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Patent code US9663498

Compile Data Set for Download or QSAR
Found 53 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328390
PNG
(3-(difluoromethyl)-6-fluoro-1-((4-methoxy-3-(4-met...)
Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1cc(C(F)F)c2ccc(F)cc12
Show InChI InChI=1S/C21H22F3N3O3S/c1-25-7-9-26(10-8-25)19-12-15(4-6-20(19)30-2)31(28,29)27-13-17(21(23)24)16-5-3-14(22)11-18(16)27/h3-6,11-13,21H,7-10H2,1-2H3
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n/an/a 0.0660n/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328384
PNG
(3-(difluoromethyl)-5-fluoro-1-((4-methoxy-3-(4-met...)
Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1cc(C(F)F)c2cc(F)ccc12
Show InChI InChI=1S/C21H22F3N3O3S/c1-25-7-9-26(10-8-25)19-12-15(4-6-20(19)30-2)31(28,29)27-13-17(21(23)24)16-11-14(22)3-5-18(16)27/h3-6,11-13,21H,7-10H2,1-2H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328391
PNG
(6-chloro-3-(difluoromethyl)-1-((4-methoxy-3-(piper...)
Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C(F)F)c2ccc(Cl)cc12
Show InChI InChI=1S/C20H20ClF2N3O3S/c1-29-19-5-3-14(11-18(19)25-8-6-24-7-9-25)30(27,28)26-12-16(20(22)23)15-4-2-13(21)10-17(15)26/h2-5,10-12,20,24H,6-9H2,1H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328397
PNG
(6-chloro-3-(difluoromethyl)-1-((3-(4-isopropylpipe...)
Show SMILES COc1ccc(cc1N1CCN(CC1)C(C)C)S(=O)(=O)n1cc(C(F)F)c2ccc(Cl)cc12
Show InChI InChI=1S/C23H26ClF2N3O3S/c1-15(2)27-8-10-28(11-9-27)21-13-17(5-7-22(21)32-3)33(30,31)29-14-19(23(25)26)18-6-4-16(24)12-20(18)29/h4-7,12-15,23H,8-11H2,1-3H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328394
PNG
(3-(difluoromethyl)-6-bromo-1-((4-methoxy-3-(4-meth...)
Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1cc(C(F)F)c2ccc(Br)cc12
Show InChI InChI=1S/C21H22BrF2N3O3S/c1-25-7-9-26(10-8-25)19-12-15(4-6-20(19)30-2)31(28,29)27-13-17(21(23)24)16-5-3-14(22)11-18(16)27/h3-6,11-13,21H,7-10H2,1-2H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328396
PNG
(6-chloro-1-((3-(4-cyclopropylpiperazin-1-yl)-4-met...)
Show SMILES COc1ccc(cc1N1CCN(CC1)C1CC1)S(=O)(=O)n1cc(C(F)F)c2ccc(Cl)cc12
Show InChI InChI=1S/C23H24ClF2N3O3S/c1-32-22-7-5-17(13-21(22)28-10-8-27(9-11-28)16-3-4-16)33(30,31)29-14-19(23(25)26)18-6-2-15(24)12-20(18)29/h2,5-7,12-14,16,23H,3-4,8-11H2,1H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328392
PNG
(3-(difluoromethyl)-6-chloro-1-((4-methoxy-3-(4-met...)
Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1cc(C(F)F)c2ccc(Cl)cc12
Show InChI InChI=1S/C21H22ClF2N3O3S/c1-25-7-9-26(10-8-25)19-12-15(4-6-20(19)30-2)31(28,29)27-13-17(21(23)24)16-5-3-14(22)11-18(16)27/h3-6,11-13,21H,7-10H2,1-2H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328395
PNG
(6-chloro-3-(difluoromethyl)-1-((3-(4-ethylpiperazi...)
Show SMILES CCN1CCN(CC1)c1cc(ccc1OC)S(=O)(=O)n1cc(C(F)F)c2ccc(Cl)cc12
Show InChI InChI=1S/C22H24ClF2N3O3S/c1-3-26-8-10-27(11-9-26)20-13-16(5-7-21(20)31-2)32(29,30)28-14-18(22(24)25)17-6-4-15(23)12-19(17)28/h4-7,12-14,22H,3,8-11H2,1-2H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328400
PNG
(3-(difluoromethyl)-1-((4-methoxy-3-(4-methylpipera...)
Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1cc(C(F)F)c2ccc(cc12)C(F)(F)F
Show InChI InChI=1S/C22H22F5N3O3S/c1-28-7-9-29(10-8-28)19-12-15(4-6-20(19)33-2)34(31,32)30-13-17(21(23)24)16-5-3-14(11-18(16)30)22(25,26)27/h3-6,11-13,21H,7-10H2,1-2H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328380
PNG
(6-chloro-1-((4-methoxy-3-(4-methylpiperazin-1-yl)p...)
Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1ccc2ccc(Cl)cc12
Show InChI InChI=1S/C20H22ClN3O3S/c1-22-9-11-23(12-10-22)19-14-17(5-6-20(19)27-2)28(25,26)24-8-7-15-3-4-16(21)13-18(15)24/h3-8,13-14H,9-12H2,1-2H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328381
PNG
(6-bromo-1-((4-methoxy-3-(4-methylpiperazin-1-yl)ph...)
Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1ccc2ccc(Br)cc12
Show InChI InChI=1S/C20H22BrN3O3S/c1-22-9-11-23(12-10-22)19-14-17(5-6-20(19)27-2)28(25,26)24-8-7-15-3-4-16(21)13-18(15)24/h3-8,13-14H,9-12H2,1-2H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328388
PNG
(3-(difluoromethyl)-5-bromo-1-((4-methoxy-3-(4-meth...)
Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1cc(C(F)F)c2cc(Br)ccc12
Show InChI InChI=1S/C21H22BrF2N3O3S/c1-25-7-9-26(10-8-25)19-12-15(4-6-20(19)30-2)31(28,29)27-13-17(21(23)24)16-11-14(22)3-5-18(16)27/h3-6,11-13,21H,7-10H2,1-2H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328379
PNG
(6-chloro-1-((4-methoxy-3-(piperazin-1-yl)phenyl)su...)
Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1ccc2ccc(Cl)cc12
Show InChI InChI=1S/C19H20ClN3O3S/c1-26-19-5-4-16(13-18(19)22-10-7-21-8-11-22)27(24,25)23-9-6-14-2-3-15(20)12-17(14)23/h2-6,9,12-13,21H,7-8,10-11H2,1H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328386
PNG
(5-chloro-3-(difluoromethyl)-1-((4-methoxy-3-(4-met...)
Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1cc(C(F)F)c2cc(Cl)ccc12
Show InChI InChI=1S/C21H22ClF2N3O3S/c1-25-7-9-26(10-8-25)19-12-15(4-6-20(19)30-2)31(28,29)27-13-17(21(23)24)16-11-14(22)3-5-18(16)27/h3-6,11-13,21H,7-10H2,1-2H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328401
PNG
(3-(difluoromethyl)-1-((3-(4-ethylpiperazin-1-yl)-4...)
Show SMILES CCN1CCN(CC1)c1cc(ccc1OC)S(=O)(=O)n1cc(C(F)F)c2ccc(cc12)C(F)(F)F
Show InChI InChI=1S/C23H24F5N3O3S/c1-3-29-8-10-30(11-9-29)20-13-16(5-7-21(20)34-2)35(32,33)31-14-18(22(24)25)17-6-4-15(12-19(17)31)23(26,27)28/h4-7,12-14,22H,3,8-11H2,1-2H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328389
PNG
(3-(difluoromethyl)-6-fluoro-1-((4-methoxy-3-(piper...)
Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C(F)F)c2ccc(F)cc12
Show InChI InChI=1S/C20H20F3N3O3S/c1-29-19-5-3-14(11-18(19)25-8-6-24-7-9-25)30(27,28)26-12-16(20(22)23)15-4-2-13(21)10-17(15)26/h2-5,10-12,20,24H,6-9H2,1H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328393
PNG
(3-(difluoromethyl)-6-bromo-1-((4-methoxy-3-(pipera...)
Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C(F)F)c2ccc(Br)cc12
Show InChI InChI=1S/C20H20BrF2N3O3S/c1-29-19-5-3-14(11-18(19)25-8-6-24-7-9-25)30(27,28)26-12-16(20(22)23)15-4-2-13(21)10-17(15)26/h2-5,10-12,20,24H,6-9H2,1H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328399
PNG
(3-(difluoromethyl)-1-((4-methoxy-3-(piperazin-1-yl...)
Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C(F)F)c2ccc(cc12)C(F)(F)F
Show InChI InChI=1S/C21H20F5N3O3S/c1-32-19-5-3-14(11-18(19)28-8-6-27-7-9-28)33(30,31)29-12-16(20(22)23)15-4-2-13(10-17(15)29)21(24,25)26/h2-5,10-12,20,27H,6-9H2,1H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328402
PNG
(1-((3-(4-cyclopropylpiperazin-1-yl)-4-methoxypheny...)
Show SMILES COc1ccc(cc1N1CCN(CC1)C1CC1)S(=O)(=O)n1cc(C(F)F)c2ccc(cc12)C(F)(F)F
Show InChI InChI=1S/C24H24F5N3O3S/c1-35-22-7-5-17(13-21(22)31-10-8-30(9-11-31)16-3-4-16)36(33,34)32-14-19(23(25)26)18-6-2-15(12-20(18)32)24(27,28)29/h2,5-7,12-14,16,23H,3-4,8-11H2,1H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328366
PNG
(4-fluoro-1-((4-methoxy-3-(4-methylpiperazin-1-yl)p...)
Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1ccc2c(F)cccc12
Show InChI InChI=1S/C20H22FN3O3S/c1-22-10-12-23(13-11-22)19-14-15(6-7-20(19)27-2)28(25,26)24-9-8-16-17(21)4-3-5-18(16)24/h3-9,14H,10-13H2,1-2H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328408
PNG
(5-fluoro-1-((4-methoxy-3-(piperazin-1-yl)phenyl)su...)
Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C)c2cc(F)ccc12
Show InChI InChI=1S/C20H22FN3O3S/c1-14-13-24(18-5-3-15(21)11-17(14)18)28(25,26)16-4-6-20(27-2)19(12-16)23-9-7-22-8-10-23/h3-6,11-13,22H,7-10H2,1-2H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328412
PNG
(6-chloro-3-ethyl-1-((4-methoxy-3-(piperazin-1-yl)p...)
Show SMILES CCc1cn(c2cc(Cl)ccc12)S(=O)(=O)c1ccc(OC)c(c1)N1CCNCC1
Show InChI InChI=1S/C21H24ClN3O3S/c1-3-15-14-25(19-12-16(22)4-6-18(15)19)29(26,27)17-5-7-21(28-2)20(13-17)24-10-8-23-9-11-24/h4-7,12-14,23H,3,8-11H2,1-2H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328383
PNG
(3-(difluoromethyl)-5-fluoro-1-((4-methoxy-3-(piper...)
Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C(F)F)c2cc(F)ccc12
Show InChI InChI=1S/C20H20F3N3O3S/c1-29-19-5-3-14(11-18(19)25-8-6-24-7-9-25)30(27,28)26-12-16(20(22)23)15-10-13(21)2-4-17(15)26/h2-5,10-12,20,24H,6-9H2,1H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328398
PNG
(6-chloro-1-((3-(4-cyclobutylpiperazin-1-yl)-4-meth...)
Show SMILES COc1ccc(cc1N1CCN(CC1)C1CCC1)S(=O)(=O)n1cc(C(F)F)c2ccc(Cl)cc12
Show InChI InChI=1S/C24H26ClF2N3O3S/c1-33-23-8-6-18(14-22(23)29-11-9-28(10-12-29)17-3-2-4-17)34(31,32)30-15-20(24(26)27)19-7-5-16(25)13-21(19)30/h5-8,13-15,17,24H,2-4,9-12H2,1H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328404
PNG
(5,6-dichloro-3-(difluoromethyl)-1-((4-methoxy-3-(p...)
Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C(F)F)c2cc(Cl)c(Cl)cc12
Show InChI InChI=1S/C20H19Cl2F2N3O3S/c1-30-19-3-2-12(8-18(19)26-6-4-25-5-7-26)31(28,29)27-11-14(20(23)24)13-9-15(21)16(22)10-17(13)27/h2-3,8-11,20,25H,4-7H2,1H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328387
PNG
(5-bromo-3-(difluoromethyl)-1-((4-methoxy-3-(pipera...)
Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C(F)F)c2cc(Br)ccc12
Show InChI InChI=1S/C20H20BrF2N3O3S/c1-29-19-5-3-14(11-18(19)25-8-6-24-7-9-25)30(27,28)26-12-16(20(22)23)15-10-13(21)2-4-17(15)26/h2-5,10-12,20,24H,6-9H2,1H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328382
PNG
(7-fluoro-1-((4-methoxy-3-(piperazin-1-yl)phenyl)su...)
Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1ccc2cccc(F)c12
Show InChI InChI=1S/C19H20FN3O3S/c1-26-18-6-5-15(13-17(18)22-11-8-21-9-12-22)27(24,25)23-10-7-14-3-2-4-16(20)19(14)23/h2-7,10,13,21H,8-9,11-12H2,1H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328407
PNG
(6-bromo-3-(difluoromethyl)-1-((4-methoxy-3-(pipera...)
Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1nc(C(F)F)c2ccc(Br)cc12
Show InChI InChI=1S/C19H19BrF2N4O3S/c1-29-17-5-3-13(11-16(17)25-8-6-23-7-9-25)30(27,28)26-15-10-12(20)2-4-14(15)18(24-26)19(21)22/h2-5,10-11,19,23H,6-9H2,1H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328362
PNG
(1-((4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)sul...)
Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1cc(C#N)c2ccccc12
Show InChI InChI=1S/C21H22N4O3S/c1-23-9-11-24(12-10-23)20-13-17(7-8-21(20)28-2)29(26,27)25-15-16(14-22)18-5-3-4-6-19(18)25/h3-8,13,15H,9-12H2,1-2H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328413
PNG
(6-bromo-3-ethyl-1-((4-methoxy-3-(piperazin-1-yl)ph...)
Show SMILES CCc1cn(c2cc(Br)ccc12)S(=O)(=O)c1ccc(OC)c(c1)N1CCNCC1
Show InChI InChI=1S/C21H24BrN3O3S/c1-3-15-14-25(19-12-16(22)4-6-18(15)19)29(26,27)17-5-7-21(28-2)20(13-17)24-10-8-23-9-11-24/h4-7,12-14,23H,3,8-11H2,1-2H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328411
PNG
(3-ethyl-6-fluoro-1-((4-methoxy-3-(piperazin-1-yl)p...)
Show SMILES CCc1cn(c2cc(F)ccc12)S(=O)(=O)c1ccc(OC)c(c1)N1CCNCC1
Show InChI InChI=1S/C21H24FN3O3S/c1-3-15-14-25(19-12-16(22)4-6-18(15)19)29(26,27)17-5-7-21(28-2)20(13-17)24-10-8-23-9-11-24/h4-7,12-14,23H,3,8-11H2,1-2H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328385
PNG
(5-chloro-3-(difluoromethyl)-1-((4-methoxy-3-(piper...)
Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C(F)F)c2cc(Cl)ccc12
Show InChI InChI=1S/C20H20ClF2N3O3S/c1-29-19-5-3-14(11-18(19)25-8-6-24-7-9-25)30(27,28)26-12-16(20(22)23)15-10-13(21)2-4-17(15)26/h2-5,10-12,20,24H,6-9H2,1H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328409
PNG
(5-chloro-1-((4-methoxy-3-(piperazin-1-yl)phenyl)su...)
Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C)c2cc(Cl)ccc12
Show InChI InChI=1S/C20H22ClN3O3S/c1-14-13-24(18-5-3-15(21)11-17(14)18)28(25,26)16-4-6-20(27-2)19(12-16)23-9-7-22-8-10-23/h3-6,11-13,22H,7-10H2,1-2H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328378
PNG
(6-fluoro-1-((4-methoxy-3-(4-methylpiperazin-1-yl)p...)
Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1ccc2ccc(F)cc12
Show InChI InChI=1S/C20H22FN3O3S/c1-22-9-11-23(12-10-22)19-14-17(5-6-20(19)27-2)28(25,26)24-8-7-15-3-4-16(21)13-18(15)24/h3-8,13-14H,9-12H2,1-2H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328410
PNG
(5-bromo-1-((4-methoxy-3-(piperazin-1-yl)phenyl)sul...)
Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C)c2cc(Br)ccc12
Show InChI InChI=1S/C20H22BrN3O3S/c1-14-13-24(18-5-3-15(21)11-17(14)18)28(25,26)16-4-6-20(27-2)19(12-16)23-9-7-22-8-10-23/h3-6,11-13,22H,7-10H2,1-2H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328364
PNG
(1-(1-((4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)...)
Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1cc(C(C)=O)c2ccccc12
Show InChI InChI=1S/C22H25N3O4S/c1-16(26)19-15-25(20-7-5-4-6-18(19)20)30(27,28)17-8-9-22(29-3)21(14-17)24-12-10-23(2)11-13-24/h4-9,14-15H,10-13H2,1-3H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328363
PNG
(1-(1-((4-methoxy-3-(piperazin-1-yl)phenyl)sulfonyl...)
Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C(C)=O)c2ccccc12
Show InChI InChI=1S/C21H23N3O4S/c1-15(25)18-14-24(19-6-4-3-5-17(18)19)29(26,27)16-7-8-21(28-2)20(13-16)23-11-9-22-10-12-23/h3-8,13-14,22H,9-12H2,1-2H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328365
PNG
(4-fluoro-1-((4-methoxy-3-(piperazin-1-yl)phenyl)su...)
Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1ccc2c(F)cccc12
Show InChI InChI=1S/C19H20FN3O3S/c1-26-19-6-5-14(13-18(19)22-11-8-21-9-12-22)27(24,25)23-10-7-15-16(20)3-2-4-17(15)23/h2-7,10,13,21H,8-9,11-12H2,1H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328406
PNG
(6-chloro-3-(difluoromethyl)-1-((4-methoxy-3-(piper...)
Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1nc(C(F)F)c2ccc(Cl)cc12
Show InChI InChI=1S/C19H19ClF2N4O3S/c1-29-17-5-3-13(11-16(17)25-8-6-23-7-9-25)30(27,28)26-15-10-12(20)2-4-14(15)18(24-26)19(21)22/h2-5,10-11,19,23H,6-9H2,1H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328372
PNG
(5-chloro-1-((4-methoxy-3-(4-methylpiperazin-1-yl)p...)
Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1ccc2cc(Cl)ccc12
Show InChI InChI=1S/C20H22ClN3O3S/c1-22-9-11-23(12-10-22)19-14-17(4-6-20(19)27-2)28(25,26)24-8-7-15-13-16(21)3-5-18(15)24/h3-8,13-14H,9-12H2,1-2H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328377
PNG
(6-fluoro-1-((4-methoxy-3-(piperazin-1-yl)phenyl)su...)
Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1ccc2ccc(F)cc12
Show InChI InChI=1S/C19H20FN3O3S/c1-26-19-5-4-16(13-18(19)22-10-7-21-8-11-22)27(24,25)23-9-6-14-2-3-15(20)12-17(14)23/h2-6,9,12-13,21H,7-8,10-11H2,1H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328403
PNG
(3-(difluoromethyl)-5,6-difluoro-1-((4-methoxy-3-(p...)
Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C(F)F)c2cc(F)c(F)cc12
Show InChI InChI=1S/C20H19F4N3O3S/c1-30-19-3-2-12(8-18(19)26-6-4-25-5-7-26)31(28,29)27-11-14(20(23)24)13-9-15(21)16(22)10-17(13)27/h2-3,8-11,20,25H,4-7H2,1H3
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n/an/a 1.40n/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328371
PNG
(5-chloro-1-((4-methoxy-3-(piperazin-1-yl)phenyl)su...)
Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1ccc2cc(Cl)ccc12
Show InChI InChI=1S/C19H20ClN3O3S/c1-26-19-5-3-16(13-18(19)22-10-7-21-8-11-22)27(24,25)23-9-6-14-12-15(20)2-4-17(14)23/h2-6,9,12-13,21H,7-8,10-11H2,1H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328374
PNG
(5-bromo-1-((4-methoxy-3-(4-methylpiperazin-1-yl)ph...)
Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1ccc2cc(Br)ccc12
Show InChI InChI=1S/C20H22BrN3O3S/c1-22-9-11-23(12-10-22)19-14-17(4-6-20(19)27-2)28(25,26)24-8-7-15-13-16(21)3-5-18(15)24/h3-8,13-14H,9-12H2,1-2H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328361
PNG
(1-((4-methoxy-3-(piperazin-1-yl)phenyl)sulfonyl)-1...)
Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C#N)c2ccccc12
Show InChI InChI=1S/C20H20N4O3S/c1-27-20-7-6-16(12-19(20)23-10-8-22-9-11-23)28(25,26)24-14-15(13-21)17-4-2-3-5-18(17)24/h2-7,12,14,22H,8-11H2,1H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328368
PNG
(1-((4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)sul...)
Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1ccc2c(cccc12)C#N
Show InChI InChI=1S/C21H22N4O3S/c1-23-10-12-24(13-11-23)20-14-17(6-7-21(20)28-2)29(26,27)25-9-8-18-16(15-22)4-3-5-19(18)25/h3-9,14H,10-13H2,1-2H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328373
PNG
(5-bromo-1-((4-methoxy-3-(piperazin-1-yl)phenyl)sul...)
Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1ccc2cc(Br)ccc12
Show InChI InChI=1S/C19H20BrN3O3S/c1-26-19-5-3-16(13-18(19)22-10-7-21-8-11-22)27(24,25)23-9-6-14-12-15(20)2-4-17(14)23/h2-6,9,12-13,21H,7-8,10-11H2,1H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328370
PNG
(5-fluoro-1-((4-methoxy-3-(4-methylpiperazin-1-yl) ...)
Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1ccc2cc(F)ccc12
Show InChI InChI=1S/C20H22FN3O3S/c1-22-9-11-23(12-10-22)19-14-17(4-6-20(19)27-2)28(25,26)24-8-7-15-13-16(21)3-5-18(15)24/h3-8,13-14H,9-12H2,1-2H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328375
PNG
(1-((4-methoxy-3-(piperazin-1-yl)phenyl)sulfonyl)-1...)
Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1ccc2cc(ccc12)C#N
Show InChI InChI=1S/C20H20N4O3S/c1-27-20-5-3-17(13-19(20)23-10-7-22-8-11-23)28(25,26)24-9-6-16-12-15(14-21)2-4-18(16)24/h2-6,9,12-13,22H,7-8,10-11H2,1H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328369
PNG
(5-fluoro-1-((4-methoxy-3-(piperazin-1-yl)phenyl)su...)
Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1ccc2cc(F)ccc12
Show InChI InChI=1S/C19H20FN3O3S/c1-26-19-5-3-16(13-18(19)22-10-7-21-8-11-22)27(24,25)23-9-6-14-12-15(20)2-4-17(14)23/h2-6,9,12-13,21H,7-8,10-11H2,1H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328405
PNG
(3-(difluoromethyl)-6-fluoro-1-((4-methoxy-3-(piper...)
Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1nc(C(F)F)c2ccc(F)cc12
Show InChI InChI=1S/C19H19F3N4O3S/c1-29-17-5-3-13(11-16(17)25-8-6-23-7-9-25)30(27,28)26-15-10-12(20)2-4-14(15)18(24-26)19(21)22/h2-5,10-11,19,23H,6-9H2,1H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328367
PNG
(1-((4-methoxy-3-(piperazin-1-yl)phenyl)sulfonyl)-1...)
Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1ccc2c(cccc12)C#N
Show InChI InChI=1S/C20H20N4O3S/c1-27-20-6-5-16(13-19(20)23-11-8-22-9-12-23)28(25,26)24-10-7-17-15(14-21)3-2-4-18(17)24/h2-7,10,13,22H,8-9,11-12H2,1H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (human))
BDBM328376
PNG
(1-((4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)sul...)
Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1ccc2cc(ccc12)C#N
Show InChI InChI=1S/C21H22N4O3S/c1-23-9-11-24(12-10-23)20-14-18(4-6-21(20)28-2)29(26,27)25-8-7-17-13-16(15-22)3-5-19(17)25/h3-8,13-14H,9-12H2,1-2H3
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SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...


US Patent US9663498 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%