BindingDB logo
myBDB logout

Patent code US9670210

Compile Data Set for Download or QSAR
Found 116 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194130
PNG
(US9670210, Example 32 1-{[4-(4-fluorobenzyl)-4-({[...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(Cc3ccc(F)cc3)CC2)CCC1
Show InChI InChI=1S/C28H35FN2O2/c29-23-9-7-21(8-10-23)18-27(19-30-25-17-24(25)22-5-2-1-3-6-22)13-15-31(16-14-27)20-28(26(32)33)11-4-12-28/h1-3,5-10,24-25,30H,4,11-20H2,(H,32,33)/t24?,25-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194245
PNG
(US9670210, Example 45 1-{[4-methyl-4-({[(1R,2S)-2-...)
Show SMILES CC1(CN[C@@H]2CC2c2ccccc2)CCN(CC2(CCC2)C(O)=O)CC1
Show InChI InChI=1S/C22H32N2O2/c1-21(15-23-19-14-18(19)17-6-3-2-4-7-17)10-12-24(13-11-21)16-22(20(25)26)8-5-9-22/h2-4,6-7,18-19,23H,5,8-16H2,1H3,(H,25,26)/t18?,19-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194551
PNG
(US9670210, Example 53 1-{[4-[4-(cyanomethyl)benzyl...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(Cc3ccc(CC#N)cc3)CC2)CC1
Show InChI InChI=1S/C29H35N3O2/c30-15-10-22-6-8-23(9-7-22)19-28(20-31-26-18-25(26)24-4-2-1-3-5-24)13-16-32(17-14-28)21-29(11-12-29)27(33)34/h1-9,25-26,31H,10-14,16-21H2,(H,33,34)/t25?,26-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194669
PNG
(US9670210, Example 63 1-{[4-({[(1R,2S)-2-(4-fluoro...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccc(F)cc2)CCN(CC2(CCC2)C(O)=O)CC1
Show InChI InChI=1S/C23H33FN2O3/c1-29-16-22(14-25-20-13-19(20)17-3-5-18(24)6-4-17)9-11-26(12-10-22)15-23(21(27)28)7-2-8-23/h3-6,19-20,25H,2,7-16H2,1H3,(H,27,28)/t19?,20-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194673
PNG
(US9670210, Example 65 1-{[4-({[(1R,2S)-2-(3,4-difl...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccc(F)c(F)c2)CCN(CC2(CCC2)C(O)=O)CC1
Show InChI InChI=1S/C23H32F2N2O3/c1-30-15-22(7-9-27(10-8-22)14-23(21(28)29)5-2-6-23)13-26-20-12-17(20)16-3-4-18(24)19(25)11-16/h3-4,11,17,20,26H,2,5-10,12-15H2,1H3,(H,28,29)/t17?,20-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194679
PNG
(US9670210, Example 68 1-{[4-(methoxymethyl)-4-(1-{...)
Show SMILES COCC1(CCN(CC2(CCC2)C(O)=O)CC1)C(C)N[C@@H]1C[C@H]1c1ccccc1
Show InChI InChI=1S/C24H36N2O3/c1-18(25-21-15-20(21)19-7-4-3-5-8-19)24(17-29-2)11-13-26(14-12-24)16-23(22(27)28)9-6-10-23/h3-5,7-8,18,20-21,25H,6,9-17H2,1-2H3,(H,27,28)/t18?,20-,21+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194693
PNG
(US9670210, Example 79 1-{[4-[(2-cyanophenoxy)methy...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(COc3ccccc3C#N)CC2)CC1
Show InChI InChI=1S/C28H33N3O3/c29-17-22-8-4-5-9-25(22)34-20-27(18-30-24-16-23(24)21-6-2-1-3-7-21)12-14-31(15-13-27)19-28(10-11-28)26(32)33/h1-9,23-24,30H,10-16,18-20H2,(H,32,33)/t23?,24-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194696
PNG
(US9670210, Example 82 1-{[4-[(4-cyano-2-fluorophen...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(COc3ccc(cc3F)C#N)CC2)CC1
Show InChI InChI=1S/C28H32FN3O3/c29-23-14-20(16-30)6-7-25(23)35-19-27(17-31-24-15-22(24)21-4-2-1-3-5-21)10-12-32(13-11-27)18-28(8-9-28)26(33)34/h1-7,14,22,24,31H,8-13,15,17-19H2,(H,33,34)/t22?,24-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194707
PNG
(US9670210, Example 93 1-{[4-[(cyclobutylmethoxy)me...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(COCC3CCC3)CC2)CCC1
Show InChI InChI=1S/C27H40N2O3/c30-25(31)27(10-5-11-27)19-29-14-12-26(13-15-29,20-32-17-21-6-4-7-21)18-28-24-16-23(24)22-8-2-1-3-9-22/h1-3,8-9,21,23-24,28H,4-7,10-20H2,(H,30,31)/t23?,24-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194710
PNG
(US9670210, Example 96 1-{[4-[(5-fluoropyridin-2-yl...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(Cc3ccc(F)cn3)CC2)CC1
Show InChI InChI=1S/C26H32FN3O2/c27-20-6-7-21(28-16-20)15-25(17-29-23-14-22(23)19-4-2-1-3-5-19)10-12-30(13-11-25)18-26(8-9-26)24(31)32/h1-7,16,22-23,29H,8-15,17-18H2,(H,31,32)/t22?,23-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194717
PNG
(US9670210, Example 103 2-(4-{[4-(methoxymethyl)-4-...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C(=O)c1cnn(CCO)c1
Show InChI InChI=1S/C23H32N4O3/c1-30-17-23(16-24-21-13-20(21)18-5-3-2-4-6-18)7-9-26(10-8-23)22(29)19-14-25-27(15-19)11-12-28/h2-6,14-15,20-21,24,28H,7-13,16-17H2,1H3/t20?,21-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194719
PNG
(US9670210, Example 105 (1R,2S)N-({4-(methoxymethy...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C(=O)c1cnn(C)c1
Show InChI InChI=1S/C22H30N4O2/c1-25-14-18(13-24-25)21(27)26-10-8-22(9-11-26,16-28-2)15-23-20-12-19(20)17-6-4-3-5-7-17/h3-7,13-14,19-20,23H,8-12,15-16H2,1-2H3/t19?,20-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194093
PNG
(US9670210, Example 19 N-(2-Fluorophenyl)-3-{[(tran...)
Show SMILES Fc1ccccc1NC(=O)N1CC(CNC2CC2c2ccccc2)C1
Show InChI InChI=1S/C20H22FN3O/c21-17-8-4-5-9-18(17)23-20(25)24-12-14(13-24)11-22-19-10-16(19)15-6-2-1-3-7-15/h1-9,14,16,19,22H,10-13H2,(H,23,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194107
PNG
(US9670210, Example 23 N-(3-Methoxyphenyl)-3-{[(tra...)
Show SMILES COc1cccc(NC(=O)N2CC(CNC3CC3c3ccccc3)C2)c1
Show InChI InChI=1S/C21H25N3O2/c1-26-18-9-5-8-17(10-18)23-21(25)24-13-15(14-24)12-22-20-11-19(20)16-6-3-2-4-7-16/h2-10,15,19-20,22H,11-14H2,1H3,(H,23,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194201
PNG
(US9670210, Example 35 1-{[4-(methoxymethyl)-4-({[(...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC2(CC2)C(O)=O)CC1
Show InChI InChI=1S/C22H32N2O3/c1-27-16-21(14-23-19-13-18(19)17-5-3-2-4-6-17)9-11-24(12-10-21)15-22(7-8-22)20(25)26/h2-6,18-19,23H,7-16H2,1H3,(H,25,26)/t18?,19-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194239
PNG
(US9670210, Example 40 6-{[4-(methoxymethyl)-4-({[(...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C(=O)c1ccc(N)nn1
Show InChI InChI=1S/C22H29N5O2/c1-29-15-22(14-24-19-13-17(19)16-5-3-2-4-6-16)9-11-27(12-10-22)21(28)18-7-8-20(23)26-25-18/h2-8,17,19,24H,9-15H2,1H3,(H2,23,26)/t17?,19-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194240
PNG
(US9670210, Example 41 (1R,2S)N-({4-(methoxymethyl...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C(=O)C1CCN(C)CC1
Show InChI InChI=1S/C24H37N3O2/c1-26-12-8-20(9-13-26)23(28)27-14-10-24(11-15-27,18-29-2)17-25-22-16-21(22)19-6-4-3-5-7-19/h3-7,20-22,25H,8-18H2,1-2H3/t21?,22-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194234
PNG
(US9670210, Example 37 1-{[4-(methoxymethyl)-4-({[(...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC2(CCCC2)C(O)=O)CC1
Show InChI InChI=1S/C24H36N2O3/c1-29-18-23(16-25-21-15-20(21)19-7-3-2-4-8-19)11-13-26(14-12-23)17-24(22(27)28)9-5-6-10-24/h2-4,7-8,20-21,25H,5-6,9-18H2,1H3,(H,27,28)/t20?,21-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194643
PNG
(US9670210, Example 60 (3R)-1-{[4-(methoxymethyl)-4...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C(=O)N1CC[C@@H](O)C1
Show InChI InChI=1S/C22H33N3O3/c1-28-16-22(15-23-20-13-19(20)17-5-3-2-4-6-17)8-11-24(12-9-22)21(27)25-10-7-18(26)14-25/h2-6,18-20,23,26H,7-16H2,1H3/t18-,19?,20-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194651
PNG
(US9670210, Example 61 (3S)-1-{[4-(methoxymethyl)-4...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C(=O)N1CC[C@H](O)C1
Show InChI InChI=1S/C22H33N3O3/c1-28-16-22(15-23-20-13-19(20)17-5-3-2-4-6-17)8-11-24(12-9-22)21(27)25-10-7-18(26)14-25/h2-6,18-20,23,26H,7-16H2,1H3/t18-,19?,20+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194678
PNG
(US9670210, Example 67 1-{[4-(methoxymethyl)-4-({[2...)
Show SMILES COCC1(CNC2CC2c2ccc(OC)cc2)CCN(CC2(CCC2)C(O)=O)CC1
Show InChI InChI=1S/C24H36N2O4/c1-29-17-23(10-12-26(13-11-23)16-24(22(27)28)8-3-9-24)15-25-21-14-20(21)18-4-6-19(30-2)7-5-18/h4-7,20-21,25H,3,8-17H2,1-2H3,(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194685
PNG
(US9670210, Example 71 1-{[4-(ethoxymethyl)-4-({[(1...)
Show SMILES CCOCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC2(CCC2)C(O)=O)CC1
Show InChI InChI=1S/C24H36N2O3/c1-2-29-18-23(16-25-21-15-20(21)19-7-4-3-5-8-19)11-13-26(14-12-23)17-24(22(27)28)9-6-10-24/h3-5,7-8,20-21,25H,2,6,9-18H2,1H3,(H,27,28)/t20?,21-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194681
PNG
(US9670210, Example 69 1-{[4-[(6-methoxypyridin-3-y...)
Show SMILES COc1ccc(CC2(CN[C@@H]3CC3c3ccccc3)CCN(CC3(CC3)C(O)=O)CC2)cn1
Show InChI InChI=1S/C27H35N3O3/c1-33-24-8-7-20(17-28-24)16-26(18-29-23-15-22(23)21-5-3-2-4-6-21)11-13-30(14-12-26)19-27(9-10-27)25(31)32/h2-8,17,22-23,29H,9-16,18-19H2,1H3,(H,31,32)/t22?,23-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194691
PNG
(US9670210, Example 77 1-{[4-[(3-fluorophenoxy)meth...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(COc3cccc(F)c3)CC2)CC1
Show InChI InChI=1S/C27H33FN2O3/c28-21-7-4-8-22(15-21)33-19-26(17-29-24-16-23(24)20-5-2-1-3-6-20)11-13-30(14-12-26)18-27(9-10-27)25(31)32/h1-8,15,23-24,29H,9-14,16-19H2,(H,31,32)/t23?,24-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM193838
PNG
(US9670210, Example 2 N-{[1-(4-Fluorobenzyl)azetidi...)
Show SMILES Fc1ccc(CN2CC(CNC3CC3c3ccccc3)C2)cc1
Show InChI InChI=1S/C20H23FN2/c21-18-8-6-15(7-9-18)12-23-13-16(14-23)11-22-20-10-19(20)17-4-2-1-3-5-17/h1-9,16,19-20,22H,10-14H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM193843
PNG
(US9670210, Example 5 1-(4-Fluorobenzyl)-N-(trans-2...)
Show SMILES Fc1ccc(CN2CCC(CC2)NC2CC2c2ccccc2)cc1
Show InChI InChI=1S/C21H25FN2/c22-18-8-6-16(7-9-18)15-24-12-10-19(11-13-24)23-21-14-20(21)17-4-2-1-3-5-17/h1-9,19-21,23H,10-15H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM193872
PNG
(US9670210, Example 12 1-[(3-{[(trans-2-Phenylcyclo...)
Show SMILES O=C(N1CC(CNC2CC2c2ccccc2)C1)N1CCC(CC1)C#N
Show InChI InChI=1S/C20H26N4O/c21-11-15-6-8-23(9-7-15)20(25)24-13-16(14-24)12-22-19-10-18(19)17-4-2-1-3-5-17/h1-5,15-16,18-19,22H,6-10,12-14H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM193893
PNG
(US9670210, Example 17 4-Phenyl-1-[(3-{[(trans-2-ph...)
Show SMILES OC1(CCN(CC1)C(=O)N1CC(CNC2CC2c2ccccc2)C1)c1ccccc1
Show InChI InChI=1S/C25H31N3O2/c29-24(27-13-11-25(30,12-14-27)21-9-5-2-6-10-21)28-17-19(18-28)16-26-23-15-22(23)20-7-3-1-4-8-20/h1-10,19,22-23,26,30H,11-18H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194233
PNG
(US9670210, Example 36 1-{[4-(methoxymethyl)-4-({[(...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC2(CCC2)C(O)=O)CC1
Show InChI InChI=1S/C23H34N2O3/c1-28-17-22(15-24-20-14-19(20)18-6-3-2-4-7-18)10-12-25(13-11-22)16-23(21(26)27)8-5-9-23/h2-4,6-7,19-20,24H,5,8-17H2,1H3,(H,26,27)/t19?,20-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194243
PNG
(US9670210, Example 43 (1R,2S)N-({4-(methoxymethyl...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C(=O)N1CCN(C)CC1
Show InChI InChI=1S/C23H36N4O2/c1-25-12-14-27(15-13-25)22(28)26-10-8-23(9-11-26,18-29-2)17-24-21-16-20(21)19-6-4-3-5-7-19/h3-7,20-21,24H,8-18H2,1-2H3/t20?,21-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194263
PNG
(US9670210, Example 50 4-{[4-methyl-4-({[(1R,2S)-2-...)
Show SMILES CC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C(=O)c1c[nH]nc1N
Show InChI InChI=1S/C20H27N5O/c1-20(13-22-17-11-15(17)14-5-3-2-4-6-14)7-9-25(10-8-20)19(26)16-12-23-24-18(16)21/h2-6,12,15,17,22H,7-11,13H2,1H3,(H3,21,23,24)/t15?,17-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194552
PNG
(US9670210, Example 54 1-{[4-[4-(cyanomethyl)benzyl...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(Cc3ccc(CC#N)cc3)CC2)CCC1
Show InChI InChI=1S/C30H37N3O2/c31-16-11-23-7-9-24(10-8-23)20-29(21-32-27-19-26(27)25-5-2-1-3-6-25)14-17-33(18-15-29)22-30(28(34)35)12-4-13-30/h1-3,5-10,26-27,32H,4,11-15,17-22H2,(H,34,35)/t26?,27-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194567
PNG
(US9670210, Example 56 1-{[4-(3-cyanobenzyl)-4-({[(...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(Cc3cccc(c3)C#N)CC2)CC1
Show InChI InChI=1S/C28H33N3O2/c29-18-22-6-4-5-21(15-22)17-27(19-30-25-16-24(25)23-7-2-1-3-8-23)11-13-31(14-12-27)20-28(9-10-28)26(32)33/h1-8,15,24-25,30H,9-14,16-17,19-20H2,(H,32,33)/t24?,25-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194686
PNG
(US9670210, Example 72 1-{[4-[(benzyloxy)methyl]-4-...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(COCc3ccccc3)CC2)CC1
Show InChI InChI=1S/C28H36N2O3/c31-26(32)28(11-12-28)20-30-15-13-27(14-16-30,21-33-18-22-7-3-1-4-8-22)19-29-25-17-24(25)23-9-5-2-6-10-23/h1-10,24-25,29H,11-21H2,(H,31,32)/t24?,25-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194694
PNG
(US9670210, Example 80 1-{[4-[(3-cyanophenoxy)methy...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(COc3cccc(c3)C#N)CC2)CC1
Show InChI InChI=1S/C28H33N3O3/c29-17-21-5-4-8-23(15-21)34-20-27(18-30-25-16-24(25)22-6-2-1-3-7-22)11-13-31(14-12-27)19-28(9-10-28)26(32)33/h1-8,15,24-25,30H,9-14,16,18-20H2,(H,32,33)/t24?,25-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194698
PNG
(US9670210, Example 84 1-{[4-[(3-cyanophenoxy)methy...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(COc3cccc(c3)C#N)CC2)CCC1
Show InChI InChI=1S/C29H35N3O3/c30-18-22-6-4-9-24(16-22)35-21-28(19-31-26-17-25(26)23-7-2-1-3-8-23)12-14-32(15-13-28)20-29(27(33)34)10-5-11-29/h1-4,6-9,16,25-26,31H,5,10-15,17,19-21H2,(H,33,34)/t25?,26-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194706
PNG
(US9670210, Example 92 1-{[4-[(cyclobutylmethoxy)me...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(COCC3CCC3)CC2)CC1
Show InChI InChI=1S/C26H38N2O3/c29-24(30)26(9-10-26)18-28-13-11-25(12-14-28,19-31-16-20-5-4-6-20)17-27-23-15-22(23)21-7-2-1-3-8-21/h1-3,7-8,20,22-23,27H,4-6,9-19H2,(H,29,30)/t22?,23-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194711
PNG
(US9670210, Example 97 1-{[4-[(5-fluoropyridin-2-yl...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(Cc3ccc(F)cn3)CC2)CCC1
Show InChI InChI=1S/C27H34FN3O2/c28-21-7-8-22(29-17-21)16-26(18-30-24-15-23(24)20-5-2-1-3-6-20)11-13-31(14-12-26)19-27(25(32)33)9-4-10-27/h1-3,5-8,17,23-24,30H,4,9-16,18-19H2,(H,32,33)/t23?,24-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194726
PNG
(US9670210, Example 112 1-{[4-(methoxymethyl)-4-({[...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C(=O)N1CCC(O)CC1
Show InChI InChI=1S/C23H35N3O3/c1-29-17-23(16-24-21-15-20(21)18-5-3-2-4-6-18)9-13-26(14-10-23)22(28)25-11-7-19(27)8-12-25/h2-6,19-21,24,27H,7-17H2,1H3/t20?,21-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM193871
PNG
(US9670210, Example 11 (5S)-2-(cis-4-Hydroxycyclohe...)
Show SMILES O[C@H]1CCC(CC1)N1CC[C@]2(CCCN(C2)C(=O)N2CC(CNC3CC3c3ccccc3)C2)C1=O
Show InChI InChI=1S/C28H40N4O3/c33-23-9-7-22(8-10-23)32-14-12-28(26(32)34)11-4-13-30(19-28)27(35)31-17-20(18-31)16-29-25-15-24(25)21-5-2-1-3-6-21/h1-3,5-6,20,22-25,29,33H,4,7-19H2/t22?,23-,24?,25?,28-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM193846
PNG
(US9670210, Example 6 4-[(3-{[(trans-2-Phenylcyclop...)
Show SMILES N#Cc1ccc(CN2CC(CNC3CC3c3ccccc3)C2)cc1
Show InChI InChI=1S/C21H23N3/c22-11-16-6-8-17(9-7-16)13-24-14-18(15-24)12-23-21-10-20(21)19-4-2-1-3-5-19/h1-9,18,20-21,23H,10,12-15H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM193877
PNG
(US9670210, Example 14 N-({1-[(3-Phenoxypiperidin-1...)
Show SMILES O=C(N1CC(CNC2CC2c2ccccc2)C1)N1CCCC(C1)Oc1ccccc1
Show InChI InChI=1S/C25H31N3O2/c29-25(27-13-7-12-22(18-27)30-21-10-5-2-6-11-21)28-16-19(17-28)15-26-24-14-23(24)20-8-3-1-4-9-20/h1-6,8-11,19,22-24,26H,7,12-18H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM193878
PNG
(US9670210, Example 15 N-({1-[(3-Methoxypiperidin-1...)
Show SMILES COC1CCCN(C1)C(=O)N1CC(CNC2CC2c2ccccc2)C1
Show InChI InChI=1S/C20H29N3O2/c1-25-17-8-5-9-22(14-17)20(24)23-12-15(13-23)11-21-19-10-18(19)16-6-3-2-4-7-16/h2-4,6-7,15,17-19,21H,5,8-14H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194088
PNG
(US9670210, Example 18 N-({1-[(5-Fluoro-1,2-dihydro...)
Show SMILES Fc1ccc2NCC3(CCN(CC3)C(=O)N3CC(CNC4CC4c4ccccc4)C3)c2c1
Show InChI InChI=1S/C26H31FN4O/c27-20-6-7-23-22(12-20)26(17-29-23)8-10-30(11-9-26)25(32)31-15-18(16-31)14-28-24-13-21(24)19-4-2-1-3-5-19/h1-7,12,18,21,24,28-29H,8-11,13-17H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194115
PNG
(US9670210, Example 26 3-[(3-{[(trans-2-Phenylcyclo...)
Show SMILES O=C(N1CC(CNC2CC2c2ccccc2)C1)c1cccc(c1)C#N
Show InChI InChI=1S/C21H21N3O/c22-11-15-5-4-8-18(9-15)21(25)24-13-16(14-24)12-23-20-10-19(20)17-6-2-1-3-7-17/h1-9,16,19-20,23H,10,12-14H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194117
PNG
(US9670210, Example 28 N-{[1-(4-Fluorobenzoyl)azeti...)
Show SMILES Fc1ccc(cc1)C(=O)N1CC(CNC2CC2c2ccccc2)C1
Show InChI InChI=1S/C20H21FN2O/c21-17-8-6-16(7-9-17)20(24)23-12-14(13-23)11-22-19-10-18(19)15-4-2-1-3-5-15/h1-9,14,18-19,22H,10-13H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194109
PNG
(US9670210, Example 25 4-[(3-{[(trans-2-Phenylcyclo...)
Show SMILES O=C(N1CC(CNC2CC2c2ccccc2)C1)c1ccc(cc1)C#N
Show InChI InChI=1S/C21H21N3O/c22-11-15-6-8-18(9-7-15)21(25)24-13-16(14-24)12-23-20-10-19(20)17-4-2-1-3-5-17/h1-9,16,19-20,23H,10,12-14H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194247
PNG
(US9670210, Example 47 (1R,2S)N-({4-methyl-1-[(1-m...)
Show SMILES Cn1cnc(c1)C(=O)N1CCC(C)(CN[C@@H]2CC2c2ccccc2)CC1
Show InChI InChI=1S/C21H28N4O/c1-21(14-22-18-12-17(18)16-6-4-3-5-7-16)8-10-25(11-9-21)20(26)19-13-24(2)15-23-19/h3-7,13,15,17-18,22H,8-12,14H2,1-2H3/t17?,18-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194553
PNG
(US9670210, Example 55 1-{[4-(4-cyanobenzyl)-4-({[(...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(Cc3ccc(cc3)C#N)CC2)CC1
Show InChI InChI=1S/C28H33N3O2/c29-18-22-8-6-21(7-9-22)17-27(19-30-25-16-24(25)23-4-2-1-3-5-23)12-14-31(15-13-27)20-28(10-11-28)26(32)33/h1-9,24-25,30H,10-17,19-20H2,(H,32,33)/t24?,25-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194675
PNG
(US9670210, Example 66 1-{[4-(methoxymethyl)-4-({[2...)
Show SMILES COCC1(CNC2CC2c2ccccc2OC)CCN(CC2(CCC2)C(O)=O)CC1
Show InChI InChI=1S/C24H36N2O4/c1-29-17-23(10-12-26(13-11-23)16-24(22(27)28)8-5-9-24)15-25-20-14-19(20)18-6-3-4-7-21(18)30-2/h3-4,6-7,19-20,25H,5,8-17H2,1-2H3,(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194683
PNG
(US9670210, Example 70 1-{[4-(ethoxymethyl)-4-({[(1...)
Show SMILES CCOCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC2(CC2)C(O)=O)CC1
Show InChI InChI=1S/C23H34N2O3/c1-2-28-17-22(15-24-20-14-19(20)18-6-4-3-5-7-18)10-12-25(13-11-22)16-23(8-9-23)21(26)27/h3-7,19-20,24H,2,8-17H2,1H3,(H,26,27)/t19?,20-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194695
PNG
(US9670210, Example 81 1-{[4-[(4-cyanophenoxy)methy...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(COc3ccc(cc3)C#N)CC2)CC1
Show InChI InChI=1S/C28H33N3O3/c29-17-21-6-8-23(9-7-21)34-20-27(18-30-25-16-24(25)22-4-2-1-3-5-22)12-14-31(15-13-27)19-28(10-11-28)26(32)33/h1-9,24-25,30H,10-16,18-20H2,(H,32,33)/t24?,25-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194700
PNG
(US9670210, Example 86 1-{[4-[(4-cyano-2-fluorophen...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(COc3ccc(cc3F)C#N)CC2)CCC1
Show InChI InChI=1S/C29H34FN3O3/c30-24-15-21(17-31)7-8-26(24)36-20-28(18-32-25-16-23(25)22-5-2-1-3-6-22)11-13-33(14-12-28)19-29(27(34)35)9-4-10-29/h1-3,5-8,15,23,25,32H,4,9-14,16,18-20H2,(H,34,35)/t23?,25-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194708
PNG
(US9670210, Example 94 1-{[4-[(cyclohexyloxy)methyl...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(COC3CCCCC3)CC2)CC1
Show InChI InChI=1S/C27H40N2O3/c30-25(31)27(11-12-27)19-29-15-13-26(14-16-29,20-32-22-9-5-2-6-10-22)18-28-24-17-23(24)21-7-3-1-4-8-21/h1,3-4,7-8,22-24,28H,2,5-6,9-20H2,(H,30,31)/t23?,24-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194716
PNG
(US9670210, Example 102 1-{[4-(methoxymethyl)-4-({[...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C(=O)C1(CC1)C#N
Show InChI InChI=1S/C22H29N3O2/c1-27-16-21(15-24-19-13-18(19)17-5-3-2-4-6-17)9-11-25(12-10-21)20(26)22(14-23)7-8-22/h2-6,18-19,24H,7-13,15-16H2,1H3/t18?,19-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194728
PNG
(US9670210, Example 114 (1R,2S)N-({4-(methoxymethy...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)S(=O)(=O)c1cnn(C)c1
Show InChI InChI=1S/C21H30N4O3S/c1-24-14-18(13-23-24)29(26,27)25-10-8-21(9-11-25,16-28-2)15-22-20-12-19(20)17-6-4-3-5-7-17/h3-7,13-14,19-20,22H,8-12,15-16H2,1-2H3/t19?,20-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194729
PNG
(US9670210, Example 115 (1R,2S)N-({4-(methoxymethy...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)S(=O)(=O)c1ccnn1C
Show InChI InChI=1S/C21H30N4O3S/c1-24-20(8-11-23-24)29(26,27)25-12-9-21(10-13-25,16-28-2)15-22-19-14-18(19)17-6-4-3-5-7-17/h3-8,11,18-19,22H,9-10,12-16H2,1-2H3/t18?,19-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM193875
PNG
(US9670210, Example 13 Trans-2-phenyl-N-[(1-{[4-(tr...)
Show SMILES FC(F)(F)C1CCN(CC1)C(=O)N1CC(CNC2CC2c2ccccc2)C1
Show InChI InChI=1S/C20H26F3N3O/c21-20(22,23)16-6-8-25(9-7-16)19(27)26-12-14(13-26)11-24-18-10-17(18)15-4-2-1-3-5-15/h1-5,14,16-18,24H,6-13H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM193847
PNG
(US9670210, Example 7 3-[(3-{[(trans-2-Phenylcyclop...)
Show SMILES N#Cc1cccc(CN2CC(CNC3CC3c3ccccc3)C2)c1
Show InChI InChI=1S/C21H23N3/c22-11-16-5-4-6-17(9-16)13-24-14-18(15-24)12-23-21-10-20(21)19-7-2-1-3-8-19/h1-9,18,20-21,23H,10,12-15H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194097
PNG
(US9670210, Example 20 N-(3-Fluorophenyl)-3-{[(tran...)
Show SMILES Fc1cccc(NC(=O)N2CC(CNC3CC3c3ccccc3)C2)c1
Show InChI InChI=1S/C20H22FN3O/c21-16-7-4-8-17(9-16)23-20(25)24-12-14(13-24)11-22-19-10-18(19)15-5-2-1-3-6-15/h1-9,14,18-19,22H,10-13H2,(H,23,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194098
PNG
(US9670210, Example 21 N-(4-Fluorophenyl)-3-{[(tran...)
Show SMILES Fc1ccc(NC(=O)N2CC(CNC3CC3c3ccccc3)C2)cc1
Show InChI InChI=1S/C20H22FN3O/c21-16-6-8-17(9-7-16)23-20(25)24-12-14(13-24)11-22-19-10-18(19)15-4-2-1-3-5-15/h1-9,14,18-19,22H,10-13H2,(H,23,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194103
PNG
(US9670210, Example 22 N-(4-Methoxyphenyl)-3-{[(tra...)
Show SMILES COc1ccc(NC(=O)N2CC(CNC3CC3c3ccccc3)C2)cc1
Show InChI InChI=1S/C21H25N3O2/c1-26-18-9-7-17(8-10-18)23-21(25)24-13-15(14-24)12-22-20-11-19(20)16-5-3-2-4-6-16/h2-10,15,19-20,22H,11-14H2,1H3,(H,23,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194668
PNG
(US9670210, Example 62 4-{[4-(methoxymethyl)-4-({[(...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(Cc2ccc(cc2)C(O)=O)CC1
Show InChI InChI=1S/C25H32N2O3/c1-30-18-25(17-26-23-15-22(23)20-5-3-2-4-6-20)11-13-27(14-12-25)16-19-7-9-21(10-8-19)24(28)29/h2-10,22-23,26H,11-18H2,1H3,(H,28,29)/t22?,23-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194671
PNG
(US9670210, Example 64 1-{[4-({[(1R,2S)-2-(2-fluoro...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2F)CCN(CC2(CCC2)C(O)=O)CC1
Show InChI InChI=1S/C23H33FN2O3/c1-29-16-22(14-25-20-13-18(20)17-5-2-3-6-19(17)24)9-11-26(12-10-22)15-23(21(27)28)7-4-8-23/h2-3,5-6,18,20,25H,4,7-16H2,1H3,(H,27,28)/t18?,20-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194687
PNG
(US9670210, Example 73 1-{[4-[(benzyloxy)methyl]-4-...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(COCc3ccccc3)CC2)CCC1
Show InChI InChI=1S/C29H38N2O3/c32-27(33)29(12-7-13-29)21-31-16-14-28(15-17-31,22-34-19-23-8-3-1-4-9-23)20-30-26-18-25(26)24-10-5-2-6-11-24/h1-6,8-11,25-26,30H,7,12-22H2,(H,32,33)/t25?,26-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194689
PNG
(US9670210, Example 75 1-{[4-[(2-fluorophenoxy)meth...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(COc3ccccc3F)CC2)CC1
Show InChI InChI=1S/C27H33FN2O3/c28-22-8-4-5-9-24(22)33-19-26(17-29-23-16-21(23)20-6-2-1-3-7-20)12-14-30(15-13-26)18-27(10-11-27)25(31)32/h1-9,21,23,29H,10-19H2,(H,31,32)/t21?,23-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194704
PNG
(US9670210, Example 90 1-{[4-[({6-[(methylamino)car...)
Show SMILES CNC(=O)c1ccc(OCC2(CN[C@@H]3CC3c3ccccc3)CCN(CC3(CC3)C(O)=O)CC2)cn1
Show InChI InChI=1S/C28H36N4O4/c1-29-25(33)23-8-7-21(16-30-23)36-19-27(17-31-24-15-22(24)20-5-3-2-4-6-20)11-13-32(14-12-27)18-28(9-10-28)26(34)35/h2-8,16,22,24,31H,9-15,17-19H2,1H3,(H,29,33)(H,34,35)/t22?,24-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM193849
PNG
(US9670210, Example 8 (1-(3-Fluorobenzoyl)-4-{[(tra...)
Show SMILES Fc1cccc(c1)C(=O)N1CCC(CNC2CC2c2ccccc2)(CC#N)CC1
Show InChI InChI=1S/C24H26FN3O/c25-20-8-4-7-19(15-20)23(29)28-13-10-24(9-12-26,11-14-28)17-27-22-16-21(22)18-5-2-1-3-6-18/h1-8,15,21-22,27H,9-11,13-14,16-17H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM193863
PNG
(US9670210, Example 10 (5R)-2-(cis-4-Hydroxycyclohe...)
Show SMILES O[C@H]1CCC(CC1)N1CC[C@@]2(CCCN(C2)C(=O)N2CC(CNC3CC3c3ccccc3)C2)C1=O
Show InChI InChI=1S/C28H40N4O3/c33-23-9-7-22(8-10-23)32-14-12-28(26(32)34)11-4-13-30(19-28)27(35)31-17-20(18-31)16-29-25-15-24(25)21-5-2-1-3-6-21/h1-3,5-6,20,22-25,29,33H,4,7-19H2/t22?,23-,24?,25?,28-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM193883
PNG
(US9670210, Example 16 4-Phenyl-1-[(3-{[(trans-2-ph...)
Show SMILES O=C(N1CC(CNC2CC2c2ccccc2)C1)N1CCC(CC1)(C#N)c1ccccc1
Show InChI InChI=1S/C26H30N4O/c27-19-26(22-9-5-2-6-10-22)11-13-29(14-12-26)25(31)30-17-20(18-30)16-28-24-15-23(24)21-7-3-1-4-8-21/h1-10,20,23-24,28H,11-18H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194116
PNG
(US9670210, Example 27 N-{[1-(3-Methoxybenzoyl)azet...)
Show SMILES COc1cccc(c1)C(=O)N1CC(CNC2CC2c2ccccc2)C1
Show InChI InChI=1S/C21H24N2O2/c1-25-18-9-5-8-17(10-18)21(24)23-13-15(14-23)12-22-20-11-19(20)16-6-3-2-4-7-16/h2-10,15,19-20,22H,11-14H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194128
PNG
(US9670210, Example 30 Trans-2-phenyl-N-[(1-{[4-(tr...)
Show SMILES FC(F)(F)Oc1ccc(cc1)S(=O)(=O)N1CC(CNC2CC2c2ccccc2)C1
Show InChI InChI=1S/C20H21F3N2O3S/c21-20(22,23)28-16-6-8-17(9-7-16)29(26,27)25-12-14(13-25)11-24-19-10-18(19)15-4-2-1-3-5-15/h1-9,14,18-19,24H,10-13H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194129
PNG
(US9670210, Example 31 1-{[4-(4-fluorobenzyl)-4-({[...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(Cc3ccc(F)cc3)CC2)CC1
Show InChI InChI=1S/C27H33FN2O2/c28-22-8-6-20(7-9-22)17-26(18-29-24-16-23(24)21-4-2-1-3-5-21)12-14-30(15-13-26)19-27(10-11-27)25(31)32/h1-9,23-24,29H,10-19H2,(H,31,32)/t23?,24-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194132
PNG
(US9670210, Example 34 1-{[4-(4-fluorobenzyl)-4-({[...)
Show SMILES NC1(CCC1)C(=O)N1CCC(CN[C@@H]2CC2c2ccccc2)(Cc2ccc(F)cc2)CC1
Show InChI InChI=1S/C27H34FN3O/c28-22-9-7-20(8-10-22)18-26(19-30-24-17-23(24)21-5-2-1-3-6-21)13-15-31(16-14-26)25(32)27(29)11-4-12-27/h1-3,5-10,23-24,30H,4,11-19,29H2/t23?,24-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194338
PNG
(US9670210, Example 51 1-{[4-methyl-4-({[(1R,2S)-2-...)
Show SMILES CC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C(=O)C1(N)CCCC1
Show InChI InChI=1S/C22H33N3O/c1-21(16-24-19-15-18(19)17-7-3-2-4-8-17)11-13-25(14-12-21)20(26)22(23)9-5-6-10-22/h2-4,7-8,18-19,24H,5-6,9-16,23H2,1H3/t18?,19-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194381
PNG
(US9670210, Example 52 5-{[4-methyl-4-({[(1R,2S)-2-...)
Show SMILES CC1(CN[C@@H]2CC2c2ccccc2)CCN(Cc2cnc(N)nc2)CC1
Show InChI InChI=1S/C21H29N5/c1-21(15-25-19-11-18(19)17-5-3-2-4-6-17)7-9-26(10-8-21)14-16-12-23-20(22)24-13-16/h2-6,12-13,18-19,25H,7-11,14-15H2,1H3,(H2,22,23,24)/t18?,19-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194640
PNG
(US9670210, Example 57 1-{[4-(3-cyanobenzyl)-4-({[(...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(Cc3cccc(c3)C#N)CC2)CCC1
Show InChI InChI=1S/C29H35N3O2/c30-19-23-7-4-6-22(16-23)18-28(20-31-26-17-25(26)24-8-2-1-3-9-24)12-14-32(15-13-28)21-29(27(33)34)10-5-11-29/h1-4,6-9,16,25-26,31H,5,10-15,17-18,20-21H2,(H,33,34)/t25?,26-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194688
PNG
(US9670210, Example 74 1-{[4-(4-cyano-2-fluorobenzy...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(Cc3ccc(cc3F)C#N)CC2)CC1
Show InChI InChI=1S/C28H32FN3O2/c29-24-14-20(17-30)6-7-22(24)16-27(18-31-25-15-23(25)21-4-2-1-3-5-21)10-12-32(13-11-27)19-28(8-9-28)26(33)34/h1-7,14,23,25,31H,8-13,15-16,18-19H2,(H,33,34)/t23?,25-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194699
PNG
(US9670210, Example 85 1-{[4-[(4-cyanophenoxy)methy...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(COc3ccc(cc3)C#N)CC2)CCC1
Show InChI InChI=1S/C29H35N3O3/c30-18-22-7-9-24(10-8-22)35-21-28(19-31-26-17-25(26)23-5-2-1-3-6-23)13-15-32(16-14-28)20-29(27(33)34)11-4-12-29/h1-3,5-10,25-26,31H,4,11-17,19-21H2,(H,33,34)/t25?,26-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194702
PNG
(US9670210, Example 88 1-{[4-{[(5-fluoropyrimidin-2...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(COc3ncc(F)cn3)CC2)CC1
Show InChI InChI=1S/C25H31FN4O3/c26-19-13-27-23(28-14-19)33-17-24(15-29-21-12-20(21)18-4-2-1-3-5-18)8-10-30(11-9-24)16-25(6-7-25)22(31)32/h1-5,13-14,20-21,29H,6-12,15-17H2,(H,31,32)/t20?,21-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194703
PNG
(US9670210, Example 89 1-{[4-{[(3-fluoropyridin-2-y...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(COc3ncccc3F)CC2)CC1
Show InChI InChI=1S/C26H32FN3O3/c27-21-7-4-12-28-23(21)33-18-25(16-29-22-15-20(22)19-5-2-1-3-6-19)10-13-30(14-11-25)17-26(8-9-26)24(31)32/h1-7,12,20,22,29H,8-11,13-18H2,(H,31,32)/t20?,22-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194709
PNG
(US9670210, Example 95 1-{[4-[(cyclohexyloxy)methyl...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(COC3CCCCC3)CC2)CCC1
Show InChI InChI=1S/C28H42N2O3/c31-26(32)28(12-7-13-28)20-30-16-14-27(15-17-30,21-33-23-10-5-2-6-11-23)19-29-25-18-24(25)22-8-3-1-4-9-22/h1,3-4,8-9,23-25,29H,2,5-7,10-21H2,(H,31,32)/t24?,25-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194714
PNG
(US9670210, Example 100 (trans-4-{[4-(methoxymethyl...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C(=O)[C@H]1CC[C@H](CO)CC1
Show InChI InChI=1S/C25H38N2O3/c1-30-18-25(17-26-23-15-22(23)20-5-3-2-4-6-20)11-13-27(14-12-25)24(29)21-9-7-19(16-28)8-10-21/h2-6,19,21-23,26,28H,7-18H2,1H3/t19-,21-,22?,23-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194715
PNG
(US9670210, Example 101 (cis-4-{[4-(methoxymethyl)-...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C(=O)[C@@H]1CC[C@H](CO)CC1
Show InChI InChI=1S/C25H38N2O3/c1-30-18-25(17-26-23-15-22(23)20-5-3-2-4-6-20)11-13-27(14-12-25)24(29)21-9-7-19(16-28)8-10-21/h2-6,19,21-23,26,28H,7-18H2,1H3/t19-,21+,22?,23-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194730
PNG
(US9670210, Example 116 (1R,2S)N-({4-(methoxymethy...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)S(=O)(=O)c1ccn(C)n1
Show InChI InChI=1S/C21H30N4O3S/c1-24-11-8-20(23-24)29(26,27)25-12-9-21(10-13-25,16-28-2)15-22-19-14-18(19)17-6-4-3-5-7-17/h3-8,11,18-19,22H,9-10,12-16H2,1-2H3/t18?,19-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM193854
PNG
(US9670210, Example 9 (1-(3-Fluorobenzyl)-4-{[(tran...)
Show SMILES Fc1cccc(CN2CCC(CNC3CC3c3ccccc3)(CC#N)CC2)c1
Show InChI InChI=1S/C24H28FN3/c25-21-8-4-5-19(15-21)17-28-13-10-24(9-12-26,11-14-28)18-27-23-16-22(23)20-6-2-1-3-7-20/h1-8,15,22-23,27H,9-11,13-14,16-18H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194246
PNG
(US9670210, Example 46 (1R,2S)N-({4-methyl-1-[(1-m...)
Show SMILES Cn1ccc(n1)C(=O)N1CCC(C)(CN[C@@H]2CC2c2ccccc2)CC1
Show InChI InChI=1S/C21H28N4O/c1-21(15-22-19-14-17(19)16-6-4-3-5-7-16)9-12-25(13-10-21)20(26)18-8-11-24(2)23-18/h3-8,11,17,19,22H,9-10,12-15H2,1-2H3/t17?,19-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194642
PNG
(US9670210, Example 59 3-{[1-(3-methoxybenzyl)-4-({...)
Show SMILES COc1cccc(CN2CCC(CN[C@@H]3CC3c3ccccc3)(Cc3cccc(c3)C(O)=O)CC2)c1
Show InChI InChI=1S/C31H36N2O3/c1-36-27-12-6-8-24(18-27)21-33-15-13-31(14-16-33,20-23-7-5-11-26(17-23)30(34)35)22-32-29-19-28(29)25-9-3-2-4-10-25/h2-12,17-18,28-29,32H,13-16,19-22H2,1H3,(H,34,35)/t28?,29-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194690
PNG
(US9670210, Example 76 1-{[4-[(2-fluorophenoxy)meth...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(COc3ccccc3F)CC2)CCC1
Show InChI InChI=1S/C28H35FN2O3/c29-23-9-4-5-10-25(23)34-20-27(18-30-24-17-22(24)21-7-2-1-3-8-21)13-15-31(16-14-27)19-28(26(32)33)11-6-12-28/h1-5,7-10,22,24,30H,6,11-20H2,(H,32,33)/t22?,24-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194705
PNG
(US9670210, Example 91 1-{[4-[({6-[(methylamino)car...)
Show SMILES CNC(=O)c1cccc(OCC2(CN[C@@H]3CC3c3ccccc3)CCN(CC3(CC3)C(O)=O)CC2)n1
Show InChI InChI=1S/C28H36N4O4/c1-29-25(33)22-8-5-9-24(31-22)36-19-27(17-30-23-16-21(23)20-6-3-2-4-7-20)12-14-32(15-13-27)18-28(10-11-28)26(34)35/h2-9,21,23,30H,10-19H2,1H3,(H,29,33)(H,34,35)/t21?,23-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194720
PNG
(US9670210, Example 106 3-(4-{[4-(methoxymethyl)-4-...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C(=O)c1cnn(CCC#N)c1
Show InChI InChI=1S/C24H31N5O2/c1-31-18-24(17-26-22-14-21(22)19-6-3-2-4-7-19)8-12-28(13-9-24)23(30)20-15-27-29(16-20)11-5-10-25/h2-4,6-7,15-16,21-22,26H,5,8-9,11-14,17-18H2,1H3/t21?,22-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194722
PNG
(US9670210, Example 108 2-(3-{[4-(methoxymethyl)-4-...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C(=O)c1ccn(CCO)n1
Show InChI InChI=1S/C23H32N4O3/c1-30-17-23(16-24-21-15-19(21)18-5-3-2-4-6-18)8-11-26(12-9-23)22(29)20-7-10-27(25-20)13-14-28/h2-7,10,19,21,24,28H,8-9,11-17H2,1H3/t19?,21-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194723
PNG
(US9670210, Example 109 (3R)-1-{[4-(methoxymethyl)-...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C(=O)N1CCC[C@@H](O)C1
Show InChI InChI=1S/C23H35N3O3/c1-29-17-23(16-24-21-14-20(21)18-6-3-2-4-7-18)9-12-25(13-10-23)22(28)26-11-5-8-19(27)15-26/h2-4,6-7,19-21,24,27H,5,8-17H2,1H3/t19-,20?,21-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194727
PNG
(US9670210, Example 113 (1R,2S)N-({4-(methoxymethy...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C(=O)N1CCC(CC1)OC
Show InChI InChI=1S/C24H37N3O3/c1-29-18-24(17-25-22-16-21(22)19-6-4-3-5-7-19)10-14-27(15-11-24)23(28)26-12-8-20(30-2)9-13-26/h3-7,20-22,25H,8-18H2,1-2H3/t21?,22-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194108
PNG
(US9670210, Example 24 N-(2-Methoxyphenyl)-3-{[(tra...)
Show SMILES COc1ccccc1NC(=O)N1CC(CNC2CC2c2ccccc2)C1
Show InChI InChI=1S/C21H25N3O2/c1-26-20-10-6-5-9-18(20)23-21(25)24-13-15(14-24)12-22-19-11-17(19)16-7-3-2-4-8-16/h2-10,15,17,19,22H,11-14H2,1H3,(H,23,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194118
PNG
(US9670210, Example 29 N-{[1-(3-Fluorobenzoyl)azeti...)
Show SMILES Fc1cccc(c1)C(=O)N1CC(CNC2CC2c2ccccc2)C1
Show InChI InChI=1S/C20H21FN2O/c21-17-8-4-7-16(9-17)20(24)23-12-14(13-23)11-22-19-10-18(19)15-5-2-1-3-6-15/h1-9,14,18-19,22H,10-13H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194131
PNG
(US9670210, Example 33 trans-4-{[4-(4-fluorobenzyl)...)
Show SMILES N[C@H]1CC[C@@H](CC1)C(=O)N1CCC(CN[C@@H]2CC2c2ccccc2)(Cc2ccc(F)cc2)CC1
Show InChI InChI=1S/C29H38FN3O/c30-24-10-6-21(7-11-24)19-29(20-32-27-18-26(27)22-4-2-1-3-5-22)14-16-33(17-15-29)28(34)23-8-12-25(31)13-9-23/h1-7,10-11,23,25-27,32H,8-9,12-20,31H2/t23-,25-,26?,27-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194235
PNG
(US9670210, Example 38 (1R,2S)N-[(4-(methoxymethyl...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C(=O)[C@@H]1CCCN1C
Show InChI InChI=1S/C23H35N3O2/c1-25-12-6-9-21(25)22(27)26-13-10-23(11-14-26,17-28-2)16-24-20-15-19(20)18-7-4-3-5-8-18/h3-5,7-8,19-21,24H,6,9-17H2,1-2H3/t19?,20-,21+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194236
PNG
(US9670210, Example 39 (1R,2S)N-({4-(methoxymethyl...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C(=O)c1cn(C)cn1
Show InChI InChI=1S/C22H30N4O2/c1-25-13-20(24-16-25)21(27)26-10-8-22(9-11-26,15-28-2)14-23-19-12-18(19)17-6-4-3-5-7-17/h3-7,13,16,18-19,23H,8-12,14-15H2,1-2H3/t18?,19-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194242
PNG
(US9670210, Example 42 (1R,2S)N-({4-(methoxymethyl...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C(=O)c1ccn(C)n1
Show InChI InChI=1S/C22H30N4O2/c1-25-11-8-19(24-25)21(27)26-12-9-22(10-13-26,16-28-2)15-23-20-14-18(20)17-6-4-3-5-7-17/h3-8,11,18,20,23H,9-10,12-16H2,1-2H3/t18?,20-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194244
PNG
(US9670210, Example 44 1-{[4-methyl-4-({[(1R,2S)-2-...)
Show SMILES CC1(CN[C@@H]2CC2c2ccccc2)CCN(CC2(CC2)C(O)=O)CC1
Show InChI InChI=1S/C21H30N2O2/c1-20(14-22-18-13-17(18)16-5-3-2-4-6-16)9-11-23(12-10-20)15-21(7-8-21)19(24)25/h2-6,17-18,22H,7-15H2,1H3,(H,24,25)/t17?,18-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194255
PNG
(US9670210, Example 48 5-{[4-methyl-4-({[(1R,2S)-2-...)
Show SMILES CC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C(=O)c1cnc(N)nc1
Show InChI InChI=1S/C21H27N5O/c1-21(14-25-18-11-17(18)15-5-3-2-4-6-15)7-9-26(10-8-21)19(27)16-12-23-20(22)24-13-16/h2-6,12-13,17-18,25H,7-11,14H2,1H3,(H2,22,23,24)/t17?,18-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194256
PNG
(US9670210, Example 49 6-{[4-methyl-4-({[(1R,2S)-2-...)
Show SMILES CC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C(=O)c1ccc(N)nn1
Show InChI InChI=1S/C21H27N5O/c1-21(14-23-18-13-16(18)15-5-3-2-4-6-15)9-11-26(12-10-21)20(27)17-7-8-19(22)25-24-17/h2-8,16,18,23H,9-14H2,1H3,(H2,22,25)/t16?,18-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194641
PNG
(US9670210, Example 58 trans-4-{[4-(3-cyanobenzyl)-...)
Show SMILES OC(=O)[C@H]1CC[C@H](CN2CCC(CN[C@@H]3CC3c3ccccc3)(Cc3cccc(c3)C#N)CC2)CC1
Show InChI InChI=1S/C31H39N3O2/c32-20-25-6-4-5-24(17-25)19-31(22-33-29-18-28(29)26-7-2-1-3-8-26)13-15-34(16-14-31)21-23-9-11-27(12-10-23)30(35)36/h1-8,17,23,27-29,33H,9-16,18-19,21-22H2,(H,35,36)/t23-,27-,28?,29-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194692
PNG
(US9670210, Example 78 1-{[4-[(3-fluorophenoxy)meth...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(COc3cccc(F)c3)CC2)CCC1
Show InChI InChI=1S/C28H35FN2O3/c29-22-8-4-9-23(16-22)34-20-27(18-30-25-17-24(25)21-6-2-1-3-7-21)12-14-31(15-13-27)19-28(26(32)33)10-5-11-28/h1-4,6-9,16,24-25,30H,5,10-15,17-20H2,(H,32,33)/t24?,25-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194701
PNG
(US9670210, Example 87 1-{[4-{[(5-fluoropyridin-2-y...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(COc3ccc(F)cn3)CC2)CC1
Show InChI InChI=1S/C26H32FN3O3/c27-20-6-7-23(28-15-20)33-18-25(16-29-22-14-21(22)19-4-2-1-3-5-19)10-12-30(13-11-25)17-26(8-9-26)24(31)32/h1-7,15,21-22,29H,8-14,16-18H2,(H,31,32)/t21?,22-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194697
PNG
(US9670210, Example 83 1-{[4-[(2-cyanophenoxy)methy...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(COc3ccccc3C#N)CC2)CCC1
Show InChI InChI=1S/C29H35N3O3/c30-18-23-9-4-5-10-26(23)35-21-28(19-31-25-17-24(25)22-7-2-1-3-8-22)13-15-32(16-14-28)20-29(27(33)34)11-6-12-29/h1-5,7-10,24-25,31H,6,11-17,19-21H2,(H,33,34)/t24?,25-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194712
PNG
(US9670210, Example 98 1-{[4-(4-methoxybenzyl)-4-({...)
Show SMILES COc1ccc(CC2(CN[C@@H]3CC3c3ccccc3)CCN(CC3(CC3)C(O)=O)CC2)cc1
Show InChI InChI=1S/C28H36N2O3/c1-33-23-9-7-21(8-10-23)18-27(19-29-25-17-24(25)22-5-3-2-4-6-22)13-15-30(16-14-27)20-28(11-12-28)26(31)32/h2-10,24-25,29H,11-20H2,1H3,(H,31,32)/t24?,25-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194713
PNG
(US9670210, Example 99 1-{[4-(4-methoxybenzyl)-4-({...)
Show SMILES COc1ccc(CC2(CN[C@@H]3CC3c3ccccc3)CCN(CC3(CCC3)C(O)=O)CC2)cc1
Show InChI InChI=1S/C29H38N2O3/c1-34-24-10-8-22(9-11-24)19-28(20-30-26-18-25(26)23-6-3-2-4-7-23)14-16-31(17-15-28)21-29(27(32)33)12-5-13-29/h2-4,6-11,25-26,30H,5,12-21H2,1H3,(H,32,33)/t25?,26-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194718
PNG
(US9670210, Example 104 (1R,2S)N-{[1-{[1-(2-methox...)
Show SMILES COCCn1cc(cn1)C(=O)N1CCC(CN[C@@H]2CC2c2ccccc2)(COC)CC1
Show InChI InChI=1S/C24H34N4O3/c1-30-13-12-28-16-20(15-26-28)23(29)27-10-8-24(9-11-27,18-31-2)17-25-22-14-21(22)19-6-4-3-5-7-19/h3-7,15-16,21-22,25H,8-14,17-18H2,1-2H3/t21?,22-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194721
PNG
(US9670210, Example 107 3-(3-{[4-(methoxymethyl)-4-...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C(=O)c1ccn(CCC#N)n1
Show InChI InChI=1S/C24H31N5O2/c1-31-18-24(17-26-22-16-20(22)19-6-3-2-4-7-19)9-14-28(15-10-24)23(30)21-8-13-29(27-21)12-5-11-25/h2-4,6-8,13,20,22,26H,5,9-10,12,14-18H2,1H3/t20?,22-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194724
PNG
(US9670210, Example 110 (3S)-1-{[4-(methoxymethyl)-...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C(=O)N1CCC[C@H](O)C1
Show InChI InChI=1S/C23H35N3O3/c1-29-17-23(16-24-21-14-20(21)18-6-3-2-4-7-18)9-12-25(13-10-23)22(28)26-11-5-8-19(27)15-26/h2-4,6-7,19-21,24,27H,5,8-17H2,1H3/t19-,20?,21+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194725
PNG
(US9670210, Example 111 1-{[4-(methoxymethyl)-4-({[...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C(=O)N1CC(O)C1
Show InChI InChI=1S/C21H31N3O3/c1-27-15-21(14-22-19-11-18(19)16-5-3-2-4-6-16)7-9-23(10-8-21)20(26)24-12-17(25)13-24/h2-6,17-19,22,25H,7-15H2,1H3/t18?,19-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM193833
PNG
(US9670210, Example 1 4-[(3-{[(trans-2-Phenylcyclop...)
Show SMILES OC(=O)c1ccc(CN2CC(CNC3CC3c3ccccc3)C2)cc1
Show InChI InChI=1S/C21H24N2O2/c24-21(25)18-8-6-15(7-9-18)12-23-13-16(14-23)11-22-20-10-19(20)17-4-2-1-3-5-17/h1-9,16,19-20,22H,10-14H2,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM193842
PNG
(US9670210, Example 4 3-({4-[(trans-2-Phenylcyclopr...)
Show SMILES OC(=O)c1cccc(CN2CCC(CC2)NC2CC2c2ccccc2)c1
Show InChI InChI=1S/C22H26N2O2/c25-22(26)18-8-4-5-16(13-18)15-24-11-9-19(10-12-24)23-21-14-20(21)17-6-2-1-3-7-17/h1-8,13,19-21,23H,9-12,14-15H2,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM193839
PNG
(US9670210, Example 3 4-({4-[(trans-2-Phenylcyclopr...)
Show SMILES OC(=O)c1ccc(CN2CCC(CC2)NC2CC2c2ccccc2)cc1
Show InChI InChI=1S/C22H26N2O2/c25-22(26)18-8-6-16(7-9-18)15-24-12-10-19(11-13-24)23-21-14-20(21)17-4-2-1-3-5-17/h1-9,19-21,23H,10-15H2,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%