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Patent code US9663513

Compile Data Set for Download or QSAR

Found 257 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329532
PNG
(2,2,2-trifluoro-1-(5-(2- methyl-4-(((1S,2S)-2-(5- ...)
Show SMILES Cc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccc(nc1)C(O)C(F)(F)F
Show InChI InChI=1S/C22H21F3N4O2/c1-12-3-5-18(27-8-12)16-7-15(16)11-31-21-17(10-26-13(2)29-21)14-4-6-19(28-9-14)20(30)22(23,24)25/h3-6,8-10,15-16,20,30H,7,11H2,1-2H3/t15-,16+,20?/m1/s1
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US Patent
0.25n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329559
PNG
(4-(4-(((1S,2S)-2-(5- methoxypyridin-2- yl)cyclopro...)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H21N3O4/c1-13-23-11-19(14-3-5-15(6-4-14)22(26)27)21(25-13)29-12-16-9-18(16)20-8-7-17(28-2)10-24-20/h3-8,10-11,16,18H,9,12H2,1-2H3,(H,26,27)/t16-,18+/m1/s1
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0.290n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329390
PNG
(5-(3- isopropoxyphenyl)-2- methyl-4-(((1S,2S)-2- (...)
Show SMILES CC(C)Oc1cccc(c1)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(C)cn1
Show InChI InChI=1S/C24H27N3O2/c1-15(2)29-20-7-5-6-18(10-20)22-13-25-17(4)27-24(22)28-14-19-11-21(19)23-9-8-16(3)12-26-23/h5-10,12-13,15,19,21H,11,14H2,1-4H3/t19-,21+/m1/s1
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0.300n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329408
PNG
(5-(2-fluoropyridin-4- yl)-4-(((1S,2S)-2-(5- methox...)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccnc(F)c1
Show InChI InChI=1S/C20H19FN4O2/c1-12-23-10-17(13-5-6-22-19(21)8-13)20(25-12)27-11-14-7-16(14)18-4-3-15(26-2)9-24-18/h3-6,8-10,14,16H,7,11H2,1-2H3/t14-,16+/m1/s1
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0.330n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329411
PNG
(2-((1S,2S)-2-((2- methyl-5-p-tolylpyrimidin- 4-ylo...)
Show SMILES Cc1ccc(cc1)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc2ccccc2n1
Show InChI InChI=1S/C25H23N3O/c1-16-7-9-18(10-8-16)22-14-26-17(2)27-25(22)29-15-20-13-21(20)24-12-11-19-5-3-4-6-23(19)28-24/h3-12,14,20-21H,13,15H2,1-2H3/t20-,21+/m1/s1
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0.350n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329417
PNG
(2-((1S,2S)-2-((5-(4- ethylphenyl)-2- methylpyrimid...)
Show SMILES CCc1ccc(cc1)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc2ccccc2n1
Show InChI InChI=1S/C26H25N3O/c1-3-18-8-10-19(11-9-18)23-15-27-17(2)28-26(23)30-16-21-14-22(21)25-13-12-20-6-4-5-7-24(20)29-25/h4-13,15,21-22H,3,14,16H2,1-2H3/t21-,22+/m1/s1
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0.370n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329529
PNG
(5-(2-methyl-4-(((1S,2S)- 2-(5-methylpyridin-2- yl)...)
Show SMILES Cc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1cnc2[nH]ncc2c1
Show InChI InChI=1S/C21H20N6O/c1-12-3-4-19(23-7-12)17-6-16(17)11-28-21-18(10-22-13(2)26-21)14-5-15-9-25-27-20(15)24-8-14/h3-5,7-10,16-17H,6,11H2,1-2H3,(H,24,25,27)/t16-,17+/m1/s1
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0.370n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329526
PNG
(2-methyl-1-(5-(2-methyl- 4-(((1S,2S)-2-(5- methylp...)
Show SMILES CC(C)C(O)c1ccc(cn1)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(C)cn1
Show InChI InChI=1S/C24H28N4O2/c1-14(2)23(29)22-8-6-17(11-27-22)20-12-25-16(4)28-24(20)30-13-18-9-19(18)21-7-5-15(3)10-26-21/h5-8,10-12,14,18-19,23,29H,9,13H2,1-4H3/t18-,19+,23?/m1/s1
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0.370n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329564
PNG
(2-(5-(2-methyl-4- (((1S,2S)-2-(4- methylpyridin-2-...)
Show SMILES Cc1ccnc(c1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccc(nc1)C(C)(C)O
Show InChI InChI=1S/C23H26N4O2/c1-14-7-8-24-20(9-14)18-10-17(18)13-29-22-19(12-25-15(2)27-22)16-5-6-21(26-11-16)23(3,4)28/h5-9,11-12,17-18,28H,10,13H2,1-4H3/t17-,18+/m1/s1
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0.380n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329517
PNG
(3-methyl-6-(2-methyl-4- (((1S,2S)-2-(5- methylpyri...)
Show SMILES Cc1cnc2ccc(cn12)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(C)cn1
Show InChI InChI=1S/C23H23N5O/c1-14-4-6-21(25-9-14)19-8-18(19)13-29-23-20(11-24-16(3)27-23)17-5-7-22-26-10-15(2)28(22)12-17/h4-7,9-12,18-19H,8,13H2,1-3H3/t18-,19+/m1/s1
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0.390n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329512
PNG
(5-(3-(difluoromethyl)-1- methyl-1H-pyrazol-4-yl)-2...)
Show SMILES Cc1ccc(nc1)C1C[C@@H]1COc1nc(C)ncc1-c1cn(C)nc1C(F)F
Show InChI InChI=1S/C20H21F2N5O/c1-11-4-5-17(24-7-11)14-6-13(14)10-28-20-15(8-23-12(2)25-20)16-9-27(3)26-18(16)19(21)22/h4-5,7-9,13-14,19H,6,10H2,1-3H3/t13-,14?/m1/s1
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0.400n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329534
PNG
(2-methyl-4-(((1S,2S)-2- (5-methylpyridin-2- yl)cyc...)
Show SMILES Cc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccncc1C
Show InChI InChI=1S/C21H22N4O/c1-13-4-5-20(24-9-13)18-8-16(18)12-26-21-19(11-23-15(3)25-21)17-6-7-22-10-14(17)2/h4-7,9-11,16,18H,8,12H2,1-3H3/t16-,18+/m1/s1
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0.400n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329454
PNG
(2,2-difluoro-1-(5-(4- (((1S,2S)-2-(5- methoxypyrid...)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccc(nc1)C(O)C(F)F
Show InChI InChI=1S/C22H22F2N4O3/c1-12-25-10-17(13-3-5-19(26-8-13)20(29)21(23)24)22(28-12)31-11-14-7-16(14)18-6-4-15(30-2)9-27-18/h3-6,8-10,14,16,20-21,29H,7,11H2,1-2H3/t14-,16+,20?/m1/s1
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0.430n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329474
PNG
(5-(2-chloro-5- (trifluoromethyl)pyridin-3- yl)-4-(...)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1cc(cnc1Cl)C(F)(F)F
Show InChI InChI=1S/C21H18ClF3N4O2/c1-11-26-9-17(16-6-13(21(23,24)25)7-28-19(16)22)20(29-11)31-10-12-5-15(12)18-4-3-14(30-2)8-27-18/h3-4,6-9,12,15H,5,10H2,1-2H3/t12-,15+/m1/s1
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0.440n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329394
PNG
(5-(3,5-difluorophenyl)- 2-methyl-4-(((1S,2S)-2- (5...)
Show SMILES Cc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1cc(F)cc(F)c1
Show InChI InChI=1S/C21H19F2N3O/c1-12-3-4-20(25-9-12)18-7-15(18)11-27-21-19(10-24-13(2)26-21)14-5-16(22)8-17(23)6-14/h3-6,8-10,15,18H,7,11H2,1-2H3/t15-,18+/m1/s1
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0.460n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329537
PNG
(5-(3-methoxypyridin-4- yl)-2-methyl-4-(((1S,2S)- 2...)
Show SMILES COc1cnccc1-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(C)cn1
Show InChI InChI=1S/C21H22N4O2/c1-13-4-5-19(24-9-13)17-8-15(17)12-27-21-18(10-23-14(2)25-21)16-6-7-22-11-20(16)26-3/h4-7,9-11,15,17H,8,12H2,1-3H3/t15-,17+/m1/s1
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0.470n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329594
PNG
(3-(4-(((1S,2S)-2-(5- Methoxypyridin-2- yl)cyclopro...)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1C1CCCC(=O)C1
Show InChI InChI=1S/C21H25N3O3/c1-13-22-11-19(14-4-3-5-16(25)8-14)21(24-13)27-12-15-9-18(15)20-7-6-17(26-2)10-23-20/h6-7,10-11,14-15,18H,3-5,8-9,12H2,1-2H3/t14?,15-,18+/m1/s1
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0.480n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329463
PNG
(3-(4-(((1S,2S)-2-(5- methoxypyridin-2- yl)cyclopro...)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1C1=CC(=O)CC1
Show InChI InChI=1S/C20H21N3O3/c1-12-21-10-18(13-3-4-15(24)7-13)20(23-12)26-11-14-8-17(14)19-6-5-16(25-2)9-22-19/h5-7,9-10,14,17H,3-4,8,11H2,1-2H3/t14-,17+/m1/s1
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0.480n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329605
PNG
(US9663513, 218 | cis-4-(4-(((1S,2S)-2- (5-Methoxyp...)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1C1CC[C@@H](CC1)C(N)=O
Show InChI InChI=1S/C22H28N4O3/c1-13-24-11-19(14-3-5-15(6-4-14)21(23)27)22(26-13)29-12-16-9-18(16)20-8-7-17(28-2)10-25-20/h7-8,10-11,14-16,18H,3-6,9,12H2,1-2H3,(H2,23,27)/t14?,15-,16-,18+/m1/s1
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0.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329583
PNG
(Trans-4-(4-(((1S,2R)-2- (5-ethylpyridin-2- yl)cycl...)
Show SMILES CCc1ccc(nc1)[C@@H]1C[C@@H]1COc1nc(C)ncc1[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C22H29N3O2/c1-3-15-4-9-21(24-11-15)19-10-17(19)13-27-22-20(12-23-14(2)25-22)16-5-7-18(26)8-6-16/h4,9,11-12,16-19,26H,3,5-8,10,13H2,1-2H3/t16-,17-,18-,19-/m1/s1
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0.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329459
PNG
(5-(6- (cyclopropylmethoxy) pyridin-3-yl)-4-(((1S,2...)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccc(OCC2CC2)nc1
Show InChI InChI=1S/C24H26N4O3/c1-15-25-12-21(17-5-8-23(27-10-17)30-13-16-3-4-16)24(28-15)31-14-18-9-20(18)22-7-6-19(29-2)11-26-22/h5-8,10-12,16,18,20H,3-4,9,13-14H2,1-2H3/t18-,20+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329470
PNG
(2,2,2-trifluoro-1-(5-(4- (((1S,2S)-2-(5- methoxypy...)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccc(nc1)C(O)C(F)(F)F
Show InChI InChI=1S/C22H21F3N4O3/c1-12-26-10-17(13-3-5-19(27-8-13)20(30)22(23,24)25)21(29-12)32-11-14-7-16(14)18-6-4-15(31-2)9-28-18/h3-6,8-10,14,16,20,30H,7,11H2,1-2H3/t14-,16+,20?/m1/s1
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0.510n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329514
PNG
(2-((1S,2S)-2-((5-(3- fluoropyridin-2-yl)-2- methyl...)
Show SMILES Cc1ncc(c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1)-c1ncccc1F
Show InChI InChI=1S/C23H19FN4O/c1-14-26-12-18(22-19(24)6-4-10-25-22)23(27-14)29-13-16-11-17(16)21-9-8-15-5-2-3-7-20(15)28-21/h2-10,12,16-17H,11,13H2,1H3/t16-,17+/m1/s1
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0.510n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329560
PNG
(2-(5-(2-methyl-4- (((1S,2S)-2-(3- methylpyridin-2-...)
Show SMILES Cc1ncc(-c2ccc(nc2)C(C)(C)O)c(OC[C@H]2C[C@@H]2c2ncccc2C)n1
Show InChI InChI=1S/C23H26N4O2/c1-14-6-5-9-24-21(14)18-10-17(18)13-29-22-19(12-25-15(2)27-22)16-7-8-20(26-11-16)23(3,4)28/h5-9,11-12,17-18,28H,10,13H2,1-4H3/t17-,18+/m1/s1
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0.510n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329532
PNG
(2,2,2-trifluoro-1-(5-(2- methyl-4-(((1S,2S)-2-(5- ...)
Show SMILES Cc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccc(nc1)C(O)C(F)(F)F
Show InChI InChI=1S/C22H21F3N4O2/c1-12-3-5-18(27-8-12)16-7-15(16)11-31-21-17(10-26-13(2)29-21)14-4-6-19(28-9-14)20(30)22(23,24)25/h3-6,8-10,15-16,20,30H,7,11H2,1-2H3/t15-,16+,20?/m1/s1
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0.540n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329406
PNG
(5-(2-fluoropyridin-4- yl)-2-methyl-4- (((1S,2S)-2-...)
Show SMILES Cc1ccc(nc1)C1C[C@@H]1COc1nc(C)ncc1-c1ccnc(F)c1
Show InChI InChI=1S/C20H19FN4O/c1-12-3-4-18(24-9-12)16-7-15(16)11-26-20-17(10-23-13(2)25-20)14-5-6-22-19(21)8-14/h3-6,8-10,15-16H,7,11H2,1-2H3/t15-,16?/m1/s1
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0.550n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329545
PNG
(1-(1-methyl-4-(2-methyl- 4-(((1S,2S)-2-(6- methylp...)
Show SMILES CC(O)c1nn(C)cc1-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1cccc(C)n1
Show InChI InChI=1S/C21H25N5O2/c1-12-6-5-7-19(23-12)16-8-15(16)11-28-21-17(9-22-14(3)24-21)18-10-26(4)25-20(18)13(2)27/h5-7,9-10,13,15-16,27H,8,11H2,1-4H3/t13?,15-,16+/m1/s1
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0.560n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329444
PNG
(5-(6-(2- methoxyethoxy)pyridin-3- yl)-2-methyl-4-(...)
Show SMILES COCCOc1ccc(cn1)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(C)cn1
Show InChI InChI=1S/C23H26N4O3/c1-15-4-6-21(25-11-15)19-10-18(19)14-30-23-20(13-24-16(2)27-23)17-5-7-22(26-12-17)29-9-8-28-3/h4-7,11-13,18-19H,8-10,14H2,1-3H3/t18-,19+/m1/s1
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0.570n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329566
PNG
(2-(5-(4-(((1S,2S)-2-(5- fluoropyridin-2- yl)cyclop...)
Show SMILES Cc1ncc(c(OC[C@H]2C[C@@H]2c2ccc(F)cn2)n1)-c1ccc(nc1)C(C)(C)O
Show InChI InChI=1S/C22H23FN4O2/c1-13-24-11-18(14-4-7-20(26-9-14)22(2,3)28)21(27-13)29-12-15-8-17(15)19-6-5-16(23)10-25-19/h4-7,9-11,15,17,28H,8,12H2,1-3H3/t15-,17+/m1/s1
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0.570n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329404
PNG
(2-methyl-4-(((1S,2S)-2- (5-methylpyridin-2- yl)cyc...)
Show SMILES Cc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccncc1C(F)(F)F
Show InChI InChI=1S/C21H19F3N4O/c1-12-3-4-19(27-8-12)16-7-14(16)11-29-20-17(9-26-13(2)28-20)15-5-6-25-10-18(15)21(22,23)24/h3-6,8-10,14,16H,7,11H2,1-2H3/t14-,16+/m1/s1
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0.590n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329524
PNG
(6-(2-methyl-4-(((1S,2S)-2- (5-methylpyridin-2- yl)...)
Show SMILES Cc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccc2nccn2c1
Show InChI InChI=1S/C22H21N5O/c1-14-3-5-20(25-10-14)18-9-17(18)13-28-22-19(11-24-15(2)26-22)16-4-6-21-23-7-8-27(21)12-16/h3-8,10-12,17-18H,9,13H2,1-2H3/t17-,18+/m1/s1
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0.630n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329493
PNG
(N-(2-hydroxyethyl)-5-(4- (((1S,2S)-2-(5- methoxypy...)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccc(nc1)C(=O)NCCO
Show InChI InChI=1S/C23H25N5O4/c1-14-25-12-19(15-3-5-21(26-10-15)22(30)24-7-8-29)23(28-14)32-13-16-9-18(16)20-6-4-17(31-2)11-27-20/h3-6,10-12,16,18,29H,7-9,13H2,1-2H3,(H,24,30)/t16-,18+/m1/s1
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0.640n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329607
PNG
((trans) 2-(4-4- (((1S,2S)-2-5- methoxypyridin-2- y...)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1[C@H]1CCC(CC1)C(C)(C)O
Show InChI InChI=1S/C24H33N3O3/c1-15-25-13-21(16-5-7-18(8-6-16)24(2,3)28)23(27-15)30-14-17-11-20(17)22-10-9-19(29-4)12-26-22/h9-10,12-13,16-18,20,28H,5-8,11,14H2,1-4H3/t16-,17-,18?,20+/m1/s1
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0.640n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329606
PNG
(US9663513, 219 | trans-4-(4-(((1S,2S)-2- (5-Methox...)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1C1CC[C@@H](CC1)C(N)=O
Show InChI InChI=1S/C22H28N4O3/c1-13-24-11-19(14-3-5-15(6-4-14)21(23)27)22(26-13)29-12-16-9-18(16)20-8-7-17(28-2)10-25-20/h7-8,10-11,14-16,18H,3-6,9,12H2,1-2H3,(H2,23,27)/t14?,15-,16-,18+/m1/s1
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0.650n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329491
PNG
(5-(4-(((1S,2S)-2-(5- methoxypyridin-2- yl)cyclopro...)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccc(nc1)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C23H22F3N5O3/c1-13-27-10-18(14-3-5-20(28-8-14)21(32)30-12-23(24,25)26)22(31-13)34-11-15-7-17(15)19-6-4-16(33-2)9-29-19/h3-6,8-10,15,17H,7,11-12H2,1-2H3,(H,30,32)/t15-,17+/m1/s1
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0.670n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329400
PNG
(5-(2,5-dimethylphenyl)- 2-methyl-4-(((1S,2S)-2- (5...)
Show SMILES Cc1ccc(nc1)C1C[C@@H]1COc1nc(C)ncc1-c1cc(C)ccc1C
Show InChI InChI=1S/C23H25N3O/c1-14-5-7-16(3)19(9-14)21-12-24-17(4)26-23(21)27-13-18-10-20(18)22-8-6-15(2)11-25-22/h5-9,11-12,18,20H,10,13H2,1-4H3/t18-,20?/m1/s1
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0.700n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329631
PNG
(4-(4-(((1S,2S)-2-(5- methoxypyridin-2- yl)cyclopro...)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1cn(C)[nH]c1=O
Show InChI InChI=1S/C19H21N5O3/c1-11-20-8-15(16-9-24(2)23-18(16)25)19(22-11)27-10-12-6-14(12)17-5-4-13(26-3)7-21-17/h4-5,7-9,12,14H,6,10H2,1-3H3,(H,23,25)/t12-,14+/m1/s1
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0.710n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329591
PNG
(Step A: 2-((2S)-2-methyl-3-(2-methyl-5-(1,4-dioxas...)
Show SMILES C[C@H](COc1nc(C)ncc1C1CCC2(CC1)OCCO2)Cc1ccc2ccccc2n1
Show InChI InChI=1S/C26H31N3O3/c1-18(15-22-8-7-21-5-3-4-6-24(21)29-22)17-30-25-23(16-27-19(2)28-25)20-9-11-26(12-10-20)31-13-14-32-26/h3-8,16,18,20H,9-15,17H2,1-2H3/t18-/m0/s1
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0.730n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329530
PNG
(1-(5-(2-methyl-4- (((1S,2S)-2-(5- methylpyridin-2-...)
Show SMILES CCC(O)c1ccc(cn1)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(C)cn1
Show InChI InChI=1S/C23H26N4O2/c1-4-22(28)21-8-6-16(11-26-21)19-12-24-15(3)27-23(19)29-13-17-9-18(17)20-7-5-14(2)10-25-20/h5-8,10-12,17-18,22,28H,4,9,13H2,1-3H3/t17-,18+,22?/m1/s1
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0.730n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329403
PNG
(5-(2-methoxypyridin-3- yl)-2-methyl-4- (((1S,2S)-2...)
Show SMILES COc1ncccc1-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(C)cn1
Show InChI InChI=1S/C21H22N4O2/c1-13-6-7-19(24-10-13)17-9-15(17)12-27-21-18(11-23-14(2)25-21)16-5-4-8-22-20(16)26-3/h4-8,10-11,15,17H,9,12H2,1-3H3/t15-,17+/m1/s1
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0.740n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329502
PNG
(5-(3,6-dihydro-2H-pyran- 4-yl)-4-(((1S,2S)-2-(5- ...)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1C1=CCOCC1
Show InChI InChI=1S/C20H23N3O3/c1-13-21-11-18(14-5-7-25-8-6-14)20(23-13)26-12-15-9-17(15)19-4-3-16(24-2)10-22-19/h3-5,10-11,15,17H,6-9,12H2,1-2H3/t15-,17+/m1/s1
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0.760n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329619
PNG
(5-(6-(2-ethyl-2H-tetrazol- 5-yl)pyridin-3-yl)-4- (...)
Show SMILES CCn1nnc(n1)-c1ccc(cn1)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(OC)cn1
Show InChI InChI=1S/C23H24N8O2/c1-4-31-29-22(28-30-31)21-7-5-15(10-25-21)19-12-24-14(2)27-23(19)33-13-16-9-18(16)20-8-6-17(32-3)11-26-20/h5-8,10-12,16,18H,4,9,13H2,1-3H3/t16-,18+/m1/s1
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0.770n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329613
PNG
(5-(4-(1-ethyl-1H-tetrazol- 5-yl)phenyl)-4-(((1S,2S...)
Show SMILES CCn1nnnc1-c1ccc(cc1)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(OC)cn1
Show InChI InChI=1S/C24H25N7O2/c1-4-31-23(28-29-30-31)17-7-5-16(6-8-17)21-13-25-15(2)27-24(21)33-14-18-11-20(18)22-10-9-19(32-3)12-26-22/h5-10,12-13,18,20H,4,11,14H2,1-3H3/t18-,20+/m1/s1
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0.770n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329498
PNG
(5-(2-chloro-5- methoxypyridin-4-yl)-4- (((1S,2S)-2...)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1cc(Cl)ncc1OC
Show InChI InChI=1S/C21H21ClN4O3/c1-12-23-9-17(16-7-20(22)25-10-19(16)28-3)21(26-12)29-11-13-6-15(13)18-5-4-14(27-2)8-24-18/h4-5,7-10,13,15H,6,11H2,1-3H3/t13-,15+/m1/s1
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0.790n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329519
PNG
(5-methoxy-7-(2-methyl-4- (((1S,2S)-2-(5- methylpyr...)
Show SMILES COc1cc(cc2nccn12)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(C)cn1
Show InChI InChI=1S/C23H23N5O2/c1-14-4-5-20(26-11-14)18-8-17(18)13-30-23-19(12-25-15(2)27-23)16-9-21-24-6-7-28(21)22(10-16)29-3/h4-7,9-12,17-18H,8,13H2,1-3H3/t17-,18+/m1/s1
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0.810n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329367
PNG
(2-Methyl-4-(((1S,2S)-2- (5-methylpyridin-2- yl)cyc...)
Show SMILES Cc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H20F3N3O/c1-13-6-7-20(27-10-13)18-9-16(18)12-29-21-19(11-26-14(2)28-21)15-4-3-5-17(8-15)22(23,24)25/h3-8,10-11,16,18H,9,12H2,1-2H3/t16-,18+/m1/s1
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0.830n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329472
PNG
(5-(6-ethylpyridin-3-yl)-4- (((1S,2S)-2-(5- methoxy...)
Show SMILES CCc1ccc(cn1)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(OC)cn1
Show InChI InChI=1S/C22H24N4O2/c1-4-17-6-5-15(10-24-17)20-12-23-14(2)26-22(20)28-13-16-9-19(16)21-8-7-18(27-3)11-25-21/h5-8,10-12,16,19H,4,9,13H2,1-3H3/t16-,19+/m1/s1
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0.860n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329425
PNG
((4-(2-methyl-4- (((1S,2S)-2-(quinolin-2- yl)cyclop...)
Show SMILES Cc1ncc(-c2ccc(CO)cc2)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1
Show InChI InChI=1S/C25H23N3O2/c1-16-26-13-22(18-8-6-17(14-29)7-9-18)25(27-16)30-15-20-12-21(20)24-11-10-19-4-2-3-5-23(19)28-24/h2-11,13,20-21,29H,12,14-15H2,1H3/t20-,21+/m1/s1
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0.870n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329442
PNG
(5-(4,6-dimethylpyridin-3- yl)-2-methyl-4-(((1S,2S)...)
Show SMILES Cc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1cnc(C)cc1C
Show InChI InChI=1S/C22H24N4O/c1-13-5-6-21(25-9-13)18-8-17(18)12-27-22-20(11-24-16(4)26-22)19-10-23-15(3)7-14(19)2/h5-7,9-11,17-18H,8,12H2,1-4H3/t17-,18+/m1/s1
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0.870n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329500
PNG
(4-(4-(((1S,2S)-2-(5- methoxypyridin-2- yl)cyclop...)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1cc(C#N)n(C)c1
Show InChI InChI=1S/C21H21N5O2/c1-13-23-10-19(14-6-16(8-22)26(2)11-14)21(25-13)28-12-15-7-18(15)20-5-4-17(27-3)9-24-20/h4-6,9-11,15,18H,7,12H2,1-3H3/t15-,18+/m1/s1
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0.890n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%