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Patent code US9663529

Compile Data Set for Download or QSAR
Found 96 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330062
PNG
(2-(2-Chlorophenyl)-N-(5H-chromeno[3,4-c]pyridin-8-...)
Show SMILES Clc1ccccc1CC(=O)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C20H15ClN2O2/c21-18-4-2-1-3-13(18)9-20(24)23-15-5-6-17-16-7-8-22-11-14(16)12-25-19(17)10-15/h1-8,10-11H,9,12H2,(H,23,24)
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n/an/a 5.97n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330071
PNG
(2-(2-chloro-4- fluorophenyl)-N- (5H-chromeno[3,4- ...)
Show SMILES Fc1ccc(CC(=O)Nc2ccc-3c(OCc4cnccc-34)c2)c(Cl)c1
Show InChI InChI=1S/C20H14ClFN2O2/c21-18-8-14(22)2-1-12(18)7-20(25)24-15-3-4-17-16-5-6-23-10-13(16)11-26-19(17)9-15/h1-6,8-10H,7,11H2,(H,24,25)
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n/an/a 6.27n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330067
PNG
((R)-2-amino-N- (5H-chromeno [3,4-c]pyridin-8- yl)-...)
Show SMILES N[C@@H](C(=O)Nc1ccc-2c(OCc3cnccc-23)c1)c1ccccc1
Show InChI InChI=1S/C20H17N3O2/c21-19(13-4-2-1-3-5-13)20(24)23-15-6-7-17-16-8-9-22-11-14(16)12-25-18(17)10-15/h1-11,19H,12,21H2,(H,23,24)/t19-/m1/s1
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n/an/a 9.43n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330156
PNG
(2-Phenyl-N-(9H-pyrido[3,4-b]indol-7-yl)acetamide |...)
Show SMILES O=C(Cc1ccccc1)Nc1ccc2c(c1)[nH]c1cnccc21
Show InChI InChI=1S/C19H15N3O/c23-19(10-13-4-2-1-3-5-13)21-14-6-7-15-16-8-9-20-12-18(16)22-17(15)11-14/h1-9,11-12,22H,10H2,(H,21,23)
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n/an/a 9.5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330085
PNG
(N-(5H-chromeno[3,4- c]pyridin- 8-yl)-2-(4-fluoro-2...)
Show SMILES Cc1cc(F)ccc1CC(=O)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C21H17FN2O2/c1-13-8-16(22)3-2-14(13)9-21(25)24-17-4-5-19-18-6-7-23-11-15(18)12-26-20(19)10-17/h2-8,10-11H,9,12H2,1H3,(H,24,25)
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n/an/a 11.1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330076
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-2- o-tolylacet...)
Show SMILES Cc1ccccc1CC(=O)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C21H18N2O2/c1-14-4-2-3-5-15(14)10-21(24)23-17-6-7-19-18-8-9-22-12-16(18)13-25-20(19)11-17/h2-9,11-12H,10,13H2,1H3,(H,23,24)
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n/an/a 16.7n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330070
PNG
((R)-2-amino-N-(5H- chromeno[3,4- c]pyridin-8-yl)-3...)
Show SMILES N[C@H](Cc1ccccc1)C(=O)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C21H19N3O2/c22-19(10-14-4-2-1-3-5-14)21(25)24-16-6-7-18-17-8-9-23-12-15(17)13-26-20(18)11-16/h1-9,11-12,19H,10,13,22H2,(H,24,25)/t19-/m1/s1
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n/an/a 19.9n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330155
PNG
(2-(3-Fluorophenyl)-N-(9H-pyrido[3,4-b]indol-7-yl)a...)
Show SMILES Fc1cccc(CC(=O)Nc2ccc3c(c2)[nH]c2cnccc32)c1
Show InChI InChI=1S/C19H14FN3O/c20-13-3-1-2-12(8-13)9-19(24)22-14-4-5-15-16-6-7-21-11-18(16)23-17(15)10-14/h1-8,10-11,23H,9H2,(H,22,24)
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n/an/a 21n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM263022
PNG
((S)-2-amino-N-(5H-chromeno[3,4-c]pyridin-8-yl)-2-p...)
Show SMILES N[C@H](C(=O)Nc1ccc-2c(OCc3cnccc-23)c1)c1ccccc1
Show InChI InChI=1S/C20H17N3O2/c21-19(13-4-2-1-3-5-13)20(24)23-15-6-7-17-16-8-9-22-11-14(16)12-25-18(17)10-15/h1-11,19H,12,21H2,(H,23,24)/t19-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330072
PNG
(2-(3-chlorophenyl)- N-(5H-chromeno [3,4-c]pyridin-...)
Show SMILES Clc1cccc(CC(=O)Nc2ccc-3c(OCc4cnccc-34)c2)c1
Show InChI InChI=1S/C20H15ClN2O2/c21-15-3-1-2-13(8-15)9-20(24)23-16-4-5-18-17-6-7-22-11-14(17)12-25-19(18)10-16/h1-8,10-11H,9,12H2,(H,23,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330066
PNG
(2-(2-chlorophenyl)- N-(5H-chromeno [3,4-c]pyridin-...)
Show SMILES CC(C(=O)Nc1ccc-2c(OCc3cnccc-23)c1)c1ccccc1Cl
Show InChI InChI=1S/C21H17ClN2O2/c1-13(16-4-2-3-5-19(16)22)21(25)24-15-6-7-18-17-8-9-23-11-14(17)12-26-20(18)10-15/h2-11,13H,12H2,1H3,(H,24,25)
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n/an/a 33.5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330078
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-2- (3,5-difluo...)
Show SMILES Fc1cc(F)cc(CC(=O)Nc2ccc-3c(OCc4cnccc-34)c2)c1
Show InChI InChI=1S/C20H14F2N2O2/c21-14-5-12(6-15(22)8-14)7-20(25)24-16-1-2-18-17-3-4-23-10-13(17)11-26-19(18)9-16/h1-6,8-10H,7,11H2,(H,24,25)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330087
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-2- (4-fluoroph...)
Show SMILES Fc1ccc(CC(=O)Nc2ccc-3c(OCc4cnccc-34)c2)cc1
Show InChI InChI=1S/C20H15FN2O2/c21-15-3-1-13(2-4-15)9-20(24)23-16-5-6-18-17-7-8-22-11-14(17)12-25-19(18)10-16/h1-8,10-11H,9,12H2,(H,23,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330121
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-3- phenylpropa...)
Show SMILES O=C(CCc1ccccc1)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C21H18N2O2/c24-21(9-6-15-4-2-1-3-5-15)23-17-7-8-19-18-10-11-22-13-16(18)14-25-20(19)12-17/h1-5,7-8,10-13H,6,9,14H2,(H,23,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330123
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-2- phenylaceta...)
Show SMILES O=C(Cc1ccccc1)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C20H16N2O2/c23-20(10-14-4-2-1-3-5-14)22-16-6-7-18-17-8-9-21-12-15(17)13-24-19(18)11-16/h1-9,11-12H,10,13H2,(H,22,23)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330154
PNG
(2-(3-Chlorophenyl)-N-(9H-pyrido[3,4-b]indol-7-yl)a...)
Show SMILES Clc1cccc(CC(=O)Nc2ccc3c(c2)[nH]c2cnccc32)c1
Show InChI InChI=1S/C19H14ClN3O/c20-13-3-1-2-12(8-13)9-19(24)22-14-4-5-15-16-6-7-21-11-18(16)23-17(15)10-14/h1-8,10-11,23H,9H2,(H,22,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330153
PNG
(3-(3-Methoxyphenyl)-N-(9H-pyrido[3,4-b]indol-7-yl)...)
Show SMILES COc1cccc(CCC(=O)Nc2ccc3c(c2)[nH]c2cnccc32)c1
Show InChI InChI=1S/C21H19N3O2/c1-26-16-4-2-3-14(11-16)5-8-21(25)23-15-6-7-17-18-9-10-22-13-20(18)24-19(17)12-15/h2-4,6-7,9-13,24H,5,8H2,1H3,(H,23,25)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330107
PNG
(N-(5H-chromeno[3,4- c]pyridin- 8-yl)-2-hydroxy-2- ...)
Show SMILES OC(C(=O)Nc1ccc-2c(OCc3cnccc-23)c1)c1ccccc1
Show InChI InChI=1S/C20H16N2O3/c23-19(13-4-2-1-3-5-13)20(24)22-15-6-7-17-16-8-9-21-11-14(16)12-25-18(17)10-15/h1-11,19,23H,12H2,(H,22,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330075
PNG
(N-(5H-chromeno [3,4-c]pyridin- 8-yl)-2-(2,4- dichl...)
Show SMILES Clc1ccc(CC(=O)Nc2ccc-3c(OCc4cnccc-34)c2)c(Cl)c1
Show InChI InChI=1S/C20H14Cl2N2O2/c21-14-2-1-12(18(22)8-14)7-20(25)24-15-3-4-17-16-5-6-23-10-13(16)11-26-19(17)9-15/h1-6,8-10H,7,11H2,(H,24,25)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330069
PNG
((S)-2-amino-N-(5H- chromeno[3,4- c]pyridin-8-yl)-3...)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C21H19N3O2/c22-19(10-14-4-2-1-3-5-14)21(25)24-16-6-7-18-17-8-9-23-12-15(17)13-26-20(18)11-16/h1-9,11-12,19H,10,13,22H2,(H,24,25)/t19-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330108
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-2- (furan-2-yl...)
Show SMILES O=C(Cc1ccco1)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C18H14N2O3/c21-18(9-14-2-1-7-22-14)20-13-3-4-16-15-5-6-19-10-12(15)11-23-17(16)8-13/h1-8,10H,9,11H2,(H,20,21)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330133
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-2,3- dihydro-1...)
Show SMILES O=C(Nc1ccc-2c(OCc3cnccc-23)c1)C1Cc2ccccc2C1
Show InChI InChI=1S/C22H18N2O2/c25-22(16-9-14-3-1-2-4-15(14)10-16)24-18-5-6-20-19-7-8-23-12-17(19)13-26-21(20)11-18/h1-8,11-12,16H,9-10,13H2,(H,24,25)
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n/an/a 58.7n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330088
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-3- ((4-(4-cyan...)
Show SMILES O=C(Nc1ccc-2c(OCc3cnccc-23)c1)c1cccc(Cn2cc(cn2)-c2ccc(cc2)C#N)c1
Show InChI InChI=1S/C30H21N5O2/c31-14-20-4-6-22(7-5-20)24-16-33-35(18-24)17-21-2-1-3-23(12-21)30(36)34-26-8-9-28-27-10-11-32-15-25(27)19-37-29(28)13-26/h1-13,15-16,18H,17,19H2,(H,34,36)
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n/an/a 60.8n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330073
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-2-m- tolylacet...)
Show SMILES Cc1cccc(CC(=O)Nc2ccc-3c(OCc4cnccc-34)c2)c1
Show InChI InChI=1S/C21H18N2O2/c1-14-3-2-4-15(9-14)10-21(24)23-17-5-6-19-18-7-8-22-12-16(18)13-25-20(19)11-17/h2-9,11-12H,10,13H2,1H3,(H,23,24)
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n/an/a 74.5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330063
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-3- phenoxyprop...)
Show SMILES O=C(CCOc1ccccc1)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C21H18N2O3/c24-21(9-11-25-17-4-2-1-3-5-17)23-16-6-7-19-18-8-10-22-13-15(18)14-26-20(19)12-16/h1-8,10,12-13H,9,11,14H2,(H,23,24)
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n/an/a 82.2n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330077
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-2- (3,5-dimeth...)
Show SMILES Cc1cc(C)cc(CC(=O)Nc2ccc-3c(OCc4cnccc-34)c2)c1
Show InChI InChI=1S/C22H20N2O2/c1-14-7-15(2)9-16(8-14)10-22(25)24-18-3-4-20-19-5-6-23-12-17(19)13-26-21(20)11-18/h3-9,11-12H,10,13H2,1-2H3,(H,24,25)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330119
PNG
(N-(5H-chromeno[3,4- c]pyridin- 8-yl)-3-(4- hydroxy...)
Show SMILES Oc1ccc(CCC(=O)Nc2ccc-3c(OCc4cnccc-34)c2)cc1
Show InChI InChI=1S/C21H18N2O3/c24-17-5-1-14(2-6-17)3-8-21(25)23-16-4-7-19-18-9-10-22-12-15(18)13-26-20(19)11-16/h1-2,4-7,9-12,24H,3,8,13H2,(H,23,25)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330065
PNG
((R)-2-amino-N-(5H- chromeno[3,4- c]pyridin-8-yl)-4...)
Show SMILES N[C@H](CCc1ccccc1)C(=O)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C22H21N3O2/c23-20(9-6-15-4-2-1-3-5-15)22(26)25-17-7-8-19-18-10-11-24-13-16(18)14-27-21(19)12-17/h1-5,7-8,10-13,20H,6,9,14,23H2,(H,25,26)/t20-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330150
PNG
(US9663529, Example III-4 | benzyl 5H- chromeno[3,4...)
Show SMILES O=C(Nc1ccc-2c(OCc3cnccc-23)c1)OCc1ccccc1
Show InChI InChI=1S/C20H16N2O3/c23-20(25-12-14-4-2-1-3-5-14)22-16-6-7-18-17-8-9-21-11-15(17)13-24-19(18)10-16/h1-11H,12-13H2,(H,22,23)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330074
PNG
(2-(4-chlorophenyl)- N-(5H-chromeno [3,4-c]pyridin-...)
Show SMILES Clc1ccc(CC(=O)Nc2ccc-3c(OCc4cnccc-34)c2)cc1
Show InChI InChI=1S/C20H15ClN2O2/c21-15-3-1-13(2-4-15)9-20(24)23-16-5-6-18-17-7-8-22-11-14(17)12-25-19(18)10-16/h1-8,10-11H,9,12H2,(H,23,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330083
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-2-(3- (trifluo...)
Show SMILES FC(F)(F)c1cccc(CC(=O)Nc2ccc-3c(OCc4cnccc-34)c2)c1
Show InChI InChI=1S/C21H15F3N2O2/c22-21(23,24)15-3-1-2-13(8-15)9-20(27)26-16-4-5-18-17-6-7-25-11-14(17)12-28-19(18)10-16/h1-8,10-11H,9,12H2,(H,26,27)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330082
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-2- (2,6-dichlo...)
Show SMILES Clc1cccc(Cl)c1CC(=O)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C20H14Cl2N2O2/c21-17-2-1-3-18(22)16(17)9-20(25)24-13-4-5-15-14-6-7-23-10-12(14)11-26-19(15)8-13/h1-8,10H,9,11H2,(H,24,25)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330137
PNG
(1-(5H-chromeno[3,4- c]pyridin- 8-yl)-3- phenethylu...)
Show SMILES O=C(NCCc1ccccc1)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C21H19N3O2/c25-21(23-11-8-15-4-2-1-3-5-15)24-17-6-7-19-18-9-10-22-13-16(18)14-26-20(19)12-17/h1-7,9-10,12-13H,8,11,14H2,(H2,23,24,25)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330097
PNG
(N-(5H-chromeno [3,4-c]pyridin- 8-yl)-2-methyl-2- p...)
Show SMILES CC(C)(C(=O)Nc1ccc-2c(OCc3cnccc-23)c1)c1ccccc1
Show InChI InChI=1S/C22H20N2O2/c1-22(2,16-6-4-3-5-7-16)21(25)24-17-8-9-19-18-10-11-23-13-15(18)14-26-20(19)12-17/h3-13H,14H2,1-2H3,(H,24,25)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330095
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-2- (pyridin-4-...)
Show SMILES O=C(Cc1ccncc1)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C19H15N3O2/c23-19(9-13-3-6-20-7-4-13)22-15-1-2-17-16-5-8-21-11-14(16)12-24-18(17)10-15/h1-8,10-11H,9,12H2,(H,22,23)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330141
PNG
(1-(5H-chromeno[3,4- c]pyridin- 8-yl)-3-(2- fluorop...)
Show SMILES Fc1ccccc1CCNC(=O)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C21H18FN3O2/c22-19-4-2-1-3-14(19)7-10-24-21(26)25-16-5-6-18-17-8-9-23-12-15(17)13-27-20(18)11-16/h1-6,8-9,11-12H,7,10,13H2,(H2,24,25,26)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330144
PNG
(1-(3-chlorophenethyl)- 3-(5H- chromeno[3,4- c]pyri...)
Show SMILES Clc1cccc(CCNC(=O)Nc2ccc-3c(OCc4cnccc-34)c2)c1
Show InChI InChI=1S/C21H18ClN3O2/c22-16-3-1-2-14(10-16)6-9-24-21(26)25-17-4-5-19-18-7-8-23-12-15(18)13-27-20(19)11-17/h1-5,7-8,10-12H,6,9,13H2,(H2,24,25,26)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330064
PNG
((S)-2-amino-N-(5H- chromeno[3,4- c]pyridin-8-yl)-4...)
Show SMILES N[C@@H](CCc1ccccc1)C(=O)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C22H21N3O2/c23-20(9-6-15-4-2-1-3-5-15)22(26)25-17-7-8-19-18-10-11-24-13-16(18)14-27-21(19)12-17/h1-5,7-8,10-13,20H,6,9,14,23H2,(H,25,26)/t20-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330103
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-2- (pyridin-3-...)
Show SMILES O=C(Cc1cccnc1)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C19H15N3O2/c23-19(8-13-2-1-6-20-10-13)22-15-3-4-17-16-5-7-21-11-14(16)12-24-18(17)9-15/h1-7,9-11H,8,12H2,(H,22,23)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330086
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-2-(4- (methylt...)
Show SMILES CSc1ccc(CC(=O)Nc2ccc-3c(OCc4cnccc-34)c2)cc1
Show InChI InChI=1S/C21H18N2O2S/c1-26-17-5-2-14(3-6-17)10-21(24)23-16-4-7-19-18-8-9-22-12-15(18)13-25-20(19)11-16/h2-9,11-12H,10,13H2,1H3,(H,23,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330132
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-2- (pyridin-4-...)
Show SMILES O=C(Nc1ccc-2c(OCc3cnccc-23)c1)c1csc(n1)-c1ccncc1
Show InChI InChI=1S/C21H14N4O2S/c26-20(18-12-28-21(25-18)13-3-6-22-7-4-13)24-15-1-2-17-16-5-8-23-10-14(16)11-27-19(17)9-15/h1-10,12H,11H2,(H,24,26)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330098
PNG
(3-(4-chlorophenyl)- N-(5H-chromeno [3,4-c]pyridin-...)
Show SMILES Clc1ccc(CCC(=O)Nc2ccc-3c(OCc4cnccc-34)c2)cc1
Show InChI InChI=1S/C21H17ClN2O2/c22-16-4-1-14(2-5-16)3-8-21(25)24-17-6-7-19-18-9-10-23-12-15(18)13-26-20(19)11-17/h1-2,4-7,9-12H,3,8,13H2,(H,24,25)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330129
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-2- (3,4-dichlo...)
Show SMILES Clc1ccc(CC(=O)Nc2ccc-3c(OCc4cnccc-34)c2)cc1Cl
Show InChI InChI=1S/C20H14Cl2N2O2/c21-17-4-1-12(7-18(17)22)8-20(25)24-14-2-3-16-15-5-6-23-10-13(15)11-26-19(16)9-14/h1-7,9-10H,8,11H2,(H,24,25)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330094
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-2- (pyridin-2-...)
Show SMILES O=C(Cc1ccccn1)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C19H15N3O2/c23-19(10-14-3-1-2-7-21-14)22-15-4-5-17-16-6-8-20-11-13(16)12-24-18(17)9-15/h1-9,11H,10,12H2,(H,22,23)
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n/an/a 367n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330084
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-2- (3-fluoro-5...)
Show SMILES Fc1cc(CC(=O)Nc2ccc-3c(OCc4cnccc-34)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C21H14F4N2O2/c22-15-6-12(5-14(8-15)21(23,24)25)7-20(28)27-16-1-2-18-17-3-4-26-10-13(17)11-29-19(18)9-16/h1-6,8-10H,7,11H2,(H,27,28)
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n/an/a 368n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330157
PNG
(2-(3-Cyanophenyl)-N-(9H-pyrido[3,4-b]indol-7-yl)ac...)
Show SMILES O=C(Cc1cccc(c1)C#N)Nc1ccc2c(c1)[nH]c1cnccc21
Show InChI InChI=1S/C20H14N4O/c21-11-14-3-1-2-13(8-14)9-20(25)23-15-4-5-16-17-6-7-22-12-19(17)24-18(16)10-15/h1-8,10,12,24H,9H2,(H,23,25)
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n/an/a 383n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330135
PNG
(N-(5H-Chromeno[3,4-c]pyridin-8-yl)indoline-1-carbo...)
Show SMILES O=C(Nc1ccc-2c(OCc3cnccc-23)c1)N1CCc2ccccc12
Show InChI InChI=1S/C21H17N3O2/c25-21(24-10-8-14-3-1-2-4-19(14)24)23-16-5-6-18-17-7-9-22-12-15(17)13-26-20(18)11-16/h1-7,9,11-12H,8,10,13H2,(H,23,25)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330079
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-2- (3,5-dimeth...)
Show SMILES COc1cc(CC(=O)Nc2ccc-3c(OCc4cnccc-34)c2)cc(OC)c1
Show InChI InChI=1S/C22H20N2O4/c1-26-17-7-14(8-18(11-17)27-2)9-22(25)24-16-3-4-20-19-5-6-23-12-15(19)13-28-21(20)10-16/h3-8,10-12H,9,13H2,1-2H3,(H,24,25)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330096
PNG
(3-acetamido-N-(5H- chromeno[3,4-c] pyridin-8-yl) b...)
Show SMILES CC(=O)Nc1cccc(c1)C(=O)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C21H17N3O3/c1-13(25)23-16-4-2-3-14(9-16)21(26)24-17-5-6-19-18-7-8-22-11-15(18)12-27-20(19)10-17/h2-11H,12H2,1H3,(H,23,25)(H,24,26)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330128
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-3,3- diphenylp...)
Show SMILES O=C(CC(c1ccccc1)c1ccccc1)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C27H22N2O2/c30-27(16-25(19-7-3-1-4-8-19)20-9-5-2-6-10-20)29-22-11-12-24-23-13-14-28-17-21(23)18-31-26(24)15-22/h1-15,17,25H,16,18H2,(H,29,30)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330092
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-2-(4- methoxyp...)
Show SMILES COc1ccc(CC(=O)Nc2ccc-3c(OCc4cnccc-34)c2)cc1
Show InChI InChI=1S/C21H18N2O3/c1-25-17-5-2-14(3-6-17)10-21(24)23-16-4-7-19-18-8-9-22-12-15(18)13-26-20(19)11-16/h2-9,11-12H,10,13H2,1H3,(H,23,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330101
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-4- sulfamoylbe...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C19H15N3O4S/c20-27(24,25)15-4-1-12(2-5-15)19(23)22-14-3-6-17-16-7-8-21-10-13(16)11-26-18(17)9-14/h1-10H,11H2,(H,22,23)(H2,20,24,25)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330136
PNG
(1-(2-chlorophenyl)- 3-(5H- chromeno[3,4- c]pyridin...)
Show SMILES Clc1ccccc1NC(=O)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C19H14ClN3O2/c20-16-3-1-2-4-17(16)23-19(24)22-13-5-6-15-14-7-8-21-10-12(14)11-25-18(15)9-13/h1-10H,11H2,(H2,22,23,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330134
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-1H- benzo[d]im...)
Show SMILES O=C(Nc1ccc-2c(OCc3cnccc-23)c1)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C20H14N4O2/c25-20(19-23-16-3-1-2-4-17(16)24-19)22-13-5-6-15-14-7-8-21-10-12(14)11-26-18(15)9-13/h1-10H,11H2,(H,22,25)(H,23,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330117
PNG
(US9663529, Example I-56 | methyl 4-(5H- chromeno[3...)
Show SMILES COC(=O)c1ccc(cc1)C(=O)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C21H16N2O4/c1-26-21(25)14-4-2-13(3-5-14)20(24)23-16-6-7-18-17-8-9-22-11-15(17)12-27-19(18)10-16/h2-11H,12H2,1H3,(H,23,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330100
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-2- (pyridin-3-...)
Show SMILES O=C(Nc1ccc-2c(OCc3cnccc-23)c1)c1csc(n1)-c1cccnc1
Show InChI InChI=1S/C21H14N4O2S/c26-20(18-12-28-21(25-18)13-2-1-6-22-9-13)24-15-3-4-17-16-5-7-23-10-14(16)11-27-19(17)8-15/h1-10,12H,11H2,(H,24,26)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330093
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-4- phenylbutan...)
Show SMILES O=C(CCCc1ccccc1)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C22H20N2O2/c25-22(8-4-7-16-5-2-1-3-6-16)24-18-9-10-20-19-11-12-23-14-17(19)15-26-21(20)13-18/h1-3,5-6,9-14H,4,7-8,15H2,(H,24,25)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330146
PNG
(1-(2-(benzo[d][1,3] dioxol-5-yl) ethyl)-3-(5H- chr...)
Show SMILES O=C(NCCc1ccc2OCOc2c1)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C22H19N3O4/c26-22(24-8-5-14-1-4-19-21(9-14)29-13-28-19)25-16-2-3-18-17-6-7-23-11-15(17)12-27-20(18)10-16/h1-4,6-7,9-11H,5,8,12-13H2,(H2,24,25,26)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330099
PNG
(US9663529, Example I-38 | methyl 3-(5H- chromeno[3...)
Show SMILES COC(=O)c1cccc(c1)C(=O)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C21H16N2O4/c1-26-21(25)14-4-2-3-13(9-14)20(24)23-16-5-6-18-17-7-8-22-11-15(17)12-27-19(18)10-16/h2-11H,12H2,1H3,(H,23,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330142
PNG
(1-(5H-chromeno[3,4- c]pyridin- 8-yl)-3-(2,2- diphe...)
Show SMILES O=C(NCC(c1ccccc1)c1ccccc1)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C27H23N3O2/c31-27(29-17-25(19-7-3-1-4-8-19)20-9-5-2-6-10-20)30-22-11-12-24-23-13-14-28-16-21(23)18-32-26(24)15-22/h1-16,25H,17-18H2,(H2,29,30,31)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330143
PNG
(1-(4-chlorophenethyl)- 3-(5H- chromeno[3,4- c]pyri...)
Show SMILES Clc1ccc(CCNC(=O)Nc2ccc-3c(OCc4cnccc-34)c2)cc1
Show InChI InChI=1S/C21H18ClN3O2/c22-16-3-1-14(2-4-16)7-10-24-21(26)25-17-5-6-19-18-8-9-23-12-15(18)13-27-20(19)11-17/h1-6,8-9,11-12H,7,10,13H2,(H2,24,25,26)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330109
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-3- (1H-imidazo...)
Show SMILES O=C(CCn1ccnc1)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C18H16N4O2/c23-18(4-7-22-8-6-20-12-22)21-14-1-2-16-15-3-5-19-10-13(15)11-24-17(16)9-14/h1-3,5-6,8-10,12H,4,7,11H2,(H,21,23)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330130
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-2- (4-(trifluo...)
Show SMILES FC(F)(F)c1ccc(CC(=O)Nc2ccc-3c(OCc4cnccc-34)c2)cc1
Show InChI InChI=1S/C21H15F3N2O2/c22-21(23,24)15-3-1-13(2-4-15)9-20(27)26-16-5-6-18-17-7-8-25-11-14(17)12-28-19(18)10-16/h1-8,10-11H,9,12H2,(H,26,27)
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n/an/a 1.08E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330148
PNG
(2-chlorophenyl 5H- chromeno[3,4-c] pyridin-8-ylcar...)
Show SMILES Clc1ccccc1OC(=O)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C19H13ClN2O3/c20-16-3-1-2-4-17(16)25-19(23)22-13-5-6-15-14-7-8-21-10-12(14)11-24-18(15)9-13/h1-10H,11H2,(H,22,23)
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n/an/a 1.09E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330131
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-2-(4- (4-oxoqu...)
Show SMILES O=C(Cc1ccc(cc1)-n1cnc2ccccc2c1=O)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C28H20N4O3/c33-27(31-20-7-10-23-22-11-12-29-15-19(22)16-35-26(23)14-20)13-18-5-8-21(9-6-18)32-17-30-25-4-2-1-3-24(25)28(32)34/h1-12,14-15,17H,13,16H2,(H,31,33)
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n/an/a 1.13E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330147
PNG
(Phenyl 5H-chromeno[3,4-c]pyridin-8-ylcarbamate | U...)
Show SMILES O=C(Nc1ccc-2c(OCc3cnccc-23)c1)Oc1ccccc1
Show InChI InChI=1S/C19H14N2O3/c22-19(24-15-4-2-1-3-5-15)21-14-6-7-17-16-8-9-20-11-13(16)12-23-18(17)10-14/h1-11H,12H2,(H,21,22)
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n/an/a 1.13E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330118
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-3- (4-methoxyp...)
Show SMILES COc1ccc(CCC(=O)Nc2ccc-3c(OCc4cnccc-34)c2)cc1
Show InChI InChI=1S/C22H20N2O3/c1-26-18-6-2-15(3-7-18)4-9-22(25)24-17-5-8-20-19-10-11-23-13-16(19)14-27-21(20)12-17/h2-3,5-8,10-13H,4,9,14H2,1H3,(H,24,25)
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n/an/a 1.14E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330112
PNG
(2-chloro-N-(5H- chromeno[3,4- c]pyridin-8- yl)benz...)
Show SMILES Clc1ccccc1C(=O)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C19H13ClN2O2/c20-17-4-2-1-3-16(17)19(23)22-13-5-6-15-14-7-8-21-10-12(14)11-24-18(15)9-13/h1-10H,11H2,(H,22,23)
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n/an/a 1.15E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330126
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl) biphenyl-2- ca...)
Show SMILES O=C(Nc1ccc-2c(OCc3cnccc-23)c1)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C25H18N2O2/c28-25(23-9-5-4-8-20(23)17-6-2-1-3-7-17)27-19-10-11-22-21-12-13-26-15-18(21)16-29-24(22)14-19/h1-15H,16H2,(H,27,28)
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n/an/a 1.22E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330110
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-2- (pyrazin-2-...)
Show SMILES O=C(Cc1cnccn1)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C18H14N4O2/c23-18(8-14-10-20-5-6-21-14)22-13-1-2-16-15-3-4-19-9-12(15)11-24-17(16)7-13/h1-7,9-10H,8,11H2,(H,22,23)
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n/an/a 1.25E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330139
PNG
(1-(5H-chromeno[3,4- c]pyridin- 8-yl)-3- (pyridin-3...)
Show SMILES O=C(Nc1cccnc1)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C18H14N4O2/c23-18(22-14-2-1-6-19-10-14)21-13-3-4-16-15-5-7-20-9-12(15)11-24-17(16)8-13/h1-10H,11H2,(H2,21,22,23)
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n/an/a 1.42E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330105
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl) thiazole- 4-ca...)
Show SMILES O=C(Nc1ccc-2c(OCc3cnccc-23)c1)c1cscn1
Show InChI InChI=1S/C16H11N3O2S/c20-16(14-8-22-9-18-14)19-11-1-2-13-12-3-4-17-6-10(12)7-21-15(13)5-11/h1-6,8-9H,7H2,(H,19,20)
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n/an/a 1.45E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330140
PNG
(1-(5H-chromeno[3,4- c]pyridin- 8-yl)-3-(4- methoxy...)
Show SMILES COc1ccc(CCNC(=O)Nc2ccc-3c(OCc4cnccc-34)c2)cc1
Show InChI InChI=1S/C22H21N3O3/c1-27-18-5-2-15(3-6-18)8-11-24-22(26)25-17-4-7-20-19-9-10-23-13-16(19)14-28-21(20)12-17/h2-7,9-10,12-13H,8,11,14H2,1H3,(H2,24,25,26)
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n/an/a 1.61E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330081
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-2-(4- (methyls...)
Show SMILES CS(=O)(=O)c1ccc(CC(=O)Nc2ccc-3c(OCc4cnccc-34)c2)cc1
Show InChI InChI=1S/C21H18N2O4S/c1-28(25,26)17-5-2-14(3-6-17)10-21(24)23-16-4-7-19-18-8-9-22-12-15(18)13-27-20(19)11-16/h2-9,11-12H,10,13H2,1H3,(H,23,24)
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n/an/a 1.76E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330106
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl) pyrimidine-5- ...)
Show SMILES O=C(Nc1ccc-2c(OCc3cnccc-23)c1)c1cncnc1
Show InChI InChI=1S/C17H12N4O2/c22-17(11-6-19-10-20-7-11)21-13-1-2-15-14-3-4-18-8-12(14)9-23-16(15)5-13/h1-8,10H,9H2,(H,21,22)
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n/an/a 1.98E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330090
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-4- (methylsulf...)
Show SMILES CS(=O)(=O)c1ccc(cc1)C(=O)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C20H16N2O4S/c1-27(24,25)16-5-2-13(3-6-16)20(23)22-15-4-7-18-17-8-9-21-11-14(17)12-26-19(18)10-15/h2-11H,12H2,1H3,(H,22,23)
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n/an/a 2.05E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330104
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-3- (methylsulf...)
Show SMILES CS(=O)(=O)c1cccc(c1)C(=O)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C20H16N2O4S/c1-27(24,25)16-4-2-3-13(9-16)20(23)22-15-5-6-18-17-7-8-21-11-14(17)12-26-19(18)10-15/h2-11H,12H2,1H3,(H,22,23)
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n/an/a 2.19E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330145
PNG
(1-(5H-chromeno[3,4- c]pyridin- 8-yl)-3-(5- methyl-...)
Show SMILES Cc1onc(c1NC(=O)Nc1ccc-2c(OCc3cnccc-23)c1)-c1ccccc1
Show InChI InChI=1S/C23H18N4O3/c1-14-21(22(27-30-14)15-5-3-2-4-6-15)26-23(28)25-17-7-8-19-18-9-10-24-12-16(18)13-29-20(19)11-17/h2-12H,13H2,1H3,(H2,25,26,28)
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n/an/a 2.24E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330124
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-4- (dimethylam...)
Show SMILES CN(C)c1ccc(cc1)C(=O)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C21H19N3O2/c1-24(2)17-6-3-14(4-7-17)21(25)23-16-5-8-19-18-9-10-22-12-15(18)13-26-20(19)11-16/h3-12H,13H2,1-2H3,(H,23,25)
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n/an/a 2.37E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330138
PNG
(1-(3-chlorophenyl)-3- (5H- chromeno[3,4- c]pyridin...)
Show SMILES Clc1cccc(NC(=O)Nc2ccc-3c(OCc4cnccc-34)c2)c1
Show InChI InChI=1S/C19H14ClN3O2/c20-13-2-1-3-14(8-13)22-19(24)23-15-4-5-17-16-6-7-21-10-12(16)11-25-18(17)9-15/h1-10H,11H2,(H2,22,23,24)
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n/an/a 2.37E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330080
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-2- (3,4-dimeth...)
Show SMILES COc1ccc(CC(=O)Nc2ccc-3c(OCc4cnccc-34)c2)cc1OC
Show InChI InChI=1S/C22H20N2O4/c1-26-19-6-3-14(9-21(19)27-2)10-22(25)24-16-4-5-18-17-7-8-23-12-15(17)13-28-20(18)11-16/h3-9,11-12H,10,13H2,1-2H3,(H,24,25)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330115
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-4- cyanobenzam...)
Show SMILES O=C(Nc1ccc-2c(OCc3cnccc-23)c1)c1ccc(cc1)C#N
Show InChI InChI=1S/C20H13N3O2/c21-10-13-1-3-14(4-2-13)20(24)23-16-5-6-18-17-7-8-22-11-15(17)12-25-19(18)9-16/h1-9,11H,12H2,(H,23,24)
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n/an/a 2.56E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330127
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-3- methoxybenz...)
Show SMILES COc1cccc(c1)C(=O)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C20H16N2O3/c1-24-16-4-2-3-13(9-16)20(23)22-15-5-6-18-17-7-8-21-11-14(17)12-25-19(18)10-15/h2-11H,12H2,1H3,(H,22,23)
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n/an/a 2.59E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330102
PNG
(N-(5H-chromeno[3,4- c]pyridin- 8-yl)-1,2,3- thiadi...)
Show SMILES O=C(Nc1ccc-2c(OCc3cnccc-23)c1)c1csnn1
Show InChI InChI=1S/C15H10N4O2S/c20-15(13-8-22-19-18-13)17-10-1-2-12-11-3-4-16-6-9(11)7-21-14(12)5-10/h1-6,8H,7H2,(H,17,20)
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n/an/a 2.76E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330149
PNG
(4-chlorophenyl 5H- chromeno[3,4-c] pyridin-8-ylcar...)
Show SMILES Clc1ccc(OC(=O)Nc2ccc-3c(OCc4cnccc-34)c2)cc1
Show InChI InChI=1S/C19H13ClN2O3/c20-13-1-4-15(5-2-13)25-19(23)22-14-3-6-17-16-7-8-21-10-12(16)11-24-18(17)9-14/h1-10H,11H2,(H,22,23)
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n/an/a 2.81E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330091
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl) pyrazine- 2-ca...)
Show SMILES O=C(Nc1ccc-2c(OCc3cnccc-23)c1)c1cnccn1
Show InChI InChI=1S/C17H12N4O2/c22-17(15-9-19-5-6-20-15)21-12-1-2-14-13-3-4-18-8-11(13)10-23-16(14)7-12/h1-9H,10H2,(H,21,22)
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n/an/a 2.94E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330125
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-1- methyl-1H-p...)
Show SMILES Cn1cccc1C(=O)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C18H15N3O2/c1-21-8-2-3-16(21)18(22)20-13-4-5-15-14-6-7-19-10-12(14)11-23-17(15)9-13/h2-10H,11H2,1H3,(H,20,22)
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n/an/a 2.96E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330116
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-4- methoxybenz...)
Show SMILES COc1ccc(cc1)C(=O)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C20H16N2O3/c1-24-16-5-2-13(3-6-16)20(23)22-15-4-7-18-17-8-9-21-11-14(17)12-25-19(18)10-15/h2-11H,12H2,1H3,(H,22,23)
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n/an/a 3.25E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330089
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-4- fluorobenza...)
Show SMILES Fc1ccc(cc1)C(=O)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C19H13FN2O2/c20-14-3-1-12(2-4-14)19(23)22-15-5-6-17-16-7-8-21-10-13(16)11-24-18(17)9-15/h1-10H,11H2,(H,22,23)
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n/an/a 3.44E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330113
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-3- fluorobenza...)
Show SMILES Fc1cccc(c1)C(=O)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C19H13FN2O2/c20-14-3-1-2-12(8-14)19(23)22-15-4-5-17-16-6-7-21-10-13(16)11-24-18(17)9-15/h1-10H,11H2,(H,22,23)
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n/an/a 3.56E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330151
PNG
(US9663529, Example III-5 | naphthalen-2-yl 5H- chr...)
Show SMILES O=C(Nc1ccc-2c(OCc3cnccc-23)c1)Oc1ccc2ccccc2c1
Show InChI InChI=1S/C23H16N2O3/c26-23(28-19-7-5-15-3-1-2-4-16(15)11-19)25-18-6-8-21-20-9-10-24-13-17(20)14-27-22(21)12-18/h1-13H,14H2,(H,25,26)
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n/an/a 3.73E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330120
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-2- (1H-tetrazo...)
Show SMILES O=C(Cc1nnn[nH]1)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C15H12N6O2/c22-15(6-14-18-20-21-19-14)17-10-1-2-12-11-3-4-16-7-9(11)8-23-13(12)5-10/h1-5,7H,6,8H2,(H,17,22)(H,18,19,20,21)
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n/an/a 3.82E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330152
PNG
(US9663529, Example III-6 | naphthalen-1-yl 5H- chr...)
Show SMILES O=C(Nc1ccc-2c(OCc3cnccc-23)c1)Oc1cccc2ccccc12
Show InChI InChI=1S/C23H16N2O3/c26-23(28-21-7-3-5-15-4-1-2-6-19(15)21)25-17-8-9-20-18-10-11-24-13-16(18)14-27-22(20)12-17/h1-13H,14H2,(H,25,26)
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n/an/a 4.08E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330114
PNG
(3-chloro-N-(5H- chromeno[3,4- c]pyridin-8- yl)benz...)
Show SMILES Clc1cccc(c1)C(=O)Nc1ccc-2c(OCc3cnccc-23)c1
Show InChI InChI=1S/C19H13ClN2O2/c20-14-3-1-2-12(8-14)19(23)22-15-4-5-17-16-6-7-21-10-13(16)11-24-18(17)9-15/h1-10H,11H2,(H,22,23)
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n/an/a 4.50E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330122
PNG
(N-(5H-chromeno[3,4- c]pyridin-8-yl)-2- naphthamide...)
Show SMILES O=C(Nc1ccc-2c(OCc3cnccc-23)c1)c1ccc2ccccc2c1
Show InChI InChI=1S/C23H16N2O2/c26-23(17-6-5-15-3-1-2-4-16(15)11-17)25-19-7-8-21-20-9-10-24-13-18(20)14-27-22(21)12-19/h1-13H,14H2,(H,25,26)
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n/an/a 4.72E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM330111
PNG
(N-(5H-chromeno[3,4- c]pyridin- 8-yl)benzamide | US...)
Show SMILES O=C(Nc1ccc-2c(OCc3cnccc-23)c1)c1ccccc1
Show InChI InChI=1S/C19H14N2O2/c22-19(13-4-2-1-3-5-13)21-15-6-7-17-16-8-9-20-11-14(16)12-23-18(17)10-15/h1-11H,12H2,(H,21,22)
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n/an/a 4.81E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9663529 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%