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Patent code US9670191

Compile Data Set for Download or QSAR
Found 116 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329414
PNG
(2-(4-Methoxy-phenyl)-5-pyridin-4-yl-1H-pyrrole-3-c...)
Show SMILES COc1ccc(cc1)-c1[nH]c(cc1C(N)=O)-c1ccncc1
Show InChI InChI=1S/C17H15N3O2/c1-22-13-4-2-12(3-5-13)16-14(17(18)21)10-15(20-16)11-6-8-19-9-7-11/h2-10,20H,1H3,(H2,18,21)
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n/an/a<100n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329467
PNG
(2-(4-Bromo-phenyl)-5-pyridin-4-yl-1H-pyrrole-3-car...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccc(Br)cc1)-c1ccncc1
Show InChI InChI=1S/C16H12BrN3O/c17-12-3-1-11(2-4-12)15-13(16(18)21)9-14(20-15)10-5-7-19-8-6-10/h1-9,20H,(H2,18,21)
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n/an/a<100n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329415
PNG
(2-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-pyrrole-3-ca...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C16H12FN3O/c17-12-3-1-11(2-4-12)15-13(16(18)21)9-14(20-15)10-5-7-19-8-6-10/h1-9,20H,(H2,18,21)
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n/an/a<100n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329428
PNG
(2-(2-Methoxy-phenyl)-5-pyridin-4-yl-1H-pyrrole-3-c...)
Show SMILES COc1ccccc1-c1[nH]c(cc1C(N)=O)-c1ccncc1
Show InChI InChI=1S/C17H15N3O2/c1-22-15-5-3-2-4-12(15)16-13(17(18)21)10-14(20-16)11-6-8-19-9-7-11/h2-10,20H,1H3,(H2,18,21)
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n/an/a<100n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329430
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-thiophen-3-yl-1H-pyrr...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccsc1)-c1ccnc(N)n1
Show InChI InChI=1S/C13H11N5OS/c14-12(19)8-5-10(9-1-3-16-13(15)18-9)17-11(8)7-2-4-20-6-7/h1-6,17H,(H2,14,19)(H2,15,16,18)
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n/an/a<100n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329436
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-c...)
Show SMILES CC(C)NC(=O)c1cc([nH]c1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C18H19N5O/c1-11(2)21-17(24)13-10-15(14-8-9-20-18(19)23-14)22-16(13)12-6-4-3-5-7-12/h3-11,22H,1-2H3,(H,21,24)(H2,19,20,23)
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n/an/a<100n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329418
PNG
(2-Phenyl-5-pyridin-4-yl-1H-pyrrole-3-carboxamide |...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C16H13N3O/c17-16(20)13-10-14(11-6-8-18-9-7-11)19-15(13)12-4-2-1-3-5-12/h1-10,19H,(H2,17,20)
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n/an/a<100n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329416
PNG
(2-(2-Fluoro-phenyl)-5-pyridin-4-yl-1H-pyrrole-3-ca...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1F)-c1ccncc1
Show InChI InChI=1S/C16H12FN3O/c17-13-4-2-1-3-11(13)15-12(16(18)21)9-14(20-15)10-5-7-19-8-6-10/h1-9,20H,(H2,18,21)
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n/an/a<100n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329425
PNG
(2-(3-Fluoro-phenyl)-5-pyridin-4-yl-1H-pyrrole-3-ca...)
Show SMILES NC(=O)c1cc([nH]c1-c1cccc(F)c1)-c1ccncc1
Show InChI InChI=1S/C16H12FN3O/c17-12-3-1-2-11(8-12)15-13(16(18)21)9-14(20-15)10-4-6-19-7-5-10/h1-9,20H,(H2,18,21)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329449
PNG
(5-Pyridin-4-yl-2-m-tolyl-1H-pyrrole-3-carboxamide ...)
Show SMILES Cc1cccc(c1)-c1[nH]c(cc1C(N)=O)-c1ccncc1
Show InChI InChI=1S/C17H15N3O/c1-11-3-2-4-13(9-11)16-14(17(18)21)10-15(20-16)12-5-7-19-8-6-12/h2-10,20H,1H3,(H2,18,21)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329465
PNG
(2-(3-Methoxy-phenyl)-5-pyridin-4-yl-1H-pyrrole-3-c...)
Show SMILES COc1cccc(c1)-c1[nH]c(cc1C(N)=O)-c1ccncc1
Show InChI InChI=1S/C17H15N3O2/c1-22-13-4-2-3-12(9-13)16-14(17(18)21)10-15(20-16)11-5-7-19-8-6-11/h2-10,20H,1H3,(H2,18,21)
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n/an/a<100n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329463
PNG
(2-Phenyl-5-(2-phenylamino-pyrimidin-4-yl)-1H-pyrro...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1)-c1ccnc(Nc2ccccc2)n1
Show InChI InChI=1S/C21H17N5O/c22-20(27)16-13-18(25-19(16)14-7-3-1-4-8-14)17-11-12-23-21(26-17)24-15-9-5-2-6-10-15/h1-13,25H,(H2,22,27)(H,23,24,26)
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n/an/a<100n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187216
PNG
(US9670191, A7)
Show SMILES Cc1ccccc1-c1[nH]c(cc1C(N)=O)-c1ccncc1
Show InChI InChI=1S/C17H15N3O/c1-11-4-2-3-5-13(11)16-14(17(18)21)10-15(20-16)12-6-8-19-9-7-12/h2-10,20H,1H3,(H2,18,21)
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n/an/a<100n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329431
PNG
(5-Pyridin-4-yl-2-p-tolyl-1H-pyrrole-3-carboxamide ...)
Show SMILES Cc1ccc(cc1)-c1[nH]c(cc1C(N)=O)-c1ccncc1
Show InChI InChI=1S/C17H15N3O/c1-11-2-4-13(5-3-11)16-14(17(18)21)10-15(20-16)12-6-8-19-9-7-12/h2-10,20H,1H3,(H2,18,21)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187240
PNG
(US9670191, C1)
Show SMILES NC(=O)c1cc([nH]c1-c1ccsc1)-c1ccncc1
Show InChI InChI=1S/C14H11N3OS/c15-14(18)11-7-12(9-1-4-16-5-2-9)17-13(11)10-3-6-19-8-10/h1-8,17H,(H2,15,18)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187241
PNG
(US9670191, C2)
Show SMILES NC(=O)c1cc([nH]c1-c1ccoc1)-c1ccncc1
Show InChI InChI=1S/C14H11N3O2/c15-14(18)11-7-12(9-1-4-16-5-2-9)17-13(11)10-3-6-19-8-10/h1-8,17H,(H2,15,18)
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n/an/a<100n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329417
PNG
(5-(3-Fluoro-pyridin-4-yl)-2-phenyl-1H-pyrrole-3-ca...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1)-c1ccncc1F
Show InChI InChI=1S/C16H12FN3O/c17-13-9-19-7-6-11(13)14-8-12(16(18)21)15(20-14)10-4-2-1-3-5-10/h1-9,20H,(H2,18,21)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329422
PNG
(5-(2-Amino-pyrimidin-4-yl)-1-ethyl-2-phenyl-1H-pyr...)
Show SMILES CCn1c(cc(C(N)=O)c1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C17H17N5O/c1-2-22-14(13-8-9-20-17(19)21-13)10-12(16(18)23)15(22)11-6-4-3-5-7-11/h3-10H,2H2,1H3,(H2,18,23)(H2,19,20,21)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329435
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-c...)
Show SMILES Nc1nccc(n1)-c1cc(C(=O)NCc2ccccc2)c([nH]1)-c1ccccc1
Show InChI InChI=1S/C22H19N5O/c23-22-24-12-11-18(27-22)19-13-17(20(26-19)16-9-5-2-6-10-16)21(28)25-14-15-7-3-1-4-8-15/h1-13,26H,14H2,(H,25,28)(H2,23,24,27)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329427
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-c...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C15H13N5O/c16-14(21)10-8-12(11-6-7-18-15(17)20-11)19-13(10)9-4-2-1-3-5-9/h1-8,19H,(H2,16,21)(H2,17,18,20)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187229
PNG
(US9670191, A20)
Show SMILES Cc1cccc(-c2[nH]c(cc2C(N)=O)-c2ccncc2)c1C
Show InChI InChI=1S/C18H17N3O/c1-11-4-3-5-14(12(11)2)17-15(18(19)22)10-16(21-17)13-6-8-20-9-7-13/h3-10,21H,1-2H3,(H2,19,22)
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n/an/a<100n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329470
PNG
(2-(3-Bromo-phenyl)-5-pyridin-4-yl-1H-pyrrole-3-car...)
Show SMILES NC(=O)c1cc([nH]c1-c1cccc(Br)c1)-c1ccncc1
Show InChI InChI=1S/C16H12BrN3O/c17-12-3-1-2-11(8-12)15-13(16(18)21)9-14(20-15)10-4-6-19-7-5-10/h1-9,20H,(H2,18,21)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187800
PNG
(US9670191, M4)
Show SMILES Nc1nccc(n1)-c1cc(C(=O)NCC2CCCCC2)c([nH]1)-c1ccccc1
Show InChI InChI=1S/C22H25N5O/c23-22-24-12-11-18(27-22)19-13-17(20(26-19)16-9-5-2-6-10-16)21(28)25-14-15-7-3-1-4-8-15/h2,5-6,9-13,15,26H,1,3-4,7-8,14H2,(H,25,28)(H2,23,24,27)
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n/an/a<100n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329471
PNG
(2-(2-Nitro-phenyl)-5-pyridin-4-yl-1H-pyrrole-3-car...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1[N+]([O-])=O)-c1ccncc1
Show InChI InChI=1S/C16H12N4O3/c17-16(21)12-9-13(10-5-7-18-8-6-10)19-15(12)11-3-1-2-4-14(11)20(22)23/h1-9,19H,(H2,17,21)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187225
PNG
(US9670191, A16)
Show SMILES CC(=O)c1cccc(c1)-c1[nH]c(cc1C(N)=O)-c1ccncc1
Show InChI InChI=1S/C18H15N3O2/c1-11(22)13-3-2-4-14(9-13)17-15(18(19)23)10-16(21-17)12-5-7-20-8-6-12/h2-10,21H,1H3,(H2,19,23)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187226
PNG
(US9670191, A17)
Show SMILES NC(=O)c1cc([nH]c1-c1cccc(CO)c1)-c1ccncc1
Show InChI InChI=1S/C17H15N3O2/c18-17(22)14-9-15(12-4-6-19-7-5-12)20-16(14)13-3-1-2-11(8-13)10-21/h1-9,20-21H,10H2,(H2,18,22)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187228
PNG
(US9670191, A19)
Show SMILES Cc1ccc(C)c(c1)-c1[nH]c(cc1C(N)=O)-c1ccncc1
Show InChI InChI=1S/C18H17N3O/c1-11-3-4-12(2)14(9-11)17-15(18(19)22)10-16(21-17)13-5-7-20-8-6-13/h3-10,21H,1-2H3,(H2,19,22)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187400
PNG
(US9670191, F7)
Show SMILES NC(=O)c1cc([nH]c1-c1ccc(Oc2ccccc2)cc1)-c1ccnc(N)n1
Show InChI InChI=1S/C21H17N5O2/c22-20(27)16-12-18(17-10-11-24-21(23)26-17)25-19(16)13-6-8-15(9-7-13)28-14-4-2-1-3-5-14/h1-12,25H,(H2,22,27)(H2,23,24,26)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187556
PNG
(US9670191, F31)
Show SMILES NC(=O)c1cc([nH]c1-c1cc(F)ccc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C15H11ClFN5O/c16-10-2-1-7(17)5-8(10)13-9(14(18)23)6-12(21-13)11-3-4-20-15(19)22-11/h1-6,21H,(H2,18,23)(H2,19,20,22)
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NERVIANO MEDICAL SCIENCES S.R.L.

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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187560
PNG
(US9670191, F34)
Show SMILES NC(=O)c1cc([nH]c1-c1cccc(Cl)c1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C15H11Cl2N5O/c16-9-3-1-2-7(12(9)17)13-8(14(18)23)6-11(21-13)10-4-5-20-15(19)22-10/h1-6,21H,(H2,18,23)(H2,19,20,22)
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NERVIANO MEDICAL SCIENCES S.R.L.

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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329433
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-thiophen-2-yl-1H-pyrr...)
Show SMILES NC(=O)c1cc([nH]c1-c1cccs1)-c1ccnc(N)n1
Show InChI InChI=1S/C13H11N5OS/c14-12(19)7-6-9(8-3-4-16-13(15)18-8)17-11(7)10-2-1-5-20-10/h1-6,17H,(H2,14,19)(H2,15,16,18)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329462
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-benzo[b]thiophen-2-yl...)
Show SMILES NC(=O)c1cc([nH]c1-c1cc2ccccc2s1)-c1ccnc(N)n1
Show InChI InChI=1S/C17H13N5OS/c18-16(23)10-8-12(11-5-6-20-17(19)22-11)21-15(10)14-7-9-3-1-2-4-13(9)24-14/h1-8,21H,(H2,18,23)(H2,19,20,22)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187980
PNG
(US9670191, N7)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1F)-c1nc(N)ncc1Cl
Show InChI InChI=1S/C15H11ClFN5O/c16-9-6-20-15(19)22-13(9)11-5-8(14(18)23)12(21-11)7-3-1-2-4-10(7)17/h1-6,21H,(H2,18,23)(H2,19,20,22)
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NERVIANO MEDICAL SCIENCES S.R.L.

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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329438
PNG
(2-Piperidin-4-yl-5-pyridin-4-yl-1H-pyrrole-3-carbo...)
Show SMILES NC(=O)c1cc([nH]c1C1CCNCC1)-c1ccncc1
Show InChI InChI=1S/C15H18N4O/c16-15(20)12-9-13(10-1-5-17-6-2-10)19-14(12)11-3-7-18-8-4-11/h1-2,5-6,9,11,18-19H,3-4,7-8H2,(H2,16,20)
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NERVIANO MEDICAL SCIENCES S.R.L.

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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329423
PNG
(2-(3-Nitro-phenyl)-5-pyridin-4-yl-1H-pyrrole-3-car...)
Show SMILES NC(=O)c1cc([nH]c1-c1cccc(c1)[N+]([O-])=O)-c1ccncc1
Show InChI InChI=1S/C16H12N4O3/c17-16(21)13-9-14(10-4-6-18-7-5-10)19-15(13)11-2-1-3-12(8-11)20(22)23/h1-9,19H,(H2,17,21)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187230
PNG
(US9670191, A21)
Show SMILES Cc1ccc(cc1C)-c1[nH]c(cc1C(N)=O)-c1ccncc1
Show InChI InChI=1S/C18H17N3O/c1-11-3-4-14(9-12(11)2)17-15(18(19)22)10-16(21-17)13-5-7-20-8-6-13/h3-10,21H,1-2H3,(H2,19,22)
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NERVIANO MEDICAL SCIENCES S.R.L.

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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187231
PNG
(US9670191, A22)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1[N+]#[C-])-c1ccncc1
Show InChI InChI=1S/C17H12N4O/c1-19-14-5-3-2-4-12(14)16-13(17(18)22)10-15(21-16)11-6-8-20-9-7-11/h2-10,21H,(H2,18,22)
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NERVIANO MEDICAL SCIENCES S.R.L.

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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329434
PNG
(2,5-Dipyridin-4-yl-1H-pyrrole-3-carboxamide | CHEM...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccncc1)-c1ccncc1
Show InChI InChI=1S/C15H12N4O/c16-15(20)12-9-13(10-1-5-17-6-2-10)19-14(12)11-3-7-18-8-4-11/h1-9,19H,(H2,16,20)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187247
PNG
(US9670191, F2)
Show SMILES Cc1ccccc1-c1[nH]c(cc1C(N)=O)-c1ccnc(N)n1
Show InChI InChI=1S/C16H15N5O/c1-9-4-2-3-5-10(9)14-11(15(17)22)8-13(20-14)12-6-7-19-16(18)21-12/h2-8,20H,1H3,(H2,17,22)(H2,18,19,21)
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NERVIANO MEDICAL SCIENCES S.R.L.

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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187542
PNG
(US9670191, F24)
Show SMILES Cc1ccc(C)c(c1)-c1[nH]c(cc1C(N)=O)-c1ccnc(N)n1
Show InChI InChI=1S/C17H17N5O/c1-9-3-4-10(2)11(7-9)15-12(16(18)23)8-14(21-15)13-5-6-20-17(19)22-13/h3-8,21H,1-2H3,(H2,18,23)(H2,19,20,22)
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NERVIANO MEDICAL SCIENCES S.R.L.

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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187548
PNG
(US9670191, F27)
Show SMILES NC(=O)c1cc([nH]c1-c1cc(Cl)ccc1F)-c1ccnc(N)n1
Show InChI InChI=1S/C15H11ClFN5O/c16-7-1-2-10(17)8(5-7)13-9(14(18)23)6-12(21-13)11-3-4-20-15(19)22-11/h1-6,21H,(H2,18,23)(H2,19,20,22)
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NERVIANO MEDICAL SCIENCES S.R.L.

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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187557
PNG
(US9670191, F32)
Show SMILES Cc1cc(Cl)cc(-c2[nH]c(cc2C(N)=O)-c2ccnc(N)n2)c1F
Show InChI InChI=1S/C16H13ClFN5O/c1-7-4-8(17)5-9(13(7)18)14-10(15(19)24)6-12(22-14)11-2-3-21-16(20)23-11/h2-6,22H,1H3,(H2,19,24)(H2,20,21,23)
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NERVIANO MEDICAL SCIENCES S.R.L.

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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329466
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-benzo[b]thiophen-3-yl...)
Show SMILES NC(=O)c1cc([nH]c1-c1csc2ccccc12)-c1ccnc(N)n1
Show InChI InChI=1S/C17H13N5OS/c18-16(23)10-7-13(12-5-6-20-17(19)22-12)21-15(10)11-8-24-14-4-2-1-3-9(11)14/h1-8,21H,(H2,18,23)(H2,19,20,22)
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NERVIANO MEDICAL SCIENCES S.R.L.

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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329444
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-pyridin-2-yl-1H-pyrro...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccn1)-c1ccnc(N)n1
Show InChI InChI=1S/C14H12N6O/c15-13(21)8-7-11(9-4-6-18-14(16)20-9)19-12(8)10-3-1-2-5-17-10/h1-7,19H,(H2,15,21)(H2,16,18,20)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329437
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-c...)
Show SMILES CNC(=O)c1cc([nH]c1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C16H15N5O/c1-18-15(22)11-9-13(12-7-8-19-16(17)21-12)20-14(11)10-5-3-2-4-6-10/h2-9,20H,1H3,(H,18,22)(H2,17,19,21)
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NERVIANO MEDICAL SCIENCES S.R.L.

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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187979
PNG
(US9670191, N6)
Show SMILES NC(=O)c1c(I)c([nH]c1-c1ccccc1)-c1nc(N)ncc1Br
Show InChI InChI=1S/C15H11BrIN5O/c16-8-6-20-15(19)22-12(8)13-10(17)9(14(18)23)11(21-13)7-4-2-1-3-5-7/h1-6,21H,(H2,18,23)(H2,19,20,22)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329441
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-phenyl-4-vinyl-1H-pyr...)
Show SMILES NC(=O)c1c(C=C)c([nH]c1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C17H15N5O/c1-2-11-13(16(18)23)14(10-6-4-3-5-7-10)22-15(11)12-8-9-20-17(19)21-12/h2-9,22H,1H2,(H2,18,23)(H2,19,20,21)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329439
PNG
(4-(3-Carbamoyl-5-pyridin-4-yl-1H-pyrrol-2-yl)-pipe...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)c1[nH]c(cc1C(N)=O)-c1ccncc1
Show InChI InChI=1S/C20H26N4O3/c1-20(2,3)27-19(26)24-10-6-14(7-11-24)17-15(18(21)25)12-16(23-17)13-4-8-22-9-5-13/h4-5,8-9,12,14,23H,6-7,10-11H2,1-3H3,(H2,21,25)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329446
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-phenyl-furan-3-carbox...)
Show SMILES NC(=O)c1cc(oc1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C15H12N4O2/c16-14(20)10-8-12(11-6-7-18-15(17)19-11)21-13(10)9-4-2-1-3-5-9/h1-8H,(H2,16,20)(H2,17,18,19)
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NERVIANO MEDICAL SCIENCES S.R.L.

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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187235
PNG
(US9670191, A26)
Show SMILES NC(=O)c1cc([nH]c1-c1ccc(cc1)N1CCOCC1)-c1ccncc1
Show InChI InChI=1S/C20H20N4O2/c21-20(25)17-13-18(14-5-7-22-8-6-14)23-19(17)15-1-3-16(4-2-15)24-9-11-26-12-10-24/h1-8,13,23H,9-12H2,(H2,21,25)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187237
PNG
(US9670191, A28)
Show SMILES NC(=O)c1cc([nH]c1-c1ccc2CCNCc2c1)-c1ccncc1
Show InChI InChI=1S/C19H18N4O/c20-19(24)16-10-17(13-4-6-21-7-5-13)23-18(16)14-2-1-12-3-8-22-11-15(12)9-14/h1-2,4-7,9-10,22-23H,3,8,11H2,(H2,20,24)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187245
PNG
(US9670191, E2)
Show SMILES Cc1ccccc1-c1[nH]c(cc1C(N)=O)-c1ccncc1F
Show InChI InChI=1S/C17H14FN3O/c1-10-4-2-3-5-11(10)16-13(17(19)22)8-15(21-16)12-6-7-20-9-14(12)18/h2-9,21H,1H3,(H2,19,22)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187249
PNG
(US9670191, F4)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1F)-c1ccnc(N)n1
Show InChI InChI=1S/C15H12FN5O/c16-10-4-2-1-3-8(10)13-9(14(17)22)7-12(20-13)11-5-6-19-15(18)21-11/h1-7,20H,(H2,17,22)(H2,18,19,21)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329448
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-naphthalen-2-yl-1H-py...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccc2ccccc2c1)-c1ccnc(N)n1
Show InChI InChI=1S/C19H15N5O/c20-18(25)14-10-16(15-7-8-22-19(21)24-15)23-17(14)13-6-5-11-3-1-2-4-12(11)9-13/h1-10,23H,(H2,20,25)(H2,21,22,24)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187525
PNG
(US9670191, F19)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C15H12ClN5O/c16-10-4-2-1-3-8(10)13-9(14(17)22)7-12(20-13)11-5-6-19-15(18)21-11/h1-7,20H,(H2,17,22)(H2,18,19,21)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187561
PNG
(US9670191, F35)
Show SMILES COc1cccc(-c2[nH]c(cc2C(N)=O)-c2ccnc(N)n2)c1F
Show InChI InChI=1S/C16H14FN5O2/c1-24-12-4-2-3-8(13(12)17)14-9(15(18)23)7-11(21-14)10-5-6-20-16(19)22-10/h2-7,21H,1H3,(H2,18,23)(H2,19,20,22)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187567
PNG
(US9670191, G3)
Show SMILES Cc1ccc(s1)-c1[nH]c(cc1C(N)=O)-c1ccnc(N)n1
Show InChI InChI=1S/C14H13N5OS/c1-7-2-3-11(21-7)12-8(13(15)20)6-10(18-12)9-4-5-17-14(16)19-9/h2-6,18H,1H3,(H2,15,20)(H2,16,17,19)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329464
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-(1-methyl-1H-indol-2-...)
Show SMILES Cn1c(cc2ccccc12)-c1[nH]c(cc1C(N)=O)-c1ccnc(N)n1
Show InChI InChI=1S/C18H16N6O/c1-24-14-5-3-2-4-10(14)8-15(24)16-11(17(19)25)9-13(22-16)12-6-7-21-18(20)23-12/h2-9,22H,1H3,(H2,19,25)(H2,20,21,23)
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US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329419
PNG
(5-(2-amino-5-bromopyrimidin-4-yl)-2-p-tolyl-1H-pyr...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1)-c1nc(N)ncc1Br
Show InChI InChI=1S/C15H12BrN5O/c16-10-7-19-15(18)21-13(10)11-6-9(14(17)22)12(20-11)8-4-2-1-3-5-8/h1-7,20H,(H2,17,22)(H2,18,19,21)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329472
PNG
(5-(2-amino-pyrimidin-4-yl)-4-iodo-2-phenyl-1H-pyrr...)
Show SMILES NC(=O)c1c(I)c([nH]c1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C15H12IN5O/c16-11-10(14(17)22)12(8-4-2-1-3-5-8)21-13(11)9-6-7-19-15(18)20-9/h1-7,21H,(H2,17,22)(H2,18,19,20)
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NERVIANO MEDICAL SCIENCES S.R.L.

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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329457
PNG
(2-Cyclohexyl-5-pyridin-4-yl-1H-pyrrole-3-carboxami...)
Show SMILES NC(=O)c1cc([nH]c1C1CCCCC1)-c1ccncc1
Show InChI InChI=1S/C16H19N3O/c17-16(20)13-10-14(11-6-8-18-9-7-11)19-15(13)12-4-2-1-3-5-12/h6-10,12,19H,1-5H2,(H2,17,20)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM188073
PNG
(US9670191, R2)
Show SMILES NC(=O)c1cc([nH]c1Br)-c1ccnc(N)n1
Show InChI InChI=1S/C9H8BrN5O/c10-7-4(8(11)16)3-6(14-7)5-1-2-13-9(12)15-5/h1-3,14H,(H2,11,16)(H2,12,13,15)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187239
PNG
(US9670191, B1)
Show SMILES Cc1c([nH]c(c1C(N)=O)-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C17H15N3O/c1-11-14(17(18)21)16(12-5-3-2-4-6-12)20-15(11)13-7-9-19-10-8-13/h2-10,20H,1H3,(H2,18,21)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187517
PNG
(US9670191, F13)
Show SMILES Cc1cc(F)ccc1-c1[nH]c(cc1C(N)=O)-c1ccnc(N)n1
Show InChI InChI=1S/C16H14FN5O/c1-8-6-9(17)2-3-10(8)14-11(15(18)23)7-13(21-14)12-4-5-20-16(19)22-12/h2-7,21H,1H3,(H2,18,23)(H2,19,20,22)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187521
PNG
(US9670191, F16)
Show SMILES NC(=O)c1cc([nH]c1-c1cccc(F)c1F)-c1ccnc(N)n1
Show InChI InChI=1S/C15H11F2N5O/c16-9-3-1-2-7(12(9)17)13-8(14(18)23)6-11(21-13)10-4-5-20-15(19)22-10/h1-6,21H,(H2,18,23)(H2,19,20,22)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187528
PNG
(US9670191, F21)
Show SMILES NC(=O)c1cc([nH]c1-c1ccc(Cl)cc1)-c1ccnc(N)n1
Show InChI InChI=1S/C15H12ClN5O/c16-9-3-1-8(2-4-9)13-10(14(17)22)7-12(20-13)11-5-6-19-15(18)21-11/h1-7,20H,(H2,17,22)(H2,18,19,21)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187529
PNG
(US9670191, F22)
Show SMILES CC(C)Cc1ccc(cc1)-c1[nH]c(cc1C(N)=O)-c1ccnc(N)n1
Show InChI InChI=1S/C19H21N5O/c1-11(2)9-12-3-5-13(6-4-12)17-14(18(20)25)10-16(23-17)15-7-8-22-19(21)24-15/h3-8,10-11,23H,9H2,1-2H3,(H2,20,25)(H2,21,22,24)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50439561
PNG
(CHEMBL1965660 | US9670191, F26)
Show SMILES NC(=O)c1cc([nH]c1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C15H11Cl2N5O/c16-7-1-2-8(10(17)5-7)13-9(14(18)23)6-12(21-13)11-3-4-20-15(19)22-11/h1-6,21H,(H2,18,23)(H2,19,20,22)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187558
PNG
(US9670191, F33)
Show SMILES NC(=O)c1cc([nH]c1-c1cccc(Cl)c1F)-c1ccnc(N)n1
Show InChI InChI=1S/C15H11ClFN5O/c16-9-3-1-2-7(12(9)17)13-8(14(18)23)6-11(21-13)10-4-5-20-15(19)22-10/h1-6,21H,(H2,18,23)(H2,19,20,22)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187801
PNG
(US9670191, M5)
Show SMILES Nc1nccc(n1)-c1cc(C(=O)NCCc2ccccc2)c([nH]1)-c1ccccc1
Show InChI InChI=1S/C23H21N5O/c24-23-26-14-12-19(28-23)20-15-18(21(27-20)17-9-5-2-6-10-17)22(29)25-13-11-16-7-3-1-4-8-16/h1-10,12,14-15,27H,11,13H2,(H,25,29)(H2,24,26,28)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187981
PNG
(US9670191, N8)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1F)-c1nc(N)ncc1Br
Show InChI InChI=1S/C15H11BrFN5O/c16-9-6-20-15(19)22-13(9)11-5-8(14(18)23)12(21-11)7-3-1-2-4-10(7)17/h1-6,21H,(H2,18,23)(H2,19,20,22)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329426
PNG
(5-(2-Amino-5-fluoro-pyrimidin-4-yl)-2-phenyl-1H-py...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1)-c1nc(N)ncc1F
Show InChI InChI=1S/C15H12FN5O/c16-10-7-19-15(18)21-13(10)11-6-9(14(17)22)12(20-11)8-4-2-1-3-5-8/h1-7,20H,(H2,17,22)(H2,18,19,21)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329424
PNG
(5-(2-aminopyrimidin-4-yl)-4-chloro-2-phenyl-1H-pyr...)
Show SMILES NC(=O)c1c(Cl)c([nH]c1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C15H12ClN5O/c16-11-10(14(17)22)12(8-4-2-1-3-5-8)21-13(11)9-6-7-19-15(18)20-9/h1-7,21H,(H2,17,22)(H2,18,19,20)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329460
PNG
(2-(4-Nitro-phenyl)-5-pyridin-4-yl-1H-pyrrole-3-car...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccc(cc1)[N+]([O-])=O)-c1ccncc1
Show InChI InChI=1S/C16H12N4O3/c17-16(21)13-9-14(10-5-7-18-8-6-10)19-15(13)11-1-3-12(4-2-11)20(22)23/h1-9,19H,(H2,17,21)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187233
PNG
(US9670191, A24)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1[nH]c(cc1C(N)=O)-c1ccncc1
Show InChI InChI=1S/C21H23N5O/c1-25-10-12-26(13-11-25)17-4-2-16(3-5-17)20-18(21(22)27)14-19(24-20)15-6-8-23-9-7-15/h2-9,14,24H,10-13H2,1H3,(H2,22,27)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187248
PNG
(US9670191, F3)
Show SMILES CCc1ccccc1-c1[nH]c(cc1C(N)=O)-c1ccnc(N)n1
Show InChI InChI=1S/C17H17N5O/c1-2-10-5-3-4-6-11(10)15-12(16(18)23)9-14(21-15)13-7-8-20-17(19)22-13/h3-9,21H,2H2,1H3,(H2,18,23)(H2,19,20,22)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187519
PNG
(US9670191, F15)
Show SMILES Cc1cccc(-c2[nH]c(cc2C(N)=O)-c2ccnc(N)n2)c1C
Show InChI InChI=1S/C17H17N5O/c1-9-4-3-5-11(10(9)2)15-12(16(18)23)8-14(21-15)13-6-7-20-17(19)22-13/h3-8,21H,1-2H3,(H2,18,23)(H2,19,20,22)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187552
PNG
(US9670191, F29)
Show SMILES Cc1ccc(F)c(c1)-c1[nH]c(cc1C(N)=O)-c1ccnc(N)n1
Show InChI InChI=1S/C16H14FN5O/c1-8-2-3-11(17)9(6-8)14-10(15(18)23)7-13(21-14)12-4-5-20-16(19)22-12/h2-7,21H,1H3,(H2,18,23)(H2,19,20,22)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187562
PNG
(US9670191, F36)
Show SMILES NC(=O)c1cc([nH]c1-c1ccc(Cl)cc1F)-c1ccnc(N)n1
Show InChI InChI=1S/C15H11ClFN5O/c16-7-1-2-8(10(17)5-7)13-9(14(18)23)6-12(21-13)11-3-4-20-15(19)22-11/h1-6,21H,(H2,18,23)(H2,19,20,22)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187605
PNG
(US9670191, G7)
Show SMILES CC(C)(C)OC(=O)N1CCc2c(C1)cccc2-c1[nH]c(cc1C(N)=O)-c1ccnc(N)n1
Show InChI InChI=1S/C23H26N6O3/c1-23(2,3)32-22(31)29-10-8-14-13(12-29)5-4-6-15(14)19-16(20(24)30)11-18(27-19)17-7-9-26-21(25)28-17/h4-7,9,11,27H,8,10,12H2,1-3H3,(H2,24,30)(H2,25,26,28)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187872
PNG
(US9670191, N4)
Show SMILES NC(=O)c1c(Br)c([nH]c1-c1ccccc1)-c1nc(N)ncc1Br
Show InChI InChI=1S/C15H11Br2N5O/c16-8-6-20-15(19)22-12(8)13-10(17)9(14(18)23)11(21-13)7-4-2-1-3-5-7/h1-6,21H,(H2,18,23)(H2,19,20,22)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329447
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-phenyl-thiophene-3-ca...)
Show SMILES NC(=O)c1cc(sc1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C15H12N4OS/c16-14(20)10-8-12(11-6-7-18-15(17)19-11)21-13(10)9-4-2-1-3-5-9/h1-8H,(H2,16,20)(H2,17,18,19)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187227
PNG
(US9670191, A18)
Show SMILES CC(=O)Nc1cccc(c1)-c1[nH]c(cc1C(N)=O)-c1ccncc1
Show InChI InChI=1S/C18H16N4O2/c1-11(23)21-14-4-2-3-13(9-14)17-15(18(19)24)10-16(22-17)12-5-7-20-8-6-12/h2-10,22H,1H3,(H2,19,24)(H,21,23)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187236
PNG
(US9670191, A27)
Show SMILES CC(C)(C)OC(=O)N1CCc2ccc(cc2C1)-c1[nH]c(cc1C(N)=O)-c1ccncc1
Show InChI InChI=1S/C24H26N4O3/c1-24(2,3)31-23(30)28-11-8-15-4-5-17(12-18(15)14-28)21-19(22(25)29)13-20(27-21)16-6-9-26-10-7-16/h4-7,9-10,12-13,27H,8,11,14H2,1-3H3,(H2,25,29)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187243
PNG
(US9670191, D1)
Show SMILES CCn1c(cc(C(N)=O)c1-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C18H17N3O/c1-2-21-16(13-8-10-20-11-9-13)12-15(18(19)22)17(21)14-6-4-3-5-7-14/h3-12H,2H2,1H3,(H2,19,22)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187523
PNG
(US9670191, F18)
Show SMILES NC(=O)c1cc([nH]c1-c1cc(F)ccc1F)-c1ccnc(N)n1
Show InChI InChI=1S/C15H11F2N5O/c16-7-1-2-10(17)8(5-7)13-9(14(18)23)6-12(21-13)11-3-4-20-15(19)22-11/h1-6,21H,(H2,18,23)(H2,19,20,22)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187526
PNG
(US9670191, F20)
Show SMILES NC(=O)c1cc([nH]c1-c1cccc(Cl)c1)-c1ccnc(N)n1
Show InChI InChI=1S/C15H12ClN5O/c16-9-3-1-2-8(6-9)13-10(14(17)22)7-12(20-13)11-4-5-19-15(18)21-11/h1-7,20H,(H2,17,22)(H2,18,19,21)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187568
PNG
(US9670191, G4)
Show SMILES NC(=O)c1cc([nH]c1-c1ccc(Cl)s1)-c1ccnc(N)n1
Show InChI InChI=1S/C13H10ClN5OS/c14-10-2-1-9(21-10)11-6(12(15)20)5-8(18-11)7-3-4-17-13(16)19-7/h1-5,18H,(H2,15,20)(H2,16,17,19)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187606
PNG
(US9670191, G8)
Show SMILES NC(=O)c1cc([nH]c1-c1cccc2CNCCc12)-c1ccnc(N)n1
Show InChI InChI=1S/C18H18N6O/c19-17(25)13-8-15(14-5-7-22-18(20)24-14)23-16(13)12-3-1-2-10-9-21-6-4-11(10)12/h1-3,5,7-8,21,23H,4,6,9H2,(H2,19,25)(H2,20,22,24)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187616
PNG
(US9670191, G11)
Show SMILES NC(=O)c1cc([nH]c1-c1cccnc1)-c1ccnc(N)n1
Show InChI InChI=1S/C14H12N6O/c15-13(21)9-6-11(10-3-5-18-14(16)20-10)19-12(9)8-2-1-4-17-7-8/h1-7,19H,(H2,15,21)(H2,16,18,20)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187873
PNG
(US9670191, N5)
Show SMILES NC(=O)c1c(I)c([nH]c1-c1ccccc1)-c1nc(N)ncc1I
Show InChI InChI=1S/C15H11I2N5O/c16-8-6-20-15(19)22-12(8)13-10(17)9(14(18)23)11(21-13)7-4-2-1-3-5-7/h1-6,21H,(H2,18,23)(H2,19,20,22)
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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329458
PNG
(5-Pyridin-4-yl-1H-pyrrole-3-carboxylic Acid Amide ...)
Show SMILES NC(=O)c1c[nH]c(c1)-c1ccncc1
Show InChI InChI=1S/C10H9N3O/c11-10(14)8-5-9(13-6-8)7-1-3-12-4-2-7/h1-6,13H,(H2,11,14)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329427
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-c...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C15H13N5O/c16-14(21)10-8-12(11-6-7-18-15(17)20-11)19-13(10)9-4-2-1-3-5-9/h1-8,19H,(H2,16,21)(H2,17,18,20)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187238
PNG
(US9670191, A29)
Show SMILES CN1CCc2ccc(cc2C1)-c1[nH]c(cc1C(N)=O)-c1ccncc1
Show InChI InChI=1S/C20H20N4O/c1-24-9-6-13-2-3-15(10-16(13)12-24)19-17(20(21)25)11-18(23-19)14-4-7-22-8-5-14/h2-5,7-8,10-11,23H,6,9,12H2,1H3,(H2,21,25)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187479
PNG
(US9670191, F8)
Show SMILES NC(=O)c1cc([nH]c1-c1ccc(cc1)-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C21H17N5O/c22-20(27)16-12-18(17-10-11-24-21(23)26-17)25-19(16)15-8-6-14(7-9-15)13-4-2-1-3-5-13/h1-12,25H,(H2,22,27)(H2,23,24,26)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187513
PNG
(US9670191, F10)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C21H17N5O/c22-20(27)16-12-18(17-10-11-24-21(23)26-17)25-19(16)15-9-5-4-8-14(15)13-6-2-1-3-7-13/h1-12,25H,(H2,22,27)(H2,23,24,26)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187518
PNG
(US9670191, F14)
Show SMILES Cc1ccc(F)cc1-c1[nH]c(cc1C(N)=O)-c1ccnc(N)n1
Show InChI InChI=1S/C16H14FN5O/c1-8-2-3-9(17)6-10(8)14-11(15(18)23)7-13(21-14)12-4-5-20-16(19)22-12/h2-7,21H,1H3,(H2,18,23)(H2,19,20,22)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187530
PNG
(US9670191, F23)
Show SMILES NC(=O)c1cc([nH]c1-c1ccc(F)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C15H11ClFN5O/c16-10-5-7(17)1-2-8(10)13-9(14(18)23)6-12(21-13)11-3-4-20-15(19)22-11/h1-6,21H,(H2,18,23)(H2,19,20,22)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50069365
PNG
(CHEMBL3330104 | US9670191, F25)
Show SMILES Cc1ccc(Cl)cc1-c1[nH]c(cc1C(N)=O)-c1ccnc(N)n1
Show InChI InChI=1S/C16H14ClN5O/c1-8-2-3-9(17)6-10(8)14-11(15(18)23)7-13(21-14)12-4-5-20-16(19)22-12/h2-7,21H,1H3,(H2,18,23)(H2,19,20,22)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187549
PNG
(US9670191, F28)
Show SMILES Cc1ccc(-c2[nH]c(cc2C(N)=O)-c2ccnc(N)n2)c(F)c1
Show InChI InChI=1S/C16H14FN5O/c1-8-2-3-9(11(17)6-8)14-10(15(18)23)7-13(21-14)12-4-5-20-16(19)22-12/h2-7,21H,1H3,(H2,18,23)(H2,19,20,22)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187564
PNG
(US9670191, F37)
Show SMILES NC(=O)c1cc([nH]c1-c1c(F)cccc1F)-c1ccnc(N)n1
Show InChI InChI=1S/C15H11F2N5O/c16-8-2-1-3-9(17)12(8)13-7(14(18)23)6-11(21-13)10-4-5-20-15(19)22-10/h1-6,21H,(H2,18,23)(H2,19,20,22)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329445
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-benzofuran-2-yl-1H-py...)
Show SMILES NC(=O)c1cc([nH]c1-c1cc2ccccc2o1)-c1ccnc(N)n1
Show InChI InChI=1S/C17H13N5O2/c18-16(23)10-8-12(11-5-6-20-17(19)22-11)21-15(10)14-7-9-3-1-2-4-13(9)24-14/h1-8,21H,(H2,18,23)(H2,19,20,22)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187611
PNG
(US9670191, G10)
Show SMILES NC(=O)c1cc([nH]c1-c1cccc2oc3ccccc3c12)-c1ccnc(N)n1
Show InChI InChI=1S/C21H15N5O2/c22-20(27)13-10-15(14-8-9-24-21(23)26-14)25-19(13)12-5-3-7-17-18(12)11-4-1-2-6-16(11)28-17/h1-10,25H,(H2,22,27)(H2,23,24,26)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329429
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-(1-methyl-1H-indol-3-...)
Show SMILES Cn1cc(-c2[nH]c(cc2C(N)=O)-c2ccnc(N)n2)c2ccccc12
Show InChI InChI=1S/C18H16N6O/c1-24-9-12(10-4-2-3-5-15(10)24)16-11(17(19)25)8-14(22-16)13-6-7-21-18(20)23-13/h2-9,22H,1H3,(H2,19,25)(H2,20,21,23)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329420
PNG
(5-(2-amino-5-chloropyrimidin-4-yl)-2-p-tolyl-1H-py...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1)-c1nc(N)ncc1Cl
Show InChI InChI=1S/C15H12ClN5O/c16-10-7-19-15(18)21-13(10)11-6-9(14(17)22)12(20-11)8-4-2-1-3-5-8/h1-7,20H,(H2,17,22)(H2,18,19,21)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329469
PNG
(2-Bromo-5-pyridin-4-yl-1H-pyrrole-3-carboxylic Aci...)
Show SMILES NC(=O)c1cc([nH]c1Br)-c1ccncc1
Show InChI InChI=1S/C10H8BrN3O/c11-9-7(10(12)15)5-8(14-9)6-1-3-13-4-2-6/h1-5,14H,(H2,12,15)
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NERVIANO MEDICAL SCIENCES S.R.L.

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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329461
PNG
(2-(3-Cyano-phenyl)-5-pyridin-4-yl-1H-pyrrole-3-car...)
Show SMILES NC(=O)c1cc([nH]c1-c1cccc(c1)C#N)-c1ccncc1
Show InChI InChI=1S/C17H12N4O/c18-10-11-2-1-3-13(8-11)16-14(17(19)22)9-15(21-16)12-4-6-20-7-5-12/h1-9,21H,(H2,19,22)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187234
PNG
(US9670191, A25)
Show SMILES NC(=O)c1cc([nH]c1-c1cccc(c1)N1CCOCC1)-c1ccncc1
Show InChI InChI=1S/C20H20N4O2/c21-20(25)17-13-18(14-4-6-22-7-5-14)23-19(17)15-2-1-3-16(12-15)24-8-10-26-11-9-24/h1-7,12-13,23H,8-11H2,(H2,21,25)
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NERVIANO MEDICAL SCIENCES S.R.L.

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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329452
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-naphthalen-1-yl-1H-py...)
Show SMILES NC(=O)c1cc([nH]c1-c1cccc2ccccc12)-c1ccnc(N)n1
Show InChI InChI=1S/C19H15N5O/c20-18(25)14-10-16(15-8-9-22-19(21)24-15)23-17(14)13-7-3-5-11-4-1-2-6-12(11)13/h1-10,23H,(H2,20,25)(H2,21,22,24)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187505
PNG
(US9670191, F9)
Show SMILES NC(=O)c1cc([nH]c1-c1cccc(c1)-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C21H17N5O/c22-20(27)16-12-18(17-9-10-24-21(23)26-17)25-19(16)15-8-4-7-14(11-15)13-5-2-1-3-6-13/h1-12,25H,(H2,22,27)(H2,23,24,26)
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NERVIANO MEDICAL SCIENCES S.R.L.

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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187514
PNG
(US9670191, F11)
Show SMILES COc1ccccc1-c1[nH]c(cc1C(N)=O)-c1ccnc(N)n1
Show InChI InChI=1S/C16H15N5O2/c1-23-13-5-3-2-4-9(13)14-10(15(17)22)8-12(20-14)11-6-7-19-16(18)21-11/h2-8,20H,1H3,(H2,17,22)(H2,18,19,21)
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NERVIANO MEDICAL SCIENCES S.R.L.

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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187516
PNG
(US9670191, F12)
Show SMILES NC(=O)c1cc([nH]c1-c1ccc2OCOc2c1)-c1ccnc(N)n1
Show InChI InChI=1S/C16H13N5O3/c17-15(22)9-6-11(10-3-4-19-16(18)21-10)20-14(9)8-1-2-12-13(5-8)24-7-23-12/h1-6,20H,7H2,(H2,17,22)(H2,18,19,21)
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NERVIANO MEDICAL SCIENCES S.R.L.

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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187522
PNG
(US9670191, F17)
Show SMILES NC(=O)c1cc([nH]c1-c1ccc(F)cc1F)-c1ccnc(N)n1
Show InChI InChI=1S/C15H11F2N5O/c16-7-1-2-8(10(17)5-7)13-9(14(18)23)6-12(21-13)11-3-4-20-15(19)22-11/h1-6,21H,(H2,18,23)(H2,19,20,22)
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NERVIANO MEDICAL SCIENCES S.R.L.

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Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM187553
PNG
(US9670191, F30)
Show SMILES Cc1cccc(-c2[nH]c(cc2C(N)=O)-c2ccnc(N)n2)c1F
Show InChI InChI=1S/C16H14FN5O/c1-8-3-2-4-9(13(8)17)14-10(15(18)23)7-12(21-14)11-5-6-20-16(19)22-11/h2-7,21H,1H3,(H2,18,23)(H2,19,20,22)
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n/an/a<1.00E+3n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


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More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM50329421
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-benzo[b]thiophen-5-yl...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccc2sccc2c1)-c1ccnc(N)n1
Show InChI InChI=1S/C17H13N5OS/c18-16(23)11-8-13(12-3-5-20-17(19)22-12)21-15(11)10-1-2-14-9(7-10)4-6-24-14/h1-8,21H,(H2,18,23)(H2,19,20,22)
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US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
Cdc7 Kinase


(Homo sapiens (human))
BDBM188074
PNG
(US9670191, R3)
Show SMILES NC(=O)c1cc([nH]c1Br)-c1ccncc1F
Show InChI InChI=1S/C10H7BrFN3O/c11-9-6(10(13)16)3-8(15-9)5-1-2-14-4-7(5)12/h1-4,15H,(H2,13,16)
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US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay consists of the transfer of radioactivity labeled phosphate moiety by the kinase to an acceptor substrate. The resulting 33P-labeled produc...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%