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Patent code US9669095

Compile Data Set for Download or QSAR
Found 13 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM179947
PNG
(US9669095, 7)
Show SMILES CC[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@@H](N(C)C(=O)[C@@H](C)N(C)C1=O)C(C)(C)CN(C)C(=O)OC)C(C)C)C(=O)[C@H](C)CCCCCSc1nnnn1C
Show InChI InChI=1S/C68H120N16O14S/c1-27-46-62(93)78(19)45(15)61(92)83(24)54(68(16,17)36-77(18)67(97)98-26)59(90)72-50(40(8)9)65(96)79(20)47(33-37(2)3)56(87)69-43(13)55(86)70-44(14)60(91)80(21)48(34-38(4)5)63(94)81(22)49(35-39(6)7)64(95)82(23)52(41(10)11)58(89)73-51(57(88)71-46)53(85)42(12)31-29-28-30-32-99-66-74-75-76-84(66)25/h37-52,54H,27-36H2,1-26H3,(H,69,87)(H,70,86)(H,71,88)(H,72,90)(H,73,89)/t42-,43+,44-,45-,46+,47+,48+,49+,50+,51+,52+,54-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
Briefly, replicon cells are seeded at 7,000 cells per well in 90 ul DMEM (without phenol red, Invitrogen Cat. #31053-036) per well with 10% FCS, 1% n...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM179949
PNG
(US9669095, 8)
Show SMILES CC[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@@H](N(C)C(=O)[C@@H](C)N(C)C1=O)C(C)(C)CN(C)C(=O)[C@@H](NC(=O)OC)C(C)C)C(C)C)C(=O)[C@H](C)CCCCCN1CCOCC1
Show InChI InChI=1S/C75H134N14O16/c1-28-52-69(98)83(21)51(17)68(97)88(26)61(75(18,19)41-82(20)72(101)56(45(8)9)81-74(103)104-27)66(95)79-57(46(10)11)73(102)84(22)53(38-42(2)3)63(92)76-49(15)62(91)77-50(16)67(96)85(23)54(39-43(4)5)70(99)86(24)55(40-44(6)7)71(100)87(25)59(47(12)13)65(94)80-58(64(93)78-52)60(90)48(14)32-30-29-31-33-89-34-36-105-37-35-89/h42-59,61H,28-41H2,1-27H3,(H,76,92)(H,77,91)(H,78,93)(H,79,95)(H,80,94)(H,81,103)/t48-,49+,50-,51-,52+,53+,54+,55+,56+,57+,58+,59+,61-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
Briefly, replicon cells are seeded at 7,000 cells per well in 90 ul DMEM (without phenol red, Invitrogen Cat. #31053-036) per well with 10% FCS, 1% n...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM179850
PNG
(US9669095, 2)
Show SMILES CCCC[C@@H](C)C(=O)[C@@H]1NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@@H](N(C)C(=O)[C@@H](C)N(C)C(=O)[C@H](CC)NC1=O)C(C)(C)CO)C(C)C
Show InChI InChI=1S/C62H111N11O13/c1-25-27-28-38(13)49(75)47-53(78)65-42(26-2)58(83)68(19)41(16)57(82)73(24)50(62(17,18)32-74)55(80)66-46(36(9)10)61(86)69(20)43(29-33(3)4)52(77)63-39(14)51(76)64-40(15)56(81)70(21)44(30-34(5)6)59(84)71(22)45(31-35(7)8)60(85)72(23)48(37(11)12)54(79)67-47/h33-48,50,74H,25-32H2,1-24H3,(H,63,77)(H,64,76)(H,65,78)(H,66,80)(H,67,79)/t38-,39+,40-,41-,42+,43+,44+,45+,46+,47+,48+,50-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
Briefly, replicon cells are seeded at 7,000 cells per well in 90 ul DMEM (without phenol red, Invitrogen Cat. #31053-036) per well with 10% FCS, 1% n...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM179974
PNG
(US9669095, 11)
Show SMILES CC[C@@H]1NC(=O)[C@@H]2C(ON2C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@@H](N(C)C(=O)[C@@H](C)N(C)C1=O)C(C)(C)COC(=O)NS(C)(=O)=O)C(C)C)[C@H](C)C\C=C\C
Show InChI InChI=1S/C64H112N12O16S/c1-26-28-29-39(13)50-49-54(79)67-43(27-2)58(83)70(19)42(16)57(82)75(24)51(64(17,18)33-91-63(88)69-93(25,89)90)55(80)68-47(37(9)10)61(86)71(20)44(30-34(3)4)53(78)65-40(14)52(77)66-41(15)56(81)72(21)45(31-35(5)6)59(84)73(22)46(32-36(7)8)60(85)74(23)48(38(11)12)62(87)76(49)92-50/h26,28,34-51H,27,29-33H2,1-25H3,(H,65,78)(H,66,77)(H,67,79)(H,68,80)(H,69,88)/b28-26+/t39-,40+,41-,42-,43+,44+,45-,46+,47+,48+,49+,50?,51-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+3n/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
Briefly, replicon cells are seeded at 7,000 cells per well in 90 ul DMEM (without phenol red, Invitrogen Cat. #31053-036) per well with 10% FCS, 1% n...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM179849
PNG
(US9669095, 1)
Show SMILES CC[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@@H](N(C)C(=O)[C@@H](C)N(C)C1=O)C(C)(C)CNC)C(C)C)C(=O)[C@H](C)C\C=C\C
Show InChI InChI=1S/C63H112N12O12/c1-26-28-29-39(13)50(76)48-54(79)67-43(27-2)59(84)70(20)42(16)58(83)75(25)51(63(17,18)33-64-19)56(81)68-47(37(9)10)62(87)71(21)44(30-34(3)4)53(78)65-40(14)52(77)66-41(15)57(82)72(22)45(31-35(5)6)60(85)73(23)46(32-36(7)8)61(86)74(24)49(38(11)12)55(80)69-48/h26,28,34-49,51,64H,27,29-33H2,1-25H3,(H,65,78)(H,66,77)(H,67,79)(H,68,81)(H,69,80)/b28-26+/t39-,40+,41-,42-,43+,44+,45+,46+,47+,48+,49+,51-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
Briefly, replicon cells are seeded at 7,000 cells per well in 90 ul DMEM (without phenol red, Invitrogen Cat. #31053-036) per well with 10% FCS, 1% n...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM179852
PNG
(US9669095, 4)
Show SMILES CCCC[C@@H](C)C(=O)[C@@H]1NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@@H](N(C)C(=O)[C@@H](C)N(C)C(=O)[C@H](CC)NC1=O)C(C)(C)COC(=O)N(C)C)C(C)C
Show InChI InChI=1S/C65H116N12O14/c1-27-29-30-40(13)51(78)49-55(81)68-44(28-2)60(86)72(21)43(16)59(85)77(26)52(65(17,18)34-91-64(90)71(19)20)57(83)69-48(38(9)10)63(89)73(22)45(31-35(3)4)54(80)66-41(14)53(79)67-42(15)58(84)74(23)46(32-36(5)6)61(87)75(24)47(33-37(7)8)62(88)76(25)50(39(11)12)56(82)70-49/h35-50,52H,27-34H2,1-26H3,(H,66,80)(H,67,79)(H,68,81)(H,69,83)(H,70,82)/t40-,41+,42-,43-,44+,45+,46+,47+,48+,49+,50+,52-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
Briefly, replicon cells are seeded at 7,000 cells per well in 90 ul DMEM (without phenol red, Invitrogen Cat. #31053-036) per well with 10% FCS, 1% n...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM179979
PNG
(US9669095, 13)
Show SMILES CC[C@@H]1NC(=O)[C@@H]2C(ON2C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@@H](N(C)C(=O)[C@@H](C)N(C)C1=O)C(C)(C)CN(C)C(=O)NS(C)(=O)=O)C(C)C)[C@H](C)C\C=C\C
Show InChI InChI=1S/C65H115N13O15S/c1-27-29-30-40(13)51-50-55(81)68-44(28-2)59(85)72(20)43(16)58(84)77(25)52(65(17,18)34-71(19)64(90)70-94(26,91)92)56(82)69-48(38(9)10)62(88)73(21)45(31-35(3)4)54(80)66-41(14)53(79)67-42(15)57(83)74(22)46(32-36(5)6)60(86)75(23)47(33-37(7)8)61(87)76(24)49(39(11)12)63(89)78(50)93-51/h27,29,35-52H,28,30-34H2,1-26H3,(H,66,80)(H,67,79)(H,68,81)(H,69,82)(H,70,90)/b29-27+/t40-,41+,42-,43-,44+,45+,46-,47+,48+,49+,50+,51?,52-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 550n/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
Briefly, replicon cells are seeded at 7,000 cells per well in 90 ul DMEM (without phenol red, Invitrogen Cat. #31053-036) per well with 10% FCS, 1% n...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM182860
PNG
(US9669095, 14)
Show SMILES CC[C@@H]1NC(=O)[C@@H]2C(ON2C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@@H](N(C)C(=O)[C@@H](C)N(C)C1=O)C(C)(C)CN(C)C(=O)NS(=O)(=O)c1ccccc1)C(C)C)[C@H](C)C\C=C\C
Show InChI InChI=1S/C70H117N13O15S/c1-26-28-32-44(13)56-55-60(86)73-49(27-2)64(90)77(20)47(16)63(89)82(25)57(70(17,18)38-76(19)69(95)75-99(96,97)48-33-30-29-31-34-48)61(87)74-53(42(9)10)67(93)78(21)50(35-39(3)4)59(85)71-45(14)58(84)72-46(15)62(88)79(22)51(36-40(5)6)65(91)80(23)52(37-41(7)8)66(92)81(24)54(43(11)12)68(94)83(55)98-56/h26,28-31,33-34,39-47,49-57H,27,32,35-38H2,1-25H3,(H,71,85)(H,72,84)(H,73,86)(H,74,87)(H,75,95)/b28-26+/t44-,45+,46-,47-,49+,50+,51-,52+,53+,54+,55+,56?,57-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 550n/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
Briefly, replicon cells are seeded at 7,000 cells per well in 90 ul DMEM (without phenol red, Invitrogen Cat. #31053-036) per well with 10% FCS, 1% n...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM179851
PNG
(US9669095, 3)
Show SMILES CCCC[C@@H](C)C(=O)[C@@H]1NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@@H](N(C)C(=O)[C@@H](C)N(C)C(=O)[C@H](CC)NC1=O)C(C)(C)COC(=O)NC)C(C)C
Show InChI InChI=1S/C64H114N12O14/c1-26-28-29-39(13)50(77)48-54(80)68-43(27-2)59(85)71(20)42(16)58(84)76(25)51(64(17,18)33-90-63(89)65-19)56(82)69-47(37(9)10)62(88)72(21)44(30-34(3)4)53(79)66-40(14)52(78)67-41(15)57(83)73(22)45(31-35(5)6)60(86)74(23)46(32-36(7)8)61(87)75(24)49(38(11)12)55(81)70-48/h34-49,51H,26-33H2,1-25H3,(H,65,89)(H,66,79)(H,67,78)(H,68,80)(H,69,82)(H,70,81)/t39-,40+,41-,42-,43+,44+,45+,46+,47+,48+,49+,51-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
Briefly, replicon cells are seeded at 7,000 cells per well in 90 ul DMEM (without phenol red, Invitrogen Cat. #31053-036) per well with 10% FCS, 1% n...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM179857
PNG
(US9669095, 5)
Show SMILES CC[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@@H](N(C)C(=O)[C@@H](C)N(C)C1=O)C(C)(C)COC(=O)NC)C(C)C)C(=O)[C@H](C)C\C=C\C
Show InChI InChI=1S/C64H112N12O14/c1-26-28-29-39(13)50(77)48-54(80)68-43(27-2)59(85)71(20)42(16)58(84)76(25)51(64(17,18)33-90-63(89)65-19)56(82)69-47(37(9)10)62(88)72(21)44(30-34(3)4)53(79)66-40(14)52(78)67-41(15)57(83)73(22)45(31-35(5)6)60(86)74(23)46(32-36(7)8)61(87)75(24)49(38(11)12)55(81)70-48/h26,28,34-49,51H,27,29-33H2,1-25H3,(H,65,89)(H,66,79)(H,67,78)(H,68,80)(H,69,82)(H,70,81)/b28-26+/t39-,40+,41-,42-,43+,44+,45+,46+,47+,48+,49+,51-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
Briefly, replicon cells are seeded at 7,000 cells per well in 90 ul DMEM (without phenol red, Invitrogen Cat. #31053-036) per well with 10% FCS, 1% n...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM179858
PNG
(US9669095, 6)
Show SMILES CC[C@@H]1NC(=O)[C@@H](NC(=O)[C@@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@@H](N(C)C(=O)[C@@H](C)N(C)C1=O)C(C)(C)CN(C)C(=O)OC)C(C)C)C(=O)[C@H](C)CCCCCN1CCOCC1
Show InChI InChI=1S/C70H125N13O15/c1-26-49-65(92)77(19)48(15)64(91)82(24)57(70(16,17)39-76(18)69(96)97-25)62(89)74-53(43(8)9)68(95)78(20)50(36-40(2)3)59(86)71-46(13)58(85)72-47(14)63(90)79(21)51(37-41(4)5)66(93)80(22)52(38-42(6)7)67(94)81(23)55(44(10)11)61(88)75-54(60(87)73-49)56(84)45(12)30-28-27-29-31-83-32-34-98-35-33-83/h40-55,57H,26-39H2,1-25H3,(H,71,86)(H,72,85)(H,73,87)(H,74,89)(H,75,88)/t45-,46+,47-,48-,49+,50-,51+,52+,53+,54+,55-,57-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
Briefly, replicon cells are seeded at 7,000 cells per well in 90 ul DMEM (without phenol red, Invitrogen Cat. #31053-036) per well with 10% FCS, 1% n...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM179975
PNG
(US9669095, 12)
Show SMILES CC[C@@H]1NC(=O)[C@@H]2C(ON2C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@@H](N(C)C(=O)[C@@H](C)N(C)C1=O)C(C)(C)COC(=O)NS(=O)(=O)c1ccccc1)C(C)C)[C@H](C)C\C=C\C
Show InChI InChI=1S/C69H114N12O16S/c1-25-27-31-43(13)55-54-59(84)72-48(26-2)63(88)75(19)46(16)62(87)80(24)56(69(17,18)37-96-68(93)74-98(94,95)47-32-29-28-30-33-47)60(85)73-52(41(9)10)66(91)76(20)49(34-38(3)4)58(83)70-44(14)57(82)71-45(15)61(86)77(21)50(35-39(5)6)64(89)78(22)51(36-40(7)8)65(90)79(23)53(42(11)12)67(92)81(54)97-55/h25,27-30,32-33,38-46,48-56H,26,31,34-37H2,1-24H3,(H,70,83)(H,71,82)(H,72,84)(H,73,85)(H,74,93)/b27-25+/t43-,44+,45-,46-,48+,49+,50-,51+,52+,53+,54+,55?,56-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 550n/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
Briefly, replicon cells are seeded at 7,000 cells per well in 90 ul DMEM (without phenol red, Invitrogen Cat. #31053-036) per well with 10% FCS, 1% n...


Citation and Details
More data for this
Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase


(Hepatitis C virus (HCV genotype 1a, isolate H))
BDBM179969
PNG
(US9669095, 9)
Show SMILES CC[C@@H]1NC(=O)[C@@H](NC(=O)[C@@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@@H](N(C)C(=O)[C@@H](C)N(C)C1=O)C(C)(C)CN(C)C(=O)[C@@H](NC(=O)OC)C(C)C)C(C)C)C(=O)[C@H](C)CCCCCSc1nnnn1C
Show InChI InChI=1S/C73H129N17O15S/c1-29-49-66(99)84(21)48(17)65(98)89(26)58(73(18,19)38-83(20)69(102)53(42(8)9)79-72(104)105-28)63(96)77-54(43(10)11)70(103)85(22)50(35-39(2)3)60(93)74-46(15)59(92)75-47(16)64(97)86(23)51(36-40(4)5)67(100)87(24)52(37-41(6)7)68(101)88(25)56(44(12)13)62(95)78-55(61(94)76-49)57(91)45(14)33-31-30-32-34-106-71-80-81-82-90(71)27/h39-56,58H,29-38H2,1-28H3,(H,74,93)(H,75,92)(H,76,94)(H,77,96)(H,78,95)(H,79,104)/t45-,46+,47-,48-,49+,50-,51+,52+,53+,54+,55+,56-,58-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
Briefly, replicon cells are seeded at 7,000 cells per well in 90 ul DMEM (without phenol red, Invitrogen Cat. #31053-036) per well with 10% FCS, 1% n...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%