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Patent code US9670142

Compile Data Set for Download or QSAR
Found 171 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM182944
PNG
(US9670142, A6 4-benzothiazol-2-yl-N-methyl-N-((1R,...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1nc2ccccc2s1
Show InChI InChI=1S/C23H25N3O2S/c1-3-21(27)24-17-12-13-18(14-17)26(2)23(28)16-10-8-15(9-11-16)22-25-19-6-4-5-7-20(19)29-22/h4-11,17-18H,3,12-14H2,1-2H3,(H,24,27)/t17-,18+/m0/s1
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n/an/a<300n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM182952
PNG
(US9670142, A14 4-(4-chloro-phenylethynyl)-N-methyl...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)C#Cc1ccc(Cl)cc1
Show InChI InChI=1S/C24H25ClN2O2/c1-3-23(28)26-21-14-15-22(16-21)27(2)24(29)19-10-6-17(7-11-19)4-5-18-8-12-20(25)13-9-18/h6-13,21-22H,3,14-16H2,1-2H3,(H,26,28)/t21-,22+/m0/s1
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Merck Patent GmbH

US Patent


Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183639
PNG
(US9670142, A88 2',4'-dimethoxy-biphenyl-4-...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(OC)cc1OC
Show InChI InChI=1S/C24H30N2O4/c1-5-23(27)25-18-10-11-19(14-18)26(2)24(28)17-8-6-16(7-9-17)21-13-12-20(29-3)15-22(21)30-4/h6-9,12-13,15,18-19H,5,10-11,14H2,1-4H3,(H,25,27)/t18-,19+/m0/s1
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Merck Patent GmbH

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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM184585
PNG
(US9670142, A115 N-methyl-4-(3-methyl-1H-indol-5-yl...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc2[nH]cc(C)c2c1
Show InChI InChI=1S/C25H29N3O2/c1-4-24(29)27-20-10-11-21(14-20)28(3)25(30)18-7-5-17(6-8-18)19-9-12-23-22(13-19)16(2)15-26-23/h5-9,12-13,15,20-21,26H,4,10-11,14H2,1-3H3,(H,27,29)/t20-,21+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM185518
PNG
(US9670142, A122 4-(6-fluoro-1H-indol-5-yl)-N-methy...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1cc2cc[nH]c2cc1F
Show InChI InChI=1S/C24H26FN3O2/c1-3-23(29)27-18-8-9-19(13-18)28(2)24(30)16-6-4-15(5-7-16)20-12-17-10-11-26-22(17)14-21(20)25/h4-7,10-12,14,18-19,26H,3,8-9,13H2,1-2H3,(H,27,29)/t18-,19+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM185555
PNG
(US9670142, A128 4-(6-chloro-benzoxazol-2-yl)-N-met...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1nc2ccc(Cl)cc2o1
Show InChI InChI=1S/C23H24ClN3O3/c1-3-21(28)25-17-9-10-18(13-17)27(2)23(29)15-6-4-14(5-7-15)22-26-19-11-8-16(24)12-20(19)30-22/h4-8,11-12,17-18H,3,9-10,13H2,1-2H3,(H,25,28)/t17-,18+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM185561
PNG
(US9670142, A129 N-methyl-N-((1R,3S)-3-propionylami...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc2[nH]ccc2n1
Show InChI InChI=1S/C23H26N4O2/c1-3-22(28)25-17-8-9-18(14-17)27(2)23(29)16-6-4-15(5-7-16)19-10-11-20-21(26-19)12-13-24-20/h4-7,10-13,17-18,24H,3,8-9,14H2,1-2H3,(H,25,28)/t17-,18+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186319
PNG
(US9670142, A159 5-(6-chloro-benzoxazol-2-yl)-pyraz...)
Show SMILES CN([C@@H]1CC[C@@H](C1)NC(=O)[C@@H]1CCCO1)C(=O)c1cnc(cn1)-c1nc2ccc(Cl)cc2o1
Show InChI InChI=1S/C23H24ClN5O4/c1-29(15-6-5-14(10-15)27-21(30)19-3-2-8-32-19)23(31)18-12-25-17(11-26-18)22-28-16-7-4-13(24)9-20(16)33-22/h4,7,9,11-12,14-15,19H,2-3,5-6,8,10H2,1H3,(H,27,30)/t14-,15+,19-/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186796
PNG
(US9670142, A173 2-(1H-indol-5-yl)-4-methyl-thiazol...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1sc(nc1C)-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C22H26N4O2S/c1-4-19(27)25-16-6-7-17(12-16)26(3)22(28)20-13(2)24-21(29-20)15-5-8-18-14(11-15)9-10-23-18/h5,8-11,16-17,23H,4,6-7,12H2,1-3H3,(H,25,27)/t16-,17+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM182993
PNG
(US9670142, A30 4-benzoxazol-2-yl-N-methyl-N-[(1R,3...)
Show SMILES CC[C@H](C)CC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C26H31N3O3/c1-4-17(2)15-24(30)27-20-13-14-21(16-20)29(3)26(31)19-11-9-18(10-12-19)25-28-22-7-5-6-8-23(22)32-25/h5-12,17,20-21H,4,13-16H2,1-3H3,(H,27,30)/t17-,20-,21+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183409
PNG
(US9670142, A40 (R)-tetrahydro-furan-2-carboxylic a...)
Show SMILES CN([C@@H]1CC[C@@H](C1)NC(=O)[C@H]1CCCO1)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C25H27N3O4/c1-28(19-13-12-18(15-19)26-23(29)22-7-4-14-31-22)25(30)17-10-8-16(9-11-17)24-27-20-5-2-3-6-21(20)32-24/h2-3,5-6,8-11,18-19,22H,4,7,12-15H2,1H3,(H,26,29)/t18-,19+,22+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183472
PNG
(US9670142, A53 4'-fluoro-biphenyl-4-carboxylic...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H25FN2O2/c1-3-21(26)24-19-12-13-20(14-19)25(2)22(27)17-6-4-15(5-7-17)16-8-10-18(23)11-9-16/h4-11,19-20H,3,12-14H2,1-2H3,(H,24,26)/t19-,20+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183523
PNG
(US9670142, A63 3'-chloro-4'-fluoro-bipheny...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C22H24ClFN2O2/c1-3-21(27)25-17-9-10-18(13-17)26(2)22(28)15-6-4-14(5-7-15)16-8-11-20(24)19(23)12-16/h4-8,11-12,17-18H,3,9-10,13H2,1-2H3,(H,25,27)/t17-,18+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183557
PNG
(US9670142, A69 3-fluoro-4'-[methyl-((1R,3S)-3-...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(C(=O)OC)c(F)c1
Show InChI InChI=1S/C24H27FN2O4/c1-4-22(28)26-18-10-11-19(14-18)27(2)23(29)16-7-5-15(6-8-16)17-9-12-20(21(25)13-17)24(30)31-3/h5-9,12-13,18-19H,4,10-11,14H2,1-3H3,(H,26,28)/t18-,19+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183572
PNG
(US9670142, A72 N-methyl-N-((1R,3S)-3-propionylamin...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1cnc2ccccc2c1
Show InChI InChI=1S/C25H27N3O2/c1-3-24(29)27-21-12-13-22(15-21)28(2)25(30)18-10-8-17(9-11-18)20-14-19-6-4-5-7-23(19)26-16-20/h4-11,14,16,21-22H,3,12-13,15H2,1-2H3,(H,27,29)/t21-,22+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183575
PNG
(US9670142, A73 4'-methyl-biphenyl-4-carboxylic...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(C)cc1
Show InChI InChI=1S/C23H28N2O2/c1-4-22(26)24-20-13-14-21(15-20)25(3)23(27)19-11-9-18(10-12-19)17-7-5-16(2)6-8-17/h5-12,20-21H,4,13-15H2,1-3H3,(H,24,26)/t20-,21+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183633
PNG
(US9670142, A86 4'-chloro-3'-fluoro-bipheny...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C22H24ClFN2O2/c1-3-21(27)25-17-9-10-18(13-17)26(2)22(28)15-6-4-14(5-7-15)16-8-11-19(23)20(24)12-16/h4-8,11-12,17-18H,3,9-10,13H2,1-2H3,(H,25,27)/t17-,18+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM182964
PNG
(US9670142, A26 4-benzoxazol-2-yl-N-methyl-N-[(1R,3...)
Show SMILES CCC(C)CC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C26H31N3O3/c1-4-17(2)15-24(30)27-20-13-14-21(16-20)29(3)26(31)19-11-9-18(10-12-19)25-28-22-7-5-6-8-23(22)32-25/h5-12,17,20-21H,4,13-16H2,1-3H3,(H,27,30)/t17?,20-,21+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186094
PNG
(US9670142, A143 5-fluoro-6-(4-fluoro-1H-indol-5-yl...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1cnc(c(F)c1)-c1ccc2[nH]ccc2c1F
Show InChI InChI=1S/C23H24F2N4O2/c1-3-20(30)28-14-4-5-15(11-14)29(2)23(31)13-10-18(24)22(27-12-13)17-6-7-19-16(21(17)25)8-9-26-19/h6-10,12,14-15,26H,3-5,11H2,1-2H3,(H,28,30)/t14-,15+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183410
PNG
(US9670142, A41 (S)-tetrahydro-furan-2-carboxylic a...)
Show SMILES CN([C@@H]1CC[C@@H](C1)NC(=O)[C@@H]1CCCO1)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C25H27N3O4/c1-28(19-13-12-18(15-19)26-23(29)22-7-4-14-31-22)25(30)17-10-8-16(9-11-17)24-27-20-5-2-3-6-21(20)32-24/h2-3,5-6,8-11,18-19,22H,4,7,12-15H2,1H3,(H,26,29)/t18-,19+,22-/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183549
PNG
(US9670142, A68 4'-pyrazol-1-yl-biphenyl-4-carb...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(cc1)-n1cccn1
Show InChI InChI=1S/C25H28N4O2/c1-3-24(30)27-21-11-14-23(17-21)28(2)25(31)20-7-5-18(6-8-20)19-9-12-22(13-10-19)29-16-4-15-26-29/h4-10,12-13,15-16,21,23H,3,11,14,17H2,1-2H3,(H,27,30)/t21-,23+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183561
PNG
(US9670142, A71 4'-cyano-3'-fluoro-biphenyl...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C23H24FN3O2/c1-3-22(28)26-19-10-11-20(13-19)27(2)23(29)16-6-4-15(5-7-16)17-8-9-18(14-25)21(24)12-17/h4-9,12,19-20H,3,10-11,13H2,1-2H3,(H,26,28)/t19-,20+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183578
PNG
(US9670142, A75 N-methyl-4-(1-methyl-1H-indazol-5-y...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc2n(C)ncc2c1
Show InChI InChI=1S/C24H28N4O2/c1-4-23(29)26-20-10-11-21(14-20)27(2)24(30)17-7-5-16(6-8-17)18-9-12-22-19(13-18)15-25-28(22)3/h5-9,12-13,15,20-21H,4,10-11,14H2,1-3H3,(H,26,29)/t20-,21+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183588
PNG
(US9670142, A76 4-(1H-benzimidazol-5-yl)-N-methyl-N...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C23H26N4O2/c1-3-22(28)26-18-9-10-19(13-18)27(2)23(29)16-6-4-15(5-7-16)17-8-11-20-21(12-17)25-14-24-20/h4-8,11-12,14,18-19H,3,9-10,13H2,1-2H3,(H,24,25)(H,26,28)/t18-,19+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183624
PNG
(US9670142, A81 4'-(2H-pyrazol-3-yl)-biphenyl-4...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(cc1)-c1ccn[nH]1
Show InChI InChI=1S/C25H28N4O2/c1-3-24(30)27-21-12-13-22(16-21)29(2)25(31)20-10-6-18(7-11-20)17-4-8-19(9-5-17)23-14-15-26-28-23/h4-11,14-15,21-22H,3,12-13,16H2,1-2H3,(H,26,28)(H,27,30)/t21-,22+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183628
PNG
(US9670142, A84 4-(1H-indazol-5-yl)-N-methyl-N-((1R...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C23H26N4O2/c1-3-22(28)25-19-9-10-20(13-19)27(2)23(29)16-6-4-15(5-7-16)17-8-11-21-18(12-17)14-24-26-21/h4-8,11-12,14,19-20H,3,9-10,13H2,1-2H3,(H,24,26)(H,25,28)/t19-,20+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM182965
PNG
(US9670142, A27 4-benzoxazol-2-yl-N-[(1R,3S)-3-(2,2...)
Show SMILES CCC(F)(F)C(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C24H25F2N3O3/c1-3-24(25,26)23(31)27-17-12-13-18(14-17)29(2)22(30)16-10-8-15(9-11-16)21-28-19-6-4-5-7-20(19)32-21/h4-11,17-18H,3,12-14H2,1-2H3,(H,27,31)/t17-,18+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM182951
PNG
(US9670142, A13 4-benzoxazol-2-yl-3-methoxy-N-methy...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(-c2nc3ccccc3o2)c(OC)c1
Show InChI InChI=1S/C24H27N3O4/c1-4-22(28)25-16-10-11-17(14-16)27(2)24(29)15-9-12-18(21(13-15)30-3)23-26-19-7-5-6-8-20(19)31-23/h5-9,12-13,16-17H,4,10-11,14H2,1-3H3,(H,25,28)/t16-,17+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM182954
PNG
(US9670142, A16 5-benzoxazol-2-yl-pyridine-2-carbox...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cn1)-c1nc2ccccc2o1
Show InChI InChI=1S/C22H24N4O3/c1-3-20(27)24-15-9-10-16(12-15)26(2)22(28)18-11-8-14(13-23-18)21-25-17-6-4-5-7-19(17)29-21/h4-8,11,13,15-16H,3,9-10,12H2,1-2H3,(H,24,27)/t15-,16+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM184409
PNG
(US9670142, A94 N-methyl-4-(2-oxo-2,3-dihydro-1H-in...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc2NC(=O)Cc2c1
Show InChI InChI=1S/C24H27N3O3/c1-3-22(28)25-19-9-10-20(14-19)27(2)24(30)16-6-4-15(5-7-16)17-8-11-21-18(12-17)13-23(29)26-21/h4-8,11-12,19-20H,3,9-10,13-14H2,1-2H3,(H,25,28)(H,26,29)/t19-,20+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM184539
PNG
(US9670142, A109 5-(1H-indol-5-yl)-pyridine-2-carbo...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cn1)-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C23H26N4O2/c1-3-22(28)26-18-6-7-19(13-18)27(2)23(29)21-9-5-17(14-25-21)15-4-8-20-16(12-15)10-11-24-20/h4-5,8-12,14,18-19,24H,3,6-7,13H2,1-2H3,(H,26,28)/t18-,19+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM184615
PNG
(US9670142, A116 4-(4-fluoro-1H-indol-5-yl)-N-methy...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc2[nH]ccc2c1F
Show InChI InChI=1S/C24H26FN3O2/c1-3-22(29)27-17-8-9-18(14-17)28(2)24(30)16-6-4-15(5-7-16)19-10-11-21-20(23(19)25)12-13-26-21/h4-7,10-13,17-18,26H,3,8-9,14H2,1-2H3,(H,27,29)/t17-,18+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM185562
PNG
(US9670142, A130 4-(3-aminomethyl-1H-indol-5-yl)-N-...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc2[nH]cc(CN)c2c1
Show InChI InChI=1S/C25H30N4O2/c1-3-24(30)28-20-9-10-21(13-20)29(2)25(31)17-6-4-16(5-7-17)18-8-11-23-22(12-18)19(14-26)15-27-23/h4-8,11-12,15,20-21,27H,3,9-10,13-14,26H2,1-2H3,(H,28,30)/t20-,21+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186095
PNG
(US9670142, A144 6-imidazo[1,2-a]pyridin-6-yl-N-met...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(nc1)-c1ccc2nccn2c1
Show InChI InChI=1S/C22H25N5O2/c1-3-21(28)25-17-6-7-18(12-17)26(2)22(29)15-4-8-19(24-13-15)16-5-9-20-23-10-11-27(20)14-16/h4-5,8-11,13-14,17-18H,3,6-7,12H2,1-2H3,(H,25,28)/t17-,18+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186309
PNG
(US9670142, A150 6-(4-methyl-1H-indol-5-yl)-pyridaz...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(nn1)-c1ccc2[nH]ccc2c1C
Show InChI InChI=1S/C23H27N5O2/c1-4-22(29)25-15-5-6-16(13-15)28(3)23(30)21-10-9-20(26-27-21)17-7-8-19-18(14(17)2)11-12-24-19/h7-12,15-16,24H,4-6,13H2,1-3H3,(H,25,29)/t15-,16+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186708
PNG
(US9670142, A170 2-(1H-indol-5-yl)-thiazole-5-carbo...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1cnc(s1)-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C21H24N4O2S/c1-3-19(26)24-15-5-6-16(11-15)25(2)21(27)18-12-23-20(28-18)14-4-7-17-13(10-14)8-9-22-17/h4,7-10,12,15-16,22H,3,5-6,11H2,1-2H3,(H,24,26)/t15-,16+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183065
PNG
(US9670142, A37 4-benzoxazol-2-yl-N-[(1R,3S)-3-((S)...)
Show SMILES C[C@H](O)C(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C23H25N3O4/c1-14(27)21(28)24-17-11-12-18(13-17)26(2)23(29)16-9-7-15(8-10-16)22-25-19-5-3-4-6-20(19)30-22/h3-10,14,17-18,27H,11-13H2,1-2H3,(H,24,28)/t14-,17-,18+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183446
PNG
(US9670142, A46 4-(1H-indazol-6-yl)-N-methyl-N-((1R...)
Show SMILES CCC(=O)N[C@H]1CCC(C1)N(C)C(=O)c1ccc(cc1)-c1ccc2cn[nH]c2c1
Show InChI InChI=1S/C23H26N4O2/c1-3-22(28)25-19-10-11-20(13-19)27(2)23(29)16-6-4-15(5-7-16)17-8-9-18-14-24-26-21(18)12-17/h4-9,12,14,19-20H,3,10-11,13H2,1-2H3,(H,24,26)(H,25,28)/t19-,20?/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183471
PNG
(US9670142, A52 3-methyl-4'-[methyl-((1R,3S)-3-...)
Show SMILES CCC(=O)N[C@H]1CCC(C1)N(C)C(=O)c1ccc(cc1)-c1ccc(C(O)=O)c(C)c1
Show InChI InChI=1S/C24H28N2O4/c1-4-22(27)25-19-10-11-20(14-19)26(3)23(28)17-7-5-16(6-8-17)18-9-12-21(24(29)30)15(2)13-18/h5-9,12-13,19-20H,4,10-11,14H2,1-3H3,(H,25,27)(H,29,30)/t19-,20?/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183477
PNG
(US9670142, A57 biphenyl-4,4'-dicarboxylic acid...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(cc1)C(N)=O
Show InChI InChI=1S/C23H27N3O3/c1-3-21(27)25-19-12-13-20(14-19)26(2)23(29)18-10-6-16(7-11-18)15-4-8-17(9-5-15)22(24)28/h4-11,19-20H,3,12-14H2,1-2H3,(H2,24,28)(H,25,27)/t19-,20+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183532
PNG
(US9670142, A64 4'-trifluoromethyl-biphenyl-4-c...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C23H25F3N2O2/c1-3-21(29)27-19-12-13-20(14-19)28(2)22(30)17-6-4-15(5-7-17)16-8-10-18(11-9-16)23(24,25)26/h4-11,19-20H,3,12-14H2,1-2H3,(H,27,29)/t19-,20+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183534
PNG
(US9670142, A65 4'-methoxy-2'-methyl-biphen...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(OC)cc1C
Show InChI InChI=1S/C24H30N2O3/c1-5-23(27)25-19-10-11-20(15-19)26(3)24(28)18-8-6-17(7-9-18)22-13-12-21(29-4)14-16(22)2/h6-9,12-14,19-20H,5,10-11,15H2,1-4H3,(H,25,27)/t19-,20+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183559
PNG
(US9670142, A70 4'-cyclopropylmethoxy-biphenyl-...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(OCC2CC2)cc1
Show InChI InChI=1S/C26H32N2O3/c1-3-25(29)27-22-12-13-23(16-22)28(2)26(30)21-8-6-19(7-9-21)20-10-14-24(15-11-20)31-17-18-4-5-18/h6-11,14-15,18,22-23H,3-5,12-13,16-17H2,1-2H3,(H,27,29)/t22-,23+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183625
PNG
(US9670142, A82 4'-methoxy-biphenyl-4-carboxyli...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(OC)cc1
Show InChI InChI=1S/C23H28N2O3/c1-4-22(26)24-19-11-12-20(15-19)25(2)23(27)18-7-5-16(6-8-18)17-9-13-21(28-3)14-10-17/h5-10,13-14,19-20H,4,11-12,15H2,1-3H3,(H,24,26)/t19-,20+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183626
PNG
(US9670142, A83 2',4'-difluoro-biphenyl-4-c...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(F)cc1F
Show InChI InChI=1S/C22H24F2N2O2/c1-3-21(27)25-17-9-10-18(13-17)26(2)22(28)15-6-4-14(5-7-15)19-11-8-16(23)12-20(19)24/h4-8,11-12,17-18H,3,9-10,13H2,1-2H3,(H,25,27)/t17-,18+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183632
PNG
(US9670142, A85 4'-difluoromethoxy-biphenyl-4-c...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C23H26F2N2O3/c1-3-21(28)26-18-10-11-19(14-18)27(2)22(29)17-6-4-15(5-7-17)16-8-12-20(13-9-16)30-23(24)25/h4-9,12-13,18-19,23H,3,10-11,14H2,1-2H3,(H,26,28)/t18-,19+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM182959
PNG
(US9670142, A21 4-benzoxazol-2-yl-N-[(1R,3S)-3-(cyc...)
Show SMILES CN([C@@H]1CC[C@@H](C1)NC(=O)C1CCCC1)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C26H29N3O3/c1-29(21-15-14-20(16-21)27-24(30)17-6-2-3-7-17)26(31)19-12-10-18(11-13-19)25-28-22-8-4-5-9-23(22)32-25/h4-5,8-13,17,20-21H,2-3,6-7,14-16H2,1H3,(H,27,30)/t20-,21+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM182863
PNG
(US9670142, A1 4-benzoxazol-2-yl-N-methyl-N-((1R,3S...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C23H25N3O3/c1-3-21(27)24-17-12-13-18(14-17)26(2)23(28)16-10-8-15(9-11-16)22-25-19-6-4-5-7-20(19)29-22/h4-11,17-18H,3,12-14H2,1-2H3,(H,24,27)/t17-,18+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM182864
PNG
(US9670142, A2 4-benzoxazol-2-yl-N-[(1R,3S)-3-(cycl...)
Show SMILES CN([C@@H]1CC[C@@H](C1)NC(=O)C1CC1)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C24H25N3O3/c1-27(19-13-12-18(14-19)25-22(28)15-6-7-15)24(29)17-10-8-16(9-11-17)23-26-20-4-2-3-5-21(20)30-23/h2-5,8-11,15,18-19H,6-7,12-14H2,1H3,(H,25,28)/t18-,19+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM182946
PNG
(US9670142, A8 biphenyl-4-carboxylic acid methyl-((...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C22H26N2O2/c1-3-21(25)23-19-13-14-20(15-19)24(2)22(26)18-11-9-17(10-12-18)16-7-5-4-6-8-16/h4-12,19-20H,3,13-15H2,1-2H3,(H,23,25)/t19-,20+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM182956
PNG
(US9670142, A18 N-((1R,3S)-3-acetylamino-cyclopenty...)
Show SMILES CN([C@@H]1CC[C@@H](C1)NC(C)=O)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C22H23N3O3/c1-14(26)23-17-11-12-18(13-17)25(2)22(27)16-9-7-15(8-10-16)21-24-19-5-3-4-6-20(19)28-21/h3-10,17-18H,11-13H2,1-2H3,(H,23,26)/t17-,18+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM182957
PNG
(US9670142, A19 4-benzoxazol-2-yl-N-methyl-N-[(1R,3...)
Show SMILES CC(C)CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C26H31N3O3/c1-17(2)8-15-24(30)27-20-13-14-21(16-20)29(3)26(31)19-11-9-18(10-12-19)25-28-22-6-4-5-7-23(22)32-25/h4-7,9-12,17,20-21H,8,13-16H2,1-3H3,(H,27,30)/t20-,21+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM184405
PNG
(US9670142, A90 2',4'-dimethyl-biphenyl-4-c...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(C)cc1C
Show InChI InChI=1S/C24H30N2O2/c1-5-23(27)25-20-11-12-21(15-20)26(4)24(28)19-9-7-18(8-10-19)22-13-6-16(2)14-17(22)3/h6-10,13-14,20-21H,5,11-12,15H2,1-4H3,(H,25,27)/t20-,21+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM184407
PNG
(US9670142, A92 4'-chloro-2'-fluoro-bipheny...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(Cl)cc1F
Show InChI InChI=1S/C22H24ClFN2O2/c1-3-21(27)25-17-9-10-18(13-17)26(2)22(28)15-6-4-14(5-7-15)19-11-8-16(23)12-20(19)24/h4-8,11-12,17-18H,3,9-10,13H2,1-2H3,(H,25,27)/t17-,18+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183615
PNG
(US9670142, A79 fluoro-4'-trifluoromethoxy-biph...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(OC(F)(F)F)c(F)c1
Show InChI InChI=1S/C23H24F4N2O3/c1-3-21(30)28-17-9-10-18(13-17)29(2)22(31)15-6-4-14(5-7-15)16-8-11-20(19(24)12-16)32-23(25,26)27/h4-8,11-12,17-18H,3,9-10,13H2,1-2H3,(H,28,30)/t17-,18+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM184414
PNG
(US9670142, A99 2'-fluoro-4'-methoxy-biphen...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(COC)cc1F
Show InChI InChI=1S/C24H29FN2O3/c1-4-23(28)26-19-10-11-20(14-19)27(2)24(29)18-8-6-17(7-9-18)21-12-5-16(15-30-3)13-22(21)25/h5-9,12-13,19-20H,4,10-11,14-15H2,1-3H3,(H,26,28)/t19-,20+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM184478
PNG
(US9670142, A102 N-methyl-4-(6-methyl-1H-indazol-5-...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1cc2cn[nH]c2cc1C
Show InChI InChI=1S/C24H28N4O2/c1-4-23(29)26-19-9-10-20(13-19)28(3)24(30)17-7-5-16(6-8-17)21-12-18-14-25-27-22(18)11-15(21)2/h5-8,11-12,14,19-20H,4,9-10,13H2,1-3H3,(H,25,27)(H,26,29)/t19-,20+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM184550
PNG
(US9670142, A113 6-(1H-indol-5-yl)-pyridazine-3-car...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(nn1)-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C22H25N5O2/c1-3-21(28)24-16-5-6-17(13-16)27(2)22(29)20-9-8-19(25-26-20)14-4-7-18-15(12-14)10-11-23-18/h4,7-12,16-17,23H,3,5-6,13H2,1-2H3,(H,24,28)/t16-,17+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM185360
PNG
(US9670142, A118 6-(1-methyl-1H-indol-5-yl)-pyridaz...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(nn1)-c1ccc2n(C)ccc2c1
Show InChI InChI=1S/C23H27N5O2/c1-4-22(29)24-17-6-7-18(14-17)28(3)23(30)20-9-8-19(25-26-20)15-5-10-21-16(13-15)11-12-27(21)2/h5,8-13,17-18H,4,6-7,14H2,1-3H3,(H,24,29)/t17-,18+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM185507
PNG
(US9670142, A119 2,N-dimethyl-4-(1-methyl-1H-indol-...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1C)-c1ccc2n(C)ccc2c1
Show InChI InChI=1S/C26H31N3O2/c1-5-25(30)27-21-8-9-22(16-21)29(4)26(31)23-10-6-18(14-17(23)2)19-7-11-24-20(15-19)12-13-28(24)3/h6-7,10-15,21-22H,5,8-9,16H2,1-4H3,(H,27,30)/t21-,22+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM185533
PNG
(US9670142, A124 3,N-dimethyl-4-(4-methyl-1H-indazo...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(c(C)c1)-c1ccc2[nH]ncc2c1C
Show InChI InChI=1S/C25H30N4O2/c1-5-24(30)27-18-7-8-19(13-18)29(4)25(31)17-6-9-20(15(2)12-17)21-10-11-23-22(16(21)3)14-26-28-23/h6,9-12,14,18-19H,5,7-8,13H2,1-4H3,(H,26,28)(H,27,30)/t18-,19+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM185537
PNG
(US9670142, A125 5-(1-methyl-1H-indol-5-yl)-pyrazin...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1cnc(cn1)-c1ccc2n(C)ccc2c1
Show InChI InChI=1S/C23H27N5O2/c1-4-22(29)26-17-6-7-18(12-17)28(3)23(30)20-14-24-19(13-25-20)15-5-8-21-16(11-15)9-10-27(21)2/h5,8-11,13-14,17-18H,4,6-7,12H2,1-3H3,(H,26,29)/t17-,18+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM185542
PNG
(US9670142, A127 4-(6-fluoro-benzoxazol-2-yl)-N-met...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1nc2ccc(F)cc2o1
Show InChI InChI=1S/C23H24FN3O3/c1-3-21(28)25-17-9-10-18(13-17)27(2)23(29)15-6-4-14(5-7-15)22-26-19-11-8-16(24)12-20(19)30-22/h4-8,11-12,17-18H,3,9-10,13H2,1-2H3,(H,25,28)/t17-,18+/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM185650
PNG
(US9670142, A138 (S)-tetrahydro-furan-2-carboxylic ...)
Show SMILES CN([C@@H]1CC[C@@H](C1)NC(=O)[C@@H]1CCCO1)C(=O)c1ccc(cc1)-c1nc2ccc(Cl)cc2o1
Show InChI InChI=1S/C25H26ClN3O4/c1-29(19-10-9-18(14-19)27-23(30)21-3-2-12-32-21)25(31)16-6-4-15(5-7-16)24-28-20-11-8-17(26)13-22(20)33-24/h4-8,11,13,18-19,21H,2-3,9-10,12,14H2,1H3,(H,27,30)/t18-,19+,21-/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186320
PNG
(US9670142, A160 5-{2-fluoro-4-[methyl-((1R,3S)-3-p...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(c(F)c1)-c1ccc2[nH]cc(C(N)=O)c2c1
Show InChI InChI=1S/C25H27FN4O3/c1-3-23(31)29-16-6-7-17(12-16)30(2)25(33)15-4-8-18(21(26)11-15)14-5-9-22-19(10-14)20(13-28-22)24(27)32/h4-5,8-11,13,16-17,28H,3,6-7,12H2,1-2H3,(H2,27,32)(H,29,31)/t16-,17+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183001
PNG
(US9670142, A31 4-benzoxazol-2-yl-N-methyl-N-[(1R,3...)
Show SMILES CC[C@@H](C)CC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C26H31N3O3/c1-4-17(2)15-24(30)27-20-13-14-21(16-20)29(3)26(31)19-11-9-18(10-12-19)25-28-22-7-5-6-8-23(22)32-25/h5-12,17,20-21H,4,13-16H2,1-3H3,(H,27,30)/t17-,20+,21-/m1/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183470
PNG
(US9670142, A51 4'-[methyl-((1R,3S)-3-propionyl...)
Show SMILES CCC(=O)N[C@H]1CCC(C1)N(C)C(=O)c1ccc(cc1)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H26N2O4/c1-3-21(26)24-19-12-13-20(14-19)25(2)22(27)17-8-4-15(5-9-17)16-6-10-18(11-7-16)23(28)29/h4-11,19-20H,3,12-14H2,1-2H3,(H,24,26)(H,28,29)/t19-,20?/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM182961
PNG
(US9670142, A23 4-benzoxazol-2-yl-N-methyl-N-((1R,3...)
Show SMILES CN([C@@H]1CC[C@@H](C1)NC(=O)Cc1ccccc1)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C28H27N3O3/c1-31(23-16-15-22(18-23)29-26(32)17-19-7-3-2-4-8-19)28(33)21-13-11-20(12-14-21)27-30-24-9-5-6-10-25(24)34-27/h2-14,22-23H,15-18H2,1H3,(H,29,32)/t22-,23+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM182962
PNG
(US9670142, A24 4-benzoxazol-2-yl-N-methyl-N-((1R,3...)
Show SMILES CCCCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C25H29N3O3/c1-3-4-9-23(29)26-19-14-15-20(16-19)28(2)25(30)18-12-10-17(11-13-18)24-27-21-7-5-6-8-22(21)31-24/h5-8,10-13,19-20H,3-4,9,14-16H2,1-2H3,(H,26,29)/t19-,20+/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM182941
PNG
(US9670142, A3 4-benzoxazol-2-yl-N-methyl-N-{(1R,3S...)
Show SMILES CN([C@@H]1CC[C@@H](C1)NC(=O)C1(C)CC1)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C25H27N3O3/c1-25(13-14-25)24(30)26-18-11-12-19(15-18)28(2)23(29)17-9-7-16(8-10-17)22-27-20-5-3-4-6-21(20)31-22/h3-10,18-19H,11-15H2,1-2H3,(H,26,30)/t18-,19+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM182945
PNG
(US9670142, A7 4-(1H-benzimidazol-2-yl)-N-methyl-N-...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C23H26N4O2/c1-3-21(28)24-17-12-13-18(14-17)27(2)23(29)16-10-8-15(9-11-16)22-25-19-6-4-5-7-20(19)26-22/h4-11,17-18H,3,12-14H2,1-2H3,(H,24,28)(H,25,26)/t17-,18+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM182950
PNG
(US9670142, A12 4'-cyano-biphenyl-4-carboxylic ...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H25N3O2/c1-3-22(27)25-20-12-13-21(14-20)26(2)23(28)19-10-8-18(9-11-19)17-6-4-16(15-24)5-7-17/h4-11,20-21H,3,12-14H2,1-2H3,(H,25,27)/t20-,21+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM182955
PNG
(US9670142, A17 5-benzoxazol-2-yl-pyridine-2-carbox...)
Show SMILES CC(C)C(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cn1)-c1nc2ccccc2o1
Show InChI InChI=1S/C23H26N4O3/c1-14(2)21(28)25-16-9-10-17(12-16)27(3)23(29)19-11-8-15(13-24-19)22-26-18-6-4-5-7-20(18)30-22/h4-8,11,13-14,16-17H,9-10,12H2,1-3H3,(H,25,28)/t16-,17+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183634
PNG
(US9670142, A87 4-(2,3-dihydro-benzo[1,4]dioxin-6-y...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc2OCCOc2c1
Show InChI InChI=1S/C24H28N2O4/c1-3-23(27)25-19-9-10-20(15-19)26(2)24(28)17-6-4-16(5-7-17)18-8-11-21-22(14-18)30-13-12-29-21/h4-8,11,14,19-20H,3,9-10,12-13,15H2,1-2H3,(H,25,27)/t19-,20+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM184406
PNG
(US9670142, A91 4-(1H-benzotriazol-5-yl)-N-methyl-N...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc2[nH]nnc2c1
Show InChI InChI=1S/C22H25N5O2/c1-3-21(28)23-17-9-10-18(13-17)27(2)22(29)15-6-4-14(5-7-15)16-8-11-19-20(12-16)25-26-24-19/h4-8,11-12,17-18H,3,9-10,13H2,1-2H3,(H,23,28)(H,24,25,26)/t17-,18+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM184412
PNG
(US9670142, A97 2-fluoro-4'-[methyl-((1R,3S)-3-...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(cc1F)C(=O)OC
Show InChI InChI=1S/C24H27FN2O4/c1-4-22(28)26-18-10-11-19(14-18)27(2)23(29)16-7-5-15(6-8-16)20-12-9-17(13-21(20)25)24(30)31-3/h5-9,12-13,18-19H,4,10-11,14H2,1-3H3,(H,26,28)/t18-,19+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM185517
PNG
(US9670142, A121 4-(7-fluoro-1H-indol-5-yl)-N-methy...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1cc(F)c2[nH]ccc2c1
Show InChI InChI=1S/C24H26FN3O2/c1-3-22(29)27-19-8-9-20(14-19)28(2)24(30)16-6-4-15(5-7-16)18-12-17-10-11-26-23(17)21(25)13-18/h4-7,10-13,19-20,26H,3,8-9,14H2,1-2H3,(H,27,29)/t19-,20+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM185565
PNG
(US9670142, A133 5-(1-methyl-1H-indol-5-yl)-pyrimid...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ncc(cn1)-c1ccc2n(C)ccc2c1
Show InChI InChI=1S/C23H27N5O2/c1-4-21(29)26-18-6-7-19(12-18)28(3)23(30)22-24-13-17(14-25-22)15-5-8-20-16(11-15)9-10-27(20)2/h5,8-11,13-14,18-19H,4,6-7,12H2,1-3H3,(H,26,29)/t18-,19+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186089
PNG
(US9670142, A139 2-(1H-indol-5-yl)-pyrimidine-5-car...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1cnc(nc1)-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C22H25N5O2/c1-3-20(28)26-17-5-6-18(11-17)27(2)22(29)16-12-24-21(25-13-16)15-4-7-19-14(10-15)8-9-23-19/h4,7-10,12-13,17-18,23H,3,5-6,11H2,1-2H3,(H,26,28)/t17-,18+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186090
PNG
(US9670142, A140 5-fluoro-6-(1H-indol-5-yl)-N-methy...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1cnc(c(F)c1)-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C23H25FN4O2/c1-3-21(29)27-17-5-6-18(12-17)28(2)23(30)16-11-19(24)22(26-13-16)15-4-7-20-14(10-15)8-9-25-20/h4,7-11,13,17-18,25H,3,5-6,12H2,1-2H3,(H,27,29)/t17-,18+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186310
PNG
(US9670142, A151 3-fluoro-4-(4-fluoro-1H-indol-5-yl...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(c(F)c1)-c1ccc2[nH]ccc2c1F
Show InChI InChI=1S/C24H25F2N3O2/c1-3-22(30)28-15-5-6-16(13-15)29(2)24(31)14-4-7-17(20(25)12-14)18-8-9-21-19(23(18)26)10-11-27-21/h4,7-12,15-16,27H,3,5-6,13H2,1-2H3,(H,28,30)/t15-,16+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186804
PNG
(US9670142, A175 (S)-tetrahydro-furan-2-carboxylic ...)
Show SMILES CN([C@@H]1CC[C@@H](C1)NC(=O)[C@@H]1CCCO1)C(=O)c1ccc(cc1F)-c1nc2ccccc2o1
Show InChI InChI=1S/C25H26FN3O4/c1-29(17-10-9-16(14-17)27-23(30)22-7-4-12-32-22)25(31)18-11-8-15(13-19(18)26)24-28-20-5-2-3-6-21(20)33-24/h2-3,5-6,8,11,13,16-17,22H,4,7,9-10,12,14H2,1H3,(H,27,30)/t16-,17+,22-/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183063
PNG
(US9670142, A35 4-benzoxazol-2-yl-N-methyl-N-[(1R,3...)
Show SMILES CC(C)CC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C25H29N3O3/c1-16(2)14-23(29)26-19-12-13-20(15-19)28(3)25(30)18-10-8-17(9-11-18)24-27-21-6-4-5-7-22(21)31-24/h4-11,16,19-20H,12-15H2,1-3H3,(H,26,29)/t19-,20+/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183463
PNG
(US9670142, A49 4-(7-fluoro-benzoxazol-2-yl)-N-meth...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1nc2cccc(F)c2o1
Show InChI InChI=1S/C23H24FN3O3/c1-3-20(28)25-16-11-12-17(13-16)27(2)23(29)15-9-7-14(8-10-15)22-26-19-6-4-5-18(24)21(19)30-22/h4-10,16-17H,3,11-13H2,1-2H3,(H,25,28)/t16-,17+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM182942
PNG
(US9670142, A4 N-methyl-N-((1R,3S)-3-propionylamino...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C21H25N3O2/c1-3-20(25)23-18-8-9-19(14-18)24(2)21(26)17-6-4-15(5-7-17)16-10-12-22-13-11-16/h4-7,10-13,18-19H,3,8-9,14H2,1-2H3,(H,23,25)/t18-,19+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM182947
PNG
(US9670142, A9 4-(5-chloro-benzoxazol-2-yl)-N-methy...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1nc2cc(Cl)ccc2o1
Show InChI InChI=1S/C23H24ClN3O3/c1-3-21(28)25-17-9-10-18(13-17)27(2)23(29)15-6-4-14(5-7-15)22-26-19-12-16(24)8-11-20(19)30-22/h4-8,11-12,17-18H,3,9-10,13H2,1-2H3,(H,25,28)/t17-,18+/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM182971
PNG
(US9670142, A29 N-((1R,3S)-3-ethylcarbamoyl-cyclope...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1cccc2[nH]ncc12
Show InChI InChI=1S/C23H26N4O2/c1-3-22(28)25-17-11-12-18(13-17)27(2)23(29)16-9-7-15(8-10-16)19-5-4-6-21-20(19)14-24-26-21/h4-10,14,17-18H,3,11-13H2,1-2H3,(H,24,26)(H,25,28)/t17-,18+/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM184418
PNG
(US9670142, A101 4-(1H-indol-5-yl)-3,N-dimethyl-N-(...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(c(C)c1)-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C25H29N3O2/c1-4-24(29)27-20-7-8-21(15-20)28(3)25(30)19-5-9-22(16(2)13-19)17-6-10-23-18(14-17)11-12-26-23/h5-6,9-14,20-21,26H,4,7-8,15H2,1-3H3,(H,27,29)/t20-,21+/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM184540
PNG
(US9670142, A110 5-(1-methyl-1H-indol-5-yl)-pyridin...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cn1)-c1ccc2n(C)ccc2c1
Show InChI InChI=1S/C24H28N4O2/c1-4-23(29)26-19-7-8-20(14-19)28(3)24(30)21-9-5-18(15-25-21)16-6-10-22-17(13-16)11-12-27(22)2/h5-6,9-13,15,19-20H,4,7-8,14H2,1-3H3,(H,26,29)/t19-,20+/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM184541
PNG
(US9670142, A111 2-fluoro-N-methyl-4-(1-methyl-1H-i...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1F)-c1ccc2n(C)ccc2c1
Show InChI InChI=1S/C25H28FN3O2/c1-4-24(30)27-19-7-8-20(15-19)29(3)25(31)21-9-5-17(14-22(21)26)16-6-10-23-18(13-16)11-12-28(23)2/h5-6,9-14,19-20H,4,7-8,15H2,1-3H3,(H,27,30)/t19-,20+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM185567
PNG
(US9670142, A135 6-(4-fluoro-1H-indol-5-yl)-N-methy...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(nc1)-c1ccc2[nH]ccc2c1F
Show InChI InChI=1S/C23H25FN4O2/c1-3-21(29)27-15-5-6-16(12-15)28(2)23(30)14-4-8-20(26-13-14)17-7-9-19-18(22(17)24)10-11-25-19/h4,7-11,13,15-16,25H,3,5-6,12H2,1-2H3,(H,27,29)/t15-,16+/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186116
PNG
(US9670142, A146 6-(4-fluoro-1H-indol-5-yl)-4,N-dim...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1cnc(cc1C)-c1ccc2[nH]ccc2c1F
Show InChI InChI=1S/C24H27FN4O2/c1-4-22(30)28-15-5-6-16(12-15)29(3)24(31)19-13-27-21(11-14(19)2)17-7-8-20-18(23(17)25)9-10-26-20/h7-11,13,15-16,26H,4-6,12H2,1-3H3,(H,28,30)/t15-,16+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186311
PNG
(US9670142, A152 4-(3-aminomethyl-1-methyl-1H-indol...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc2n(C)cc(CN)c2c1
Show InChI InChI=1S/C26H32N4O2/c1-4-25(31)28-21-10-11-22(14-21)30(3)26(32)18-7-5-17(6-8-18)19-9-12-24-23(13-19)20(15-27)16-29(24)2/h5-9,12-13,16,21-22H,4,10-11,14-15,27H2,1-3H3,(H,28,31)/t21-,22+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186316
PNG
(US9670142, A157 6-(7-fluoro-1H-indol-6-yl)-N-methy...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(nc1)-c1ccc2cc[nH]c2c1F
Show InChI InChI=1S/C23H25FN4O2/c1-3-20(29)27-16-6-7-17(12-16)28(2)23(30)15-5-9-19(26-13-15)18-8-4-14-10-11-25-22(14)21(18)24/h4-5,8-11,13,16-17,25H,3,6-7,12H2,1-2H3,(H,27,29)/t16-,17+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183476
PNG
(US9670142, A56 3',4'-dimethoxy-biphenyl-4-...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C24H30N2O4/c1-5-23(27)25-19-11-12-20(15-19)26(2)24(28)17-8-6-16(7-9-17)18-10-13-21(29-3)22(14-18)30-4/h6-10,13-14,19-20H,5,11-12,15H2,1-4H3,(H,25,27)/t19-,20+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183485
PNG
(US9670142, A60 N-methyl-4-(2-oxo-2,3-dihydro-1H-in...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc2CC(=O)Nc2c1
Show InChI InChI=1S/C24H27N3O3/c1-3-22(28)25-19-10-11-20(14-19)27(2)24(30)16-6-4-15(5-7-16)17-8-9-18-13-23(29)26-21(18)12-17/h4-9,12,19-20H,3,10-11,13-14H2,1-2H3,(H,25,28)(H,26,29)/t19-,20+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183604
PNG
(US9670142, A77 cyano-2'-fluoro-biphenyl-4-carb...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(cc1F)C#N
Show InChI InChI=1S/C23H24FN3O2/c1-3-22(28)26-18-9-10-19(13-18)27(2)23(29)17-7-5-16(6-8-17)20-11-4-15(14-25)12-21(20)24/h4-8,11-12,18-19H,3,9-10,13H2,1-2H3,(H,26,28)/t18-,19+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183615
PNG
(US9670142, A79 fluoro-4'-trifluoromethoxy-biph...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(OC(F)(F)F)c(F)c1
Show InChI InChI=1S/C23H24F4N2O3/c1-3-21(30)28-17-9-10-18(13-17)29(2)22(31)15-6-4-14(5-7-15)16-8-11-20(19(24)12-16)32-23(25,26)27/h4-8,11-12,17-18H,3,9-10,13H2,1-2H3,(H,28,30)/t17-,18+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183616
PNG
(US9670142, A80 N-methyl-4-(1-methyl-1H-indol-5-yl)...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc2n(C)ccc2c1
Show InChI InChI=1S/C25H29N3O2/c1-4-24(29)26-21-10-11-22(16-21)28(3)25(30)18-7-5-17(6-8-18)19-9-12-23-20(15-19)13-14-27(23)2/h5-9,12-15,21-22H,4,10-11,16H2,1-3H3,(H,26,29)/t21-,22+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM184410
PNG
(US9670142, A95 4-(1H-indol-5-yl)-N-methyl-N-((1R,3...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C24H27N3O2/c1-3-23(28)26-20-9-10-21(15-20)27(2)24(29)17-6-4-16(5-7-17)18-8-11-22-19(14-18)12-13-25-22/h4-8,11-14,20-21,25H,3,9-10,15H2,1-2H3,(H,26,28)/t20-,21+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM184492
PNG
(US9670142, A104 5-(7-methyl-1H-indazol-5-yl)-pyrid...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cn1)-c1cc(C)c2[nH]ncc2c1
Show InChI InChI=1S/C23H27N5O2/c1-4-21(29)26-18-6-7-19(11-18)28(3)23(30)20-8-5-15(12-24-20)16-9-14(2)22-17(10-16)13-25-27-22/h5,8-10,12-13,18-19H,4,6-7,11H2,1-3H3,(H,25,27)(H,26,29)/t18-,19+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM184538
PNG
(US9670142, A108 3-fluoro-N-methyl-4-(1-methyl-1H-i...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(c(F)c1)-c1ccc2n(C)ccc2c1
Show InChI InChI=1S/C25H28FN3O2/c1-4-24(30)27-19-7-8-20(15-19)29(3)25(31)18-5-9-21(22(26)14-18)16-6-10-23-17(13-16)11-12-28(23)2/h5-6,9-14,19-20H,4,7-8,15H2,1-3H3,(H,27,30)/t19-,20+/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM184547
PNG
(US9670142, A112 3-fluoro-4-(1H-indol-5-yl)-N-methy...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(c(F)c1)-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C24H26FN3O2/c1-3-23(29)27-18-6-7-19(14-18)28(2)24(30)17-4-8-20(21(25)13-17)15-5-9-22-16(12-15)10-11-26-22/h4-5,8-13,18-19,26H,3,6-7,14H2,1-2H3,(H,27,29)/t18-,19+/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM184573
PNG
(US9670142, A114 3,N-dimethyl-4-(1-methyl-1H-indol-...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(c(C)c1)-c1ccc2n(C)ccc2c1
Show InChI InChI=1S/C26H31N3O2/c1-5-25(30)27-21-8-9-22(16-21)29(4)26(31)20-6-10-23(17(2)14-20)18-7-11-24-19(15-18)12-13-28(24)3/h6-7,10-15,21-22H,5,8-9,16H2,1-4H3,(H,27,30)/t21-,22+/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM185516
PNG
(US9670142, A120 4-(1H-indol-5-yl)-2,N-dimethyl-N-(...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1C)-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C25H29N3O2/c1-4-24(29)27-20-7-8-21(15-20)28(3)25(30)22-9-5-17(13-16(22)2)18-6-10-23-19(14-18)11-12-26-23/h5-6,9-14,20-21,26H,4,7-8,15H2,1-3H3,(H,27,29)/t20-,21+/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM185540
PNG
(US9670142, A126 N-methyl-4-(4-methyl-1H-indazol-5-...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc2[nH]ncc2c1C
Show InChI InChI=1S/C24H28N4O2/c1-4-23(29)26-18-9-10-19(13-18)28(3)24(30)17-7-5-16(6-8-17)20-11-12-22-21(15(20)2)14-25-27-22/h5-8,11-12,14,18-19H,4,9-10,13H2,1-3H3,(H,25,27)(H,26,29)/t18-,19+/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM185564
PNG
(US9670142, A132 5-(1H-indol-5-yl)-pyrazine-2-carbo...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1cnc(cn1)-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C22H25N5O2/c1-3-21(28)26-16-5-6-17(11-16)27(2)22(29)20-13-24-19(12-25-20)14-4-7-18-15(10-14)8-9-23-18/h4,7-10,12-13,16-17,23H,3,5-6,11H2,1-2H3,(H,26,28)/t16-,17+/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186312
PNG
(US9670142, A153 6-(6-chloro-benzoxazol-2-yl)-N-met...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(nc1)-c1nc2ccc(Cl)cc2o1
Show InChI InChI=1S/C22H23ClN4O3/c1-3-20(28)25-15-6-7-16(11-15)27(2)22(29)13-4-8-18(24-12-13)21-26-17-9-5-14(23)10-19(17)30-21/h4-5,8-10,12,15-16H,3,6-7,11H2,1-2H3,(H,25,28)/t15-,16+/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186313
PNG
(US9670142, A154 6-(6-chloro-benzoxazol-2-yl)-N-met...)
Show SMILES CN([C@@H]1CC[C@@H](C1)NC(=O)[C@@H]1CCCO1)C(=O)c1ccc(nc1)-c1nc2ccc(Cl)cc2o1
Show InChI InChI=1S/C24H25ClN4O4/c1-29(17-7-6-16(12-17)27-22(30)20-3-2-10-32-20)24(31)14-4-8-19(26-13-14)23-28-18-9-5-15(25)11-21(18)33-23/h4-5,8-9,11,13,16-17,20H,2-3,6-7,10,12H2,1H3,(H,27,30)/t16-,17+,20-/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183535
PNG
(US9670142, A66 3'-fluoro-4'-methyl-bipheny...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(C)c(F)c1
Show InChI InChI=1S/C23H27FN2O2/c1-4-22(27)25-19-11-12-20(14-19)26(3)23(28)17-9-7-16(8-10-17)18-6-5-15(2)21(24)13-18/h5-10,13,19-20H,4,11-12,14H2,1-3H3,(H,25,27)/t19-,20+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183576
PNG
(US9670142, A74 N-methyl-4-(1-methyl-1H-indazol-6-y...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc2cnn(C)c2c1
Show InChI InChI=1S/C24H28N4O2/c1-4-23(29)26-20-11-12-21(14-20)27(2)24(30)17-7-5-16(6-8-17)18-9-10-19-15-25-28(3)22(19)13-18/h5-10,13,15,20-21H,4,11-12,14H2,1-3H3,(H,26,29)/t20-,21+/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183609
PNG
(US9670142, A78 biphenyl-4,4'-dicarboxylic acid...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(cc1)C(=O)NC
Show InChI InChI=1S/C24H29N3O3/c1-4-22(28)26-20-13-14-21(15-20)27(3)24(30)19-11-7-17(8-12-19)16-5-9-18(10-6-16)23(29)25-2/h5-12,20-21H,4,13-15H2,1-3H3,(H,25,29)(H,26,28)/t20-,21+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM182943
PNG
(US9670142, A5 4'-chloro-biphenyl-4-carboxylic ...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H25ClN2O2/c1-3-21(26)24-19-12-13-20(14-19)25(2)22(27)17-6-4-15(5-7-17)16-8-10-18(23)11-9-16/h4-11,19-20H,3,12-14H2,1-2H3,(H,24,26)/t19-,20+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM182948
PNG
(US9670142, A10 4-imidazo[1,2-a]pyrimidin-2-yl-N-me...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1cn2cccnc2n1
Show InChI InChI=1S/C22H25N5O2/c1-3-20(28)24-17-9-10-18(13-17)26(2)21(29)16-7-5-15(6-8-16)19-14-27-12-4-11-23-22(27)25-19/h4-8,11-12,14,17-18H,3,9-10,13H2,1-2H3,(H,24,28)/t17-,18+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM182953
PNG
(US9670142, A15 N-methyl-N-((1R,3S)-3-propionylamin...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)C#Cc1ccncc1
Show InChI InChI=1S/C23H25N3O2/c1-3-22(27)25-20-10-11-21(16-20)26(2)23(28)19-8-6-17(7-9-19)4-5-18-12-14-24-15-13-18/h6-9,12-15,20-21H,3,10-11,16H2,1-2H3,(H,25,27)/t20-,21+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM184408
PNG
(US9670142, A93 N-methyl-4-(2-oxo-2,3-dihydro-1H-be...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C23H24N4O3/c1-3-21(28)24-17-9-10-18(13-17)27(2)22(29)15-6-4-14(5-7-15)16-8-11-19-20(12-16)26-23(30)25-19/h4-8,11-12,17-18H,3,9-10,13H2,1-2H3,(H,24,28)/t17-,18+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM184415
PNG
(US9670142, A99a 4-(3-cyano-1H-indol-5-yl)-N-methyl...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc2[nH]cc(C#N)c2c1
Show InChI InChI=1S/C25H26N4O2/c1-3-24(30)28-20-9-10-21(13-20)29(2)25(31)17-6-4-16(5-7-17)18-8-11-23-22(12-18)19(14-26)15-27-23/h4-8,11-12,15,20-21,27H,3,9-10,13H2,1-2H3,(H,28,30)/t20-,21+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM184416
PNG
(US9670142, A100 N-methyl-4-(3-methyl-1H-indazol-5-...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc2[nH]nc(C)c2c1
Show InChI InChI=1S/C24H28N4O2/c1-4-23(29)25-19-10-11-20(14-19)28(3)24(30)17-7-5-16(6-8-17)18-9-12-22-21(13-18)15(2)26-27-22/h5-9,12-13,19-20H,4,10-11,14H2,1-3H3,(H,25,29)(H,26,27)/t19-,20+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM184493
PNG
(US9670142, A105 5-(3-methyl-1H-indazol-5-yl)-pyrid...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cn1)-c1ccc2[nH]nc(C)c2c1
Show InChI InChI=1S/C23H27N5O2/c1-4-22(29)25-17-7-8-18(12-17)28(3)23(30)21-10-6-16(13-24-21)15-5-9-20-19(11-15)14(2)26-27-20/h5-6,9-11,13,17-18H,4,7-8,12H2,1-3H3,(H,25,29)(H,26,27)/t17-,18+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM184499
PNG
(US9670142, A106 2-fluoro-4-(1H-indol-5-yl)-N-methy...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1F)-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C24H26FN3O2/c1-3-23(29)27-18-6-7-19(14-18)28(2)24(30)20-8-4-16(13-21(20)25)15-5-9-22-17(12-15)10-11-26-22/h4-5,8-13,18-19,26H,3,6-7,14H2,1-2H3,(H,27,29)/t18-,19+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM184537
PNG
(US9670142, A107 N-methyl-4-(7-methyl-1H-indazol-5-...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1cc(C)c2[nH]ncc2c1
Show InChI InChI=1S/C24H28N4O2/c1-4-22(29)26-20-9-10-21(13-20)28(3)24(30)17-7-5-16(6-8-17)18-11-15(2)23-19(12-18)14-25-27-23/h5-8,11-12,14,20-21H,4,9-10,13H2,1-3H3,(H,25,27)(H,26,29)/t20-,21+/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM185359
PNG
(US9670142, A117 6-(1H-indol-5-yl)-N-methyl-N-((1R,...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(nc1)-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C23H26N4O2/c1-3-22(28)26-18-6-7-19(13-18)27(2)23(29)17-5-9-21(25-14-17)15-4-8-20-16(12-15)10-11-24-20/h4-5,8-12,14,18-19,24H,3,6-7,13H2,1-2H3,(H,26,28)/t18-,19+/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM185520
PNG
(US9670142, A123 N-methyl-4-(1-methyl-1H-benzimidaz...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1nc2ccccc2n1C
Show InChI InChI=1S/C24H28N4O2/c1-4-22(29)25-18-13-14-19(15-18)27(2)24(30)17-11-9-16(10-12-17)23-26-20-7-5-6-8-21(20)28(23)3/h5-12,18-19H,4,13-15H2,1-3H3,(H,25,29)/t18-,19+/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM185563
PNG
(US9670142, A131 5-(1H-indol-5-yl)-pyrimidine-2-car...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ncc(cn1)-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C22H25N5O2/c1-3-20(28)26-17-5-6-18(11-17)27(2)22(29)21-24-12-16(13-25-21)14-4-7-19-15(10-14)8-9-23-19/h4,7-10,12-13,17-18,23H,3,5-6,11H2,1-2H3,(H,26,28)/t17-,18+/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM185569
PNG
(US9670142, A137 6-(4-fluoro-1H-indol-5-yl)-pyridaz...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(nn1)-c1ccc2[nH]ccc2c1F
Show InChI InChI=1S/C22H24FN5O2/c1-3-20(29)25-13-4-5-14(12-13)28(2)22(30)19-9-8-18(26-27-19)15-6-7-17-16(21(15)23)10-11-24-17/h6-11,13-14,24H,3-5,12H2,1-2H3,(H,25,29)/t13-,14+/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186330
PNG
(US9670142, A169 6-(3-fluoro-1H-indol-5-yl)-N-methy...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(nc1)-c1ccc2[nH]cc(F)c2c1
Show InChI InChI=1S/C23H25FN4O2/c1-3-22(29)27-16-6-7-17(11-16)28(2)23(30)15-5-8-20(25-12-15)14-4-9-21-18(10-14)19(24)13-26-21/h4-5,8-10,12-13,16-17,26H,3,6-7,11H2,1-2H3,(H,27,29)/t16-,17+/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186774
PNG
(US9670142, A171 7-fluoro-5-{4-[methyl-((1R,3S)-3-p...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1cc(F)c2[nH]cc(C(N)=O)c2c1
Show InChI InChI=1S/C25H27FN4O3/c1-3-22(31)29-17-8-9-18(12-17)30(2)25(33)15-6-4-14(5-7-15)16-10-19-20(24(27)32)13-28-23(19)21(26)11-16/h4-7,10-11,13,17-18,28H,3,8-9,12H2,1-2H3,(H2,27,32)(H,29,31)/t17-,18+/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186800
PNG
(US9670142, A174 (S)-tetrahydro-furan-2-carboxylic ...)
Show SMILES CN([C@@H]1CC[C@@H](C1)NC(=O)[C@@H]1CCCO1)C(=O)c1ccc(cc1)-c1nc2cc(Cl)ccc2o1
Show InChI InChI=1S/C25H26ClN3O4/c1-29(19-10-9-18(14-19)27-23(30)22-3-2-12-32-22)25(31)16-6-4-15(5-7-16)24-28-20-13-17(26)8-11-21(20)33-24/h4-8,11,13,18-19,22H,2-3,9-10,12,14H2,1H3,(H,27,30)/t18-,19+,22-/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183004
PNG
(US9670142, A33 4-benzoxazol-2-yl-N-[(1R,3S)-3-((S)...)
Show SMILES CO[C@@H](C)C(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C24H27N3O4/c1-15(30-3)22(28)25-18-12-13-19(14-18)27(2)24(29)17-10-8-16(9-11-17)23-26-20-6-4-5-7-21(20)31-23/h4-11,15,18-19H,12-14H2,1-3H3,(H,25,28)/t15-,18-,19+/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183005
PNG
(US9670142, A34 4-benzoxazol-2-yl-N-[(1R,3S)-3-(2-m...)
Show SMILES COCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C23H25N3O4/c1-26(18-12-11-17(13-18)24-21(27)14-29-2)23(28)16-9-7-15(8-10-16)22-25-19-5-3-4-6-20(19)30-22/h3-10,17-18H,11-14H2,1-2H3,(H,24,27)/t17-,18+/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183427
PNG
(US9670142, A44 4-benzoxazol-2-yl-N-[(1R,3S)-3-(2-c...)
Show SMILES CN([C@@H]1CC[C@@H](C1)NC(=O)CC1CCCC1)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C27H31N3O3/c1-30(22-15-14-21(17-22)28-25(31)16-18-6-2-3-7-18)27(32)20-12-10-19(11-13-20)26-29-23-8-4-5-9-24(23)33-26/h4-5,8-13,18,21-22H,2-3,6-7,14-17H2,1H3,(H,28,31)/t21-,22+/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183483
PNG
(US9670142, A58 4-benzo[1,3]dioxol-5-yl-N-methyl-N-...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc2OCOc2c1
Show InChI InChI=1S/C23H26N2O4/c1-3-22(26)24-18-9-10-19(13-18)25(2)23(27)16-6-4-15(5-7-16)17-8-11-20-21(12-17)29-14-28-20/h4-8,11-12,18-19H,3,9-10,13-14H2,1-2H3,(H,24,26)/t18-,19+/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183484
PNG
(US9670142, A59 4-benzothiazol-6-yl-N-methyl-N-((1R...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C23H25N3O2S/c1-3-22(27)25-18-9-10-19(13-18)26(2)23(28)16-6-4-15(5-7-16)17-8-11-20-21(12-17)29-14-24-20/h4-8,11-12,14,18-19H,3,9-10,13H2,1-2H3,(H,25,27)/t18-,19+/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183539
PNG
(US9670142, A67 4-(1H-indol-6-yl)-N-methyl-N-((1R,3...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc2cc[nH]c2c1
Show InChI InChI=1S/C24H27N3O2/c1-3-23(28)26-20-10-11-21(15-20)27(2)24(29)18-7-4-16(5-8-18)19-9-6-17-12-13-25-22(17)14-19/h4-9,12-14,20-21,25H,3,10-11,15H2,1-2H3,(H,26,28)/t20-,21+/m0/s1
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The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM182963
PNG
(US9670142, A25 4-benzoxazol-2-yl-N-methyl-N-[(1R,3...)
Show SMILES CN([C@@H]1CC[C@@H](C1)NC(=O)C(F)(F)C(F)(F)F)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C23H20F5N3O3/c1-31(16-11-10-15(12-16)29-21(33)22(24,25)23(26,27)28)20(32)14-8-6-13(7-9-14)19-30-17-4-2-3-5-18(17)34-19/h2-9,15-16H,10-12H2,1H3,(H,29,33)/t15-,16+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM185568
PNG
(US9670142, A136 6-(7-fluoro-1H-indol-5-yl)-pyridaz...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(nn1)-c1cc(F)c2[nH]ccc2c1
Show InChI InChI=1S/C22H24FN5O2/c1-3-20(29)25-15-4-5-16(12-15)28(2)22(30)19-7-6-18(26-27-19)14-10-13-8-9-24-21(13)17(23)11-14/h6-11,15-16,24H,3-5,12H2,1-2H3,(H,25,29)/t15-,16+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183066
PNG
(US9670142, A38 N-[(1R,3S)-3-(3-acetylamino-propion...)
Show SMILES CN([C@@H]1CC[C@@H](C1)NC(=O)CCNC(C)=O)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C25H28N4O4/c1-16(30)26-14-13-23(31)27-19-11-12-20(15-19)29(2)25(32)18-9-7-17(8-10-18)24-28-21-5-3-4-6-22(21)33-24/h3-10,19-20H,11-15H2,1-2H3,(H,26,30)(H,27,31)/t19-,20+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183509
PNG
(US9670142, A62 4'-trifluoromethoxy-biphenyl-4-...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C23H25F3N2O3/c1-3-21(29)27-18-10-11-19(14-18)28(2)22(30)17-6-4-15(5-7-17)16-8-12-20(13-9-16)31-23(24,25)26/h4-9,12-13,18-19H,3,10-11,14H2,1-2H3,(H,27,29)/t18-,19+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183464
PNG
(US9670142, A50 N-[(1R,3S)-3-(cyclopropanecarbonyl-...)
Show SMILES CN([C@@H]1CC[C@@H](C1)NC(=O)C1CC1)C(=O)c1ccc(cc1)-c1nc2cccc(F)c2o1
Show InChI InChI=1S/C24H24FN3O3/c1-28(18-12-11-17(13-18)26-22(29)14-5-6-14)24(30)16-9-7-15(8-10-16)23-27-20-4-2-3-19(25)21(20)31-23/h2-4,7-10,14,17-18H,5-6,11-13H2,1H3,(H,26,29)/t17-,18+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186091
PNG
(US9670142, A141 6-(7-fluoro-1H-indol-5-yl)-4,N-dim...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1cnc(cc1C)-c1cc(F)c2[nH]ccc2c1
Show InChI InChI=1S/C24H27FN4O2/c1-4-22(30)28-17-5-6-18(12-17)29(3)24(31)19-13-27-21(9-14(19)2)16-10-15-7-8-26-23(15)20(25)11-16/h7-11,13,17-18,26H,4-6,12H2,1-3H3,(H,28,30)/t17-,18+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


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More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM184027
PNG
(US9670142, A89 4'-(5-propyl-tetrahydro-pyran-2...)
Show SMILES CCCC1CCC(OC1)c1ccc(cc1)-c1ccc(cc1)C(=O)N(C)[C@@H]1CC[C@@H](C1)NC(=O)CC
Show InChI InChI=1S/C30H40N2O3/c1-4-6-21-7-18-28(35-20-21)24-12-8-22(9-13-24)23-10-14-25(15-11-23)30(34)32(3)27-17-16-26(19-27)31-29(33)5-2/h8-15,21,26-28H,4-7,16-20H2,1-3H3,(H,31,33)/t21?,26-,27+,28?/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186788
PNG
(US9670142, A172 7-fluoro-5-{2-fluoro-4-[methyl-((1...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(c(F)c1)-c1cc(F)c2[nH]cc(C(N)=O)c2c1
Show InChI InChI=1S/C25H26F2N4O3/c1-3-22(32)30-15-5-6-16(11-15)31(2)25(34)13-4-7-17(20(26)9-13)14-8-18-19(24(28)33)12-29-23(18)21(27)10-14/h4,7-10,12,15-16,29H,3,5-6,11H2,1-2H3,(H2,28,33)(H,30,32)/t15-,16+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183067
PNG
(US9670142, A39 (S)-2-acetylamino-N-{(1S,3R)-3-[(4-...)
Show SMILES COC(=O)[C@H](CC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1nc2ccccc2o1)NC(C)=O
Show InChI InChI=1S/C27H30N4O6/c1-16(32)28-22(27(35)36-3)15-24(33)29-19-12-13-20(14-19)31(2)26(34)18-10-8-17(9-11-18)25-30-21-6-4-5-7-23(21)37-25/h4-11,19-20,22H,12-15H2,1-3H3,(H,28,32)(H,29,33)/t19-,20+,22-/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183003
PNG
(US9670142, A32 4-benzoxazol-2-yl-N-[(1R,3S)-3-((R)...)
Show SMILES CO[C@H](C)C(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C24H27N3O4/c1-15(30-3)22(28)25-18-12-13-19(14-18)27(2)24(29)17-10-8-16(9-11-17)23-26-20-6-4-5-7-21(20)31-23/h4-11,15,18-19H,12-14H2,1-3H3,(H,25,28)/t15-,18+,19-/m1/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186317
PNG
(US9670142, A158 6-(6-chloro-1,3-benzoxazol-2-yl)-N...)
Show SMILES CN([C@@H]1CC[C@@H](C1)NC(=O)[C@@H]1CCCO1)C(=O)c1ccc(nn1)-c1nc2ccc(Cl)cc2o1
Show InChI InChI=1S/C23H24ClN5O4/c1-29(15-6-5-14(12-15)25-21(30)19-3-2-10-32-19)23(31)18-9-8-17(27-28-18)22-26-16-7-4-13(24)11-20(16)33-22/h4,7-9,11,14-15,19H,2-3,5-6,10,12H2,1H3,(H,25,30)/t14-,15+,19-/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186307
PNG
(US9670142, A148 5-(6-chloro-benzoxazol-2-yl)-pyraz...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1cnc(cn1)-c1nc2ccc(Cl)cc2o1
Show InChI InChI=1S/C21H22ClN5O3/c1-3-19(28)25-13-5-6-14(9-13)27(2)21(29)17-11-23-16(10-24-17)20-26-15-7-4-12(22)8-18(15)30-20/h4,7-8,10-11,13-14H,3,5-6,9H2,1-2H3,(H,25,28)/t13-,14+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186109
PNG
(US9670142, A145 6-(7-fluoro-2,3-dihydro-1H-indol-5...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(nc1)-c1cc2CCNc2c(F)c1
Show InChI InChI=1S/C23H27FN4O2/c1-3-21(29)27-17-5-6-18(12-17)28(2)23(30)15-4-7-20(26-13-15)16-10-14-8-9-25-22(14)19(24)11-16/h4,7,10-11,13,17-18,25H,3,5-6,8-9,12H2,1-2H3,(H,27,29)/t17-,18+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM185566
PNG
(US9670142, A134 6-(7-fluoro-1H-indol-5-yl)-N-methy...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(nc1)-c1cc(F)c2[nH]ccc2c1
Show InChI InChI=1S/C23H25FN4O2/c1-3-21(29)27-17-5-6-18(12-17)28(2)23(30)15-4-7-20(26-13-15)16-10-14-8-9-25-22(14)19(24)11-16/h4,7-11,13,17-18,25H,3,5-6,12H2,1-2H3,(H,27,29)/t17-,18+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM184490
PNG
(US9670142, A103 5-(6-methyl-1H-indazol-5-yl)-pyrid...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cn1)-c1cc2cn[nH]c2cc1C
Show InChI InChI=1S/C23H27N5O2/c1-4-22(29)26-17-6-7-18(11-17)28(3)23(30)20-8-5-15(12-24-20)19-10-16-13-25-27-21(16)9-14(19)2/h5,8-10,12-13,17-18H,4,6-7,11H2,1-3H3,(H,25,27)(H,26,29)/t17-,18+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186308
PNG
(US9670142, A149 5-(6-chloro-benzoxazol-2-yl)-pyrim...)
Show SMILES CN([C@@H]1CC[C@@H](C1)NC(=O)[C@@H]1CCCO1)C(=O)c1ncc(cn1)-c1nc2ccc(Cl)cc2o1
Show InChI InChI=1S/C23H24ClN5O4/c1-29(16-6-5-15(10-16)27-21(30)18-3-2-8-32-18)23(31)20-25-11-13(12-26-20)22-28-17-7-4-14(24)9-19(17)33-22/h4,7,9,11-12,15-16,18H,2-3,5-6,8,10H2,1H3,(H,27,30)/t15-,16+,18-/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183421
PNG
(US9670142, A43 N-[(1R,3S)-3-((S)-2-acetylamino-3-m...)
Show SMILES CC(C)[C@H](NC(C)=O)C(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C27H32N4O4/c1-16(2)24(28-17(3)32)25(33)29-20-13-14-21(15-20)31(4)27(34)19-11-9-18(10-12-19)26-30-22-7-5-6-8-23(22)35-26/h5-12,16,20-21,24H,13-15H2,1-4H3,(H,28,32)(H,29,33)/t20-,21+,24-/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186092
PNG
(US9670142, A142 5-fluoro-6-(7-fluoro-1H-indol-5-yl...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1cnc(c(F)c1)-c1cc(F)c2[nH]ccc2c1
Show InChI InChI=1S/C23H24F2N4O2/c1-3-20(30)28-16-4-5-17(11-16)29(2)23(31)15-10-19(25)22(27-12-15)14-8-13-6-7-26-21(13)18(24)9-14/h6-10,12,16-17,26H,3-5,11H2,1-2H3,(H,28,30)/t16-,17+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM182958
PNG
(US9670142, A20 4-benzoxazol-2-yl-N-((1R,3S)-3-benz...)
Show SMILES CN([C@@H]1CC[C@@H](C1)NC(=O)c1ccccc1)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C27H25N3O3/c1-30(22-16-15-21(17-22)28-25(31)18-7-3-2-4-8-18)27(32)20-13-11-19(12-14-20)26-29-23-9-5-6-10-24(23)33-26/h2-14,21-22H,15-17H2,1H3,(H,28,31)/t21-,22+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM184411
PNG
(US9670142, A96 4'-isopropyl-biphenyl-4-carboxy...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(cc1)C(C)C
Show InChI InChI=1S/C25H32N2O2/c1-5-24(28)26-22-14-15-23(16-22)27(4)25(29)21-12-10-20(11-13-21)19-8-6-18(7-9-19)17(2)3/h6-13,17,22-23H,5,14-16H2,1-4H3,(H,26,28)/t22-,23+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183473
PNG
(US9670142, A54 2'-fluoro-4'-(4-methyl-cycl...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(cc1F)C1CCC(C)CC1
Show InChI InChI=1S/C29H37FN2O2/c1-4-28(33)31-24-14-15-25(18-24)32(3)29(34)22-11-9-21(10-12-22)26-16-13-23(17-27(26)30)20-7-5-19(2)6-8-20/h9-13,16-17,19-20,24-25H,4-8,14-15,18H2,1-3H3,(H,31,33)/t19?,20?,24-,25+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183064
PNG
(US9670142, A36 4-benzoxazol-2-yl-N-[(1R,3S)-3-(2-d...)
Show SMILES CN(C)CC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C24H28N4O3/c1-27(2)15-22(29)25-18-12-13-19(14-18)28(3)24(30)17-10-8-16(9-11-17)23-26-20-6-4-5-7-21(20)31-23/h4-11,18-19H,12-15H2,1-3H3,(H,25,29)/t18-,19+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM182960
PNG
(US9670142, A22 N-{(1S,3R)-3-[(4-benzoxazol-2-yl-be...)
Show SMILES CN([C@@H]1CC[C@@H](C1)NC(=O)c1ccncc1)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C26H24N4O3/c1-30(21-11-10-20(16-21)28-24(31)17-12-14-27-15-13-17)26(32)19-8-6-18(7-9-19)25-29-22-4-2-3-5-23(22)33-25/h2-9,12-15,20-21H,10-11,16H2,1H3,(H,28,31)/t20-,21+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186325
PNG
(US9670142, A165 4-benzoxazol-2-yl-N-methyl-N-((1R,...)
Show SMILES CCC(=O)N[C@@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C23H25N3O3/c1-3-21(27)24-17-12-13-18(14-17)26(2)23(28)16-10-8-15(9-11-16)22-25-19-6-4-5-7-20(19)29-22/h4-11,17-18H,3,12-14H2,1-2H3,(H,24,27)/t17-,18-/m1/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186314
PNG
(US9670142, A155 6-(6-chloro-benzoxazol-2-yl)-pyrid...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(nn1)-c1nc2ccc(Cl)cc2o1
Show InChI InChI=1S/C21H22ClN5O3/c1-3-19(28)23-13-5-6-14(11-13)27(2)21(29)17-9-8-16(25-26-17)20-24-15-7-4-12(22)10-18(15)30-20/h4,7-10,13-14H,3,5-6,11H2,1-2H3,(H,23,28)/t13-,14+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186306
PNG
(US9670142, A147 6-(3,3-difluoro-2-oxo-2,3-dihydro-...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(nc1)-c1ccc2NC(=O)C(F)(F)c2c1
Show InChI InChI=1S/C23H24F2N4O3/c1-3-20(30)27-15-6-7-16(11-15)29(2)21(31)14-5-8-18(26-12-14)13-4-9-19-17(10-13)23(24,25)22(32)28-19/h4-5,8-10,12,15-16H,3,6-7,11H2,1-2H3,(H,27,30)(H,28,32)/t15-,16+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186328
PNG
(US9670142, A168 4-benzoxazol-2-yl-N-methyl-N-[(1R,...)
Show SMILES CC[C@@H](C)CC(=O)N[C@@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C26H31N3O3/c1-4-17(2)15-24(30)27-20-13-14-21(16-20)29(3)26(31)19-11-9-18(10-12-19)25-28-22-7-5-6-8-23(22)32-25/h5-12,17,20-21H,4,13-16H2,1-3H3,(H,27,30)/t17-,20-,21-/m1/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186326
PNG
(US9670142, A166 N-((1R,3R)-3-acetylamino-cyclopent...)
Show SMILES CN([C@@H]1CC[C@H](C1)NC(C)=O)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C22H23N3O3/c1-14(26)23-17-11-12-18(13-17)25(2)22(27)16-9-7-15(8-10-16)21-24-19-5-3-4-6-20(19)28-21/h3-10,17-18H,11-13H2,1-2H3,(H,23,26)/t17-,18-/m1/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186315
PNG
(US9670142, A156 5-(6-chloro-benzoxazol-2-yl)-pyrim...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ncc(cn1)-c1nc2ccc(Cl)cc2o1
Show InChI InChI=1S/C21H22ClN5O3/c1-3-18(28)25-14-5-6-15(9-14)27(2)21(29)19-23-10-12(11-24-19)20-26-16-7-4-13(22)8-17(16)30-20/h4,7-8,10-11,14-15H,3,5-6,9H2,1-2H3,(H,25,28)/t14-,15+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183504
PNG
(US9670142, A61 4'-cyano-3',5'-difluoro...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1cc(F)c(C#N)c(F)c1
Show InChI InChI=1S/C23H23F2N3O2/c1-3-22(29)27-17-8-9-18(12-17)28(2)23(30)15-6-4-14(5-7-15)16-10-20(24)19(13-26)21(25)11-16/h4-7,10-11,17-18H,3,8-9,12H2,1-2H3,(H,27,29)/t17-,18+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183475
PNG
(US9670142, A55 tert-butyl-biphenyl-4-carboxylic ac...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C26H34N2O2/c1-6-24(29)27-22-15-16-23(17-22)28(5)25(30)20-9-7-18(8-10-20)19-11-13-21(14-12-19)26(2,3)4/h7-14,22-23H,6,15-17H2,1-5H3,(H,27,29)/t22-,23+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM186327
PNG
(US9670142, A167 4-benzoxazol-2-yl-N-methyl-N-((1R,...)
Show SMILES CN([C@@H]1CC[C@H](C1)NC(=O)Cc1ccccc1)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C28H27N3O3/c1-31(23-16-15-22(18-23)29-26(32)17-19-7-3-2-4-8-19)28(33)21-13-11-20(12-14-21)27-30-24-9-5-6-10-25(24)34-27/h2-14,22-23H,15-18H2,1H3,(H,29,32)/t22-,23-/m1/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183459
PNG
(US9670142, A48 N-[(1R,3S)-3-((R)-2-acetylamino-pro...)
Show SMILES CC(C)N[C@H](C)C(=O)N[C@H]1CCC(C1)N(C)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C26H32N4O3/c1-16(2)27-17(3)24(31)28-20-13-14-21(15-20)30(4)26(32)19-11-9-18(10-12-19)25-29-22-7-5-6-8-23(22)33-25/h5-12,16-17,20-21,27H,13-15H2,1-4H3,(H,28,31)/t17-,20+,21?/m1/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183437
PNG
(US9670142, A45 4-benzoxazol-2-yl-N-methyl-N-{(1R,3...)
Show SMILES CN(C1CC[C@@H](C1)NC(=O)C[C@@H]1CCC(=O)N1)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C26H28N4O4/c1-30(20-12-10-18(14-20)28-24(32)15-19-11-13-23(31)27-19)26(33)17-8-6-16(7-9-17)25-29-21-4-2-3-5-22(21)34-25/h2-9,18-20H,10-15H2,1H3,(H,27,31)(H,28,32)/t18-,19-,20?/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183416
PNG
(US9670142, A42 N-[(1R,3S)-3-((R)-2-acetylamino-3-m...)
Show SMILES CC(C)[C@@H](NC(C)=O)C(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C27H32N4O4/c1-16(2)24(28-17(3)32)25(33)29-20-13-14-21(15-20)31(4)27(34)19-11-9-18(10-12-19)26-30-22-7-5-6-8-23(22)35-26/h5-12,16,20-21,24H,13-15H2,1-4H3,(H,28,32)(H,29,33)/t20-,21+,24+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM183447
PNG
(US9670142, A47 N-[(1R,3S)-3-((S)-2-acetylamino-pro...)
Show SMILES C[C@H](NC(C)=O)C(=O)N[C@H]1CCC(C1)N(C)C(=O)c1ccc(cc1)-c1nc2ccccc2o1
Show InChI InChI=1S/C25H28N4O4/c1-15(26-16(2)30)23(31)27-19-12-13-20(14-19)29(3)25(32)18-10-8-17(9-11-18)24-28-21-6-4-5-7-22(21)33-24/h4-11,15,19-20H,12-14H2,1-3H3,(H,26,30)(H,27,31)/t15-,19-,20?/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM182949
PNG
(US9670142, A11 4-(1H-imidazol-2-yl)-N-methyl-N-((1...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ncc[nH]1
Show InChI InChI=1S/C19H24N4O2/c1-3-17(24)22-15-8-9-16(12-15)23(2)19(25)14-6-4-13(5-7-14)18-20-10-11-21-18/h4-7,10-11,15-16H,3,8-9,12H2,1-2H3,(H,20,21)(H,22,24)/t15-,16+/m0/s1
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Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%