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Patent code US9670193

Compile Data Set for Download or QSAR
Found 138 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187784
PNG
(US9670193, 36 3-chloro-N-(1-(pyridin-4-yl)ethyl)-5...)
Show SMILES CC(Nc1ncc(cc1Cl)-c1noc(n1)C(F)(F)F)c1ccncc1
Show InChI InChI=1S/C15H11ClF3N5O/c1-8(9-2-4-20-5-3-9)22-13-11(16)6-10(7-21-13)12-23-14(25-24-12)15(17,18)19/h2-8H,1H3,(H,21,22)
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Novartis AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187643
PNG
(US9670193, 35 3-chloro-N-(pyridin-4-ylmethyl)-5-(5...)
Show SMILES FC(F)(F)c1nc(no1)-c1cnc(NCc2ccncc2)c(Cl)c1
Show InChI InChI=1S/C14H9ClF3N5O/c15-10-5-9(11-22-13(24-23-11)14(16,17)18)7-21-12(10)20-6-8-1-3-19-4-2-8/h1-5,7H,6H2,(H,20,21)
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Novartis AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187543
PNG
(US9670193, 21 (R)?N-(1-(benzyl(methyl)amino)propan...)
Show SMILES C[C@H](CN(C)Cc1ccccc1)NC(=O)c1ccc(nc1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C20H20F3N5O2/c1-13(11-28(2)12-14-6-4-3-5-7-14)25-18(29)15-8-9-16(24-10-15)17-26-19(30-27-17)20(21,22)23/h3-10,13H,11-12H2,1-2H3,(H,25,29)/t13-/m1/s1
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Novartis AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187802
PNG
(US9670193, 37 3-chloro-N-(pyridin-3-ylmethyl)-5-(5...)
Show SMILES FC(F)(F)c1nc(no1)-c1cnc(NCc2cccnc2)c(Cl)c1
Show InChI InChI=1S/C14H9ClF3N5O/c15-10-4-9(11-22-13(24-23-11)14(16,17)18)7-21-12(10)20-6-8-2-1-3-19-5-8/h1-5,7H,6H2,(H,20,21)
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Novartis AG

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Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187232
PNG
(US9670193, 15 N-(1-(pyridin-4-yl)propyl)-5-(5-(tri...)
Show SMILES CCC(Nc1ncc(cn1)-c1noc(n1)C(F)(F)F)c1ccncc1
Show InChI InChI=1S/C15H13F3N6O/c1-2-11(9-3-5-19-6-4-9)22-14-20-7-10(8-21-14)12-23-13(25-24-12)15(16,17)18/h3-8,11H,2H2,1H3,(H,20,21,22)
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Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187803
PNG
(US9670193, 38 3-Chloro-N-((6-methylpyridin-3-yl)me...)
Show SMILES Cc1ccc(CNc2ncc(cc2Cl)-c2noc(n2)C(F)(F)F)cn1
Show InChI InChI=1S/C15H11ClF3N5O/c1-8-2-3-9(5-20-8)6-21-13-11(16)4-10(7-22-13)12-23-14(25-24-12)15(17,18)19/h2-5,7H,6H2,1H3,(H,21,22)
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Novartis AG

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Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187219
PNG
(US9670193, 9 N-(1-(pyridin-4-yl)ethyl)-5-(5-(trifl...)
Show SMILES CC(Nc1ncc(cn1)-c1noc(n1)C(F)(F)F)c1ccncc1
Show InChI InChI=1S/C14H11F3N6O/c1-8(9-2-4-18-5-3-9)21-13-19-6-10(7-20-13)11-22-12(24-23-11)14(15,16)17/h2-8H,1H3,(H,19,20,21)
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Novartis AG

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Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187223
PNG
(US9670193, 13 (R)?N-(1-phenylpropyl)-5-(5-(trifluo...)
Show SMILES CC[C@@H](Nc1ncc(cn1)-c1noc(n1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C16H14F3N5O/c1-2-12(10-6-4-3-5-7-10)22-15-20-8-11(9-21-15)13-23-14(25-24-13)16(17,18)19/h3-9,12H,2H2,1H3,(H,20,21,22)/t12-/m1/s1
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Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187218
PNG
(US9670193, 8 N-((6-methylpyridin-3-yl)methyl)-5-(5...)
Show SMILES Cc1ccc(CNc2ncc(cn2)-c2noc(n2)C(F)(F)F)cn1
Show InChI InChI=1S/C14H11F3N6O/c1-8-2-3-9(4-18-8)5-19-13-20-6-10(7-21-13)11-22-12(24-23-11)14(15,16)17/h2-4,6-7H,5H2,1H3,(H,19,20,21)
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Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187628
PNG
(US9670193, 29 N-(1-phenylethyl)-5-(5-(trifluoromet...)
Show SMILES CC(Nc1ccc(cn1)-c1noc(n1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C16H13F3N4O/c1-10(11-5-3-2-4-6-11)21-13-8-7-12(9-20-13)14-22-15(24-23-14)16(17,18)19/h2-10H,1H3,(H,20,21)
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Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187565
PNG
(US9670193, 23 (R)?N-(1-(diethylamino)propan-2-yl)-...)
Show SMILES CCN(CC)C[C@@H](C)NC(=O)c1ccc(nc1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C16H20F3N5O2/c1-4-24(5-2)9-10(3)21-14(25)11-6-7-12(20-8-11)13-22-15(26-23-13)16(17,18)19/h6-8,10H,4-5,9H2,1-3H3,(H,21,25)/t10-/m1/s1
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Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM188028
PNG
(US9670193, 44 (R)?N-(Pyridin-4-yl)ethyl)-5-(5-trif...)
Show SMILES C[C@@H](Nc1ccc(cn1)-c1noc(n1)C(F)(F)F)c1ccncc1
Show InChI InChI=1S/C15H12F3N5O/c1-9(10-4-6-19-7-5-10)21-12-3-2-11(8-20-12)13-22-14(24-23-13)15(16,17)18/h2-9H,1H3,(H,20,21)/t9-/m1/s1
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Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187244
PNG
(US9670193, 17 N-methyl-N-((2-methylpyridin-4-yl)me...)
Show SMILES CN(Cc1ccnc(C)c1)c1ncc(cn1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C15H13F3N6O/c1-9-5-10(3-4-19-9)8-24(2)14-20-6-11(7-21-14)12-22-13(25-23-12)15(16,17)18/h3-7H,8H2,1-2H3
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Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187213
PNG
(US9670193, 4 N-benzyl-5-(5-(trifluoromethyl)-1,2,4...)
Show SMILES FC(F)(F)c1nc(no1)-c1cnc(NCc2ccccc2)nc1
Show InChI InChI=1S/C14H10F3N5O/c15-14(16,17)12-21-11(22-23-12)10-7-19-13(20-8-10)18-6-9-4-2-1-3-5-9/h1-5,7-8H,6H2,(H,18,19,20)
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Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187804
PNG
(US9670193, 39 3-chloro-N-(pyridin-2-ylmethyl)-5-(5...)
Show SMILES FC(F)(F)c1nc(no1)-c1cnc(NCc2ccccn2)c(Cl)c1
Show InChI InChI=1S/C14H9ClF3N5O/c15-10-5-8(11-22-13(24-23-11)14(16,17)18)6-20-12(10)21-7-9-3-1-2-4-19-9/h1-6H,7H2,(H,20,21)
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Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187187
PNG
(US9670193, 3 N-methyl-N-(pyridin-4-ylmethyl)-5-(5-...)
Show SMILES CN(Cc1ccncc1)c1ncc(cn1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C14H11F3N6O/c1-23(8-9-2-4-18-5-3-9)13-19-6-10(7-20-13)11-21-12(24-22-11)14(15,16)17/h2-7H,8H2,1H3
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Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187214
PNG
(US9670193, 5 N-((2-chloropyridin-4-yl)methyl)-N-me...)
Show SMILES CN(Cc1ccnc(Cl)c1)c1ncc(cn1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C14H10ClF3N6O/c1-24(7-8-2-3-19-10(15)4-8)13-20-5-9(6-21-13)11-22-12(25-23-11)14(16,17)18/h2-6H,7H2,1H3
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Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187638
PNG
(US9670193, 31 N-(pyridin-4-ylmethyl)-5-(5-(trifluo...)
Show SMILES FC(F)(F)c1nc(no1)-c1ccc(NCc2ccncc2)nc1
Show InChI InChI=1S/C14H10F3N5O/c15-14(16,17)13-21-12(22-23-13)10-1-2-11(20-8-10)19-7-9-3-5-18-6-4-9/h1-6,8H,7H2,(H,19,20)
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Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187215
PNG
(US9670193, 6 N-(pyridin-4-ylmethyl)-5-(5-(trifluor...)
Show SMILES FC(F)(F)c1nc(no1)-c1cnc(NCc2ccncc2)nc1
Show InChI InChI=1S/C13H9F3N6O/c14-13(15,16)11-21-10(22-23-11)9-6-19-12(20-7-9)18-5-8-1-3-17-4-2-8/h1-4,6-7H,5H2,(H,18,19,20)
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Novartis AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187242
PNG
(US9670193, 16 N-(1-(2-methylpyridin-4-yl)ethyl)-5-...)
Show SMILES CC(Nc1ncc(cn1)-c1noc(n1)C(F)(F)F)c1ccnc(C)c1
Show InChI InChI=1S/C15H13F3N6O/c1-8-5-10(3-4-19-8)9(2)22-14-20-6-11(7-21-14)12-23-13(25-24-12)15(16,17)18/h3-7,9H,1-2H3,(H,20,21,22)
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Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187642
PNG
(US9670193, 34 (R)-3-chloro-N-(1-phenylethyl)-5-(5-...)
Show SMILES C[C@@H](Nc1ncc(cc1Cl)-c1noc(n1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C16H12ClF3N4O/c1-9(10-5-3-2-4-6-10)22-14-12(17)7-11(8-21-14)13-23-15(25-24-13)16(18,19)20/h2-9H,1H3,(H,21,22)/t9-/m1/s1
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Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187222
PNG
(US9670193, 12 (R)?N-(1-phenylethyl)-5-(5-(trifluor...)
Show SMILES C[C@@H](Nc1ncc(cn1)-c1noc(n1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C15H12F3N5O/c1-9(10-5-3-2-4-6-10)21-14-19-7-11(8-20-14)12-22-13(24-23-12)15(16,17)18/h2-9H,1H3,(H,19,20,21)/t9-/m1/s1
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US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM188006
PNG
(US9670193, 41 (R)?N-(1-Phenylethyl)-2-(5-(trifluor...)
Show SMILES C[C@@H](Nc1cnc(nc1)-c1noc(n1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C15H12F3N5O/c1-9(10-5-3-2-4-6-10)21-11-7-19-12(20-8-11)13-22-14(24-23-13)15(16,17)18/h2-9,21H,1H3/t9-/m1/s1
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Novartis AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187639
PNG
(US9670193, 32 N-((6-methylpyridin-3-yl)methyl)-5-(...)
Show SMILES Cc1ccc(CNc2ccc(cn2)-c2noc(n2)C(F)(F)F)cn1
Show InChI InChI=1S/C15H12F3N5O/c1-9-2-3-10(6-19-9)7-20-12-5-4-11(8-21-12)13-22-14(24-23-13)15(16,17)18/h2-6,8H,7H2,1H3,(H,20,21)
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Novartis AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM188029
PNG
(US9670193, 45 (R)?N-(1-(Pyridin-4-yl)ethyl)-6-(5-(...)
Show SMILES C[C@@H](Nc1ccc(nn1)-c1noc(n1)C(F)(F)F)c1ccncc1
Show InChI InChI=1S/C14H11F3N6O/c1-8(9-4-6-18-7-5-9)19-11-3-2-10(21-22-11)12-20-13(24-23-12)14(15,16)17/h2-8H,1H3,(H,19,22)/t8-/m1/s1
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Novartis AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM188075
PNG
(US9670193, 46 (R)?N-(1-(benzyl(methyl)amino)propan...)
Show SMILES C[C@H](CN(C)Cc1ccccc1)NC(=O)c1cnc(nc1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C19H19F3N6O2/c1-12(10-28(2)11-13-6-4-3-5-7-13)25-17(29)14-8-23-15(24-9-14)16-26-18(30-27-16)19(20,21)22/h3-9,12H,10-11H2,1-2H3,(H,25,29)/t12-/m1/s1
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Novartis AG

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Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187617
PNG
(US9670193, 28 N-benzyl-5-(5-(trifluoromethyl)-1,2,...)
Show SMILES FC(F)(F)c1nc(no1)-c1ccc(NCc2ccccc2)nc1
Show InChI InChI=1S/C15H11F3N4O/c16-15(17,18)14-21-13(22-23-14)11-6-7-12(20-9-11)19-8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H,19,20)
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Novartis AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187629
PNG
(US9670193, 30 N-(pyridin-3-ylmethyl)-5-(5-(trifluo...)
Show SMILES FC(F)(F)c1nc(no1)-c1ccc(NCc2cccnc2)nc1
Show InChI InChI=1S/C14H10F3N5O/c15-14(16,17)13-21-12(22-23-13)10-3-4-11(20-8-10)19-7-9-2-1-5-18-6-9/h1-6,8H,7H2,(H,19,20)
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Novartis AG

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Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187640
PNG
(US9670193, 33 N-benzyl-3-chloro-5-(5-(trifluoromet...)
Show SMILES FC(F)(F)c1nc(no1)-c1cnc(NCc2ccccc2)c(Cl)c1
Show InChI InChI=1S/C15H10ClF3N4O/c16-11-6-10(12-22-14(24-23-12)15(17,18)19)8-21-13(11)20-7-9-4-2-1-3-5-9/h1-6,8H,7H2,(H,20,21)
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Novartis AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187224
PNG
(US9670193, 14 N-methyl-N-(2-(pyridin-4-yl)ethyl)-5...)
Show SMILES CN(CCc1ccncc1)c1ncc(cn1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C15H13F3N6O/c1-24(7-4-10-2-5-19-6-3-10)14-20-8-11(9-21-14)12-22-13(25-23-12)15(16,17)18/h2-3,5-6,8-9H,4,7H2,1H3
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Novartis AG

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Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187217
PNG
(US9670193, 7 N-(1-phenylethyl)-5-(5-(trifluorometh...)
Show SMILES CC(Nc1ncc(cn1)-c1noc(n1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C15H12F3N5O/c1-9(10-5-3-2-4-6-10)21-14-19-7-11(8-20-14)12-22-13(24-23-12)15(16,17)18/h2-9H,1H3,(H,19,20,21)
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Novartis AG

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Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187220
PNG
(US9670193, 10 N-(pyridin-3-ylmethyl)-5-(5-(trifluo...)
Show SMILES FC(F)(F)c1nc(no1)-c1cnc(NCc2cccnc2)nc1
Show InChI InChI=1S/C13H9F3N6O/c14-13(15,16)11-21-10(22-23-11)9-6-19-12(20-7-9)18-5-8-2-1-3-17-4-8/h1-4,6-7H,5H2,(H,18,19,20)
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Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187223
PNG
(US9670193, 13 (R)?N-(1-phenylpropyl)-5-(5-(trifluo...)
Show SMILES CC[C@@H](Nc1ncc(cn1)-c1noc(n1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C16H14F3N5O/c1-2-12(10-6-4-3-5-7-10)22-15-20-8-11(9-21-15)13-23-14(25-24-13)16(17,18)19/h3-9,12H,2H2,1H3,(H,20,21,22)/t12-/m1/s1
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187547
PNG
(US9670193, 22 (R)?N-(1-(diethylamino)-3-methylbuta...)
Show SMILES CCN(CC)C[C@H](NC(=O)c1ccc(nc1)-c1noc(n1)C(F)(F)F)C(C)C
Show InChI InChI=1S/C18H24F3N5O2/c1-5-26(6-2)10-14(11(3)4)23-16(27)12-7-8-13(22-9-12)15-24-17(28-25-15)18(19,20)21/h7-9,11,14H,5-6,10H2,1-4H3,(H,23,27)/t14-/m0/s1
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Novartis AG

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Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM188027
PNG
(US9670193, 43 N-(Pyridin-4-ylmethyl)-2-(5-(trifluo...)
Show SMILES FC(F)(F)c1nc(no1)-c1ncc(NCc2ccncc2)cn1
Show InChI InChI=1S/C13H9F3N6O/c14-13(15,16)12-21-11(22-23-12)10-19-6-9(7-20-10)18-5-8-1-3-17-4-2-8/h1-4,6-7,18H,5H2
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Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187993
PNG
(US9670193, 40 N-benzyl-6-(5-(trifluoromethyl)-1,2,...)
Show SMILES FC(F)(F)c1nc(no1)-c1ccc(NCc2ccccc2)nn1
Show InChI InChI=1S/C14H10F3N5O/c15-14(16,17)13-19-12(22-23-13)10-6-7-11(21-20-10)18-8-9-4-2-1-3-5-9/h1-7H,8H2,(H,18,21)
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Novartis AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187232
PNG
(US9670193, 15 N-(1-(pyridin-4-yl)propyl)-5-(5-(tri...)
Show SMILES CCC(Nc1ncc(cn1)-c1noc(n1)C(F)(F)F)c1ccncc1
Show InChI InChI=1S/C15H13F3N6O/c1-2-11(9-3-5-19-6-4-9)22-14-20-7-10(8-21-14)12-23-13(25-24-12)15(16,17)18/h3-8,11H,2H2,1H3,(H,20,21,22)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187221
PNG
(US9670193, 11 N-((6-methylpyridin-2-yl)methyl)-5-(...)
Show SMILES Cc1cccc(CNc2ncc(cn2)-c2noc(n2)C(F)(F)F)n1
Show InChI InChI=1S/C14H11F3N6O/c1-8-3-2-4-10(21-8)7-20-13-18-5-9(6-19-13)11-22-12(24-23-11)14(15,16)17/h2-6H,7H2,1H3,(H,18,19,20)
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US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187246
PNG
(US9670193, 18 (R)?N-(1-(dimethylamino)propan-2-yl)...)
Show SMILES C[C@H](CN(C)C)NC(=O)c1ccc(nc1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C14H16F3N5O2/c1-8(7-22(2)3)19-12(23)9-4-5-10(18-6-9)11-20-13(24-21-11)14(15,16)17/h4-6,8H,7H2,1-3H3,(H,19,23)/t8-/m1/s1
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Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187218
PNG
(US9670193, 8 N-((6-methylpyridin-3-yl)methyl)-5-(5...)
Show SMILES Cc1ccc(CNc2ncc(cn2)-c2noc(n2)C(F)(F)F)cn1
Show InChI InChI=1S/C14H11F3N6O/c1-8-2-3-9(4-18-8)5-19-13-20-6-10(7-21-13)11-22-12(24-23-11)14(15,16)17/h2-4,6-7H,5H2,1H3,(H,19,20,21)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187213
PNG
(US9670193, 4 N-benzyl-5-(5-(trifluoromethyl)-1,2,4...)
Show SMILES FC(F)(F)c1nc(no1)-c1cnc(NCc2ccccc2)nc1
Show InChI InChI=1S/C14H10F3N5O/c15-14(16,17)12-21-11(22-23-12)10-7-19-13(20-8-10)18-6-9-4-2-1-3-5-9/h1-5,7-8H,6H2,(H,18,19,20)
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Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187222
PNG
(US9670193, 12 (R)?N-(1-phenylethyl)-5-(5-(trifluor...)
Show SMILES C[C@@H](Nc1ncc(cn1)-c1noc(n1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C15H12F3N5O/c1-9(10-5-3-2-4-6-10)21-14-19-7-11(8-20-14)12-22-13(24-23-12)15(16,17)18/h2-9H,1H3,(H,19,20,21)/t9-/m1/s1
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Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187307
PNG
(US9670193, 19 N-(1-(dimethylamino)propan-2-yl)-6-(...)
Show SMILES CC(CN(C)C)NC(=O)c1ccc(nc1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C14H16F3N5O2/c1-8(7-22(2)3)19-12(23)9-4-5-10(18-6-9)11-20-13(24-21-11)14(15,16)17/h4-6,8H,7H2,1-3H3,(H,19,23)
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Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187242
PNG
(US9670193, 16 N-(1-(2-methylpyridin-4-yl)ethyl)-5-...)
Show SMILES CC(Nc1ncc(cn1)-c1noc(n1)C(F)(F)F)c1ccnc(C)c1
Show InChI InChI=1S/C15H13F3N6O/c1-8-5-10(3-4-19-8)9(2)22-14-20-6-11(7-21-14)12-23-13(25-24-12)15(16,17)18/h3-7,9H,1-2H3,(H,20,21,22)
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Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187217
PNG
(US9670193, 7 N-(1-phenylethyl)-5-(5-(trifluorometh...)
Show SMILES CC(Nc1ncc(cn1)-c1noc(n1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C15H12F3N5O/c1-9(10-5-3-2-4-6-10)21-14-19-7-11(8-20-14)12-22-13(24-23-12)15(16,17)18/h2-9H,1H3,(H,19,20,21)
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Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187604
PNG
(US9670193, 26 (R)?N-(1-(dimethylamino)propan-2-yl)...)
Show SMILES C[C@H](CN(C)C)NC(=O)c1cnc(nc1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C13H15F3N6O2/c1-7(6-22(2)3)19-11(23)8-4-17-9(18-5-8)10-20-12(24-21-10)13(14,15)16/h4-5,7H,6H2,1-3H3,(H,19,23)/t7-/m1/s1
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Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187138
PNG
(US9670193, 1 N-(5-(5-(trifluoromethyl)-1,2,4-oxadi...)
Show SMILES CC(=O)Nc1cnc(cn1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C9H6F3N5O2/c1-4(18)15-6-3-13-5(2-14-6)7-16-8(19-17-7)9(10,11)12/h2-3H,1H3,(H,14,15,18)
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Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187221
PNG
(US9670193, 11 N-((6-methylpyridin-2-yl)methyl)-5-(...)
Show SMILES Cc1cccc(CNc2ncc(cn2)-c2noc(n2)C(F)(F)F)n1
Show InChI InChI=1S/C14H11F3N6O/c1-8-3-2-4-10(21-8)7-20-13-18-5-9(6-19-13)11-22-12(24-23-11)14(15,16)17/h2-6H,7H2,1H3,(H,18,19,20)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187221
PNG
(US9670193, 11 N-((6-methylpyridin-2-yl)methyl)-5-(...)
Show SMILES Cc1cccc(CNc2ncc(cn2)-c2noc(n2)C(F)(F)F)n1
Show InChI InChI=1S/C14H11F3N6O/c1-8-3-2-4-10(21-8)7-20-13-18-5-9(6-19-13)11-22-12(24-23-11)14(15,16)17/h2-6H,7H2,1H3,(H,18,19,20)
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n/an/a 550n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187219
PNG
(US9670193, 9 N-(1-(pyridin-4-yl)ethyl)-5-(5-(trifl...)
Show SMILES CC(Nc1ncc(cn1)-c1noc(n1)C(F)(F)F)c1ccncc1
Show InChI InChI=1S/C14H11F3N6O/c1-8(9-2-4-18-5-3-9)21-13-19-6-10(7-20-13)11-22-12(24-23-11)14(15,16)17/h2-8H,1H3,(H,19,20,21)
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n/an/a 560n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM188029
PNG
(US9670193, 45 (R)?N-(1-(Pyridin-4-yl)ethyl)-6-(5-(...)
Show SMILES C[C@@H](Nc1ccc(nn1)-c1noc(n1)C(F)(F)F)c1ccncc1
Show InChI InChI=1S/C14H11F3N6O/c1-8(9-4-6-18-7-5-9)19-11-3-2-10(21-22-11)12-20-13(24-23-12)14(15,16)17/h2-8H,1H3,(H,19,22)/t8-/m1/s1
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187215
PNG
(US9670193, 6 N-(pyridin-4-ylmethyl)-5-(5-(trifluor...)
Show SMILES FC(F)(F)c1nc(no1)-c1cnc(NCc2ccncc2)nc1
Show InChI InChI=1S/C13H9F3N6O/c14-13(15,16)11-21-10(22-23-11)9-6-19-12(20-7-9)18-5-8-1-3-17-4-2-8/h1-4,6-7H,5H2,(H,18,19,20)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187628
PNG
(US9670193, 29 N-(1-phenylethyl)-5-(5-(trifluoromet...)
Show SMILES CC(Nc1ccc(cn1)-c1noc(n1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C16H13F3N4O/c1-10(11-5-3-2-4-6-11)21-13-8-7-12(9-20-13)14-22-15(24-23-14)16(17,18)19/h2-10H,1H3,(H,20,21)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187639
PNG
(US9670193, 32 N-((6-methylpyridin-3-yl)methyl)-5-(...)
Show SMILES Cc1ccc(CNc2ccc(cn2)-c2noc(n2)C(F)(F)F)cn1
Show InChI InChI=1S/C15H12F3N5O/c1-9-2-3-10(6-19-9)7-20-12-5-4-11(8-21-12)13-22-14(24-23-13)15(16,17)18/h2-6,8H,7H2,1H3,(H,20,21)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187993
PNG
(US9670193, 40 N-benzyl-6-(5-(trifluoromethyl)-1,2,...)
Show SMILES FC(F)(F)c1nc(no1)-c1ccc(NCc2ccccc2)nn1
Show InChI InChI=1S/C14H10F3N5O/c15-14(16,17)13-19-12(22-23-13)10-6-7-11(21-20-10)18-8-9-4-2-1-3-5-9/h1-7H,8H2,(H,18,21)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187784
PNG
(US9670193, 36 3-chloro-N-(1-(pyridin-4-yl)ethyl)-5...)
Show SMILES CC(Nc1ncc(cc1Cl)-c1noc(n1)C(F)(F)F)c1ccncc1
Show InChI InChI=1S/C15H11ClF3N5O/c1-8(9-2-4-20-5-3-9)22-13-11(16)6-10(7-21-13)12-23-14(25-24-12)15(17,18)19/h2-8H,1H3,(H,21,22)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187566
PNG
(US9670193, 24 (R)?N-(1-(dimethylamino)propan-2-yl)...)
Show SMILES C[C@H](CN(C)C)NC(=O)c1ccc(cn1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C14H16F3N5O2/c1-8(7-22(2)3)19-12(23)10-5-4-9(6-18-10)11-20-13(24-21-11)14(15,16)17/h4-6,8H,7H2,1-3H3,(H,19,23)/t8-/m1/s1
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n/an/a 990n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187215
PNG
(US9670193, 6 N-(pyridin-4-ylmethyl)-5-(5-(trifluor...)
Show SMILES FC(F)(F)c1nc(no1)-c1cnc(NCc2ccncc2)nc1
Show InChI InChI=1S/C13H9F3N6O/c14-13(15,16)11-21-10(22-23-11)9-6-19-12(20-7-9)18-5-8-1-3-17-4-2-8/h1-4,6-7H,5H2,(H,18,19,20)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM188028
PNG
(US9670193, 44 (R)?N-(Pyridin-4-yl)ethyl)-5-(5-trif...)
Show SMILES C[C@@H](Nc1ccc(cn1)-c1noc(n1)C(F)(F)F)c1ccncc1
Show InChI InChI=1S/C15H12F3N5O/c1-9(10-4-6-19-7-5-10)21-12-3-2-11(8-20-12)13-22-14(24-23-13)15(16,17)18/h2-9H,1H3,(H,20,21)/t9-/m1/s1
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187643
PNG
(US9670193, 35 3-chloro-N-(pyridin-4-ylmethyl)-5-(5...)
Show SMILES FC(F)(F)c1nc(no1)-c1cnc(NCc2ccncc2)c(Cl)c1
Show InChI InChI=1S/C14H9ClF3N5O/c15-10-5-9(11-22-13(24-23-11)14(16,17)18)7-21-12(10)20-6-8-1-3-19-4-2-8/h1-5,7H,6H2,(H,20,21)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187220
PNG
(US9670193, 10 N-(pyridin-3-ylmethyl)-5-(5-(trifluo...)
Show SMILES FC(F)(F)c1nc(no1)-c1cnc(NCc2cccnc2)nc1
Show InChI InChI=1S/C13H9F3N6O/c14-13(15,16)11-21-10(22-23-11)9-6-19-12(20-7-9)18-5-8-2-1-3-17-4-8/h1-4,6-7H,5H2,(H,18,19,20)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM188027
PNG
(US9670193, 43 N-(Pyridin-4-ylmethyl)-2-(5-(trifluo...)
Show SMILES FC(F)(F)c1nc(no1)-c1ncc(NCc2ccncc2)cn1
Show InChI InChI=1S/C13H9F3N6O/c14-13(15,16)12-21-11(22-23-12)10-19-6-9(7-20-10)18-5-8-1-3-17-4-2-8/h1-4,6-7,18H,5H2
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187784
PNG
(US9670193, 36 3-chloro-N-(1-(pyridin-4-yl)ethyl)-5...)
Show SMILES CC(Nc1ncc(cc1Cl)-c1noc(n1)C(F)(F)F)c1ccncc1
Show InChI InChI=1S/C15H11ClF3N5O/c1-8(9-2-4-20-5-3-9)22-13-11(16)6-10(7-21-13)12-23-14(25-24-12)15(17,18)19/h2-8H,1H3,(H,21,22)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187802
PNG
(US9670193, 37 3-chloro-N-(pyridin-3-ylmethyl)-5-(5...)
Show SMILES FC(F)(F)c1nc(no1)-c1cnc(NCc2cccnc2)c(Cl)c1
Show InChI InChI=1S/C14H9ClF3N5O/c15-10-4-9(11-22-13(24-23-11)14(16,17)18)7-21-12(10)20-6-8-2-1-3-19-5-8/h1-5,7H,6H2,(H,20,21)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM188006
PNG
(US9670193, 41 (R)?N-(1-Phenylethyl)-2-(5-(trifluor...)
Show SMILES C[C@@H](Nc1cnc(nc1)-c1noc(n1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C15H12F3N5O/c1-9(10-5-3-2-4-6-10)21-11-7-19-12(20-8-11)13-22-14(24-23-13)15(16,17)18/h2-9,21H,1H3/t9-/m1/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187177
PNG
(US9670193, 2 4-Cyano-N-(5-(5-(trifluoromethyl)-1,2...)
Show SMILES FC(F)(F)c1nc(no1)-c1cnc(NC(=O)c2ccc(cc2)C#N)cn1
Show InChI InChI=1S/C15H7F3N6O2/c16-15(17,18)14-23-12(24-26-14)10-6-21-11(7-20-10)22-13(25)9-3-1-8(5-19)2-4-9/h1-4,6-7H,(H,21,22,25)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187803
PNG
(US9670193, 38 3-Chloro-N-((6-methylpyridin-3-yl)me...)
Show SMILES Cc1ccc(CNc2ncc(cc2Cl)-c2noc(n2)C(F)(F)F)cn1
Show InChI InChI=1S/C15H11ClF3N5O/c1-8-2-3-9(5-20-8)6-21-13-11(16)4-10(7-22-13)12-23-14(25-24-12)15(17,18)19/h2-5,7H,6H2,1H3,(H,21,22)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187803
PNG
(US9670193, 38 3-Chloro-N-((6-methylpyridin-3-yl)me...)
Show SMILES Cc1ccc(CNc2ncc(cc2Cl)-c2noc(n2)C(F)(F)F)cn1
Show InChI InChI=1S/C15H11ClF3N5O/c1-8-2-3-9(5-20-8)6-21-13-11(16)4-10(7-22-13)12-23-14(25-24-12)15(17,18)19/h2-5,7H,6H2,1H3,(H,21,22)
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n/an/a 1.55E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187638
PNG
(US9670193, 31 N-(pyridin-4-ylmethyl)-5-(5-(trifluo...)
Show SMILES FC(F)(F)c1nc(no1)-c1ccc(NCc2ccncc2)nc1
Show InChI InChI=1S/C14H10F3N5O/c15-14(16,17)13-21-12(22-23-13)10-1-2-11(20-8-10)19-7-9-3-5-18-6-4-9/h1-6,8H,7H2,(H,19,20)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187242
PNG
(US9670193, 16 N-(1-(2-methylpyridin-4-yl)ethyl)-5-...)
Show SMILES CC(Nc1ncc(cn1)-c1noc(n1)C(F)(F)F)c1ccnc(C)c1
Show InChI InChI=1S/C15H13F3N6O/c1-8-5-10(3-4-19-8)9(2)22-14-20-6-11(7-21-14)12-23-13(25-24-12)15(16,17)18/h3-7,9H,1-2H3,(H,20,21,22)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187223
PNG
(US9670193, 13 (R)?N-(1-phenylpropyl)-5-(5-(trifluo...)
Show SMILES CC[C@@H](Nc1ncc(cn1)-c1noc(n1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C16H14F3N5O/c1-2-12(10-6-4-3-5-7-10)22-15-20-8-11(9-21-15)13-23-14(25-24-13)16(17,18)19/h3-9,12H,2H2,1H3,(H,20,21,22)/t12-/m1/s1
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187214
PNG
(US9670193, 5 N-((2-chloropyridin-4-yl)methyl)-N-me...)
Show SMILES CN(Cc1ccnc(Cl)c1)c1ncc(cn1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C14H10ClF3N6O/c1-24(7-8-2-3-19-10(15)4-8)13-20-5-9(6-21-13)11-22-12(25-23-11)14(16,17)18/h2-6H,7H2,1H3
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187307
PNG
(US9670193, 19 N-(1-(dimethylamino)propan-2-yl)-6-(...)
Show SMILES CC(CN(C)C)NC(=O)c1ccc(nc1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C14H16F3N5O2/c1-8(7-22(2)3)19-12(23)9-4-5-10(18-6-9)11-20-13(24-21-11)14(15,16)17/h4-6,8H,7H2,1-3H3,(H,19,23)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187138
PNG
(US9670193, 1 N-(5-(5-(trifluoromethyl)-1,2,4-oxadi...)
Show SMILES CC(=O)Nc1cnc(cn1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C9H6F3N5O2/c1-4(18)15-6-3-13-5(2-14-6)7-16-8(19-17-7)9(10,11)12/h2-3H,1H3,(H,14,15,18)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187629
PNG
(US9670193, 30 N-(pyridin-3-ylmethyl)-5-(5-(trifluo...)
Show SMILES FC(F)(F)c1nc(no1)-c1ccc(NCc2cccnc2)nc1
Show InChI InChI=1S/C14H10F3N5O/c15-14(16,17)13-21-12(22-23-13)10-3-4-11(20-8-10)19-7-9-2-1-5-18-6-9/h1-6,8H,7H2,(H,19,20)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187643
PNG
(US9670193, 35 3-chloro-N-(pyridin-4-ylmethyl)-5-(5...)
Show SMILES FC(F)(F)c1nc(no1)-c1cnc(NCc2ccncc2)c(Cl)c1
Show InChI InChI=1S/C14H9ClF3N5O/c15-10-5-9(11-22-13(24-23-11)14(16,17)18)7-21-12(10)20-6-8-1-3-19-4-2-8/h1-5,7H,6H2,(H,20,21)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM188008
PNG
(US9670193, 42 (S)?N-(1-Phenylethyl)-2-(5-(trifluor...)
Show SMILES C[C@H](Nc1cnc(nc1)-c1noc(n1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C15H12F3N5O/c1-9(10-5-3-2-4-6-10)21-11-7-19-12(20-8-11)13-22-14(24-23-13)15(16,17)18/h2-9,21H,1H3/t9-/m0/s1
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187804
PNG
(US9670193, 39 3-chloro-N-(pyridin-2-ylmethyl)-5-(5...)
Show SMILES FC(F)(F)c1nc(no1)-c1cnc(NCc2ccccn2)c(Cl)c1
Show InChI InChI=1S/C14H9ClF3N5O/c15-10-5-8(11-22-13(24-23-11)14(16,17)18)6-20-12(10)21-7-9-3-1-2-4-19-9/h1-6H,7H2,(H,20,21)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187802
PNG
(US9670193, 37 3-chloro-N-(pyridin-3-ylmethyl)-5-(5...)
Show SMILES FC(F)(F)c1nc(no1)-c1cnc(NCc2cccnc2)c(Cl)c1
Show InChI InChI=1S/C14H9ClF3N5O/c15-10-4-9(11-22-13(24-23-11)14(16,17)18)7-21-12(10)20-6-8-2-1-3-19-5-8/h1-5,7H,6H2,(H,20,21)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187214
PNG
(US9670193, 5 N-((2-chloropyridin-4-yl)methyl)-N-me...)
Show SMILES CN(Cc1ccnc(Cl)c1)c1ncc(cn1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C14H10ClF3N6O/c1-24(7-8-2-3-19-10(15)4-8)13-20-5-9(6-21-13)11-22-12(25-23-11)14(16,17)18/h2-6H,7H2,1H3
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n/an/a 2.10E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187244
PNG
(US9670193, 17 N-methyl-N-((2-methylpyridin-4-yl)me...)
Show SMILES CN(Cc1ccnc(C)c1)c1ncc(cn1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C15H13F3N6O/c1-9-5-10(3-4-19-9)8-24(2)14-20-6-11(7-21-14)12-22-13(25-23-12)15(16,17)18/h3-7H,8H2,1-2H3
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187639
PNG
(US9670193, 32 N-((6-methylpyridin-3-yl)methyl)-5-(...)
Show SMILES Cc1ccc(CNc2ccc(cn2)-c2noc(n2)C(F)(F)F)cn1
Show InChI InChI=1S/C15H12F3N5O/c1-9-2-3-10(6-19-9)7-20-12-5-4-11(8-21-12)13-22-14(24-23-13)15(16,17)18/h2-6,8H,7H2,1H3,(H,20,21)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187804
PNG
(US9670193, 39 3-chloro-N-(pyridin-2-ylmethyl)-5-(5...)
Show SMILES FC(F)(F)c1nc(no1)-c1cnc(NCc2ccccn2)c(Cl)c1
Show InChI InChI=1S/C14H9ClF3N5O/c15-10-5-8(11-22-13(24-23-11)14(16,17)18)6-20-12(10)21-7-9-3-1-2-4-19-9/h1-6H,7H2,(H,20,21)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187232
PNG
(US9670193, 15 N-(1-(pyridin-4-yl)propyl)-5-(5-(tri...)
Show SMILES CCC(Nc1ncc(cn1)-c1noc(n1)C(F)(F)F)c1ccncc1
Show InChI InChI=1S/C15H13F3N6O/c1-2-11(9-3-5-19-6-4-9)22-14-20-7-10(8-21-14)12-23-13(25-24-12)15(16,17)18/h3-8,11H,2H2,1H3,(H,20,21,22)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187177
PNG
(US9670193, 2 4-Cyano-N-(5-(5-(trifluoromethyl)-1,2...)
Show SMILES FC(F)(F)c1nc(no1)-c1cnc(NC(=O)c2ccc(cc2)C#N)cn1
Show InChI InChI=1S/C15H7F3N6O2/c16-15(17,18)14-23-12(24-26-14)10-6-21-11(7-20-10)22-13(25)9-3-1-8(5-19)2-4-9/h1-4,6-7H,(H,21,22,25)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM188028
PNG
(US9670193, 44 (R)?N-(Pyridin-4-yl)ethyl)-5-(5-trif...)
Show SMILES C[C@@H](Nc1ccc(cn1)-c1noc(n1)C(F)(F)F)c1ccncc1
Show InChI InChI=1S/C15H12F3N5O/c1-9(10-4-6-19-7-5-10)21-12-3-2-11(8-20-12)13-22-14(24-23-13)15(16,17)18/h2-9H,1H3,(H,20,21)/t9-/m1/s1
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187610
PNG
(US9670193, 27 N-benzyl-6-(5-(trifluoromethyl)-1,2,...)
Show SMILES FC(F)(F)c1nc(no1)-c1ccc(NCc2ccccc2)cn1
Show InChI InChI=1S/C15H11F3N4O/c16-15(17,18)14-21-13(22-23-14)12-7-6-11(9-20-12)19-8-10-4-2-1-3-5-10/h1-7,9,19H,8H2
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n/an/a 2.80E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187218
PNG
(US9670193, 8 N-((6-methylpyridin-3-yl)methyl)-5-(5...)
Show SMILES Cc1ccc(CNc2ncc(cn2)-c2noc(n2)C(F)(F)F)cn1
Show InChI InChI=1S/C14H11F3N6O/c1-8-2-3-9(4-18-8)5-19-13-20-6-10(7-21-13)11-22-12(24-23-11)14(15,16)17/h2-4,6-7H,5H2,1H3,(H,19,20,21)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187617
PNG
(US9670193, 28 N-benzyl-5-(5-(trifluoromethyl)-1,2,...)
Show SMILES FC(F)(F)c1nc(no1)-c1ccc(NCc2ccccc2)nc1
Show InChI InChI=1S/C15H11F3N4O/c16-15(17,18)14-21-13(22-23-14)11-6-7-12(20-9-11)19-8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H,19,20)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187187
PNG
(US9670193, 3 N-methyl-N-(pyridin-4-ylmethyl)-5-(5-...)
Show SMILES CN(Cc1ccncc1)c1ncc(cn1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C14H11F3N6O/c1-23(8-9-2-4-18-5-3-9)13-19-6-10(7-20-13)11-21-12(24-22-11)14(15,16)17/h2-7H,8H2,1H3
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM188029
PNG
(US9670193, 45 (R)?N-(1-(Pyridin-4-yl)ethyl)-6-(5-(...)
Show SMILES C[C@@H](Nc1ccc(nn1)-c1noc(n1)C(F)(F)F)c1ccncc1
Show InChI InChI=1S/C14H11F3N6O/c1-8(9-4-6-18-7-5-9)19-11-3-2-10(21-22-11)12-20-13(24-23-12)14(15,16)17/h2-8H,1H3,(H,19,22)/t8-/m1/s1
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187244
PNG
(US9670193, 17 N-methyl-N-((2-methylpyridin-4-yl)me...)
Show SMILES CN(Cc1ccnc(C)c1)c1ncc(cn1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C15H13F3N6O/c1-9-5-10(3-4-19-9)8-24(2)14-20-6-11(7-21-14)12-22-13(25-23-12)15(16,17)18/h3-7H,8H2,1-2H3
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187222
PNG
(US9670193, 12 (R)?N-(1-phenylethyl)-5-(5-(trifluor...)
Show SMILES C[C@@H](Nc1ncc(cn1)-c1noc(n1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C15H12F3N5O/c1-9(10-5-3-2-4-6-10)21-14-19-7-11(8-20-14)12-22-13(24-23-12)15(16,17)18/h2-9H,1H3,(H,19,20,21)/t9-/m1/s1
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187569
PNG
(US9670193, 25 (R)-3-chloro-N-(1-(dimethylamino)pro...)
Show SMILES C[C@H](CN(C)C)NC(=O)c1ncc(cc1Cl)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C14H15ClF3N5O2/c1-7(6-23(2)3)20-12(24)10-9(15)4-8(5-19-10)11-21-13(25-22-11)14(16,17)18/h4-5,7H,6H2,1-3H3,(H,20,24)/t7-/m1/s1
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n/an/a 3.60E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM188006
PNG
(US9670193, 41 (R)?N-(1-Phenylethyl)-2-(5-(trifluor...)
Show SMILES C[C@@H](Nc1cnc(nc1)-c1noc(n1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C15H12F3N5O/c1-9(10-5-3-2-4-6-10)21-11-7-19-12(20-8-11)13-22-14(24-23-13)15(16,17)18/h2-9,21H,1H3/t9-/m1/s1
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187219
PNG
(US9670193, 9 N-(1-(pyridin-4-yl)ethyl)-5-(5-(trifl...)
Show SMILES CC(Nc1ncc(cn1)-c1noc(n1)C(F)(F)F)c1ccncc1
Show InChI InChI=1S/C14H11F3N6O/c1-8(9-2-4-18-5-3-9)21-13-19-6-10(7-20-13)11-22-12(24-23-11)14(15,16)17/h2-8H,1H3,(H,19,20,21)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM187399
PNG
(US9670193, 20 (S)?N-(1-hydroxypropan-2-yl)-6-(5-(t...)
Show SMILES C[C@@H](CO)NC(=O)c1ccc(nc1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C12H11F3N4O3/c1-6(5-20)17-10(21)7-2-3-8(16-4-7)9-18-11(22-19-9)12(13,14)15/h2-4,6,20H,5H2,1H3,(H,17,21)/t6-/m0/s1
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n/an/a 4.30E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187642
PNG
(US9670193, 34 (R)-3-chloro-N-(1-phenylethyl)-5-(5-...)
Show SMILES C[C@@H](Nc1ncc(cc1Cl)-c1noc(n1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C16H12ClF3N4O/c1-9(10-5-3-2-4-6-10)22-14-12(17)7-11(8-21-14)13-23-15(25-24-13)16(18,19)20/h2-9H,1H3,(H,21,22)/t9-/m1/s1
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187638
PNG
(US9670193, 31 N-(pyridin-4-ylmethyl)-5-(5-(trifluo...)
Show SMILES FC(F)(F)c1nc(no1)-c1ccc(NCc2ccncc2)nc1
Show InChI InChI=1S/C14H10F3N5O/c15-14(16,17)13-21-12(22-23-13)10-1-2-11(20-8-10)19-7-9-3-5-18-6-4-9/h1-6,8H,7H2,(H,19,20)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM188027
PNG
(US9670193, 43 N-(Pyridin-4-ylmethyl)-2-(5-(trifluo...)
Show SMILES FC(F)(F)c1nc(no1)-c1ncc(NCc2ccncc2)cn1
Show InChI InChI=1S/C13H9F3N6O/c14-13(15,16)12-21-11(22-23-12)10-19-6-9(7-20-10)18-5-8-1-3-17-4-2-8/h1-4,6-7,18H,5H2
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
HDAC4 (aa 2-1084)


(Homo sapiens (Human))
BDBM188008
PNG
(US9670193, 42 (S)?N-(1-Phenylethyl)-2-(5-(trifluor...)
Show SMILES C[C@H](Nc1cnc(nc1)-c1noc(n1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C15H12F3N5O/c1-9(10-5-3-2-4-6-10)21-11-7-19-12(20-8-11)13-22-14(24-23-13)15(16,17)18/h2-9,21H,1H3/t9-/m0/s1
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n/an/a 5.00E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187629
PNG
(US9670193, 30 N-(pyridin-3-ylmethyl)-5-(5-(trifluo...)
Show SMILES FC(F)(F)c1nc(no1)-c1ccc(NCc2cccnc2)nc1
Show InChI InChI=1S/C14H10F3N5O/c15-14(16,17)13-21-12(22-23-13)10-3-4-11(20-8-10)19-7-9-2-1-5-18-6-9/h1-6,8H,7H2,(H,19,20)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187628
PNG
(US9670193, 29 N-(1-phenylethyl)-5-(5-(trifluoromet...)
Show SMILES CC(Nc1ccc(cn1)-c1noc(n1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C16H13F3N4O/c1-10(11-5-3-2-4-6-11)21-13-8-7-12(9-20-13)14-22-15(24-23-14)16(17,18)19/h2-10H,1H3,(H,20,21)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187642
PNG
(US9670193, 34 (R)-3-chloro-N-(1-phenylethyl)-5-(5-...)
Show SMILES C[C@@H](Nc1ncc(cc1Cl)-c1noc(n1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C16H12ClF3N4O/c1-9(10-5-3-2-4-6-10)22-14-12(17)7-11(8-21-14)13-23-15(25-24-13)16(18,19)20/h2-9H,1H3,(H,21,22)/t9-/m1/s1
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187220
PNG
(US9670193, 10 N-(pyridin-3-ylmethyl)-5-(5-(trifluo...)
Show SMILES FC(F)(F)c1nc(no1)-c1cnc(NCc2cccnc2)nc1
Show InChI InChI=1S/C13H9F3N6O/c14-13(15,16)11-21-10(22-23-11)9-6-19-12(20-7-9)18-5-8-2-1-3-17-4-8/h1-4,6-7H,5H2,(H,18,19,20)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187187
PNG
(US9670193, 3 N-methyl-N-(pyridin-4-ylmethyl)-5-(5-...)
Show SMILES CN(Cc1ccncc1)c1ncc(cn1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C14H11F3N6O/c1-23(8-9-2-4-18-5-3-9)13-19-6-10(7-20-13)11-21-12(24-22-11)14(15,16)17/h2-7H,8H2,1H3
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187224
PNG
(US9670193, 14 N-methyl-N-(2-(pyridin-4-yl)ethyl)-5...)
Show SMILES CN(CCc1ccncc1)c1ncc(cn1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C15H13F3N6O/c1-24(7-4-10-2-5-19-6-3-10)14-20-8-11(9-21-14)12-22-13(25-23-12)15(16,17)18/h2-3,5-6,8-9H,4,7H2,1H3
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187993
PNG
(US9670193, 40 N-benzyl-6-(5-(trifluoromethyl)-1,2,...)
Show SMILES FC(F)(F)c1nc(no1)-c1ccc(NCc2ccccc2)nn1
Show InChI InChI=1S/C14H10F3N5O/c15-14(16,17)13-19-12(22-23-13)10-6-7-11(21-20-10)18-8-9-4-2-1-3-5-9/h1-7H,8H2,(H,18,21)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187610
PNG
(US9670193, 27 N-benzyl-6-(5-(trifluoromethyl)-1,2,...)
Show SMILES FC(F)(F)c1nc(no1)-c1ccc(NCc2ccccc2)cn1
Show InChI InChI=1S/C15H11F3N4O/c16-15(17,18)14-21-13(22-23-14)12-7-6-11(9-20-12)19-8-10-4-2-1-3-5-10/h1-7,9,19H,8H2
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187177
PNG
(US9670193, 2 4-Cyano-N-(5-(5-(trifluoromethyl)-1,2...)
Show SMILES FC(F)(F)c1nc(no1)-c1cnc(NC(=O)c2ccc(cc2)C#N)cn1
Show InChI InChI=1S/C15H7F3N6O2/c16-15(17,18)14-23-12(24-26-14)10-6-21-11(7-20-10)22-13(25)9-3-1-8(5-19)2-4-9/h1-4,6-7H,(H,21,22,25)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187565
PNG
(US9670193, 23 (R)?N-(1-(diethylamino)propan-2-yl)-...)
Show SMILES CCN(CC)C[C@@H](C)NC(=O)c1ccc(nc1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C16H20F3N5O2/c1-4-24(5-2)9-10(3)21-14(25)11-6-7-12(20-8-11)13-22-15(26-23-13)16(17,18)19/h6-8,10H,4-5,9H2,1-3H3,(H,21,25)/t10-/m1/s1
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187617
PNG
(US9670193, 28 N-benzyl-5-(5-(trifluoromethyl)-1,2,...)
Show SMILES FC(F)(F)c1nc(no1)-c1ccc(NCc2ccccc2)nc1
Show InChI InChI=1S/C15H11F3N4O/c16-15(17,18)14-21-13(22-23-14)11-6-7-12(20-9-11)19-8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H,19,20)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM188075
PNG
(US9670193, 46 (R)?N-(1-(benzyl(methyl)amino)propan...)
Show SMILES C[C@H](CN(C)Cc1ccccc1)NC(=O)c1cnc(nc1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C19H19F3N6O2/c1-12(10-28(2)11-13-6-4-3-5-7-13)25-17(29)14-8-23-15(24-9-14)16-26-18(30-27-16)19(20,21)22/h3-9,12H,10-11H2,1-2H3,(H,25,29)/t12-/m1/s1
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187138
PNG
(US9670193, 1 N-(5-(5-(trifluoromethyl)-1,2,4-oxadi...)
Show SMILES CC(=O)Nc1cnc(cn1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C9H6F3N5O2/c1-4(18)15-6-3-13-5(2-14-6)7-16-8(19-17-7)9(10,11)12/h2-3H,1H3,(H,14,15,18)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187217
PNG
(US9670193, 7 N-(1-phenylethyl)-5-(5-(trifluorometh...)
Show SMILES CC(Nc1ncc(cn1)-c1noc(n1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C15H12F3N5O/c1-9(10-5-3-2-4-6-10)21-14-19-7-11(8-20-14)12-22-13(24-23-12)15(16,17)18/h2-9H,1H3,(H,19,20,21)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187224
PNG
(US9670193, 14 N-methyl-N-(2-(pyridin-4-yl)ethyl)-5...)
Show SMILES CN(CCc1ccncc1)c1ncc(cn1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C15H13F3N6O/c1-24(7-4-10-2-5-19-6-3-10)14-20-8-11(9-21-14)12-22-13(25-23-12)15(16,17)18/h2-3,5-6,8-9H,4,7H2,1H3
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187543
PNG
(US9670193, 21 (R)?N-(1-(benzyl(methyl)amino)propan...)
Show SMILES C[C@H](CN(C)Cc1ccccc1)NC(=O)c1ccc(nc1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C20H20F3N5O2/c1-13(11-28(2)12-14-6-4-3-5-7-14)25-18(29)15-8-9-16(24-10-15)17-26-19(30-27-17)20(21,22)23/h3-10,13H,11-12H2,1-2H3,(H,25,29)/t13-/m1/s1
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187547
PNG
(US9670193, 22 (R)?N-(1-(diethylamino)-3-methylbuta...)
Show SMILES CCN(CC)C[C@H](NC(=O)c1ccc(nc1)-c1noc(n1)C(F)(F)F)C(C)C
Show InChI InChI=1S/C18H24F3N5O2/c1-5-26(6-2)10-14(11(3)4)23-16(27)12-7-8-13(22-9-12)15-24-17(28-25-15)18(19,20)21/h7-9,11,14H,5-6,10H2,1-4H3,(H,23,27)/t14-/m0/s1
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187566
PNG
(US9670193, 24 (R)?N-(1-(dimethylamino)propan-2-yl)...)
Show SMILES C[C@H](CN(C)C)NC(=O)c1ccc(cn1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C14H16F3N5O2/c1-8(7-22(2)3)19-12(23)10-5-4-9(6-18-10)11-20-13(24-21-11)14(15,16)17/h4-6,8H,7H2,1-3H3,(H,19,23)/t8-/m1/s1
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187604
PNG
(US9670193, 26 (R)?N-(1-(dimethylamino)propan-2-yl)...)
Show SMILES C[C@H](CN(C)C)NC(=O)c1cnc(nc1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C13H15F3N6O2/c1-7(6-22(2)3)19-11(23)8-4-17-9(18-5-8)10-20-12(24-21-10)13(14,15)16/h4-5,7H,6H2,1-3H3,(H,19,23)/t7-/m1/s1
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187543
PNG
(US9670193, 21 (R)?N-(1-(benzyl(methyl)amino)propan...)
Show SMILES C[C@H](CN(C)Cc1ccccc1)NC(=O)c1ccc(nc1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C20H20F3N5O2/c1-13(11-28(2)12-14-6-4-3-5-7-14)25-18(29)15-8-9-16(24-10-15)17-26-19(30-27-17)20(21,22)23/h3-10,13H,11-12H2,1-2H3,(H,25,29)/t13-/m1/s1
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187547
PNG
(US9670193, 22 (R)?N-(1-(diethylamino)-3-methylbuta...)
Show SMILES CCN(CC)C[C@H](NC(=O)c1ccc(nc1)-c1noc(n1)C(F)(F)F)C(C)C
Show InChI InChI=1S/C18H24F3N5O2/c1-5-26(6-2)10-14(11(3)4)23-16(27)12-7-8-13(22-9-12)15-24-17(28-25-15)18(19,20)21/h7-9,11,14H,5-6,10H2,1-4H3,(H,23,27)/t14-/m0/s1
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187569
PNG
(US9670193, 25 (R)-3-chloro-N-(1-(dimethylamino)pro...)
Show SMILES C[C@H](CN(C)C)NC(=O)c1ncc(cc1Cl)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C14H15ClF3N5O2/c1-7(6-23(2)3)20-12(24)10-9(15)4-8(5-19-10)11-21-13(25-22-11)14(16,17)18/h4-5,7H,6H2,1-3H3,(H,20,24)/t7-/m1/s1
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187610
PNG
(US9670193, 27 N-benzyl-6-(5-(trifluoromethyl)-1,2,...)
Show SMILES FC(F)(F)c1nc(no1)-c1ccc(NCc2ccccc2)cn1
Show InChI InChI=1S/C15H11F3N4O/c16-15(17,18)14-21-13(22-23-14)12-7-6-11(9-20-12)19-8-10-4-2-1-3-5-10/h1-7,9,19H,8H2
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187640
PNG
(US9670193, 33 N-benzyl-3-chloro-5-(5-(trifluoromet...)
Show SMILES FC(F)(F)c1nc(no1)-c1cnc(NCc2ccccc2)c(Cl)c1
Show InChI InChI=1S/C15H10ClF3N4O/c16-11-6-10(12-22-14(24-23-12)15(17,18)19)8-21-13(11)20-7-9-4-2-1-3-5-9/h1-6,8H,7H2,(H,20,21)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187246
PNG
(US9670193, 18 (R)?N-(1-(dimethylamino)propan-2-yl)...)
Show SMILES C[C@H](CN(C)C)NC(=O)c1ccc(nc1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C14H16F3N5O2/c1-8(7-22(2)3)19-12(23)9-4-5-10(18-6-9)11-20-13(24-21-11)14(15,16)17/h4-6,8H,7H2,1-3H3,(H,19,23)/t8-/m1/s1
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187246
PNG
(US9670193, 18 (R)?N-(1-(dimethylamino)propan-2-yl)...)
Show SMILES C[C@H](CN(C)C)NC(=O)c1ccc(nc1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C14H16F3N5O2/c1-8(7-22(2)3)19-12(23)9-4-5-10(18-6-9)11-20-13(24-21-11)14(15,16)17/h4-6,8H,7H2,1-3H3,(H,19,23)/t8-/m1/s1
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187307
PNG
(US9670193, 19 N-(1-(dimethylamino)propan-2-yl)-6-(...)
Show SMILES CC(CN(C)C)NC(=O)c1ccc(nc1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C14H16F3N5O2/c1-8(7-22(2)3)19-12(23)9-4-5-10(18-6-9)11-20-13(24-21-11)14(15,16)17/h4-6,8H,7H2,1-3H3,(H,19,23)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187399
PNG
(US9670193, 20 (S)?N-(1-hydroxypropan-2-yl)-6-(5-(t...)
Show SMILES C[C@@H](CO)NC(=O)c1ccc(nc1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C12H11F3N4O3/c1-6(5-20)17-10(21)7-2-3-8(16-4-7)9-18-11(22-19-9)12(13,14)15/h2-4,6,20H,5H2,1H3,(H,17,21)/t6-/m0/s1
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187566
PNG
(US9670193, 24 (R)?N-(1-(dimethylamino)propan-2-yl)...)
Show SMILES C[C@H](CN(C)C)NC(=O)c1ccc(cn1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C14H16F3N5O2/c1-8(7-22(2)3)19-12(23)10-5-4-9(6-18-10)11-20-13(24-21-11)14(15,16)17/h4-6,8H,7H2,1-3H3,(H,19,23)/t8-/m1/s1
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM188008
PNG
(US9670193, 42 (S)?N-(1-Phenylethyl)-2-(5-(trifluor...)
Show SMILES C[C@H](Nc1cnc(nc1)-c1noc(n1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C15H12F3N5O/c1-9(10-5-3-2-4-6-10)21-11-7-19-12(20-8-11)13-22-14(24-23-13)15(16,17)18/h2-9,21H,1H3/t9-/m0/s1
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187213
PNG
(US9670193, 4 N-benzyl-5-(5-(trifluoromethyl)-1,2,4...)
Show SMILES FC(F)(F)c1nc(no1)-c1cnc(NCc2ccccc2)nc1
Show InChI InChI=1S/C14H10F3N5O/c15-14(16,17)12-21-11(22-23-12)10-7-19-13(20-8-10)18-6-9-4-2-1-3-5-9/h1-5,7-8H,6H2,(H,18,19,20)
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187565
PNG
(US9670193, 23 (R)?N-(1-(diethylamino)propan-2-yl)-...)
Show SMILES CCN(CC)C[C@@H](C)NC(=O)c1ccc(nc1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C16H20F3N5O2/c1-4-24(5-2)9-10(3)21-14(25)11-6-7-12(20-8-11)13-22-15(26-23-13)16(17,18)19/h6-8,10H,4-5,9H2,1-3H3,(H,21,25)/t10-/m1/s1
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187569
PNG
(US9670193, 25 (R)-3-chloro-N-(1-(dimethylamino)pro...)
Show SMILES C[C@H](CN(C)C)NC(=O)c1ncc(cc1Cl)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C14H15ClF3N5O2/c1-7(6-23(2)3)20-12(24)10-9(15)4-8(5-19-10)11-21-13(25-22-11)14(16,17)18/h4-5,7H,6H2,1-3H3,(H,20,24)/t7-/m1/s1
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Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187640
PNG
(US9670193, 33 N-benzyl-3-chloro-5-(5-(trifluoromet...)
Show SMILES FC(F)(F)c1nc(no1)-c1cnc(NCc2ccccc2)c(Cl)c1
Show InChI InChI=1S/C15H10ClF3N4O/c16-11-6-10(12-22-14(24-23-12)15(17,18)19)8-21-13(11)20-7-9-4-2-1-3-5-9/h1-6,8H,7H2,(H,20,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


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Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM188075
PNG
(US9670193, 46 (R)?N-(1-(benzyl(methyl)amino)propan...)
Show SMILES C[C@H](CN(C)Cc1ccccc1)NC(=O)c1cnc(nc1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C19H19F3N6O2/c1-12(10-28(2)11-13-6-4-3-5-7-13)25-17(29)14-8-23-15(24-9-14)16-26-18(30-27-16)19(20,21)22/h3-9,12H,10-11H2,1-2H3,(H,25,29)/t12-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM187399
PNG
(US9670193, 20 (S)?N-(1-hydroxypropan-2-yl)-6-(5-(t...)
Show SMILES C[C@@H](CO)NC(=O)c1ccc(nc1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C12H11F3N4O3/c1-6(5-20)17-10(21)7-2-3-8(16-4-7)9-18-11(22-19-9)12(13,14)15/h2-4,6,20H,5H2,1H3,(H,17,21)/t6-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM187604
PNG
(US9670193, 26 (R)?N-(1-(dimethylamino)propan-2-yl)...)
Show SMILES C[C@H](CN(C)C)NC(=O)c1cnc(nc1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C13H15F3N6O2/c1-7(6-22(2)3)19-11(23)8-4-17-9(18-5-8)10-20-12(24-21-10)13(14,15)16/h4-5,7H,6H2,1-3H3,(H,19,23)/t7-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%