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Patent code US9663513

Compile Data Set for Download or QSAR

Found 257 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329513
PNG
(2-(4-methyl-5-(2-methyl-4- (((1S,2S)-2-(quinolin-2...)
Show SMILES Cc1ncc(c(OC[C@H]2CC2c2ccc3ccccc3n2)n1)-c1cnc(cc1C)C(C)(C)O
Show InChI InChI=1S/C27H28N4O2/c1-16-11-25(27(3,4)32)29-13-21(16)22-14-28-17(2)30-26(22)33-15-19-12-20(19)24-10-9-18-7-5-6-8-23(18)31-24/h5-11,13-14,19-20,32H,12,15H2,1-4H3/t19-,20?/m1/s1
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0n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329542
PNG
(2-((1S,2S)-2-((2-methyl- 5-(pyridin-3- yl)pyrimidi...)
Show SMILES Cc1ncc(c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1)-c1cccnc1
Show InChI InChI=1S/C23H20N4O/c1-15-25-13-20(17-6-4-10-24-12-17)23(26-15)28-14-18-11-19(18)22-9-8-16-5-2-3-7-21(16)27-22/h2-10,12-13,18-19H,11,14H2,1H3/t18-,19+/m1/s1
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0.0100n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329541
PNG
((5-(2-methyl-4-(((1S,2S)- 2-(quinolin-2- yl)cyclop...)
Show SMILES Cc1ncc(-c2ccc(CO)nc2)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1
Show InChI InChI=1S/C24H22N4O2/c1-15-25-12-21(17-6-8-19(13-29)26-11-17)24(27-15)30-14-18-10-20(18)23-9-7-16-4-2-3-5-22(16)28-23/h2-9,11-12,18,20,29H,10,13-14H2,1H3/t18-,20+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329421
PNG
(1-(4-(2-methyl-4- (((1S,2S)-2-(quinolin-2- yl)cycl...)
Show SMILES CC(O)c1ccc(cc1)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc2ccccc2n1
Show InChI InChI=1S/C26H25N3O2/c1-16(30)18-7-9-19(10-8-18)23-14-27-17(2)28-26(23)31-15-21-13-22(21)25-12-11-20-5-3-4-6-24(20)29-25/h3-12,14,16,21-22,30H,13,15H2,1-2H3/t16?,21-,22+/m1/s1
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0.0100n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329409
PNG
(4-(2-methyl-4- (((1S,2S)-2-(quinolin-2- yl)cyclopr...)
Show SMILES Cc1ncc(c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H21N3O3/c1-15-26-13-21(16-6-8-18(9-7-16)25(29)30)24(27-15)31-14-19-12-20(19)23-11-10-17-4-2-3-5-22(17)28-23/h2-11,13,19-20H,12,14H2,1H3,(H,29,30)/t19-,20+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329540
PNG
(2-((1S,2S)-2-((2-methyl- 5-(2-methylpyridin-4- yl)...)
Show SMILES Cc1cc(ccn1)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc2ccccc2n1
Show InChI InChI=1S/C24H22N4O/c1-15-11-18(9-10-25-15)21-13-26-16(2)27-24(21)29-14-19-12-20(19)23-8-7-17-5-3-4-6-22(17)28-23/h3-11,13,19-20H,12,14H2,1-2H3/t19-,20+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329579
PNG
(Trans-4-(2-methyl-4- (((1S,2R)-2-(quinolin-2- yl)c...)
Show SMILES Cc1ncc([C@H]2CC[C@H](O)CC2)c(OC[C@H]2C[C@H]2c2ccc3ccccc3n2)n1
Show InChI InChI=1S/C24H27N3O2/c1-15-25-13-21(16-6-9-19(28)10-7-16)24(26-15)29-14-18-12-20(18)23-11-8-17-4-2-3-5-22(17)27-23/h2-5,8,11,13,16,18-20,28H,6-7,9-10,12,14H2,1H3/t16-,18-,19-,20-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329544
PNG
(2-(5-(2-methyl-4- (((1S,2S)-2-(quinolin-2- yl)cycl...)
Show SMILES Cc1ncc(-c2ccc(nc2)C(C)(C)O)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1
Show InChI InChI=1S/C26H26N4O2/c1-16-27-14-21(18-9-11-24(28-13-18)26(2,3)31)25(29-16)32-15-19-12-20(19)23-10-8-17-6-4-5-7-22(17)30-23/h4-11,13-14,19-20,31H,12,15H2,1-3H3/t19-,20+/m1/s1
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0.0200n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329429
PNG
(2-((1S,2S)-2-((2- methyl-5-(6- methylpyridin-3- yl...)
Show SMILES Cc1ccc(cn1)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc2ccccc2n1
Show InChI InChI=1S/C24H22N4O/c1-15-7-8-18(12-25-15)21-13-26-16(2)27-24(21)29-14-19-11-20(19)23-10-9-17-5-3-4-6-22(17)28-23/h3-10,12-13,19-20H,11,14H2,1-2H3/t19-,20+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329516
PNG
(2-((1S,2S)-2-((2-methyl-5- (3-methylimidazo[1,2- a...)
Show SMILES Cc1cnc2ccc(cn12)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc2ccccc2n1
Show InChI InChI=1S/C26H23N5O/c1-16-12-28-25-10-8-19(14-31(16)25)22-13-27-17(2)29-26(22)32-15-20-11-21(20)24-9-7-18-5-3-4-6-23(18)30-24/h3-10,12-14,20-21H,11,15H2,1-2H3/t20-,21+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329413
PNG
(2-((1S,2S)-2-((2- methyl-5-(pyridin-4- yl)pyrimidi...)
Show SMILES Cc1ncc(c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1)-c1ccncc1
Show InChI InChI=1S/C23H20N4O/c1-15-25-13-20(16-8-10-24-11-9-16)23(26-15)28-14-18-12-19(18)22-7-6-17-4-2-3-5-21(17)27-22/h2-11,13,18-19H,12,14H2,1H3/t18-,19+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329538
PNG
(2-((1S,2S)-2-((2-methyl- 5-(1H-pyrazolo[3,4- b]pyr...)
Show SMILES Cc1ncc(-c2cnc3[nH]ncc3c2)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1
Show InChI InChI=1S/C24H20N6O/c1-14-25-12-20(16-8-17-11-27-30-23(17)26-10-16)24(28-14)31-13-18-9-19(18)22-7-6-15-4-2-3-5-21(15)29-22/h2-8,10-12,18-19H,9,13H2,1H3,(H,26,27,30)/t18-,19+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329432
PNG
(2-(4-Methyl-5-(2-methyl- 4-(((1S,2S)-2-(5- methylp...)
Show SMILES Cc1ccc(nc1)C1C[C@@H]1COc1nc(C)ncc1-c1cnc(cc1C)C(C)(C)O
Show InChI InChI=1S/C24H28N4O2/c1-14-6-7-21(26-10-14)18-9-17(18)13-30-23-20(12-25-16(3)28-23)19-11-27-22(8-15(19)2)24(4,5)29/h6-8,10-12,17-18,29H,9,13H2,1-5H3/t17-,18?/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329425
PNG
((4-(2-methyl-4- (((1S,2S)-2-(quinolin-2- yl)cyclop...)
Show SMILES Cc1ncc(-c2ccc(CO)cc2)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1
Show InChI InChI=1S/C25H23N3O2/c1-16-26-13-22(18-8-6-17(14-29)7-9-18)25(27-16)30-15-20-12-21(20)24-11-10-19-4-2-3-5-23(19)28-24/h2-11,13,20-21,29H,12,14-15H2,1H3/t20-,21+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329551
PNG
(1-(4-(4-(((1R,2R)-2-(6,7- dihydro-5H- cyclopenta[b...)
Show SMILES CC(O)c1nn(C)cc1-c1cnc(C)nc1OC[C@@H]1C[C@H]1c1ccc2CCCc2n1
Show InChI InChI=1S/C23H27N5O2/c1-13(29)22-19(11-28(3)27-22)18-10-24-14(2)25-23(18)30-12-16-9-17(16)21-8-7-15-5-4-6-20(15)26-21/h7-8,10-11,13,16-17,29H,4-6,9,12H2,1-3H3/t13?,16-,17+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329518
PNG
(2-((1S,2S)-2-((5-(5- methoxyimidazo[1,2- a]pyridin...)
Show SMILES COc1cc(cc2nccn12)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc2ccccc2n1
Show InChI InChI=1S/C26H23N5O2/c1-16-28-14-21(18-12-24-27-9-10-31(24)25(13-18)32-2)26(29-16)33-15-19-11-20(19)23-8-7-17-5-3-4-6-22(17)30-23/h3-10,12-14,19-20H,11,15H2,1-2H3/t19-,20+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329427
PNG
(5-(3-ethoxyphenyl)-2- methyl-6-(((1S,2S)-2- (quino...)
Show SMILES CCOc1cccc(c1)-c1cnc(C)[nH+]c1OC[C@H]1C[C@@H]1c1ccc2ccccc2n1
Show InChI InChI=1S/C26H25N3O2/c1-3-30-21-9-6-8-19(13-21)23-15-27-17(2)28-26(23)31-16-20-14-22(20)25-12-11-18-7-4-5-10-24(18)29-25/h4-13,15,20,22H,3,14,16H2,1-2H3/p+1/t20-,22+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329523
PNG
(2-((1S,2S)-2-((5- (imidazo[1,2-a]pyridin-6- yl)-2-...)
Show SMILES Cc1ncc(-c2ccc3nccn3c2)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1
Show InChI InChI=1S/C25H21N5O/c1-16-27-13-21(18-7-9-24-26-10-11-30(24)14-18)25(28-16)31-15-19-12-20(19)23-8-6-17-4-2-3-5-22(17)29-23/h2-11,13-14,19-20H,12,15H2,1H3/t19-,20+/m1/s1
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0.0400n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329567
PNG
(2-(5-(4-(((1S,2S)-2-(5- ethylpyridin-2- yl)cyclopr...)
Show SMILES CCc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccc(nc1)C(C)(C)O
Show InChI InChI=1S/C24H28N4O2/c1-5-16-6-8-21(26-11-16)19-10-18(19)14-30-23-20(13-25-15(2)28-23)17-7-9-22(27-12-17)24(3,4)29/h6-9,11-13,18-19,29H,5,10,14H2,1-4H3/t18-,19+/m1/s1
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0.0500n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329551
PNG
(1-(4-(4-(((1R,2R)-2-(6,7- dihydro-5H- cyclopenta[b...)
Show SMILES CC(O)c1nn(C)cc1-c1cnc(C)nc1OC[C@@H]1C[C@H]1c1ccc2CCCc2n1
Show InChI InChI=1S/C23H27N5O2/c1-13(29)22-19(11-28(3)27-22)18-10-24-14(2)25-23(18)30-12-16-9-17(16)21-8-7-15-5-4-6-20(15)26-21/h7-8,10-11,13,16-17,29H,4-6,9,12H2,1-3H3/t13?,16-,17+/m0/s1
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0.0500n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329419
PNG
(4-(2-methyl-4- (((1S,2S)-2-(quinolin-2- yl)cyclopr...)
Show SMILES Cc1ncc(-c2ccc(cc2)C#N)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1
Show InChI InChI=1S/C25H20N4O/c1-16-27-14-22(18-8-6-17(13-26)7-9-18)25(28-16)30-15-20-12-21(20)24-11-10-19-4-2-3-5-23(19)29-24/h2-11,14,20-21H,12,15H2,1H3/t20-,21+/m1/s1
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0.0600n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329433
PNG
(2-(5-(2-methyl-4-(((1S,2S)- 2-(5-methylpyridin-2- ...)
Show SMILES Cc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccc(nc1)C(C)(C)O
Show InChI InChI=1S/C23H26N4O2/c1-14-5-7-20(25-10-14)18-9-17(18)13-29-22-19(12-24-15(2)27-22)16-6-8-21(26-11-16)23(3,4)28/h5-8,10-12,17-18,28H,9,13H2,1-4H3/t17-,18+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329520
PNG
(2-((1S,2S)-2-((5- (imidazo[1,2-a]pyridin-3- yl)-2-...)
Show SMILES Cc1ncc(-c2cnc3ccccn23)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1
Show InChI InChI=1S/C25H21N5O/c1-16-26-13-20(23-14-27-24-8-4-5-11-30(23)24)25(28-16)31-15-18-12-19(18)22-10-9-17-6-2-3-7-21(17)29-22/h2-11,13-14,18-19H,12,15H2,1H3/t18-,19+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329578
PNG
(4-(2-methyl-4- (((1S,2S)-2-(quinolin-2- yl)cyclopr...)
Show SMILES Cc1ncc(C2CCC(=O)CC2)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1
Show InChI InChI=1S/C24H25N3O2/c1-15-25-13-21(16-6-9-19(28)10-7-16)24(26-15)29-14-18-12-20(18)23-11-8-17-4-2-3-5-22(17)27-23/h2-5,8,11,13,16,18,20H,6-7,9-10,12,14H2,1H3/t18-,20+/m1/s1
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0.0600n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329476
PNG
(1-(5-(4-(((1S,2S)-2-(5- methoxypyridin-2- yl)cyclo...)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccc(nc1)C1(O)CCCC1
Show InChI InChI=1S/C25H28N4O3/c1-16-26-14-21(17-5-8-23(28-12-17)25(30)9-3-4-10-25)24(29-16)32-15-18-11-20(18)22-7-6-19(31-2)13-27-22/h5-8,12-14,18,20,30H,3-4,9-11,15H2,1-2H3/t18-,20+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329577
PNG
(2-((1S,2S)-2-((2- methyl-5-(1,4- dioxaspiro[4.5]de...)
Show SMILES Cc1ncc(C2CCC3(CC2)OCCO3)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1
Show InChI InChI=1S/C26H29N3O3/c1-17-27-15-22(18-8-10-26(11-9-18)31-12-13-32-26)25(28-17)30-16-20-14-21(20)24-7-6-19-4-2-3-5-23(19)29-24/h2-7,15,18,20-21H,8-14,16H2,1H3/t20-,21+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329580
PNG
((1R,4s)-4-(2-methyl-4- (((1S,2R)-2-(quinolin-2- yl...)
Show SMILES Cc1ncc([C@@H]2CC[C@H](O)CC2)c(OC[C@H]2C[C@H]2c2ccc3ccccc3n2)n1
Show InChI InChI=1S/C24H27N3O2/c1-15-25-13-21(16-6-9-19(28)10-7-16)24(26-15)29-14-18-12-20(18)23-11-8-17-4-2-3-5-22(17)27-23/h2-5,8,11,13,16,18-20,28H,6-7,9-10,12,14H2,1H3/t16-,18-,19+,20-/m1/s1
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0.0700n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329430
PNG
(2-((1S,2S)-2-((2- methyl-5,5''- bipyrimidin-4- ylo...)
Show SMILES Cc1ncc(c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1)-c1cncnc1
Show InChI InChI=1S/C22H19N5O/c1-14-25-11-19(17-9-23-13-24-10-17)22(26-14)28-12-16-8-18(16)21-7-6-15-4-2-3-5-20(15)27-21/h2-7,9-11,13,16,18H,8,12H2,1H3/t16-,18+/m1/s1
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0.0800n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329423
PNG
(2-((1S,2S)-2-((2- methyl-5-m- tolylpyrimidin-4- yl...)
Show SMILES Cc1cccc(c1)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc2ccccc2n1
Show InChI InChI=1S/C25H23N3O/c1-16-6-5-8-19(12-16)22-14-26-17(2)27-25(22)29-15-20-13-21(20)24-11-10-18-7-3-4-9-23(18)28-24/h3-12,14,20-21H,13,15H2,1-2H3/t20-,21+/m1/s1
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0.0900n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329505
PNG
(2-(4-methyl-5-(2-methyl-4- (((1S,2S)-2-(pyridin-2-...)
Show SMILES Cc1ncc(c(OC[C@H]2C[C@@H]2c2ccccn2)n1)-c1cnc(cc1C)C(C)(C)O
Show InChI InChI=1S/C23H26N4O2/c1-14-9-21(23(3,4)28)26-11-18(14)19-12-25-15(2)27-22(19)29-13-16-10-17(16)20-7-5-6-8-24-20/h5-9,11-12,16-17,28H,10,13H2,1-4H3/t16-,17+/m1/s1
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0.100n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329454
PNG
(2,2-difluoro-1-(5-(4- (((1S,2S)-2-(5- methoxypyrid...)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccc(nc1)C(O)C(F)F
Show InChI InChI=1S/C22H22F2N4O3/c1-12-25-10-17(13-3-5-19(26-8-13)20(29)21(23)24)22(28-12)31-11-14-7-16(14)18-6-4-15(30-2)9-27-18/h3-6,8-10,14,16,20-21,29H,7,11H2,1-2H3/t14-,16+,20?/m1/s1
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0.100n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329609
PNG
(5-(4-(1H-tetrazol-5- yl)phenyl)-4-(((1S,2S)-2- (5-...)
Show SMILES COc1ccc(nc1)[C@H]1CC1COc1nc(C)ncc1-c1ccc(cc1)-c1nn[nH]n1
Show InChI InChI=1S/C22H21N7O2/c1-13-23-11-19(14-3-5-15(6-4-14)21-26-28-29-27-21)22(25-13)31-12-16-9-18(16)20-8-7-17(30-2)10-24-20/h3-8,10-11,16,18H,9,12H2,1-2H3,(H,26,27,28,29)/t16?,18-/m0/s1
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0.100n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329415
PNG
(2-((1S,2S)-2-((5-(4- methoxyphenyl)-2- methylpyrim...)
Show SMILES COc1ccc(cc1)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc2ccccc2n1
Show InChI InChI=1S/C25H23N3O2/c1-16-26-14-22(17-7-10-20(29-2)11-8-17)25(27-16)30-15-19-13-21(19)24-12-9-18-5-3-4-6-23(18)28-24/h3-12,14,19,21H,13,15H2,1-2H3/t19-,21+/m1/s1
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0.100n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329479
PNG
(1-(5-(4-(((1S,2S)-2-(5- methoxypyridin-2- yl)cyclo...)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccc(nc1)C1(O)CCC1
Show InChI InChI=1S/C24H26N4O3/c1-15-25-13-20(16-4-7-22(27-11-16)24(29)8-3-9-24)23(28-15)31-14-17-10-19(17)21-6-5-18(30-2)12-26-21/h4-7,11-13,17,19,29H,3,8-10,14H2,1-2H3/t17-,19+/m1/s1
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0.120n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329515
PNG
(2-((1S,2S)-2-((2-methyl-5- (4-methylpyridin-2- yl)...)
Show SMILES Cc1ccnc(c1)-c1cnc(C)nc1OC[C@H]1CC1c1ccc2ccccc2n1
Show InChI InChI=1S/C24H22N4O/c1-15-9-10-25-23(11-15)20-13-26-16(2)27-24(20)29-14-18-12-19(18)22-8-7-17-5-3-4-6-21(17)28-22/h3-11,13,18-19H,12,14H2,1-2H3/t18-,19?/m1/s1
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0.120n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329543
PNG
(2-((1S,2S)-2-((2-methyl- 5-(6- (trifluoromethyl)py...)
Show SMILES Cc1ncc(-c2ccc(nc2)C(F)(F)F)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1
Show InChI InChI=1S/C24H19F3N4O/c1-14-28-12-19(16-7-9-22(29-11-16)24(25,26)27)23(30-14)32-13-17-10-18(17)21-8-6-15-4-2-3-5-20(15)31-21/h2-9,11-12,17-18H,10,13H2,1H3/t17-,18+/m1/s1
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0.120n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329549
PNG
(1-(4-(4-(((1S,2S)-2-(5- ethylpyridin-2- yl)cyclopr...)
Show SMILES CCc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1cn(C)nc1C(C)O
Show InChI InChI=1S/C22H27N5O2/c1-5-15-6-7-20(24-9-15)17-8-16(17)12-29-22-18(10-23-14(3)25-22)19-11-27(4)26-21(19)13(2)28/h6-7,9-11,13,16-17,28H,5,8,12H2,1-4H3/t13?,16-,17+/m1/s1
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0.130n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329616
PNG
(5-(6-(2H-tetrazol-5- yl)pyridin-3-yl)-4- (((1S,2S)...)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccc(nc1)-c1nn[nH]n1
Show InChI InChI=1S/C21H20N8O2/c1-12-22-10-17(13-3-5-19(23-8-13)20-26-28-29-27-20)21(25-12)31-11-14-7-16(14)18-6-4-15(30-2)9-24-18/h3-6,8-10,14,16H,7,11H2,1-2H3,(H,26,27,28,29)/t14-,16+/m1/s1
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0.130n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329462
PNG
(5-(2-ethoxypyridin-4-yl)- 4-(((1S,2S)-2-(5- methox...)
Show SMILES CCOc1cc(ccn1)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(OC)cn1
Show InChI InChI=1S/C22H24N4O3/c1-4-28-21-10-15(7-8-23-21)19-12-24-14(2)26-22(19)29-13-16-9-18(16)20-6-5-17(27-3)11-25-20/h5-8,10-12,16,18H,4,9,13H2,1-3H3/t16-,18+/m1/s1
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0.140n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329528
PNG
(1-(5-(2-methyl-4- (((1S,2S)-2-(5- methylpyridin-2-...)
Show SMILES CC(O)c1ccc(cn1)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(C)cn1
Show InChI InChI=1S/C22H24N4O2/c1-13-4-6-21(24-9-13)18-8-17(18)12-28-22-19(11-23-15(3)26-22)16-5-7-20(14(2)27)25-10-16/h4-7,9-11,14,17-18,27H,8,12H2,1-3H3/t14?,17-,18+/m1/s1
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0.140n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329470
PNG
(2,2,2-trifluoro-1-(5-(4- (((1S,2S)-2-(5- methoxypy...)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccc(nc1)C(O)C(F)(F)F
Show InChI InChI=1S/C22H21F3N4O3/c1-12-26-10-17(13-3-5-19(27-8-13)20(30)22(23,24)25)21(29-12)32-11-14-7-16(14)18-6-4-15(31-2)9-28-18/h3-6,8-10,14,16,20,30H,7,11H2,1-2H3/t14-,16+,20?/m1/s1
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0.150n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329480
PNG
(5-(4-(4-(((1S,2S)-2-(5- methoxypyridin-2- yl)cyclo...)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccc(cc1)-c1ncno1
Show InChI InChI=1S/C23H21N5O3/c1-14-24-11-20(15-3-5-16(6-4-15)22-26-13-27-31-22)23(28-14)30-12-17-9-19(17)21-8-7-18(29-2)10-25-21/h3-8,10-11,13,17,19H,9,12H2,1-2H3/t17-,19+/m1/s1
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0.150n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329530
PNG
(1-(5-(2-methyl-4- (((1S,2S)-2-(5- methylpyridin-2-...)
Show SMILES CCC(O)c1ccc(cn1)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(C)cn1
Show InChI InChI=1S/C23H26N4O2/c1-4-22(28)21-8-6-16(11-26-21)19-12-24-15(3)27-23(19)29-13-17-9-18(17)20-7-5-14(2)10-25-20/h5-8,10-12,17-18,22,28H,4,9,13H2,1-3H3/t17-,18+,22?/m1/s1
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0.160n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329478
PNG
(3-(5-(4-(((1S,2S)-2-(5- methoxypyridin-2- yl)cyclo...)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccc(nc1)C1(O)COC1
Show InChI InChI=1S/C23H24N4O4/c1-14-24-10-19(15-3-6-21(26-8-15)23(28)12-30-13-23)22(27-14)31-11-16-7-18(16)20-5-4-17(29-2)9-25-20/h3-6,8-10,16,18,28H,7,11-13H2,1-2H3/t16-,18+/m1/s1
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0.160n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329461
PNG
(5-(2-isopropoxypyridin-4- yl)-4-(((1S,2S)-2-(5- me...)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccnc(OC(C)C)c1
Show InChI InChI=1S/C23H26N4O3/c1-14(2)30-22-10-16(7-8-24-22)20-12-25-15(3)27-23(20)29-13-17-9-19(17)21-6-5-18(28-4)11-26-21/h5-8,10-12,14,17,19H,9,13H2,1-4H3/t17-,19+/m1/s1
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US Patent
0.180n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329469
PNG
(4-(((1S,2S)-2-(5- methoxypyridin-2- yl)cyclopropyl...)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1cn(C)nc1C(F)(F)F
Show InChI InChI=1S/C20H20F3N5O2/c1-11-24-8-15(16-9-28(2)27-18(16)20(21,22)23)19(26-11)30-10-12-6-14(12)17-5-4-13(29-3)7-25-17/h4-5,7-9,12,14H,6,10H2,1-3H3/t12-,14+/m1/s1
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0.200n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329562
PNG
(2-(5-(2-methyl-4- (((1S,2S)-2-(6- methylpyridin-2-...)
Show SMILES Cc1cccc(n1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccc(nc1)C(C)(C)O
Show InChI InChI=1S/C23H26N4O2/c1-14-6-5-7-20(26-14)18-10-17(18)13-29-22-19(12-24-15(2)27-22)16-8-9-21(25-11-16)23(3,4)28/h5-9,11-12,17-18,28H,10,13H2,1-4H3/t17-,18+/m1/s1
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0.200n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329525
PNG
(2-(6-Methyl-5-(2-methyl- 4-(((1S,2S)-2-(5- methylp...)
Show SMILES Cc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccc(nc1C)C(C)(C)O
Show InChI InChI=1S/C24H28N4O2/c1-14-6-8-21(26-11-14)19-10-17(19)13-30-23-20(12-25-16(3)28-23)18-7-9-22(24(4,5)29)27-15(18)2/h6-9,11-12,17,19,29H,10,13H2,1-5H3/t17-,19+/m1/s1
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0.230n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329528
PNG
(1-(5-(2-methyl-4- (((1S,2S)-2-(5- methylpyridin-2-...)
Show SMILES CC(O)c1ccc(cn1)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(C)cn1
Show InChI InChI=1S/C22H24N4O2/c1-13-4-6-21(24-9-13)18-8-17(18)12-28-22-19(11-23-15(3)26-22)16-5-7-20(14(2)27)25-10-16/h4-7,9-11,14,17-18,27H,8,12H2,1-3H3/t14?,17-,18+/m1/s1
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0.240n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329549
PNG
(1-(4-(4-(((1S,2S)-2-(5- ethylpyridin-2- yl)cyclopr...)
Show SMILES CCc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1cn(C)nc1C(C)O
Show InChI InChI=1S/C22H27N5O2/c1-5-15-6-7-20(24-9-15)17-8-16(17)12-29-22-18(10-23-14(3)25-22)19-11-27(4)26-21(19)13(2)28/h6-7,9-11,13,16-17,28H,5,8,12H2,1-4H3/t13?,16-,17+/m1/s1
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0.240n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%