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Patent code US9670208

Compile Data Set for Download or QSAR
Found 48 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase ERK2


(Homo sapiens (human))
BDBM193676
PNG
(US9670208, Example 295 4-(3-(cyclopropylmethyl)-[1...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1ccn2c(CC3CC3)nnc2c1
Show InChI InChI=1S/C19H19N7/c1-25-17(5-8-21-25)22-16-11-14(4-7-20-16)15-6-9-26-18(10-13-2-3-13)23-24-19(26)12-15/h4-9,11-13H,2-3,10H2,1H3,(H,20,22)
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n/an/a 0.400n/an/an/an/an/an/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193385
PNG
(US9670208, Example 57)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(Cc3cccc(Cl)c3Cl)nnc2c1
Show InChI InChI=1S/C21H16Cl2N8/c1-30-17(6-9-25-30)27-21-24-8-5-16(26-21)13-7-10-31-18(11-13)28-29-19(31)12-14-3-2-4-15(22)20(14)23/h2-11H,12H2,1H3,(H,24,26,27)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193773
PNG
(US9670208, Example 402 4-(3-(4-fluorobenzyl)-[1,2,...)
Show SMILES Fc1ccc(Cc2nnc3cc(ccn23)-c2ccnc(NC3CCOCC3)n2)cc1
Show InChI InChI=1S/C22H21FN6O/c23-17-3-1-15(2-4-17)13-20-27-28-21-14-16(6-10-29(20)21)19-5-9-24-22(26-19)25-18-7-11-30-12-8-18/h1-6,9-10,14,18H,7-8,11-13H2,(H,24,25,26)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193675
PNG
(US9670208, Example 279 N-(1-methyl-1H-pyrazol-5-yl...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1ccn2c(CC(C)(C)C)nnc2c1
Show InChI InChI=1S/C20H23N7/c1-20(2,3)13-19-25-24-18-12-15(7-10-27(18)19)14-5-8-21-16(11-14)23-17-6-9-22-26(17)4/h5-12H,13H2,1-4H3,(H,21,23)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193381
PNG
(US9670208, Example 49)
Show SMILES COc1ccc(Cc2nnc3cc(ccn23)-c2ccnc(Nc3ccnn3C)n2)cc1
Show InChI InChI=1S/C22H20N8O/c1-29-19(8-11-24-29)26-22-23-10-7-18(25-22)16-9-12-30-20(27-28-21(30)14-16)13-15-3-5-17(31-2)6-4-15/h3-12,14H,13H2,1-2H3,(H,23,25,26)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193781
PNG
(US9670208, Example 493 4-(3-((6-ethoxypyridin-3-yl...)
Show SMILES CCOc1ccc(Cc2nnc3cc(ccn23)-c2ccnc(Nc3ccnn3C)n2)cn1
Show InChI InChI=1S/C22H21N9O/c1-3-32-21-5-4-15(14-24-21)12-19-28-29-20-13-16(8-11-31(19)20)17-6-9-23-22(26-17)27-18-7-10-25-30(18)2/h4-11,13-14H,3,12H2,1-2H3,(H,23,26,27)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM191370
PNG
(US9670208, Example 35)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(Cc3cc(ccn3)C3CC3)nnc2c1
Show InChI InChI=1S/C23H21N9/c1-31-20(6-10-26-31)28-23-25-9-5-19(27-23)17-7-11-32-21(13-17)29-30-22(32)14-18-12-16(4-8-24-18)15-2-3-15/h4-13,15H,2-3,14H2,1H3,(H,25,27,28)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193672
PNG
(US9670208, Example 278 4-(3-(pyridin-2-ylmethyl)-[...)
Show SMILES C(c1nnc2cc(ccn12)-c1ccnc(NC2CCOCC2)n1)c1ccccn1
Show InChI InChI=1S/C21H21N7O/c1-2-8-22-17(3-1)14-20-27-26-19-13-15(5-10-28(19)20)18-4-9-23-21(25-18)24-16-6-11-29-12-7-16/h1-5,8-10,13,16H,6-7,11-12,14H2,(H,23,24,25)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193756
PNG
(US9670208, Example 317 4-(3-((4,4-difluorocyclohex...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(CC3CCC(F)(F)CC3)nnc2c1
Show InChI InChI=1S/C21H22F2N8/c1-30-17(5-10-25-30)27-20-24-9-4-16(26-20)15-6-11-31-18(28-29-19(31)13-15)12-14-2-7-21(22,23)8-3-14/h4-6,9-11,13-14H,2-3,7-8,12H2,1H3,(H,24,26,27)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193396
PNG
(US9670208, Example 121)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1ccn2c(nnc2c1)[C@H](O)Cc1ccccc1
Show InChI InChI=1S/C23H21N7O/c1-29-21(8-11-25-29)26-20-14-17(7-10-24-20)18-9-12-30-22(15-18)27-28-23(30)19(31)13-16-5-3-2-4-6-16/h2-12,14-15,19,31H,13H2,1H3,(H,24,26)/t19-/m1/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193776
PNG
(US9670208, Example 403 4-(3-(3-fluoro-4-methoxyben...)
Show SMILES COc1ccc(Cc2nnc3cc(ccn23)-c2ccnc(NC3CCOCC3)n2)cc1F
Show InChI InChI=1S/C23H23FN6O2/c1-31-20-3-2-15(12-18(20)24)13-21-28-29-22-14-16(5-9-30(21)22)19-4-8-25-23(27-19)26-17-6-10-32-11-7-17/h2-5,8-9,12,14,17H,6-7,10-11,13H2,1H3,(H,25,26,27)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193410
PNG
(US9670208, Example 272 4-(3-((6-methoxypyridin-3-y...)
Show SMILES COc1ccc(Cc2nnc3cc(ccn23)-c2ccnc(NC3CCOCC3)n2)cn1
Show InChI InChI=1S/C22H23N7O2/c1-30-21-3-2-15(14-24-21)12-19-27-28-20-13-16(5-9-29(19)20)18-4-8-23-22(26-18)25-17-6-10-31-11-7-17/h2-5,8-9,13-14,17H,6-7,10-12H2,1H3,(H,23,25,26)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193412
PNG
(US9670208, Example 276 N-(1-methyl-1H-pyrazol-5-yl...)
Show SMILES Cc1ccnc(Cc2nnc3cc(ccn23)-c2ccnc(Nc3ccnn3C)n2)c1
Show InChI InChI=1S/C21H19N9/c1-14-3-7-22-16(11-14)13-20-28-27-19-12-15(6-10-30(19)20)17-4-8-23-21(25-17)26-18-5-9-24-29(18)2/h3-12H,13H2,1-2H3,(H,23,25,26)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193411
PNG
(US9670208, Example 275 N-(1-methyl-1H-pyrazol-5-yl...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(Cc3cccc(n3)-c3ccccc3)nnc2c1
Show InChI InChI=1S/C26H21N9/c1-34-23(11-14-28-34)31-26-27-13-10-22(30-26)19-12-15-35-24(16-19)32-33-25(35)17-20-8-5-9-21(29-20)18-6-3-2-4-7-18/h2-16H,17H2,1H3,(H,27,30,31)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193780
PNG
(US9670208, Example 467 N-(1-(3-chloro-4-fluorophen...)
Show SMILES CC(=O)NC(Cc1nnc2cc(ccn12)-c1ccnc(Nc2ccnn2C)n1)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C24H21ClFN9O/c1-14(36)29-20(15-3-4-18(26)17(25)11-15)13-23-33-32-22-12-16(7-10-35(22)23)19-5-8-27-24(30-19)31-21-6-9-28-34(21)2/h3-12,20H,13H2,1-2H3,(H,29,36)(H,27,30,31)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193754
PNG
(US9670208, Example 306 N-(1-methyl-1H-pyrazol-5-yl...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(CS(=O)(=O)c3ccccc3)nnc2c1
Show InChI InChI=1S/C21H18N8O2S/c1-28-18(8-11-23-28)25-21-22-10-7-17(24-21)15-9-12-29-19(13-15)26-27-20(29)14-32(30,31)16-5-3-2-4-6-16/h2-13H,14H2,1H3,(H,22,24,25)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193404
PNG
(US9670208, Example 163 4-(3-(bicyclo[2.2.1]heptan-...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(CC3CC4CCC3C4)nnc2c1
Show InChI InChI=1S/C22H24N8/c1-29-19(5-8-24-29)26-22-23-7-4-18(25-22)16-6-9-30-20(12-16)27-28-21(30)13-17-11-14-2-3-15(17)10-14/h4-9,12,14-15,17H,2-3,10-11,13H2,1H3,(H,23,25,26)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193758
PNG
(US9670208, Example 379 4-(3-((1s,3s)-adamantan-1-y...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(CC34CC5CC(CC(C5)C3)C4)nnc2c1
Show InChI InChI=1S/C25H28N8/c1-32-21(3-6-27-32)29-24-26-5-2-20(28-24)19-4-7-33-22(11-19)30-31-23(33)15-25-12-16-8-17(13-25)10-18(9-16)14-25/h2-7,11,16-18H,8-10,12-15H2,1H3,(H,26,28,29)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193384
PNG
(US9670208, Example 51)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(Cc3cccc(F)c3F)nnc2c1
Show InChI InChI=1S/C21H16F2N8/c1-30-17(6-9-25-30)27-21-24-8-5-16(26-21)13-7-10-31-18(11-13)28-29-19(31)12-14-3-2-4-15(22)20(14)23/h2-11H,12H2,1H3,(H,24,26,27)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193405
PNG
(US9670208, Example 169 4-(3-isobutyl-[1,2,4]triazo...)
Show SMILES CC(C)Cc1nnc2cc(ccn12)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1S/C18H20N8/c1-12(2)10-16-23-24-17-11-13(6-9-26(16)17)14-4-7-19-18(21-14)22-15-5-8-20-25(15)3/h4-9,11-12H,10H2,1-3H3,(H,19,21,22)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193386
PNG
(US9670208, Example 67)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(Cc3ccc(F)cc3F)nnc2c1
Show InChI InChI=1S/C21H16F2N8/c1-30-18(5-8-25-30)27-21-24-7-4-17(26-21)14-6-9-31-19(28-29-20(31)11-14)10-13-2-3-15(22)12-16(13)23/h2-9,11-12H,10H2,1H3,(H,24,26,27)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193392
PNG
(US9670208, Example 115)
Show SMILES CC[C@H](C)Cc1nnc2cc(ccn12)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1S/C19H22N8/c1-4-13(2)11-17-24-25-18-12-14(7-10-27(17)18)15-5-8-20-19(22-15)23-16-6-9-21-26(16)3/h5-10,12-13H,4,11H2,1-3H3,(H,20,22,23)/t13-/m0/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193397
PNG
(US9670208, Example 123)
Show SMILES COc1ccc(Cc2nnc3cc(ccn23)-c2nc(NC3CCOCC3)ncc2F)cc1
Show InChI InChI=1S/C23H23FN6O2/c1-31-18-4-2-15(3-5-18)12-20-28-29-21-13-16(6-9-30(20)21)22-19(24)14-25-23(27-22)26-17-7-10-32-11-8-17/h2-6,9,13-14,17H,7-8,10-12H2,1H3,(H,25,26,27)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193403
PNG
(US9670208, Example 150 N-(1-methyl-1H-pyrazol-5-yl...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(CC(C)(C)C)nnc2c1
Show InChI InChI=1S/C19H22N8/c1-19(2,3)12-17-25-24-16-11-13(7-10-27(16)17)14-5-8-20-18(22-14)23-15-6-9-21-26(15)4/h5-11H,12H2,1-4H3,(H,20,22,23)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193389
PNG
(US9670208, Example 111)
Show SMILES CCOCCc1nnc2cc(ccn12)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1S/C18H20N8O/c1-3-27-11-7-16-23-24-17-12-13(6-10-26(16)17)14-4-8-19-18(21-14)22-15-5-9-20-25(15)2/h4-6,8-10,12H,3,7,11H2,1-2H3,(H,19,21,22)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193772
PNG
(US9670208, Example 398 4-(3-(2-fluorobenzyl)-[1,2,...)
Show SMILES Fc1ccccc1Cc1nnc2cc(ccn12)-c1ccnc(NC2CCOCC2)n1
Show InChI InChI=1S/C22H21FN6O/c23-18-4-2-1-3-15(18)13-20-27-28-21-14-16(6-10-29(20)21)19-5-9-24-22(26-19)25-17-7-11-30-12-8-17/h1-6,9-10,14,17H,7-8,11-13H2,(H,24,25,26)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193387
PNG
(US9670208, Example 84)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1ccn2c(Cc3ccc(F)cc3F)nnc2c1
Show InChI InChI=1S/C22H17F2N7/c1-30-20(5-8-26-30)27-19-10-14(4-7-25-19)15-6-9-31-21(11-15)28-29-22(31)12-16-2-3-17(23)13-18(16)24/h2-11,13H,12H2,1H3,(H,25,27)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193380
PNG
(US9670208, Example 40)
Show SMILES COc1ccc(Cc2nnc3cc(ccn23)-c2ccnc(Nc3ccnn3C)n2)cc1F
Show InChI InChI=1S/C22H19FN8O/c1-30-19(6-9-25-30)27-22-24-8-5-17(26-22)15-7-10-31-20(28-29-21(31)13-15)12-14-3-4-18(32-2)16(23)11-14/h3-11,13H,12H2,1-2H3,(H,24,26,27)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193394
PNG
(US9670208, Example 116)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(nnc2c1)[C@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C21H17ClN8O/c1-29-17(6-9-24-29)26-21-23-8-5-16(25-21)13-7-10-30-18(12-13)27-28-20(30)19(31)14-3-2-4-15(22)11-14/h2-12,19,31H,1H3,(H,23,25,26)/t19-/m1/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193770
PNG
(US9670208, Example 396 N-(1-methyl-1H-pyrazol-5-yl...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1ccn2c(CC3(CC3)C(F)(F)F)nnc2c1
Show InChI InChI=1S/C20H18F3N7/c1-29-16(3-8-25-29)26-15-10-13(2-7-24-15)14-4-9-30-17(11-14)27-28-18(30)12-19(5-6-19)20(21,22)23/h2-4,7-11H,5-6,12H2,1H3,(H,24,26)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193391
PNG
(US9670208, Example 113)
Show SMILES CN1CC(CC(C1)c1nnc2cc(ccn12)-c1ccnc(Nc2ccnn2C)n1)Oc1c(F)cccc1F
Show InChI InChI=1S/C26H25F2N9O/c1-35-14-17(12-18(15-35)38-24-19(27)4-3-5-20(24)28)25-34-33-23-13-16(8-11-37(23)25)21-6-9-29-26(31-21)32-22-7-10-30-36(22)2/h3-11,13,17-18H,12,14-15H2,1-2H3,(H,29,31,32)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193388
PNG
(US9670208, Example 108)
Show SMILES COC(Cc1nnc2cc(ccn12)-c1ccnc(Nc2ccnn2C)n1)C(F)(F)F
Show InChI InChI=1S/C18H17F3N8O/c1-28-14(4-7-23-28)25-17-22-6-3-12(24-17)11-5-8-29-15(9-11)26-27-16(29)10-13(30-2)18(19,20)21/h3-9,13H,10H2,1-2H3,(H,22,24,25)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193755
PNG
(US9670208, Example 307 4-(3-((cyclopentylthio)meth...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(CSC3CCCC3)nnc2c1
Show InChI InChI=1S/C20H22N8S/c1-27-17(7-10-22-27)24-20-21-9-6-16(23-20)14-8-11-28-18(12-14)25-26-19(28)13-29-15-4-2-3-5-15/h6-12,15H,2-5,13H2,1H3,(H,21,23,24)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193757
PNG
(US9670208, Example 377 4-(3-((dimethylamino)(4-flu...)
Show SMILES CN(C)C(c1nnc2cc(ccn12)-c1ccnc(Nc2ccnn2C)n1)c1ccc(F)cc1
Show InChI InChI=1S/C23H22FN9/c1-31(2)21(15-4-6-17(24)7-5-15)22-30-29-20-14-16(10-13-33(20)22)18-8-11-25-23(27-18)28-19-9-12-26-32(19)3/h4-14,21H,1-3H3,(H,25,27,28)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193409
PNG
(US9670208, Example 258 (E)-4-(3-(but-1-en-1-yl)-[1...)
Show SMILES CC\C=C/c1nnc2cc(ccn12)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1S/C18H18N8/c1-3-4-5-16-23-24-17-12-13(8-11-26(16)17)14-6-9-19-18(21-14)22-15-7-10-20-25(15)2/h4-12H,3H2,1-2H3,(H,19,21,22)/b5-4-
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193406
PNG
(US9670208, Example 192 4-(3-(isochroman-1-yl)-[1,2...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(nnc2c1)C1OCCc2ccccc12
Show InChI InChI=1S/C23H20N8O/c1-30-19(7-11-25-30)27-23-24-10-6-18(26-23)16-8-12-31-20(14-16)28-29-22(31)21-17-5-3-2-4-15(17)9-13-32-21/h2-8,10-12,14,21H,9,13H2,1H3,(H,24,26,27)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193402
PNG
(US9670208, Example 140 (2,6-difluorophenyl)(2-(7-(...)
Show SMILES Fc1cccc(F)c1C(=O)N1CCOC(C1)c1nnc2cc(ccn12)-c1ccnc(NC2CCOCC2)n1
Show InChI InChI=1S/C26H25F2N7O3/c27-18-2-1-3-19(28)23(18)25(36)34-10-13-38-21(15-34)24-33-32-22-14-16(5-9-35(22)24)20-4-8-29-26(31-20)30-17-6-11-37-12-7-17/h1-5,8-9,14,17,21H,6-7,10-13,15H2,(H,29,30,31)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193777
PNG
(US9670208, Example 411 4-([1,2,4]triazolo[4,3-a]py...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2cnnc2c1
Show InChI InChI=1S/C14H12N8/c1-21-12(3-6-17-21)19-14-15-5-2-11(18-14)10-4-7-22-9-16-20-13(22)8-10/h2-9H,1H3,(H,15,18,19)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193390
PNG
(US9670208, Example 112)
Show SMILES Fc1c(ccn2c(Cc3ccc(Cl)cc3)nnc12)-c1ccnc(NC2CCOCC2)c1
Show InChI InChI=1S/C23H21ClFN5O/c24-17-3-1-15(2-4-17)13-21-28-29-23-22(25)19(6-10-30(21)23)16-5-9-26-20(14-16)27-18-7-11-31-12-8-18/h1-6,9-10,14,18H,7-8,11-13H2,(H,26,27)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193407
PNG
(US9670208, Example 195 (S)-4-(3-(methoxy(phenyl)me...)
Show SMILES CO[C@H](c1nnc2cc(ccn12)-c1ccnc(NC2CCOCC2)n1)c1ccccc1
Show InChI InChI=1S/C23H24N6O2/c1-30-21(16-5-3-2-4-6-16)22-28-27-20-15-17(8-12-29(20)22)19-7-11-24-23(26-19)25-18-9-13-31-14-10-18/h2-8,11-12,15,18,21H,9-10,13-14H2,1H3,(H,24,25,26)/t21-/m0/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193769
PNG
(US9670208, Example 387 4-(3-(morpholin-2-yl)-[1,2,...)
Show SMILES C1COC(CN1)c1nnc2cc(ccn12)-c1ccnc(NC2CCOCC2)n1
Show InChI InChI=1S/C19H23N7O2/c1-5-21-19(22-14-3-8-27-9-4-14)23-15(1)13-2-7-26-17(11-13)24-25-18(26)16-12-20-6-10-28-16/h1-2,5,7,11,14,16,20H,3-4,6,8-10,12H2,(H,21,22,23)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193778
PNG
(US9670208, Example 419 4-(3-(1-(4-fluorophenyl)-5-...)
Show SMILES Cc1cc(nn1-c1ccc(F)cc1)-c1nnc2cc(ccn12)-c1ccnc(Nc2cnn(C)c2)n1
Show InChI InChI=1S/C24H19FN10/c1-15-11-21(32-35(15)19-5-3-17(25)4-6-19)23-31-30-22-12-16(8-10-34(22)23)20-7-9-26-24(29-20)28-18-13-27-33(2)14-18/h3-14H,1-2H3,(H,26,28,29)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193401
PNG
(US9670208, Example 136 1-methyl-4-phenyl-5-(7-(2-(...)
Show SMILES CN1C(C(CC1=O)c1ccccc1)c1nnc2cc(ccn12)-c1ccnc(NC2CCOCC2)n1
Show InChI InChI=1S/C26H27N7O2/c1-32-23(34)16-20(17-5-3-2-4-6-17)24(32)25-31-30-22-15-18(8-12-33(22)25)21-7-11-27-26(29-21)28-19-9-13-35-14-10-19/h2-8,11-12,15,19-20,24H,9-10,13-14,16H2,1H3,(H,27,28,29)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193782
PNG
(US9670208, Example 512 (7-(2-((1-methyl-1H-pyrazol...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(nnc2c1)C(=O)C1CCCC1
Show InChI InChI=1S/C20H20N8O/c1-27-16(7-10-22-27)24-20-21-9-6-15(23-20)14-8-11-28-17(12-14)25-26-19(28)18(29)13-4-2-3-5-13/h6-13H,2-5H2,1H3,(H,21,23,24)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193408
PNG
(US9670208, Example 211 4-(3-(2-fluorobenzyl)-[1,2,...)
Show SMILES CC(C)Nc1nccc(n1)-c1ccn2c(Cc3ccccc3F)nnc2c1
Show InChI InChI=1S/C20H19FN6/c1-13(2)23-20-22-9-7-17(24-20)15-8-10-27-18(25-26-19(27)12-15)11-14-5-3-4-6-16(14)21/h3-10,12-13H,11H2,1-2H3,(H,22,23,24)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193400
PNG
(US9670208, Example 132 4-(3-(1-((5-fluoro-2-methox...)
Show SMILES COc1ncc(F)cc1CN1CCCC(C1)c1nnc2cc(ccn12)-c1ccnc(NC2CCOCC2)n1
Show InChI InChI=1S/C27H31FN8O2/c1-37-26-20(13-21(28)15-30-26)17-35-9-2-3-19(16-35)25-34-33-24-14-18(5-10-36(24)25)23-4-8-29-27(32-23)31-22-6-11-38-12-7-22/h4-5,8,10,13-15,19,22H,2-3,6-7,9,11-12,16-17H2,1H3,(H,29,31,32)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193398
PNG
(US9670208, Example 131 4-(3-(piperidin-3-yl)-[1,2,...)
Show SMILES C1CNCC(C1)c1nnc2cc(ccn12)-c1ccnc(NC2CCOCC2)n1
Show InChI InChI=1S/C20H25N7O/c1-2-15(13-21-7-1)19-26-25-18-12-14(4-9-27(18)19)17-3-8-22-20(24-17)23-16-5-10-28-11-6-16/h3-4,8-9,12,15-16,21H,1-2,5-7,10-11,13H2,(H,22,23,24)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 224n/an/an/an/an/an/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193783
PNG
(US9670208, Example 563 2-cyclopropyl-1-(7-(2-((1-m...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(CC(C)(O)C3CC3)nnc2c1
Show InChI InChI=1S/C20H22N8O/c1-20(29,14-3-4-14)12-18-26-25-17-11-13(7-10-28(17)18)15-5-8-21-19(23-15)24-16-6-9-22-27(16)2/h5-11,14,29H,3-4,12H2,1-2H3,(H,21,23,24)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 661n/an/an/an/an/an/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%