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Patent code US9670230

Compile Data Set for Download or QSAR
Found 12 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM199556
PNG
(US9670230, 2)
Show SMILES COc1ccc2ccc(CCc3nc4c(C)ncc(C)n4n3)nc2c1
Show InChI InChI=1S/C19H19N5O/c1-12-11-20-13(2)19-22-18(23-24(12)19)9-7-15-6-4-14-5-8-16(25-3)10-17(14)21-15/h4-6,8,10-11H,7,9H2,1-3H3
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n/an/a<10n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM199545
PNG
(US9670230, 1)
Show SMILES Cc1ccc2ccc(CCc3nc4c(C)ncc(C)n4n3)nc2c1
Show InChI InChI=1S/C19H19N5/c1-12-4-5-15-6-7-16(21-17(15)10-12)8-9-18-22-19-14(3)20-11-13(2)24(19)23-18/h4-7,10-11H,8-9H2,1-3H3
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n/an/a<10n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM199961
PNG
(US9670230, 9)
Show SMILES CCC1COc2ccc(CCc3nc4c(C)ncc(C)n4n3)nc2N1
Show InChI InChI=1S/C18H22N6O/c1-4-13-10-25-15-7-5-14(21-17(15)20-13)6-8-16-22-18-12(3)19-9-11(2)24(18)23-16/h5,7,9,13H,4,6,8,10H2,1-3H3,(H,20,21)
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM199941
PNG
(US9670230, 5)
Show SMILES C[C@H]1CCc2ccc(CCc3nc4c(C)ncc(C)n4n3)nc2N1
Show InChI InChI=1S/C18H22N6/c1-11-4-5-14-6-7-15(21-17(14)20-11)8-9-16-22-18-13(3)19-10-12(2)24(18)23-16/h6-7,10-11H,4-5,8-9H2,1-3H3,(H,20,21)/t11-/m0/s1
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM199959
PNG
(US9670230, 7)
Show SMILES C[C@@H]1COc2ccc(CCc3nc4c(C)ncc(C)n4n3)nc2N1
Show InChI InChI=1S/C17H20N6O/c1-10-9-24-14-6-4-13(20-16(14)19-10)5-7-15-21-17-12(3)18-8-11(2)23(17)22-15/h4,6,8,10H,5,7,9H2,1-3H3,(H,19,20)/t10-/m1/s1
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM199942
PNG
(US9670230, 6)
Show SMILES CC1COc2ccc(CCc3nc4c(C)ncc(C)n4n3)nc2N1
Show InChI InChI=1S/C17H20N6O/c1-10-9-24-14-6-4-13(20-16(14)19-10)5-7-15-21-17-12(3)18-8-11(2)23(17)22-15/h4,6,8,10H,5,7,9H2,1-3H3,(H,19,20)
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM199940
PNG
(US9670230, 4)
Show SMILES C[C@@H]1CCc2ccc(CCc3nc4c(C)ncc(C)n4n3)nc2N1
Show InChI InChI=1S/C18H22N6/c1-11-4-5-14-6-7-15(21-17(14)20-11)8-9-16-22-18-13(3)19-10-12(2)24(18)23-16/h6-7,10-11H,4-5,8-9H2,1-3H3,(H,20,21)/t11-/m1/s1
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n/an/a 55n/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM199939
PNG
(US9670230, 3)
Show SMILES CC1CCc2ccc(CCc3nc4c(C)ncc(C)n4n3)nc2N1
Show InChI InChI=1S/C18H22N6/c1-11-4-5-14-6-7-15(21-17(14)20-11)8-9-16-22-18-13(3)19-10-12(2)24(18)23-16/h6-7,10-11H,4-5,8-9H2,1-3H3,(H,20,21)
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM199960
PNG
(US9670230, 8)
Show SMILES C[C@H]1COc2ccc(CCc3nc4c(C)ncc(C)n4n3)nc2N1
Show InChI InChI=1S/C17H20N6O/c1-10-9-24-14-6-4-13(20-16(14)19-10)5-7-15-21-17-12(3)18-8-11(2)23(17)22-15/h4,6,8,10H,5,7,9H2,1-3H3,(H,19,20)/t10-/m0/s1
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM199966
PNG
(US9670230, 12)
Show SMILES Cc1cnc(C)c2nc(CCc3ccc4OCC(C)(C)Nc4n3)nn12
Show InChI InChI=1S/C18H22N6O/c1-11-9-19-12(2)17-21-15(23-24(11)17)8-6-13-5-7-14-16(20-13)22-18(3,4)10-25-14/h5,7,9H,6,8,10H2,1-4H3,(H,20,22)
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM199964
PNG
(US9670230, 10)
Show SMILES CC1COc2ccc(CCc3nc4c(C)ncc(C)n4n3)nc2N1C
Show InChI InChI=1S/C18H22N6O/c1-11-9-19-13(3)17-21-16(22-24(11)17)8-6-14-5-7-15-18(20-14)23(4)12(2)10-25-15/h5,7,9,12H,6,8,10H2,1-4H3
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...


Citation and Details
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM199965
PNG
(US9670230, 11)
Show SMILES CCC1COc2ccc(CCc3nc4c(C)ncc(C)n4n3)nc2N1C
Show InChI InChI=1S/C19H24N6O/c1-5-15-11-26-16-8-6-14(21-19(16)24(15)4)7-9-17-22-18-13(3)20-10-12(2)25(18)23-17/h6,8,10,15H,5,7,9,11H2,1-4H3
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Sunovion Pharmaceuticals Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%