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Patent code US9663508

Compile Data Set for Download or QSAR

Found 431 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
nav 1.7 px


(Homo sapiens (Human))
BDBM329013
PNG
(4-(5-chloro-6-(3-chloro-4- methylphenoxy)-3-pyridi...)
Show SMILES COc1cc(ccc1-c1cnc(Oc2ccc(C)c(Cl)c2)c(Cl)c1)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C21H18Cl2N2O5S/c1-12-4-6-15(10-17(12)22)30-21-18(23)8-14(11-24-21)16-7-5-13(9-19(16)29-2)20(26)25-31(3,27)28/h4-11H,1-3H3,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
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PC sid
UniChem
US Patent
n/an/a 84.7n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329026
PNG
(4-(5-chloro-6-(4-chloro-3- (trifluoromethyl)phenox...)
Show SMILES COc1cc(ccc1-c1cnc(Oc2ccc(Cl)c(c2)C(F)(F)F)c(Cl)c1)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C21H15Cl2F3N2O5S/c1-32-18-8-11(19(29)28-34(2,30)31)3-5-14(18)12-7-17(23)20(27-10-12)33-13-4-6-16(22)15(9-13)21(24,25)26/h3-10H,1-2H3,(H,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
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PC sid
UniChem
US Patent
n/an/a 57n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329031
PNG
(4-(5-chloro-6-(4-chloro-2- fluorophenoxy)-3-pyridi...)
Show SMILES COc1cc(ccc1-c1cnc(Oc2ccc(Cl)cc2F)c(Cl)c1)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C20H15Cl2FN2O5S/c1-29-18-8-11(19(26)25-31(2,27)28)3-5-14(18)12-7-15(22)20(24-10-12)30-17-6-4-13(21)9-16(17)23/h3-10H,1-2H3,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 60.3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329036
PNG
(4-(5-chloro-6-((5-chloro-6- methoxy-3-pyridinyl)ox...)
Show SMILES COc1ncc(Oc2ncc(cc2Cl)-c2ccc(cc2OC2COC2)C(=O)NS(C)(=O)=O)cc1Cl
Show InChI InChI=1S/C22H19Cl2N3O7S/c1-31-21-18(24)7-14(9-26-21)34-22-17(23)5-13(8-25-22)16-4-3-12(20(28)27-35(2,29)30)6-19(16)33-15-10-32-11-15/h3-9,15H,10-11H2,1-2H3,(H,27,28)
PDB

KEGG

UniProtKB/SwissProt

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US Patent
n/an/a 98.9n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329037
PNG
(4-(5-chloro-6-(4-chloro-3- methylphenoxy)-3-pyridi...)
Show SMILES Cc1cc(Oc2ncc(cc2Cl)-c2ccc(cc2OC2COC2)C(=O)NS(C)(=O)=O)ccc1Cl
Show InChI InChI=1S/C23H20Cl2N2O6S/c1-13-7-16(4-6-19(13)24)33-23-20(25)8-15(10-26-23)18-5-3-14(22(28)27-34(2,29)30)9-21(18)32-17-11-31-12-17/h3-10,17H,11-12H2,1-2H3,(H,27,28)
PDB

KEGG

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 46.1n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329046
PNG
(4-(5-chloro-6-(3-chloro-4- methylphenoxy)-3-pyridi...)
Show SMILES Cc1ccc(Oc2ncc(cc2Cl)-c2ccc(cc2OC(F)F)C(=O)NS(C)(=O)=O)cc1Cl
Show InChI InChI=1S/C21H16Cl2F2N2O5S/c1-11-3-5-14(9-16(11)22)31-20-17(23)7-13(10-26-20)15-6-4-12(8-18(15)32-21(24)25)19(28)27-33(2,29)30/h3-10,21H,1-2H3,(H,27,28)
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 79.2n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329052
PNG
(4-(5-chloro-6-(3,4- dimethylphenoxy)-3-pyridinyl)-...)
Show SMILES Cc1ccc(Oc2ncc(cc2Cl)-c2ccc(cc2OC(F)F)C(=O)NS(C)(=O)=O)cc1C
Show InChI InChI=1S/C22H19ClF2N2O5S/c1-12-4-6-16(8-13(12)2)31-21-18(23)9-15(11-26-21)17-7-5-14(10-19(17)32-22(24)25)20(28)27-33(3,29)30/h4-11,22H,1-3H3,(H,27,28)
PDB

KEGG

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 95n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329065
PNG
(4-(5-chloro-6-(2,4-dichloro-6- methylphenoxy)-3-py...)
Show SMILES Cc1cc(Cl)cc(Cl)c1Oc1ncc(cc1Cl)-c1cc(F)c(cc1F)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C20H13Cl3F2N2O4S/c1-9-3-11(21)5-14(22)18(9)31-20-15(23)4-10(8-26-20)12-6-17(25)13(7-16(12)24)19(28)27-32(2,29)30/h3-8H,1-2H3,(H,27,28)
PDB

KEGG

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a>4.90E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329074
PNG
(4-(5-bromo-6-(2,4-dichloro-6- methylphenoxy)-3-pyr...)
Show SMILES Cc1cc(Cl)cc(Cl)c1Oc1ncc(cc1Br)-c1cc(F)c(cc1F)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C20H13BrCl2F2N2O4S/c1-9-3-11(22)5-15(23)18(9)31-20-14(21)4-10(8-26-20)12-6-17(25)13(7-16(12)24)19(28)27-32(2,29)30/h3-8H,1-2H3,(H,27,28)
PDB

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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a>4.90E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329086
PNG
(4-(5-chloro-6-((1R)-2,2,2-trifluoro-1-methyl-1-phe...)
Show SMILES Cc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(O[C@](C)(c2ccccc2)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C23H19ClF4N2O4S/c1-13-9-17(20(31)30-35(3,32)33)19(25)11-16(13)14-10-18(24)21(29-12-14)34-22(2,23(26,27)28)15-7-5-4-6-8-15/h4-12H,1-3H3,(H,30,31)/t22-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a>3.00E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329088
PNG
(5-chloro-4-(5-chloro-6-(2,3,5-trifluorophenoxy)-3-...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(cc1F)-c1cnc(Oc2cc(F)cc(F)c2F)c(Cl)c1
Show InChI InChI=1S/C19H10Cl2F4N2O4S/c1-32(29,30)27-18(28)11-5-12(20)10(6-14(11)23)8-2-13(21)19(26-7-8)31-16-4-9(22)3-15(24)17(16)25/h2-7H,1H3,(H,27,28)
PDB

KEGG

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 49.9n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329089
PNG
(5-chloro-4-(5-chloro-6-(5- chloro-2-methylphenoxy)...)
Show SMILES Cc1ccc(Cl)cc1Oc1ncc(cc1Cl)-c1cc(F)c(cc1Cl)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C20H14Cl3FN2O4S/c1-10-3-4-12(21)6-18(10)30-20-16(23)5-11(9-25-20)13-8-17(24)14(7-15(13)22)19(27)26-31(2,28)29/h3-9H,1-2H3,(H,26,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
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PC cid
PC sid
UniChem
US Patent
n/an/a>3.00E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329090
PNG
(5-chloro-4-(5-chloro-6-(3- fluoro-4-methylphenoxy)...)
Show SMILES Cc1ccc(Oc2ncc(cc2Cl)-c2cc(F)c(cc2Cl)C(=O)NS(C)(=O)=O)cc1F
Show InChI InChI=1S/C20H14Cl2F2N2O4S/c1-10-3-4-12(6-17(10)23)30-20-16(22)5-11(9-25-20)13-8-18(24)14(7-15(13)21)19(27)26-31(2,28)29/h3-9H,1-2H3,(H,26,27)
PDB

KEGG

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 85.6n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329094
PNG
(5-chloro-4-(5-chloro-6-(2- chloro-5-fluorophenoxy)...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(cc1F)-c1cnc(Oc2cc(F)ccc2Cl)c(Cl)c1
Show InChI InChI=1S/C19H11Cl3F2N2O4S/c1-31(28,29)26-18(27)12-6-14(21)11(7-16(12)24)9-4-15(22)19(25-8-9)30-17-5-10(23)2-3-13(17)20/h2-8H,1H3,(H,26,27)
PDB

KEGG

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 81.4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329097
PNG
(5-chloro-4-(5-chloro-6-(2,4-dichloro-6-methylpheno...)
Show SMILES Cc1cc(Cl)cc(Cl)c1Oc1ncc(cc1Cl)-c1cc(F)c(cc1Cl)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C20H13Cl4FN2O4S/c1-9-3-11(21)5-15(23)18(9)31-20-16(24)4-10(8-26-20)12-7-17(25)13(6-14(12)22)19(28)27-32(2,29)30/h3-8H,1-2H3,(H,27,28)
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 18.4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329099
PNG
(5-chloro-4-(5-chloro-6- (cyclopentylmethoxy)-3- py...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(cc1F)-c1cnc(OCC2CCCC2)c(Cl)c1
Show InChI InChI=1S/C19H19Cl2FN2O4S/c1-29(26,27)24-18(25)14-7-15(20)13(8-17(14)22)12-6-16(21)19(23-9-12)28-10-11-4-2-3-5-11/h6-9,11H,2-5,10H2,1H3,(H,24,25)
PDB

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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 91.9n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329106
PNG
(4-(6-(3-bromophenoxy)-5- chloro-3-pyridinyl)-2-flu...)
Show SMILES Cc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2cccc(Br)c2)c(Cl)c1
Show InChI InChI=1S/C20H15BrClFN2O4S/c1-11-6-16(19(26)25-30(2,27)28)18(23)9-15(11)12-7-17(22)20(24-10-12)29-14-5-3-4-13(21)8-14/h3-10H,1-2H3,(H,25,26)
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a>3.00E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329110
PNG
(4-(6-(4-tert-butyl-2- chlorophenoxy)-5-chloro-3- ...)
Show SMILES Cc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2ccc(cc2Cl)C(C)(C)C)c(Cl)c1
Show InChI InChI=1S/C24H23Cl2FN2O4S/c1-13-8-17(22(30)29-34(5,31)32)20(27)11-16(13)14-9-19(26)23(28-12-14)33-21-7-6-15(10-18(21)25)24(2,3)4/h6-12H,1-5H3,(H,29,30)
PDB

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UniProtKB/SwissProt

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US Patent
n/an/a>3.00E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329111
PNG
(4-(6-(2-biphenylyloxy)-5- chloro-3-pyridinyl)-2-fl...)
Show SMILES Cc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2ccccc2-c2ccccc2)c(Cl)c1
Show InChI InChI=1S/C26H20ClFN2O4S/c1-16-12-21(25(31)30-35(2,32)33)23(28)14-20(16)18-13-22(27)26(29-15-18)34-24-11-7-6-10-19(24)17-8-4-3-5-9-17/h3-15H,1-2H3,(H,30,31)
PDB

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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a>3.00E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329115
PNG
(4-(5-chloro-6-(5-chloro-2- methylphenoxy)-3-pyridi...)
Show SMILES Cc1ccc(Cl)cc1Oc1ncc(cc1Cl)-c1cc(F)c(cc1C)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C21H17Cl2FN2O4S/c1-11-4-5-14(22)8-19(11)30-21-17(23)7-13(10-25-21)15-9-18(24)16(6-12(15)2)20(27)26-31(3,28)29/h4-10H,1-3H3,(H,26,27)
PDB

KEGG

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 70.8n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329116
PNG
(4-(5-chloro-6-(5-chloro-2- fluorophenoxy)-3-pyridi...)
Show SMILES Cc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2cc(Cl)ccc2F)c(Cl)c1
Show InChI InChI=1S/C20H14Cl2F2N2O4S/c1-10-5-14(19(27)26-31(2,28)29)17(24)8-13(10)11-6-15(22)20(25-9-11)30-18-7-12(21)3-4-16(18)23/h3-9H,1-2H3,(H,26,27)
PDB

KEGG

UniProtKB/SwissProt

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DrugBank
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PC cid
PC sid
UniChem
US Patent
n/an/a 93.3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329119
PNG
(4-(5-chloro-6-(4-chloro-2- methylphenoxy)-3-pyridi...)
Show SMILES Cc1cc(Cl)ccc1Oc1ncc(cc1Cl)-c1cc(F)c(cc1C)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C21H17Cl2FN2O4S/c1-11-7-16(20(27)26-31(3,28)29)18(24)9-15(11)13-8-17(23)21(25-10-13)30-19-5-4-14(22)6-12(19)2/h4-10H,1-3H3,(H,26,27)
PDB

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US Patent
n/an/a>3.00E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329122
PNG
(4-(5-Chloro-6-(3-Fluoro-4-Methylphenoxy)Pyridin-3-...)
Show SMILES Cc1ccc(Oc2ncc(cc2Cl)-c2cc(F)c(cc2C)C(=O)NS(C)(=O)=O)cc1F
Show InChI InChI=1S/C21H17ClF2N2O4S/c1-11-4-5-14(8-18(11)23)30-21-17(22)7-13(10-25-21)15-9-19(24)16(6-12(15)2)20(27)26-31(3,28)29/h4-10H,1-3H3,(H,26,27)
PDB

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US Patent
n/an/a 4.84E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329123
PNG
(4-(6-(2-tert-butyl-5- methylphenoxy)-5-chloro-3- p...)
Show SMILES Cc1ccc(c(Oc2ncc(cc2Cl)-c2cc(F)c(cc2C)C(=O)NS(C)(=O)=O)c1)C(C)(C)C
Show InChI InChI=1S/C25H26ClFN2O4S/c1-14-7-8-19(25(3,4)5)22(9-14)33-24-20(26)11-16(13-28-24)17-12-21(27)18(10-15(17)2)23(30)29-34(6,31)32/h7-13H,1-6H3,(H,29,30)
PDB

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n/an/a 82.7n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329126
PNG
(4-(5-chloro-6-(2,6- dichlorophenoxy)-3-pyridinyl)-...)
Show SMILES Cc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2c(Cl)cccc2Cl)c(Cl)c1
Show InChI InChI=1S/C20H14Cl3FN2O4S/c1-10-6-13(19(27)26-31(2,28)29)17(24)8-12(10)11-7-16(23)20(25-9-11)30-18-14(21)4-3-5-15(18)22/h3-9H,1-2H3,(H,26,27)
PDB

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n/an/a>3.00E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329136
PNG
(4-(5-chloro-6-(3- methylbutoxy)-3-pyridinyl)-2- fl...)
Show SMILES CC(C)CCOc1ncc(cc1Cl)-c1cc(F)c(cc1C)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C19H22ClFN2O4S/c1-11(2)5-6-27-19-16(20)8-13(10-22-19)14-9-17(21)15(7-12(14)3)18(24)23-28(4,25)26/h7-11H,5-6H2,1-4H3,(H,23,24)
PDB

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n/an/a 87.7n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329143
PNG
(4-(5-chloro-6-(2,6-dichloro-4- fluorophenoxy)-3-py...)
Show SMILES Cc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2c(Cl)cc(F)cc2Cl)c(Cl)c1
Show InChI InChI=1S/C20H13Cl3F2N2O4S/c1-9-3-13(19(28)27-32(2,29)30)17(25)7-12(9)10-4-16(23)20(26-8-10)31-18-14(21)5-11(24)6-15(18)22/h3-8H,1-2H3,(H,27,28)
PDB

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n/an/a 82.8n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329146
PNG
(4-(6-((1R)-1-(1,3-benzothiazol-2-yl)ethoxy)-5-chlo...)
Show SMILES C[C@@H](Oc1ncc(cc1Cl)-c1cc(F)c(cc1C)C(=O)NS(C)(=O)=O)c1nc2ccccc2s1
Show InChI InChI=1S/C23H19ClFN3O4S2/c1-12-8-16(21(29)28-34(3,30)31)18(25)10-15(12)14-9-17(24)22(26-11-14)32-13(2)23-27-19-6-4-5-7-20(19)33-23/h4-11,13H,1-3H3,(H,28,29)/t13-/m1/s1
PDB

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n/an/a>3.00E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329158
PNG
(4-(5-chloro-6-((1R)-1-(2,4,5-trifluorophenyl)ethox...)
Show SMILES C[C@@H](Oc1ncc(cc1Cl)-c1cc(F)c(cc1C)C(=O)NS(C)(=O)=O)c1cc(F)c(F)cc1F
Show InChI InChI=1S/C22H17ClF4N2O4S/c1-10-4-15(21(30)29-34(3,31)32)17(24)6-13(10)12-5-16(23)22(28-9-12)33-11(2)14-7-19(26)20(27)8-18(14)25/h4-9,11H,1-3H3,(H,29,30)/t11-/m1/s1
PDB

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n/an/a 6.44E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329162
PNG
(4-(5-chloro-6-(3,4- dichlorophenoxy)-3-pyridinyl)-...)
Show SMILES Cc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2ccc(Cl)c(Cl)c2)c(Cl)c1
Show InChI InChI=1S/C20H14Cl3FN2O4S/c1-10-5-14(19(27)26-31(2,28)29)18(24)8-13(10)11-6-17(23)20(25-9-11)30-12-3-4-15(21)16(22)7-12/h3-9H,1-2H3,(H,26,27)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329165
PNG
(4-(5-chloro-6-(2,4,5- trichlorophenoxy)-3-pyridiny...)
Show SMILES Cc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2cc(Cl)c(Cl)cc2Cl)c(Cl)c1
Show InChI InChI=1S/C20H13Cl4FN2O4S/c1-9-3-12(19(28)27-32(2,29)30)17(25)5-11(9)10-4-16(24)20(26-8-10)31-18-7-14(22)13(21)6-15(18)23/h3-8H,1-2H3,(H,27,28)
PDB

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n/an/a 50.5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329165
PNG
(4-(5-chloro-6-(2,4,5- trichlorophenoxy)-3-pyridiny...)
Show SMILES Cc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2cc(Cl)c(Cl)cc2Cl)c(Cl)c1
Show InChI InChI=1S/C20H13Cl4FN2O4S/c1-9-3-12(19(28)27-32(2,29)30)17(25)5-11(9)10-4-16(24)20(26-8-10)31-18-7-14(22)13(21)6-15(18)23/h3-8H,1-2H3,(H,27,28)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329172
PNG
(4-(5-chloro-6-((1S)-1-(2,5- dichlorophenyl)ethoxy)...)
Show SMILES C[C@H](Oc1ncc(cc1Cl)-c1cc(F)c(cc1C)C(=O)NS(C)(=O)=O)c1cc(Cl)ccc1Cl
Show InChI InChI=1S/C22H18Cl3FN2O4S/c1-11-6-17(21(29)28-33(3,30)31)20(26)9-15(11)13-7-19(25)22(27-10-13)32-12(2)16-8-14(23)4-5-18(16)24/h4-10,12H,1-3H3,(H,28,29)/t12-/m0/s1
PDB

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n/an/a 83.4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329179
PNG
(4-(5-chloro-6-((4-chloro-2- methylbenzyl)oxy)-3- p...)
Show SMILES Cc1cc(Cl)ccc1COc1ncc(cc1Cl)-c1cc(F)c(cc1C)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C22H19Cl2FN2O4S/c1-12-6-16(23)5-4-14(12)11-31-22-19(24)8-15(10-26-22)17-9-20(25)18(7-13(17)2)21(28)27-32(3,29)30/h4-10H,11H2,1-3H3,(H,27,28)
PDB

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n/an/a>4.90E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329180
PNG
(4-(5-chloro-6-((1S)-1-(1- naphthalenypethoxy)-3- p...)
Show SMILES C[C@H](Oc1ncc(cc1Cl)-c1cc(F)c(cc1C)C(=O)NS(C)(=O)=O)c1cccc2ccccc12
Show InChI InChI=1S/C26H22ClFN2O4S/c1-15-11-22(25(31)30-35(3,32)33)24(28)13-21(15)18-12-23(27)26(29-14-18)34-16(2)19-10-6-8-17-7-4-5-9-20(17)19/h4-14,16H,1-3H3,(H,30,31)/t16-/m0/s1
PDB

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n/an/a 55.1n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329190
PNG
(4-(5-cyano-6-(3,4- dichlorophenoxy)-3-pyridinyl)- ...)
Show SMILES COc1cc(ccc1-c1cnc(Oc2ccc(Cl)c(Cl)c2)c(c1)C#N)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C21H15Cl2N3O5S/c1-30-19-8-12(20(27)26-32(2,28)29)3-5-16(19)14-7-13(10-24)21(25-11-14)31-15-4-6-17(22)18(23)9-15/h3-9,11H,1-2H3,(H,26,27)
PDB

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n/an/a 60.3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329194
PNG
(4-(5-chloro-6-((1R)-1-phenylethoxy)-3-pyridinyl)-2...)
Show SMILES COc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(O[C@H](C)c2ccccc2)c(Cl)c1
Show InChI InChI=1S/C22H20ClFN2O5S/c1-13(14-7-5-4-6-8-14)31-22-18(23)9-15(12-25-22)16-10-19(24)17(11-20(16)30-2)21(27)26-32(3,28)29/h4-13H,1-3H3,(H,26,27)/t13-/m1/s1
PDB

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n/an/a>3.00E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329204
PNG
(4-(5-Chloro-6-(2,5-Difluorophenoxy)Pyridin-3-yl)-2...)
Show SMILES COc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(O[C@H](C)Cc2ccccc2)c(Cl)c1
Show InChI InChI=1S/C23H22ClFN2O5S/c1-14(9-15-7-5-4-6-8-15)32-23-19(24)10-16(13-26-23)17-11-20(25)18(12-21(17)31-2)22(28)27-33(3,29)30/h4-8,10-14H,9H2,1-3H3,(H,27,28)/t14-/m1/s1
PDB

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n/an/a>3.00E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329256
PNG
(4-(5-chloro-6-(2,6-difluoro-3- methylphenoxy)-3-py...)
Show SMILES COc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2c(F)ccc(C)c2F)c(Cl)c1
Show InChI InChI=1S/C21H16ClF3N2O5S/c1-10-4-5-15(23)19(18(10)25)32-21-14(22)6-11(9-26-21)12-7-16(24)13(8-17(12)31-2)20(28)27-33(3,29)30/h4-9H,1-3H3,(H,27,28)
PDB

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n/an/a 95.4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329282
PNG
(4-(6-((1S,2R,4S)- bicyclo[2.2.1]hept-2-yloxy)-5- c...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(OC(F)F)c(cc1F)-c1cnc(O[C@@H]2C[C@H]3CC[C@H]2C3)c(Cl)c1
Show InChI InChI=1S/C21H20ClF3N2O5S/c1-33(29,30)27-19(28)14-8-18(32-21(24)25)13(7-16(14)23)12-6-15(22)20(26-9-12)31-17-5-10-2-3-11(17)4-10/h6-11,17,21H,2-5H2,1H3,(H,27,28)/t10-,11-,17+/m0/s1
PDB

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n/an/a 73.2n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329286
PNG
(4-(5-cyano-6-(2,4-dichloro-6- methylphenoxy)-3-pyr...)
Show SMILES Cc1cc(Cl)cc(Cl)c1Oc1ncc(cc1C#N)-c1cc(F)c(cc1F)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C21H13Cl2F2N3O4S/c1-10-3-13(22)5-16(23)19(10)32-21-11(8-26)4-12(9-27-21)14-6-18(25)15(7-17(14)24)20(29)28-33(2,30)31/h3-7,9H,1-2H3,(H,28,29)
PDB

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n/an/a 78.9n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329297
PNG
(4-(5-chloro-6-(cyclobutyloxy)- 3-pyridinyl)-N- (cy...)
Show SMILES Cc1cc(C(=O)NS(=O)(=O)C2CCC2)c(F)cc1-c1cnc(OC2CCC2)c(Cl)c1
Show InChI InChI=1S/C21H22ClFN2O4S/c1-12-8-17(20(26)25-30(27,28)15-6-3-7-15)19(23)10-16(12)13-9-18(22)21(24-11-13)29-14-4-2-5-14/h8-11,14-15H,2-7H2,1H3,(H,25,26)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a>4.90E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329300
PNG
(4-(5-chloro-6-(2,4-dichloro-6- methylphenoxy)-3-py...)
Show SMILES Cc1cc(Cl)cc(Cl)c1Oc1ncc(cc1Cl)-c1cc(F)c(cc1C)C(=O)NS(=O)(=O)C1CC1
Show InChI InChI=1S/C23H18Cl3FN2O4S/c1-11-6-17(22(30)29-34(31,32)15-3-4-15)20(27)9-16(11)13-7-19(26)23(28-10-13)33-21-12(2)5-14(24)8-18(21)25/h5-10,15H,3-4H2,1-2H3,(H,29,30)
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 56.2n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329306
PNG
(3'-chloro-5-fluoro-2-methyl-N- (methylsulfonyl)-4'...)
Show SMILES Cc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1ccc(c(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C16H12ClF4NO3S/c1-8-5-11(15(23)22-26(2,24)25)14(18)7-10(8)9-3-4-12(13(17)6-9)16(19,20)21/h3-7H,1-2H3,(H,22,23)
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 413n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329318
PNG
(4-(5-chloro-6-((4- cyanophenoxy)methyl)-3- pyridin...)
Show SMILES COc1cc(ccc1-c1cnc(COc2ccc(cc2)C#N)c(Cl)c1)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C22H18ClN3O5S/c1-30-21-10-15(22(27)26-32(2,28)29)5-8-18(21)16-9-19(23)20(25-12-16)13-31-17-6-3-14(11-24)4-7-17/h3-10,12H,13H2,1-2H3,(H,26,27)
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 6.56E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329319
PNG
(4-(5-chloro-6-isobutoxypyridin-3-yl)-3-(2- | 4-(5-...)
Show SMILES COc1nccc(C)c1-c1cc(ccc1-c1cnc(OCC(C)C)c(Cl)c1)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C24H26ClN3O5S/c1-14(2)13-33-23-20(25)11-17(12-27-23)18-7-6-16(22(29)28-34(5,30)31)10-19(18)21-15(3)8-9-26-24(21)32-4/h6-12,14H,13H2,1-5H3,(H,28,29)
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 2.30E+4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329319
PNG
(4-(5-chloro-6-isobutoxypyridin-3-yl)-3-(2- | 4-(5-...)
Show SMILES COc1nccc(C)c1-c1cc(ccc1-c1cnc(OCC(C)C)c(Cl)c1)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C24H26ClN3O5S/c1-14(2)13-33-23-20(25)11-17(12-27-23)18-7-6-16(22(29)28-34(5,30)31)10-19(18)21-15(3)8-9-26-24(21)32-4/h6-12,14H,13H2,1-5H3,(H,28,29)
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 3.20E+4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329330
PNG
(4-(5-(3,5-difluorophenyl)-6-(2- methylpropoxy)-3-p...)
Show SMILES CC(C)COc1ncc(cc1-c1cc(F)cc(F)c1)-c1cc(F)c(cc1F)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C23H20F4N2O4S/c1-12(2)11-33-23-18(13-4-15(24)7-16(25)5-13)6-14(10-28-23)17-8-21(27)19(9-20(17)26)22(30)29-34(3,31)32/h4-10,12H,11H2,1-3H3,(H,29,30)
PDB

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UniProtKB/SwissProt

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US Patent
n/an/a 642n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329333
PNG
(4-(6-(3,5-dichlorophenoxy)-5-methyl-3-pyridinyl)-3...)
Show SMILES COc1cc(ccc1-c1cnc(Oc2cc(Cl)cc(Cl)c2)c(C)c1)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C21H18Cl2N2O5S/c1-12-6-14(11-24-21(12)30-17-9-15(22)8-16(23)10-17)18-5-4-13(7-19(18)29-2)20(26)25-31(3,27)28/h4-11H,1-3H3,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a>3.00E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329014
PNG
(4-(5-chloro-6-(2-chloro-4- methylphenoxy)-3-pyridi...)
Show SMILES COc1cc(ccc1-c1cnc(Oc2ccc(C)cc2Cl)c(Cl)c1)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C21H18Cl2N2O5S/c1-12-4-7-18(16(22)8-12)30-21-17(23)9-14(11-24-21)15-6-5-13(10-19(15)29-2)20(26)25-31(3,27)28/h4-11H,1-3H3,(H,25,26)
PDB

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UniProtKB/SwissProt

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n/an/a 91.5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%