-28H,12-17,19-20H2,1H3,(H,38,41)/t27-,28-/m1/s1
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n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328121
PNG
(N-(6-(4- acetylphenoxy)pyridin- 3-yl)-5-(4-(4- (me...)
Show SMILES CC(=O)c1ccc(Oc2ccc(NC(=O)c3ccc(cn3)C(=O)N3CCC(CC3)Oc3ccc(cc3)S(C)(=O)=O)cn2)cc1
Show InChI InChI=1S/C32H30N4O7S/c1-21(37)22-3-7-26(8-4-22)43-30-14-6-24(20-34-30)35-31(38)29-13-5-23(19-33-29)32(39)36-17-15-27(16-18-36)42-25-9-11-28(12-10-25)44(2,40)41/h3-14,19-20,27H,15-18H2,1-2H3,(H,35,38)
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n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328135
PNG
(5-(4-(4-fluorophenoxy) piperidine-1-carbonyl)- N-...)
Show SMILES Fc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)cc1
Show InChI InChI=1S/C29H24F2N4O4/c30-20-2-7-23(8-3-20)38-25-13-15-35(16-14-25)29(37)19-1-11-26(32-17-19)28(36)34-22-6-12-27(33-18-22)39-24-9-4-21(31)5-10-24/h1-12,17-18,25H,13-16H2,(H,34,36)
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n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328143
PNG
(N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(3,4- d...)
Show SMILES Fc1ccc(cc1F)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1
Show InChI InChI=1S/C32H31F2N5O3/c33-27-7-5-24(17-28(27)34)30(40)23-9-15-39(16-10-23)32(42)25-6-8-29(36-19-25)31(41)37-26-11-13-38(14-12-26)20-22-3-1-21(18-35)2-4-22/h1-8,17,19,23,26H,9-16,20H2,(H,37,41)
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n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328155
PNG
(N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)-5-(4-(p...)
Show SMILES Cc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3cc(F)cc(F)c3)CC2)cc1
Show InChI InChI=1S/C31H34F2N4O3/c1-21-2-5-27(6-3-21)40-28-10-14-37(15-11-28)31(39)23-4-7-29(34-19-23)30(38)35-26-8-12-36(13-9-26)20-22-16-24(32)18-25(33)17-22/h2-7,16-19,26,28H,8-15,20H2,1H3,(H,35,38)
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n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))		BDBM328159
PNG
(N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)-5-(4-(3...)
Show SMILES Fc1cc(F)cc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(F)c(F)c2)c1
Show InChI InChI=1S/C30H30F4N4O3/c31-21-13-19(14-22(32)15-21)18-37-9-5-23(6-10-37)36-29(39)28-4-1-20(17-35-28)30(40)38-11-7-24(8-12-38)41-25-2-3-26(33)27(34)16-25/h1-4,13-17,23-24H,5-12,18H2,(H,36,39)
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n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...

US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%