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Patent code US9676721

Compile Data Set for Download or QSAR
Found 112 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180912
PNG
(US9676721, 28 2-cyano-1-({4-[(3,4-difluorobenzene)...)
Show SMILES Fc1ccc(cc1F)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C20H15F2N5O2S/c21-18-6-5-17(11-19(18)22)30(28,29)16-3-1-14(2-4-16)12-25-20(26-13-23)27-15-7-9-24-10-8-15/h1-11H,12H2,(H2,24,25,26,27)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180918
PNG
(US9676721, 36 2-cyano-1-({4-[(3-fluoro-4-methoxybe...)
Show SMILES COc1ccc(cc1F)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H18FN5O3S/c1-30-20-7-6-18(12-19(20)22)31(28,29)17-4-2-15(3-5-17)13-25-21(26-14-23)27-16-8-10-24-11-9-16/h2-12H,13H2,1H3,(H2,24,25,26,27)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180928
PNG
(US9676721, 97 2-cyano-3-(pyridin-4-yl)-1-{[4-(quin...)
Show SMILES O=S(=O)(c1ccc(CNC(Nc2ccncc2)=NC#N)cc1)c1cnc2ccccc2c1
Show InChI InChI=1S/C23H18N6O2S/c24-16-28-23(29-19-9-11-25-12-10-19)27-14-17-5-7-20(8-6-17)32(30,31)21-13-18-3-1-2-4-22(18)26-15-21/h1-13,15H,14H2,(H2,25,27,28,29)
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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180915
PNG
(US9676721, 21 1-{2-[4-(benzenesulfonyl)phenyl]ethy...)
Show SMILES O=S(=O)(c1ccccc1)c1ccc(CCN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C21H19N5O2S/c22-16-25-21(26-18-11-13-23-14-12-18)24-15-10-17-6-8-20(9-7-17)29(27,28)19-4-2-1-3-5-19/h1-9,11-14H,10,15H2,(H2,23,24,25,26)
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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180067
PNG
(US9676721, 17 1-[(4-{[4-chloro-3-(trifluoromethyl)...)
Show SMILES FC(F)(F)c1cc(ccc1Cl)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H15ClF3N5O2S/c22-19-6-5-17(11-18(19)21(23,24)25)33(31,32)16-3-1-14(2-4-16)12-28-20(29-13-26)30-15-7-9-27-10-8-15/h1-11H,12H2,(H2,27,28,29,30)
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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180921
PNG
(US9676721, 79 2-cyano-1-{[4-(1-methyl-1H-indazole-...)
Show SMILES Cn1ncc2ccc(cc12)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C22H19N7O2S/c1-29-21-12-20(7-4-17(21)14-27-29)32(30,31)19-5-2-16(3-6-19)13-25-22(26-15-23)28-18-8-10-24-11-9-18/h2-12,14H,13H2,1H3,(H2,24,25,26,28)
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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180103
PNG
(US9676721, 32 2-cyano-1-({4-[(3,5-difluorobenzene)...)
Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C20H15F2N5O2S/c21-15-9-16(22)11-19(10-15)30(28,29)18-3-1-14(2-4-18)12-25-20(26-13-23)27-17-5-7-24-8-6-17/h1-11H,12H2,(H2,24,25,26,27)
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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM181033
PNG
(US9676721, 41 2-cyano-1-({4-[(3-methoxy-4-methylbe...)
Show SMILES COc1cc(ccc1C)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C22H21N5O3S/c1-16-3-6-20(13-21(16)30-2)31(28,29)19-7-4-17(5-8-19)14-25-22(26-15-23)27-18-9-11-24-12-10-18/h3-13H,14H2,1-2H3,(H2,24,25,26,27)
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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180064
PNG
(US9676721, 64 2-cyano-1-[(4-{[3-(dimethylsulfamoyl...)
Show SMILES CN(C)S(=O)(=O)c1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C22H22N6O4S2/c1-28(2)34(31,32)21-5-3-4-20(14-21)33(29,30)19-8-6-17(7-9-19)15-25-22(26-16-23)27-18-10-12-24-13-11-18/h3-14H,15H2,1-2H3,(H2,24,25,26,27)
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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180081
PNG
(US9676721, 88 2-cyano-1-{[4-(6-methylpyridine-3-su...)
Show SMILES Cc1ccc(cn1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C20H18N6O2S/c1-15-2-5-19(13-23-15)29(27,28)18-6-3-16(4-7-18)12-24-20(25-14-21)26-17-8-10-22-11-9-17/h2-11,13H,12H2,1H3,(H2,22,24,25,26)
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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM181032
PNG
(US9676721, 75 2-cyano-1-[(4-{[4-(morpholin-4-yl)be...)
Show SMILES O=S(=O)(c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1)c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C24H24N6O3S/c25-18-28-24(29-20-9-11-26-12-10-20)27-17-19-1-5-22(6-2-19)34(31,32)23-7-3-21(4-8-23)30-13-15-33-16-14-30/h1-12H,13-17H2,(H2,26,27,28,29)
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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180272
PNG
(US9676721, 42 2-cyano-1-({4-[(3-methoxybenzene)sul...)
Show SMILES COc1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H19N5O3S/c1-29-18-3-2-4-20(13-18)30(27,28)19-7-5-16(6-8-19)14-24-21(25-15-22)26-17-9-11-23-12-10-17/h2-13H,14H2,1H3,(H2,23,24,25,26)
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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180257
PNG
(US9676721, 78 2-cyano-1-{[4-({3-[(morpholin-4-yl)c...)
Show SMILES O=C(N1CCOCC1)c1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C25H24N6O4S/c26-18-29-25(30-21-8-10-27-11-9-21)28-17-19-4-6-22(7-5-19)36(33,34)23-3-1-2-20(16-23)24(32)31-12-14-35-15-13-31/h1-11,16H,12-15,17H2,(H2,27,28,29,30)
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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180786
PNG
(US9676721, 34 2-cyano-1-({4-[(3-cyanobenzene)sulfo...)
Show SMILES O=S(=O)(c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1)c1cccc(c1)C#N
Show InChI InChI=1S/C21H16N6O2S/c22-13-17-2-1-3-20(12-17)30(28,29)19-6-4-16(5-7-19)14-25-21(26-15-23)27-18-8-10-24-11-9-18/h1-12H,14H2,(H2,24,25,26,27)
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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180095
PNG
(US9676721, 27 2-cyano-1-({4-[(3,4-dichlorobenzene)...)
Show SMILES Clc1ccc(cc1Cl)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C20H15Cl2N5O2S/c21-18-6-5-17(11-19(18)22)30(28,29)16-3-1-14(2-4-16)12-25-20(26-13-23)27-15-7-9-24-10-8-15/h1-11H,12H2,(H2,24,25,26,27)
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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180920
PNG
(US9676721, 39 2-cyano-1-({4-[(3-fluoro-5-methylben...)
Show SMILES Cc1cc(F)cc(c1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C21H18FN5O2S/c1-15-10-17(22)12-20(11-15)30(28,29)19-4-2-16(3-5-19)13-25-21(26-14-23)27-18-6-8-24-9-7-18/h2-12H,13H2,1H3,(H2,24,25,26,27)
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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180049
PNG
(US9676721, 65 2-cyano-1-[(4-{[3-(ethanesulfonyl)be...)
Show SMILES CCS(=O)(=O)c1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C22H21N5O4S2/c1-2-32(28,29)20-4-3-5-21(14-20)33(30,31)19-8-6-17(7-9-19)15-25-22(26-16-23)27-18-10-12-24-13-11-18/h3-14H,2,15H2,1H3,(H2,24,25,26,27)
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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180101
PNG
(US9676721, 20 1-{[4-(2H-1,3-benzodioxole-5-sulfony...)
Show SMILES O=S(=O)(c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1)c1ccc2OCOc2c1
Show InChI InChI=1S/C21H17N5O4S/c22-13-25-21(26-16-7-9-23-10-8-16)24-12-15-1-3-17(4-2-15)31(27,28)18-5-6-19-20(11-18)30-14-29-19/h1-11H,12,14H2,(H2,23,24,25,26)
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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180089
PNG
(US9676721, 57 2-cyano-1-({4-[6-(morpholin-4-yl)pyr...)
Show SMILES O=S(=O)(c1ccc(CNC(Nc2ccncc2)=NC#N)cc1)c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C23H23N7O3S/c24-17-28-23(29-19-7-9-25-10-8-19)27-15-18-1-3-20(4-2-18)34(31,32)21-5-6-22(26-16-21)30-11-13-33-14-12-30/h1-10,16H,11-15H2,(H2,25,27,28,29)
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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180260
PNG
(US9676721, 4 1-({4-[(3-chloro-4-methylbenzene)sulf...)
Show SMILES Cc1ccc(cc1Cl)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H18ClN5O2S/c1-15-2-5-19(12-20(15)22)30(28,29)18-6-3-16(4-7-18)13-25-21(26-14-23)27-17-8-10-24-11-9-17/h2-12H,13H2,1H3,(H2,24,25,26,27)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180253
PNG
(US9676721, 90 2-cyano-3-({4-[(4-fluorobenzene)sulf...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C20H16FN5O2S/c21-16-3-7-19(8-4-16)29(27,28)18-5-1-15(2-6-18)13-24-20(25-14-22)26-17-9-11-23-12-10-17/h1-12H,13H2,(H2,23,24,25,26)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM181671
PNG
(US9676721, 11 1-({4-[(4-chloro-3-fluorobenzene)sul...)
Show SMILES Fc1cc(ccc1Cl)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C20H15ClFN5O2S/c21-18-6-5-17(11-19(18)22)30(28,29)16-3-1-14(2-4-16)12-25-20(26-13-23)27-15-7-9-24-10-8-15/h1-11H,12H2,(H2,24,25,26,27)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM181022
PNG
(US9676721, 108 3-{[4-(benzenesulfonyl)phenyl]methy...)
Show SMILES O=S(=O)(c1ccccc1)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C20H17N5O2S/c21-15-24-20(25-17-10-12-22-13-11-17)23-14-16-6-8-19(9-7-16)28(26,27)18-4-2-1-3-5-18/h1-13H,14H2,(H2,22,23,24,25)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180854
PNG
(US9676721, 69 2-cyano-1-[(4-{[3-(propane-1-sulfona...)
Show SMILES CCCS(=O)(=O)Nc1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C23H24N6O4S2/c1-2-14-34(30,31)29-20-4-3-5-22(15-20)35(32,33)21-8-6-18(7-9-21)16-26-23(27-17-24)28-19-10-12-25-13-11-19/h3-13,15,29H,2,14,16H2,1H3,(H2,25,26,27,28)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM181024
PNG
(US9676721, 80 2-cyano-1-{[4-(1-methyl-1H-indole-2-...)
Show SMILES Cn1c(cc2ccccc12)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C23H20N6O2S/c1-29-21-5-3-2-4-18(21)14-22(29)32(30,31)20-8-6-17(7-9-20)15-26-23(27-16-24)28-19-10-12-25-13-11-19/h2-14H,15H2,1H3,(H2,25,26,27,28)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180083
PNG
(US9676721, 30 2-cyano-1-({4-[(3,4-dimethylbenzene)...)
Show SMILES Cc1ccc(cc1C)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C22H21N5O2S/c1-16-3-6-21(13-17(16)2)30(28,29)20-7-4-18(5-8-20)14-25-22(26-15-23)27-19-9-11-24-12-10-19/h3-13H,14H2,1-2H3,(H2,24,25,26,27)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180868
PNG
(US9676721, 106 3-[(4-{[2-cyano-3-(pyridin-4-yl)car...)
Show SMILES O=C(NC1CC1)c1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C24H22N6O3S/c25-16-28-24(30-20-10-12-26-13-11-20)27-15-17-4-8-21(9-5-17)34(32,33)22-3-1-2-18(14-22)23(31)29-19-6-7-19/h1-5,8-14,19H,6-7,15H2,(H,29,31)(H2,26,27,28,30)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180255
PNG
(US9676721, 38 2-cyano-1-({4-[(3-fluoro-5-methoxybe...)
Show SMILES COc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H18FN5O3S/c1-30-18-10-16(22)11-20(12-18)31(28,29)19-4-2-15(3-5-19)13-25-21(26-14-23)27-17-6-8-24-9-7-17/h2-12H,13H2,1H3,(H2,24,25,26,27)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180122
PNG
(US9676721, 85 2-cyano-1-{[4-(4-methylpyridine-3-su...)
Show SMILES Cc1ccncc1S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C20H18N6O2S/c1-15-6-9-23-13-19(15)29(27,28)18-4-2-16(3-5-18)12-24-20(25-14-21)26-17-7-10-22-11-8-17/h2-11,13H,12H2,1H3,(H2,22,24,25,26)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM181669
PNG
(US9676721, 23 2-cyano-1-({4-[(2,4-dimethylbenzene)...)
Show SMILES Cc1ccc(c(C)c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C22H21N5O2S/c1-16-3-8-21(17(2)13-16)30(28,29)20-6-4-18(5-7-20)14-25-22(26-15-23)27-19-9-11-24-12-10-19/h3-13H,14H2,1-2H3,(H2,24,25,26,27)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180922
PNG
(US9676721, 53 2-cyano-1-({4-[(4-methylbenzene)sulf...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C21H19N5O2S/c1-16-2-6-19(7-3-16)29(27,28)20-8-4-17(5-9-20)14-24-21(25-15-22)26-18-10-12-23-13-11-18/h2-13H,14H2,1H3,(H2,23,24,25,26)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM181031
PNG
(US9676721, 92 2-cyano-3-(pyridin-4-yl)-1-[(4-{[3-(...)
Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C21H16F3N5O2S/c22-21(23,24)16-2-1-3-19(12-16)32(30,31)18-6-4-15(5-7-18)13-27-20(28-14-25)29-17-8-10-26-11-9-17/h1-12H,13H2,(H2,26,27,28,29)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180065
PNG
(US9676721, 1 (E)-3-({4-[(3-chlorobenzene)sulfonyl]...)
Show SMILES Clc1cccc(c1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C20H16ClN5O2S/c21-16-2-1-3-19(12-16)29(27,28)18-6-4-15(5-7-18)13-24-20(25-14-22)26-17-8-10-23-11-9-17/h1-12H,13H2,(H2,23,24,25,26)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180919
PNG
(US9676721, 109 3-chloro-5-[(4-{[2-cyano-3-(pyridin...)
Show SMILES O=S(=O)(c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C26H21N5O2S/c27-19-30-26(31-23-14-16-28-17-15-23)29-18-20-6-10-24(11-7-20)34(32,33)25-12-8-22(9-13-25)21-4-2-1-3-5-21/h1-17H,18H2,(H2,28,29,30,31)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180091
PNG
(US9676721, 3 1-({4-[(3-chloro-4-methoxybenzene)sul...)
Show SMILES COc1ccc(cc1Cl)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C21H18ClN5O3S/c1-30-20-7-6-18(12-19(20)22)31(28,29)17-4-2-15(3-5-17)13-25-21(26-14-23)27-16-8-10-24-11-9-16/h2-12H,13H2,1H3,(H2,24,25,26,27)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180094
PNG
(US9676721, 77 2-cyano-1-[(4-{[4-(propan-2-yloxy)be...)
Show SMILES CC(C)Oc1ccc(cc1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C23H23N5O3S/c1-17(2)31-20-5-9-22(10-6-20)32(29,30)21-7-3-18(4-8-21)15-26-23(27-16-24)28-19-11-13-25-14-12-19/h3-14,17H,15H2,1-2H3,(H2,25,26,27,28)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180092
PNG
(US9676721, 67 2-cyano-1-[(4-{[3-(propan-2-yl)benze...)
Show SMILES CC(C)c1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C23H23N5O2S/c1-17(2)19-4-3-5-22(14-19)31(29,30)21-8-6-18(7-9-21)15-26-23(27-16-24)28-20-10-12-25-13-11-20/h3-14,17H,15H2,1-2H3,(H2,25,26,27,28)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180102
PNG
(US9676721, 99 2-cyano-3-(pyridin-4-yl)-1-{[4-(quin...)
Show SMILES O=S(=O)(c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1)c1cccc2cccnc12
Show InChI InChI=1S/C23H18N6O2S/c24-16-28-23(29-19-10-13-25-14-11-19)27-15-17-6-8-20(9-7-17)32(30,31)21-5-1-3-18-4-2-12-26-22(18)21/h1-14H,15H2,(H2,25,27,28,29)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180917
PNG
(US9676721, 100 2-cyano-3-[(4-{8-oxa-3-azabicyclo[3...)
Show SMILES O=S(=O)(N1CC2CCC(C1)O2)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C20H22N6O3S/c21-14-24-20(25-16-7-9-22-10-8-16)23-11-15-1-5-19(6-2-15)30(27,28)26-12-17-3-4-18(13-26)29-17/h1-2,5-10,17-18H,3-4,11-13H2,(H2,22,23,24,25)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180259
PNG
(US9676721, 10 1-({4-[(4-chloro-2-methoxybenzene)su...)
Show SMILES COc1cc(Cl)ccc1S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H18ClN5O3S/c1-30-19-12-16(22)4-7-20(19)31(28,29)18-5-2-15(3-6-18)13-25-21(26-14-23)27-17-8-10-24-11-9-17/h2-12H,13H2,1H3,(H2,24,25,26,27)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM181028
PNG
(US9676721, 63 2-cyano-1-[(4-{[3-(3,5-dimethyl-1H-p...)
Show SMILES Oc1cc(O)n(n1)-c1cccc(c1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C23H19N7O4S/c24-15-27-23(28-17-8-10-25-11-9-17)26-14-16-4-6-19(7-5-16)35(33,34)20-3-1-2-18(12-20)30-22(32)13-21(31)29-30/h1-13,32H,14H2,(H,29,31)(H2,25,26,27,28)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180258
PNG
(US9676721, 49 2-cyano-1-({4-[(4-fluoro-3-methylben...)
Show SMILES Cc1cc(ccc1F)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H18FN5O2S/c1-15-12-19(6-7-20(15)22)30(28,29)18-4-2-16(3-5-18)13-25-21(26-14-23)27-17-8-10-24-11-9-17/h2-12H,13H2,1H3,(H2,24,25,26,27)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180927
PNG
(US9676721, 40 2-cyano-1-({4-[(3-fluorobenzene)sulf...)
Show SMILES Fc1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C20H16FN5O2S/c21-16-2-1-3-19(12-16)29(27,28)18-6-4-15(5-7-18)13-24-20(25-14-22)26-17-8-10-23-11-9-17/h1-12H,13H2,(H2,23,24,25,26)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180126
PNG
(US9676721, 68 2-cyano-1-[(4-{[3-(propan-2-yloxy)be...)
Show SMILES CC(C)Oc1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C23H23N5O3S/c1-17(2)31-20-4-3-5-22(14-20)32(29,30)21-8-6-18(7-9-21)15-26-23(27-16-24)28-19-10-12-25-13-11-19/h3-14,17H,15H2,1-2H3,(H2,25,26,27,28)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180256
PNG
(US9676721, 33 2-cyano-1-({4-[(3,5-dimethylbenzene)...)
Show SMILES Cc1cc(C)cc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C22H21N5O2S/c1-16-11-17(2)13-21(12-16)30(28,29)20-5-3-18(4-6-20)14-25-22(26-15-23)27-19-7-9-24-10-8-19/h3-13H,14H2,1-2H3,(H2,24,25,26,27)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180254
PNG
(US9676721, 8 1-({4-[(3-chloro-5-methylbenzene)sulf...)
Show SMILES Cc1cc(Cl)cc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H18ClN5O2S/c1-15-10-17(22)12-20(11-15)30(28,29)19-4-2-16(3-5-19)13-25-21(26-14-23)27-18-6-8-24-9-7-18/h2-12H,13H2,1H3,(H2,24,25,26,27)
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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180252
PNG
(US9676721, 74 2-cyano-1-[(4-{[4-(1H-pyrazol-1-yl)b...)
Show SMILES O=S(=O)(c1ccc(CNC(Nc2ccncc2)=NC#N)cc1)c1ccc(cc1)-n1cccn1
Show InChI InChI=1S/C23H19N7O2S/c24-17-27-23(29-19-10-13-25-14-11-19)26-16-18-2-6-21(7-3-18)33(31,32)22-8-4-20(5-9-22)30-15-1-12-28-30/h1-15H,16H2,(H2,25,26,27,29)
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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM181670
PNG
(US9676721, 16 1-[(4-{[3-chloro-5-(trifluoromethyl)...)
Show SMILES FC(F)(F)c1cc(Cl)cc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H15ClF3N5O2S/c22-16-9-15(21(23,24)25)10-19(11-16)33(31,32)18-3-1-14(2-4-18)12-28-20(29-13-26)30-17-5-7-27-8-6-17/h1-11H,12H2,(H2,27,28,29,30)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180106
PNG
(US9676721, 15 1-({4-[3-chloro-2-(morpholin-4-yl)py...)
Show SMILES Clc1c(ccnc1N1CCOCC1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C23H22ClN7O3S/c24-21-20(7-10-27-22(21)31-11-13-34-14-12-31)35(32,33)19-3-1-17(2-4-19)15-28-23(29-16-25)30-18-5-8-26-9-6-18/h1-10H,11-15H2,(H2,26,28,29,30)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180123
PNG
(US9676721, 104 3-[(4-{[2-cyano-3-(pyridin-4-yl)car...)
Show SMILES CN(C)C(=O)c1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C23H22N6O3S/c1-29(2)22(30)18-4-3-5-21(14-18)33(31,32)20-8-6-17(7-9-20)15-26-23(27-16-24)28-19-10-12-25-13-11-19/h3-14H,15H2,1-2H3,(H2,25,26,27,28)
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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180919
PNG
(US9676721, 109 3-chloro-5-[(4-{[2-cyano-3-(pyridin...)
Show SMILES O=S(=O)(c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C26H21N5O2S/c27-19-30-26(31-23-14-16-28-17-15-23)29-18-20-6-10-24(11-7-20)34(32,33)25-12-8-22(9-13-25)21-4-2-1-3-5-21/h1-17H,18H2,(H2,28,29,30,31)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180085
PNG
(US9676721, 62 2-cyano-1-[(4-{[3-(1H-pyrazol-1-yl)b...)
Show SMILES O=S(=O)(c1ccc(CNC(Nc2ccncc2)=NC#N)cc1)c1cccc(c1)-n1cccn1
Show InChI InChI=1S/C23H19N7O2S/c24-17-27-23(29-19-9-12-25-13-10-19)26-16-18-5-7-21(8-6-18)33(31,32)22-4-1-3-20(15-22)30-14-2-11-28-30/h1-15H,16H2,(H2,25,26,27,29)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180275
PNG
(US9676721, 93 2-cyano-3-(pyridin-4-yl)-1-[(4-{[4-(...)
Show SMILES FC(F)(F)Oc1ccc(cc1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C21H16F3N5O3S/c22-21(23,24)32-17-3-7-19(8-4-17)33(30,31)18-5-1-15(2-6-18)13-27-20(28-14-25)29-16-9-11-26-12-10-16/h1-12H,13H2,(H2,26,27,28,29)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180910
PNG
(US9676721, 12 1-({4-[(4-chlorobenzene)sulfonyl]phe...)
Show SMILES Clc1ccc(cc1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C20H16ClN5O2S/c21-16-3-7-19(8-4-16)29(27,28)18-5-1-15(2-6-18)13-24-20(25-14-22)26-17-9-11-23-12-10-17/h1-12H,13H2,(H2,23,24,25,26)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180282
PNG
(US9676721, 89 2-cyano-1-{[4-(naphthalene-1-sulfony...)
Show SMILES O=S(=O)(c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1)c1cccc2ccccc12
Show InChI InChI=1S/C24H19N5O2S/c25-17-28-24(29-20-12-14-26-15-13-20)27-16-18-8-10-21(11-9-18)32(30,31)23-7-3-5-19-4-1-2-6-22(19)23/h1-15H,16H2,(H2,26,27,28,29)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180088
PNG
(US9676721, 76 2-cyano-1-[(4-{[4-(propan-2-yl)benze...)
Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C23H23N5O2S/c1-17(2)19-5-9-22(10-6-19)31(29,30)21-7-3-18(4-8-21)15-26-23(27-16-24)28-20-11-13-25-14-12-20/h3-14,17H,15H2,1-2H3,(H2,25,26,27,28)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180109
PNG
(US9676721, 29 2-cyano-1-({4-[(3,4-dimethoxybenzene...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C22H21N5O4S/c1-30-20-8-7-19(13-21(20)31-2)32(28,29)18-5-3-16(4-6-18)14-25-22(26-15-23)27-17-9-11-24-12-10-17/h3-13H,14H2,1-2H3,(H2,24,25,26,27)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM181036
PNG
(US9676721, 58 2-cyano-1-(pyridin-4-yl)-3-[(4-{[2-(...)
Show SMILES FC(F)(F)Oc1ccccc1S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C21H16F3N5O3S/c22-21(23,24)32-18-3-1-2-4-19(18)33(30,31)17-7-5-15(6-8-17)13-27-20(28-14-25)29-16-9-11-26-12-10-16/h1-12H,13H2,(H2,26,27,28,29)
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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180047
PNG
(US9676721, 22 2-cyano-1-({4-[(2,3-dimethylbenzene)...)
Show SMILES Cc1cccc(c1C)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C22H21N5O2S/c1-16-4-3-5-21(17(16)2)30(28,29)20-8-6-18(7-9-20)14-25-22(26-15-23)27-19-10-12-24-13-11-19/h3-13H,14H2,1-2H3,(H2,24,25,26,27)
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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180274
PNG
(US9676721, 82 2-cyano-1-{[4-(1-propyl-1H-pyrazole-...)
Show SMILES CCCn1cc(cn1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C20H21N7O2S/c1-2-11-27-14-19(13-25-27)30(28,29)18-5-3-16(4-6-18)12-23-20(24-15-21)26-17-7-9-22-10-8-17/h3-10,13-14H,2,11-12H2,1H3,(H2,22,23,24,26)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180913
PNG
(US9676721, 87 2-cyano-1-{[4-(5-methoxypyridine-3-s...)
Show SMILES COc1cncc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C20H18N6O3S/c1-29-17-10-19(13-23-12-17)30(27,28)18-4-2-15(3-5-18)11-24-20(25-14-21)26-16-6-8-22-9-7-16/h2-10,12-13H,11H2,1H3,(H2,22,24,25,26)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM181464
PNG
(US9676721, 102 3-[(4-{[2-cyano-3-(pyridin-4-yl)car...)
Show SMILES CC(C)NC(=O)c1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C24H24N6O3S/c1-17(2)29-23(31)19-4-3-5-22(14-19)34(32,33)21-8-6-18(7-9-21)15-27-24(28-16-25)30-20-10-12-26-13-11-20/h3-14,17H,15H2,1-2H3,(H,29,31)(H2,26,27,28,30)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180084
PNG
(US9676721, 81 2-cyano-1-{[4-(1-methyl-1H-pyrazole-...)
Show SMILES Cn1cc(cn1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C18H17N7O2S/c1-25-12-17(11-23-25)28(26,27)16-4-2-14(3-5-16)10-21-18(22-13-19)24-15-6-8-20-9-7-15/h2-9,11-12H,10H2,1H3,(H2,20,21,22,24)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180110
PNG
(US9676721, 35 2-cyano-1-({4-[(3-ethoxybenzene)sulf...)
Show SMILES CCOc1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C22H21N5O3S/c1-2-30-19-4-3-5-21(14-19)31(28,29)20-8-6-17(7-9-20)15-25-22(26-16-23)27-18-10-12-24-13-11-18/h3-14H,2,15H2,1H3,(H2,24,25,26,27)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180261
PNG
(US9676721, 55 2-cyano-1-({4-[(5-fluoro-2-methylben...)
Show SMILES Cc1ccc(F)cc1S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H18FN5O2S/c1-15-2-5-17(22)12-20(15)30(28,29)19-6-3-16(4-7-19)13-25-21(26-14-23)27-18-8-10-24-11-9-18/h2-12H,13H2,1H3,(H2,24,25,26,27)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180087
PNG
(US9676721, 50 2-cyano-1-({4-[(4-methanesulfonylben...)
Show SMILES CS(=O)(=O)c1ccc(cc1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H19N5O4S2/c1-31(27,28)18-6-8-20(9-7-18)32(29,30)19-4-2-16(3-5-19)14-24-21(25-15-22)26-17-10-12-23-13-11-17/h2-13H,14H2,1H3,(H2,23,24,25,26)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180877
PNG
(US9676721, 7 1-({4-[(3-chloro-5-methoxybenzene)sul...)
Show SMILES COc1cc(Cl)cc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H18ClN5O3S/c1-30-18-10-16(22)11-20(12-18)31(28,29)19-4-2-15(3-5-19)13-25-21(26-14-23)27-17-6-8-24-9-7-17/h2-12H,13H2,1H3,(H2,24,25,26,27)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180268
PNG
(US9676721, 101 3-[(4-{[2-cyano-3-(pyridin-4-yl)car...)
Show SMILES CN(C)C(=O)c1cc(F)cc(c1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C23H21FN6O3S/c1-30(2)22(31)17-11-18(24)13-21(12-17)34(32,33)20-5-3-16(4-6-20)14-27-23(28-15-25)29-19-7-9-26-10-8-19/h3-13H,14H2,1-2H3,(H2,26,27,28,29)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180276
PNG
(US9676721, 47 2-cyano-1-({4-[(4-ethylbenzene)sulfo...)
Show SMILES COc1ccc(cc1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C21H19N5O3S/c1-29-18-4-8-20(9-5-18)30(27,28)19-6-2-16(3-7-19)14-24-21(25-15-22)26-17-10-12-23-13-11-17/h2-13H,14H2,1H3,(H2,23,24,25,26)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180077
PNG
(US9676721, 84 2-cyano-1-{[4-(2-methylpyridine-3-su...)
Show SMILES Cc1ncccc1S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C20H18N6O2S/c1-15-19(3-2-10-23-15)29(27,28)18-6-4-16(5-7-18)13-24-20(25-14-21)26-17-8-11-22-12-9-17/h2-12H,13H2,1H3,(H2,22,24,25,26)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180264
PNG
(US9676721, 95 2-cyano-3-(pyridin-4-yl)-1-{[4-({4-[...)
Show SMILES O=C(N1CCCC1)c1ccc(cc1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C25H24N6O3S/c26-18-29-25(30-21-11-13-27-14-12-21)28-17-19-3-7-22(8-4-19)35(33,34)23-9-5-20(6-10-23)24(32)31-15-1-2-16-31/h3-14H,1-2,15-17H2,(H2,27,28,29,30)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180279
PNG
(US9676721, 5 1-({4-[(3-chloro-4-propoxybenzene)sul...)
Show SMILES CCCOc1ccc(cc1Cl)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C23H22ClN5O3S/c1-2-13-32-22-8-7-20(14-21(22)24)33(30,31)19-5-3-17(4-6-19)15-27-23(28-16-25)29-18-9-11-26-12-10-18/h3-12,14H,2,13,15H2,1H3,(H2,26,27,28,29)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180263
PNG
(US9676721, 14 1-({4-[(5-chloro-2-methoxybenzene)su...)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H18ClN5O3S/c1-30-19-7-4-16(22)12-20(19)31(28,29)18-5-2-15(3-6-18)13-25-21(26-14-23)27-17-8-10-24-11-9-17/h2-12H,13H2,1H3,(H2,24,25,26,27)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180129
PNG
(US9676721, 9 1-({4-[(4-acetylbenzene)sulfonyl]phen...)
Show SMILES CC(=O)c1ccc(cc1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C22H19N5O3S/c1-16(28)18-4-8-21(9-5-18)31(29,30)20-6-2-17(3-7-20)14-25-22(26-15-23)27-19-10-12-24-13-11-19/h2-13H,14H2,1H3,(H2,24,25,26,27)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180262
PNG
(US9676721, 19 1-{[4-(2H-1,3-benzodioxole-4-sulfony...)
Show SMILES O=S(=O)(c1ccc(CNC(Nc2ccncc2)=NC#N)cc1)c1cccc2OCOc12
Show InChI InChI=1S/C21H17N5O4S/c22-13-25-21(26-16-8-10-23-11-9-16)24-12-15-4-6-17(7-5-15)31(27,28)19-3-1-2-18-20(19)30-14-29-18/h1-11H,12,14H2,(H2,23,24,25,26)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180911
PNG
(US9676721, 6 1-({4-[(3-chloro-5-fluorobenzene)sulf...)
Show SMILES Fc1cc(Cl)cc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C20H15ClFN5O2S/c21-15-9-16(22)11-19(10-15)30(28,29)18-3-1-14(2-4-18)12-25-20(26-13-23)27-17-5-7-24-8-6-17/h1-11H,12H2,(H2,24,25,26,27)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180093
PNG
(US9676721, 71 2-cyano-1-[(4-{[3-fluoro-4-(2,2,2-tr...)
Show SMILES Fc1cc(ccc1OCC(F)(F)F)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C22H17F4N5O3S/c23-19-11-18(5-6-20(19)34-13-22(24,25)26)35(32,33)17-3-1-15(2-4-17)12-29-21(30-14-27)31-16-7-9-28-10-8-16/h1-11H,12-13H2,(H2,28,29,30,31)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180923
PNG
(US9676721, 86 2-cyano-1-{[4-(5-fluoropyridine-3-su...)
Show SMILES Fc1cncc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C19H15FN6O2S/c20-15-9-18(12-23-11-15)29(27,28)17-3-1-14(2-4-17)10-24-19(25-13-21)26-16-5-7-22-8-6-16/h1-9,11-12H,10H2,(H2,22,24,25,26)
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FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180924
PNG
(US9676721, 43 2-cyano-1-({4-[(3-methylbenzene)sulf...)
Show SMILES Cc1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H19N5O2S/c1-16-3-2-4-20(13-16)29(27,28)19-7-5-17(6-8-19)14-24-21(25-15-22)26-18-9-11-23-12-10-18/h2-13H,14H2,1H3,(H2,23,24,25,26)
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n/an/a 5.20n/an/an/an/an/an/a



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM181360
PNG
(US9676721, 72 2-cyano-1-[(4-{[3-fluoro-5-(2,2,2-tr...)
Show SMILES Fc1cc(OCC(F)(F)F)cc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C22H17F4N5O3S/c23-16-9-18(34-13-22(24,25)26)11-20(10-16)35(32,33)19-3-1-15(2-4-19)12-29-21(30-14-27)31-17-5-7-28-8-6-17/h1-11H,12-13H2,(H2,28,29,30,31)
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n/an/a 5.30n/an/an/an/an/an/a



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM181030
PNG
(US9676721, 61 2-cyano-1-[(4-{[2-methoxy-5-(propan-...)
Show SMILES COc1ccc(cc1S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1)C(C)C
Show InChI InChI=1S/C24H25N5O3S/c1-17(2)19-6-9-22(32-3)23(14-19)33(30,31)21-7-4-18(5-8-21)15-27-24(28-16-25)29-20-10-12-26-13-11-20/h4-14,17H,15H2,1-3H3,(H2,26,27,28,29)
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n/an/a 5.30n/an/an/an/an/an/a



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180107
PNG
(US9676721, 107 3-[(4-{[2-cyano-3-(pyridin-4-yl)car...)
Show SMILES CCNC(=O)c1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C23H22N6O3S/c1-2-26-22(30)18-4-3-5-21(14-18)33(31,32)20-8-6-17(7-9-20)15-27-23(28-16-24)29-19-10-12-25-13-11-19/h3-14H,2,15H2,1H3,(H,26,30)(H2,25,27,28,29)
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n/an/a 5.40n/an/an/an/an/an/a



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180127
PNG
(US9676721, 48 2-cyano-1-({4-[(4-fluoro-2-methylben...)
Show SMILES Cc1cc(F)ccc1S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H18FN5O2S/c1-15-12-17(22)4-7-20(15)30(28,29)19-5-2-16(3-6-19)13-25-21(26-14-23)27-18-8-10-24-11-9-18/h2-12H,13H2,1H3,(H2,24,25,26,27)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180266
PNG
(US9676721, 46 2-cyano-1-({4-[(4-ethoxybenzene)sulf...)
Show SMILES CCOc1ccc(cc1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C22H21N5O3S/c1-2-30-19-5-9-21(10-6-19)31(28,29)20-7-3-17(4-8-20)15-25-22(26-16-23)27-18-11-13-24-14-12-18/h3-14H,2,15H2,1H3,(H2,24,25,26,27)
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n/an/a 5.60n/an/an/an/an/an/a



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180098
PNG
(US9676721, 60 2-cyano-1-[(4-{[2-methoxy-4-(trifluo...)
Show SMILES COc1cc(ccc1S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1)C(F)(F)F
Show InChI InChI=1S/C22H18F3N5O3S/c1-33-19-12-16(22(23,24)25)4-7-20(19)34(31,32)18-5-2-15(3-6-18)13-28-21(29-14-26)30-17-8-10-27-11-9-17/h2-12H,13H2,1H3,(H2,27,28,29,30)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180250
PNG
(US9676721, 44 2-cyano-1-({4-[(4-cyanobenzene)sulfo...)
Show SMILES O=S(=O)(c1ccc(CNC(Nc2ccncc2)=NC#N)cc1)c1ccc(cc1)C#N
Show InChI InChI=1S/C21H16N6O2S/c22-13-16-1-5-19(6-2-16)30(28,29)20-7-3-17(4-8-20)14-25-21(26-15-23)27-18-9-11-24-12-10-18/h1-12H,14H2,(H2,24,25,26,27)
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n/an/a 5.90n/an/an/an/an/an/a



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM181459
PNG
(US9676721, 45 2-cyano-1-({4-[(4-ethoxy-3-fluoroben...)
Show SMILES CCOc1ccc(cc1F)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C22H20FN5O3S/c1-2-31-21-8-7-19(13-20(21)23)32(29,30)18-5-3-16(4-6-18)14-26-22(27-15-24)28-17-9-11-25-12-10-17/h3-13H,2,14H2,1H3,(H2,25,26,27,28)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180086
PNG
(US9676721, 73 2-cyano-1-[(4-{[3-fluoro-5-(trifluor...)
Show SMILES Fc1cc(cc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1)C(F)(F)F
Show InChI InChI=1S/C21H15F4N5O2S/c22-16-9-15(21(23,24)25)10-19(11-16)33(31,32)18-3-1-14(2-4-18)12-28-20(29-13-26)30-17-5-7-27-8-6-17/h1-11H,12H2,(H2,27,28,29,30)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180914
PNG
(US9676721, 70 2-cyano-1-[(4-{[3-fluoro-4-(1H-pyraz...)
Show SMILES Fc1cc(ccc1-n1cccn1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C23H18FN7O2S/c24-21-14-20(6-7-22(21)31-13-1-10-29-31)34(32,33)19-4-2-17(3-5-19)15-27-23(28-16-25)30-18-8-11-26-12-9-18/h1-14H,15H2,(H2,26,27,28,30)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180267
PNG
(US9676721, 91 2-cyano-3-(pyridin-4-yl)-1-[(4-{[3-(...)
Show SMILES FC(F)(F)Oc1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H16F3N5O3S/c22-21(23,24)32-17-2-1-3-19(12-17)33(30,31)18-6-4-15(5-7-18)13-27-20(28-14-25)29-16-8-10-26-11-9-16/h1-12H,13H2,(H2,26,27,28,29)
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n/an/a 6.20n/an/an/an/an/an/a



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180073
PNG
(US9676721, 98 2-cyano-3-(pyridin-4-yl)-1-{[4-(quin...)
Show SMILES O=S(=O)(c1ccc(CNC(Nc2ccncc2)=NC#N)cc1)c1ccc2ncccc2c1
Show InChI InChI=1S/C23H18N6O2S/c24-16-28-23(29-19-9-12-25-13-10-19)27-15-17-3-5-20(6-4-17)32(30,31)21-7-8-22-18(14-21)2-1-11-26-22/h1-14H,15H2,(H2,25,27,28,29)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM181021
PNG
(US9676721, 52 2-cyano-1-({4-[(4-methoxybenzene)sul...)
Show SMILES COc1ccc(cc1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C21H19N5O3S/c1-29-18-4-8-20(9-5-18)30(27,28)19-6-2-16(3-7-19)14-24-21(25-15-22)26-17-10-12-23-13-11-17/h2-13H,14H2,1H3,(H2,23,24,25,26)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180082
PNG
(US9676721, 110 4-[(4-{[2-cyano-3-(pyridin-4-yl)car...)
Show SMILES CCNC(=O)c1ccc(cc1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C23H22N6O3S/c1-2-26-22(30)18-5-9-21(10-6-18)33(31,32)20-7-3-17(4-8-20)15-27-23(28-16-24)29-19-11-13-25-14-12-19/h3-14H,2,15H2,1H3,(H,26,30)(H2,25,27,28,29)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180055
PNG
(US9676721, 112 5-[(4-{[2-cyano-3-(pyridin-4-yl)car...)
Show SMILES Cn1cc(ccc1C(N)=O)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180099
PNG
(US9676721, 105 3-[(4-{[2-cyano-3-(pyridin-4-yl)car...)
Show SMILES O=C(NC1CCCC1)c1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C26H26N6O3S/c27-18-30-26(32-22-12-14-28-15-13-22)29-17-19-8-10-23(11-9-19)36(34,35)24-7-3-4-20(16-24)25(33)31-21-5-1-2-6-21/h3-4,7-16,21H,1-2,5-6,17H2,(H,31,33)(H2,28,29,30,32)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180128
PNG
(US9676721, 83 2-cyano-1-{[4-(2,6-dimethoxypyridine...)
Show SMILES COc1ccc(c(OC)n1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H20N6O4S/c1-30-19-8-7-18(20(27-19)31-2)32(28,29)17-5-3-15(4-6-17)13-24-21(25-14-22)26-16-9-11-23-12-10-16/h3-12H,13H2,1-2H3,(H2,23,24,25,26)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180251
PNG
(US9676721, 24 2-cyano-1-({4-[(2-ethoxybenzene)sulf...)
Show SMILES CCOc1ccccc1S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C22H21N5O3S/c1-2-30-20-5-3-4-6-21(20)31(28,29)19-9-7-17(8-10-19)15-25-22(26-16-23)27-18-11-13-24-14-12-18/h3-14H,2,15H2,1H3,(H2,24,25,26,27)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180108
PNG
(US9676721, 25 2-cyano-1-({4-[(2-methoxybenzene)sul...)
Show SMILES COc1ccccc1S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C21H19N5O3S/c1-29-19-4-2-3-5-20(19)30(27,28)18-8-6-16(7-9-18)14-24-21(25-15-22)26-17-10-12-23-13-11-17/h2-13H,14H2,1H3,(H2,23,24,25,26)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180925
PNG
(US9676721, 66 2-cyano-1-[(4-{[3-(methoxymethyl)ben...)
Show SMILES COCc1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C22H21N5O3S/c1-30-15-18-3-2-4-21(13-18)31(28,29)20-7-5-17(6-8-20)14-25-22(26-16-23)27-19-9-11-24-12-10-19/h2-13H,14-15H2,1H3,(H2,24,25,26,27)
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n/an/a 7.20n/an/an/an/an/an/a



FORMA TM, LLC

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Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM181672
PNG
(US9676721, 26 2-cyano-1-({4-[(2-methylbenzene)sulf...)
Show SMILES Cc1ccccc1S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H19N5O2S/c1-16-4-2-3-5-20(16)29(27,28)19-8-6-17(7-9-19)14-24-21(25-15-22)26-18-10-12-23-13-11-18/h2-13H,14H2,1H3,(H2,23,24,25,26)
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n/an/a 7.90n/an/an/an/an/an/a



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180124
PNG
(US9676721, 56 2-cyano-1-({4-[2-(dimethylamino)pyri...)
Show SMILES CN(C)c1ncc(cn1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C20H20N8O2S/c1-28(2)20-24-12-18(13-25-20)31(29,30)17-5-3-15(4-6-17)11-23-19(26-14-21)27-16-7-9-22-10-8-16/h3-10,12-13H,11H2,1-2H3,(H2,22,23,26,27)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180125
PNG
(US9676721, 31 2-cyano-1-({4-[(3,5-dichlorobenzene)...)
Show SMILES Clc1cc(Cl)cc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C20H15Cl2N5O2S/c21-15-9-16(22)11-19(10-15)30(28,29)18-3-1-14(2-4-18)12-25-20(26-13-23)27-17-5-7-24-8-6-17/h1-11H,12H2,(H2,24,25,26,27)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180048
PNG
(US9676721, 59 2-cyano-1-[(4-{[2-(morpholin-4-ylmet...)
Show SMILES O=S(=O)(c1ccc(CNC(Nc2ccncc2)=NC#N)cc1)c1ccccc1CN1CCOCC1
Show InChI InChI=1S/C25H26N6O3S/c26-19-29-25(30-22-9-11-27-12-10-22)28-17-20-5-7-23(8-6-20)35(32,33)24-4-2-1-3-21(24)18-31-13-15-34-16-14-31/h1-12H,13-18H2,(H2,27,28,29,30)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180916
PNG
(US9676721, 37 2-cyano-1-({4-[(3-fluoro-4-methylben...)
Show SMILES Cc1ccc(cc1F)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H18FN5O2S/c1-15-2-5-19(12-20(15)22)30(28,29)18-6-3-16(4-7-18)13-25-21(26-14-23)27-17-8-10-24-11-9-17/h2-12H,13H2,1H3,(H2,24,25,26,27)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180926
PNG
(US9676721, 13 1-({4-[(5-acetyl-2-methoxybenzene)su...)
Show SMILES COc1ccc(cc1S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1)C(N)=O
Show InChI InChI=1S/C22H20N6O4S/c1-32-19-7-4-16(21(24)29)12-20(19)33(30,31)18-5-2-15(3-6-18)13-26-22(27-14-23)28-17-8-10-25-11-9-17/h2-12H,13H2,1H3,(H2,24,29)(H2,25,26,27,28)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180265
PNG
(US9676721, 94 2-cyano-3-(pyridin-4-yl)-1-[(4-{[4-(...)
Show SMILES FC(F)(F)c1ccc(cc1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C21H16F3N5O2S/c22-21(23,24)16-3-7-19(8-4-16)32(30,31)18-5-1-15(2-6-18)13-27-20(28-14-25)29-17-9-11-26-12-10-17/h1-12H,13H2,(H2,26,27,28,29)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180100
PNG
(US9676721, 2 (E)-3-{[4-(benzenesulfonyl)phenyl]met...)
Show SMILES O=S(=O)(c1ccccc1)c1ccc(CN\C(NCc2cccnc2)=N/C#N)cc1
Show InChI InChI=1S/C21H19N5O2S/c22-16-26-21(25-15-18-5-4-12-23-13-18)24-14-17-8-10-20(11-9-17)29(27,28)19-6-2-1-3-7-19/h1-13H,14-15H2,(H2,24,25,26)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180112
PNG
(US9676721, 103 3-[(4-{[2-cyano-3-(pyridin-4-yl)car...)
Show SMILES CCN(CC)C(=O)c1ccc(F)c(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C25H25FN6O3S/c1-3-32(4-2)24(33)19-7-10-22(26)23(15-19)36(34,35)21-8-5-18(6-9-21)16-29-25(30-17-27)31-20-11-13-28-14-12-20/h5-15H,3-4,16H2,1-2H3,(H2,28,29,30,31)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180277
PNG
(US9676721, 51 2-cyano-1-({4-[(4-methoxy-3-methylbe...)
Show SMILES COc1ccc(cc1C)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C22H21N5O3S/c1-16-13-20(7-8-21(16)30-2)31(28,29)19-5-3-17(4-6-19)14-25-22(26-15-23)27-18-9-11-24-12-10-18/h3-13H,14H2,1-2H3,(H2,24,25,26,27)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM181025
PNG
(US9676721, 96 2-cyano-3-(pyridin-4-yl)-1-{[4-(pyri...)
Show SMILES O=S(=O)(c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1)c1cccnc1
Show InChI InChI=1S/C19H16N6O2S/c20-14-24-19(25-16-7-10-21-11-8-16)23-12-15-3-5-17(6-4-15)28(26,27)18-2-1-9-22-13-18/h1-11,13H,12H2,(H2,21,23,24,25)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180072
PNG
(US9676721, 18 1-[4-(benzenesulfonyl)phenyl]-2-cyan...)
Show SMILES O=S(=O)(c1ccccc1)c1ccc(N\C(NCc2cccnc2)=N/C#N)cc1
Show InChI InChI=1S/C20H17N5O2S/c21-15-24-20(23-14-16-5-4-12-22-13-16)25-17-8-10-19(11-9-17)28(26,27)18-6-2-1-3-7-18/h1-13H,14H2,(H2,23,24,25)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180050
PNG
(US9676721, 111 2-cyano-1-(imidazol[1,2-a]pyridin-7...)
Show SMILES O=S(=O)(c1ccccc1)c1ccc(CN\C(NCc2ccn3ccnc3c2)=N/C#N)cc1
Show InChI InChI=1S/C23H20N6O2S/c24-17-28-23(27-16-19-10-12-29-13-11-25-22(29)14-19)26-15-18-6-8-21(9-7-18)32(30,31)20-4-2-1-3-5-20/h1-14H,15-16H2,(H2,26,27,28)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%