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Patent code US9676712

Compile Data Set for Download or QSAR
Found 15 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM179834
PNG
(US9676712, 2C)
Show SMILES CC(CCCc1ccccc1)[C@@H](O)\C=C\[C@H]1CCC(=O)N1CCCCCCC(O)=O
Show InChI InChI=1S/C25H37NO4/c1-20(10-9-13-21-11-5-4-6-12-21)23(27)17-15-22-16-18-24(28)26(22)19-8-3-2-7-14-25(29)30/h4-6,11-12,15,17,20,22-23,27H,2-3,7-10,13-14,16,18-19H2,1H3,(H,29,30)/b17-15+/t20?,22-,23-/m0/s1
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US Patent
2.10n/a 5.70n/an/an/an/an/an/a



CAYMAN CHEMICAL COMPANY, INC.

US Patent


Assay Description
200 μl in 96-well plate. Cell membrane homogenates (20 μg protein) are incubated for 120 min at 22 C. with 0.5 nM [3H]PGE2 in the absence ...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM179827
PNG
(US9676712, 1C)
Show SMILES O[C@H](CCCCc1ccccc1)\C=C\[C@H]1CCC(=O)N1CCCCCCC(O)=O
Show InChI InChI=1S/C24H35NO4/c26-22(13-8-7-12-20-10-4-3-5-11-20)17-15-21-16-18-23(27)25(21)19-9-2-1-6-14-24(28)29/h3-5,10-11,15,17,21-22,26H,1-2,6-9,12-14,16,18-19H2,(H,28,29)/b17-15+/t21-,22+/m0/s1
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3.80n/a 10n/an/an/an/an/an/a



CAYMAN CHEMICAL COMPANY, INC.

US Patent


Assay Description
200 μl in 96-well plate. Cell membrane homogenates (20 μg protein) are incubated for 120 min at 22 C. with 0.5 nM [3H]PGE2 in the absence ...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM179987
PNG
(US9676712, 4D)
Show SMILES CC(CCCc1ccccc1)[C@H](O)\C=C\[C@H]1CCC(=O)N1CCCc1ccc(s1)C(O)=O
Show InChI InChI=1S/C26H33NO4S/c1-19(7-5-10-20-8-3-2-4-9-20)23(28)15-12-21-13-17-25(29)27(21)18-6-11-22-14-16-24(32-22)26(30)31/h2-4,8-9,12,14-16,19,21,23,28H,5-7,10-11,13,17-18H2,1H3,(H,30,31)/b15-12+/t19?,21-,23+/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



CAYMAN CHEMICAL COMPANY, INC.

US Patent


Assay Description
1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 μl of reduced serum medium containing 0.5% FBS. Place ...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM179827
PNG
(US9676712, 1C)
Show SMILES O[C@H](CCCCc1ccccc1)\C=C\[C@H]1CCC(=O)N1CCCCCCC(O)=O
Show InChI InChI=1S/C24H35NO4/c26-22(13-8-7-12-20-10-4-3-5-11-20)17-15-21-16-18-23(27)25(21)19-9-2-1-6-14-24(28)29/h3-5,10-11,15,17,21-22,26H,1-2,6-9,12-14,16,18-19H2,(H,28,29)/b17-15+/t21-,22+/m0/s1
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n/an/an/an/a 1.37n/an/an/an/a



CAYMAN CHEMICAL COMPANY, INC.

US Patent


Assay Description
1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 μL of reduced serum medium containing 0.5% FBE. Place ...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM179827
PNG
(US9676712, 1C)
Show SMILES O[C@H](CCCCc1ccccc1)\C=C\[C@H]1CCC(=O)N1CCCCCCC(O)=O
Show InChI InChI=1S/C24H35NO4/c26-22(13-8-7-12-20-10-4-3-5-11-20)17-15-21-16-18-23(27)25(21)19-9-2-1-6-14-24(28)29/h3-5,10-11,15,17,21-22,26H,1-2,6-9,12-14,16,18-19H2,(H,28,29)/b17-15+/t21-,22+/m0/s1
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n/an/an/an/a 0.0140n/an/an/an/a



CAYMAN CHEMICAL COMPANY, INC.

US Patent


Assay Description
1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 μl of reduced serum medium containing 0.5% FBS. Place ...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM179986
PNG
(US9676712, 3C)
Show SMILES CC(CCCc1ccccc1)[C@@H](O)\C=C\[C@H]1CCC(=O)N1CC#Cc1ccc(s1)C(O)=O
Show InChI InChI=1S/C26H29NO4S/c1-19(7-5-10-20-8-3-2-4-9-20)23(28)15-12-21-13-17-25(29)27(21)18-6-11-22-14-16-24(32-22)26(30)31/h2-4,8-9,12,14-16,19,21,23,28H,5,7,10,13,17-18H2,1H3,(H,30,31)/b15-12+/t19?,21-,23-/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



CAYMAN CHEMICAL COMPANY, INC.

US Patent


Assay Description
1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 μl of reduced serum medium containing 0.5% FBS. Place ...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM179985
PNG
(US9676712, 3D)
Show SMILES CC(CCCc1ccccc1)[C@H](O)\C=C\[C@H]1CCC(=O)N1CC#Cc1ccc(s1)C(O)=O
Show InChI InChI=1S/C26H29NO4S/c1-19(7-5-10-20-8-3-2-4-9-20)23(28)15-12-21-13-17-25(29)27(21)18-6-11-22-14-16-24(32-22)26(30)31/h2-4,8-9,12,14-16,19,21,23,28H,5,7,10,13,17-18H2,1H3,(H,30,31)/b15-12+/t19?,21-,23+/m0/s1
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n/an/an/an/a 32n/an/an/an/a



CAYMAN CHEMICAL COMPANY, INC.

US Patent


Assay Description
1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 μl of reduced serum medium containing 0.5% FBS. Place ...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM179834
PNG
(US9676712, 2C)
Show SMILES CC(CCCc1ccccc1)[C@@H](O)\C=C\[C@H]1CCC(=O)N1CCCCCCC(O)=O
Show InChI InChI=1S/C25H37NO4/c1-20(10-9-13-21-11-5-4-6-12-21)23(27)17-15-22-16-18-24(28)26(22)19-8-3-2-7-14-25(29)30/h4-6,11-12,15,17,20,22-23,27H,2-3,7-10,13-14,16,18-19H2,1H3,(H,29,30)/b17-15+/t20?,22-,23-/m0/s1
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n/an/an/an/a 0.00700n/an/an/an/a



CAYMAN CHEMICAL COMPANY, INC.

US Patent


Assay Description
1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 μL of reduced serum medium containing 0.5% FBE. Place ...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM179834
PNG
(US9676712, 2C)
Show SMILES CC(CCCc1ccccc1)[C@@H](O)\C=C\[C@H]1CCC(=O)N1CCCCCCC(O)=O
Show InChI InChI=1S/C25H37NO4/c1-20(10-9-13-21-11-5-4-6-12-21)23(27)17-15-22-16-18-24(28)26(22)19-8-3-2-7-14-25(29)30/h4-6,11-12,15,17,20,22-23,27H,2-3,7-10,13-14,16,18-19H2,1H3,(H,29,30)/b17-15+/t20?,22-,23-/m0/s1
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n/an/an/an/a>1.00E+3n/an/an/an/a



CAYMAN CHEMICAL COMPANY, INC.

US Patent


Assay Description
1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 μl of reduced serum medium containing 0.5% FBS. Place ...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM179985
PNG
(US9676712, 3D)
Show SMILES CC(CCCc1ccccc1)[C@H](O)\C=C\[C@H]1CCC(=O)N1CC#Cc1ccc(s1)C(O)=O
Show InChI InChI=1S/C26H29NO4S/c1-19(7-5-10-20-8-3-2-4-9-20)23(28)15-12-21-13-17-25(29)27(21)18-6-11-22-14-16-24(32-22)26(30)31/h2-4,8-9,12,14-16,19,21,23,28H,5,7,10,13,17-18H2,1H3,(H,30,31)/b15-12+/t19?,21-,23+/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



CAYMAN CHEMICAL COMPANY, INC.

US Patent


Assay Description
1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 μl of reduced serum medium containing 0.5% FBS. Place ...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM179827
PNG
(US9676712, 1C)
Show SMILES O[C@H](CCCCc1ccccc1)\C=C\[C@H]1CCC(=O)N1CCCCCCC(O)=O
Show InChI InChI=1S/C24H35NO4/c26-22(13-8-7-12-20-10-4-3-5-11-20)17-15-21-16-18-23(27)25(21)19-9-2-1-6-14-24(28)29/h3-5,10-11,15,17,21-22,26H,1-2,6-9,12-14,16,18-19H2,(H,28,29)/b17-15+/t21-,22+/m0/s1
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n/an/an/an/a>1.00E+3n/an/an/an/a



CAYMAN CHEMICAL COMPANY, INC.

US Patent


Assay Description
1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 μl of reduced serum medium containing 0.5% FBS. Place ...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM179834
PNG
(US9676712, 2C)
Show SMILES CC(CCCc1ccccc1)[C@@H](O)\C=C\[C@H]1CCC(=O)N1CCCCCCC(O)=O
Show InChI InChI=1S/C25H37NO4/c1-20(10-9-13-21-11-5-4-6-12-21)23(27)17-15-22-16-18-24(28)26(22)19-8-3-2-7-14-25(29)30/h4-6,11-12,15,17,20,22-23,27H,2-3,7-10,13-14,16,18-19H2,1H3,(H,29,30)/b17-15+/t20?,22-,23-/m0/s1
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n/an/an/an/a 0.00100n/an/an/an/a



CAYMAN CHEMICAL COMPANY, INC.

US Patent


Assay Description
1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 μl of reduced serum medium containing 0.5% FBS. Place ...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM179991
PNG
(US9676712, 4C)
Show SMILES CC(CCCc1ccccc1)[C@@H](O)\C=C\[C@H]1CCC(=O)N1CCCc1ccc(s1)C(O)=O
Show InChI InChI=1S/C26H33NO4S/c1-19(7-5-10-20-8-3-2-4-9-20)23(28)15-12-21-13-17-25(29)27(21)18-6-11-22-14-16-24(32-22)26(30)31/h2-4,8-9,12,14-16,19,21,23,28H,5-7,10-11,13,17-18H2,1H3,(H,30,31)/b15-12+/t19?,21-,23-/m0/s1
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n/an/an/an/a 2.28E+3n/an/an/an/a



CAYMAN CHEMICAL COMPANY, INC.

US Patent


Assay Description
1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 μl of reduced serum medium containing 0.5% FBS. Place ...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM179991
PNG
(US9676712, 4C)
Show SMILES CC(CCCc1ccccc1)[C@@H](O)\C=C\[C@H]1CCC(=O)N1CCCc1ccc(s1)C(O)=O
Show InChI InChI=1S/C26H33NO4S/c1-19(7-5-10-20-8-3-2-4-9-20)23(28)15-12-21-13-17-25(29)27(21)18-6-11-22-14-16-24(32-22)26(30)31/h2-4,8-9,12,14-16,19,21,23,28H,5-7,10-11,13,17-18H2,1H3,(H,30,31)/b15-12+/t19?,21-,23-/m0/s1
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n/an/an/an/a 0n/an/an/an/a



CAYMAN CHEMICAL COMPANY, INC.

US Patent


Assay Description
1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 μl of reduced serum medium containing 0.5% FBS. Place ...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM179986
PNG
(US9676712, 3C)
Show SMILES CC(CCCc1ccccc1)[C@@H](O)\C=C\[C@H]1CCC(=O)N1CC#Cc1ccc(s1)C(O)=O
Show InChI InChI=1S/C26H29NO4S/c1-19(7-5-10-20-8-3-2-4-9-20)23(28)15-12-21-13-17-25(29)27(21)18-6-11-22-14-16-24(32-22)26(30)31/h2-4,8-9,12,14-16,19,21,23,28H,5,7,10,13,17-18H2,1H3,(H,30,31)/b15-12+/t19?,21-,23-/m0/s1
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n/an/an/an/a 0.0190n/an/an/an/a



CAYMAN CHEMICAL COMPANY, INC.

US Patent


Assay Description
1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 μl of reduced serum medium containing 0.5% FBS. Place ...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%