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Patent code US9670212

Compile Data Set for Download or QSAR
Found 191 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195313
PNG
(US9670212, 36 N,N'-dimethyl-N-{8-methyl-3-[(9H-pur...)
Show SMILES CNCCN(C)c1nc2c(C)cccc2cc1CNc1ncnc2[nH]cnc12
Show InChI InChI=1S/C20H24N8/c1-13-5-4-6-14-9-15(20(27-16(13)14)28(3)8-7-21-2)10-22-18-17-19(24-11-23-17)26-12-25-18/h4-6,9,11-12,21H,7-8,10H2,1-3H3,(H2,22,23,24,25,26)
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n/an/a<50n/an/an/an/an/an/a



Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195788
PNG
(US9670212, 149 N-{3-[(6-amino-9H-purin-9-yl)methyl...)
Show SMILES CNCCN(C)c1nc2c(C)cccc2cc1Cn1cnc2c(N)ncnc12
Show InChI InChI=1S/C20H24N8/c1-13-5-4-6-14-9-15(19(26-16(13)14)27(3)8-7-22-2)10-28-12-25-17-18(21)23-11-24-20(17)28/h4-6,9,11-12,22H,7-8,10H2,1-3H3,(H2,21,23,24)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195361
PNG
(BDBM195393 | US9670212, 48 3-amino-N-[(5-chloro-3-...)
Show SMILES CN(C)Cc1ccccc1-c1cc2c(C)cccc2nc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C24H24N6O.CH4/c1-15-6-5-9-20-18(15)12-19(17-8-4-3-7-16(17)13-26-2)21(30-20)14-29-24(31)22-23(25)28-11-10-27-22;/h3-12,26H,13-14H2,1-2H3,(H2,25,28)(H,29,31);1H4
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195740
PNG
(US9670212, 128 3-amino-N-[(2-{[2-(dimethylamino)et...)
Show SMILES CN(C)CCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C21H27N7O/c1-14-6-5-7-15-12-16(13-25-21(29)18-19(22)24-9-8-23-18)20(26-17(14)15)28(4)11-10-27(2)3/h5-9,12H,10-11,13H2,1-4H3,(H2,22,24)(H,25,29)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195759
PNG
(US9670212, 136 3-amino-N-({2-[{3-[(N,N-dimethylgly...)
Show SMILES CN(C)CC(=O)N(C)CCCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C25H34N8O2/c1-17-8-6-9-18-14-19(15-29-25(35)22-23(26)28-11-10-27-22)24(30-21(17)18)33(5)13-7-12-32(4)20(34)16-31(2)3/h6,8-11,14H,7,12-13,15-16H2,1-5H3,(H2,26,28)(H,29,35)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195793
PNG
(US9670212, 154 N-{[2-(2-chlorophenyl)-8-methylquin...)
Show SMILES Cc1cccc2cc(CNc3ncnc4[nH]cnc34)c(nc12)-c1ccccc1Cl
Show InChI InChI=1S/C22H17ClN6/c1-13-5-4-6-14-9-15(10-24-21-20-22(26-11-25-20)28-12-27-21)19(29-18(13)14)16-7-2-3-8-17(16)23/h2-9,11-12H,10H2,1H3,(H2,24,25,26,27,28)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195302
PNG
(US9670212, 35 N-methyl-N-[2-(methyl{8-methyl-3-[(9...)
Show SMILES CN(CCN(C)c1nc2c(C)cccc2cc1CNc1ncnc2[nH]cnc12)C(=O)Cn1ccnn1
Show InChI InChI=1S/C24H27N11O/c1-16-5-4-6-17-11-18(12-25-22-21-23(27-14-26-21)29-15-28-22)24(31-20(16)17)34(3)10-9-33(2)19(36)13-35-8-7-30-32-35/h4-8,11,14-15H,9-10,12-13H2,1-3H3,(H2,25,26,27,28,29)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195323
PNG
(US9670212, 39 3-amino-N-[(8-methyl-2-{methyl[(1-me...)
Show SMILES CN(CC1CCCCN1C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C24H31N7O/c1-16-7-6-8-17-13-18(14-28-24(32)21-22(25)27-11-10-26-21)23(29-20(16)17)31(3)15-19-9-4-5-12-30(19)2/h6-8,10-11,13,19H,4-5,9,12,14-15H2,1-3H3,(H2,25,27)(H,28,32)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195364
PNG
(US9670212, 49 3-amino-N-{[8-methyl-2-(methyl{2-[me...)
Show SMILES CN(CCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N)C(=O)Cn1cccn1
Show InChI InChI=1S/C25H29N9O2/c1-17-6-4-7-18-14-19(15-29-25(36)22-23(26)28-10-9-27-22)24(31-21(17)18)33(3)13-12-32(2)20(35)16-34-11-5-8-30-34/h4-11,14H,12-13,15-16H2,1-3H3,(H2,26,28)(H,29,36)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195631
PNG
(US9670212, 85 3-amino-N-({2-[{2-[(1H-imidazol-1-yl...)
Show SMILES CN(CCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N)C(=O)Cn1ccnc1
Show InChI InChI=1S/C25H29N9O2/c1-17-5-4-6-18-13-19(14-30-25(36)22-23(26)29-8-7-28-22)24(31-21(17)18)33(3)12-11-32(2)20(35)15-34-10-9-27-16-34/h4-10,13,16H,11-12,14-15H2,1-3H3,(H2,26,29)(H,30,36)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195784
PNG
(US9670212, 145 3-iodo-1-{[3-(2-methylphenyl)quinol...)
Show SMILES Cc1ccccc1-c1cc2ccccc2nc1Cn1nc(I)c2c(N)ncnc12
Show InChI InChI=1S/C22H17IN6/c1-13-6-2-4-8-15(13)16-10-14-7-3-5-9-17(14)27-18(16)11-29-22-19(20(23)28-29)21(24)25-12-26-22/h2-10,12H,11H2,1H3,(H2,24,25,26)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195785
PNG
(US9670212, 146 N-{[8-methyl-2-(4-methyl-1,4-diazep...)
Show SMILES CN1CCCN(CC1)c1nc2c(C)cccc2cc1CNc1ncnc2[nH]cnc12
Show InChI InChI=1S/C22H26N8/c1-15-5-3-6-16-11-17(12-23-20-19-21(25-13-24-19)27-14-26-20)22(28-18(15)16)30-8-4-7-29(2)9-10-30/h3,5-6,11,13-14H,4,7-10,12H2,1-2H3,(H2,23,24,25,26,27)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195823
PNG
(US9670212, 175 3-amino-N-{[5-methyl-3-(2-methylphe...)
Show SMILES Cc1ccccc1-n1c(CNC(=O)c2nccnc2N)nc2cccc(C)c2c1=O
Show InChI InChI=1S/C22H20N6O2/c1-13-6-3-4-9-16(13)28-17(12-26-21(29)19-20(23)25-11-10-24-19)27-15-8-5-7-14(2)18(15)22(28)30/h3-11H,12H2,1-2H3,(H2,23,25)(H,26,29)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195214
PNG
(US9670212, 25 N,8-dimethyl-N-[2-(methyloxy)ethyl]-...)
Show SMILES COCCN(C)c1nc2c(C)cccc2cc1CNc1ncnc2[nH]cnc12
Show InChI InChI=1S/C20H23N7O/c1-13-5-4-6-14-9-15(20(26-16(13)14)27(2)7-8-28-3)10-21-18-17-19(23-11-22-17)25-12-24-18/h4-6,9,11-12H,7-8,10H2,1-3H3,(H2,21,22,23,24,25)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195625
PNG
(US9670212, 83 3-amino-N-{[8-methyl-2-(methyl{2-[me...)
Show SMILES CN(CCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N)Cc1cccnc1
Show InChI InChI=1S/C26H30N8O/c1-18-6-4-8-20-14-21(16-31-26(35)23-24(27)30-11-10-29-23)25(32-22(18)20)34(3)13-12-33(2)17-19-7-5-9-28-15-19/h4-11,14-15H,12-13,16-17H2,1-3H3,(H2,27,30)(H,31,35)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195231
PNG
(US9670212, 28 N-{2-[{3-[(6-amino-9H-purin-9-yl)met...)
Show SMILES CN(CCN(C)c1nc2c(C)cccc2cc1Cn1cnc2c(N)ncnc12)C(=O)Cn1cccn1
Show InChI InChI=1S/C25H28N10O/c1-17-6-4-7-18-12-19(13-34-16-29-22-23(26)27-15-28-25(22)34)24(31-21(17)18)33(3)11-10-32(2)20(36)14-35-9-5-8-30-35/h4-9,12,15-16H,10-11,13-14H2,1-3H3,(H2,26,27,28)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195254
PNG
(US9670212, 31 3-amino-N-[(8-methyl-2-{methyl[(1-me...)
Show SMILES CN(CC1CCN(C)CC1)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C24H31N7O/c1-16-5-4-6-18-13-19(14-28-24(32)21-22(25)27-10-9-26-21)23(29-20(16)18)31(3)15-17-7-11-30(2)12-8-17/h4-6,9-10,13,17H,7-8,11-12,14-15H2,1-3H3,(H2,25,27)(H,28,32)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195664
PNG
(US9670212, 100 3-amino-N-{[8-methyl-2-(methyl{2-[m...)
Show SMILES CN(CCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N)C(=O)Cn1ccnn1
Show InChI InChI=1S/C24H28N10O2/c1-16-5-4-6-17-13-18(14-28-24(36)21-22(25)27-8-7-26-21)23(30-20(16)17)33(3)12-11-32(2)19(35)15-34-10-9-29-31-34/h4-10,13H,11-12,14-15H2,1-3H3,(H2,25,27)(H,28,36)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195083
PNG
(US9670212, 4 3-[(6-amino-9H-purin-9-yl)methyl]-N,8...)
Show SMILES CN(CC1CCN(C)CC1)c1nc2c(C)cccc2cc1Cn1cnc2c(N)ncnc12
Show InChI InChI=1S/C24H30N8/c1-16-5-4-6-18-11-19(13-32-15-28-21-22(25)26-14-27-24(21)32)23(29-20(16)18)31(3)12-17-7-9-30(2)10-8-17/h4-6,11,14-15,17H,7-10,12-13H2,1-3H3,(H2,25,26,27)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195314
PNG
(US9670212, 37 N-[(8-methyl-2-piperazin-1-ylquinoli...)
Show SMILES Cc1cccc2cc(CNc3ncnc4[nH]cnc34)c(nc12)N1CCNCC1
Show InChI InChI=1S/C20H22N8/c1-13-3-2-4-14-9-15(20(27-16(13)14)28-7-5-21-6-8-28)10-22-18-17-19(24-11-23-17)26-12-25-18/h2-4,9,11-12,21H,5-8,10H2,1H3,(H2,22,23,24,25,26)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195452
PNG
(US9670212, 67 3-amino-N-{[8-methyl-2-(methyl{2-[me...)
Show SMILES CCCN1CCC[C@@H]1C(=O)N(C)CCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C28H38N8O2/c1-5-13-36-14-7-10-22(36)28(38)35(4)16-15-34(3)26-21(17-20-9-6-8-19(2)23(20)33-26)18-32-27(37)24-25(29)31-12-11-30-24/h6,8-9,11-12,17,22H,5,7,10,13-16,18H2,1-4H3,(H2,29,31)(H,32,37)/t22-/m1/s1
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195636
PNG
(US9670212, 89 3-amino-N-({2-[(2-{[2-(dimethylamino...)
Show SMILES CN(CCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N)CC(=O)N(C)C
Show InChI InChI=1S/C24H32N8O2/c1-16-7-6-8-17-13-18(14-28-24(34)21-22(25)27-10-9-26-21)23(29-20(16)17)32(5)12-11-31(4)15-19(33)30(2)3/h6-10,13H,11-12,14-15H2,1-5H3,(H2,25,27)(H,28,34)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195755
PNG
(US9670212, 134 3-iodo-1-{[8-methyl-2-(2-methylphen...)
Show SMILES Cc1ccccc1-c1nc2c(C)cccc2cc1Cn1nc(I)c2c(N)ncnc12
Show InChI InChI=1S/C23H19IN6/c1-13-6-3-4-9-17(13)20-16(10-15-8-5-7-14(2)19(15)28-20)11-30-23-18(21(24)29-30)22(25)26-12-27-23/h3-10,12H,11H2,1-2H3,(H2,25,26,27)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195165
PNG
(US9670212, 12 N-{[8-methyl-2-(octahydro-2H-pyrido[...)
Show SMILES Cc1cccc2cc(CNc3ncnc4[nH]cnc34)c(nc12)N1CCN2CCCCC2C1
Show InChI InChI=1S/C24H28N8/c1-16-5-4-6-17-11-18(12-25-22-21-23(27-14-26-21)29-15-28-22)24(30-20(16)17)32-10-9-31-8-3-2-7-19(31)13-32/h4-6,11,14-15,19H,2-3,7-10,12-13H2,1H3,(H2,25,26,27,28,29)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195341
PNG
(US9670212, 43 3-amino-N-({2-[(2-{[(3,5-dimethyl-1H...)
Show SMILES CN(CCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N)C(=O)Cn1nc(C)nc1C
Show InChI InChI=1S/C26H32N10O2/c1-16-7-6-8-19-13-20(14-30-26(38)23-24(27)29-10-9-28-23)25(32-22(16)19)35(5)12-11-34(4)21(37)15-36-18(3)31-17(2)33-36/h6-10,13H,11-12,14-15H2,1-5H3,(H2,27,29)(H,30,38)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195468
PNG
(US9670212, 73 3-amino-N-({8-methyl-2-[methyl(2-{me...)
Show SMILES CC(C)N1CCC[C@@H]1C(=O)N(C)CCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C28H38N8O2/c1-18(2)36-13-7-10-22(36)28(38)35(5)15-14-34(4)26-21(16-20-9-6-8-19(3)23(20)33-26)17-32-27(37)24-25(29)31-12-11-30-24/h6,8-9,11-12,16,18,22H,7,10,13-15,17H2,1-5H3,(H2,29,31)(H,32,37)/t22-/m1/s1
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195632
PNG
(US9670212, 86 3-amino-N-({8-methyl-2-[methyl(2-{me...)
Show SMILES CN(CCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N)C(=O)Cn1ccnc1C
Show InChI InChI=1S/C26H31N9O2/c1-17-6-5-7-19-14-20(15-31-26(37)23-24(27)30-9-8-29-23)25(32-22(17)19)34(4)13-12-33(3)21(36)16-35-11-10-28-18(35)2/h5-11,14H,12-13,15-16H2,1-4H3,(H2,27,30)(H,31,37)
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Exelixis, Inc.

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Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195729
PNG
(US9670212, 119 3-iodo-1-{[5-methyl-3-(2-methylphen...)
Show SMILES Cc1ccccc1-c1cc2c(C)cccc2nc1Cn1nc(I)c2c(N)ncnc12
Show InChI InChI=1S/C23H19IN6/c1-13-6-3-4-8-15(13)17-10-16-14(2)7-5-9-18(16)28-19(17)11-30-23-20(21(24)29-30)22(25)26-12-27-23/h3-10,12H,11H2,1-2H3,(H2,25,26,27)
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Exelixis, Inc.

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Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195767
PNG
(US9670212, 143 N-{[2-(4-acetylpiperazin-1-yl)-8-me...)
Show SMILES CC(=O)N1CCN(CC1)c1nc2c(C)cccc2cc1CNc1ncnc2[nH]cnc12
Show InChI InChI=1S/C22H24N8O/c1-14-4-3-5-16-10-17(11-23-20-19-21(25-12-24-19)27-13-26-20)22(28-18(14)16)30-8-6-29(7-9-30)15(2)31/h3-5,10,12-13H,6-9,11H2,1-2H3,(H2,23,24,25,26,27)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM50004540
PNG
(CHEMBL2216869 | US9670212, 2 3-[(6-amino-9H-purin-...)
Show SMILES CN(CC1CCCN1C)c1nc2c(C)cccc2cc1Cn1cnc2c(N)ncnc12
Show InChI InChI=1S/C23H28N8/c1-15-6-4-7-16-10-17(11-31-14-27-20-21(24)25-13-26-23(20)31)22(28-19(15)16)30(3)12-18-8-5-9-29(18)2/h4,6-7,10,13-14,18H,5,8-9,11-12H2,1-3H3,(H2,24,25,26)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195256
PNG
(US9670212, 32 N,8-dimethyl-N-[(1-methylpiperidin-3...)
Show SMILES CN(CC1CCCN(C)C1)c1nc2c(C)cccc2cc1CNc1ncnc2[nH]cnc12
Show InChI InChI=1S/C24H30N8/c1-16-6-4-8-18-10-19(11-25-22-21-23(27-14-26-21)29-15-28-22)24(30-20(16)18)32(3)13-17-7-5-9-31(2)12-17/h4,6,8,10,14-15,17H,5,7,9,11-13H2,1-3H3,(H2,25,26,27,28,29)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195315
PNG
(US9670212, 38 N,8-dimethyl-N-[(1-methylpiperidin-2...)
Show SMILES CN(CC1CCCCN1C)c1nc2c(C)cccc2cc1CNc1ncnc2[nH]cnc12
Show InChI InChI=1S/C24H30N8/c1-16-7-6-8-17-11-18(12-25-22-21-23(27-14-26-21)29-15-28-22)24(30-20(16)17)32(3)13-19-9-4-5-10-31(19)2/h6-8,11,14-15,19H,4-5,9-10,12-13H2,1-3H3,(H2,25,26,27,28,29)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195361
PNG
(BDBM195393 | US9670212, 48 3-amino-N-[(5-chloro-3-...)
Show SMILES CN(C)Cc1ccccc1-c1cc2c(C)cccc2nc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C24H24N6O.CH4/c1-15-6-5-9-20-18(15)12-19(17-8-4-3-7-16(17)13-26-2)21(30-20)14-29-24(31)22-23(25)28-11-10-27-22;/h3-12,26H,13-14H2,1-2H3,(H2,25,28)(H,29,31);1H4
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195791
PNG
(US9670212, 152 N-{1-[2-(2-chlorophenyl)-8-methylqu...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1cc2cccc(C)c2nc1-c1ccccc1Cl
Show InChI InChI=1S/C23H19ClN6/c1-13-6-5-7-15-10-17(20(30-19(13)15)16-8-3-4-9-18(16)24)14(2)29-23-21-22(26-11-25-21)27-12-28-23/h3-12,14H,1-2H3,(H2,25,26,27,28,29)
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Exelixis, Inc.

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Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195082
PNG
(US9670212, 3 3-[(6-amino-9H-purin-9-yl)methyl]-N,8...)
Show SMILES CN(CC1CCCCN1C)c1nc2c(C)cccc2cc1Cn1cnc2c(N)ncnc12
Show InChI InChI=1S/C24H30N8/c1-16-7-6-8-17-11-18(12-32-15-28-21-22(25)26-14-27-24(21)32)23(29-20(16)17)31(3)13-19-9-4-5-10-30(19)2/h6-8,11,14-15,19H,4-5,9-10,12-13H2,1-3H3,(H2,25,26,27)
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Exelixis, Inc.

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Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195234
PNG
(US9670212, 30 3-amino-N-[(8-methyl-2-{methyl[(1-me...)
Show SMILES CN(CC1CCCN(C)C1)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C24H31N7O/c1-16-6-4-8-18-12-19(13-28-24(32)21-22(25)27-10-9-26-21)23(29-20(16)18)31(3)15-17-7-5-11-30(2)14-17/h4,6,8-10,12,17H,5,7,11,13-15H2,1-3H3,(H2,25,27)(H,28,32)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195271
PNG
(US9670212, 33 N,8-dimethyl-N-[(1-methylpiperidin-4...)
Show SMILES CN(CC1CCN(C)CC1)c1nc2c(C)cccc2cc1CNc1ncnc2[nH]cnc12
Show InChI InChI=1S/C24H30N8/c1-16-5-4-6-18-11-19(12-25-22-21-23(27-14-26-21)29-15-28-22)24(30-20(16)18)32(3)13-17-7-9-31(2)10-8-17/h4-6,11,14-15,17H,7-10,12-13H2,1-3H3,(H2,25,26,27,28,29)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195289
PNG
(US9670212, 34 N-{2-[{3-[(6-amino-9H-purin-9-yl)met...)
Show SMILES CN(CCN(C)c1nc2c(C)cccc2cc1Cn1cnc2c(N)ncnc12)C(=O)Cn1ccnn1
Show InChI InChI=1S/C24H27N11O/c1-16-5-4-6-17-11-18(12-34-15-28-21-22(25)26-14-27-24(21)34)23(30-20(16)17)33(3)10-9-32(2)19(36)13-35-8-7-29-31-35/h4-8,11,14-15H,9-10,12-13H2,1-3H3,(H2,25,26,27)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195724
PNG
(US9670212, 117 3-iodo-1-{1-[3-(2-methylphenyl)quin...)
Show SMILES CC(c1nc2ccccc2cc1-c1ccccc1C)n1nc(I)c2c(N)ncnc12
Show InChI InChI=1S/C23H19IN6/c1-13-7-3-5-9-16(13)17-11-15-8-4-6-10-18(15)28-20(17)14(2)30-23-19(21(24)29-30)22(25)26-12-27-23/h3-12,14H,1-2H3,(H2,25,26,27)
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Exelixis, Inc.

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Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195783
PNG
(US9670212, 144 N-{[2-(4-ethylpiperazin-1-yl)-8-met...)
Show SMILES CCN1CCN(CC1)c1nc2c(C)cccc2cc1CNc1ncnc2[nH]cnc12
Show InChI InChI=1S/C22H26N8/c1-3-29-7-9-30(10-8-29)22-17(11-16-6-4-5-15(2)18(16)28-22)12-23-20-19-21(25-13-24-19)27-14-26-20/h4-6,11,13-14H,3,7-10,12H2,1-2H3,(H2,23,24,25,26,27)
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US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195333
PNG
(US9670212, 42 3-amino-N-{[8-methyl-2-(methyl{2-[me...)
Show SMILES CN(CCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N)C(=O)Cn1cnnn1
Show InChI InChI=1S/C23H27N11O2/c1-15-5-4-6-16-11-17(12-27-23(36)20-21(24)26-8-7-25-20)22(29-19(15)16)33(3)10-9-32(2)18(35)13-34-14-28-30-31-34/h4-8,11,14H,9-10,12-13H2,1-3H3,(H2,24,26)(H,27,36)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195387
PNG
(US9670212, 51 3-amino-N-{[8-methyl-2-(methyl{2-[(1...)
Show SMILES CN(CCNC(=O)Cn1ccnn1)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C23H26N10O2/c1-15-4-3-5-16-12-17(13-28-23(35)20-21(24)27-7-6-26-20)22(30-19(15)16)32(2)10-8-25-18(34)14-33-11-9-29-31-33/h3-7,9,11-12H,8,10,13-14H2,1-2H3,(H2,24,27)(H,25,34)(H,28,35)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195854
PNG
(US9670212, 189 9-{[8-methyl-2-(2-methylphenyl)quin...)
Show SMILES Cc1ccccc1-c1nc2c(C)cccc2cc1Cn1cnc2c(N)ncnc12
Show InChI InChI=1S/C23H20N6/c1-14-6-3-4-9-18(14)20-17(10-16-8-5-7-15(2)19(16)28-20)11-29-13-27-21-22(24)25-12-26-23(21)29/h3-10,12-13H,11H2,1-2H3,(H2,24,25,26)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195846
PNG
(US9670212, 181 9-{[2-(2,5-dimethylphenyl)-8-methyl...)
Show SMILES C.Cc1cccc(c1)-c1nc2c(C)cccc2cc1Cn1cnc2c(N)ncnc12
Show InChI InChI=1S/C23H20N6.CH4/c1-14-5-3-7-16(9-14)20-18(10-17-8-4-6-15(2)19(17)28-20)11-29-13-27-21-22(24)25-12-26-23(21)29;/h3-10,12-13H,11H2,1-2H3,(H2,24,25,26);1H4
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195819
PNG
(US9670212, 171 9-[(8-methyl-2-pyrrolidin-1-ylquino...)
Show SMILES Cc1cccc2cc(Cn3cnc4c(N)ncnc34)c(nc12)N1CCCC1
Show InChI InChI=1S/C20H21N7/c1-13-5-4-6-14-9-15(19(25-16(13)14)26-7-2-3-8-26)10-27-12-24-17-18(21)22-11-23-20(17)27/h4-6,9,11-12H,2-3,7-8,10H2,1H3,(H2,21,22,23)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195693
PNG
(US9670212, 110 3-amino-N-({8-methyl-2-[methyl(2-{m...)
Show SMILES CN(CCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N)C(=O)c1cncn1C
Show InChI InChI=1S/C25H29N9O2/c1-16-6-5-7-17-12-18(13-30-24(35)21-22(26)29-9-8-28-21)23(31-20(16)17)32(2)10-11-33(3)25(36)19-14-27-15-34(19)4/h5-9,12,14-15H,10-11,13H2,1-4H3,(H2,26,29)(H,30,35)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195448
PNG
(US9670212, 63 3-amino-N-[(8-methyl-2-{4-[(1-methyl...)
Show SMILES Cc1cccc2cc(CNC(=O)c3nccnc3N)c(nc12)N1CCCN(Cc2cncn2C)CC1
Show InChI InChI=1S/C26H31N9O/c1-18-5-3-6-19-13-20(14-31-26(36)23-24(27)30-8-7-29-23)25(32-22(18)19)35-10-4-9-34(11-12-35)16-21-15-28-17-33(21)2/h3,5-8,13,15,17H,4,9-12,14,16H2,1-2H3,(H2,27,30)(H,31,36)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195847
PNG
(US9670212, 182 9-({8-methyl-2-[2-(trifluoromethyl)...)
Show SMILES Cc1cccc2cc(Cn3cnc4c(N)ncnc34)c(nc12)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C23H17F3N6/c1-13-5-4-6-14-9-15(10-32-12-30-20-21(27)28-11-29-22(20)32)19(31-18(13)14)16-7-2-3-8-17(16)23(24,25)26/h2-9,11-12H,10H2,1H3,(H2,27,28,29)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195711
PNG
(US9670212, 114 3-amino-N-({2-[{2-[(N,N-dimethylgly...)
Show SMILES CN(C)CC(=O)N(C)CCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C24H32N8O2/c1-16-7-6-8-17-13-18(14-28-24(34)21-22(25)27-10-9-26-21)23(29-20(16)17)32(5)12-11-31(4)19(33)15-30(2)3/h6-10,13H,11-12,14-15H2,1-5H3,(H2,25,27)(H,28,34)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195663
PNG
(US9670212, 99 3-amino-N-({8-methyl-2-[methyl(1-met...)
Show SMILES CN(C1CCN(C)CC1)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C23H29N7O/c1-15-5-4-6-16-13-17(14-27-23(31)20-21(24)26-10-9-25-20)22(28-19(15)16)30(3)18-7-11-29(2)12-8-18/h4-6,9-10,13,18H,7-8,11-12,14H2,1-3H3,(H2,24,26)(H,27,31)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195639
PNG
(US9670212, 92 3-amino-N-[(3-{2-[(dimethylamino)met...)
Show SMILES CN(C)Cc1ccccc1-c1cc2ccccc2nc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C24H24N6O/c1-30(2)15-17-8-3-5-9-18(17)19-13-16-7-4-6-10-20(16)29-21(19)14-28-24(31)22-23(25)27-12-11-26-22/h3-13H,14-15H2,1-2H3,(H2,25,27)(H,28,31)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195633
PNG
(US9670212, 87 3-amino-N-({8-methyl-2-[methyl(pyrid...)
Show SMILES CN(Cc1cccnc1)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C23H23N7O/c1-15-5-3-7-17-11-18(13-28-23(31)20-21(24)27-10-9-26-20)22(29-19(15)17)30(2)14-16-6-4-8-25-12-16/h3-12H,13-14H2,1-2H3,(H2,24,27)(H,28,31)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195444
PNG
(US9670212, 59 3-amino-N-({3-[2-(piperidin-1-ylmeth...)
Show SMILES Nc1nccnc1C(=O)NCc1nc2ccccc2cc1-c1ccccc1CN1CCCCC1
Show InChI InChI=1S/C27H28N6O/c28-26-25(29-12-13-30-26)27(34)31-17-24-22(16-19-8-3-5-11-23(19)32-24)21-10-4-2-9-20(21)18-33-14-6-1-7-15-33/h2-5,8-13,16H,1,6-7,14-15,17-18H2,(H2,28,30)(H,31,34)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195820
PNG
(US9670212, 172 9-[(8-methyl-2-piperazin-1-ylquinol...)
Show SMILES Cc1cccc2cc(Cn3cnc4c(N)ncnc34)c(nc12)N1CCNCC1
Show InChI InChI=1S/C20H22N8/c1-13-3-2-4-14-9-15(19(26-16(13)14)27-7-5-22-6-8-27)10-28-12-25-17-18(21)23-11-24-20(17)28/h2-4,9,11-12,22H,5-8,10H2,1H3,(H2,21,23,24)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195787
PNG
(US9670212, 148 3-amino-N-{[2-(2-chlorophenyl)-8-me...)
Show SMILES Cc1cccc2cc(CNC(=O)c3nccnc3N)c(nc12)-c1ccccc1Cl
Show InChI InChI=1S/C22H18ClN5O/c1-13-5-4-6-14-11-15(12-27-22(29)20-21(24)26-10-9-25-20)19(28-18(13)14)16-7-2-3-8-17(16)23/h2-11H,12H2,1H3,(H2,24,26)(H,27,29)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195718
PNG
(US9670212, 115 3-amino-N-({2-[{2-[glycyl(methyl)am...)
Show SMILES CN(CCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N)C(=O)CN
Show InChI InChI=1S/C22H28N8O2/c1-14-5-4-6-15-11-16(13-27-22(32)19-20(24)26-8-7-25-19)21(28-18(14)15)30(3)10-9-29(2)17(31)12-23/h4-8,11H,9-10,12-13,23H2,1-3H3,(H2,24,26)(H,27,32)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195626
PNG
(US9670212, 84 3-amino-N-({2-[{2-[(cyanomethyl)(met...)
Show SMILES CN(CCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N)CC#N
Show InChI InChI=1S/C22H26N8O/c1-15-5-4-6-16-13-17(14-27-22(31)19-20(24)26-9-8-25-19)21(28-18(15)16)30(3)12-11-29(2)10-7-23/h4-6,8-9,13H,10-12,14H2,1-3H3,(H2,24,26)(H,27,31)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195818
PNG
(US9670212, 170 9-{[8-methyl-2-(2-methylpyrrolidin-...)
Show SMILES CC1CCCN1c1nc2c(C)cccc2cc1Cn1cnc2c(N)ncnc12
Show InChI InChI=1S/C21H23N7/c1-13-5-3-7-15-9-16(20(26-17(13)15)28-8-4-6-14(28)2)10-27-12-25-18-19(22)23-11-24-21(18)27/h3,5,7,9,11-12,14H,4,6,8,10H2,1-2H3,(H2,22,23,24)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195665
PNG
(US9670212, 101 3-amino-N-{[8-methyl-2-(methyl{2-[m...)
Show SMILES CN(CCN(C)S(C)(=O)=O)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C21H27N7O3S/c1-14-6-5-7-15-12-16(13-25-21(29)18-19(22)24-9-8-23-18)20(26-17(14)15)27(2)10-11-28(3)32(4,30)31/h5-9,12H,10-11,13H2,1-4H3,(H2,22,24)(H,25,29)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195666
PNG
(US9670212, 102 3-amino-N-{[8-methyl-2-(methyl{2-[m...)
Show SMILES CN(CCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N)C(=O)[C@H]1CCCN1
Show InChI InChI=1S/C25H32N8O2/c1-16-6-4-7-17-14-18(15-30-24(34)21-22(26)29-11-10-28-21)23(31-20(16)17)32(2)12-13-33(3)25(35)19-8-5-9-27-19/h4,6-7,10-11,14,19,27H,5,8-9,12-13,15H2,1-3H3,(H2,26,29)(H,30,34)/t19-/m1/s1
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195852
PNG
(US9670212, 187 9-{[2-(2-chlorophenyl)-8-methylquin...)
Show SMILES Cc1cccc2cc(Cn3cnc4c(N)ncnc34)c(nc12)-c1ccccc1Cl
Show InChI InChI=1S/C22H17ClN6/c1-13-5-4-6-14-9-15(10-29-12-27-20-21(24)25-11-26-22(20)29)19(28-18(13)14)16-7-2-3-8-17(16)23/h2-9,11-12H,10H2,1H3,(H2,24,25,26)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195843
PNG
(US9670212, 178 7-{[3-(2-methylphenyl)quinolin-2-yl...)
Show SMILES Cc1ccccc1-c1cc2ccccc2nc1Cn1cnc2ncnc(N)c12
Show InChI InChI=1S/C22H18N6/c1-14-6-2-4-8-16(14)17-10-15-7-3-5-9-18(15)27-19(17)11-28-13-26-22-20(28)21(23)24-12-25-22/h2-10,12-13H,11H2,1H3,(H2,23,24,25)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195842
PNG
(US9670212, 177 9-[(8-methyl-2-morpholin-4-ylquinol...)
Show SMILES Cc1cccc2cc(Cn3cnc4c(N)ncnc34)c(nc12)N1CCOCC1
Show InChI InChI=1S/C20H21N7O/c1-13-3-2-4-14-9-15(19(25-16(13)14)26-5-7-28-8-6-26)10-27-12-24-17-18(21)22-11-23-20(17)27/h2-4,9,11-12H,5-8,10H2,1H3,(H2,21,22,23)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195491
PNG
(US9670212, 77 3-amino-N-{[8-methyl-2-(methyl{2-[me...)
Show SMILES CN(CCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N)CC(=O)N1CCOCC1
Show InChI InChI=1S/C26H34N8O3/c1-18-5-4-6-19-15-20(16-30-26(36)23-24(27)29-8-7-28-23)25(31-22(18)19)33(3)10-9-32(2)17-21(35)34-11-13-37-14-12-34/h4-8,15H,9-14,16-17H2,1-3H3,(H2,27,29)(H,30,36)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195662
PNG
(US9670212, 98 3-amino-N-({8-methyl-2-[methyl(1-met...)
Show SMILES CN(C1CCN(C)C1)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C22H27N7O/c1-14-5-4-6-15-11-16(12-26-22(30)19-20(23)25-9-8-24-19)21(27-18(14)15)29(3)17-7-10-28(2)13-17/h4-6,8-9,11,17H,7,10,12-13H2,1-3H3,(H2,23,25)(H,26,30)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195691
PNG
(US9670212, 109 3-amino-N-{[8-methyl-2-(methyl{2-[m...)
Show SMILES CN(CCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N)C(=O)CN1CCCC1
Show InChI InChI=1S/C26H34N8O2/c1-18-7-6-8-19-15-20(16-30-26(36)23-24(27)29-10-9-28-23)25(31-22(18)19)33(3)14-13-32(2)21(35)17-34-11-4-5-12-34/h6-10,15H,4-5,11-14,16-17H2,1-3H3,(H2,27,29)(H,30,36)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195745
PNG
(US9670212, 133 3-amino-N-[(8-methyl-2-{methyl[3-(m...)
Show SMILES CNCCCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C21H27N7O/c1-14-6-4-7-15-12-16(13-26-21(29)18-19(22)25-10-9-24-18)20(27-17(14)15)28(3)11-5-8-23-2/h4,6-7,9-10,12,23H,5,8,11,13H2,1-3H3,(H2,22,25)(H,26,29)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195758
PNG
(US9670212, 135 3-iodo-N-{[8-methyl-2-(2-methylphen...)
Show SMILES C.Cc1cccc2cc(CNc3ncnc4[nH]nc(I)c34)c(nc12)-c1ccccc1
Show InChI InChI=1S/C22H17IN6.CH4/c1-13-6-5-9-15-10-16(19(27-18(13)15)14-7-3-2-4-8-14)11-24-21-17-20(23)28-29-22(17)26-12-25-21;/h2-10,12H,11H2,1H3,(H2,24,25,26,28,29);1H4
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195813
PNG
(US9670212, 166 9-{[2-(4-acetylpiperazin-1-yl)-8-me...)
Show SMILES CC(=O)N1CCN(CC1)c1nc2c(C)cccc2cc1Cn1cnc2c(N)ncnc12
Show InChI InChI=1S/C22H24N8O/c1-14-4-3-5-16-10-17(11-30-13-26-19-20(23)24-12-25-22(19)30)21(27-18(14)16)29-8-6-28(7-9-29)15(2)31/h3-5,10,12-13H,6-9,11H2,1-2H3,(H2,23,24,25)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195215
PNG
(US9670212, 26 N-butyl-N,8-dimethyl-3-[(9H-purin-6-...)
Show SMILES CCCCN(C)c1nc2c(C)cccc2cc1CNc1ncnc2[nH]cnc12
Show InChI InChI=1S/C21H25N7/c1-4-5-9-28(3)21-16(10-15-8-6-7-14(2)17(15)27-21)11-22-19-18-20(24-12-23-18)26-13-25-19/h6-8,10,12-13H,4-5,9,11H2,1-3H3,(H2,22,23,24,25,26)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195228
PNG
(US9670212, 27 N-[(8-methyl-2-piperidin-1-ylquinoli...)
Show SMILES Cc1cccc2cc(CNc3ncnc4[nH]cnc34)c(nc12)N1CCCCC1
Show InChI InChI=1S/C21H23N7/c1-14-6-5-7-15-10-16(21(27-17(14)15)28-8-3-2-4-9-28)11-22-19-18-20(24-12-23-18)26-13-25-19/h5-7,10,12-13H,2-4,8-9,11H2,1H3,(H2,22,23,24,25,26)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195453
PNG
(US9670212, 68 3-amino-N-{[8-methyl-2-(methyl{2-[me...)
Show SMILES CN(CCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N)Cc1ccccn1
Show InChI InChI=1S/C26H30N8O/c1-18-7-6-8-19-15-20(16-31-26(35)23-24(27)30-12-11-29-23)25(32-22(18)19)34(3)14-13-33(2)17-21-9-4-5-10-28-21/h4-12,15H,13-14,16-17H2,1-3H3,(H2,27,30)(H,31,35)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195587
PNG
(US9670212, 79 3-amino-N-{[8-methyl-2-(methyl{2-[me...)
Show SMILES CN(CCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N)C(=O)c1ccncc1
Show InChI InChI=1S/C26H28N8O2/c1-17-5-4-6-19-15-20(16-31-25(35)22-23(27)30-12-11-29-22)24(32-21(17)19)33(2)13-14-34(3)26(36)18-7-9-28-10-8-18/h4-12,15H,13-14,16H2,1-3H3,(H2,27,30)(H,31,35)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195723
PNG
(US9670212, 116 3-amino-N-{[8-methyl-2-(methyl{2-[m...)
Show SMILES CNCC(=O)N(C)CCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C23H30N8O2/c1-15-6-5-7-16-12-17(13-28-23(33)20-21(24)27-9-8-26-20)22(29-19(15)16)31(4)11-10-30(3)18(32)14-25-2/h5-9,12,25H,10-11,13-14H2,1-4H3,(H2,24,27)(H,28,33)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195794
PNG
(US9670212, 155 N-{[3-(2-methylphenyl)quinolin-2-yl...)
Show SMILES Cc1ccccc1-c1cc2ccccc2nc1CNc1ncnc2[nH]cnc12
Show InChI InChI=1S/C22H18N6/c1-14-6-2-4-8-16(14)17-10-15-7-3-5-9-18(15)28-19(17)11-23-21-20-22(25-12-24-20)27-13-26-21/h2-10,12-13H,11H2,1H3,(H2,23,24,25,26,27)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195821
PNG
(US9670212, 173 9-{[8-methyl-2-(4-methylpiperazin-1...)
Show SMILES CN1CCN(CC1)c1nc2c(C)cccc2cc1Cn1cnc2c(N)ncnc12
Show InChI InChI=1S/C21H24N8/c1-14-4-3-5-15-10-16(11-29-13-25-18-19(22)23-12-24-21(18)29)20(26-17(14)15)28-8-6-27(2)7-9-28/h3-5,10,12-13H,6-9,11H2,1-2H3,(H2,22,23,24)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195853
PNG
(US9670212, 188 8-methyl-2-(2-methylphenyl)-3-[(9H-...)
Show SMILES Cc1ccccc1-c1nc2c(C)cccc2cc1CSc1ncnc2[nH]cnc12
Show InChI InChI=1S/C23H19N5S/c1-14-6-3-4-9-18(14)20-17(10-16-8-5-7-15(2)19(16)28-20)11-29-23-21-22(25-12-24-21)26-13-27-23/h3-10,12-13H,11H2,1-2H3,(H,24,25,26,27)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195080
PNG
(US9670212, 1 N,8-dimethyl-N-[(1-methylpiperidin-4-...)
Show SMILES CN(CC1CCN(C)CC1)c1nc2c(C)cccc2cc1CSc1ncnc2[nH]cnc12
Show InChI InChI=1S/C24H29N7S/c1-16-5-4-6-18-11-19(13-32-24-21-22(26-14-25-21)27-15-28-24)23(29-20(16)18)31(3)12-17-7-9-30(2)10-8-17/h4-6,11,14-15,17H,7-10,12-13H2,1-3H3,(H,25,26,27,28)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195486
PNG
(US9670212, 76 3-amino-N-({8-methyl-2-[methyl(2-{me...)
Show SMILES CNC(=O)CN(C)CCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C23H30N8O2/c1-15-6-5-7-16-12-17(13-28-23(33)20-21(24)27-9-8-26-20)22(29-19(15)16)31(4)11-10-30(3)14-18(32)25-2/h5-9,12H,10-11,13-14H2,1-4H3,(H2,24,27)(H,25,32)(H,28,33)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195651
PNG
(US9670212, 94 3-amino-N-{[8-methyl-2-(methyl{2-[me...)
Show SMILES CN(CCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N)C(=O)Cn1nccn1
Show InChI InChI=1S/C24H28N10O2/c1-16-5-4-6-17-13-18(14-28-24(36)21-22(25)27-8-7-26-21)23(31-20(16)17)33(3)12-11-32(2)19(35)15-34-29-9-10-30-34/h4-10,13H,11-12,14-15H2,1-3H3,(H2,25,27)(H,28,36)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195666
PNG
(US9670212, 102 3-amino-N-{[8-methyl-2-(methyl{2-[m...)
Show SMILES CN(CCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N)C(=O)[C@H]1CCCN1
Show InChI InChI=1S/C25H32N8O2/c1-16-6-4-7-17-14-18(15-30-24(34)21-22(26)29-11-10-28-21)23(31-20(16)17)32(2)12-13-33(3)25(35)19-8-5-9-27-19/h4,6-7,10-11,14,19,27H,5,8-9,12-13,15H2,1-3H3,(H2,26,29)(H,30,34)/t19-/m1/s1
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195709
PNG
(US9670212, 113 3-amino-N-{[8-methyl-2-(methyl{2-[m...)
Show SMILES CN(CCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N)C(=O)[C@@H]1CCCN1C
Show InChI InChI=1S/C26H34N8O2/c1-17-7-5-8-18-15-19(16-30-25(35)22-23(27)29-11-10-28-22)24(31-21(17)18)33(3)13-14-34(4)26(36)20-9-6-12-32(20)2/h5,7-8,10-11,15,20H,6,9,12-14,16H2,1-4H3,(H2,27,29)(H,30,35)/t20-/m0/s1
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195731
PNG
(US9670212, 121 3-amino-N-({2-[(2-hydroxyethyl)(met...)
Show SMILES CN(CCO)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C19H22N6O2/c1-12-4-3-5-13-10-14(18(24-15(12)13)25(2)8-9-26)11-23-19(27)16-17(20)22-7-6-21-16/h3-7,10,26H,8-9,11H2,1-2H3,(H2,20,22)(H,23,27)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195445
PNG
(US9670212, 60 3-amino-N-({8-methyl-2-[4-(1H-1,2,3-...)
Show SMILES Cc1cccc2cc(CNC(=O)c3nccnc3N)c(nc12)N1CCCN(CC1)C(=O)Cn1ccnn1
Show InChI InChI=1S/C25H28N10O2/c1-17-4-2-5-18-14-19(15-29-25(37)22-23(26)28-7-6-27-22)24(31-21(17)18)34-10-3-9-33(12-13-34)20(36)16-35-11-8-30-32-35/h2,4-8,11,14H,3,9-10,12-13,15-16H2,1H3,(H2,26,28)(H,29,37)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195454
PNG
(US9670212, 69 3-amino-N-[(3-{3-[(dimethylamino)met...)
Show SMILES CN(C)Cc1cccc(c1)-c1cc2ccccc2nc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C24H24N6O/c1-30(2)15-16-6-5-8-17(12-16)19-13-18-7-3-4-9-20(18)29-21(19)14-28-24(31)22-23(25)27-11-10-26-22/h3-13H,14-15H2,1-2H3,(H2,25,27)(H,28,31)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195848
PNG
(US9670212, 183 9-{[8-methyl-2-(3-methylphenyl)quin...)
Show SMILES Cc1cccc(c1)-c1nc2c(C)cccc2cc1Cn1cnc2c(N)ncnc12
Show InChI InChI=1S/C23H20N6/c1-14-5-3-7-16(9-14)20-18(10-17-8-4-6-15(2)19(17)28-20)11-29-13-27-21-22(24)25-12-26-23(21)29/h3-10,12-13H,11H2,1-2H3,(H2,24,25,26)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195762
PNG
(US9670212, 139 3-amino-N-{[2-(1,4-diazepan-1-yl)-8...)
Show SMILES Cc1cccc2cc(CNC(=O)c3nccnc3N)c(nc12)N1CCCNCC1
Show InChI InChI=1S/C21H25N7O/c1-14-4-2-5-15-12-16(13-26-21(29)18-19(22)25-8-7-24-18)20(27-17(14)15)28-10-3-6-23-9-11-28/h2,4-5,7-8,12,23H,3,6,9-11,13H2,1H3,(H2,22,25)(H,26,29)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195760
PNG
(US9670212, 137 3-amino-N-({2-[4-(N,N-dimethylglycy...)
Show SMILES CN(C)CC(=O)N1CCCN(CC1)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C25H32N8O2/c1-17-6-4-7-18-14-19(15-29-25(35)22-23(26)28-9-8-27-22)24(30-21(17)18)33-11-5-10-32(12-13-33)20(34)16-31(2)3/h4,6-9,14H,5,10-13,15-16H2,1-3H3,(H2,26,28)(H,29,35)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195763
PNG
(US9670212, 140 3-amino-N-{[8-methyl-2-(4-methyl-1,...)
Show SMILES CN1CCCN(CC1)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C22H27N7O/c1-15-5-3-6-16-13-17(14-26-22(30)19-20(23)25-8-7-24-19)21(27-18(15)16)29-10-4-9-28(2)11-12-29/h3,5-8,13H,4,9-12,14H2,1-2H3,(H2,23,25)(H,26,30)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195348
PNG
(US9670212, 46 3-amino-N-({2-[bis(pyridin-3-ylmethy...)
Show SMILES Cc1cccc2cc(CNC(=O)c3nccnc3N)c(nc12)N(Cc1cccnc1)Cc1cccnc1
Show InChI InChI=1S/C28H26N8O/c1-19-5-2-8-22-13-23(16-34-28(37)25-26(29)33-12-11-32-25)27(35-24(19)22)36(17-20-6-3-9-30-14-20)18-21-7-4-10-31-15-21/h2-15H,16-18H2,1H3,(H2,29,33)(H,34,37)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195736
PNG
(US9670212, 124 N-{[2-(4-acetylpiperazin-1-yl)-8-me...)
Show SMILES CC(=O)N1CCN(CC1)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C22H25N7O2/c1-14-4-3-5-16-12-17(13-26-22(31)19-20(23)25-7-6-24-19)21(27-18(14)16)29-10-8-28(9-11-29)15(2)30/h3-7,12H,8-11,13H2,1-2H3,(H2,23,25)(H,26,31)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195735
PNG
(US9670212, 123 3-amino-N-({2-[(2R,5S)-2,5-dimethyl...)
Show SMILES C[C@@H]1CN([C@H](C)CN1)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C22H27N7O/c1-13-5-4-6-16-9-17(11-27-22(30)19-20(23)25-8-7-24-19)21(28-18(13)16)29-12-14(2)26-10-15(29)3/h4-9,14-15,26H,10-12H2,1-3H3,(H2,23,25)(H,27,30)/t14-,15-/m1/s1
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195455
PNG
(US9670212, 70 3-amino-N-({3-[2-(morpholin-4-ylmeth...)
Show SMILES Nc1nccnc1C(=O)NCc1nc2ccccc2cc1-c1ccccc1CN1CCOCC1
Show InChI InChI=1S/C26H26N6O2/c27-25-24(28-9-10-29-25)26(33)30-16-23-21(15-18-5-2-4-8-22(18)31-23)20-7-3-1-6-19(20)17-32-11-13-34-14-12-32/h1-10,15H,11-14,16-17H2,(H2,27,29)(H,30,33)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195449
PNG
(US9670212, 64 3-amino-N-({8-methyl-2-[4-(pyridin-3...)
Show SMILES Cc1cccc2cc(CNC(=O)c3nccnc3N)c(nc12)N1CCCN(Cc2cccnc2)CC1
Show InChI InChI=1S/C27H30N8O/c1-19-5-2-7-21-15-22(17-32-27(36)24-25(28)31-10-9-30-24)26(33-23(19)21)35-12-4-11-34(13-14-35)18-20-6-3-8-29-16-20/h2-3,5-10,15-16H,4,11-14,17-18H2,1H3,(H2,28,31)(H,32,36)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195851
PNG
(US9670212, 186 9-({2-[2-(ethyloxy)phenyl]-8-methyl...)
Show SMILES Cc1cccc2cc(Cn3cnc4c(N)ncnc34)c(nc12)-c1ccccc1CO
Show InChI InChI=1S/C23H20N6O/c1-14-5-4-7-15-9-17(10-29-13-27-21-22(24)25-12-26-23(21)29)20(28-19(14)15)18-8-3-2-6-16(18)11-30/h2-9,12-13,30H,10-11H2,1H3,(H2,24,25,26)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195849
PNG
(US9670212, 184 9-{[8-methyl-2-(3-{[2-(methyloxy)et...)
Show SMILES COCCOc1cccc(c1)-c1nc2c(C)cccc2cc1Cn1cnc2c(N)ncnc12
Show InChI InChI=1S/C25H24N6O2/c1-16-5-3-6-17-11-19(13-31-15-29-23-24(26)27-14-28-25(23)31)22(30-21(16)17)18-7-4-8-20(12-18)33-10-9-32-2/h3-8,11-12,14-15H,9-10,13H2,1-2H3,(H2,26,27,28)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195479
PNG
(US9670212, 75 3-amino-N-{1-[3-(2-methylphenyl)quin...)
Show SMILES CC(NC(=O)c1nccnc1N)c1nc2ccccc2cc1-c1ccccc1C
Show InChI InChI=1S/C23H21N5O/c1-14-7-3-5-9-17(14)18-13-16-8-4-6-10-19(16)28-20(18)15(2)27-23(29)21-22(24)26-12-11-25-21/h3-13,15H,1-2H3,(H2,24,26)(H,27,29)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195704
PNG
(US9670212, 111 3-amino-N-{[2-(1H-imidazol-1-yl)-8-...)
Show SMILES Cc1cccc2cc(CNC(=O)c3nccnc3N)c(nc12)-n1ccnc1
Show InChI InChI=1S/C19H17N7O/c1-12-3-2-4-13-9-14(18(25-15(12)13)26-8-7-21-11-26)10-24-19(27)16-17(20)23-6-5-22-16/h2-9,11H,10H2,1H3,(H2,20,23)(H,24,27)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195407
PNG
(US9670212, 56 3-amino-N-[(3-{2-[(dimethylamino)car...)
Show SMILES CN(C)C(=O)c1ccccc1-c1cc2ccccc2nc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C24H22N6O2/c1-30(2)24(32)17-9-5-4-8-16(17)18-13-15-7-3-6-10-19(15)29-20(18)14-28-23(31)21-22(25)27-12-11-26-21/h3-13H,14H2,1-2H3,(H2,25,27)(H,28,31)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195726
PNG
(US9670212, 118 3-amino-N-{[5-methyl-3-(2-methylphe...)
Show SMILES Cc1ccccc1-c1cc2c(C)cccc2nc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C23H21N5O/c1-14-6-3-4-8-16(14)18-12-17-15(2)7-5-9-19(17)28-20(18)13-27-23(29)21-22(24)26-11-10-25-21/h3-12H,13H2,1-2H3,(H2,24,26)(H,27,29)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195742
PNG
(US9670212, 130 3-amino-N-[(8-methyl-2-{methyl[2-(m...)
Show SMILES CNCCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C20H25N7O/c1-13-5-4-6-14-11-15(19(26-16(13)14)27(3)10-9-22-2)12-25-20(28)17-18(21)24-8-7-23-17/h4-8,11,22H,9-10,12H2,1-3H3,(H2,21,24)(H,25,28)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195590
PNG
(US9670212, 80 3-amino-N-{[8-methyl-2-(methyl{2-[me...)
Show SMILES CN(CCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N)C(=O)c1cccnc1
Show InChI InChI=1S/C26H28N8O2/c1-17-6-4-7-18-14-20(16-31-25(35)22-23(27)30-11-10-29-22)24(32-21(17)18)33(2)12-13-34(3)26(36)19-8-5-9-28-15-19/h4-11,14-15H,12-13,16H2,1-3H3,(H2,27,30)(H,31,35)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195850
PNG
(US9670212, 185 9-({8-methyl-2-[3-(methyloxy)phenyl...)
Show SMILES COc1cccc(c1)-c1nc2c(C)cccc2cc1Cn1cnc2c(N)ncnc12
Show InChI InChI=1S/C23H20N6O/c1-14-5-3-6-15-9-17(11-29-13-27-21-22(24)25-12-26-23(21)29)20(28-19(14)15)16-7-4-8-18(10-16)30-2/h3-10,12-13H,11H2,1-2H3,(H2,24,25,26)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195616
PNG
(US9670212, 81 3-amino-N-{[8-methyl-2-(methyl{2-[me...)
Show SMILES CN(CCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N)C(=O)c1ccccn1
Show InChI InChI=1S/C26H28N8O2/c1-17-7-6-8-18-15-19(16-31-25(35)22-23(27)30-12-11-29-22)24(32-21(17)18)33(2)13-14-34(3)26(36)20-9-4-5-10-28-20/h4-12,15H,13-14,16H2,1-3H3,(H2,27,30)(H,31,35)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195167
PNG
(US9670212, 13 9-{[8-methyl-2-(octahydroisoquinolin...)
Show SMILES Cc1cccc2cc(Cn3cnc4c(N)ncnc34)c(nc12)N1CCC2CCCCC2C1
Show InChI InChI=1S/C25H29N7/c1-16-5-4-8-18-11-20(13-32-15-29-22-23(26)27-14-28-25(22)32)24(30-21(16)18)31-10-9-17-6-2-3-7-19(17)12-31/h4-5,8,11,14-15,17,19H,2-3,6-7,9-10,12-13H2,1H3,(H2,26,27,28)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195189
PNG
(US9670212, 19 N-{[2-(3,4-dihydroisoquinolin-2(1H)-...)
Show SMILES Cc1cccc2cc(CNc3ncnc4[nH]cnc34)c(nc12)N1CCc2ccccc2C1
Show InChI InChI=1S/C25H23N7/c1-16-5-4-8-18-11-20(12-26-23-22-24(28-14-27-22)30-15-29-23)25(31-21(16)18)32-10-9-17-6-2-3-7-19(17)13-32/h2-8,11,14-15H,9-10,12-13H2,1H3,(H2,26,27,28,29,30)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195413
PNG
(US9670212, 57 3-amino-N-[(8-methyl-2-{4-[(1-methyl...)
Show SMILES Cc1cccc2cc(CNC(=O)c3nccnc3N)c(nc12)N1CCCN(Cc2cccn2C)CC1
Show InChI InChI=1S/C27H32N8O/c1-19-6-3-7-20-16-21(17-31-27(36)24-25(28)30-10-9-29-24)26(32-23(19)20)35-13-5-12-34(14-15-35)18-22-8-4-11-33(22)2/h3-4,6-11,16H,5,12-15,17-18H2,1-2H3,(H2,28,30)(H,31,36)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195450
PNG
(US9670212, 65 3-amino-N-({8-methyl-2-[4-(pyridin-4...)
Show SMILES Cc1cccc2cc(CNC(=O)c3nccnc3N)c(nc12)N1CCCN(Cc2ccncc2)CC1
Show InChI InChI=1S/C27H30N8O/c1-19-4-2-5-21-16-22(17-32-27(36)24-25(28)31-11-10-30-24)26(33-23(19)21)35-13-3-12-34(14-15-35)18-20-6-8-29-9-7-20/h2,4-11,16H,3,12-15,17-18H2,1H3,(H2,28,31)(H,32,36)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195638
PNG
(US9670212, 91 3-amino-N-{[3-(1,3-thiazol-4-yl)quin...)
Show SMILES Nc1nccnc1C(=O)NCc1nc2ccccc2cc1-c1cscn1
Show InChI InChI=1S/C18H14N6OS/c19-17-16(20-5-6-21-17)18(25)22-8-14-12(15-9-26-10-23-15)7-11-3-1-2-4-13(11)24-14/h1-7,9-10H,8H2,(H2,19,21)(H,22,25)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195658
PNG
(US9670212, 95 3-amino-N-({8-methyl-2-[(pyridin-3-y...)
Show SMILES Cc1cccc2cc(CNC(=O)c3nccnc3N)c(NCc3cccnc3)nc12
Show InChI InChI=1S/C22H21N7O/c1-14-4-2-6-16-10-17(13-28-22(30)19-20(23)26-9-8-25-19)21(29-18(14)16)27-12-15-5-3-7-24-11-15/h2-11H,12-13H2,1H3,(H2,23,26)(H,27,29)(H,28,30)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195661
PNG
(US9670212, 97 3-amino-N-({8-methyl-2-[(2-pyridin-3...)
Show SMILES Cc1cccc2cc(CNC(=O)c3nccnc3N)c(NCCc3cccnc3)nc12
Show InChI InChI=1S/C23H23N7O/c1-15-4-2-6-17-12-18(14-29-23(31)20-21(24)27-11-10-26-20)22(30-19(15)17)28-9-7-16-5-3-8-25-13-16/h2-6,8,10-13H,7,9,14H2,1H3,(H2,24,27)(H,28,30)(H,29,31)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195811
PNG
(US9670212, 164 3-[(6-amino-9H-purin-9-yl)methyl]-8...)
Show SMILES CN1CCC(CC1)Nc1nc2c(C)cccc2cc1Cn1cnc2c(N)ncnc12
Show InChI InChI=1S/C22H26N8/c1-14-4-3-5-15-10-16(11-30-13-26-19-20(23)24-12-25-22(19)30)21(28-18(14)15)27-17-6-8-29(2)9-7-17/h3-5,10,12-13,17H,6-9,11H2,1-2H3,(H,27,28)(H2,23,24,25)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195816
PNG
(US9670212, 168 9-{[4-methyl-3-(2-methylphenyl)quin...)
Show SMILES Cc1ccccc1-c1c(Cn2cnc3c(N)ncnc23)nc2ccccc2c1C
Show InChI InChI=1S/C23H20N6/c1-14-7-3-4-8-16(14)20-15(2)17-9-5-6-10-18(17)28-19(20)11-29-13-27-21-22(24)25-12-26-23(21)29/h3-10,12-13H,11H2,1-2H3,(H2,24,25,26)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195817
PNG
(US9670212, 169 7-{[4-methyl-3-(2-methylphenyl)quin...)
Show SMILES Cc1ccccc1-c1c(Cn2cnc3ncnc(N)c23)nc2ccccc2c1C
Show InChI InChI=1S/C23H20N6/c1-14-7-3-4-8-16(14)20-15(2)17-9-5-6-10-18(17)28-19(20)11-29-13-27-23-21(29)22(24)25-12-26-23/h3-10,12-13H,11H2,1-2H3,(H2,24,25,26)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195102
PNG
(US9670212, 6 1-[2-(2-chlorophenyl)-8-methylquinoli...)
Show SMILES COc1cccc(CNCc2cc3cccc(C)c3nc2-c2ccccc2Cl)c1
Show InChI InChI=1S/C25H23ClN2O/c1-17-7-5-9-19-14-20(16-27-15-18-8-6-10-21(13-18)29-2)25(28-24(17)19)22-11-3-4-12-23(22)26/h3-14,27H,15-16H2,1-2H3
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195154
PNG
(US9670212, 11 N-{[2-(2-chlorophenyl)-8-methylquino...)
Show SMILES COc1ccccc1NCc1cc2cccc(C)c2nc1-c1ccccc1Cl
Show InChI InChI=1S/C24H21ClN2O/c1-16-8-7-9-17-14-18(15-26-21-12-5-6-13-22(21)28-2)24(27-23(16)17)19-10-3-4-11-20(19)25/h3-14,26H,15H2,1-2H3
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195194
PNG
(US9670212, 20 N,N'-dimethyl-N-[8-methyl-3-({[4-(me...)
Show SMILES CNCCN(C)c1nc2c(C)cccc2cc1CNc1ccc(OC)cc1
Show InChI InChI=1S/C22H28N4O/c1-16-6-5-7-17-14-18(15-24-19-8-10-20(27-4)11-9-19)22(25-21(16)17)26(3)13-12-23-2/h5-11,14,23-24H,12-13,15H2,1-4H3
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195201
PNG
(US9670212, 21 N,N'-dimethyl-N-[8-methyl-3-(morphol...)
Show SMILES CNCCN(C)c1nc2c(C)cccc2cc1CN1CCOCC1
Show InChI InChI=1S/C19H28N4O/c1-15-5-4-6-16-13-17(14-23-9-11-24-12-10-23)19(21-18(15)16)22(3)8-7-20-2/h4-6,13,20H,7-12,14H2,1-3H3
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195355
PNG
(US9670212, 47 3-amino-N-({2-[bis(pyridin-2-ylmethy...)
Show SMILES Cc1cccc2cc(CNC(=O)c3nccnc3N)c(nc12)N(Cc1ccccn1)Cc1ccccn1
Show InChI InChI=1S/C28H26N8O/c1-19-7-6-8-20-15-21(16-34-28(37)25-26(29)33-14-13-32-25)27(35-24(19)20)36(17-22-9-2-4-11-30-22)18-23-10-3-5-12-31-23/h2-15H,16-18H2,1H3,(H2,29,33)(H,34,37)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195435
PNG
(US9670212, 58 3-amino-N-[(8-methyl-2-{4-[(5-methyl...)
Show SMILES Cc1ccc(CN2CCCN(CC2)c2nc3c(C)cccc3cc2CNC(=O)c2nccnc2N)o1
Show InChI InChI=1S/C27H31N7O2/c1-18-5-3-6-20-15-21(16-31-27(35)24-25(28)30-10-9-29-24)26(32-23(18)20)34-12-4-11-33(13-14-34)17-22-8-7-19(2)36-22/h3,5-10,15H,4,11-14,16-17H2,1-2H3,(H2,28,30)(H,31,35)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195451
PNG
(US9670212, 66 3-amino-N-[(2-{4-[2-(dimethylamino)-...)
Show SMILES CN(C)C(=O)CN1CCCN(CC1)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C25H32N8O2/c1-17-6-4-7-18-14-19(15-29-25(35)22-23(26)28-9-8-27-22)24(30-21(17)18)33-11-5-10-32(12-13-33)16-20(34)31(2)3/h4,6-9,14H,5,10-13,15-16H2,1-3H3,(H2,26,28)(H,29,35)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195619
PNG
(US9670212, 82 3-amino-N-({8-methyl-2-[methyl(2-{me...)
Show SMILES CC(CCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C28H32N6O3S/c1-18-8-10-23(11-9-18)38(36,37)20(3)12-15-34(4)27-22(16-21-7-5-6-19(2)24(21)33-27)17-32-28(35)25-26(29)31-14-13-30-25/h5-11,13-14,16,20H,12,15,17H2,1-4H3,(H2,29,31)(H,32,35)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195646
PNG
(US9670212, 93 3-amino-N-[(3-bromoquinolin-2-yl)met...)
Show SMILES Nc1nccnc1C(=O)NCc1nc2ccccc2cc1Br
Show InChI InChI=1S/C15H12BrN5O/c16-10-7-9-3-1-2-4-11(9)21-12(10)8-20-15(22)13-14(17)19-6-5-18-13/h1-7H,8H2,(H2,17,19)(H,20,22)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195738
PNG
(US9670212, 126 1,1-dimethylethyl{1-[3-({[(3-aminop...)
Show SMILES CN(C1CCN(CC1)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N)C(=O)OC(C)(C)C
Show InChI InChI=1S/C27H35N7O3/c1-17-7-6-8-18-15-19(16-31-25(35)22-23(28)30-12-11-29-22)24(32-21(17)18)34-13-9-20(10-14-34)33(5)26(36)37-27(2,3)4/h6-8,11-12,15,20H,9-10,13-14,16H2,1-5H3,(H2,28,30)(H,31,35)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195766
PNG
(US9670212, 142 3-amino-N-{[3-(2-methylphenyl)quino...)
Show SMILES Cc1ccccc1-c1cc2ccccc2nc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C22H19N5O/c1-14-6-2-4-8-16(14)17-12-15-7-3-5-9-18(15)27-19(17)13-26-22(28)20-21(23)25-11-10-24-20/h2-12H,13H2,1H3,(H2,23,25)(H,26,28)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195084
PNG
(US9670212, 5 N-{[(2-(2-chlorophenyl)-8-methylquino...)
Show SMILES Cc1cccc2cc(CNc3cccc4OCCOc34)c(nc12)-c1ccccc1Cl
Show InChI InChI=1S/C25H21ClN2O2/c1-16-6-4-7-17-14-18(24(28-23(16)17)19-8-2-3-9-20(19)26)15-27-21-10-5-11-22-25(21)30-13-12-29-22/h2-11,14,27H,12-13,15H2,1H3
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195146
PNG
(US9670212, 10 N-{[2-(2-chlorophenyl)-8-methylquino...)
Show SMILES COc1ccc(OCc2cc3cccc(C)c3nc2-c2ccccc2Cl)cc1OC
Show InChI InChI=1S/C25H22ClNO3/c1-16-7-6-8-17-13-18(15-30-19-11-12-22(28-2)23(14-19)29-3)25(27-24(16)17)20-9-4-5-10-21(20)26/h4-14H,15H2,1-3H3
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195208
PNG
(US9670212, 22 N,N'-dimethyl-N-[8-methyl-3-({[3-(me...)
Show SMILES C.CNCCN(C)c1nc2c(C)cccc2cc1COc1cccc(O)c1
Show InChI InChI=1S/C21H25N3O2.CH4/c1-15-6-4-7-16-12-17(14-26-19-9-5-8-18(25)13-19)21(23-20(15)16)24(3)11-10-22-2;/h4-9,12-13,22,25H,10-11,14H2,1-3H3;1H4
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195210
PNG
(US9670212, 23 N,N'-dimethyl-N-[8-methyl-3-({[4-(me...)
Show SMILES CNCCN(C)c1nc2c(C)cccc2cc1COc1ccc(OC)cc1
Show InChI InChI=1S/C22H27N3O2/c1-16-6-5-7-17-14-18(15-27-20-10-8-19(26-4)9-11-20)22(24-21(16)17)25(3)13-12-23-2/h5-11,14,23H,12-13,15H2,1-4H3
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195345
PNG
(US9670212, 44 3-amino-N-{[2-(3-{[2-(dimethylamino)...)
Show SMILES CN(C)C(=O)CNC1CCN(C1)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C24H30N8O2/c1-15-5-4-6-16-11-17(12-29-24(34)21-22(25)27-9-8-26-21)23(30-20(15)16)32-10-7-18(14-32)28-13-19(33)31(2)3/h4-6,8-9,11,18,28H,7,10,12-14H2,1-3H3,(H2,25,27)(H,29,34)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195678
PNG
(US9670212, 107 3-amino-5-chloro-N-{[3-(2-methylphe...)
Show SMILES Cc1ccccc1-c1cc2ccccc2nc1CNC(=O)c1ncc(Cl)nc1N
Show InChI InChI=1S/C22H18ClN5O/c1-13-6-2-4-8-15(13)16-10-14-7-3-5-9-17(14)27-18(16)11-26-22(29)20-21(24)28-19(23)12-25-20/h2-10,12H,11H2,1H3,(H2,24,28)(H,26,29)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195737
PNG
(US9670212, 125 3-amino-N-({2-[(2-hydroxyethyl)amin...)
Show SMILES Cc1cccc2cc(CNC(=O)c3nccnc3N)c(NCCO)nc12
Show InChI InChI=1S/C18H20N6O2/c1-11-3-2-4-12-9-13(17(22-7-8-25)24-14(11)12)10-23-18(26)15-16(19)21-6-5-20-15/h2-6,9,25H,7-8,10H2,1H3,(H2,19,21)(H,22,24)(H,23,26)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195790
PNG
(US9670212, 151 N-{[5-methyl-3-(2-methylphenyl)-4-o...)
Show SMILES Cc1ccccc1-n1c(CNC(=O)c2nccnc2N2CCOCC2)nc2cccc(C)c2c1=O
Show InChI InChI=1S/C26H26N6O3/c1-17-6-3-4-9-20(17)32-21(30-19-8-5-7-18(2)22(19)26(32)34)16-29-25(33)23-24(28-11-10-27-23)31-12-14-35-15-13-31/h3-11H,12-16H2,1-2H3,(H,29,33)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195802
PNG
(US9670212, 159 3-chloro-N-{[5-methyl-3-(2-methylph...)
Show SMILES Cc1ccccc1-n1c(CNC(=O)c2nccnc2Cl)nc2cccc(C)c2c1=O
Show InChI InChI=1S/C22H18ClN5O2/c1-13-6-3-4-9-16(13)28-17(12-26-21(29)19-20(23)25-11-10-24-19)27-15-8-5-7-14(2)18(15)22(28)30/h3-11H,12H2,1-2H3,(H,26,29)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195805
PNG
(US9670212, 162 2-[(6-amino-9H-purin-9-yl)methyl]-3...)
Show SMILES Cc1ccccc1-n1c(Cn2cnc3c(N)ncnc23)nc2ccsc2c1=O
Show InChI InChI=1S/C19H15N7OS/c1-11-4-2-3-5-13(11)26-14(24-12-6-7-28-16(12)19(26)27)8-25-10-23-15-17(20)21-9-22-18(15)25/h2-7,9-10H,8H2,1H3,(H2,20,21,22)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195812
PNG
(US9670212, 165 3-[(6-amino-9H-purin-9-yl)methyl]-8...)
Show SMILES Cc1cccc2cc(Cn3cnc4c(N)ncnc34)c(NC3CCOCC3)nc12
Show InChI InChI=1S/C21H23N7O/c1-13-3-2-4-14-9-15(10-28-12-25-18-19(22)23-11-24-21(18)28)20(27-17(13)14)26-16-5-7-29-8-6-16/h2-4,9,11-12,16H,5-8,10H2,1H3,(H,26,27)(H2,22,23,24)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195822
PNG
(US9670212, 174 2-amino-N-{[5-methyl-3-(2-methylphe...)
Show SMILES Cc1ccccc1-n1c(CNC(=O)c2ccnc(N)c2)nc2cccc(C)c2c1=O
Show InChI InChI=1S/C23H21N5O2/c1-14-6-3-4-9-18(14)28-20(13-26-22(29)16-10-11-25-19(24)12-16)27-17-8-5-7-15(2)21(17)23(28)30/h3-12H,13H2,1-2H3,(H2,24,25)(H,26,29)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195106
PNG
(US9670212, 7 3-({[2-chloro-4-(methyloxy)phenyl]oxy...)
Show SMILES COc1ccc(OCc2cc3cccc(C)c3nc2-c2ccccc2Cl)c(Cl)c1
Show InChI InChI=1S/C24H19Cl2NO2/c1-15-6-5-7-16-12-17(14-29-22-11-10-18(28-2)13-21(22)26)24(27-23(15)16)19-8-3-4-9-20(19)25/h3-13H,14H2,1-2H3
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195187
PNG
(US9670212, 18 N-{[2-(2-chlorophenyl)-8-methylquino...)
Show SMILES C.Cc1cccc2cc(CNc3cccc(O)c3)c(nc12)-c1ccccc1Cl
Show InChI InChI=1S/C23H19ClN2O.CH4/c1-15-6-4-7-16-12-17(14-25-18-8-5-9-19(27)13-18)23(26-22(15)16)20-10-2-3-11-21(20)24;/h2-13,25,27H,14H2,1H3;1H4
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195346
PNG
(US9670212, 45 3-amino-N-[(8-methyl-2-{3-[(1H-1,2,3...)
Show SMILES Cc1cccc2cc(CNC(=O)c3nccnc3N)c(nc12)N1CCC(C1)NC(=O)Cn1ccnn1
Show InChI InChI=1S/C24H26N10O2/c1-15-3-2-4-16-11-17(12-28-24(36)21-22(25)27-7-6-26-21)23(31-20(15)16)33-9-5-18(13-33)30-19(35)14-34-10-8-29-32-34/h2-4,6-8,10-11,18H,5,9,12-14H2,1H3,(H2,25,27)(H,28,36)(H,30,35)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195376
PNG
(US9670212, 50 3-amino-N-{[2-(3-hydroxypropyl)-8-me...)
Show SMILES Cc1cccc2cc(CNC(=O)c3nccnc3N)c(CCCO)nc12
Show InChI InChI=1S/C19H21N5O2/c1-12-4-2-5-13-10-14(15(6-3-9-25)24-16(12)13)11-23-19(26)17-18(20)22-8-7-21-17/h2,4-5,7-8,10,25H,3,6,9,11H2,1H3,(H2,20,22)(H,23,26)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195395
PNG
(US9670212, 54 3-amino-N-({2-[4-(1H-imidazol-1-ylac...)
Show SMILES Cc1cccc2cc(CNC(=O)c3nccnc3N)c(nc12)N1CCCN(CC1)C(=O)Cn1ccnc1
Show InChI InChI=1S/C26H29N9O2/c1-18-4-2-5-19-14-20(15-31-26(37)23-24(27)30-7-6-29-23)25(32-22(18)19)35-10-3-9-34(12-13-35)21(36)16-33-11-8-28-17-33/h2,4-8,11,14,17H,3,9-10,12-13,15-16H2,1H3,(H2,27,30)(H,31,37)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195466
PNG
(US9670212, 72 3-amino-N-({3-[3-(morpholin-4-ylmeth...)
Show SMILES Nc1nccnc1C(=O)NCc1nc2ccccc2cc1-c1cccc(CN2CCOCC2)c1
Show InChI InChI=1S/C26H26N6O2/c27-25-24(28-8-9-29-25)26(33)30-16-23-21(15-20-5-1-2-7-22(20)31-23)19-6-3-4-18(14-19)17-32-10-12-34-13-11-32/h1-9,14-15H,10-13,16-17H2,(H2,27,29)(H,30,33)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195470
PNG
(US9670212, 74 2-amino-N-{[3-(2-methylphenyl)quinol...)
Show SMILES Cc1ccccc1-c1cc2ccccc2nc1CNC(=O)c1cnc(N)nc1
Show InChI InChI=1S/C22H19N5O/c1-14-6-2-4-8-17(14)18-10-15-7-3-5-9-19(15)27-20(18)13-24-21(28)16-11-25-22(23)26-12-16/h2-12H,13H2,1H3,(H,24,28)(H2,23,25,26)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195637
PNG
(US9670212, 90 3-amino-N-{[8-methyl-2-(methyl{2-[me...)
Show SMILES CN(CCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N)c1cnccn1
Show InChI InChI=1S/C24H27N9O/c1-16-5-4-6-17-13-18(14-30-24(34)21-22(25)29-10-9-28-21)23(31-20(16)17)33(3)12-11-32(2)19-15-26-7-8-27-19/h4-10,13,15H,11-12,14H2,1-3H3,(H2,25,29)(H,30,34)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195705
PNG
(US9670212, 112 3-amino-N-{[2-(1H-benzimidazol-1-yl...)
Show SMILES Cc1cccc2cc(CNC(=O)c3nccnc3N)c(nc12)-n1cnc2ccccc12
Show InChI InChI=1S/C23H19N7O/c1-14-5-4-6-15-11-16(12-27-23(31)20-21(24)26-10-9-25-20)22(29-19(14)15)30-13-28-17-7-2-3-8-18(17)30/h2-11,13H,12H2,1H3,(H2,24,26)(H,27,31)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195741
PNG
(US9670212, 129 3-amino-N-[(2-{[2-(dimethylamino)et...)
Show SMILES CN(C)CCNc1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C20H25N7O/c1-13-5-4-6-14-11-15(19(26-16(13)14)24-9-10-27(2)3)12-25-20(28)17-18(21)23-8-7-22-17/h4-8,11H,9-10,12H2,1-3H3,(H2,21,23)(H,24,26)(H,25,28)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195803
PNG
(US9670212, 160 3-amino-6-bromo-N-{[5-methyl-3-(2-m...)
Show SMILES Cc1ccccc1-n1c(CNC(=O)c2nc(Br)cnc2N)nc2cccc(C)c2c1=O
Show InChI InChI=1S/C22H19BrN6O2/c1-12-6-3-4-9-15(12)29-17(27-14-8-5-7-13(2)18(14)22(29)31)11-26-21(30)19-20(24)25-10-16(23)28-19/h3-10H,11H2,1-2H3,(H2,24,25)(H,26,30)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195171
PNG
(US9670212, 14 9-{[2-(3,4-dihydroisoquinolin-2(1H)-...)
Show SMILES Cc1cccc2cc(Cn3cnc4c(N)ncnc34)c(nc12)N1CCc2ccccc2C1
Show InChI InChI=1S/C25H23N7/c1-16-5-4-8-18-11-20(13-32-15-29-22-23(26)27-14-28-25(22)32)24(30-21(16)18)31-10-9-17-6-2-3-7-19(17)12-31/h2-8,11,14-15H,9-10,12-13H2,1H3,(H2,26,27,28)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195126
PNG
(US9670212, 15 3-({[3,5-bis(methyloxy)phenyl]oxy}me...)
Show SMILES C.COc1cc(O)cc(OCc2cc3cccc(C)c3nc2-c2ccccc2Cl)c1
Show InChI InChI=1S/C24H20ClNO3.CH4/c1-15-6-5-7-16-10-17(14-29-20-12-18(27)11-19(13-20)28-2)24(26-23(15)16)21-8-3-4-9-22(21)25;/h3-13,27H,14H2,1-2H3;1H4
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195183
PNG
(US9670212, 17 2-(2-chlorophenyl)-8-methyl-3-(1-{[4...)
Show SMILES COc1ccc(OC(C)c2cc3cccc(C)c3nc2-c2ccccc2Cl)cc1
Show InChI InChI=1S/C25H22ClNO2/c1-16-7-6-8-18-15-22(17(2)29-20-13-11-19(28-3)12-14-20)25(27-24(16)18)21-9-4-5-10-23(21)26/h4-15,17H,1-3H3
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195394
PNG
(US9670212, 53 3-amino-N-({2-[4-(1H-benzimidazol-1-...)
Show SMILES Cc1cccc2cc(CNC(=O)c3nccnc3N)c(nc12)N1CCCN(CC1)C(=O)Cn1cnc2ccccc12
Show InChI InChI=1S/C30H31N9O2/c1-20-6-4-7-21-16-22(17-34-30(41)27-28(31)33-11-10-32-27)29(36-26(20)21)38-13-5-12-37(14-15-38)25(40)18-39-19-35-23-8-2-3-9-24(23)39/h2-4,6-11,16,19H,5,12-15,17-18H2,1H3,(H2,31,33)(H,34,41)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195447
PNG
(US9670212, 62 3-amino-N-[(8-methyl-2-{4-[(1-methyl...)
Show SMILES Cc1cccc2cc(CNC(=O)c3nccnc3N)c(nc12)N1CCCN(Cc2nccn2C)CC1
Show InChI InChI=1S/C26H31N9O/c1-18-5-3-6-19-15-20(16-31-26(36)23-24(27)30-8-7-29-23)25(32-22(18)19)35-11-4-10-34(13-14-35)17-21-28-9-12-33(21)2/h3,5-9,12,15H,4,10-11,13-14,16-17H2,1-2H3,(H2,27,30)(H,31,36)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195586
PNG
(US9670212, 78 3-amino-N-{[8-methyl-2-(methyl{2-[me...)
Show SMILES CN(CCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N)C(=O)c1cnccn1
Show InChI InChI=1S/C25H27N9O2/c1-16-5-4-6-17-13-18(14-31-24(35)21-22(26)30-10-9-29-21)23(32-20(16)17)33(2)11-12-34(3)25(36)19-15-27-7-8-28-19/h4-10,13,15H,11-12,14H2,1-3H3,(H2,26,30)(H,31,35)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195683
PNG
(US9670212, 108 4-amino-N-{[3-(2-methylphenyl)quino...)
Show SMILES Cc1ccccc1-c1cc2ccccc2nc1CNC(=O)c1cncnc1N
Show InChI InChI=1S/C22H19N5O/c1-14-6-2-4-8-16(14)17-10-15-7-3-5-9-19(15)27-20(17)12-25-22(28)18-11-24-13-26-21(18)23/h2-11,13H,12H2,1H3,(H,25,28)(H2,23,24,26)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195734
PNG
(US9670212, 122 3-amino-N-[(8-methyl-2-{[2-(methyla...)
Show SMILES CNCCOc1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C19H22N6O2/c1-12-4-3-5-13-10-14(19(25-15(12)13)27-9-8-21-2)11-24-18(26)16-17(20)23-7-6-22-16/h3-7,10,21H,8-9,11H2,1-2H3,(H2,20,23)(H,24,26)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195796
PNG
(US9670212, 157 2-(2-aminoethyl)-5-methyl-3-(2-meth...)
Show SMILES Cc1ccccc1-n1c(CCN)nc2cccc(C)c2c1=O
Show InChI InChI=1S/C18H19N3O/c1-12-6-3-4-9-15(12)21-16(10-11-19)20-14-8-5-7-13(2)17(14)18(21)22/h3-9H,10-11,19H2,1-2H3
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195804
PNG
(US9670212, 161 3-amino-N-{[5-methyl-3-(2-methylphe...)
Show SMILES Cc1ccccc1-n1c(CNC(=O)c2ncccc2N)nc2cccc(C)c2c1=O
Show InChI InChI=1S/C23H21N5O2/c1-14-7-3-4-11-18(14)28-19(13-26-22(29)21-16(24)9-6-12-25-21)27-17-10-5-8-15(2)20(17)23(28)30/h3-12H,13,24H2,1-2H3,(H,26,29)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195856
PNG
(US9670212, 191 9-{[2-(2-methylphenyl)quinolin-3-yl...)
Show SMILES Cc1ccccc1-c1nc2ccccc2cc1Cn1cnc2c(N)ncnc12
Show InChI InChI=1S/C22H18N6/c1-14-6-2-4-8-17(14)19-16(10-15-7-3-5-9-18(15)27-19)11-28-13-26-20-21(23)24-12-25-22(20)28/h2-10,12-13H,11H2,1H3,(H2,23,24,25)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195212
PNG
(US9670212, 24 N,N'-dimethyl-N-[8-methyl-3-({[3-(me...)
Show SMILES C.CNCCN(C)c1nc2c(C)cccc2cc1CNc1cccc(O)c1
Show InChI InChI=1S/C21H26N4O.CH4/c1-15-6-4-7-16-12-17(14-23-18-8-5-9-19(26)13-18)21(24-20(15)16)25(3)11-10-22-2;/h4-9,12-13,22-23,26H,10-11,14H2,1-3H3;1H4
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195635
PNG
(US9670212, 88 3-amino-N-({8-methyl-2-[methyl(2-pyr...)
Show SMILES CN(CCc1ccccn1)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C24H25N7O/c1-16-6-5-7-17-14-18(15-29-24(32)21-22(25)28-12-11-27-21)23(30-20(16)17)31(2)13-9-19-8-3-4-10-26-19/h3-8,10-12,14H,9,13,15H2,1-2H3,(H2,25,28)(H,29,32)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195730
PNG
(US9670212, 120 9-{[3-(2-methylphenyl)naphthalen-2-...)
Show SMILES Cc1ccccc1-c1cc2ccccc2cc1Cn1cnc2c(N)ncnc12
Show InChI InChI=1S/C23H19N5/c1-15-6-2-5-9-19(15)20-11-17-8-4-3-7-16(17)10-18(20)12-28-14-27-21-22(24)25-13-26-23(21)28/h2-11,13-14H,12H2,1H3,(H2,24,25,26)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195744
PNG
(US9670212, 132 N-5-{[3-(2-methylphenyl)quinolin-2-...)
Show SMILES Cc1ccccc1-c1cc2ccccc2nc1CNc1cncnc1N
Show InChI InChI=1S/C21H19N5/c1-14-6-2-4-8-16(14)17-10-15-7-3-5-9-18(15)26-19(17)12-24-20-11-23-13-25-21(20)22/h2-11,13,24H,12H2,1H3,(H2,22,23,25)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195764
PNG
(US9670212, 141 3-bromo-N-{[3-(2-methylphenyl)quino...)
Show SMILES Cc1ccccc1-c1cc2ccccc2nc1CNc1ncnc2[nH]nc(Br)c12
Show InChI InChI=1S/C22H17BrN6/c1-13-6-2-4-8-15(13)16-10-14-7-3-5-9-17(14)27-18(16)11-24-21-19-20(23)28-29-22(19)26-12-25-21/h2-10,12H,11H2,1H3,(H2,24,25,26,28,29)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195786
PNG
(US9670212, 147 3-amino-N-[(8-methyl-2-piperidin-1-...)
Show SMILES Cc1cccc2cc(CNC(=O)c3nccnc3N)c(nc12)N1CCCCC1
Show InChI InChI=1S/C21H24N6O/c1-14-6-5-7-15-12-16(13-25-21(28)18-19(22)24-9-8-23-18)20(26-17(14)15)27-10-3-2-4-11-27/h5-9,12H,2-4,10-11,13H2,1H3,(H2,22,24)(H,25,28)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195814
PNG
(US9670212, 167 3-[(6-amino-9H-purin-9-yl)methyl]-8...)
Show SMILES COCCNc1nc2c(C)cccc2cc1Cn1cnc2c(N)ncnc12
Show InChI InChI=1S/C19H21N7O/c1-12-4-3-5-13-8-14(18(25-15(12)13)21-6-7-27-2)9-26-11-24-16-17(20)22-10-23-19(16)26/h3-5,8,10-11H,6-7,9H2,1-2H3,(H,21,25)(H2,20,22,23)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195825
PNG
(US9670212, 176 2-amino-N-{[5-methyl-3-(2-methylphe...)
Show SMILES Cc1ccccc1-n1c(CNC(=O)c2cccnc2N)nc2cccc(C)c2c1=O
Show InChI InChI=1S/C23H21N5O2/c1-14-7-3-4-11-18(14)28-19(13-26-22(29)16-9-6-12-25-21(16)24)27-17-10-5-8-15(2)20(17)23(28)30/h3-12H,13H2,1-2H3,(H2,24,25)(H,26,29)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195179
PNG
(US9670212, 16 2-(2-chlorophenyl)-8-methyl-3-({[4-(...)
Show SMILES COc1ccc(OCc2cc3cccc(C)c3nc2-c2ccccc2Cl)cc1
Show InChI InChI=1S/C24H20ClNO2/c1-16-6-5-7-17-14-18(15-28-20-12-10-19(27-2)11-13-20)24(26-23(16)17)21-8-3-4-9-22(21)25/h3-14H,15H2,1-2H3
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195232
PNG
(US9670212, 29 N-{3-[5-(3-aminopyrazin-2-yl)-1,3,4-...)
Show SMILES CNCCN(C)c1nc2c(C)cccc2cc1-c1nnc(o1)-c1nccnc1N
Show InChI InChI=1S/C20H22N8O/c1-12-5-4-6-13-11-14(18(25-15(12)13)28(3)10-9-22-2)19-26-27-20(29-19)16-17(21)24-8-7-23-16/h4-8,11,22H,9-10H2,1-3H3,(H2,21,24)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195324
PNG
(US9670212, 40 N-methyl-N'-[(8-methyl-2-{methyl[2-(...)
Show SMILES CNCCN(C)c1nc2c(C)cccc2cc1CNC(=O)C1(CC1)C(=O)NC
Show InChI InChI=1S/C21H29N5O2/c1-14-6-5-7-15-12-16(18(25-17(14)15)26(4)11-10-22-2)13-24-20(28)21(8-9-21)19(27)23-3/h5-7,12,22H,8-11,13H2,1-4H3,(H,23,27)(H,24,28)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195446
PNG
(US9670212, 61 3-amino-N-({8-methyl-2-[4-(2H-1,2,3-...)
Show SMILES Cc1cccc2cc(CNC(=O)c3nccnc3N)c(nc12)N1CCCN(CC1)C(=O)Cn1nccn1
Show InChI InChI=1S/C25H28N10O2/c1-17-4-2-5-18-14-19(15-29-25(37)22-23(26)28-7-6-27-22)24(32-21(17)18)34-11-3-10-33(12-13-34)20(36)16-35-30-8-9-31-35/h2,4-9,14H,3,10-13,15-16H2,1H3,(H2,26,28)(H,29,37)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195660
PNG
(US9670212, 96 3-amino-N-({8-methyl-2-[(2-pyridin-2...)
Show SMILES Cc1cccc2cc(CNC(=O)c3nccnc3N)c(NCCc3ccccn3)nc12
Show InChI InChI=1S/C23H23N7O/c1-15-5-4-6-16-13-17(14-29-23(31)20-21(24)27-12-11-26-20)22(30-19(15)16)28-10-8-18-7-2-3-9-25-18/h2-7,9,11-13H,8,10,14H2,1H3,(H2,24,27)(H,28,30)(H,29,31)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195674
PNG
(US9670212, 104 3-amino-N-[(8-methyl-2-{methyl[2-(m...)
Show SMILES COCCN(C)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C20H24N6O2/c1-13-5-4-6-14-11-15(19(25-16(13)14)26(2)9-10-28-3)12-24-20(27)17-18(21)23-8-7-22-17/h4-8,11H,9-10,12H2,1-3H3,(H2,21,23)(H,24,27)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195677
PNG
(US9670212, 106 3-amino-5-(methyloxy)-N-{[3-(2-meth...)
Show SMILES C.Cc1ccccc1-c1cc2ccccc2nc1CNC(=O)c1ncc(O)nc1N
Show InChI InChI=1S/C22H19N5O2.CH4/c1-13-6-2-4-8-15(13)16-10-14-7-3-5-9-17(14)26-18(16)11-25-22(29)20-21(23)27-19(28)12-24-20;/h2-10,12H,11H2,1H3,(H,25,29)(H3,23,27,28);1H4
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195801
PNG
(US9670212, 158 3-({[3,5-bis(methyloxy)phenyl]methy...)
Show SMILES C.COc1cc(O)cc(COc2cc3cccc(C)c3nc2-c2ccccc2C)c1
Show InChI InChI=1S/C25H23NO3.CH4/c1-16-7-4-5-10-22(16)25-23(13-19-9-6-8-17(2)24(19)26-25)29-15-18-11-20(27)14-21(12-18)28-3;/h4-14,27H,15H2,1-3H3;1H4
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195855
PNG
(US9670212, 190 9-{[3-(2-methylphenyl)quinoxalin-2-...)
Show SMILES Cc1ccccc1-c1nc2ccccc2nc1Cn1cnc2c(N)ncnc12
Show InChI InChI=1S/C21H17N7/c1-13-6-2-3-7-14(13)18-17(26-15-8-4-5-9-16(15)27-18)10-28-12-25-19-20(22)23-11-24-21(19)28/h2-9,11-12H,10H2,1H3,(H2,22,23,24)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195116
PNG
(US9670212, 8 3-[(1,3-benzodioxol-5-yloxy)methyl]-2...)
Show SMILES Cc1cccc2cc(COc3ccc4OCOc4c3)c(nc12)-c1ccccc1Cl
Show InChI InChI=1S/C24H18ClNO3/c1-15-5-4-6-16-11-17(13-27-18-9-10-21-22(12-18)29-14-28-21)24(26-23(15)16)19-7-2-3-8-20(19)25/h2-12H,13-14H2,1H3
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195326
PNG
(US9670212, 41 3-{[3-(4-acetylpiperazin-1-yl)quinox...)
Show SMILES CC(=O)N1CCN(CC1)c1nc2ccccc2nc1Nc1cccc(c1)C(N)=O
Show InChI InChI=1S/C21H22N6O2/c1-14(28)26-9-11-27(12-10-26)21-20(24-17-7-2-3-8-18(17)25-21)23-16-6-4-5-15(13-16)19(22)29/h2-8,13H,9-12H2,1H3,(H2,22,29)(H,23,24)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195405
PNG
(US9670212, 55 3-amino-N-[(8-methyl-2-{4-[(2-methyl...)
Show SMILES Cc1nccn1CC(=O)N1CCCN(CC1)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C27H31N9O2/c1-18-5-3-6-20-15-21(16-32-27(38)24-25(28)31-8-7-30-24)26(33-23(18)20)35-11-4-10-34(13-14-35)22(37)17-36-12-9-29-19(36)2/h3,5-9,12,15H,4,10-11,13-14,16-17H2,1-2H3,(H2,28,31)(H,32,38)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195460
PNG
(US9670212, 71 3-amino-N-({3-[4-(morpholin-4-ylmeth...)
Show SMILES Nc1nccnc1C(=O)NCc1nc2ccccc2cc1-c1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C26H26N6O2/c27-25-24(28-9-10-29-25)26(33)30-16-23-21(15-20-3-1-2-4-22(20)31-23)19-7-5-18(6-8-19)17-32-11-13-34-14-12-32/h1-10,15H,11-14,16-17H2,(H2,27,29)(H,30,33)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195675
PNG
(US9670212, 105 3-amino-N-{[3-(2-methylphenyl)quino...)
Show SMILES Cc1ccccc1-c1cc2ccccc2nc1CNC(=O)c1ncc(nc1N)N1CCOCC1
Show InChI InChI=1S/C26H26N6O2/c1-17-6-2-4-8-19(17)20-14-18-7-3-5-9-21(18)30-22(20)15-29-26(33)24-25(27)31-23(16-28-24)32-10-12-34-13-11-32/h2-9,14,16H,10-13,15H2,1H3,(H2,27,31)(H,29,33)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195739
PNG
(US9670212, 127 3-amino-N-({2-[4-(dimethylamino)pip...)
Show SMILES CN(C)C1CCN(CC1)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C23H29N7O/c1-15-5-4-6-16-13-17(14-27-23(31)20-21(24)26-10-9-25-20)22(28-19(15)16)30-11-7-18(8-12-30)29(2)3/h4-6,9-10,13,18H,7-8,11-12,14H2,1-3H3,(H2,24,26)(H,27,31)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195743
PNG
(US9670212, 131 3-amino-N-[(8-methyl-2-piperazin-1-...)
Show SMILES Cc1cccc2cc(CNC(=O)c3nccnc3N)c(nc12)N1CCNCC1
Show InChI InChI=1S/C20H23N7O/c1-13-3-2-4-14-11-15(12-25-20(28)17-18(21)24-6-5-23-17)19(26-16(13)14)27-9-7-22-8-10-27/h2-6,11,22H,7-10,12H2,1H3,(H2,21,24)(H,25,28)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195761
PNG
(US9670212, 138 3-amino-N-[(2-{[3-(dimethylamino)pr...)
Show SMILES CN(C)CCCNc1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C21H27N7O/c1-14-6-4-7-15-12-16(13-26-21(29)18-19(22)24-10-9-23-18)20(27-17(14)15)25-8-5-11-28(2)3/h4,6-7,9-10,12H,5,8,11,13H2,1-3H3,(H2,22,24)(H,25,27)(H,26,29)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195789
PNG
(US9670212, 150 9-{[8-methyl-2-(5-methyl-2,5-diazab...)
Show SMILES CN1CC2CC1CN2c1nc2c(C)cccc2cc1Cn1cnc2c(N)ncnc12
Show InChI InChI=1S/C22H24N8/c1-13-4-3-5-14-6-15(8-29-12-26-19-20(23)24-11-25-22(19)29)21(27-18(13)14)30-10-16-7-17(30)9-28(16)2/h3-6,11-12,16-17H,7-10H2,1-2H3,(H2,23,24,25)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195792
PNG
(US9670212, 153 N-{3-[(6-amino-9H-purin-9-yl)methyl...)
Show SMILES Cc1cccc2cc(Cn3cnc4c(N)ncnc34)c(NS(C)(=O)=O)nc12
Show InChI InChI=1S/C17H17N7O2S/c1-10-4-3-5-11-6-12(16(22-13(10)11)23-27(2,25)26)7-24-9-21-14-15(18)19-8-20-17(14)24/h3-6,8-9H,7H2,1-2H3,(H,22,23)(H2,18,19,20)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195795
PNG
(US9670212, 156 N-{3-[(6-amino-9H-purin-9-yl)methyl...)
Show SMILES Cc1cccc2cc(Cn3cnc4c(N)ncnc34)c(NS(=O)(=O)c3ccccc3)nc12
Show InChI InChI=1S/C22H19N7O2S/c1-14-6-5-7-15-10-16(11-29-13-26-19-20(23)24-12-25-22(19)29)21(27-18(14)15)28-32(30,31)17-8-3-2-4-9-17/h2-10,12-13H,11H2,1H3,(H,27,28)(H2,23,24,25)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195810
PNG
(US9670212, 163 3-(2-methylphenyl)-2-[(7H-purin-6-y...)
Show SMILES Cc1ccccc1-n1c(CSc2ncnc3nc[nH]c23)nc2ccsc2c1=O
Show InChI InChI=1S/C19H14N6OS2/c1-11-4-2-3-5-13(11)25-14(24-12-6-7-27-16(12)19(25)26)8-28-18-15-17(21-9-20-15)22-10-23-18/h2-7,9-10H,8H2,1H3,(H,20,21,22,23)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195844
PNG
(US9670212, 179 9-{[3-(2-methylphenyl)quinolin-2-yl...)
Show SMILES Cc1ccccc1-c1cc2ccccc2nc1Cn1cnc2c(N)ncnc12
Show InChI InChI=1S/C22H18N6/c1-14-6-2-4-8-16(14)17-10-15-7-3-5-9-18(15)27-19(17)11-28-13-26-20-21(23)24-12-25-22(20)28/h2-10,12-13H,11H2,1H3,(H2,23,24,25)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195845
PNG
(US9670212, 180 9-{[2-(2,3-dimethylphenyl)-8-methyl...)
Show SMILES Cc1cccc(c1C)-c1nc2c(C)cccc2cc1Cn1cnc2c(N)ncnc12
Show InChI InChI=1S/C24H22N6/c1-14-6-5-9-19(16(14)3)21-18(10-17-8-4-7-15(2)20(17)29-21)11-30-13-28-22-23(25)26-12-27-24(22)30/h4-10,12-13H,11H2,1-3H3,(H2,25,26,27)
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM195126
PNG
(US9670212, 15 3-({[3,5-bis(methyloxy)phenyl]oxy}me...)
Show SMILES C.COc1cc(O)cc(OCc2cc3cccc(C)c3nc2-c2ccccc2Cl)c1
Show InChI InChI=1S/C24H20ClNO3.CH4/c1-15-6-5-7-16-10-17(14-29-20-12-18(27)11-19(13-20)28-2)24(26-23(15)16)21-8-3-4-9-22(21)25;/h3-13,27H,14H2,1-2H3;1H4
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Exelixis, Inc.

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%