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Patent code US9663528

Compile Data Set for Download or QSAR
Found 23 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Solute carrier family 22 member 2


(Homo sapiens (Human))		BDBM330053
PNG
((2R,5S,13aR)-N-(2-chloro-4-fluorobenzyl)-8-hydroxy...)
Show SMILES Oc1c2C(=O)N3[C@H]4CC[C@H](C4)[C@H]3Cn2cc(C(=O)NCc2ccc(Cl)cc2F)c1=O
Show InChI InChI=1S/C21H19ClFN3O4/c22-12-3-1-11(15(23)6-12)7-24-20(29)14-8-25-9-16-10-2-4-13(5-10)26(16)21(30)17(25)19(28)18(14)27/h1,3,6,8,10,13,16,28H,2,4-5,7,9H2,(H,24,29)/t10-,13+,16-/m1/s1
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n/an/a 42n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...

US Patent US9663528 (2017)


BindingDB Entry DOI: 10.7270/Q24F1SVF
More data for this
Ligand-Target Pair
Solute carrier family 22 member 2


(Homo sapiens (Human))		BDBM330054
PNG
((2R,5S,13aR)-8-hydroxy-7,9-dioxo-N-(2,4,5-trifluor...)
Show SMILES Oc1c2C(=O)N3[C@H]4CC[C@H](C4)O[C@@H]3Cn2cc(C(=O)NCc2cc(F)c(F)cc2F)c1=O
Show InChI InChI=1S/C21H18F3N3O5/c22-13-5-15(24)14(23)3-9(13)6-25-20(30)12-7-26-8-16-27(10-1-2-11(4-10)32-16)21(31)17(26)19(29)18(12)28/h3,5,7,10-11,16,29H,1-2,4,6,8H2,(H,25,30)/t10-,11+,16+/m0/s1
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Gilead Sciences Inc

US Patent


Assay Description
The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...

US Patent US9663528 (2017)


BindingDB Entry DOI: 10.7270/Q24F1SVF
More data for this
Ligand-Target Pair
Solute carrier family 22 member 2


(Homo sapiens (Human))		BDBM330049
PNG
((13aS)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzy...)
Show SMILES Oc1c2C(=O)N3C4CCC(C4)O[C@H]3Cn2cc(C(=O)NCc2c(F)cc(F)cc2F)c1=O
Show InChI InChI=1S/C21H18F3N3O5/c22-9-3-14(23)12(15(24)4-9)6-25-20(30)13-7-26-8-16-27(10-1-2-11(5-10)32-16)21(31)17(26)19(29)18(13)28/h3-4,7,10-11,16,29H,1-2,5-6,8H2,(H,25,30)/t10?,11?,16-/m0/s1
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n/an/a 137n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...

US Patent US9663528 (2017)


BindingDB Entry DOI: 10.7270/Q24F1SVF
More data for this
Ligand-Target Pair
Solute carrier family 22 member 2


(Homo sapiens (Human))		BDBM330045
PNG
((2R,3S,5R,3aS)-N-(2,4-difluorobenzyl)-8-hydroxy-3-...)
Show SMILES CC1C[C@@H]2C[C@H]1OC1Cn3cc(C(=O)NCc4ccc(F)cc4F)c(=O)c(O)c3C(=O)N21
Show InChI InChI=1S/C22H21F2N3O5/c1-10-4-13-6-16(10)32-17-9-26-8-14(19(28)20(29)18(26)22(31)27(13)17)21(30)25-7-11-2-3-12(23)5-15(11)24/h2-3,5,8,10,13,16-17,29H,4,6-7,9H2,1H3,(H,25,30)/t10?,13-,16-,17?/m1/s1
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n/an/a 204n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...

US Patent US9663528 (2017)


BindingDB Entry DOI: 10.7270/Q24F1SVF
More data for this
Ligand-Target Pair
Solute carrier family 22 member 2


(Homo sapiens (Human))		BDBM330039
PNG
((2R,5S,13aR)-N-(2,4-difluorobenzyl)-8-hydroxy-7,9-...)
Show SMILES Oc1c2C(=O)N3[C@H]4CC[C@H](C4)O[C@@H]3Cn2cc(C(=O)NCc2ccc(F)cc2F)c1=O
Show InChI InChI=1S/C21H19F2N3O5/c22-11-2-1-10(15(23)5-11)7-24-20(29)14-8-25-9-16-26(12-3-4-13(6-12)31-16)21(30)17(25)19(28)18(14)27/h1-2,5,8,12-13,16,28H,3-4,6-7,9H2,(H,24,29)/t12-,13+,16+/m0/s1
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Gilead Sciences Inc

US Patent


Assay Description
The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...

US Patent US9663528 (2017)


BindingDB Entry DOI: 10.7270/Q24F1SVF
More data for this
Ligand-Target Pair
Solute carrier family 22 member 2


(Homo sapiens (Human))		BDBM330040
PNG
((2S,5R,13aS)-N-(2,4-difluorobenzyl)-8-hydroxy-7,9-...)
Show SMILES Oc1c2C(=O)N3[C@@H]4CC[C@@H](C4)O[C@H]3Cn2cc(C(=O)NCc2ccc(F)cc2F)c1=O
Show InChI InChI=1S/C21H19F2N3O5/c22-11-2-1-10(15(23)5-11)7-24-20(29)14-8-25-9-16-26(12-3-4-13(6-12)31-16)21(30)17(25)19(28)18(14)27/h1-2,5,8,12-13,16,28H,3-4,6-7,9H2,(H,24,29)/t12-,13+,16+/m1/s1
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Gilead Sciences Inc

US Patent


Assay Description
The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...

US Patent US9663528 (2017)


BindingDB Entry DOI: 10.7270/Q24F1SVF
More data for this
Ligand-Target Pair
Solute carrier family 22 member 2


(Homo sapiens (Human))		BDBM330045
PNG
((2R,3S,5R,3aS)-N-(2,4-difluorobenzyl)-8-hydroxy-3-...)
Show SMILES CC1C[C@@H]2C[C@H]1OC1Cn3cc(C(=O)NCc4ccc(F)cc4F)c(=O)c(O)c3C(=O)N21
Show InChI InChI=1S/C22H21F2N3O5/c1-10-4-13-6-16(10)32-17-9-26-8-14(19(28)20(29)18(26)22(31)27(13)17)21(30)25-7-11-2-3-12(23)5-15(11)24/h2-3,5,8,10,13,16-17,29H,4,6-7,9H2,1H3,(H,25,30)/t10?,13-,16-,17?/m1/s1
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Gilead Sciences Inc

US Patent


Assay Description
The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...

US Patent US9663528 (2017)


BindingDB Entry DOI: 10.7270/Q24F1SVF
More data for this
Ligand-Target Pair
Solute carrier family 22 member 2


(Homo sapiens (Human))		BDBM330061
PNG
((1R,4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-6,8-...)
Show SMILES C[C@H]1C[C@@H]2C[C@H]1N1[C@H]2Cn2cc(C(=O)NCc3ccc(F)cc3F)c(=O)c(O)c2C1=O
Show InChI InChI=1S/C22H21F2N3O4/c1-10-4-12-5-16(10)27-17(12)9-26-8-14(19(28)20(29)18(26)22(27)31)21(30)25-7-11-2-3-13(23)6-15(11)24/h2-3,6,8,10,12,16-17,29H,4-5,7,9H2,1H3,(H,25,30)/t10-,12+,16+,17-/m0/s1
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Gilead Sciences Inc

US Patent


Assay Description
The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...

US Patent US9663528 (2017)


BindingDB Entry DOI: 10.7270/Q24F1SVF
More data for this
Ligand-Target Pair
Solute carrier family 22 member 2


(Homo sapiens (Human))		BDBM330052
PNG
((1R,4S,12aS)-7-hydroxy-6,8-dioxo-N-(2,4,6-trifluor...)
Show SMILES Oc1c2C(=O)N3[C@H]4CC[C@H](C4)[C@H]3Cn2cc(C(=O)NCc2c(F)cc(F)cc2F)c1=O
Show InChI InChI=1S/C21H18F3N3O4/c22-10-4-14(23)12(15(24)5-10)6-25-20(30)13-7-26-8-16-9-1-2-11(3-9)27(16)21(31)17(26)19(29)18(13)28/h4-5,7,9,11,16,29H,1-3,6,8H2,(H,25,30)/t9-,11+,16-/m1/s1
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Gilead Sciences Inc

US Patent


Assay Description
The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...

US Patent US9663528 (2017)


BindingDB Entry DOI: 10.7270/Q24F1SVF
More data for this
Ligand-Target Pair
Solute carrier family 22 member 2


(Homo sapiens (Human))		BDBM330048
PNG
((2R,5S,13aR)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluor...)
Show SMILES Oc1c2C(=O)N3[C@H]4CC[C@H](C4)O[C@@H]3Cn2cc(C(=O)NCc2c(F)cc(F)cc2F)c1=O
Show InChI InChI=1S/C21H18F3N3O5/c22-9-3-14(23)12(15(24)4-9)6-25-20(30)13-7-26-8-16-27(10-1-2-11(5-10)32-16)21(31)17(26)19(29)18(13)28/h3-4,7,10-11,16,29H,1-2,5-6,8H2,(H,25,30)/t10-,11+,16+/m0/s1
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Gilead Sciences Inc

US Patent


Assay Description
The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...

US Patent US9663528 (2017)


BindingDB Entry DOI: 10.7270/Q24F1SVF
More data for this
Ligand-Target Pair
Solute carrier family 22 member 2


(Homo sapiens (Human))		BDBM330043
PNG
((2S,5R,13aS)-N—((S)-1-(2,4-difluorophenyl)eth...)
Show SMILES C[C@H](NC(=O)c1cn2C[C@@H]3O[C@H]4CC[C@H](C4)N3C(=O)c2c(O)c1=O)c1ccc(F)cc1F
Show InChI InChI=1S/C22H21F2N3O5/c1-10(14-5-2-11(23)6-16(14)24)25-21(30)15-8-26-9-17-27(12-3-4-13(7-12)32-17)22(31)18(26)20(29)19(15)28/h2,5-6,8,10,12-13,17,29H,3-4,7,9H2,1H3,(H,25,30)/t10-,12+,13-,17-/m0/s1
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Gilead Sciences Inc

US Patent


Assay Description
The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...

US Patent US9663528 (2017)


BindingDB Entry DOI: 10.7270/Q24F1SVF
More data for this
Ligand-Target Pair
Solute carrier family 22 member 2


(Homo sapiens (Human))		BDBM330058
PNG
((1R,3R,11aS)-6-hydroxy-5,7-dioxo-N-(2,4,6-trifluor...)
Show SMILES Oc1c2C(=O)N3[C@H]4CC[C@H](C4)[C@H]3Cn2cc(C(=O)NCc2c(F)cc(F)cc2F)c1=O
Show InChI InChI=1S/C21H18F3N3O4/c22-10-4-14(23)12(15(24)5-10)6-25-20(30)13-7-26-8-16-9-1-2-11(3-9)27(16)21(31)17(26)19(29)18(13)28/h4-5,7,9,11,16,29H,1-3,6,8H2,(H,25,30)/t9-,11+,16-/m1/s1
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n/an/a 1.36E+3n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...

US Patent US9663528 (2017)


BindingDB Entry DOI: 10.7270/Q24F1SVF
More data for this
Ligand-Target Pair
Solute carrier family 22 member 2


(Homo sapiens (Human))		BDBM330060
PNG
((1R,3S,4R,12aR)-7-hydroxy-3-methyl-6,8-dioxo-N-(2,...)
Show SMILES C[C@H]1C[C@@H]2C[C@H]1N1[C@H]2Cn2cc(C(=O)NCc3c(F)cc(F)cc3F)c(=O)c(O)c2C1=O
Show InChI InChI=1S/C22H20F3N3O4/c1-9-2-10-3-16(9)28-17(10)8-27-7-13(19(29)20(30)18(27)22(28)32)21(31)26-6-12-14(24)4-11(23)5-15(12)25/h4-5,7,9-10,16-17,30H,2-3,6,8H2,1H3,(H,26,31)/t9-,10+,16+,17-/m0/s1
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n/an/a 1.51E+3n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...

US Patent US9663528 (2017)


BindingDB Entry DOI: 10.7270/Q24F1SVF
More data for this
Ligand-Target Pair
Solute carrier family 22 member 2


(Homo sapiens (Human))		BDBM330041
PNG
( (4R,12aS)-N-(1-(2,4-difluorophenyl)cyclopropyl)-7...)
Show SMILES C[C@@H]1CCO[C@H]2Cn3cc(C(=O)NC4(CC4)c4ccc(F)cc4F)c(=O)c(O)c3C(=O)N12
Show InChI InChI=1S/C22H21F2N3O5/c1-11-4-7-32-16-10-26-9-13(18(28)19(29)17(26)21(31)27(11)16)20(30)25-22(5-6-22)14-3-2-12(23)8-15(14)24/h2-3,8-9,11,16,29H,4-7,10H2,1H3,(H,25,30)/t11-,16+/m1/s1
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Gilead Sciences Inc

US Patent


Assay Description
The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...

US Patent US9663528 (2017)


BindingDB Entry DOI: 10.7270/Q24F1SVF
More data for this
Ligand-Target Pair
Solute carrier family 22 member 2


(Homo sapiens (Human))		BDBM330047
PNG
((1R,4S,12aR)-7-hydroxy-6,8-dioxo-N-(2,4,6-trifluor...)
Show SMILES Oc1c2C(=O)N3[C@H]4CC[C@H](C4)[C@@H]3Cn2cc(C(=O)NCc2c(F)cc(F)cc2F)c1=O
Show InChI InChI=1S/C21H18F3N3O4/c22-10-4-14(23)12(15(24)5-10)6-25-20(30)13-7-26-8-16-9-1-2-11(3-9)27(16)21(31)17(26)19(29)18(13)28/h4-5,7,9,11,16,29H,1-3,6,8H2,(H,25,30)/t9-,11+,16+/m1/s1
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Gilead Sciences Inc

US Patent


Assay Description
The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...

US Patent US9663528 (2017)


BindingDB Entry DOI: 10.7270/Q24F1SVF
More data for this
Ligand-Target Pair
Solute carrier family 22 member 2


(Homo sapiens (Human))		BDBM330059
PNG
((1S,4R,12aR)-3,3-difluoro-7-hydroxy-6,8-dioxo-N-(2...)
Show SMILES Oc1c2C(=O)N3[C@@H](Cn2cc(C(=O)NCc2c(F)cc(F)cc2F)c1=O)[C@H]1C[C@@H]3C(F)(F)C1
Show InChI InChI=1S/C21H16F5N3O4/c22-9-2-12(23)10(13(24)3-9)5-27-19(32)11-6-28-7-14-8-1-15(21(25,26)4-8)29(14)20(33)16(28)18(31)17(11)30/h2-3,6,8,14-15,31H,1,4-5,7H2,(H,27,32)/t8-,14-,15+/m0/s1
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Gilead Sciences Inc

US Patent


Assay Description
The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...

US Patent US9663528 (2017)


BindingDB Entry DOI: 10.7270/Q24F1SVF
More data for this
Ligand-Target Pair
Solute carrier family 22 member 2


(Homo sapiens (Human))		BDBM330055
PNG
((1R,4S,12aR)-7-hydroxy-6,8-dioxo-N—((R)-1-(2,...)
Show SMILES C[C@@H](NC(=O)c1cn2C[C@H]3[C@@H]4CC[C@@H](C4)N3C(=O)c2c(O)c1=O)c1c(F)cc(F)cc1F
Show InChI InChI=1S/C22H20F3N3O4/c1-9(17-14(24)5-11(23)6-15(17)25)26-21(31)13-7-27-8-16-10-2-3-12(4-10)28(16)22(32)18(27)20(30)19(13)29/h5-7,9-10,12,16,30H,2-4,8H2,1H3,(H,26,31)/t9-,10-,12+,16+/m1/s1
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n/an/a 3.83E+3n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...

US Patent US9663528 (2017)


BindingDB Entry DOI: 10.7270/Q24F1SVF
More data for this
Ligand-Target Pair
Solute carrier family 22 member 2


(Homo sapiens (Human))		BDBM330051
PNG
((1S,4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-6,8-...)
Show SMILES Oc1c2C(=O)N3[C@@H]4CC[C@@H](C4)[C@H]3Cn2cc(C(=O)NCc2ccc(F)cc2F)c1=O
Show InChI InChI=1S/C21H19F2N3O4/c22-12-3-1-11(15(23)6-12)7-24-20(29)14-8-25-9-16-10-2-4-13(5-10)26(16)21(30)17(25)19(28)18(14)27/h1,3,6,8,10,13,16,28H,2,4-5,7,9H2,(H,24,29)/t10-,13+,16+/m0/s1
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n/an/a 4.91E+3n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...

US Patent US9663528 (2017)


BindingDB Entry DOI: 10.7270/Q24F1SVF
More data for this
Ligand-Target Pair
Solute carrier family 22 member 2


(Homo sapiens (Human))		BDBM330050
PNG
((1R,4S,12aR)-N-(2,4-difluorobenzyl)-7-hydroxy-6,8-...)
Show SMILES Oc1c2C(=O)N3[C@H]4CC[C@H](C4)[C@@H]3Cn2cc(C(=O)NCc2ccc(F)cc2F)c1=O
Show InChI InChI=1S/C21H19F2N3O4/c22-12-3-1-11(15(23)6-12)7-24-20(29)14-8-25-9-16-10-2-4-13(5-10)26(16)21(30)17(25)19(28)18(14)27/h1,3,6,8,10,13,16,28H,2,4-5,7,9H2,(H,24,29)/t10-,13+,16+/m1/s1
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n/an/a 6.20E+3n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...

US Patent US9663528 (2017)


BindingDB Entry DOI: 10.7270/Q24F1SVF
More data for this
Ligand-Target Pair
Solute carrier family 22 member 2


(Homo sapiens (Human))		BDBM330044
PNG
( (2S,5R)-N—((S)-1-(2,4-difluorophenyl)-2,2,2-...)
Show SMILES Oc1c2C(=O)N3[C@@H]4CC[C@@H](C4)OC3Cn2cc(C(=O)N[C@@H](c2ccc(F)cc2F)C(F)(F)F)c1=O
Show InChI InChI=1S/C22H18F5N3O5/c23-9-1-4-12(14(24)5-9)19(22(25,26)27)28-20(33)13-7-29-8-15-30(10-2-3-11(6-10)35-15)21(34)16(29)18(32)17(13)31/h1,4-5,7,10-11,15,19,32H,2-3,6,8H2,(H,28,33)/t10-,11+,15?,19+/m1/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...

US Patent US9663528 (2017)


BindingDB Entry DOI: 10.7270/Q24F1SVF
More data for this
Ligand-Target Pair
Solute carrier family 22 member 2


(Homo sapiens (Human))		BDBM330056
PNG
((1S,3R,4R,12aR)-3-fluoro-7-hydroxy-6,8-dioxo-N-(2,...)
Show SMILES Oc1c2C(=O)N3[C@@H]4C[C@@H](C[C@H]4F)[C@@H]3Cn2cc(C(=O)NCc2c(F)cc(F)cc2F)c1=O
Show InChI InChI=1S/C21H17F4N3O4/c22-9-3-12(23)10(13(24)4-9)5-26-20(31)11-6-27-7-16-8-1-14(25)15(2-8)28(16)21(32)17(27)19(30)18(11)29/h3-4,6,8,14-16,30H,1-2,5,7H2,(H,26,31)/t8-,14-,15-,16+/m1/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...

US Patent US9663528 (2017)


BindingDB Entry DOI: 10.7270/Q24F1SVF
More data for this
Ligand-Target Pair
Solute carrier family 22 member 2


(Homo sapiens (Human))		BDBM330042
PNG
((2S,5R,13aS)-N—((R)-1-(2,4-difluorophenyl)eth...)
Show SMILES C[C@@H](NC(=O)c1cn2C[C@@H]3O[C@H]4CC[C@H](C4)N3C(=O)c2c(O)c1=O)c1ccc(F)cc1F
Show InChI InChI=1S/C22H21F2N3O5/c1-10(14-5-2-11(23)6-16(14)24)25-21(30)15-8-26-9-17-27(12-3-4-13(7-12)32-17)22(31)18(26)20(29)19(15)28/h2,5-6,8,10,12-13,17,29H,3-4,7,9H2,1H3,(H,25,30)/t10-,12-,13+,17+/m1/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...

US Patent US9663528 (2017)


BindingDB Entry DOI: 10.7270/Q24F1SVF
More data for this
Ligand-Target Pair
Solute carrier family 22 member 2


(Homo sapiens (Human))		BDBM330057
PNG
((1S,4R,12aS)-3,3-difluoro-7-hydroxy-6,8-dioxo-N-(2...)
Show SMILES Oc1c2C(=O)N3[C@H](Cn2cc(C(=O)NCc2c(F)cc(F)cc2F)c1=O)[C@H]1C[C@@H]3C(F)(F)C1
Show InChI InChI=1S/C21H16F5N3O4/c22-9-2-12(23)10(13(24)3-9)5-27-19(32)11-6-28-7-14-8-1-15(21(25,26)4-8)29(14)20(33)16(28)18(31)17(11)30/h2-3,6,8,14-15,31H,1,4-5,7H2,(H,27,32)/t8-,14+,15+/m0/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...

US Patent US9663528 (2017)


BindingDB Entry DOI: 10.7270/Q24F1SVF
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%