BindingDB logo
myBDB logout

Patent code US9669029

Compile Data Set for Download or QSAR
Found 114 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PED10A


(Homo sapiens (human))
BDBM164395
PNG
(US9669029, 98 8-Methoxy-5-methyl-2-{2-[1-(2-morpho...)
Show SMILES COC1=CC=C(C)N2N=C(CCc3nc(cn3CCN3CCOCC3)-c3cccs3)NC12
Show InChI InChI=1S/C23H30N6O2S/c1-17-5-6-19(30-2)23-25-21(26-29(17)23)7-8-22-24-18(20-4-3-15-32-20)16-28(22)10-9-27-11-13-31-14-12-27/h3-6,15-16,23H,7-14H2,1-2H3,(H,25,26)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.330n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164399
PNG
(US9669029, 102 5,8-Dimethyl-2-[2-(1-methyl-4-thiop...)
Show SMILES CC1=CN=C(C)C2NC(CCc3nc(cn3C)-c3ccco3)=NN12
Show InChI InChI=1S/C17H20N6O/c1-11-9-18-12(2)17-20-15(21-23(11)17)6-7-16-19-13(10-22(16)3)14-5-4-8-24-14/h4-5,8-10,17H,6-7H2,1-3H3,(H,20,21)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.390n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164544
PNG
(US9669029, 115 5,8-Dimethyl-2-[2-(1-methyl-4-thiaz...)
Show SMILES CC1=CC=C(C)N2N=C(CCc3nc(cn3C)-c3cscn3)NC12
Show InChI InChI=1S/C17H20N6S/c1-11-4-5-12(2)23-17(11)20-15(21-23)6-7-16-19-13(8-22(16)3)14-9-24-10-18-14/h4-5,8-10,17H,6-7H2,1-3H3,(H,20,21)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.400n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164545
PNG
(US9669029, 116 5,8-Dimethyl-2-[2-(1-methyl-4-pyrim...)
Show SMILES CC1=CN=C(C)C2NC(CCc3nc(cn3C)-c3cncnc3)=NN12
Show InChI InChI=1S/C17H20N8/c1-11-6-20-12(2)17-22-15(23-25(11)17)4-5-16-21-14(9-24(16)3)13-7-18-10-19-8-13/h6-10,17H,4-5H2,1-3H3,(H,22,23)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.440n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164549
PNG
(US9669029, 117 5,8-Dimethyl-2-[2-(1-methyl-4-pyraz...)
Show SMILES CC1=CN=C(C)C2NC(CCc3nc(cn3C)-c3cnccn3)=NN12
Show InChI InChI=1S/C17H20N8/c1-11-8-20-12(2)17-22-15(23-25(11)17)4-5-16-21-14(10-24(16)3)13-9-18-6-7-19-13/h6-10,17H,4-5H2,1-3H3,(H,22,23)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.520n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164283
PNG
(US9669029, 33 5-Methyl-2-[2-(4-thiophen-2-yl-1H-im...)
Show SMILES CC1=CC=CC2NC(CCc3nc(c[nH]3)-c3cccs3)=NN12
Show InChI InChI=1S/C16H17N5S/c1-11-4-2-6-16-19-15(20-21(11)16)8-7-14-17-10-12(18-14)13-5-3-9-22-13/h2-6,9-10,16H,7-8H2,1H3,(H,17,18)(H,19,20)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.540n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164560
PNG
(US9669029, 118 5,8-Dimethyl-2-[2-(1-methyl-4-pyrid...)
Show SMILES CC1=CN=C(C)C2NC(CCc3nc(cn3C)-c3ccncc3)=NN12
Show InChI InChI=1S/C18H21N7/c1-12-10-20-13(2)18-22-16(23-25(12)18)4-5-17-21-15(11-24(17)3)14-6-8-19-9-7-14/h6-11,18H,4-5H2,1-3H3,(H,22,23)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.550n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164284
PNG
(US9669029, 34 8-Methyl-2-[2-(4-thiophen-2-yl-1H-im...)
Show SMILES CC1=CC=CN2N=C(CCc3nc(c[nH]3)-c3cccs3)NC12
Show InChI InChI=1S/C16H17N5S/c1-11-4-2-8-21-16(11)19-15(20-21)7-6-14-17-10-12(18-14)13-5-3-9-22-13/h2-5,8-10,16H,6-7H2,1H3,(H,17,18)(H,19,20)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.990n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164391
PNG
(US9669029, 94 5,8-Dimethyl-2-[2-(1-methyl-4-thioph...)
Show SMILES CC1=CC=C(C)N2N=C(CCc3nc(cn3C)-c3cccs3)NC12
Show InChI InChI=1S/C18H21N5S/c1-12-6-7-13(2)23-18(12)20-16(21-23)8-9-17-19-14(11-22(17)3)15-5-4-10-24-15/h4-7,10-11,18H,8-9H2,1-3H3,(H,20,21)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164354
PNG
(US9669029, 62 8-Methoxy-5-methyl-2-[2-(1-methyl-4-...)
Show SMILES COC1=CC=C(C)N2N=C(CCc3nc(cn3C)-c3cccs3)NC12
Show InChI InChI=1S/C18H21N5OS/c1-12-6-7-14(24-3)18-20-16(21-23(12)18)8-9-17-19-13(11-22(17)2)15-5-4-10-25-15/h4-7,10-11,18H,8-9H2,1-3H3,(H,20,21)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164392
PNG
(US9669029, 95 8-Methoxy-5-methyl-2-[2-(1-propyl-4-...)
Show SMILES CCCn1cc(nc1CCC1=NN2C(N1)C(OC)=CC=C2C)-c1cccs1
Show InChI InChI=1S/C20H25N5OS/c1-4-11-24-13-15(17-6-5-12-27-17)21-19(24)10-9-18-22-20-16(26-3)8-7-14(2)25(20)23-18/h5-8,12-13,20H,4,9-11H2,1-3H3,(H,22,23)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164543
PNG
(US9669029, 114 5,8-Dimethyl-2-[2-(1-methyl-4-thiaz...)
Show SMILES CC1=CN=C(C)C2NC(CCc3nc(cn3C)-c3cscn3)=NN12
Show InChI InChI=1S/C16H19N7S/c1-10-6-17-11(2)16-20-14(21-23(10)16)4-5-15-19-12(7-22(15)3)13-8-24-9-18-13/h6-9,16H,4-5H2,1-3H3,(H,20,21)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.29n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164354
PNG
(US9669029, 62 8-Methoxy-5-methyl-2-[2-(1-methyl-4-...)
Show SMILES COC1=CC=C(C)N2N=C(CCc3nc(cn3C)-c3cccs3)NC12
Show InChI InChI=1S/C18H21N5OS/c1-12-6-7-14(24-3)18-20-16(21-23(12)18)8-9-17-19-13(11-22(17)2)15-5-4-10-25-15/h4-7,10-11,18H,8-9H2,1-3H3,(H,20,21)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.5n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164394
PNG
(US9669029, 97 4-{2-[2-(8-Methoxy-5-methyl-[1,2,4]t...)
Show SMILES COC1=CC=C(C)N2N=C(CCc3nc(cn3CCCC#N)-c3cncs3)NC12
Show InChI InChI=1S/C20H23N7OS/c1-14-5-6-16(28-2)20-24-18(25-27(14)20)7-8-19-23-15(17-11-22-13-29-17)12-26(19)10-4-3-9-21/h5-6,11-13,20H,3-4,7-8,10H2,1-2H3,(H,24,25)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.70n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164396
PNG
(US9669029, 99 8-Methoxy-5-methyl-2-[2-(1-methyl-4-...)
Show SMILES COC1=CC=C(C)N2N=C(CCc3nc(cn3C)-c3ccsc3)NC12
Show InChI InChI=1S/C18H21N5OS/c1-12-4-5-15(24-3)18-20-16(21-23(12)18)6-7-17-19-14(10-22(17)2)13-8-9-25-11-13/h4-5,8-11,18H,6-7H2,1-3H3,(H,20,21)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.70n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164495
PNG
(US9669029, 103 5,8-Dimethyl-2-[2-(1-methyl-4-thiaz...)
Show SMILES CC1=CC=C(C)N2N=C(CCc3nc(cn3C)-c3nccs3)NC12
Show InChI InChI=1S/C17H20N6S/c1-11-4-5-12(2)23-16(11)20-14(21-23)6-7-15-19-13(10-22(15)3)17-18-8-9-24-17/h4-5,8-10,16H,6-7H2,1-3H3,(H,20,21)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.30n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164501
PNG
(US9669029, 104 5,8-Dimethyl-2-[2-(1-methyl-4-thiaz...)
Show SMILES CC1=CN=C(C)C2NC(CCc3nc(cn3C)-c3nccs3)=NN12
Show InChI InChI=1S/C16H19N7S/c1-10-8-18-11(2)15-20-13(21-23(10)15)4-5-14-19-12(9-22(14)3)16-17-6-7-24-16/h6-9,15H,4-5H2,1-3H3,(H,20,21)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.70n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164316
PNG
(US9669029, 50 8-Methoxy-5-methyl-2-[(E)-2-(1-methy...)
Show SMILES COC1=CC=C(C)N2N=C(NC12)\C=C/c1nc(cn1C)-c1cccs1
Show InChI InChI=1S/C18H19N5OS/c1-12-6-7-14(24-3)18-20-16(21-23(12)18)8-9-17-19-13(11-22(17)2)15-5-4-10-25-15/h4-11,18H,1-3H3,(H,20,21)/b9-8-
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.70n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164350
PNG
(US9669029, 59 (R)-1-Chloro-3-{2-[2-(5-methyl-[1,2,...)
Show SMILES CC1=CC=CC2NC(CCc3nc(cn3C[C@@H](O)CCl)-c3cccs3)=NN12
Show InChI InChI=1S/C19H22ClN5OS/c1-13-4-2-6-19-22-17(23-25(13)19)7-8-18-21-15(16-5-3-9-27-16)12-24(18)11-14(26)10-20/h2-6,9,12,14,19,26H,7-8,10-11H2,1H3,(H,22,23)/t14-,19?/m0/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.80n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164536
PNG
(US9669029, 111 2-[2-(4-Furan-3-yl-1-methyl-1H-imid...)
Show SMILES CC1=CN=C(C)C2NC(CCc3nc(cn3C)-c3ccoc3)=NN12
Show InChI InChI=1S/C17H20N6O/c1-11-8-18-12(2)17-20-15(21-23(11)17)4-5-16-19-14(9-22(16)3)13-6-7-24-10-13/h6-10,17H,4-5H2,1-3H3,(H,20,21)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.90n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164511
PNG
(US9669029, 105 8-Methoxy-5-methyl-2-{2-[1-methyl-4...)
Show SMILES COC1=CC=C(C)N2N=C(CCc3nc(cn3C)-c3cocc3C)NC12
Show InChI InChI=1S/C19H23N5O2/c1-12-10-26-11-14(12)15-9-23(3)18(20-15)8-7-17-21-19-16(25-4)6-5-13(2)24(19)22-17/h5-6,9-11,19H,7-8H2,1-4H3,(H,21,22)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.10n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM173102
PNG
(US9096589, 5,7-Dimethyl-2-[2-(1-propyl-4-thiophen-...)
Show SMILES CCCn1cc(nc1CCc1cn2c(C)cc(C)nc2n1)-c1cccs1
Show InChI InChI=1S/C20H23N5S/c1-4-9-24-13-17(18-6-5-10-26-18)23-19(24)8-7-16-12-25-15(3)11-14(2)21-20(25)22-16/h5-6,10-13H,4,7-9H2,1-3H3
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.40n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164397
PNG
(US9669029, 100 2-[2-(4-Furan-3-yl-1-methyl-1H-imid...)
Show SMILES COC1=CC=C(C)N2N=C(CCc3nc(cn3C)-c3ccoc3)NC12
Show InChI InChI=1S/C18H21N5O2/c1-12-4-5-15(24-3)18-20-16(21-23(12)18)6-7-17-19-14(10-22(17)2)13-8-9-25-11-13/h4-5,8-11,18H,6-7H2,1-3H3,(H,20,21)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164393
PNG
(US9669029, 96 8-Methoxy-5-methyl-2-[2-(1-prop-2-yn...)
Show SMILES COC1=CC=C(C)N2N=C(CCc3nc(cn3CC#C)-c3cncs3)NC12
Show InChI InChI=1S/C19H20N6OS/c1-4-9-24-11-14(16-10-20-12-27-16)21-18(24)8-7-17-22-19-15(26-3)6-5-13(2)25(19)23-17/h1,5-6,10-12,19H,7-9H2,2-3H3,(H,22,23)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.10n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164317
PNG
(US9669029, 51 5,7-Dimethyl-2-[2-(1-methyl-4-thioph...)
Show SMILES CC1=NC2NC(CCc3nc(cn3C)-c3cccs3)=NN2C(C)=C1
Show InChI InChI=1S/C17H20N6S/c1-11-9-12(2)23-17(18-11)20-15(21-23)6-7-16-19-13(10-22(16)3)14-5-4-8-24-14/h4-5,8-10,17H,6-7H2,1-3H3,(H,20,21)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.20n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164534
PNG
(US9669029, 109 5,8-Dimethyl-2-{2-[1-methyl-4-(5-me...)
Show SMILES Cc1ccc(o1)-c1cn(C)c(CCC2=NN3C(N2)C(C)=CC=C3C)n1
Show InChI InChI=1S/C19H23N5O/c1-12-5-6-13(2)24-19(12)21-17(22-24)9-10-18-20-15(11-23(18)4)16-8-7-14(3)25-16/h5-8,11,19H,9-10H2,1-4H3,(H,21,22)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.20n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164328
PNG
(US9669029, 52 8-Methoxy-2-[2-(1-methyl-4-thiophen-...)
Show SMILES COC1=CC=CN2N=C(CCc3nc(cn3C)-c3cccs3)NC12
Show InChI InChI=1S/C17H19N5OS/c1-21-11-12(14-6-4-10-24-14)18-16(21)8-7-15-19-17-13(23-2)5-3-9-22(17)20-15/h3-6,9-11,17H,7-8H2,1-2H3,(H,19,20)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.5n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164290
PNG
(US9669029, 40 5-Methyl-2-[2-(4-thiophen-3-yl-1H-im...)
Show SMILES CC1=CC=CC2NC(CCc3ncc(n3)-c3ccsc3)=NN12
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.70n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164282
PNG
(US9669029, 32 1-(4-Chloro-phenyl)-2-{2-[2-(5,7-dim...)
Show SMILES Cc1cc(C)n2cc(CCc3nc(cn3C(C)(O)c3ccc(Cl)cc3)-c3cncs3)nc2n1
Show InChI InChI=1S/C24H23ClN6OS/c1-15-10-16(2)30-12-19(28-23(30)27-15)8-9-22-29-20(21-11-26-14-33-21)13-31(22)24(3,32)17-4-6-18(25)7-5-17/h4-7,10-14,32H,8-9H2,1-3H3
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.70n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164532
PNG
(US9669029, 107 5,8-Dimethyl-2-[2-(1-methyl-4-pyrid...)
Show SMILES CCCn1cc(nc1CCC1=NN2C(N1)C(C)=CC=C2C)-c1cccnc1
Show InChI InChI=1S/C21H26N6/c1-4-12-26-14-18(17-6-5-11-22-13-17)23-20(26)10-9-19-24-21-15(2)7-8-16(3)27(21)25-19/h5-8,11,13-14,21H,4,9-10,12H2,1-3H3,(H,24,25)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.70n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164285
PNG
(US9669029, 35 (S)-2-{2-[2-(5-Methyl-[1,2,4]triazol...)
Show SMILES CC[C@@H](O)n1cc(nc1CCC1=NN2C(N1)C=CC=C2C)-c1cccs1
Show InChI InChI=1S/C19H23N5OS/c1-3-19(25)23-12-14(15-7-5-11-26-15)20-17(23)10-9-16-21-18-8-4-6-13(2)24(18)22-16/h4-8,11-12,18-19,25H,3,9-10H2,1-2H3,(H,21,22)/t18?,19-/m1/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.40n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164398
PNG
(US9669029, 101 5,8-Dimethyl-2-{2-[1-methyl-4-(5-me...)
Show SMILES Cc1ccc(o1)-c1cn(C)c(CCC2=NN3C(N2)C(C)=NC=C3C)n1
Show InChI InChI=1S/C18H22N6O/c1-11-9-19-13(3)18-21-16(22-24(11)18)7-8-17-20-14(10-23(17)4)15-6-5-12(2)25-15/h5-6,9-10,18H,7-8H2,1-4H3,(H,21,22)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.80n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM173105
PNG
(US9096589, 5,7-Dimethyl-2-{2-[1-(3-methyl-butyl)-4...)
Show SMILES CC(C)CCn1cc(nc1CCc1cn2c(C)cc(C)nc2n1)-c1cccs1
Show InChI InChI=1S/C22H27N5S/c1-15(2)9-10-26-14-19(20-6-5-11-28-20)25-21(26)8-7-18-13-27-17(4)12-16(3)23-22(27)24-18/h5-6,11-15H,7-10H2,1-4H3
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6.80n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164539
PNG
(US9669029, 113 5,8-Dimethyl-2-[2-(1-methyl-4-thiaz...)
Show SMILES CC1=CN=C(C)C2NC(CCc3nc(cn3C)-c3cncs3)=NN12
Show InChI InChI=1S/C16H19N7S/c1-10-6-18-11(2)16-20-14(21-23(10)16)4-5-15-19-12(8-22(15)3)13-7-17-9-24-13/h6-9,16H,4-5H2,1-3H3,(H,20,21)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.90n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164286
PNG
(US9669029, 36 1-Methoxy-3-{2-[2-(5-methyl-[1,2,4]t...)
Show SMILES COCC(O)Cn1cc(nc1CCC1=NN2C(N1)C=CC=C2C)-c1cccs1
Show InChI InChI=1S/C20H25N5O2S/c1-14-5-3-7-20-22-18(23-25(14)20)8-9-19-21-16(17-6-4-10-28-17)12-24(19)11-15(26)13-27-2/h3-7,10,12,15,20,26H,8-9,11,13H2,1-2H3,(H,22,23)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7.5n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM173096
PNG
(US9096589, 5,7-Dimethyl-2-[2-(4-thiophen-2-yl-1H-i...)
Show SMILES Cc1cc(C)n2cc(CCc3nc(c[nH]3)-c3cccs3)nc2n1
Show InChI InChI=1S/C17H17N5S/c1-11-8-12(2)22-10-13(20-17(22)19-11)5-6-16-18-9-14(21-16)15-4-3-7-23-15/h3-4,7-10H,5-6H2,1-2H3,(H,18,21)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7.60n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164272
PNG
(US9669029, 22 1-{2-[2-(5,7-Dimethyl-imidazo[1,2-a]...)
Show SMILES CCOCC(O)Cn1cc(nc1CCc1cn2c(C)cc(C)nc2n1)-c1cccs1
Show InChI InChI=1S/C22H27N5O2S/c1-4-29-14-18(28)12-26-13-19(20-6-5-9-30-20)25-21(26)8-7-17-11-27-16(3)10-15(2)23-22(27)24-17/h5-6,9-11,13,18,28H,4,7-8,12,14H2,1-3H3
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7.90n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164380
PNG
(US9669029, 83 1-Methoxy-3-{2-[2-(8-methyl-[1,2,4]t...)
Show SMILES COCC(O)Cn1cc(nc1CCC1=NN2C=CC=C(C)C2N1)-c1cccs1
Show InChI InChI=1S/C20H25N5O2S/c1-14-5-3-9-25-20(14)22-18(23-25)7-8-19-21-16(17-6-4-10-28-17)12-24(19)11-15(26)13-27-2/h3-6,9-10,12,15,20,26H,7-8,11,13H2,1-2H3,(H,22,23)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 8.40n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM173100
PNG
(US9096589, (S)-2-{2-[2-(5,7-Dimethyl-imidazo[1,2-a...)
Show SMILES C[C@@H](CO)n1cc(nc1CCc1cn2c(C)cc(C)nc2n1)-c1cccs1
Show InChI InChI=1S/C20H23N5OS/c1-13-9-14(2)25-10-16(22-20(25)21-13)6-7-19-23-17(18-5-4-8-27-18)11-24(19)15(3)12-26/h4-5,8-11,15,26H,6-7,12H2,1-3H3/t15-/m0/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 8.80n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164372
PNG
(US9669029, 75 [((S)-2-Hydroxy-3-{2-[2-(5-methyl-[1...)
Show SMILES CN(CC#N)C[C@H](O)Cn1cc(nc1CCC1=NN2C(N1)C=CC=C2C)-c1cccs1
Show InChI InChI=1S/C22H27N7OS/c1-16-5-3-7-22-25-20(26-29(16)22)8-9-21-24-18(19-6-4-12-31-19)15-28(21)14-17(30)13-27(2)11-10-23/h3-7,12,15,17,22,30H,8-9,11,13-14H2,1-2H3,(H,25,26)/t17-,22?/m0/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 8.80n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM173083
PNG
(US9096589, 5,7-Dimethyl-2-[(E)-2-(1-methyl-4-thiop...)
Show SMILES Cc1cc(C)n2cc(\C=C\c3nc(cn3C)-c3cccs3)nc2n1
Show InChI InChI=1S/C18H17N5S/c1-12-9-13(2)23-10-14(20-18(23)19-12)6-7-17-21-15(11-22(17)3)16-5-4-8-24-16/h4-11H,1-3H3/b7-6+
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 8.80n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164533
PNG
(US9669029, 108 5,8-Dimethyl-2-[2-(1-methyl-4-pyrid...)
Show SMILES CC1=CN=C(C)C2NC(CCc3nc(cn3C)-c3cccnc3)=NN12
Show InChI InChI=1S/C18H21N7/c1-12-9-20-13(2)18-22-16(23-25(12)18)6-7-17-21-15(11-24(17)3)14-5-4-8-19-10-14/h4-5,8-11,18H,6-7H2,1-3H3,(H,22,23)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 8.90n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164381
PNG
(US9669029, 84 5-Methyl-2-[2-(1-methyl-4-thiophen-2...)
Show SMILES CC1=CC=CC2NC(CCc3nc(cn3C)-c3cccs3)=NN12
Show InChI InChI=1S/C17H19N5S/c1-12-5-3-7-17-19-15(20-22(12)17)8-9-16-18-13(11-21(16)2)14-6-4-10-23-14/h3-7,10-11,17H,8-9H2,1-2H3,(H,19,20)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 9.20n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164388
PNG
(US9669029, 91 8-Methoxy-5-methyl-2-[2-(1-methyl-4-...)
Show SMILES COC1=CC=C(C)N2N=C(CCc3nc(cn3C)-c3cncs3)NC12
Show InChI InChI=1S/C17H20N6OS/c1-11-4-5-13(24-3)17-20-15(21-23(11)17)6-7-16-19-12(9-22(16)2)14-8-18-10-25-14/h4-5,8-10,17H,6-7H2,1-3H3,(H,20,21)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 9.20n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164266
PNG
(US9669029, 16 5,7-Dimethyl-2-{2-[4-thiophen-2-yl-1...)
Show SMILES Cc1cc(C)n2cc(CCc3nc(cn3COCC[Si](C)(C)C)-c3-[s]ccc3)nc2n1
Show InChI InChI=1S/C23H31N5OSSi/c1-17-13-18(2)28-14-19(25-23(28)24-17)8-9-22-26-20(21-7-6-11-30-21)15-27(22)16-29-10-12-31(3,4)5/h6-7,11,13-15H,8-10,12,16H2,1-5H3
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 9.60n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164291
PNG
(US9669029, 41 5-Methyl-2-[2-(4-pyridin-3-yl-1H-imi...)
Show SMILES CC1=CC=CC2NC(CCc3ncc(n3)-c3cccnc3)=NN12
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 9.60n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164291
PNG
(US9669029, 41 5-Methyl-2-[2-(4-pyridin-3-yl-1H-imi...)
Show SMILES CC1=CC=CC2NC(CCc3ncc(n3)-c3cccnc3)=NN12
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 9.60n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164277
PNG
(US9669029, 27 2-[2-(1-Isobutyl-4-thiophen-2-yl-1H-...)
Show SMILES CCC(C)n1cc(nc1CCc1cn2c(C)cc(C)nc2n1)-c1cccs1
Show InChI InChI=1S/C21H25N5S/c1-5-15(3)25-13-18(19-7-6-10-27-19)24-20(25)9-8-17-12-26-16(4)11-14(2)22-21(26)23-17/h6-7,10-13,15H,5,8-9H2,1-4H3
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 12n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164531
PNG
(US9669029, 106 5,8-Dimethyl-2-[2-(1-methyl-4-thiaz...)
Show SMILES CC1=CN=C(C)N2N=C(CCc3nc(cn3C)-c3nccs3)NC12
Show InChI InChI=1S/C16H19N7S/c1-10-8-18-11(2)23-15(10)20-13(21-23)4-5-14-19-12(9-22(14)3)16-17-6-7-24-16/h6-9,15H,4-5H2,1-3H3,(H,20,21)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 12n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM173108
PNG
(US9096589, 1-{2-[2-(5,7-Dimethyl-imidazo[1,2-a]pyr...)
Show SMILES Cc1cc(C)n2cc(CCc3nc(cn3CC(O)CF)-c3cccs3)nc2n1
Show InChI InChI=1S/C20H22FN5OS/c1-13-8-14(2)26-10-15(23-20(26)22-13)5-6-19-24-17(18-4-3-7-28-18)12-25(19)11-16(27)9-21/h3-4,7-8,10,12,16,27H,5-6,9,11H2,1-2H3
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 14n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164371
PNG
(US9669029, 74 (S)-1-{2-[2-(5-Methyl-[1,2,4]triazol...)
Show SMILES CC1=CC=CC2NC(CCc3nc(cn3C[C@@H](O)CN3CCOCC3)-c3cccs3)=NN12
Show InChI InChI=1S/C23H30N6O2S/c1-17-4-2-6-23-25-21(26-29(17)23)7-8-22-24-19(20-5-3-13-32-20)16-28(22)15-18(30)14-27-9-11-31-12-10-27/h2-6,13,16,18,23,30H,7-12,14-15H2,1H3,(H,25,26)/t18-,23?/m0/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 14n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164382
PNG
(US9669029, 85 8-Methyl-2-[2-(1-methyl-4-thiophen-2...)
Show SMILES CC1=CC=CN2N=C(CCc3nc(cn3C)-c3cccs3)NC12
Show InChI InChI=1S/C17H19N5S/c1-12-5-3-9-22-17(12)19-15(20-22)7-8-16-18-13(11-21(16)2)14-6-4-10-23-14/h3-6,9-11,17H,7-8H2,1-2H3,(H,19,20)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 15n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164365
PNG
(US9669029, 68 (S)-1-[(2-Hydroxy-ethyl)-methyl-amin...)
Show SMILES CN(CCO)C[C@H](O)Cn1cc(nc1CCC1=NN2C(N1)C=CC=C2C)-c1cccs1
Show InChI InChI=1S/C22H30N6O2S/c1-16-5-3-7-22-24-20(25-28(16)22)8-9-21-23-18(19-6-4-12-31-19)15-27(21)14-17(30)13-26(2)10-11-29/h3-7,12,15,17,22,29-30H,8-11,13-14H2,1-2H3,(H,24,25)/t17-,22?/m0/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 16n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164329
PNG
(US9669029, 53 8-Methoxy-2-[2-(1-methyl-4-thiophen-...)
Show SMILES COC1=CC=CN2N=C(CCc3nc(cn3C)-c3ccsc3)NC12
Show InChI InChI=1S/C17H19N5OS/c1-21-10-13(12-7-9-24-11-12)18-16(21)6-5-15-19-17-14(23-2)4-3-8-22(17)20-15/h3-4,7-11,17H,5-6H2,1-2H3,(H,19,20)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 16n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164538
PNG
(US9669029, 112 8-Methoxy-5-methyl-2-{2-[1-methyl-4...)
Show SMILES COC1=CC=C(C)N2N=C(CCc3nc(cn3C)-c3ccc(C)o3)NC12
Show InChI InChI=1S/C19H23N5O2/c1-12-5-7-16(25-4)19-21-17(22-24(12)19)9-10-18-20-14(11-23(18)3)15-8-6-13(2)26-15/h5-8,11,19H,9-10H2,1-4H3,(H,21,22)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164389
PNG
(US9669029, 92 8-Methoxy-5-methyl-2-[2-(1-methyl-4-...)
Show SMILES CCCn1cc(nc1CCC1=NN2C(N1)C(OC)=CC=C2C)-c1cccnc1
Show InChI InChI=1S/C21H26N6O/c1-4-12-26-14-17(16-6-5-11-22-13-16)23-20(26)10-9-19-24-21-18(28-3)8-7-15(2)27(21)25-19/h5-8,11,13-14,21H,4,9-10,12H2,1-3H3,(H,24,25)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 24n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164244
PNG
(US9669029, 5 2-[(E)-2-(4-Furan-2-yl-1-methyl-1H-im...)
Show SMILES Cc1cc(C)n2cc(\C=C\c3nc(cn3C)-c3-[o]ccc3)nc2n1
Show InChI InChI=1S/C18H17N5O/c1-12-9-13(2)23-10-14(20-18(23)19-12)6-7-17-21-15(11-22(17)3)16-5-4-8-24-16/h4-11H,1-3H3/b7-6+
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 25n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164244
PNG
(US9669029, 5 2-[(E)-2-(4-Furan-2-yl-1-methyl-1H-im...)
Show SMILES Cc1cc(C)n2cc(\C=C\c3nc(cn3C)-c3-[o]ccc3)nc2n1
Show InChI InChI=1S/C18H17N5O/c1-12-9-13(2)23-10-14(20-18(23)19-12)6-7-17-21-15(11-22(17)3)16-5-4-8-24-16/h4-11H,1-3H3/b7-6+
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 25n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164378
PNG
(US9669029, 81 8-Methoxy-2-[2-(4-thiophen-2-yl-1H-i...)
Show SMILES COC1=CC=CN2N=C(CCc3ncc(n3)-c3cccs3)NC12
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 28n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164369
PNG
(US9669029, 72 (S)-1-(2-Hydroxy-ethylamino)-3-{2-[2...)
Show SMILES CC1=CC=CC2NC(CCc3nc(cn3C[C@@H](O)CNCCO)-c3cccs3)=NN12
Show InChI InChI=1S/C21H28N6O2S/c1-15-4-2-6-21-24-19(25-27(15)21)7-8-20-23-17(18-5-3-11-30-18)14-26(20)13-16(29)12-22-9-10-28/h2-6,11,14,16,21-22,28-29H,7-10,12-13H2,1H3,(H,24,25)/t16-,21?/m0/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 30n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM173081
PNG
(US9096589, 5,7-Dimethyl-2-[2-(1-methyl-4-thiophen-...)
Show SMILES Cc1cc(C)n2cc(CCc3nc(cn3C)-c3ccsc3)nc2n1
Show InChI InChI=1S/C18H19N5S/c1-12-8-13(2)23-9-15(20-18(23)19-12)4-5-17-21-16(10-22(17)3)14-6-7-24-11-14/h6-11H,4-5H2,1-3H3
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 33n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164289
PNG
(US9669029, 39 5-Methyl-2-{2-[4-(5-methyl-furan-2-y...)
Show SMILES Cc1ccc(o1)-c1cnc(CCC2=NN3C(N2)C=CC=C3C)n1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 34n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164386
PNG
(US9669029, 89 8-Methyl-2-[2-(1-methyl-4-thiazol-5-...)
Show SMILES CC1=CC=CN2N=C(CCc3nc(cn3C)-c3cncs3)NC12
Show InChI InChI=1S/C16H18N6S/c1-11-4-3-7-22-16(11)19-14(20-22)5-6-15-18-12(9-21(15)2)13-8-17-10-23-13/h3-4,7-10,16H,5-6H2,1-2H3,(H,19,20)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 36n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164328
PNG
(US9669029, 52 8-Methoxy-2-[2-(1-methyl-4-thiophen-...)
Show SMILES COC1=CC=CN2N=C(CCc3nc(cn3C)-c3cccs3)NC12
Show InChI InChI=1S/C17H19N5OS/c1-21-11-12(14-6-4-10-24-14)18-16(21)8-7-15-19-17-13(23-2)5-3-9-22(17)20-15/h3-6,9-11,17H,7-8H2,1-2H3,(H,19,20)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 36n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM173098
PNG
(US9096589, 5,7-Dimethyl-2-{2-[1-(2-morpholin-4-yl-...)
Show SMILES Cc1cc(C)n2cc(CCc3nc(cn3CCN3CCOCC3)-c3cccs3)nc2n1
Show InChI InChI=1S/C23H28N6OS/c1-17-14-18(2)29-15-19(25-23(29)24-17)5-6-22-26-20(21-4-3-13-31-21)16-28(22)8-7-27-9-11-30-12-10-27/h3-4,13-16H,5-12H2,1-2H3
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 36n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164337
PNG
(US9669029, 54 8-Methoxy-2-[2-(1-methyl-4-thiazol-5...)
Show SMILES COC1=CC=CN2N=C(CCc3nc(cn3C)-c3cncs3)NC12
Show InChI InChI=1S/C16H18N6OS/c1-21-9-11(13-8-17-10-24-13)18-15(21)6-5-14-19-16-12(23-2)4-3-7-22(16)20-14/h3-4,7-10,16H,5-6H2,1-2H3,(H,19,20)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 36n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164347
PNG
(US9669029, 57 8-Methoxy-2-{2-[1-methyl-4-(4-methyl...)
Show SMILES COC1=CC=CN2N=C(CCc3nc(cn3C)-c3cscc3C)NC12
Show InChI InChI=1S/C18H21N5OS/c1-12-10-25-11-13(12)14-9-22(2)17(19-14)7-6-16-20-18-15(24-3)5-4-8-23(18)21-16/h4-5,8-11,18H,6-7H2,1-3H3,(H,20,21)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 37n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164535
PNG
(US9669029, 110 5,7-Dimethyl-2-{2-[1-methyl-4-(5-me...)
Show SMILES Cc1ccc(o1)-c1cn(C)c(CCC2=NN3C(N2)N=C(C)C=C3C)n1
Show InChI InChI=1S/C18H22N6O/c1-11-9-12(2)24-18(19-11)21-16(22-24)7-8-17-20-14(10-23(17)4)15-6-5-13(3)25-15/h5-6,9-10,18H,7-8H2,1-4H3,(H,21,22)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 38n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164387
PNG
(US9669029, 90 5-Methyl-2-[2-(1-methyl-4-thiazol-5-...)
Show SMILES CC1=CC=CC2NC(CCc3nc(cn3C)-c3cncs3)=NN12
Show InChI InChI=1S/C16H18N6S/c1-11-4-3-5-16-19-14(20-22(11)16)6-7-15-18-12(9-21(15)2)13-8-17-10-23-13/h3-5,8-10,16H,6-7H2,1-2H3,(H,19,20)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 39n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164375
PNG
(US9669029, 78 5,7-Dimethyl-2-[2-(1-methyl-4-pyridi...)
Show SMILES CC1=NC2NC(CCc3nc(cn3C)-c3cccnc3)=NN2C(C)=C1
Show InChI InChI=1S/C18H21N7/c1-12-9-13(2)25-18(20-12)22-16(23-25)6-7-17-21-15(11-24(17)3)14-5-4-8-19-10-14/h4-5,8-11,18H,6-7H2,1-3H3,(H,22,23)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 44n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164293
PNG
(US9669029, 43 5-Methyl-2-{2-[4-(4-methyl-thiophen-...)
Show SMILES Cc1cscc1-c1cnc(CCC2=NN3C(N2)C=CC=C3C)n1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 45n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM173099
PNG
(US9096589, 5,7-Dimethyl-2-[2-(1-methyl-4-thiophen-...)
Show SMILES Cc1cc(C)n2cc(CCc3nc(cn3C)-c3cccs3)nc2n1
Show InChI InChI=1S/C18H19N5S/c1-12-9-13(2)23-10-14(20-18(23)19-12)6-7-17-21-15(11-22(17)3)16-5-4-8-24-16/h4-5,8-11H,6-7H2,1-3H3
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 45n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164275
PNG
(US9669029, 25 2-[2-(1-Cyclopentyl-4-thiophen-2-yl-...)
Show SMILES c1nc2ncccn2n1
Show InChI InChI=1S/C5H4N4/c1-2-6-5-7-4-8-9(5)3-1/h1-4H
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 46n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164288
PNG
(US9669029, 38 2-{(E)-2-[4-Furan-2-yl-1-(2-trimethy...)
Show SMILES CC1=CC=CC2NC(\C=C/c3nc(cn3COCC[Si](C)(C)C)-c3ccco3)=NN12
Show InChI InChI=1S/C22H29N5O2Si/c1-17-7-5-9-22-24-20(25-27(17)22)10-11-21-23-18(19-8-6-12-29-19)15-26(21)16-28-13-14-30(2,3)4/h5-12,15,22H,13-14,16H2,1-4H3,(H,24,25)/b11-10-
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 46n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164366
PNG
(US9669029, 69 (S)-1-Isopropylamino-3-{2-[2-(5-meth...)
Show SMILES CC(C)NC[C@H](O)Cn1cc(nc1CCC1=NN2C(N1)C=CC=C2C)-c1cccs1
Show InChI InChI=1S/C22H30N6OS/c1-15(2)23-12-17(29)13-27-14-18(19-7-5-11-30-19)24-21(27)10-9-20-25-22-8-4-6-16(3)28(22)26-20/h4-8,11,14-15,17,22-23,29H,9-10,12-13H2,1-3H3,(H,25,26)/t17-,22?/m0/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 46n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164357
PNG
(US9669029, 65 (S)-1-Dimethylamino-3-{2-[2-(5-methy...)
Show SMILES CN(C)C[C@H](O)Cn1cc(nc1CCC1=NN2C(N1)C=CC=C2C)-c1cccs1
Show InChI InChI=1S/C21H28N6OS/c1-15-6-4-8-21-23-19(24-27(15)21)9-10-20-22-17(18-7-5-11-29-18)14-26(20)13-16(28)12-25(2)3/h4-8,11,14,16,21,28H,9-10,12-13H2,1-3H3,(H,23,24)/t16-,21?/m0/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 47n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164308
PNG
(US9669029, 48 2-[(E)-2-(4-Furan-3-yl-1-methyl-1H-i...)
Show SMILES COC1=CC=CN2N=C(NC12)\C=C/c1nc(cn1C)-c1ccoc1
Show InChI InChI=1S/C17H17N5O2/c1-21-10-13(12-7-9-24-11-12)18-16(21)6-5-15-19-17-14(23-2)4-3-8-22(17)20-15/h3-11,17H,1-2H3,(H,19,20)/b6-5-
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 47n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164355
PNG
(US9669029, 63 8-Fluoro-2-[2-(1-methyl-4-thiophen-2...)
Show SMILES Cn1cc(nc1CCC1=NN2C=CC=C(F)C2N1)-c1cccs1
Show InChI InChI=1S/C16H16FN5S/c1-21-10-12(13-5-3-9-23-13)18-15(21)7-6-14-19-16-11(17)4-2-8-22(16)20-14/h2-5,8-10,16H,6-7H2,1H3,(H,19,20)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 47n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164383
PNG
(US9669029, 86 5-Methyl-2-[2-(1-propyl-4-pyridin-3-...)
Show SMILES CCCn1cc(nc1CCC1=NN2C(N1)C=CC=C2C)-c1cccnc1
Show InChI InChI=1S/C20H24N6/c1-3-12-25-14-17(16-7-5-11-21-13-16)22-19(25)10-9-18-23-20-8-4-6-15(2)26(20)24-18/h4-8,11,13-14,20H,3,9-10,12H2,1-2H3,(H,23,24)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 49n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164368
PNG
(US9669029, 71 (S)-4-Methylamino-1-{2-[2-(5-methyl-...)
Show SMILES CNCC[C@H](O)Cn1cc(nc1CCC1=NN2C(N1)C=CC=C2C)-c1cccs1
Show InChI InChI=1S/C21H28N6OS/c1-15-5-3-7-21-24-19(25-27(15)21)8-9-20-23-17(18-6-4-12-29-18)14-26(20)13-16(28)10-11-22-2/h3-7,12,14,16,21-22,28H,8-11,13H2,1-2H3,(H,24,25)/t16-,21?/m0/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 51n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164295
PNG
(US9669029, 45 8-Methoxy-2-[(E)-2-(1-methyl-4-thiop...)
Show SMILES COC1=CC=CN2N=C(NC12)\C=C/c1nc(cn1C)-c1ccsc1
Show InChI InChI=1S/C17H17N5OS/c1-21-10-13(12-7-9-24-11-12)18-16(21)6-5-15-19-17-14(23-2)4-3-8-22(17)20-15/h3-11,17H,1-2H3,(H,19,20)/b6-5-
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 52n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164309
PNG
(US9669029, 49 8-Methoxy-2-{(E)-2-[1-methyl-4-(4-me...)
Show SMILES COC1=CC=CN2N=C(NC12)\C=C/c1nc(cn1C)-c1cscc1C
Show InChI InChI=1S/C18H19N5OS/c1-12-10-25-11-13(12)14-9-22(2)17(19-14)7-6-16-20-18-15(24-3)5-4-8-23(18)21-16/h4-11,18H,1-3H3,(H,20,21)/b7-6-
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM173089
PNG
(US9096589, 5,7-Dimethyl-2-[(E)-2-(1-methyl-4-thiop...)
Show SMILES Cc1cc(C)n2cc(\C=C\c3nc(cn3C)-c3ccsc3)nc2n1
Show InChI InChI=1S/C18H17N5S/c1-12-8-13(2)23-9-15(20-18(23)19-12)4-5-17-21-16(10-22(17)3)14-6-7-24-11-14/h4-11H,1-3H3/b5-4+
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 56n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164346
PNG
(US9669029, 56 8-Methoxy-2-{2-[1-methyl-4-(5-methyl...)
Show SMILES COC1=CC=CN2N=C(CCc3nc(cn3C)-c3ccc(C)o3)NC12
Show InChI InChI=1S/C18H21N5O2/c1-12-6-7-14(25-12)13-11-22(2)17(19-13)9-8-16-20-18-15(24-3)5-4-10-23(18)21-16/h4-7,10-11,18H,8-9H2,1-3H3,(H,20,21)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 56n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164359
PNG
(US9669029, 67 (S)-1-{2-[2-(5-Methyl-[1,2,4]triazol...)
Show SMILES CC1=CC=CC2NC(CCc3nc(cn3C[C@@H](O)CN3CCCC3)-c3cccs3)=NN12
Show InChI InChI=1S/C23H30N6OS/c1-17-6-4-8-23-25-21(26-29(17)23)9-10-22-24-19(20-7-5-13-31-20)16-28(22)15-18(30)14-27-11-2-3-12-27/h4-8,13,16,18,23,30H,2-3,9-12,14-15H2,1H3,(H,25,26)/t18-,23?/m0/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 58n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM173110
PNG
(US9096589, 1-{2-[2-(5,7-Dimethyl-imidazo[1,2-a]pyr...)
Show SMILES COCC(O)Cn1cc(nc1CCc1cn2c(C)cc(C)nc2n1)-c1cncs1
Show InChI InChI=1S/C20H24N6O2S/c1-13-6-14(2)26-8-15(23-20(26)22-13)4-5-19-24-17(18-7-21-12-29-18)10-25(19)9-16(27)11-28-3/h6-8,10,12,16,27H,4-5,9,11H2,1-3H3
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 58n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM173097
PNG
(US9096589, 2-{2-[1-(2-Fluoro-ethyl)-4-thiophen-2-y...)
Show SMILES Cc1cc(C)n2cc(CCc3nc(cn3CCF)-c3cccs3)nc2n1
Show InChI InChI=1S/C19H20FN5S/c1-13-10-14(2)25-11-15(22-19(25)21-13)5-6-18-23-16(12-24(18)8-7-20)17-4-3-9-26-17/h3-4,9-12H,5-8H2,1-2H3
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 62n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164376
PNG
(US9669029, 79 8-Methoxy-2-[2-(4-thiazol-5-yl-1H-im...)
Show SMILES COC1=CC=CN2N=C(CCc3ncc(n3)-c3cncs3)NC12
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 62n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164294
PNG
(US9669029, 44 8-Methoxy-2-[(E)-2-(1-methyl-4-thiop...)
Show SMILES COC1=CC=CN2N=C(NC12)\C=C/c1nc(cn1C)-c1cccs1
Show InChI InChI=1S/C17H17N5OS/c1-21-11-12(14-6-4-10-24-14)18-16(21)8-7-15-19-17-13(23-2)5-3-9-22(17)20-15/h3-11,17H,1-2H3,(H,19,20)/b8-7-
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 62n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164374
PNG
(US9669029, 77 8-Methyl-2-[2-(4-pyridin-3-yl-1H-imi...)
Show SMILES CC1=CC=CN2N=C(CCc3ncc(n3)-c3cccnc3)NC12
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 64n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164358
PNG
(US9669029, 66 (S)-1-Methylamino-3-{2-[2-(5-methyl-...)
Show SMILES CNC[C@H](O)Cn1cc(nc1CCC1=NN2C(N1)C=CC=C2C)-c1cccs1
Show InChI InChI=1S/C20H26N6OS/c1-14-5-3-7-20-23-18(24-26(14)20)8-9-19-22-16(17-6-4-10-28-17)13-25(19)12-15(27)11-21-2/h3-7,10,13,15,20-21,27H,8-9,11-12H2,1-2H3,(H,23,24)/t15-,20?/m0/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 70n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164384
PNG
(US9669029, 87 5-Methyl-2-[2-(1-methyl-4-pyridin-3-...)
Show SMILES CC1=CC=CC2NC(CCc3nc(cn3C)-c3cccnc3)=NN12
Show InChI InChI=1S/C18H20N6/c1-13-5-3-7-18-21-16(22-24(13)18)8-9-17-20-15(12-23(17)2)14-6-4-10-19-11-14/h3-7,10-12,18H,8-9H2,1-2H3,(H,21,22)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 71n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164385
PNG
(US9669029, 88 8-Methyl-2-[2-(1-methyl-4-pyridin-3-...)
Show SMILES CC1=CC=CN2N=C(CCc3nc(cn3C)-c3cccnc3)NC12
Show InChI InChI=1S/C18H20N6/c1-13-5-4-10-24-18(13)21-16(22-24)7-8-17-20-15(12-23(17)2)14-6-3-9-19-11-14/h3-6,9-12,18H,7-8H2,1-2H3,(H,21,22)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164367
PNG
(US9669029, 70 (S)-1-Diethylamino-3-{2-[2-(5-methyl...)
Show SMILES CCN(CC)C[C@H](O)Cn1cc(nc1CCC1=NN2C(N1)C=CC=C2C)-c1cccs1
Show InChI InChI=1S/C23H32N6OS/c1-4-27(5-2)14-18(30)15-28-16-19(20-9-7-13-31-20)24-22(28)12-11-21-25-23-10-6-8-17(3)29(23)26-21/h6-10,13,16,18,23,30H,4-5,11-12,14-15H2,1-3H3,(H,25,26)/t18-,23?/m0/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 77n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164265
PNG
(US9669029, 15 5,7-Dimethyl-2-{(E)-2-[4-thiophen-2-...)
Show SMILES Cc1cc(C)n2cc(\C=C\c3nc(cn3COCC[Si](C)(C)C)-c3-[s]ccc3)nc2n1
Show InChI InChI=1S/C23H29N5OSSi/c1-17-13-18(2)28-14-19(25-23(28)24-17)8-9-22-26-20(21-7-6-11-30-21)15-27(22)16-29-10-12-31(3,4)5/h6-9,11,13-15H,10,12,16H2,1-5H3/b9-8+
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 81n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164296
PNG
(US9669029, 46 8-Methoxy-2-[(E)-2-(1-methyl-4-thiaz...)
Show SMILES COC1=CC=CN2N=C(NC12)\C=C/c1nc(cn1C)-c1cncs1
Show InChI InChI=1S/C16H16N6OS/c1-21-9-11(13-8-17-10-24-13)18-15(21)6-5-14-19-16-12(23-2)4-3-7-22(16)20-14/h3-10,16H,1-2H3,(H,19,20)/b6-5-
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 85n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164356
PNG
(US9669029, 64 8-Fluoro-2-{2-[1-methyl-4-(5-methyl-...)
Show SMILES Cc1ccc(o1)-c1cn(C)c(CCC2=NN3C=CC=C(F)C3N2)n1
Show InChI InChI=1S/C17H18FN5O/c1-11-5-6-14(24-11)13-10-22(2)16(19-13)8-7-15-20-17-12(18)4-3-9-23(17)21-15/h3-6,9-10,17H,7-8H2,1-2H3,(H,20,21)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 94n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164373
PNG
(US9669029, 76 (S)-1-(Isopropyl-methyl-amino)-3-{2-...)
Show SMILES CC(C)N(C)C[C@H](O)Cn1cc(nc1CCC1=NN2C(N1)C=CC=C2C)-c1cccs1
Show InChI InChI=1S/C23H32N6OS/c1-16(2)27(4)13-18(30)14-28-15-19(20-8-6-12-31-20)24-22(28)11-10-21-25-23-9-5-7-17(3)29(23)26-21/h5-9,12,15-16,18,23,30H,10-11,13-14H2,1-4H3,(H,25,26)/t18-,23?/m0/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 97n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164258
PNG
(US9669029, 8 5,7-Dimethyl-2-[(E)-2-(1-methyl-4-thi...)
Show SMILES Cc1cc(C)n2cc(\C=C\c3nc(cn3C)-c3-[s]cnc3)nc2n1
Show InChI InChI=1S/C17H16N6S/c1-11-6-12(2)23-8-13(20-17(23)19-11)4-5-16-21-14(9-22(16)3)15-7-18-10-24-15/h4-10H,1-3H3/b5-4+
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 97n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164351
PNG
(US9669029, 60 8-Fluoro-2-[(E)-2-(1-methyl-4-thioph...)
Show SMILES Cn1cc(nc1\C=C/C1=NN2C=CC=C(F)C2N1)-c1cccs1
Show InChI InChI=1S/C16H14FN5S/c1-21-10-12(13-5-3-9-23-13)18-15(21)7-6-14-19-16-11(17)4-2-8-22(16)20-14/h2-10,16H,1H3,(H,19,20)/b7-6-
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 100n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164379
PNG
(US9669029, 82 8-Methoxy-2-{2-[4-(5-methyl-furan-2-...)
Show SMILES COC1=CC=CN2N=C(CCc3ncc(n3)-c3ccc(C)o3)NC12
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 120n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM173107
PNG
(US9096589, 2-{2-[1-(2-Methoxy-ethyl)-4-thiophen-2-...)
Show SMILES COCCn1cc(nc1CCc1cn2c(C)cc(C)nc2n1)-c1cccs1
Show InChI InChI=1S/C20H23N5OS/c1-14-11-15(2)25-12-16(22-20(25)21-14)6-7-19-23-17(18-5-4-10-27-18)13-24(19)8-9-26-3/h4-5,10-13H,6-9H2,1-3H3
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 130n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164264
PNG
(US9669029, 11 2-[(E)-2-(4-Furan-3-yl-1-methyl-1H-i...)
Show SMILES Cc1cc(C)n2cc(\C=C\c3nc(cn3C)C3COC=C3)nc2n1
Show InChI InChI=1S/C18H19N5O/c1-12-8-13(2)23-9-15(20-18(23)19-12)4-5-17-21-16(10-22(17)3)14-6-7-24-11-14/h4-10,14H,11H2,1-3H3/b5-4+
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 140n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164305
PNG
(US9669029, 47 8-Methoxy-2-{(E)-2-[1-methyl-4-(5-me...)
Show SMILES COC1=CC=CN2N=C(NC12)\C=C/c1nc(cn1C)-c1ccc(C)o1
Show InChI InChI=1S/C18H19N5O2/c1-12-6-7-14(25-12)13-11-22(2)17(19-13)9-8-16-20-18-15(24-3)5-4-10-23(18)21-16/h4-11,18H,1-3H3,(H,20,21)/b9-8-
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 140n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM173103
PNG
(US9096589, 2-[2-(1-Isopropyl-4-thiophen-2-yl-1H-im...)
Show SMILES CC(C)n1cc(nc1CCc1cn2c(C)cc(C)nc2n1)-c1cccs1
Show InChI InChI=1S/C20H23N5S/c1-13(2)24-12-17(18-6-5-9-26-18)23-19(24)8-7-16-11-25-15(4)10-14(3)21-20(25)22-16/h5-6,9-13H,7-8H2,1-4H3
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 160n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM173088
PNG
(US9096589, 5,7-Dimethyl-2-[(E)-2-(1-methyl-4-thiaz...)
Show SMILES Cc1cc(C)n2cc(\C=C\c3nc(cn3C)-c3cscn3)nc2n1
Show InChI InChI=1S/C17H16N6S/c1-11-6-12(2)23-7-13(20-17(23)19-11)4-5-16-21-14(8-22(16)3)15-9-24-10-18-15/h4-10H,1-3H3/b5-4+
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 180n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164287
PNG
(US9669029, 37 5-Methyl-2-{(E)-2-[4-(5-methyl-thiop...)
Show SMILES Cc1ccc(s1)-c1cn(COCC[Si](C)(C)C)c(\C=C/C2=NN3C(N2)C=CC=C3C)n1
Show InChI InChI=1S/C23H31N5OSSi/c1-17-7-6-8-23-25-21(26-28(17)23)11-12-22-24-19(20-10-9-18(2)30-20)15-27(22)16-29-13-14-31(3,4)5/h6-12,15,23H,13-14,16H2,1-5H3,(H,25,26)/b12-11-
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 210n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM173109
PNG
(US9096589, 2-{2-[1-(2-Methoxy-ethyl)-4-thiazol-5-y...)
Show SMILES COCCn1cc(nc1CCc1cn2c(C)cc(C)nc2n1)-c1cncs1
Show InChI InChI=1S/C19H22N6OS/c1-13-8-14(2)25-10-15(22-19(25)21-13)4-5-18-23-16(17-9-20-12-27-17)11-24(18)6-7-26-3/h8-12H,4-7H2,1-3H3
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 210n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164242
PNG
(US9669029, 2 5,7-Dimethyl-2-[(E)-2-(1-methyl-4-pyr...)
Show SMILES Cc1cc(C)n2cc(CCc3nc(cn3C)-c3ccnc3)nc2n1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 220n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164377
PNG
(US9669029, 80 8-Methoxy-2-[2-(4-pyridin-3-yl-1H-im...)
Show SMILES COC1=CC=CN2N=C(CCc3ncc(n3)-c3cccnc3)NC12
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 270n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164348
PNG
(US9669029, 58 8-Fluoro-2-[(E)-2-(1-methyl-4-thiazo...)
Show SMILES Cn1cc(nc1CCC1=NN2C=CC=C(F)C2N1)-c1cncs1
Show InChI InChI=1S/C15H15FN6S/c1-21-8-11(12-7-17-9-23-12)18-14(21)5-4-13-19-15-10(16)3-2-6-22(15)20-13/h2-3,6-9,15H,4-5H2,1H3,(H,19,20)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM173086
PNG
(US9096589, 5,7-Dimethyl-2-[(E)-2-(1-methyl-4-pyraz...)
Show SMILES Cc1cc(C)n2cc(\C=C\c3nc(cn3C)-c3cnccn3)nc2n1
Show InChI InChI=1S/C18H17N7/c1-12-8-13(2)25-10-14(22-18(25)21-12)4-5-17-23-16(11-24(17)3)15-9-19-6-7-20-15/h4-11H,1-3H3/b5-4+
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 340n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164353
PNG
(US9669029, 61 8-Fluoro-2-{(E)-2-[1-methyl-4-(5-met...)
Show SMILES Cc1ccc(o1)-c1cn(C)c(\C=C/C2=NN3C=CC=C(F)C3N2)n1
Show InChI InChI=1S/C17H16FN5O/c1-11-5-6-14(24-11)13-10-22(2)16(19-13)8-7-15-20-17-12(18)4-3-9-23(17)21-15/h3-10,17H,1-2H3,(H,20,21)/b8-7-
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 520n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
PED10A


(Homo sapiens (human))
BDBM164370
PNG
(US9669029, 73 3-[((S)-2-Hydroxy-3-{2-[2-(5-methyl-...)
Show SMILES CN(CCC#N)C[C@H](O)Cn1cc(nc1CCC1=NN2C(N1)C=CC=C2C)-c1cccs1
Show InChI InChI=1S/C23H29N7OS/c1-17-6-3-8-23-26-21(27-30(17)23)9-10-22-25-19(20-7-4-13-32-20)16-29(22)15-18(31)14-28(2)12-5-11-24/h3-4,6-8,13,16,18,23,31H,5,9-10,12,14-15H2,1-2H3,(H,26,27)/t18-,23?/m0/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.00E+4n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%