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Patent code US9663508

Compile Data Set for Download or QSAR

Found 431 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
nav 1.7 px


(Homo sapiens (Human))
BDBM329014
PNG
(4-(5-chloro-6-(2-chloro-4- methylphenoxy)-3-pyridi...)
Show SMILES COc1cc(ccc1-c1cnc(Oc2ccc(C)cc2Cl)c(Cl)c1)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C21H18Cl2N2O5S/c1-12-4-7-18(16(22)8-12)30-21-17(23)9-14(11-24-21)15-6-5-13(10-19(15)29-2)20(26)25-31(3,27)28/h4-11H,1-3H3,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 91.5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329026
PNG
(4-(5-chloro-6-(4-chloro-3- (trifluoromethyl)phenox...)
Show SMILES COc1cc(ccc1-c1cnc(Oc2ccc(Cl)c(c2)C(F)(F)F)c(Cl)c1)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C21H15Cl2F3N2O5S/c1-32-18-8-11(19(29)28-34(2,30)31)3-5-14(18)12-7-17(23)20(27-10-12)33-13-4-6-16(22)15(9-13)21(24,25)26/h3-10H,1-2H3,(H,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 57n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329031
PNG
(4-(5-chloro-6-(4-chloro-2- fluorophenoxy)-3-pyridi...)
Show SMILES COc1cc(ccc1-c1cnc(Oc2ccc(Cl)cc2F)c(Cl)c1)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C20H15Cl2FN2O5S/c1-29-18-8-11(19(26)25-31(2,27)28)3-5-14(18)12-7-15(22)20(24-10-12)30-17-6-4-13(21)9-16(17)23/h3-10H,1-2H3,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 60.3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329044
PNG
(4-(5-chloro-6-((5-chloro-6- methoxy-3-pyridinyl)ox...)
Show SMILES COc1ncc(Oc2ncc(cc2Cl)-c2ccc(cc2OC(F)F)C(=O)NS(C)(=O)=O)cc1Cl
Show InChI InChI=1S/C20H15Cl2F2N3O6S/c1-31-18-15(22)7-12(9-26-18)32-19-14(21)5-11(8-25-19)13-4-3-10(6-16(13)33-20(23)24)17(28)27-34(2,29)30/h3-9,20H,1-2H3,(H,27,28)
PDB

KEGG

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 92.2n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329056
PNG
(4-(5-chloro-6-(2- (trifluoromethyl)phenoxy)-3- pyr...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(c(OC(F)F)c1)-c1cnc(Oc2ccccc2C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C21H14ClF5N2O5S/c1-35(31,32)29-18(30)11-6-7-13(17(9-11)34-20(23)24)12-8-15(22)19(28-10-12)33-16-5-3-2-4-14(16)21(25,26)27/h2-10,20H,1H3,(H,29,30)
PDB

KEGG

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 92.4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329057
PNG
(4-(5-chloro-6-(2-chloro-4- methylphenoxy)-3-pyridi...)
Show SMILES Cc1ccc(Oc2ncc(cc2Cl)-c2ccc(cc2OC(F)F)C(=O)NS(C)(=O)=O)c(Cl)c1
Show InChI InChI=1S/C21H16Cl2F2N2O5S/c1-11-3-6-17(15(22)7-11)31-20-16(23)8-13(10-26-20)14-5-4-12(9-18(14)32-21(24)25)19(28)27-33(2,29)30/h3-10,21H,1-2H3,(H,27,28)
PDB

KEGG

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 69.7n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329065
PNG
(4-(5-chloro-6-(2,4-dichloro-6- methylphenoxy)-3-py...)
Show SMILES Cc1cc(Cl)cc(Cl)c1Oc1ncc(cc1Cl)-c1cc(F)c(cc1F)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C20H13Cl3F2N2O4S/c1-9-3-11(21)5-14(22)18(9)31-20-15(23)4-10(8-26-20)12-6-17(25)13(7-16(12)24)19(28)27-32(2,29)30/h3-8H,1-2H3,(H,27,28)
PDB

KEGG

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 59.8n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329074
PNG
(4-(5-bromo-6-(2,4-dichloro-6- methylphenoxy)-3-pyr...)
Show SMILES Cc1cc(Cl)cc(Cl)c1Oc1ncc(cc1Br)-c1cc(F)c(cc1F)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C20H13BrCl2F2N2O4S/c1-9-3-11(22)5-15(23)18(9)31-20-14(21)4-10(8-26-20)12-6-17(25)13(7-16(12)24)19(28)27-32(2,29)30/h3-8H,1-2H3,(H,27,28)
PDB

KEGG

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a>4.90E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329086
PNG
(4-(5-chloro-6-((1R)-2,2,2-trifluoro-1-methyl-1-phe...)
Show SMILES Cc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(O[C@](C)(c2ccccc2)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C23H19ClF4N2O4S/c1-13-9-17(20(31)30-35(3,32)33)19(25)11-16(13)14-10-18(24)21(29-12-14)34-22(2,23(26,27)28)15-7-5-4-6-8-15/h4-12H,1-3H3,(H,30,31)/t22-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 81.5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329089
PNG
(5-chloro-4-(5-chloro-6-(5- chloro-2-methylphenoxy)...)
Show SMILES Cc1ccc(Cl)cc1Oc1ncc(cc1Cl)-c1cc(F)c(cc1Cl)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C20H14Cl3FN2O4S/c1-10-3-4-12(21)6-18(10)30-20-16(23)5-11(9-25-20)13-8-17(24)14(7-15(13)22)19(27)26-31(2,28)29/h3-9H,1-2H3,(H,26,27)
PDB

KEGG

UniProtKB/SwissProt

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DrugBank
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PC sid
UniChem
US Patent
n/an/a>3.00E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329090
PNG
(5-chloro-4-(5-chloro-6-(3- fluoro-4-methylphenoxy)...)
Show SMILES Cc1ccc(Oc2ncc(cc2Cl)-c2cc(F)c(cc2Cl)C(=O)NS(C)(=O)=O)cc1F
Show InChI InChI=1S/C20H14Cl2F2N2O4S/c1-10-3-4-12(6-17(10)23)30-20-16(22)5-11(9-25-20)13-8-18(24)14(7-15(13)21)19(27)26-31(2,28)29/h3-9H,1-2H3,(H,26,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a>3.00E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329096
PNG
(5-chloro-4-(5-chloro-6-(2,5- difluorophenoxy)-3-py...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(cc1F)-c1cnc(Oc2cc(F)ccc2F)c(Cl)c1
Show InChI InChI=1S/C19H11Cl2F3N2O4S/c1-31(28,29)26-18(27)12-6-13(20)11(7-16(12)24)9-4-14(21)19(25-8-9)30-17-5-10(22)2-3-15(17)23/h2-8H,1H3,(H,26,27)
PDB

KEGG

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 5.39E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329099
PNG
(5-chloro-4-(5-chloro-6- (cyclopentylmethoxy)-3- py...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(cc1F)-c1cnc(OCC2CCCC2)c(Cl)c1
Show InChI InChI=1S/C19H19Cl2FN2O4S/c1-29(26,27)24-18(25)14-7-15(20)13(8-17(14)22)12-6-16(21)19(23-9-12)28-10-11-4-2-3-5-11/h6-9,11H,2-5,10H2,1H3,(H,24,25)
PDB

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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 91.9n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329105
PNG
(4-(6-(4-bromo-2-chloro-5- fluorophenoxy)-5-chloro-...)
Show SMILES Cc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2cc(F)c(Br)cc2Cl)c(Cl)c1
Show InChI InChI=1S/C20H13BrCl2F2N2O4S/c1-9-3-12(19(28)27-32(2,29)30)16(24)5-11(9)10-4-15(23)20(26-8-10)31-18-7-17(25)13(21)6-14(18)22/h3-8H,1-2H3,(H,27,28)
PDB

KEGG

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 71.7n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329106
PNG
(4-(6-(3-bromophenoxy)-5- chloro-3-pyridinyl)-2-flu...)
Show SMILES Cc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2cccc(Br)c2)c(Cl)c1
Show InChI InChI=1S/C20H15BrClFN2O4S/c1-11-6-16(19(26)25-30(2,27)28)18(23)9-15(11)12-7-17(22)20(24-10-12)29-14-5-3-4-13(21)8-14/h3-10H,1-2H3,(H,25,26)
PDB

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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a>3.00E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329110
PNG
(4-(6-(4-tert-butyl-2- chlorophenoxy)-5-chloro-3- ...)
Show SMILES Cc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2ccc(cc2Cl)C(C)(C)C)c(Cl)c1
Show InChI InChI=1S/C24H23Cl2FN2O4S/c1-13-8-17(22(30)29-34(5,31)32)20(27)11-16(13)14-9-19(26)23(28-12-14)33-21-7-6-15(10-18(21)25)24(2,3)4/h6-12H,1-5H3,(H,29,30)
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a>3.00E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329112
PNG
(4-(5-chloro-6-((4-chloro-1- naphthalenyl)oxy)-3-py...)
Show SMILES Cc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2ccc(Cl)c3ccccc23)c(Cl)c1
Show InChI InChI=1S/C24H17Cl2FN2O4S/c1-13-9-18(23(30)29-34(2,31)32)21(27)11-17(13)14-10-20(26)24(28-12-14)33-22-8-7-19(25)15-5-3-4-6-16(15)22/h3-12H,1-2H3,(H,29,30)
PDB

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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 92.7n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329118
PNG
(4-(5-chloro-6-(3-chloro-2- fluorophenoxy)-3-pyridi...)
Show SMILES Cc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2cccc(Cl)c2F)c(Cl)c1
Show InChI InChI=1S/C20H14Cl2F2N2O4S/c1-10-6-13(19(27)26-31(2,28)29)16(23)8-12(10)11-7-15(22)20(25-9-11)30-17-5-3-4-14(21)18(17)24/h3-9H,1-2H3,(H,26,27)
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a>3.00E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329124
PNG
(4-(5-chloro-6-(3-chloro-2,6- difluorophenoxy)-3-py...)
Show SMILES Cc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2c(F)ccc(Cl)c2F)c(Cl)c1
Show InChI InChI=1S/C20H13Cl2F3N2O4S/c1-9-5-12(19(28)27-32(2,29)30)16(24)7-11(9)10-6-14(22)20(26-8-10)31-18-15(23)4-3-13(21)17(18)25/h3-8H,1-2H3,(H,27,28)
PDB

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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 83.7n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329126
PNG
(4-(5-chloro-6-(2,6- dichlorophenoxy)-3-pyridinyl)-...)
Show SMILES Cc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2c(Cl)cccc2Cl)c(Cl)c1
Show InChI InChI=1S/C20H14Cl3FN2O4S/c1-10-6-13(19(27)26-31(2,28)29)17(24)8-12(10)11-7-16(23)20(25-9-11)30-18-14(21)4-3-5-15(18)22/h3-9H,1-2H3,(H,26,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
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PC cid
PC sid
UniChem
US Patent
n/an/a 69.1n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329135
PNG
(4-(6-(1,3-benzothiazol-2- ylmethoxy)-5-chloro-3- p...)
Show SMILES Cc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(OCc2nc3ccccc3s2)c(Cl)c1
Show InChI InChI=1S/C22H17ClFN3O4S2/c1-12-7-15(21(28)27-33(2,29)30)17(24)9-14(12)13-8-16(23)22(25-10-13)31-11-20-26-18-5-3-4-6-19(18)32-20/h3-10H,11H2,1-2H3,(H,27,28)
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a>3.00E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329143
PNG
(4-(5-chloro-6-(2,6-dichloro-4- fluorophenoxy)-3-py...)
Show SMILES Cc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2c(Cl)cc(F)cc2Cl)c(Cl)c1
Show InChI InChI=1S/C20H13Cl3F2N2O4S/c1-9-3-13(19(28)27-32(2,29)30)17(25)7-12(9)10-4-16(23)20(26-8-10)31-18-14(21)5-11(24)6-15(18)22/h3-8H,1-2H3,(H,27,28)
PDB

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US Patent
n/an/a 82.8n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329143
PNG
(4-(5-chloro-6-(2,6-dichloro-4- fluorophenoxy)-3-py...)
Show SMILES Cc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2c(Cl)cc(F)cc2Cl)c(Cl)c1
Show InChI InChI=1S/C20H13Cl3F2N2O4S/c1-9-3-13(19(28)27-32(2,29)30)17(25)7-12(9)10-4-16(23)20(26-8-10)31-18-14(21)5-11(24)6-15(18)22/h3-8H,1-2H3,(H,27,28)
PDB

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US Patent
n/an/a>3.00E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329152
PNG
(4-(5-chloro-6-(5- quinolinylmethoxy)-3- pyridinyl)...)
Show SMILES Cc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(OCc2cccc3ncccc23)c(Cl)c1
Show InChI InChI=1S/C24H19ClFN3O4S/c1-14-9-19(23(30)29-34(2,31)32)21(26)11-18(14)16-10-20(25)24(28-12-16)33-13-15-5-3-7-22-17(15)6-4-8-27-22/h3-12H,13H2,1-2H3,(H,29,30)
PDB

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US Patent
n/an/a 90.4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329167
PNG
(4-(5-chloro-6-(4-chloro-2,6- dimethylphenoxy)-3-py...)
Show SMILES Cc1cc(Cl)cc(C)c1Oc1ncc(cc1Cl)-c1cc(F)c(cc1C)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C22H19Cl2FN2O4S/c1-11-7-17(21(28)27-32(4,29)30)19(25)9-16(11)14-8-18(24)22(26-10-14)31-20-12(2)5-15(23)6-13(20)3/h5-10H,1-4H3,(H,27,28)
PDB

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US Patent
n/an/a 3.61E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329168
PNG
(4-(5-chloro-6-(6-chloro-2- fluoro-3-methylphenoxy)...)
Show SMILES Cc1ccc(Cl)c(Oc2ncc(cc2Cl)-c2cc(F)c(cc2C)C(=O)NS(C)(=O)=O)c1F
Show InChI InChI=1S/C21H16Cl2F2N2O4S/c1-10-4-5-15(22)19(18(10)25)31-21-16(23)7-12(9-26-21)13-8-17(24)14(6-11(13)2)20(28)27-32(3,29)30/h4-9H,1-3H3,(H,27,28)
PDB

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US Patent
n/an/a 83.6n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329169
PNG
(4-(5-chloro-6-(3-fluoro-4- (trifluoromethyl)phenox...)
Show SMILES Cc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2ccc(c(F)c2)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C21H14ClF5N2O4S/c1-10-5-14(19(30)29-34(2,31)32)17(23)8-13(10)11-6-16(22)20(28-9-11)33-12-3-4-15(18(24)7-12)21(25,26)27/h3-9H,1-2H3,(H,29,30)
PDB

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n/an/a 123n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329170
PNG
(4-(5-chloro-6-((7-fluoro-2,3- dihydro-1H-inden-4-y...)
Show SMILES Cc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2ccc(F)c3CCCc23)c(Cl)c1
Show InChI InChI=1S/C23H19ClF2N2O4S/c1-12-8-17(22(29)28-33(2,30)31)20(26)10-16(12)13-9-18(24)23(27-11-13)32-21-7-6-19(25)14-4-3-5-15(14)21/h6-11H,3-5H2,1-2H3,(H,28,29)
PDB

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US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329171
PNG
(4-(5-chloro-6-((1R)-1-(2,5-dichlorophenyl)ethoxy)-...)
Show SMILES C[C@@H](Oc1ncc(cc1Cl)-c1cc(F)c(cc1C)C(=O)NS(C)(=O)=O)c1cc(Cl)ccc1Cl
Show InChI InChI=1S/C22H18Cl3FN2O4S/c1-11-6-17(21(29)28-33(3,30)31)20(26)9-15(11)13-7-19(25)22(27-10-13)32-12(2)16-8-14(23)4-5-18(16)24/h4-10,12H,1-3H3,(H,28,29)/t12-/m1/s1
PDB

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n/an/a 46.2n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329184
PNG
(4-(5-chloro-6-(2,2,2-trifluoro-1- (trifluoromethyl...)
Show SMILES Cc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(OC(C(F)(F)F)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C17H12ClF7N2O4S/c1-7-3-10(13(28)27-32(2,29)30)12(19)5-9(7)8-4-11(18)14(26-6-8)31-15(16(20,21)22)17(23,24)25/h3-6,15H,1-2H3,(H,27,28)
PDB

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n/an/a 115n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329188
PNG
(4-(6-(3-chloro-2-methylphenoxy)-5-cyano-3-pyridiny...)
Show SMILES COc1cc(ccc1-c1cnc(Oc2cccc(Cl)c2C)c(c1)C#N)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C22H18ClN3O5S/c1-13-18(23)5-4-6-19(13)31-22-15(11-24)9-16(12-25-22)17-8-7-14(10-20(17)30-2)21(27)26-32(3,28)29/h4-10,12H,1-3H3,(H,26,27)
PDB

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n/an/a 46.9n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329200
PNG
(4-(5-chloro-6-(cyclobutyloxy)-3-pyridinyl)-2-fluor...)
Show SMILES COc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(OC2CCC2)c(Cl)c1
Show InChI InChI=1S/C18H18ClFN2O5S/c1-26-16-8-13(17(23)22-28(2,24)25)15(20)7-12(16)10-6-14(19)18(21-9-10)27-11-4-3-5-11/h6-9,11H,3-5H2,1-2H3,(H,22,23)
PDB

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n/an/a>4.90E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329211
PNG
(4-(5-chloro-6-((1- methylcyclohexyl)methoxy)-3- py...)
Show SMILES COc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(OCC2(C)CCCCC2)c(Cl)c1
Show InChI InChI=1S/C22H26ClFN2O5S/c1-22(7-5-4-6-8-22)13-31-21-17(23)9-14(12-25-21)15-10-18(24)16(11-19(15)30-2)20(27)26-32(3,28)29/h9-12H,4-8,13H2,1-3H3,(H,26,27)
PDB

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n/an/a 98.6n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329215
PNG
(4-(5-chloro-6-((2,2,3,3- tetramethylcyclopropyl)me...)
Show SMILES COc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(OCC2C(C)(C)C2(C)C)c(Cl)c1
Show InChI InChI=1S/C22H26ClFN2O5S/c1-21(2)18(22(21,3)4)11-31-20-15(23)7-12(10-25-20)13-8-16(24)14(9-17(13)30-5)19(27)26-32(6,28)29/h7-10,18H,11H2,1-6H3,(H,26,27)
PDB

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n/an/a 145n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329218
PNG
(4-(5-chloro-6-(((4,4- dimethylcyclohexyl)methyl)am...)
Show SMILES COc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(NCC2CCC(C)(C)CC2)c(Cl)c1
Show InChI InChI=1S/C23H29ClFN3O4S/c1-23(2)7-5-14(6-8-23)12-26-21-18(24)9-15(13-27-21)16-10-19(25)17(11-20(16)32-3)22(29)28-33(4,30)31/h9-11,13-14H,5-8,12H2,1-4H3,(H,26,27)(H,28,29)
PDB

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n/an/a 87.2n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329225
PNG
(4-(5-chloro-6-((4- methylphenyl)sulfanyl)-3- pyrid...)
Show SMILES COc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Sc2ccc(C)cc2)c(Cl)c1
Show InChI InChI=1S/C21H18ClFN2O4S2/c1-12-4-6-14(7-5-12)30-21-17(22)8-13(11-24-21)15-9-18(23)16(10-19(15)29-2)20(26)25-31(3,27)28/h4-11H,1-3H3,(H,25,26)
PDB

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n/an/a 49.5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329232
PNG
(4-(5-chloro-6-((trans-3-methylcyclobutyl)oxy)-3-py...)
Show SMILES COc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(O[C@H]2C[C@H](C)C2)c(Cl)c1
Show InChI InChI=1S/C19H20ClFN2O5S/c1-10-4-12(5-10)28-19-15(20)6-11(9-22-19)13-7-16(21)14(8-17(13)27-2)18(24)23-29(3,25)26/h6-10,12H,4-5H2,1-3H3,(H,23,24)/t10-,12-
PDB

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n/an/a 59.1n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329251
PNG
(4-(5-chloro-6-(4-fluoro-3- methylphenoxy)-3-pyridi...)
Show SMILES COc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2ccc(F)c(C)c2)c(Cl)c1
Show InChI InChI=1S/C21H17ClF2N2O5S/c1-11-6-13(4-5-17(11)23)31-21-16(22)7-12(10-25-21)14-8-18(24)15(9-19(14)30-2)20(27)26-32(3,28)29/h4-10H,1-3H3,(H,26,27)
PDB

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n/an/a 92.2n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329254
PNG
(4-(5-chloro-6-((7-fluoro-2,3- dihydro-1H-inden-4-y...)
Show SMILES COc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2ccc(F)c3CCCc23)c(Cl)c1
Show InChI InChI=1S/C23H19ClF2N2O5S/c1-32-21-10-16(22(29)28-34(2,30)31)19(26)9-15(21)12-8-17(24)23(27-11-12)33-20-7-6-18(25)13-4-3-5-14(13)20/h6-11H,3-5H2,1-2H3,(H,28,29)
PDB

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n/an/a 47.7n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329271
PNG
(4-(5-chloro-6-((3,4- dichlorophenoxy)methyl)-3- py...)
Show SMILES COc1cc(ccc1-c1cnc(COc2ccc(Cl)c(Cl)c2)c(Cl)c1)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C21H17Cl3N2O5S/c1-30-20-8-12(21(27)26-32(2,28)29)3-5-15(20)13-7-18(24)19(25-10-13)11-31-14-4-6-16(22)17(23)9-14/h3-10H,11H2,1-2H3,(H,26,27)
PDB

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n/an/a 80.1n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329277
PNG
(4-(5-chloro-6-(3-chloro-2- methylphenoxy)-3-pyridi...)
Show SMILES Cc1c(Cl)cccc1Oc1ncc(cc1Cl)-c1cc(F)c(cc1OC(F)F)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C21H15Cl2F3N2O5S/c1-10-14(22)4-3-5-17(10)32-20-15(23)6-11(9-27-20)12-7-16(24)13(8-18(12)33-21(25)26)19(29)28-34(2,30)31/h3-9,21H,1-2H3,(H,28,29)
PDB

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n/an/a 44.5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329289
PNG
(4-(5-chloro-6-(cyclobutyloxy)- 3-pyridinyl)-N-(eth...)
Show SMILES CCS(=O)(=O)NC(=O)c1ccc(c(OC)c1)-c1cnc(OC2CCC2)c(Cl)c1
Show InChI InChI=1S/C19H21ClN2O5S/c1-3-28(24,25)22-18(23)12-7-8-15(17(10-12)26-2)13-9-16(20)19(21-11-13)27-14-5-4-6-14/h7-11,14H,3-6H2,1-2H3,(H,22,23)
PDB

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n/an/a 123n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329297
PNG
(4-(5-chloro-6-(cyclobutyloxy)- 3-pyridinyl)-N- (cy...)
Show SMILES Cc1cc(C(=O)NS(=O)(=O)C2CCC2)c(F)cc1-c1cnc(OC2CCC2)c(Cl)c1
Show InChI InChI=1S/C21H22ClFN2O4S/c1-12-8-17(20(26)25-30(27,28)15-6-3-7-15)19(23)10-16(12)13-9-18(22)21(24-11-13)29-14-4-2-5-14/h8-11,14-15H,2-7H2,1H3,(H,25,26)
PDB

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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 73.9n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329298
PNG
(4-(5-chloro-6-(2,4-dichloro-6- methylphenoxy)-3-py...)
Show SMILES Cc1cc(Cl)cc(Cl)c1Oc1ncc(cc1Cl)-c1cc(F)c(cc1C)C(=O)NS(=O)(=O)c1nccs1
Show InChI InChI=1S/C23H15Cl3FN3O4S2/c1-11-6-16(21(31)30-36(32,33)23-28-3-4-35-23)19(27)9-15(11)13-7-18(26)22(29-10-13)34-20-12(2)5-14(24)8-17(20)25/h3-10H,1-2H3,(H,30,31)
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 23.1n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329298
PNG
(4-(5-chloro-6-(2,4-dichloro-6- methylphenoxy)-3-py...)
Show SMILES Cc1cc(Cl)cc(Cl)c1Oc1ncc(cc1Cl)-c1cc(F)c(cc1C)C(=O)NS(=O)(=O)c1nccs1
Show InChI InChI=1S/C23H15Cl3FN3O4S2/c1-11-6-16(21(31)30-36(32,33)23-28-3-4-35-23)19(27)9-15(11)13-7-18(26)22(29-10-13)34-20-12(2)5-14(24)8-17(20)25/h3-10H,1-2H3,(H,30,31)
PDB

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UniProtKB/SwissProt

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US Patent
n/an/a 669n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329299
PNG
(4-(5-chloro-6-(2,4-dichloro-6- methylphenoxy)-3-py...)
Show SMILES CCS(=O)(=O)NC(=O)c1cc(C)c(cc1F)-c1cnc(Oc2c(C)cc(Cl)cc2Cl)c(Cl)c1
Show InChI InChI=1S/C22H18Cl3FN2O4S/c1-4-33(30,31)28-21(29)16-6-11(2)15(9-19(16)26)13-7-18(25)22(27-10-13)32-20-12(3)5-14(23)8-17(20)24/h5-10H,4H2,1-3H3,(H,28,29)
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 96n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329299
PNG
(4-(5-chloro-6-(2,4-dichloro-6- methylphenoxy)-3-py...)
Show SMILES CCS(=O)(=O)NC(=O)c1cc(C)c(cc1F)-c1cnc(Oc2c(C)cc(Cl)cc2Cl)c(Cl)c1
Show InChI InChI=1S/C22H18Cl3FN2O4S/c1-4-33(30,31)28-21(29)16-6-11(2)15(9-19(16)26)13-7-18(25)22(27-10-13)32-20-12(3)5-14(23)8-17(20)24/h5-10H,4H2,1-3H3,(H,28,29)
PDB

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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 1.25E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329301
PNG
(4-(5-chloro-6-(cyclobutyloxy)- 3-pyridinyl)-5-cycl...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(cc1F)-c1cnc(OC2CCC2)c(Cl)c1
Show InChI InChI=1S/C20H20ClFN2O4S/c1-29(26,27)24-19(25)16-8-14(11-5-6-11)15(9-18(16)22)12-7-17(21)20(23-10-12)28-13-3-2-4-13/h7-11,13H,2-6H2,1H3,(H,24,25)
PDB

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UniProtKB/SwissProt

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US Patent
n/an/a 136n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.5 iwq


(Homo sapiens (Human))
BDBM329303
PNG
(4-(5-chloro-6-((1S)-2,2,2- trifluoro-1-methyl-1- p...)
Show SMILES C[C@](Oc1ncc(cc1Cl)-c1cc(F)c(cc1F)C(=O)NS(C)(=O)=O)(c1ccccc1)C(F)(F)F
Show InChI InChI=1S/C22H16ClF5N2O4S/c1-21(22(26,27)28,13-6-4-3-5-7-13)34-20-16(23)8-12(11-29-20)14-9-18(25)15(10-17(14)24)19(31)30-35(2,32)33/h3-11H,1-2H3,(H,30,31)/t21-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

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US Patent
n/an/a>3.00E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
nav 1.7 px


(Homo sapiens (Human))
BDBM329311
PNG
(5-fluoro-2-methyl-N- (methylsulfonyl)-3'-(1,1,2,2-...)
Show SMILES Cc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cccc(OC(F)(F)C(F)F)c1
Show InChI InChI=1S/C17H14F5NO4S/c1-9-6-13(15(24)23-28(2,25)26)14(18)8-12(9)10-4-3-5-11(7-10)27-17(21,22)16(19)20/h3-8,16H,1-2H3,(H,23,24)
PDB

KEGG

UniProtKB/SwissProt

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US Patent
n/an/a 5.84E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...


US Patent US9663508 (2017)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%