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Patent code US9670196

Compile Data Set for Download or QSAR
Found 13 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM189867
PNG
(US9670196, 2.3 (R or S)-5-hydroxy-5-{5-[3- methyl-...)
Show SMILES Cc1cc(Nc2nc3ccccn3n2)cc(c1)-c1cnc(s1)[C@@]1(O)CCCc2cc(ccc12)C(O)=O
Show InChI InChI=1S/C27H23N5O3S/c1-16-11-19(14-20(12-16)29-26-30-23-6-2-3-10-32(23)31-26)22-15-28-25(36-22)27(35)9-4-5-17-13-18(24(33)34)7-8-21(17)27/h2-3,6-8,10-15,35H,4-5,9H2,1H3,(H,29,31)(H,33,34)/t27-/m1/s1
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n/an/a 0.129n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9670196 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM189868
PNG
(US9670196, 2.4 1-hydroxy-1-{5-[3-methyl- 5-([1,2,4...)
Show SMILES Cc1cc(Nc2nc3ccccn3n2)cc(c1)-c1cnc(s1)C1(O)CCc2cc(ccc12)C(O)=O
Show InChI InChI=1S/C26H21N5O3S/c1-15-10-18(13-19(11-15)28-25-29-22-4-2-3-9-31(22)30-25)21-14-27-24(35-21)26(34)8-7-16-12-17(23(32)33)5-6-20(16)26/h2-6,9-14,34H,7-8H2,1H3,(H,28,30)(H,32,33)
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n/an/a 1.01n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9670196 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM189869
PNG
(US9670196, 2.5 (R or S)-4-(1-hydroxy-1-{5- [3-meth...)
Show SMILES Cc1cc(Nc2nc3ccccn3n2)cc(c1)-c1cnc(s1)C(C)(O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H21N5O3S/c1-15-11-17(13-19(12-15)27-24-28-21-5-3-4-10-30(21)29-24)20-14-26-23(34-20)25(2,33)18-8-6-16(7-9-18)22(31)32/h3-14,33H,1-2H3,(H,27,29)(H,31,32)
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n/an/a 1.17n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9670196 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM189864
PNG
(US9670196, 2.1 4-((5-(3-([1,2,4]triazolo[1,5-a]pyr...)
Show SMILES Cc1cc(Nc2nc3ccccn3n2)cc(c1)-c1cnc(Cc2ccc(cc2)C(O)=O)s1
Show InChI InChI=1S/C24H19N5O2S/c1-15-10-18(13-19(11-15)26-24-27-21-4-2-3-9-29(21)28-24)20-14-25-22(32-20)12-16-5-7-17(8-6-16)23(30)31/h2-11,13-14H,12H2,1H3,(H,26,28)(H,30,31)
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n/an/a 2.44n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9670196 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM189862
PNG
(US9670196, 1.6 4-(1-(5-(6-((1H- pyrrolo[2,3-b]pyri...)
Show SMILES Cc1cc(Nc2ccc3cc[nH]c3n2)nc(c1)-c1cnc(s1)C(C)(O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H21N5O3S/c1-14-11-18(28-21(12-14)29-20-8-5-15-9-10-26-22(15)30-20)19-13-27-24(34-19)25(2,33)17-6-3-16(4-7-17)23(31)32/h3-13,33H,1-2H3,(H,31,32)(H2,26,28,29,30)
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n/an/a 5.40n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9670196 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM189859
PNG
(US9670196, 1.4 (R or S)-5-hydroxy-5-(5- (6-((2-met...)
Show SMILES COc1ccc2cc(Nc3cc(C)cc(n3)-c3cnc(s3)C3(O)CCCC4C=C(C=CC34)C(O)=O)ncc2n1
Show InChI InChI=1S/C29H27N5O4S/c1-16-10-21(32-25(11-16)34-24-13-18-6-8-26(38-2)33-22(18)14-30-24)23-15-31-28(39-23)29(37)9-3-4-17-12-19(27(35)36)5-7-20(17)29/h5-8,10-15,17,20,37H,3-4,9H2,1-2H3,(H,35,36)(H,30,32,34)
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n/an/a 5.50n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9670196 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM189869
PNG
(US9670196, 2.5 (R or S)-4-(1-hydroxy-1-{5- [3-meth...)
Show SMILES Cc1cc(Nc2nc3ccccn3n2)cc(c1)-c1cnc(s1)C(C)(O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H21N5O3S/c1-15-11-17(13-19(12-15)27-24-28-21-5-3-4-10-30(21)29-24)20-14-26-23(34-20)25(2,33)18-8-6-16(7-9-18)22(31)32/h3-14,33H,1-2H3,(H,27,29)(H,31,32)
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n/an/a 6.47n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9670196 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM189861
PNG
(US9670196, 1.5 4-(1-(5-(6-(furo[3,2- b]pyridin-5-y...)
Show SMILES Cc1cc(Nc2ccc3occc3n2)nc(c1)-c1cnc(s1)C(C)(O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H20N4O4S/c1-14-11-18(28-22(12-14)29-21-8-7-19-17(27-21)9-10-33-19)20-13-26-24(34-20)25(2,32)16-5-3-15(4-6-16)23(30)31/h3-13,32H,1-2H3,(H,30,31)(H,27,28,29)
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n/an/a 11.7n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9670196 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM189863
PNG
(US9670196, 1.7 (1S,4R or 1R,4S)-4- hydroxy-2,2-dim...)
Show SMILES Cc1cc(Nc2nc(C)c3occc3n2)cc(c1)-c1cnc(s1)[C@@]1(O)CC[C@H](C(O)=O)C(C)(C)C1
Show InChI InChI=1S/C26H28N4O4S/c1-14-9-16(11-17(10-14)29-24-28-15(2)21-19(30-24)6-8-34-21)20-12-27-23(35-20)26(33)7-5-18(22(31)32)25(3,4)13-26/h6,8-12,18,33H,5,7,13H2,1-4H3,(H,31,32)(H,28,29,30)/t18-,26-/m1/s1
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n/an/a 13.2n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9670196 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM189857
PNG
(US9670196, 1.2 (1S,4R or 1R,4S)-4-(5-(3-((6,7-dihy...)
Show SMILES Cc1cc(Nc2ncc3CCCc3n2)cc(c1)-c1cnc(s1)[C@@]1(O)CC[C@H](C(O)=O)C(C)(C)C1
Show InChI InChI=1S/C26H30N4O3S/c1-15-9-17(11-18(10-15)29-24-28-12-16-5-4-6-20(16)30-24)21-13-27-23(34-21)26(33)8-7-19(22(31)32)25(2,3)14-26/h9-13,19,33H,4-8,14H2,1-3H3,(H,31,32)(H,28,29,30)/t19-,26-/m1/s1
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n/an/a 17.0n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9670196 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM189856
PNG
(US9670196, 1.1 (1S,4R or 1R,4S)-methyl 4-(5-(3-((6...)
Show SMILES Cc1cc(Nc2ncc3CCCc3n2)cc(c1)-c1cnc(s1)[C@]1(O)CC[C@@H](C(O)=O)C(C)(C)C1
Show InChI InChI=1S/C26H30N4O3S/c1-15-9-17(11-18(10-15)29-24-28-12-16-5-4-6-20(16)30-24)21-13-27-23(34-21)26(33)8-7-19(22(31)32)25(2,3)14-26/h9-13,19,33H,4-8,14H2,1-3H3,(H,31,32)(H,28,29,30)/t19-,26-/m0/s1
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n/an/a 412n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9670196 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM189866
PNG
(US9670196, 2.2 (1S,4R or 1R,4S)-4- hydroxy-2,2-dim...)
Show SMILES Cc1cc(Nc2nc(C)cc3cccnc23)cc(c1)-c1cnc(s1)[C@@]1(O)CCC(C(O)=O)C(C)(C)C1
Show InChI InChI=1S/C28H30N4O3S/c1-16-10-19(13-20(11-16)32-24-23-18(6-5-9-29-23)12-17(2)31-24)22-14-30-26(36-22)28(35)8-7-21(25(33)34)27(3,4)15-28/h5-6,9-14,21,35H,7-8,15H2,1-4H3,(H,31,32)(H,33,34)/t21?,28-/m1/s1
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n/an/a 2.33E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9670196 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM189858
PNG
(US9670196, 1.3 1,1,1-trifluoro-2-{5-[3- methyl-5-(...)
Show SMILES Cc1cc(Nc2ncnc3ccsc23)cc(c1)-c1cnc(s1)[C@](C)(O)C(F)(F)F
Show InChI InChI=1S/C19H15F3N4OS2/c1-10-5-11(14-8-23-17(29-14)18(2,27)19(20,21)22)7-12(6-10)26-16-15-13(3-4-28-15)24-9-25-16/h3-9,27H,1-2H3,(H,24,25,26)/t18-/m0/s1
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n/an/a 5.82E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9670196 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%