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Patent code US9670203

Compile Data Set for Download or QSAR
Found 142 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM186829
PNG
(US9670203, Compound 1.21)
Show SMILES Fc1ccccc1NC(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
Show InChI InChI=1S/C24H19FN4O4/c25-15-3-1-2-4-16(15)27-24(31)29-21-20-14-11-12(5-7-17(14)33-22(20)21)32-18-9-10-26-23-13(18)6-8-19(30)28-23/h1-5,7,9-11,20-22H,6,8H2,(H,26,28,30)(H2,27,29,31)/t20-,21-,22-/m0/s1
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n/an/a 66n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM188335
PNG
(US9670203, Compound 1.41)
Show SMILES Fc1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc1
Show InChI InChI=1S/C24H19FN4O4/c25-12-1-3-13(4-2-12)27-24(31)29-21-20-16-11-14(5-7-17(16)33-22(20)21)32-18-9-10-26-23-15(18)6-8-19(30)28-23/h1-5,7,9-11,20-22H,6,8H2,(H,26,28,30)(H2,27,29,31)/t20-,21-,22-/m0/s1
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n/an/a 150n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM186830
PNG
(US9670203, Compound 1.22 | US9670203, Compound 1.5...)
Show SMILES Fc1cccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1
Show InChI InChI=1S/C24H19FN4O4/c25-12-2-1-3-13(10-12)27-24(31)29-21-20-16-11-14(4-6-17(16)33-22(20)21)32-18-8-9-26-23-15(18)5-7-19(30)28-23/h1-4,6,8-11,20-22H,5,7H2,(H,26,28,30)(H2,27,29,31)/t20-,21-,22-/m0/s1
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n/an/a 180n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM189734
PNG
(US9670203, Compound 1.49)
Show SMILES Fc1cc(F)c(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc1F
Show InChI InChI=1S/C24H17F3N4O4/c25-13-8-15(27)16(9-14(13)26)29-24(33)31-21-20-12-7-10(1-3-17(12)35-22(20)21)34-18-5-6-28-23-11(18)2-4-19(32)30-23/h1,3,5-9,20-22H,2,4H2,(H,28,30,32)(H2,29,31,33)/t20-,21-,22-/m0/s1
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n/an/a 190n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM188334
PNG
(US9670203, Compound 1.40)
Show SMILES Fc1cc(F)c(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c(F)c1
Show InChI InChI=1S/C24H17F3N4O4/c25-10-7-14(26)20(15(27)8-10)30-24(33)31-21-19-13-9-11(1-3-16(13)35-22(19)21)34-17-5-6-28-23-12(17)2-4-18(32)29-23/h1,3,5-9,19,21-22H,2,4H2,(H,28,29,32)(H2,30,31,33)/t19-,21-,22-/m0/s1
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n/an/a 200n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM189299
PNG
(US9670203, Compound 1.44)
Show SMILES Fc1cccc(F)c1NC(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
Show InChI InChI=1S/C24H18F2N4O4/c25-14-2-1-3-15(26)20(14)29-24(32)30-21-19-13-10-11(4-6-16(13)34-22(19)21)33-17-8-9-27-23-12(17)5-7-18(31)28-23/h1-4,6,8-10,19,21-22H,5,7H2,(H,27,28,31)(H2,29,30,32)/t19-,21-,22-/m0/s1
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n/an/a 210n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM189302
PNG
(US9670203, Compound 1.46)
Show SMILES Fc1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c(F)c1F
Show InChI InChI=1S/C24H17F3N4O4/c25-13-3-4-14(20(27)19(13)26)29-24(33)31-21-18-12-9-10(1-5-15(12)35-22(18)21)34-16-7-8-28-23-11(16)2-6-17(32)30-23/h1,3-5,7-9,18,21-22H,2,6H2,(H,28,30,32)(H2,29,31,33)/t18-,21-,22-/m0/s1
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n/an/a 220n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM188336
PNG
(US9670203, Compound 1.42)
Show SMILES Fc1cccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1F
Show InChI InChI=1S/C24H18F2N4O4/c25-14-2-1-3-15(20(14)26)28-24(32)30-21-19-13-10-11(4-6-16(13)34-22(19)21)33-17-8-9-27-23-12(17)5-7-18(31)29-23/h1-4,6,8-10,19,21-22H,5,7H2,(H,27,29,31)(H2,28,30,32)/t19-,21-,22-/m0/s1
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n/an/a 240n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM188175
PNG
(US9670203, Compound 1.35)
Show SMILES Fc1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c(F)c1
Show InChI InChI=1S/C24H18F2N4O4/c25-11-1-4-16(15(26)9-11)28-24(32)30-21-20-14-10-12(2-5-17(14)34-22(20)21)33-18-7-8-27-23-13(18)3-6-19(31)29-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,27,29,31)(H2,28,30,32)/t20-,21-,22-/m0/s1
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n/an/a 250n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM189930
PNG
(US9670203, Compound 1.66)
Show SMILES O=C(N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12)NC1CCCCC1
Show InChI InChI=1S/C24H26N4O4/c29-19-9-7-15-18(10-11-25-23(15)27-19)31-14-6-8-17-16(12-14)20-21(22(20)32-17)28-24(30)26-13-4-2-1-3-5-13/h6,8,10-13,20-22H,1-5,7,9H2,(H,25,27,29)(H2,26,28,30)/t20-,21-,22-/m0/s1
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n/an/a 250n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM189824
PNG
(US9670203, Compound 1.52)
Show SMILES O=C(N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12)NC1CCCCCC1
Show InChI InChI=1S/C25H28N4O4/c30-20-10-8-16-19(11-12-26-24(16)28-20)32-15-7-9-18-17(13-15)21-22(23(21)33-18)29-25(31)27-14-5-3-1-2-4-6-14/h7,9,11-14,21-23H,1-6,8,10H2,(H,26,28,30)(H2,27,29,31)/t21-,22-,23-/m0/s1
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n/an/a 250n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM189294
PNG
(US9670203, Compound 1.43)
Show SMILES Fc1ccc(F)c(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1
Show InChI InChI=1S/C24H18F2N4O4/c25-11-1-4-15(26)16(9-11)28-24(32)30-21-20-14-10-12(2-5-17(14)34-22(20)21)33-18-7-8-27-23-13(18)3-6-19(31)29-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,27,29,31)(H2,28,30,32)/t20-,21-,22-/m0/s1
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n/an/a 260n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM190878
PNG
(US9670203, Compound 1.75 1-(2-methoxypyridin-4-yl)...)
Show SMILES COc1cc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)ccn1
Show InChI InChI=1S/C24H21N5O5/c1-32-19-10-12(6-8-25-19)27-24(31)29-21-20-15-11-13(2-4-16(15)34-22(20)21)33-17-7-9-26-23-14(17)3-5-18(30)28-23/h2,4,6-11,20-22H,3,5H2,1H3,(H,26,28,30)(H2,25,27,29,31)/t20-,21-,22-/m0/s1
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n/an/a 270n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM186831
PNG
(US9670203, Compound 1.23)
Show SMILES Fc1cc(F)cc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1
Show InChI InChI=1S/C24H18F2N4O4/c25-11-7-12(26)9-13(8-11)28-24(32)30-21-20-16-10-14(1-3-17(16)34-22(20)21)33-18-5-6-27-23-15(18)2-4-19(31)29-23/h1,3,5-10,20-22H,2,4H2,(H,27,29,31)(H2,28,30,32)/t20-,21-,22-/m0/s1
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n/an/a 300n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM189301
PNG
(US9670203, Compound 1.45)
Show SMILES Fc1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc1F
Show InChI InChI=1S/C24H18F2N4O4/c25-15-4-1-11(9-16(15)26)28-24(32)30-21-20-14-10-12(2-5-17(14)34-22(20)21)33-18-7-8-27-23-13(18)3-6-19(31)29-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,27,29,31)(H2,28,30,32)/t20-,21-,22-/m0/s1
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n/an/a 300n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM186814
PNG
(US9670203, Compound 1.6)
Show SMILES COc1cccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1Cl
Show InChI InChI=1S/C25H21ClN4O5/c1-33-18-4-2-3-15(21(18)26)28-25(32)30-22-20-14-11-12(5-7-16(14)35-23(20)22)34-17-9-10-27-24-13(17)6-8-19(31)29-24/h2-5,7,9-11,20,22-23H,6,8H2,1H3,(H,27,29,31)(H2,28,30,32)/t20-,22-,23-/m0/s1
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n/an/a 330n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM186323
PNG
(US9670203, Compound 1.1 1-((1S,1aS,6bS)-5-((7-oxo-...)
Show SMILES FC(F)(F)c1cccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1
Show InChI InChI=1S/C25H19F3N4O4/c26-25(27,28)12-2-1-3-13(10-12)30-24(34)32-21-20-16-11-14(4-6-17(16)36-22(20)21)35-18-8-9-29-23-15(18)5-7-19(33)31-23/h1-4,6,8-11,20-22H,5,7H2,(H,29,31,33)(H2,30,32,34)/t20-,21-,22-/m0/s1
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n/an/a 340n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM190858
PNG
(US9670203, Compound 1.71 1-((1R,1aR,6bR)-5-((7-oxo...)
Show SMILES FC(F)(F)c1cccc(NC(=O)N[C@H]2[C@@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@H]23)c1
Show InChI InChI=1S/C25H19F3N4O4/c26-25(27,28)12-2-1-3-13(10-12)30-24(34)32-21-20-16-11-14(4-6-17(16)36-22(20)21)35-18-8-9-29-23-15(18)5-7-19(33)31-23/h1-4,6,8-11,20-22H,5,7H2,(H,29,31,33)(H2,30,32,34)/t20-,21-,22-/m1/s1
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n/an/a 340n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM186815
PNG
(US9670203, Compound 1.7)
Show SMILES Cc1cc(Cl)ccc1NC(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
Show InChI InChI=1S/C25H21ClN4O4/c1-12-10-13(26)2-5-17(12)28-25(32)30-22-21-16-11-14(3-6-18(16)34-23(21)22)33-19-8-9-27-24-15(19)4-7-20(31)29-24/h2-3,5-6,8-11,21-23H,4,7H2,1H3,(H,27,29,31)(H2,28,30,32)/t21-,22-,23-/m0/s1
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n/an/a 350n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM186832
PNG
(US9670203, Compound 1.24)
Show SMILES Cc1cc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)ccc1F
Show InChI InChI=1S/C25H21FN4O4/c1-12-10-13(2-5-17(12)26)28-25(32)30-22-21-16-11-14(3-6-18(16)34-23(21)22)33-19-8-9-27-24-15(19)4-7-20(31)29-24/h2-3,5-6,8-11,21-23H,4,7H2,1H3,(H,27,29,31)(H2,28,30,32)/t21-,22-,23-/m0/s1
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n/an/a 370n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM190915
PNG
(US9670203, Compound 1.79)
Show SMILES O=C(N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12)N[C@H]1CCCc2ccccc12
Show InChI InChI=1S/C28H26N4O4/c33-23-11-9-18-22(12-13-29-27(18)31-23)35-16-8-10-21-19(14-16)24-25(26(24)36-21)32-28(34)30-20-7-3-5-15-4-1-2-6-17(15)20/h1-2,4,6,8,10,12-14,20,24-26H,3,5,7,9,11H2,(H,29,31,33)(H2,30,32,34)/t20-,24-,25-,26-/m0/s1
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n/an/a 390n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM190916
PNG
(US9670203, Compound 1.80)
Show SMILES O=C(N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12)N[C@@H]1CCCc2ccccc12
Show InChI InChI=1S/C28H26N4O4/c33-23-11-9-18-22(12-13-29-27(18)31-23)35-16-8-10-21-19(14-16)24-25(26(24)36-21)32-28(34)30-20-7-3-5-15-4-1-2-6-17(15)20/h1-2,4,6,8,10,12-14,20,24-26H,3,5,7,9,11H2,(H,29,31,33)(H2,30,32,34)/t20-,24+,25+,26+/m1/s1
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n/an/a 500n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM189357
PNG
(US9670203, Compound 1.47)
Show SMILES Fc1cc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc(F)c1F
Show InChI InChI=1S/C17H23NO2/c1-13-17(2,3)14-9-6-7-10-15(14)18(13)12-8-4-5-11-16(19)20/h6-7,9-10H,1,4-5,8,11-12H2,2-3H3,(H,19,20)
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n/an/a 530n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM186811
PNG
(US9670203, Compound 1.3)
Show SMILES COc1ccc(CNC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc1
Show InChI InChI=1S/C26H24N4O5/c1-33-15-4-2-14(3-5-15)13-28-26(32)30-23-22-18-12-16(6-8-19(18)35-24(22)23)34-20-10-11-27-25-17(20)7-9-21(31)29-25/h2-6,8,10-12,22-24H,7,9,13H2,1H3,(H,27,29,31)(H2,28,30,32)/t22-,23-,24-/m0/s1
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n/an/a 540n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM188175
PNG
(US9670203, Compound 1.35)
Show SMILES Fc1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c(F)c1
Show InChI InChI=1S/C24H18F2N4O4/c25-11-1-4-16(15(26)9-11)28-24(32)30-21-20-14-10-12(2-5-17(14)34-22(20)21)33-18-7-8-27-23-13(18)3-6-19(31)29-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,27,29,31)(H2,28,30,32)/t20-,21-,22-/m0/s1
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n/an/a 590n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM189798
PNG
(US9670203, Compound 1.51)
Show SMILES O=C(N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12)NC1CCCC1
Show InChI InChI=1S/C23H24N4O4/c28-18-8-6-14-17(9-10-24-22(14)26-18)30-13-5-7-16-15(11-13)19-20(21(19)31-16)27-23(29)25-12-3-1-2-4-12/h5,7,9-12,19-21H,1-4,6,8H2,(H,24,26,28)(H2,25,27,29)/t19-,20-,21-/m0/s1
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n/an/a 590n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186830
PNG
(US9670203, Compound 1.22 | US9670203, Compound 1.5...)
Show SMILES Fc1cccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1
Show InChI InChI=1S/C24H19FN4O4/c25-12-2-1-3-13(10-12)27-24(31)29-21-20-16-11-14(4-6-17(16)33-22(20)21)32-18-8-9-26-23-15(18)5-7-19(30)28-23/h1-4,6,8-11,20-22H,5,7H2,(H,26,28,30)(H2,27,29,31)/t20-,21-,22-/m0/s1
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n/an/a 710n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM190914
PNG
(US9670203, Compound 1.78)
Show SMILES CCCCCCNC(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
Show InChI InChI=1S/C24H28N4O4/c1-2-3-4-5-11-26-24(30)28-21-20-16-13-14(6-8-17(16)32-22(20)21)31-18-10-12-25-23-15(18)7-9-19(29)27-23/h6,8,10,12-13,20-22H,2-5,7,9,11H2,1H3,(H,25,27,29)(H2,26,28,30)/t20-,21-,22-/m0/s1
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n/an/a 720n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM189402
PNG
(US9670203, Compound 1.48)
Show SMILES Fc1ccc(F)c(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1F
Show InChI InChI=1S/C24H17F3N4O4/c25-13-3-4-14(26)20(19(13)27)30-24(33)31-21-18-12-9-10(1-5-15(12)35-22(18)21)34-16-7-8-28-23-11(16)2-6-17(32)29-23/h1,3-5,7-9,18,21-22H,2,6H2,(H,28,29,32)(H2,30,31,33)/t18-,21-,22-/m0/s1
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n/an/a 740n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM186840
PNG
(US9670203, Compound 1.28)
Show SMILES Clc1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc1Cl
Show InChI InChI=1S/C24H18Cl2N4O4/c25-15-4-1-11(9-16(15)26)28-24(32)30-21-20-14-10-12(2-5-17(14)34-22(20)21)33-18-7-8-27-23-13(18)3-6-19(31)29-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,27,29,31)(H2,28,30,32)/t20-,21-,22-/m0/s1
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n/an/a 770n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM186810
PNG
(US9670203, Compound 1.2)
Show SMILES FC(F)(F)c1ccnc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1
Show InChI InChI=1S/C24H18F3N5O4/c25-24(26,27)11-5-7-28-17(9-11)30-23(34)32-20-19-14-10-12(1-3-15(14)36-21(19)20)35-16-6-8-29-22-13(16)2-4-18(33)31-22/h1,3,5-10,19-21H,2,4H2,(H,29,31,33)(H2,28,30,32,34)/t19-,20-,21-/m0/s1
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n/an/a 770n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM189836
PNG
(US9670203, Compound 1.58)
Show SMILES Fc1cccc(CNC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1
Show InChI InChI=1S/C25H21FN4O4/c26-14-3-1-2-13(10-14)12-28-25(32)30-22-21-17-11-15(4-6-18(17)34-23(21)22)33-19-8-9-27-24-16(19)5-7-20(31)29-24/h1-4,6,8-11,21-23H,5,7,12H2,(H,27,29,31)(H2,28,30,32)/t21-,22-,23-/m0/s1
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n/an/a 770n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM189302
PNG
(US9670203, Compound 1.46)
Show SMILES Fc1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c(F)c1F
Show InChI InChI=1S/C24H17F3N4O4/c25-13-3-4-14(20(27)19(13)26)29-24(33)31-21-18-12-9-10(1-5-15(12)35-22(18)21)34-16-7-8-28-23-11(16)2-6-17(32)30-23/h1,3-5,7-9,18,21-22H,2,6H2,(H,28,30,32)(H2,29,31,33)/t18-,21-,22-/m0/s1
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n/an/a 780n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM188335
PNG
(US9670203, Compound 1.41)
Show SMILES Fc1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc1
Show InChI InChI=1S/C24H19FN4O4/c25-12-1-3-13(4-2-12)27-24(31)29-21-20-16-11-14(5-7-17(16)33-22(20)21)32-18-9-10-26-23-15(18)6-8-19(30)28-23/h1-5,7,9-11,20-22H,6,8H2,(H,26,28,30)(H2,27,29,31)/t20-,21-,22-/m0/s1
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n/an/a 800n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM189794
PNG
(US9670203, Compound 1.50)
Show SMILES COc1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc1
Show InChI InChI=1S/C25H22N4O5/c1-32-14-4-2-13(3-5-14)27-25(31)29-22-21-17-12-15(6-8-18(17)34-23(21)22)33-19-10-11-26-24-16(19)7-9-20(30)28-24/h2-6,8,10-12,21-23H,7,9H2,1H3,(H,26,28,30)(H2,27,29,31)/t21-,22-,23-/m0/s1
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n/an/a 800n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM190853
PNG
(US9670203, Compound 1.70 1-(3-(2-aminopropan-2-yl)...)
Show SMILES CC(C)(N)c1cc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H26F3N5O4/c1-27(2,32)13-9-14(28(29,30)31)11-15(10-13)34-26(38)36-23-22-18-12-16(3-5-19(18)40-24(22)23)39-20-7-8-33-25-17(20)4-6-21(37)35-25/h3,5,7-12,22-24H,4,6,32H2,1-2H3,(H,33,35,37)(H2,34,36,38)/t22-,23-,24-/m0/s1
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n/an/a 810n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM189839
PNG
(US9670203, Compound 1.59)
Show SMILES Fc1ccc(CNC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc1
Show InChI InChI=1S/C25H21FN4O4/c26-14-3-1-13(2-4-14)12-28-25(32)30-22-21-17-11-15(5-7-18(17)34-23(21)22)33-19-9-10-27-24-16(19)6-8-20(31)29-24/h1-5,7,9-11,21-23H,6,8,12H2,(H,27,29,31)(H2,28,30,32)/t21-,22-,23-/m0/s1
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n/an/a 840n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM190870
PNG
(US9670203, Compound 1.73 1-(4-((4-ethylpiperazin-1...)
Show SMILES CCN1CCN(Cc2ccc(NC(=O)N[C@@H]3[C@H]4Oc5ccc(Oc6ccnc7NC(=O)CCc67)cc5[C@@H]34)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C32H33F3N6O4/c1-2-40-11-13-41(14-12-40)17-18-3-4-19(15-23(18)32(33,34)35)37-31(43)39-28-27-22-16-20(5-7-24(22)45-29(27)28)44-25-9-10-36-30-21(25)6-8-26(42)38-30/h3-5,7,9-10,15-16,27-29H,2,6,8,11-14,17H2,1H3,(H,36,38,42)(H2,37,39,43)/t27-,28-,29-/m0/s1
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n/an/a 840n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM188327
PNG
(US9670203, Compound 1.37)
Show SMILES Clc1ccnc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1
Show InChI InChI=1S/C23H18ClN5O4/c24-11-5-7-25-17(9-11)27-23(31)29-20-19-14-10-12(1-3-15(14)33-21(19)20)32-16-6-8-26-22-13(16)2-4-18(30)28-22/h1,3,5-10,19-21H,2,4H2,(H,26,28,30)(H2,25,27,29,31)/t19-,20-,21-/m0/s1
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n/an/a 850n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM188336
PNG
(US9670203, Compound 1.42)
Show SMILES Fc1cccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1F
Show InChI InChI=1S/C24H18F2N4O4/c25-14-2-1-3-15(20(14)26)28-24(32)30-21-19-13-10-11(4-6-16(13)34-22(19)21)33-17-8-9-27-23-12(17)5-7-18(31)29-23/h1-4,6,8-10,19,21-22H,5,7H2,(H,27,29,31)(H2,28,30,32)/t19-,21-,22-/m0/s1
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n/an/a 940n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM186820
PNG
(US9670203, Compound 1.12)
Show SMILES Fc1c(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cccc1C(F)(F)F
Show InChI InChI=1S/C25H18F4N4O4/c26-20-14(25(27,28)29)2-1-3-15(20)31-24(35)33-21-19-13-10-11(4-6-16(13)37-22(19)21)36-17-8-9-30-23-12(17)5-7-18(34)32-23/h1-4,6,8-10,19,21-22H,5,7H2,(H,30,32,34)(H2,31,33,35)/t19-,21-,22-/m0/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM189301
PNG
(US9670203, Compound 1.45)
Show SMILES Fc1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc1F
Show InChI InChI=1S/C24H18F2N4O4/c25-15-4-1-11(9-16(15)26)28-24(32)30-21-20-14-10-12(2-5-17(14)34-22(20)21)33-18-7-8-27-23-13(18)3-6-19(31)29-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,27,29,31)(H2,28,30,32)/t20-,21-,22-/m0/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186829
PNG
(US9670203, Compound 1.21)
Show SMILES Fc1ccccc1NC(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
Show InChI InChI=1S/C24H19FN4O4/c25-15-3-1-2-4-16(15)27-24(31)29-21-20-14-11-12(5-7-17(14)33-22(20)21)32-18-9-10-26-23-13(18)6-8-19(30)28-23/h1-5,7,9-11,20-22H,6,8H2,(H,26,28,30)(H2,27,29,31)/t20-,21-,22-/m0/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186815
PNG
(US9670203, Compound 1.7)
Show SMILES Cc1cc(Cl)ccc1NC(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
Show InChI InChI=1S/C25H21ClN4O4/c1-12-10-13(26)2-5-17(12)28-25(32)30-22-21-16-11-14(3-6-18(16)34-23(21)22)33-19-8-9-27-24-15(19)4-7-20(31)29-24/h2-3,5-6,8-11,21-23H,4,7H2,1H3,(H,27,29,31)(H2,28,30,32)/t21-,22-,23-/m0/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM187117
PNG
(US9670203, Compound 1.32)
Show SMILES Fc1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc1C(F)(F)F
Show InChI InChI=1S/C25H18F4N4O4/c26-16-4-1-11(9-15(16)25(27,28)29)31-24(35)33-21-20-14-10-12(2-5-17(14)37-22(20)21)36-18-7-8-30-23-13(18)3-6-19(34)32-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,30,32,34)(H2,31,33,35)/t20-,21-,22-/m0/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM189734
PNG
(US9670203, Compound 1.49)
Show SMILES Fc1cc(F)c(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc1F
Show InChI InChI=1S/C24H17F3N4O4/c25-13-8-15(27)16(9-14(13)26)29-24(33)31-21-20-12-7-10(1-3-17(12)35-22(20)21)34-18-5-6-28-23-11(18)2-4-19(32)30-23/h1,3,5-9,20-22H,2,4H2,(H,28,30,32)(H2,29,31,33)/t20-,21-,22-/m0/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM189294
PNG
(US9670203, Compound 1.43)
Show SMILES Fc1ccc(F)c(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1
Show InChI InChI=1S/C24H18F2N4O4/c25-11-1-4-15(26)16(9-11)28-24(32)30-21-20-14-10-12(2-5-17(14)34-22(20)21)33-18-7-8-27-23-13(18)3-6-19(31)29-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,27,29,31)(H2,28,30,32)/t20-,21-,22-/m0/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186830
PNG
(US9670203, Compound 1.22 | US9670203, Compound 1.5...)
Show SMILES Fc1cccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1
Show InChI InChI=1S/C24H19FN4O4/c25-12-2-1-3-13(10-12)27-24(31)29-21-20-16-11-14(4-6-17(16)33-22(20)21)32-18-8-9-26-23-15(18)5-7-19(30)28-23/h1-4,6,8-11,20-22H,5,7H2,(H,26,28,30)(H2,27,29,31)/t20-,21-,22-/m0/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM189299
PNG
(US9670203, Compound 1.44)
Show SMILES Fc1cccc(F)c1NC(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
Show InChI InChI=1S/C24H18F2N4O4/c25-14-2-1-3-15(26)20(14)29-24(32)30-21-19-13-10-11(4-6-16(13)34-22(19)21)33-17-8-9-27-23-12(17)5-7-18(31)28-23/h1-4,6,8-10,19,21-22H,5,7H2,(H,27,28,31)(H2,29,30,32)/t19-,21-,22-/m0/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM188326
PNG
(US9670203, Compound 1.36)
Show SMILES O=C(N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12)Nc1ccncn1
Show InChI InChI=1S/C22H18N6O4/c29-17-4-2-12-15(5-8-24-21(12)27-17)31-11-1-3-14-13(9-11)18-19(20(18)32-14)28-22(30)26-16-6-7-23-10-25-16/h1,3,5-10,18-20H,2,4H2,(H,24,27,29)(H2,23,25,26,28,30)/t18-,19-,20-/m0/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM186323
PNG
(US9670203, Compound 1.1 1-((1S,1aS,6bS)-5-((7-oxo-...)
Show SMILES FC(F)(F)c1cccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1
Show InChI InChI=1S/C25H19F3N4O4/c26-25(27,28)12-2-1-3-13(10-12)30-24(34)32-21-20-16-11-14(4-6-17(16)36-22(20)21)35-18-8-9-29-23-15(18)5-7-19(33)31-23/h1-4,6,8-11,20-22H,5,7H2,(H,29,31,33)(H2,30,32,34)/t20-,21-,22-/m0/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM189824
PNG
(US9670203, Compound 1.52)
Show SMILES O=C(N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12)NC1CCCCCC1
Show InChI InChI=1S/C25H28N4O4/c30-20-10-8-16-19(11-12-26-24(16)28-20)32-15-7-9-18-17(13-15)21-22(23(21)33-18)29-25(31)27-14-5-3-1-2-4-6-14/h7,9,11-14,21-23H,1-6,8,10H2,(H,26,28,30)(H2,27,29,31)/t21-,22-,23-/m0/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186832
PNG
(US9670203, Compound 1.24)
Show SMILES Cc1cc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)ccc1F
Show InChI InChI=1S/C25H21FN4O4/c1-12-10-13(2-5-17(12)26)28-25(32)30-22-21-16-11-14(3-6-18(16)34-23(21)22)33-19-8-9-27-24-15(19)4-7-20(31)29-24/h2-3,5-6,8-11,21-23H,4,7H2,1H3,(H,27,29,31)(H2,28,30,32)/t21-,22-,23-/m0/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186825
PNG
(US9670203, Compound 1.17)
Show SMILES COc1cc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc(OC)c1
Show InChI InChI=1S/C26H24N4O6/c1-33-15-9-13(10-16(11-15)34-2)28-26(32)30-23-22-18-12-14(3-5-19(18)36-24(22)23)35-20-7-8-27-25-17(20)4-6-21(31)29-25/h3,5,7-12,22-24H,4,6H2,1-2H3,(H,27,29,31)(H2,28,30,32)/t22-,23-,24-/m0/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM186323
PNG
(US9670203, Compound 1.1 1-((1S,1aS,6bS)-5-((7-oxo-...)
Show SMILES FC(F)(F)c1cccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1
Show InChI InChI=1S/C25H19F3N4O4/c26-25(27,28)12-2-1-3-13(10-12)30-24(34)32-21-20-16-11-14(4-6-17(16)36-22(20)21)35-18-8-9-29-23-15(18)5-7-19(33)31-23/h1-4,6,8-11,20-22H,5,7H2,(H,29,31,33)(H2,30,32,34)/t20-,21-,22-/m0/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM186817
PNG
(US9670203, Compound 1.9)
Show SMILES FC(F)(F)c1cc(Cl)ccc1NC(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
Show InChI InChI=1S/C25H18ClF3N4O4/c26-11-1-4-16(15(9-11)25(27,28)29)31-24(35)33-21-20-14-10-12(2-5-17(14)37-22(20)21)36-18-7-8-30-23-13(18)3-6-19(34)32-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,30,32,34)(H2,31,33,35)/t20-,21-,22-/m0/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM188334
PNG
(US9670203, Compound 1.40)
Show SMILES Fc1cc(F)c(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c(F)c1
Show InChI InChI=1S/C24H17F3N4O4/c25-10-7-14(26)20(15(27)8-10)30-24(33)31-21-19-13-9-11(1-3-16(13)35-22(19)21)34-17-5-6-28-23-12(17)2-4-18(32)29-23/h1,3,5-9,19,21-22H,2,4H2,(H,28,29,32)(H2,30,31,33)/t19-,21-,22-/m0/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186323
PNG
(US9670203, Compound 1.1 1-((1S,1aS,6bS)-5-((7-oxo-...)
Show SMILES FC(F)(F)c1cccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1
Show InChI InChI=1S/C25H19F3N4O4/c26-25(27,28)12-2-1-3-13(10-12)30-24(34)32-21-20-16-11-14(4-6-17(16)36-22(20)21)35-18-8-9-29-23-15(18)5-7-19(33)31-23/h1-4,6,8-11,20-22H,5,7H2,(H,29,31,33)(H2,30,32,34)/t20-,21-,22-/m0/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186831
PNG
(US9670203, Compound 1.23)
Show SMILES Fc1cc(F)cc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1
Show InChI InChI=1S/C24H18F2N4O4/c25-11-7-12(26)9-13(8-11)28-24(32)30-21-20-16-10-14(1-3-17(16)34-22(20)21)33-18-5-6-27-23-15(18)2-4-19(31)29-23/h1,3,5-10,20-22H,2,4H2,(H,27,29,31)(H2,28,30,32)/t20-,21-,22-/m0/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM186819
PNG
(US9670203, Compound 1.11)
Show SMILES Fc1cc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc(c1)C(F)(F)F
Show InChI InChI=1S/C25H18F4N4O4/c26-12-7-11(25(27,28)29)8-13(9-12)31-24(35)33-21-20-16-10-14(1-3-17(16)37-22(20)21)36-18-5-6-30-23-15(18)2-4-19(34)32-23/h1,3,5-10,20-22H,2,4H2,(H,30,32,34)(H2,31,33,35)/t20-,21-,22-/m0/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186812
PNG
(US9670203, Compound 1.4)
Show SMILES COc1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c(Cl)c1
Show InChI InChI=1S/C25H21ClN4O5/c1-33-12-2-5-17(16(26)11-12)28-25(32)30-22-21-15-10-13(3-6-18(15)35-23(21)22)34-19-8-9-27-24-14(19)4-7-20(31)29-24/h2-3,5-6,8-11,21-23H,4,7H2,1H3,(H,27,29,31)(H2,28,30,32)/t21-,22-,23-/m0/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186821
PNG
(US9670203, Compound 1.13)
Show SMILES [O-][N+](=O)c1cccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1
Show InChI InChI=1S/C24H19N5O6/c30-19-7-5-15-18(8-9-25-23(15)27-19)34-14-4-6-17-16(11-14)20-21(22(20)35-17)28-24(31)26-12-2-1-3-13(10-12)29(32)33/h1-4,6,8-11,20-22H,5,7H2,(H,25,27,30)(H2,26,28,31)/t20-,21-,22-/m0/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM190865
PNG
(US9670203, Compound 1.72)
Show SMILES FC(F)(F)c1ccnc(NC(=O)N[C@H]2[C@@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@H]23)c1
Show InChI InChI=1S/C24H18F3N5O4/c25-24(26,27)11-5-7-28-17(9-11)30-23(34)32-20-19-14-10-12(1-3-15(14)36-21(19)20)35-16-6-8-29-22-13(16)2-4-18(33)31-22/h1,3,5-10,19-21H,2,4H2,(H,29,31,33)(H2,28,30,32,34)/t19-,20-,21-/m1/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186814
PNG
(US9670203, Compound 1.6)
Show SMILES COc1cccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1Cl
Show InChI InChI=1S/C25H21ClN4O5/c1-33-18-4-2-3-15(21(18)26)28-25(32)30-22-20-14-11-12(5-7-16(14)35-23(20)22)34-17-9-10-27-24-13(17)6-8-19(31)29-24/h2-5,7,9-11,20,22-23H,6,8H2,1H3,(H,27,29,31)(H2,28,30,32)/t20-,22-,23-/m0/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186822
PNG
(US9670203, Compound 1.14)
Show SMILES O=C(N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12)Nc1cccc(c1)C#C
Show InChI InChI=1S/C26H20N4O4/c1-2-14-4-3-5-15(12-14)28-26(32)30-23-22-18-13-16(6-8-19(18)34-24(22)23)33-20-10-11-27-25-17(20)7-9-21(31)29-25/h1,3-6,8,10-13,22-24H,7,9H2,(H,27,29,31)(H2,28,30,32)/t22-,23-,24-/m0/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM189826
PNG
(US9670203, Compound 1.54)
Show SMILES FC(F)(F)c1cccc(CNC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1
Show InChI InChI=1S/C26H21F3N4O4/c27-26(28,29)14-3-1-2-13(10-14)12-31-25(35)33-22-21-17-11-15(4-6-18(17)37-23(21)22)36-19-8-9-30-24-16(19)5-7-20(34)32-24/h1-4,6,8-11,21-23H,5,7,12H2,(H,30,32,34)(H2,31,33,35)/t21-,22-,23-/m0/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186813
PNG
(US9670203, Compound 1.5)
Show SMILES COc1ccc(Cl)c(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1
Show InChI InChI=1S/C25H21ClN4O5/c1-33-12-2-5-16(26)17(11-12)28-25(32)30-22-21-15-10-13(3-6-18(15)35-23(21)22)34-19-8-9-27-24-14(19)4-7-20(31)29-24/h2-3,5-6,8-11,21-23H,4,7H2,1H3,(H,27,29,31)(H2,28,30,32)/t21-,22-,23-/m0/s1
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n/an/a 2.20E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM190878
PNG
(US9670203, Compound 1.75 1-(2-methoxypyridin-4-yl)...)
Show SMILES COc1cc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)ccn1
Show InChI InChI=1S/C24H21N5O5/c1-32-19-10-12(6-8-25-19)27-24(31)29-21-20-15-11-13(2-4-16(15)34-22(20)21)33-17-7-9-26-23-14(17)3-5-18(30)28-23/h2,4,6-11,20-22H,3,5H2,1H3,(H,26,28,30)(H2,25,27,29,31)/t20-,21-,22-/m0/s1
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n/an/a 2.20E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM191230
PNG
(US9670203, Compound 2.5)
Show SMILES Fc1cc(F)c(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)NCc56)cc4[C@@H]23)cc1F
Show InChI InChI=1S/C23H16F3N5O4/c24-12-6-14(26)15(7-13(12)25)29-23(33)30-19-18-10-5-9(1-2-16(10)35-20(18)19)34-17-3-4-27-21-11(17)8-28-22(32)31-21/h1-7,18-20H,8H2,(H2,29,30,33)(H2,27,28,31,32)/t18-,19-,20-/m0/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM186833
PNG
(US9670203, Compound 1.25)
Show SMILES FC(F)(F)c1cc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)ccc1Cl
Show InChI InChI=1S/C25H18ClF3N4O4/c26-16-4-1-11(9-15(16)25(27,28)29)31-24(35)33-21-20-14-10-12(2-5-17(14)37-22(20)21)36-18-7-8-30-23-13(18)3-6-19(34)32-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,30,32,34)(H2,31,33,35)/t20-,21-,22-/m0/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186823
PNG
(US9670203, Compound 1.15)
Show SMILES COc1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc1OC
Show InChI InChI=1S/C26H24N4O6/c1-33-19-6-3-13(11-20(19)34-2)28-26(32)30-23-22-16-12-14(4-7-17(16)36-24(22)23)35-18-9-10-27-25-15(18)5-8-21(31)29-25/h3-4,6-7,9-12,22-24H,5,8H2,1-2H3,(H,27,29,31)(H2,28,30,32)/t22-,23-,24-/m0/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM189930
PNG
(US9670203, Compound 1.66)
Show SMILES O=C(N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12)NC1CCCCC1
Show InChI InChI=1S/C24H26N4O4/c29-19-9-7-15-18(10-11-25-23(15)27-19)31-14-6-8-17-16(12-14)20-21(22(20)32-17)28-24(30)26-13-4-2-1-3-5-13/h6,8,10-13,20-22H,1-5,7,9H2,(H,25,27,29)(H2,26,28,30)/t20-,21-,22-/m0/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM190952
PNG
(US9670203, Compound 1.82)
Show SMILES O=C(N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12)N[C@@H]1CCc2ccccc12
Show InChI InChI=1S/C27H24N4O4/c32-22-10-7-17-21(11-12-28-26(17)30-22)34-15-6-9-20-18(13-15)23-24(25(23)35-20)31-27(33)29-19-8-5-14-3-1-2-4-16(14)19/h1-4,6,9,11-13,19,23-25H,5,7-8,10H2,(H,28,30,32)(H2,29,31,33)/t19-,23+,24+,25+/m1/s1
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n/an/a 2.40E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM191048
PNG
(US9670203, Compound 2.3 1-((1S,1aS,6bS)-5-((2-oxo-...)
Show SMILES Fc1cc(F)c(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)OCc56)cc4[C@@H]23)cc1F
Show InChI InChI=1S/C23H15F3N4O5/c24-12-6-14(26)15(7-13(12)25)28-22(31)29-19-18-10-5-9(1-2-16(10)35-20(18)19)34-17-3-4-27-21-11(17)8-33-23(32)30-21/h1-7,18-20H,8H2,(H,27,30,32)(H2,28,29,31)/t18-,19-,20-/m0/s1
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n/an/a 2.60E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186824
PNG
(US9670203, Compound 1.16)
Show SMILES O=C(N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12)Nc1ccc2CCCc2c1
Show InChI InChI=1S/C27H24N4O4/c32-22-9-7-18-21(10-11-28-26(18)30-22)34-17-6-8-20-19(13-17)23-24(25(23)35-20)31-27(33)29-16-5-4-14-2-1-3-15(14)12-16/h4-6,8,10-13,23-25H,1-3,7,9H2,(H,28,30,32)(H2,29,31,33)/t23-,24-,25-/m0/s1
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n/an/a 2.60E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM188333
PNG
(US9670203, Compound 1.39)
Show SMILES Cc1ccncc1NC(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
Show InChI InChI=1S/C24H21N5O4/c1-12-6-8-25-11-16(12)27-24(31)29-21-20-15-10-13(2-4-17(15)33-22(20)21)32-18-7-9-26-23-14(18)3-5-19(30)28-23/h2,4,6-11,20-22H,3,5H2,1H3,(H,26,28,30)(H2,27,29,31)/t20-,21-,22-/m0/s1
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n/an/a 2.60E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM190917
PNG
(US9670203, Compound 1.81)
Show SMILES O=C(N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12)N[C@H]1CCc2ccccc12
Show InChI InChI=1S/C27H24N4O4/c32-22-10-7-17-21(11-12-28-26(17)30-22)34-15-6-9-20-18(13-15)23-24(25(23)35-20)31-27(33)29-19-8-5-14-3-1-2-4-16(14)19/h1-4,6,9,11-13,19,23-25H,5,7-8,10H2,(H,28,30,32)(H2,29,31,33)/t19-,23-,24-,25-/m0/s1
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n/an/a 2.70E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM186828
PNG
(US9670203, Compound 1.20)
Show SMILES Fc1cc(ccc1NC(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12)C(F)(F)F
Show InChI InChI=1S/C25H18F4N4O4/c26-15-9-11(25(27,28)29)1-4-16(15)31-24(35)33-21-20-14-10-12(2-5-17(14)37-22(20)21)36-18-7-8-30-23-13(18)3-6-19(34)32-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,30,32,34)(H2,31,33,35)/t20-,21-,22-/m0/s1
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n/an/a 2.70E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM189825
PNG
(US9670203, Compound 1.53)
Show SMILES Fc1cc(F)c(F)c(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1
Show InChI InChI=1S/C24H17F3N4O4/c25-10-7-14(26)20(27)15(8-10)29-24(33)31-21-19-13-9-11(1-3-16(13)35-22(19)21)34-17-5-6-28-23-12(17)2-4-18(32)30-23/h1,3,5-9,19,21-22H,2,4H2,(H,28,30,32)(H2,29,31,33)/t19-,21-,22-/m0/s1
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n/an/a 2.90E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM190976
PNG
(US9670203, Compound 1.83)
Show SMILES CC(C)(C)CNC(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
Show InChI InChI=1S/C23H26N4O4/c1-23(2,3)11-25-22(29)27-19-18-14-10-12(4-6-15(14)31-20(18)19)30-16-8-9-24-21-13(16)5-7-17(28)26-21/h4,6,8-10,18-20H,5,7,11H2,1-3H3,(H,24,26,28)(H2,25,27,29)/t18-,19-,20-/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM190858
PNG
(US9670203, Compound 1.71 1-((1R,1aR,6bR)-5-((7-oxo...)
Show SMILES FC(F)(F)c1cccc(NC(=O)N[C@H]2[C@@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@H]23)c1
Show InChI InChI=1S/C25H19F3N4O4/c26-25(27,28)12-2-1-3-13(10-12)30-24(34)32-21-20-16-11-14(4-6-17(16)36-22(20)21)35-18-8-9-29-23-15(18)5-7-19(33)31-23/h1-4,6,8-11,20-22H,5,7H2,(H,29,31,33)(H2,30,32,34)/t20-,21-,22-/m1/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM187106
PNG
(US9670203, Compound 1.30)
Show SMILES FC(F)(F)c1ccccc1NC(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
Show InChI InChI=1S/C25H19F3N4O4/c26-25(27,28)15-3-1-2-4-16(15)30-24(34)32-21-20-14-11-12(5-7-17(14)36-22(20)21)35-18-9-10-29-23-13(18)6-8-19(33)31-23/h1-5,7,9-11,20-22H,6,8H2,(H,29,31,33)(H2,30,32,34)/t20-,21-,22-/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM191345
PNG
(US9670203, Compound 2.8)
Show SMILES CNC(=O)c1cc(Oc2ccc3O[C@@H]4[C@@H](NC(=O)Nc5cc(F)c(F)cc5F)[C@@H]4c3c2)ccn1
Show InChI InChI=1S/C23H17F3N4O4/c1-27-22(31)17-7-11(4-5-28-17)33-10-2-3-18-12(6-10)19-20(21(19)34-18)30-23(32)29-16-9-14(25)13(24)8-15(16)26/h2-9,19-21H,1H3,(H,27,31)(H2,29,30,32)/t19-,20-,21-/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM190915
PNG
(US9670203, Compound 1.79)
Show SMILES O=C(N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12)N[C@H]1CCCc2ccccc12
Show InChI InChI=1S/C28H26N4O4/c33-23-11-9-18-22(12-13-29-27(18)31-23)35-16-8-10-21-19(14-16)24-25(26(24)36-21)32-28(34)30-20-7-3-5-15-4-1-2-6-17(15)20/h1-2,4,6,8,10,12-14,20,24-26H,3,5,7,9,11H2,(H,29,31,33)(H2,30,32,34)/t20-,24-,25-,26-/m0/s1
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n/an/a 3.20E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM190901
PNG
(US9670203, Compound 1.76)
Show SMILES Fc1ccc(CNC(=O)NC2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c(c1)C(F)(F)F
Show InChI InChI=1S/C26H20F4N4O4/c27-13-2-1-12(17(9-13)26(28,29)30)11-32-25(36)34-22-21-16-10-14(3-5-18(16)38-23(21)22)37-19-7-8-31-24-15(19)4-6-20(35)33-24/h1-3,5,7-10,21-23H,4,6,11H2,(H,31,33,35)(H2,32,34,36)/t21-,22?,23-/m0/s1
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n/an/a 3.40E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186810
PNG
(US9670203, Compound 1.2)
Show SMILES FC(F)(F)c1ccnc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1
Show InChI InChI=1S/C24H18F3N5O4/c25-24(26,27)11-5-7-28-17(9-11)30-23(34)32-20-19-14-10-12(1-3-15(14)36-21(19)20)35-16-6-8-29-22-13(16)2-4-18(33)31-22/h1,3,5-10,19-21H,2,4H2,(H,29,31,33)(H2,28,30,32,34)/t19-,20-,21-/m0/s1
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n/an/a 4.00E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM190916
PNG
(US9670203, Compound 1.80)
Show SMILES O=C(N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12)N[C@@H]1CCCc2ccccc12
Show InChI InChI=1S/C28H26N4O4/c33-23-11-9-18-22(12-13-29-27(18)31-23)35-16-8-10-21-19(14-16)24-25(26(24)36-21)32-28(34)30-20-7-3-5-15-4-1-2-6-17(15)20/h1-2,4,6,8,10,12-14,20,24-26H,3,5,7,9,11H2,(H,29,31,33)(H2,30,32,34)/t20-,24+,25+,26+/m1/s1
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n/an/a 4.00E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM188331
PNG
(US9670203, Compound 1.38)
Show SMILES FC(F)(F)c1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)nc1
Show InChI InChI=1S/C24H18F3N5O4/c25-24(26,27)11-1-5-17(29-10-11)30-23(34)32-20-19-14-9-12(2-4-15(14)36-21(19)20)35-16-7-8-28-22-13(16)3-6-18(33)31-22/h1-2,4-5,7-10,19-21H,3,6H2,(H,28,31,33)(H2,29,30,32,34)/t19-,20-,21-/m0/s1
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n/an/a 4.00E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM189357
PNG
(US9670203, Compound 1.47)
Show SMILES Fc1cc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc(F)c1F
Show InChI InChI=1S/C17H23NO2/c1-13-17(2,3)14-9-6-7-10-15(14)18(13)12-8-4-5-11-16(19)20/h6-7,9-10H,1,4-5,8,11-12H2,2-3H3,(H,19,20)
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n/an/a 4.10E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM190805
PNG
(US9670203, Compound 1.67)
Show SMILES O=C(N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12)NC1CCOCC1
Show InChI InChI=1S/C23H24N4O5/c28-18-4-2-14-17(5-8-24-22(14)26-18)31-13-1-3-16-15(11-13)19-20(21(19)32-16)27-23(29)25-12-6-9-30-10-7-12/h1,3,5,8,11-12,19-21H,2,4,6-7,9-10H2,(H,24,26,28)(H2,25,27,29)/t19-,20-,21-/m0/s1
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n/an/a 4.20E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM190902
PNG
(US9670203, Compound 1.77)
Show SMILES CC(C)(C)NC(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
Show InChI InChI=1S/C22H24N4O4/c1-22(2,3)26-21(28)25-18-17-13-10-11(4-6-14(13)30-19(17)18)29-15-8-9-23-20-12(15)5-7-16(27)24-20/h4,6,8-10,17-19H,5,7H2,1-3H3,(H,23,24,27)(H2,25,26,28)/t17-,18-,19-/m0/s1
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n/an/a 4.50E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186820
PNG
(US9670203, Compound 1.12)
Show SMILES Fc1c(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cccc1C(F)(F)F
Show InChI InChI=1S/C25H18F4N4O4/c26-20-14(25(27,28)29)2-1-3-15(20)31-24(35)33-21-19-13-10-11(4-6-16(13)37-22(19)21)36-17-8-9-30-23-12(17)5-7-18(34)32-23/h1-4,6,8-10,19,21-22H,5,7H2,(H,30,32,34)(H2,31,33,35)/t19-,21-,22-/m0/s1
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n/an/a 4.70E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186827
PNG
(US9670203, Compound 1.19)
Show SMILES Cc1cccc(Cl)c1NC(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
Show InChI InChI=1S/C25H21ClN4O4/c1-12-3-2-4-16(26)21(12)29-25(32)30-22-20-15-11-13(5-7-17(15)34-23(20)22)33-18-9-10-27-24-14(18)6-8-19(31)28-24/h2-5,7,9-11,20,22-23H,6,8H2,1H3,(H,27,28,31)(H2,29,30,32)/t20-,22-,23-/m0/s1
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n/an/a 5.10E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186840
PNG
(US9670203, Compound 1.28)
Show SMILES Clc1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc1Cl
Show InChI InChI=1S/C24H18Cl2N4O4/c25-15-4-1-11(9-16(15)26)28-24(32)30-21-20-14-10-12(2-5-17(14)34-22(20)21)33-18-7-8-27-23-13(18)3-6-19(31)29-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,27,29,31)(H2,28,30,32)/t20-,21-,22-/m0/s1
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n/an/a 5.50E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186819
PNG
(US9670203, Compound 1.11)
Show SMILES Fc1cc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc(c1)C(F)(F)F
Show InChI InChI=1S/C25H18F4N4O4/c26-12-7-11(25(27,28)29)8-13(9-12)31-24(35)33-21-20-16-10-14(1-3-17(16)37-22(20)21)36-18-5-6-30-23-15(18)2-4-19(34)32-23/h1,3,5-10,20-22H,2,4H2,(H,30,32,34)(H2,31,33,35)/t20-,21-,22-/m0/s1
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n/an/a 5.50E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM189848
PNG
(US9670203, Compound 1.62)
Show SMILES FC(F)(F)Oc1ccccc1NC(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
Show InChI InChI=1S/C25H19F3N4O5/c26-25(27,28)37-18-4-2-1-3-15(18)30-24(34)32-21-20-14-11-12(5-7-16(14)36-22(20)21)35-17-9-10-29-23-13(17)6-8-19(33)31-23/h1-5,7,9-11,20-22H,6,8H2,(H,29,31,33)(H2,30,32,34)/t20-,21-,22-/m0/s1
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n/an/a 6.30E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186818
PNG
(US9670203, Compound 1.10)
Show SMILES Clc1cc(Br)ccc1NC(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
Show InChI InChI=1S/C24H18BrClN4O4/c25-11-1-4-16(15(26)9-11)28-24(32)30-21-20-14-10-12(2-5-17(14)34-22(20)21)33-18-7-8-27-23-13(18)3-6-19(31)29-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,27,29,31)(H2,28,30,32)/t20-,21-,22-/m0/s1
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n/an/a 6.30E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186841
PNG
(US9670203, Compound 1.29)
Show SMILES FC(F)(F)c1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc1
Show InChI InChI=1S/C25H19F3N4O4/c26-25(27,28)12-1-3-13(4-2-12)30-24(34)32-21-20-16-11-14(5-7-17(16)36-22(20)21)35-18-9-10-29-23-15(18)6-8-19(33)31-23/h1-5,7,9-11,20-22H,6,8H2,(H,29,31,33)(H2,30,32,34)/t20-,21-,22-/m0/s1
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n/an/a 6.90E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM189847
PNG
(US9670203, Compound 1.61)
Show SMILES FC(F)(F)Oc1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc1
Show InChI InChI=1S/C25H19F3N4O5/c26-25(27,28)37-13-3-1-12(2-4-13)30-24(34)32-21-20-16-11-14(5-7-17(16)36-22(20)21)35-18-9-10-29-23-15(18)6-8-19(33)31-23/h1-5,7,9-11,20-22H,6,8H2,(H,29,31,33)(H2,30,32,34)/t20-,21-,22-/m0/s1
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n/an/a 7.40E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM190853
PNG
(US9670203, Compound 1.70 1-(3-(2-aminopropan-2-yl)...)
Show SMILES CC(C)(N)c1cc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H26F3N5O4/c1-27(2,32)13-9-14(28(29,30)31)11-15(10-13)34-26(38)36-23-22-18-12-16(3-5-19(18)40-24(22)23)39-20-7-8-33-25-17(20)4-6-21(37)35-25/h3,5,7-12,22-24H,4,6,32H2,1-2H3,(H,33,35,37)(H2,34,36,38)/t22-,23-,24-/m0/s1
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n/an/a 7.40E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM187117
PNG
(US9670203, Compound 1.32)
Show SMILES Fc1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc1C(F)(F)F
Show InChI InChI=1S/C25H18F4N4O4/c26-16-4-1-11(9-15(16)25(27,28)29)31-24(35)33-21-20-14-10-12(2-5-17(14)37-22(20)21)36-18-7-8-30-23-13(18)3-6-19(34)32-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,30,32,34)(H2,31,33,35)/t20-,21-,22-/m0/s1
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n/an/a 7.70E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186323
PNG
(US9670203, Compound 1.1 1-((1S,1aS,6bS)-5-((7-oxo-...)
Show SMILES FC(F)(F)c1cccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1
Show InChI InChI=1S/C25H19F3N4O4/c26-25(27,28)12-2-1-3-13(10-12)30-24(34)32-21-20-16-11-14(4-6-17(16)36-22(20)21)35-18-8-9-29-23-15(18)5-7-19(33)31-23/h1-4,6,8-11,20-22H,5,7H2,(H,29,31,33)(H2,30,32,34)/t20-,21-,22-/m0/s1
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n/an/a 8.30E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM189841
PNG
(US9670203, Compound 1.60)
Show SMILES FC(F)(F)Oc1cccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1
Show InChI InChI=1S/C25H19F3N4O5/c26-25(27,28)37-14-3-1-2-12(10-14)30-24(34)32-21-20-16-11-13(4-6-17(16)36-22(20)21)35-18-8-9-29-23-15(18)5-7-19(33)31-23/h1-4,6,8-11,20-22H,5,7H2,(H,29,31,33)(H2,30,32,34)/t20-,21-,22-/m0/s1
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n/an/a 8.60E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186816
PNG
(US9670203, Compound 1.8)
Show SMILES Clc1ccc(Br)cc1NC(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
Show InChI InChI=1S/C24H18BrClN4O4/c25-11-1-4-15(26)16(9-11)28-24(32)30-21-20-14-10-12(2-5-17(14)34-22(20)21)33-18-7-8-27-23-13(18)3-6-19(31)29-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,27,29,31)(H2,28,30,32)/t20-,21-,22-/m0/s1
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n/an/a 8.70E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186817
PNG
(US9670203, Compound 1.9)
Show SMILES FC(F)(F)c1cc(Cl)ccc1NC(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
Show InChI InChI=1S/C25H18ClF3N4O4/c26-11-1-4-16(15(9-11)25(27,28)29)31-24(35)33-21-20-14-10-12(2-5-17(14)37-22(20)21)36-18-7-8-30-23-13(18)3-6-19(34)32-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,30,32,34)(H2,31,33,35)/t20-,21-,22-/m0/s1
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n/an/a 9.50E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM187118
PNG
(US9670203, Compound 1.33)
Show SMILES Fc1ccc(cc1NC(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12)C(F)(F)F
Show InChI InChI=1S/C25H18F4N4O4/c26-15-4-1-11(25(27,28)29)9-16(15)31-24(35)33-21-20-14-10-12(2-5-17(14)37-22(20)21)36-18-7-8-30-23-13(18)3-6-19(34)32-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,30,32,34)(H2,31,33,35)/t20-,21-,22-/m0/s1
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n/an/a 9.50E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM191353
PNG
(US9670203, Compound 2.12 1-((1S,1aS,6bS)-5-((9H-pu...)
Show SMILES C[Si](C)(C)CCOCn1cnc2c(Oc3ccc4O[C@@H]5[C@@H](NC(=O)Nc6ccc(F)c(c6)C(F)(F)F)[C@@H]5c4c3)ncnc12
Show InChI InChI=1S/C28H28F4N6O4Si/c1-43(2,3)9-8-40-14-38-13-35-23-25(38)33-12-34-26(23)41-16-5-7-20-17(11-16)21-22(24(21)42-20)37-27(39)36-15-4-6-19(29)18(10-15)28(30,31)32/h4-7,10-13,21-22,24H,8-9,14H2,1-3H3,(H2,36,37,39)/t21-,22-,24-/m0/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM191049
PNG
(US9670203, Compound 2.4 1-(4-fluoro-3-(trifluorome...)
Show SMILES Fc1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)NCc56)cc4[C@@H]23)cc1C(F)(F)F
Show InChI InChI=1S/C24H17F4N5O4/c25-15-3-1-10(7-14(15)24(26,27)28)31-23(35)32-19-18-12-8-11(2-4-16(12)37-20(18)19)36-17-5-6-29-21-13(17)9-30-22(34)33-21/h1-8,18-20H,9H2,(H2,31,32,35)(H2,29,30,33,34)/t18-,19-,20-/m0/s1
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n/an/a 1.10E+4n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186839
PNG
(US9670203, Compound 1.27)
Show SMILES COc1cc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c(Cl)cc1Cl
Show InChI InChI=1S/C25H20Cl2N4O5/c1-34-19-10-16(14(26)9-15(19)27)29-25(33)31-22-21-13-8-11(2-4-17(13)36-23(21)22)35-18-6-7-28-24-12(18)3-5-20(32)30-24/h2,4,6-10,21-23H,3,5H2,1H3,(H,28,30,32)(H2,29,31,33)/t21-,22-,23-/m0/s1
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n/an/a 1.10E+4n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM190977
PNG
(US9670203, Compound 1.84)
Show SMILES CCCCCCCCNC(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
Show InChI InChI=1S/C26H32N4O4/c1-2-3-4-5-6-7-13-28-26(32)30-23-22-18-15-16(8-10-19(18)34-24(22)23)33-20-12-14-27-25-17(20)9-11-21(31)29-25/h8,10,12,14-15,22-24H,2-7,9,11,13H2,1H3,(H,27,29,31)(H2,28,30,32)/t22-,23-,24-/m0/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM187119
PNG
(US9670203, Compound 1.34)
Show SMILES COc1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc1C(F)(F)F
Show InChI InChI=1S/C26H21F3N4O5/c1-36-19-5-2-12(10-16(19)26(27,28)29)31-25(35)33-22-21-15-11-13(3-6-17(15)38-23(21)22)37-18-8-9-30-24-14(18)4-7-20(34)32-24/h2-3,5-6,8-11,21-23H,4,7H2,1H3,(H,30,32,34)(H2,31,33,35)/t21-,22-,23-/m0/s1
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n/an/a 1.26E+4n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM191345
PNG
(US9670203, Compound 2.8)
Show SMILES CNC(=O)c1cc(Oc2ccc3O[C@@H]4[C@@H](NC(=O)Nc5cc(F)c(F)cc5F)[C@@H]4c3c2)ccn1
Show InChI InChI=1S/C23H17F3N4O4/c1-27-22(31)17-7-11(4-5-28-17)33-10-2-3-18-12(6-10)19-20(21(19)34-18)30-23(32)29-16-9-14(25)13(24)8-15(16)26/h2-9,19-21H,1H3,(H,27,31)(H2,29,30,32)/t19-,20-,21-/m0/s1
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n/an/a 1.30E+4n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186828
PNG
(US9670203, Compound 1.20)
Show SMILES Fc1cc(ccc1NC(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12)C(F)(F)F
Show InChI InChI=1S/C25H18F4N4O4/c26-15-9-11(25(27,28)29)1-4-16(15)31-24(35)33-21-20-14-10-12(2-5-17(14)37-22(20)21)36-18-7-8-30-23-13(18)3-6-19(34)32-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,30,32,34)(H2,31,33,35)/t20-,21-,22-/m0/s1
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n/an/a 1.30E+4n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM190870
PNG
(US9670203, Compound 1.73 1-(4-((4-ethylpiperazin-1...)
Show SMILES CCN1CCN(Cc2ccc(NC(=O)N[C@@H]3[C@H]4Oc5ccc(Oc6ccnc7NC(=O)CCc67)cc5[C@@H]34)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C32H33F3N6O4/c1-2-40-11-13-41(14-12-40)17-18-3-4-19(15-23(18)32(33,34)35)37-31(43)39-28-27-22-16-20(5-7-24(22)45-29(27)28)44-25-9-10-36-30-21(25)6-8-26(42)38-30/h3-5,7,9-10,15-16,27-29H,2,6,8,11-14,17H2,1H3,(H,36,38,42)(H2,37,39,43)/t27-,28-,29-/m0/s1
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n/an/a 1.30E+4n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186826
PNG
(US9670203, Compound 1.18)
Show SMILES CC(C)(C)c1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc1
Show InChI InChI=1S/C28H28N4O4/c1-28(2,3)15-4-6-16(7-5-15)30-27(34)32-24-23-19-14-17(8-10-20(19)36-25(23)24)35-21-12-13-29-26-18(21)9-11-22(33)31-26/h4-8,10,12-14,23-25H,9,11H2,1-3H3,(H,29,31,33)(H2,30,32,34)/t23-,24-,25-/m0/s1
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n/an/a 1.60E+4n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186323
PNG
(US9670203, Compound 1.1 1-((1S,1aS,6bS)-5-((7-oxo-...)
Show SMILES FC(F)(F)c1cccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1
Show InChI InChI=1S/C25H19F3N4O4/c26-25(27,28)12-2-1-3-13(10-12)30-24(34)32-21-20-16-11-14(4-6-17(16)36-22(20)21)35-18-8-9-29-23-15(18)5-7-19(33)31-23/h1-4,6,8-11,20-22H,5,7H2,(H,29,31,33)(H2,30,32,34)/t20-,21-,22-/m0/s1
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n/an/a 1.70E+4n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM191362
PNG
(US9670203, Compound 2.15)
Show SMILES Nc1cc(Oc2ccc3O[C@@H]4[C@@H](NC(=O)Nc5cc(F)c(F)cc5F)[C@@H]4c3c2)ccn1
Show InChI InChI=1S/C21H15F3N4O3/c22-12-7-14(24)15(8-13(12)23)27-21(29)28-19-18-11-5-9(1-2-16(11)31-20(18)19)30-10-3-4-26-17(25)6-10/h1-8,18-20H,(H2,25,26)(H2,27,28,29)/t18-,19-,20-/m0/s1
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n/an/a 1.80E+4n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM190806
PNG
(US9670203, Compound 1.68)
Show SMILES CN1CCC(CC1)NC(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
Show InChI InChI=1S/C24H27N5O4/c1-29-10-7-13(8-11-29)26-24(31)28-21-20-16-12-14(2-4-17(16)33-22(20)21)32-18-6-9-25-23-15(18)3-5-19(30)27-23/h2,4,6,9,12-13,20-22H,3,5,7-8,10-11H2,1H3,(H,25,27,30)(H2,26,28,31)/t20-,21-,22-/m0/s1
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n/an/a 2.00E+4n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM191354
PNG
(US9670203, Compound 2.13)
Show SMILES Fc1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ncnc6[nH]cnc56)cc4[C@@H]23)c(F)c1
Show InChI InChI=1S/C21H14F2N6O3/c22-9-1-3-13(12(23)5-9)28-21(30)29-16-15-11-6-10(2-4-14(11)32-18(15)16)31-20-17-19(25-7-24-17)26-8-27-20/h1-8,15-16,18H,(H2,28,29,30)(H,24,25,26,27)/t15-,16-,18-/m0/s1
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n/an/a 2.40E+4n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM191348
PNG
(US9670203, Compound 2.9 1-((1S,1aS,6bS)-5-((2-amin...)
Show SMILES Fc1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccncc5)cc4[C@@H]23)cc1C(F)(F)F
Show InChI InChI=1S/C22H15F4N3O3/c23-16-3-1-11(9-15(16)22(24,25)26)28-21(30)29-19-18-14-10-13(2-4-17(14)32-20(18)19)31-12-5-7-27-8-6-12/h1-10,18-20H,(H2,28,29,30)/t18-,19-,20-/m0/s1
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n/an/a 2.40E+4n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM191338
PNG
(US9670203, Compound 2.6 N-methyl-4-(((1S,1aS,6bS)-...)
Show SMILES CNC(=O)c1cc(Oc2ccc3O[C@@H]4[C@@H](NC(=O)Nc5cccc(c5)C(F)(F)F)[C@@H]4c3c2)ccn1
Show InChI InChI=1S/C24H19F3N4O4/c1-28-22(32)17-11-15(7-8-29-17)34-14-5-6-18-16(10-14)19-20(21(19)35-18)31-23(33)30-13-4-2-3-12(9-13)24(25,26)27/h2-11,19-21H,1H3,(H,28,32)(H2,30,31,33)/t19-,20-,21-/m0/s1
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n/an/a 2.60E+4n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM189851
PNG
(US9670203, Compound 1.64)
Show SMILES Fc1cc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)ccc1C(F)(F)F
Show InChI InChI=1S/C25H18F4N4O4/c26-16-9-11(1-4-15(16)25(27,28)29)31-24(35)33-21-20-14-10-12(2-5-17(14)37-22(20)21)36-18-7-8-30-23-13(18)3-6-19(34)32-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,30,32,34)(H2,31,33,35)/t20-,21-,22-/m0/s1
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n/an/a 2.70E+4n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186833
PNG
(US9670203, Compound 1.25)
Show SMILES FC(F)(F)c1cc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)ccc1Cl
Show InChI InChI=1S/C25H18ClF3N4O4/c26-16-4-1-11(9-15(16)25(27,28)29)31-24(35)33-21-20-14-10-12(2-5-17(14)37-22(20)21)36-18-7-8-30-23-13(18)3-6-19(34)32-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,30,32,34)(H2,31,33,35)/t20-,21-,22-/m0/s1
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n/an/a 2.70E+4n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM190830
PNG
(US9670203, Compound 1.69)
Show SMILES O=C(NC1CC1)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
Show InChI InChI=1S/C21H20N4O4/c26-16-6-4-12-15(7-8-22-20(12)24-16)28-11-3-5-14-13(9-11)17-18(19(17)29-14)25-21(27)23-10-1-2-10/h3,5,7-10,17-19H,1-2,4,6H2,(H,22,24,26)(H2,23,25,27)/t17-,18-,19-/m0/s1
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n/an/a 3.00E+4n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (human))
BDBM50396483
PNG
(PLX-4032 | RG 7204 | Ro 5185426 | US9388165, Refer...)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F
Show InChI InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28)
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n/an/a 3.10E+4n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM191343
PNG
(US9670203, Compound 2.7)
Show SMILES CNC(=O)c1cc(Oc2ccc3O[C@@H]4[C@@H](NC(=O)Nc5ccc(F)c(c5)C(F)(F)F)[C@@H]4c3c2)ccn1
Show InChI InChI=1S/C24H18F4N4O4/c1-29-22(33)17-10-13(6-7-30-17)35-12-3-5-18-14(9-12)19-20(21(19)36-18)32-23(34)31-11-2-4-16(25)15(8-11)24(26,27)28/h2-10,19-21H,1H3,(H,29,33)(H2,31,32,34)/t19-,20-,21-/m0/s1
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n/an/a 3.30E+4n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM50396483
PNG
(PLX-4032 | RG 7204 | Ro 5185426 | US9388165, Refer...)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F
Show InChI InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28)
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n/an/a 3.30E+4n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM191355
PNG
(US9670203, Compound 2.14 1-((1S,1aS,6bS)-5-((2-ami...)
Show SMILES Nc1cc(Oc2ccc3O[C@@H]4[C@@H](NC(=O)Nc5ccc(F)cc5F)[C@@H]4c3c2)ccn1
Show InChI InChI=1S/C21H16F2N4O3/c22-10-1-3-15(14(23)7-10)26-21(28)27-19-18-13-8-11(2-4-16(13)30-20(18)19)29-12-5-6-25-17(24)9-12/h1-9,18-20H,(H2,24,25)(H2,26,27,28)/t18-,19-,20-/m0/s1
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n/an/a 3.60E+4n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186811
PNG
(US9670203, Compound 1.3)
Show SMILES COc1ccc(CNC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc1
Show InChI InChI=1S/C26H24N4O5/c1-33-15-4-2-14(3-5-15)13-28-26(32)30-23-22-18-12-16(6-8-19(18)35-24(22)23)34-20-10-11-27-25-17(20)7-9-21(31)29-25/h2-6,8,10-12,22-24H,7,9,13H2,1H3,(H,27,29,31)(H2,28,30,32)/t22-,23-,24-/m0/s1
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n/an/a 4.00E+4n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM191349
PNG
(US9670203, Compound 2.10)
Show SMILES Fc1cc(F)c(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccncc5)cc4[C@@H]23)cc1F
Show InChI InChI=1S/C21H14F3N3O3/c22-13-8-15(24)16(9-14(13)23)26-21(28)27-19-18-12-7-11(1-2-17(12)30-20(18)19)29-10-3-5-25-6-4-10/h1-9,18-20H,(H2,26,27,28)/t18-,19-,20-/m0/s1
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n/an/a 5.00E+4n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM191350
PNG
(US9670203, Compound 2.11)
Show SMILES FC(F)(F)c1cccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccncc5)cc4[C@@H]23)c1
Show InChI InChI=1S/C22H16F3N3O3/c23-22(24,25)12-2-1-3-13(10-12)27-21(29)28-19-18-16-11-15(4-5-17(16)31-20(18)19)30-14-6-8-26-9-7-14/h1-11,18-20H,(H2,27,28,29)/t18-,19-,20-/m0/s1
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n/an/a 5.80E+4n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM191368
PNG
(US9670203, Compound 2.16)
Show SMILES CNC(=O)c1cc(Oc2ccc3O[C@@H]4[C@@H](NC(=O)Nc5ccc(Cl)c(c5)C(F)(F)F)[C@@H]4c3c2)ccn1
Show InChI InChI=1S/C24H18ClF3N4O4/c1-29-22(33)17-10-13(6-7-30-17)35-12-3-5-18-14(9-12)19-20(21(19)36-18)32-23(34)31-11-2-4-16(25)15(8-11)24(26,27)28/h2-10,19-21H,1H3,(H,29,33)(H2,31,32,34)/t19-,20-,21-/m0/s1
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n/an/a 8.80E+4n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM191047
PNG
(US9670203, Compound 2.2 was prepared according to ...)
Show SMILES Fc1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccncn5)cc4[C@@H]23)cc1F
Show InChI InChI=1S/C20H14F2N4O3/c21-13-3-1-10(7-14(13)22)25-20(27)26-18-17-12-8-11(2-4-15(12)29-19(17)18)28-16-5-6-23-9-24-16/h1-9,17-19H,(H2,25,26,27)/t17-,18-,19-/m0/s1
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n/an/a 1.11E+5n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM189852
PNG
(US9670203, Compound 1.65)
Show SMILES FC(F)(F)c1cc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc(c1)C(F)(F)F
Show InChI InChI=1S/C26H18F6N4O4/c27-25(28,29)11-7-12(26(30,31)32)9-13(8-11)34-24(38)36-21-20-16-10-14(1-3-17(16)40-22(20)21)39-18-5-6-33-23-15(18)2-4-19(37)35-23/h1,3,5-10,20-22H,2,4H2,(H,33,35,37)(H2,34,36,38)/t20-,21-,22-/m0/s1
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n/an/a 1.16E+5n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM190991
PNG
(US9670203, Compound 1.85)
Show SMILES CCCCCCCCCCNC(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
Show InChI InChI=1S/C28H36N4O4/c1-2-3-4-5-6-7-8-9-15-30-28(34)32-25-24-20-17-18(10-12-21(20)36-26(24)25)35-22-14-16-29-27-19(22)11-13-23(33)31-27/h10,12,14,16-17,24-26H,2-9,11,13,15H2,1H3,(H,29,31,33)(H2,30,32,34)/t24-,25-,26-/m0/s1
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n/an/a 1.29E+5n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM189828
PNG
(US9670203, Compound 1.56)
Show SMILES FC(F)(F)c1ccc(CNC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc1
Show InChI InChI=1S/C26H21F3N4O4/c27-26(28,29)14-3-1-13(2-4-14)12-31-25(35)33-22-21-17-11-15(5-7-18(17)37-23(21)22)36-19-9-10-30-24-16(19)6-8-20(34)32-24/h1-5,7,9-11,21-23H,6,8,12H2,(H,30,32,34)(H2,31,33,35)/t21-,22-,23-/m0/s1
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n/an/a 1.58E+5n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM190992
PNG
(US9670203, Compound 1.86 1-(4-(4-methylpiperazin-1...)
Show SMILES CN1CCN(CC1)c1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc1C(F)(F)F
Show InChI InChI=1S/C30H29F3N6O4/c1-38-10-12-39(13-11-38)21-5-2-16(14-20(21)30(31,32)33)35-29(41)37-26-25-19-15-17(3-6-22(19)43-27(25)26)42-23-8-9-34-28-18(23)4-7-24(40)36-28/h2-3,5-6,8-9,14-15,25-27H,4,7,10-13H2,1H3,(H,34,36,40)(H2,35,37,41)/t25-,26-,27-/m0/s1
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n/an/a 1.83E+5n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM190993
PNG
(US9670203, Compound 1.87)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc1C(F)(F)F
Show InChI InChI=1S/C31H31F3N6O4/c1-2-39-11-13-40(14-12-39)22-6-3-17(15-21(22)31(32,33)34)36-30(42)38-27-26-20-16-18(4-7-23(20)44-28(26)27)43-24-9-10-35-29-19(24)5-8-25(41)37-29/h3-4,6-7,9-10,15-16,26-28H,2,5,8,11-14H2,1H3,(H,35,37,41)(H2,36,38,42)/t26-,27-,28-/m0/s1
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n/an/a 2.27E+5n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM190876
PNG
(US9670203, Compound 1.74)
Show SMILES CCN1CCN(Cc2ccc(NC(=O)N[C@@H]3[C@H]4Oc5ccc(Oc6ccnc7NC(=O)CCc67)cc5[C@@H]34)cc2F)CC1
Show InChI InChI=1S/C31H33FN6O4/c1-2-37-11-13-38(14-12-37)17-18-3-4-19(15-23(18)32)34-31(40)36-28-27-22-16-20(5-7-24(22)42-29(27)28)41-25-9-10-33-30-21(25)6-8-26(39)35-30/h3-5,7,9-10,15-16,27-29H,2,6,8,11-14,17H2,1H3,(H,33,35,39)(H2,34,36,40)/t27-,28-,29-/m0/s1
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n/an/a 8.21E+5n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM191016
PNG
(US9670203, Compound 2.1 1-(2,4-difluorophenyl)-3-(...)
Show SMILES Fc1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccncn5)cc4[C@@H]23)c(F)c1
Show InChI InChI=1S/C20H14F2N4O3/c21-10-1-3-14(13(22)7-10)25-20(27)26-18-17-12-8-11(2-4-15(12)29-19(17)18)28-16-5-6-23-9-24-16/h1-9,17-19H,(H2,25,26,27)/t17-,18-,19-/m0/s1
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n/an/a 1.10E+6n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM186834
PNG
(US9670203, Compound 1.26)
Show SMILES CN(C)Cc1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc1
Show InChI InChI=1S/C27H27N5O4/c1-32(2)14-15-3-5-16(6-4-15)29-27(34)31-24-23-19-13-17(7-9-20(19)36-25(23)24)35-21-11-12-28-26-18(21)8-10-22(33)30-26/h3-7,9,11-13,23-25H,8,10,14H2,1-2H3,(H,28,30,33)(H2,29,31,34)/t23-,24-,25-/m0/s1
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n/an/a 2.68E+6n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM189850
PNG
(US9670203, Compound 1.63)
Show SMILES CN1CCN(Cc2ccc(NC(=O)N[C@@H]3[C@H]4Oc5ccc(Oc6ccnc7NC(=O)CCc67)cc5[C@@H]34)cc2)CC1
Show InChI InChI=1S/C30H32N6O4/c1-35-12-14-36(15-13-35)17-18-2-4-19(5-3-18)32-30(38)34-27-26-22-16-20(6-8-23(22)40-28(26)27)39-24-10-11-31-29-21(24)7-9-25(37)33-29/h2-6,8,10-11,16,26-28H,7,9,12-15,17H2,1H3,(H,31,33,37)(H2,32,34,38)/t26-,27-,28-/m0/s1
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n/an/a>5.00E+6n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%