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Patent code US9676732

Compile Data Set for Download or QSAR
Found 74 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182871
PNG
(US9676732, 5 3-[2-Chloro-4-(2-phenylethynyl)phenyl...)
Show SMILES Cc1ccc2c(c1)n(C)c(=O)n(-c1ccc(cc1Cl)C#Cc1ccccc1)c2=O
Show InChI InChI=1S/C24H17ClN2O2/c1-16-8-12-19-22(14-16)26(2)24(29)27(23(19)28)21-13-11-18(15-20(21)25)10-9-17-6-4-3-5-7-17/h3-8,11-15H,1-2H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182892
PNG
(US9676732, 26 3-[2,6-Difluoro-4-(2-phenylethynyl)p...)
Show SMILES Cc1ccc2c(c1)n(C)c(=O)n(-c1c(F)cc(cc1F)C#Cc1ccccc1)c2=O
Show InChI InChI=1S/C24H16F2N2O2/c1-15-8-11-18-21(12-15)27(2)24(30)28(23(18)29)22-19(25)13-17(14-20(22)26)10-9-16-6-4-3-5-7-16/h3-8,11-14H,1-2H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182880
PNG
(US9676732, 14 3-[2-Chloro-4-(2-phenylethynyl)pheny...)
Show SMILES CCn1c2ccccc2c(=O)n(-c2ccc(cc2Cl)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C24H17ClN2O2/c1-2-26-21-11-7-6-10-19(21)23(28)27(24(26)29)22-15-14-18(16-20(22)25)13-12-17-8-4-3-5-9-17/h3-11,14-16H,2H2,1H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182883
PNG
(US9676732, 17 3-[2-Chloro-4-(2-phenylethynyl)pheny...)
Show SMILES Cn1c2ncncc2c(=O)n(-c2ccc(cc2Cl)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C21H13ClN4O2/c1-25-19-16(12-23-13-24-19)20(27)26(21(25)28)18-10-9-15(11-17(18)22)8-7-14-5-3-2-4-6-14/h2-6,9-13H,1H3
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HOFFMANN-LA ROCHE INC.

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Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182902
PNG
(US9676732, 36 6-[2,6-Difluoro-4-(2-phenylethynyl)p...)
Show SMILES CC(C)n1c2cnn(C)c2c(=O)n(-c2c(F)cc(cc2F)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C23H18F2N4O2/c1-14(2)28-19-13-26-27(3)21(19)22(30)29(23(28)31)20-17(24)11-16(12-18(20)25)10-9-15-7-5-4-6-8-15/h4-8,11-14H,1-3H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182905
PNG
(US9676732, 39 6-[2,6-Difluoro-4-(2-phenylethynyl)p...)
Show SMILES Cn1c2nsnc2c(=O)n(-c2c(F)cc(cc2F)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C19H10F2N4O2S/c1-24-17-15(22-28-23-17)18(26)25(19(24)27)16-13(20)9-12(10-14(16)21)8-7-11-5-3-2-4-6-11/h2-6,9-10H,1H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182909
PNG
(US9676732, 43 3-[2-Chloro-6-fluoro-4-[2-(3-pyridyl...)
Show SMILES Cc1cccc2c1n(C)c(=O)n(-c1c(F)cc(cc1Cl)C#Cc1cccnc1)c2=O
Show InChI InChI=1S/C23H15ClFN3O2/c1-14-5-3-7-17-20(14)27(2)23(30)28(22(17)29)21-18(24)11-16(12-19(21)25)9-8-15-6-4-10-26-13-15/h3-7,10-13H,1-2H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182912
PNG
(US9676732, 46 3-[3-Chloro-5-(2-phenylethynyl)-2-py...)
Show SMILES Cc1cccc2c1n(C)c(=O)n(-c1ncc(cc1Cl)C#Cc1ccccc1)c2=O
Show InChI InChI=1S/C23H16ClN3O2/c1-15-7-6-10-18-20(15)26(2)23(29)27(22(18)28)21-19(24)13-17(14-25-21)12-11-16-8-4-3-5-9-16/h3-10,13-14H,1-2H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182915
PNG
(US9676732, 49 3-[3-Fluoro-5-(2-phenylethynyl)-2-py...)
Show SMILES Cc1cccc2c1n(C)c(=O)n(-c1ncc(cc1F)C#Cc1ccccc1)c2=O
Show InChI InChI=1S/C23H16FN3O2/c1-15-7-6-10-18-20(15)26(2)23(29)27(22(18)28)21-19(24)13-17(14-25-21)12-11-16-8-4-3-5-9-16/h3-10,13-14H,1-2H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182927
PNG
(US9676732, 61 8-Chloro-3-[2,6-difluoro-4-(2-phenyl...)
Show SMILES Cn1c2c(Cl)ccnc2c(=O)n(-c2c(F)cc(cc2F)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C22H12ClF2N3O2/c1-27-19-15(23)9-10-26-18(19)21(29)28(22(27)30)20-16(24)11-14(12-17(20)25)8-7-13-5-3-2-4-6-13/h2-6,9-12H,1H3
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HOFFMANN-LA ROCHE INC.

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Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182935
PNG
(US9676732, 69 1-[2,6-Difluoro-4-(2-phenylethynyl)p...)
Show SMILES Cn1cnc2n(C)c(=O)n(-c3c(F)cc(cc3F)C#Cc3ccccc3)c(=O)c12
Show InChI InChI=1S/C21H14F2N4O2/c1-25-12-24-19-18(25)20(28)27(21(29)26(19)2)17-15(22)10-14(11-16(17)23)9-8-13-6-4-3-5-7-13/h3-7,10-12H,1-2H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182937
PNG
(US9676732, 71 3-[2-Chloro-6-fluoro-4-[2-(3-pyridyl...)
Show SMILES Fc1cc(cc(Cl)c1-n1c(=O)n(C2COC2)c2ccccc2c1=O)C#Cc1cccnc1
Show InChI InChI=1S/C24H15ClFN3O3/c25-19-10-16(8-7-15-4-3-9-27-12-15)11-20(26)22(19)29-23(30)18-5-1-2-6-21(18)28(24(29)31)17-13-32-14-17/h1-6,9-12,17H,13-14H2
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182870
PNG
(US9676732, 4 7-Chloro-3-[2-chloro-4-(2-phenylethyn...)
Show SMILES Cn1c2cc(Cl)ccc2c(=O)n(-c2ccc(cc2Cl)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C23H14Cl2N2O2/c1-26-21-14-17(24)10-11-18(21)22(28)27(23(26)29)20-12-9-16(13-19(20)25)8-7-15-5-3-2-4-6-15/h2-6,9-14H,1H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182891
PNG
(US9676732, 25 3-[2,6-Difluoro-4-(2-phenylethynyl)p...)
Show SMILES Cn1c2ncccc2c(=O)n(-c2c(F)cc(cc2F)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C22H13F2N3O2/c1-26-20-16(8-5-11-25-20)21(28)27(22(26)29)19-17(23)12-15(13-18(19)24)10-9-14-6-3-2-4-7-14/h2-8,11-13H,1H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182895
PNG
(US9676732, 29 2-(2,6-Difluoro-4-(phenylethynyl)phe...)
Show SMILES Fc1cc(cc(F)c1-n1c(=O)n2CCc3cccc(c23)c1=O)C#Cc1ccccc1
Show InChI InChI=1S/C24H14F2N2O2/c25-19-13-16(10-9-15-5-2-1-3-6-15)14-20(26)22(19)28-23(29)18-8-4-7-17-11-12-27(21(17)18)24(28)30/h1-8,13-14H,11-12H2
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182881
PNG
(US9676732, 15 3-[2-Chloro-4-(2-phenylethynyl)pheny...)
Show SMILES Cn1c2nccnc2c(=O)n(-c2ccc(cc2Cl)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C21H13ClN4O2/c1-25-19-18(23-11-12-24-19)20(27)26(21(25)28)17-10-9-15(13-16(17)22)8-7-14-5-3-2-4-6-14/h2-6,9-13H,1H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182884
PNG
(US9676732, 18 3-[2-Chloro-4-(2-phenylethynyl)pheny...)
Show SMILES Cn1c2ccc(F)cc2c(=O)n(-c2ccc(cc2Cl)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C23H14ClFN2O2/c1-26-20-12-10-17(25)14-18(20)22(28)27(23(26)29)21-11-9-16(13-19(21)24)8-7-15-5-3-2-4-6-15/h2-6,9-14H,1H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182907
PNG
(US9676732, 41 3-[2-Chloro-4-(2-phenylethynyl)pheny...)
Show SMILES Cc1cccc2n(C)c(=O)n(-c3ccc(cc3Cl)C#Cc3ccccc3)c(=O)c12
Show InChI InChI=1S/C24H17ClN2O2/c1-16-7-6-10-21-22(16)23(28)27(24(29)26(21)2)20-14-13-18(15-19(20)25)12-11-17-8-4-3-5-9-17/h3-10,13-15H,1-2H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182921
PNG
(US9676732, 55 1-Isopropyl-3-[5-(2-phenylethynyl)-2...)
Show SMILES CC(C)n1c2ccccc2c(=O)n(-c2ccc(cn2)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C24H19N3O2/c1-17(2)26-21-11-7-6-10-20(21)23(28)27(24(26)29)22-15-14-19(16-25-22)13-12-18-8-4-3-5-9-18/h3-11,14-17H,1-2H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182930
PNG
(US9676732, 64 5-[2,6-Difluoro-4-(2-phenylethynyl)p...)
Show SMILES CC(C)n1c2n[nH]cc2c(=O)n(-c2c(F)cc(cc2F)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C22H16F2N4O2/c1-13(2)27-20-16(12-25-26-20)21(29)28(22(27)30)19-17(23)10-15(11-18(19)24)9-8-14-6-4-3-5-7-14/h3-7,10-13H,1-2H3,(H,25,26)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182869
PNG
(US9676732, 3 8-Chloro-3-[2-chloro-4-(2-phenylethyn...)
Show SMILES Cn1c2c(Cl)cccc2c(=O)n(-c2ccc(cc2Cl)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C23H14Cl2N2O2/c1-26-21-17(8-5-9-18(21)24)22(28)27(23(26)29)20-13-12-16(14-19(20)25)11-10-15-6-3-2-4-7-15/h2-9,12-14H,1H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182872
PNG
(US9676732, 6 3-[2-Chloro-4-(2-phenylethynyl)phenyl...)
Show SMILES Clc1cc(ccc1-n1c(=O)[nH]c2ncccc2c1=O)C#Cc1ccccc1
Show InChI InChI=1S/C21H12ClN3O2/c22-17-13-15(9-8-14-5-2-1-3-6-14)10-11-18(17)25-20(26)16-7-4-12-23-19(16)24-21(25)27/h1-7,10-13H,(H,23,24,27)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182890
PNG
(US9676732, 24 3-[2,6-Difluoro-4-(2-phenylethynyl)p...)
Show SMILES Cc1cccc2c1n(C)c(=O)n(-c1c(F)cc(cc1F)C#Cc1ccccc1)c2=O
Show InChI InChI=1S/C24H16F2N2O2/c1-15-7-6-10-18-21(15)27(2)24(30)28(23(18)29)22-19(25)13-17(14-20(22)26)12-11-16-8-4-3-5-9-16/h3-10,13-14H,1-2H3
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HOFFMANN-LA ROCHE INC.

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Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182878
PNG
(US9676732, 12 2-(2-Chloro-4-(phenylethynyl)phenyl)...)
Show SMILES Clc1cc(ccc1-n1c(=O)n2CCc3cccc(c23)c1=O)C#Cc1ccccc1
Show InChI InChI=1S/C24H15ClN2O2/c25-20-15-17(10-9-16-5-2-1-3-6-16)11-12-21(20)27-23(28)19-8-4-7-18-13-14-26(22(18)19)24(27)29/h1-8,11-12,15H,13-14H2
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HOFFMANN-LA ROCHE INC.

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Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182886
PNG
(US9676732, 20 3-[2-Chloro-4-(2-phenylethynyl)pheny...)
Show SMILES Cc1csc2c1n(C)c(=O)n(-c1ccc(cc1Cl)C#Cc1ccccc1)c2=O
Show InChI InChI=1S/C22H15ClN2O2S/c1-14-13-28-20-19(14)24(2)22(27)25(21(20)26)18-11-10-16(12-17(18)23)9-8-15-6-4-3-5-7-15/h3-7,10-13H,1-2H3
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HOFFMANN-LA ROCHE INC.

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Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182897
PNG
(US9676732, 31 6-[2,6-Difluoro-4-(2-phenylethynyl)p...)
Show SMILES Fc1cc(cc(F)c1-n1c(=O)[nH]c2ncsc2c1=O)C#Cc1ccccc1
Show InChI InChI=1S/C19H9F2N3O2S/c20-13-8-12(7-6-11-4-2-1-3-5-11)9-14(21)15(13)24-18(25)16-17(22-10-27-16)23-19(24)26/h1-5,8-10H,(H,23,26)
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HOFFMANN-LA ROCHE INC.

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Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182898
PNG
(US9676732, 32 6-[2,6-Difluoro-4-(2-phenylethynyl)p...)
Show SMILES Cn1c2ncsc2c(=O)n(-c2c(F)cc(cc2F)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C20H11F2N3O2S/c1-24-18-17(28-11-23-18)19(26)25(20(24)27)16-14(21)9-13(10-15(16)22)8-7-12-5-3-2-4-6-12/h2-6,9-11H,1H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182911
PNG
(US9676732, 45 3-[3-Chloro-5-(2-phenylethynyl)-2-py...)
Show SMILES CC(C)n1c2ccccc2c(=O)n(-c2ncc(cc2Cl)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C24H18ClN3O2/c1-16(2)27-21-11-7-6-10-19(21)23(29)28(24(27)30)22-20(25)14-18(15-26-22)13-12-17-8-4-3-5-9-17/h3-11,14-16H,1-2H3
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HOFFMANN-LA ROCHE INC.

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Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182914
PNG
(US9676732, 48 1-Methyl-3-[5-(2-phenylethynyl)-3-(t...)
Show SMILES Cn1c2ccccc2c(=O)n(-c2ncc(cc2C(F)(F)F)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C23H14F3N3O2/c1-28-19-10-6-5-9-17(19)21(30)29(22(28)31)20-18(23(24,25)26)13-16(14-27-20)12-11-15-7-3-2-4-8-15/h2-10,13-14H,1H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182926
PNG
(US9676732, 60 6-[3-Chloro-5-(2-phenylethynyl)-2-py...)
Show SMILES CC(C)n1c2cn(C)nc2c(=O)n(-c2ncc(cc2Cl)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C22H18ClN5O2/c1-14(2)27-18-13-26(3)25-19(18)21(29)28(22(27)30)20-17(23)11-16(12-24-20)10-9-15-7-5-4-6-8-15/h4-8,11-14H,1-3H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182928
PNG
(US9676732, 62 5-[2,6-Difluoro-4-(2-phenylethynyl)p...)
Show SMILES Cn1cc2c(n1)n(C)c(=O)n(-c1c(F)cc(cc1F)C#Cc1ccccc1)c2=O
Show InChI InChI=1S/C21H14F2N4O2/c1-25-12-15-19(24-25)26(2)21(29)27(20(15)28)18-16(22)10-14(11-17(18)23)9-8-13-6-4-3-5-7-13/h3-7,10-12H,1-2H3
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HOFFMANN-LA ROCHE INC.

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Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182939
PNG
(US9676732, 73 3-[2,6-Difluoro-4-[2-(3-pyridyl)ethy...)
Show SMILES Cc1cccc2c1n(C)c(=O)n(-c1c(F)cc(cc1F)C#Cc1cccnc1)c2=O
Show InChI InChI=1S/C23H15F2N3O2/c1-14-5-3-7-17-20(14)27(2)23(30)28(22(17)29)21-18(24)11-16(12-19(21)25)9-8-15-6-4-10-26-13-15/h3-7,10-13H,1-2H3
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HOFFMANN-LA ROCHE INC.

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Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182873
PNG
(US9676732, 7 3-[2-Chloro-4-(2-phenylethynyl)phenyl...)
Show SMILES Cn1c2ncccc2c(=O)n(-c2ccc(cc2Cl)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C22H14ClN3O2/c1-25-20-17(8-5-13-24-20)21(27)26(22(25)28)19-12-11-16(14-18(19)23)10-9-15-6-3-2-4-7-15/h2-8,11-14H,1H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182888
PNG
(US9676732, 22 3-[2-Chloro-4-[2-(3-pyridyl)ethynyl]...)
Show SMILES CC(C)n1c2nccnc2c(=O)n(-c2ccc(cc2Cl)C#Cc2cccnc2)c1=O
Show InChI InChI=1S/C22H16ClN5O2/c1-14(2)27-20-19(25-10-11-26-20)21(29)28(22(27)30)18-8-7-15(12-17(18)23)5-6-16-4-3-9-24-13-16/h3-4,7-14H,1-2H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182893
PNG
(US9676732, 27 3-[2,6-Difluoro-4-(2-phenylethynyl)p...)
Show SMILES Cc1csc2c1n(C)c(=O)n(-c1c(F)cc(cc1F)C#Cc1ccccc1)c2=O
Show InChI InChI=1S/C22H14F2N2O2S/c1-13-12-29-20-18(13)25(2)22(28)26(21(20)27)19-16(23)10-15(11-17(19)24)9-8-14-6-4-3-5-7-14/h3-7,10-12H,1-2H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182879
PNG
(US9676732, 13 3-[2-Chloro-4-(2-phenylethynyl)pheny...)
Show SMILES CC(C)n1c2ccccc2c(=O)n(-c2ccc(cc2Cl)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C25H19ClN2O2/c1-17(2)27-22-11-7-6-10-20(22)24(29)28(25(27)30)23-15-14-19(16-21(23)26)13-12-18-8-4-3-5-9-18/h3-11,14-17H,1-2H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182885
PNG
(US9676732, 19 3-[2-Chloro-4-(2-phenylethynyl)pheny...)
Show SMILES Cn1c2c(F)c(F)ccc2c(=O)n(-c2ccc(cc2Cl)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C23H13ClF2N2O2/c1-27-21-16(10-11-18(25)20(21)26)22(29)28(23(27)30)19-12-9-15(13-17(19)24)8-7-14-5-3-2-4-6-14/h2-6,9-13H,1H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182901
PNG
(US9676732, 35 6-[2,6-Difluoro-4-(2-phenylethynyl)p...)
Show SMILES CC(C)n1c2cn(C)nc2c(=O)n(-c2c(F)cc(cc2F)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C23H18F2N4O2/c1-14(2)28-19-13-27(3)26-20(19)22(30)29(23(28)31)21-17(24)11-16(12-18(21)25)10-9-15-7-5-4-6-8-15/h4-8,11-14H,1-3H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182903
PNG
(US9676732, 37 3-[2,6-Difluoro-4-(2-phenylethynyl)p...)
Show SMILES CC(C)n1c2ncccc2c(=O)n(-c2c(F)cc(cc2F)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C24H17F2N3O2/c1-15(2)28-22-18(9-6-12-27-22)23(30)29(24(28)31)21-19(25)13-17(14-20(21)26)11-10-16-7-4-3-5-8-16/h3-9,12-15H,1-2H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182908
PNG
(US9676732, 42 3-[2-Chloro-6-fluoro-4-[2-(3-pyridyl...)
Show SMILES CC(C)n1c2ccccc2c(=O)n(-c2c(F)cc(cc2Cl)C#Cc2cccnc2)c1=O
Show InChI InChI=1S/C24H17ClFN3O2/c1-15(2)28-21-8-4-3-7-18(21)23(30)29(24(28)31)22-19(25)12-17(13-20(22)26)10-9-16-6-5-11-27-14-16/h3-8,11-15H,1-2H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182913
PNG
(US9676732, 47 2-(3-Chloro-5-(phenylethynyl)pyridin...)
Show SMILES Clc1cc(cnc1-n1c(=O)n2CCc3cccc(c23)c1=O)C#Cc1ccccc1
Show InChI InChI=1S/C23H14ClN3O2/c24-19-13-16(10-9-15-5-2-1-3-6-15)14-25-21(19)27-22(28)18-8-4-7-17-11-12-26(20(17)18)23(27)29/h1-8,13-14H,11-12H2
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182916
PNG
(US9676732, 50 3-[2-(Chloro-4-(2-phenylethynyl)phen...)
Show SMILES COCCn1c2ccccc2c(=O)n(-c2ncc(cc2Cl)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C24H18ClN3O3/c1-31-14-13-27-21-10-6-5-9-19(21)23(29)28(24(27)30)22-20(25)15-18(16-26-22)12-11-17-7-3-2-4-8-17/h2-10,15-16H,13-14H2,1H3
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HOFFMANN-LA ROCHE INC.

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Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182922
PNG
(US9676732, 56 6-[3-Fluoro-5-(2-phenylethynyl)-2-py...)
Show SMILES CC(C)n1c2cn(C)nc2c(=O)n(-c2ncc(cc2F)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C22H18FN5O2/c1-14(2)27-18-13-26(3)25-19(18)21(29)28(22(27)30)20-17(23)11-16(12-24-20)10-9-15-7-5-4-6-8-15/h4-8,11-14H,1-3H3
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HOFFMANN-LA ROCHE INC.

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Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182923
PNG
(US9676732, 57 6-[2,6-Difluoro-4-[2-(3-pyridyl)ethy...)
Show SMILES CC(C)n1c2cn(C)nc2c(=O)n(-c2c(F)cc(cc2F)C#Cc2cccnc2)c1=O
Show InChI InChI=1S/C22H17F2N5O2/c1-13(2)28-18-12-27(3)26-19(18)21(30)29(22(28)31)20-16(23)9-15(10-17(20)24)7-6-14-5-4-8-25-11-14/h4-5,8-13H,1-3H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182933
PNG
(US9676732, 67 6-[2-(Chloro-4-(2-phenylethynyl)phen...)
Show SMILES Cn1c2scnc2c(=O)n(-c2ccc(cc2Cl)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C20H12ClN3O2S/c1-23-19-17(22-12-27-19)18(25)24(20(23)26)16-10-9-14(11-15(16)21)8-7-13-5-3-2-4-6-13/h2-6,9-12H,1H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


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More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182938
PNG
(US9676732, 72 3-[2-Fluoro-4-(2-phenylethynyl)-6-(t...)
Show SMILES CC(C)n1c2ccccc2c(=O)n(-c2c(F)cc(cc2C(F)(F)F)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C26H18F4N2O2/c1-16(2)31-22-11-7-6-10-19(22)24(33)32(25(31)34)23-20(26(28,29)30)14-18(15-21(23)27)13-12-17-8-4-3-5-9-17/h3-11,14-16H,1-2H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182940
PNG
(US9676732, 74 8-(2,2-Difluoroethoxy)-3-[2,6-difluo...)
Show SMILES Cn1c2c(OCC(F)F)cccc2c(=O)n(-c2c(F)cc(cc2F)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C25H16F4N2O3/c1-30-22-17(8-5-9-20(22)34-14-21(28)29)24(32)31(25(30)33)23-18(26)12-16(13-19(23)27)11-10-15-6-3-2-4-7-15/h2-9,12-13,21H,14H2,1H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182887
PNG
(US9676732, 21 3-[2-Chloro-4-(2-phenylethynyl)pheny...)
Show SMILES CC(C)n1c2nccnc2c(=O)n(-c2ccc(cc2Cl)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C23H17ClN4O2/c1-15(2)27-21-20(25-12-13-26-21)22(29)28(23(27)30)19-11-10-17(14-18(19)24)9-8-16-6-4-3-5-7-16/h3-7,10-15H,1-2H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182889
PNG
(US9676732, 23 3-[2,6-Difluoro-4-(2-phenylethynyl)p...)
Show SMILES Cn1c2ccccc2c(=O)n(-c2c(F)cc(cc2F)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C23H14F2N2O2/c1-26-20-10-6-5-9-17(20)22(28)27(23(26)29)21-18(24)13-16(14-19(21)25)12-11-15-7-3-2-4-8-15/h2-10,13-14H,1H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182896
PNG
(US9676732, 30 2-(2,6-Difluoro-4-(pyridin-3-ylethyn...)
Show SMILES Fc1cc(cc(F)c1-n1c(=O)n2CCc3cccc(c23)c1=O)C#Cc1cccnc1
Show InChI InChI=1S/C23H13F2N3O2/c24-18-11-15(7-6-14-3-2-9-26-13-14)12-19(25)21(18)28-22(29)17-5-1-4-16-8-10-27(20(16)17)23(28)30/h1-5,9,11-13H,8,10H2
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182877
PNG
(US9676732, 11 1-[2-Chloro-4-(2-phenylethynyl)pheny...)
Show SMILES Cn1cnc2n(C)c(=O)n(-c3ccc(cc3Cl)C#Cc3ccccc3)c(=O)c12
Show InChI InChI=1S/C21H15ClN4O2/c1-24-13-23-19-18(24)20(27)26(21(28)25(19)2)17-11-10-15(12-16(17)22)9-8-14-6-4-3-5-7-14/h3-7,10-13H,1-2H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182899
PNG
(US9676732, 33 6-[2,6-Difluoro-4-(2-phenylethynyl)p...)
Show SMILES Cn1cc2n(C)c(=O)n(-c3c(F)cc(cc3F)C#Cc3ccccc3)c(=O)c2n1
Show InChI InChI=1S/C21H14F2N4O2/c1-25-12-17-18(24-25)20(28)27(21(29)26(17)2)19-15(22)10-14(11-16(19)23)9-8-13-6-4-3-5-7-13/h3-7,10-12H,1-2H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182904
PNG
(US9676732, 38 3-[2,6-Difluoro-4-(2-phenylethynyl)p...)
Show SMILES Cc1ccnc2c1n(C)c(=O)n(-c1c(F)cc(cc1F)C#Cc1ccccc1)c2=O
Show InChI InChI=1S/C23H15F2N3O2/c1-14-10-11-26-19-20(14)27(2)23(30)28(22(19)29)21-17(24)12-16(13-18(21)25)9-8-15-6-4-3-5-7-15/h3-7,10-13H,1-2H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182924
PNG
(US9676732, 58 6-[2-Chloro-6-fluoro-4-[2-(3-pyridyl...)
Show SMILES CC(C)n1c2cn(C)nc2c(=O)n(-c2c(F)cc(cc2Cl)C#Cc2cccnc2)c1=O
Show InChI InChI=1S/C22H17ClFN5O2/c1-13(2)28-18-12-27(3)26-19(18)21(30)29(22(28)31)20-16(23)9-15(10-17(20)24)7-6-14-5-4-8-25-11-14/h4-5,8-13H,1-3H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182925
PNG
(US9676732, 59 6-[3-Chloro-5-[2-(3-pyridyl)ethynyl]...)
Show SMILES CC(C)n1c2cn(C)nc2c(=O)n(-c2ncc(cc2Cl)C#Cc2cccnc2)c1=O
Show InChI InChI=1S/C21H17ClN6O2/c1-13(2)27-17-12-26(3)25-18(17)20(29)28(21(27)30)19-16(22)9-15(11-24-19)7-6-14-5-4-8-23-10-14/h4-5,8-13H,1-3H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182931
PNG
(US9676732, 65 3-[2-Chloro-4-(2-phenylethynyl)pheny...)
Show SMILES COc1cccc2c1n(C)c(=O)n(-c1ccc(cc1Cl)C#Cc1ccccc1)c2=O
Show InChI InChI=1S/C24H17ClN2O3/c1-26-22-18(9-6-10-21(22)30-2)23(28)27(24(26)29)20-14-13-17(15-19(20)25)12-11-16-7-4-3-5-8-16/h3-10,13-15H,1-2H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182867
PNG
(US9676732, 1 3-[2-Chloro-4-(2-phenylethynyl)phenyl...)
Show SMILES Cn1c2ccccc2c(=O)n(-c2ccc(cc2Cl)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C23H15ClN2O2/c1-25-20-10-6-5-9-18(20)22(27)26(23(25)28)21-14-13-17(15-19(21)24)12-11-16-7-3-2-4-8-16/h2-10,13-15H,1H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182900
PNG
(US9676732, 34 6-[2,6-Difluoro-4-(2-phenylethynyl)p...)
Show SMILES Cn1ncc2n(C)c(=O)n(-c3c(F)cc(cc3F)C#Cc3ccccc3)c(=O)c12
Show InChI InChI=1S/C21H14F2N4O2/c1-25-17-12-24-26(2)19(17)20(28)27(21(25)29)18-15(22)10-14(11-16(18)23)9-8-13-6-4-3-5-7-13/h3-7,10-12H,1-2H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182906
PNG
(US9676732, 40 6-[2,6-Difluoro-4-(2-phenylethynyl)p...)
Show SMILES CC(C)n1c2nsnc2c(=O)n(-c2c(F)cc(cc2F)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C21H14F2N4O2S/c1-12(2)26-19-17(24-30-25-19)20(28)27(21(26)29)18-15(22)10-14(11-16(18)23)9-8-13-6-4-3-5-7-13/h3-7,10-12H,1-2H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182910
PNG
(US9676732, 44 3-[3-Chloro-5-(2-phenylethynyl)-2-py...)
Show SMILES Cn1c2ccccc2c(=O)n(-c2ncc(cc2Cl)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C22H14ClN3O2/c1-25-19-10-6-5-9-17(19)21(27)26(22(25)28)20-18(23)13-16(14-24-20)12-11-15-7-3-2-4-8-15/h2-10,13-14H,1H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182868
PNG
(US9676732, 2 3-[2-Chloro-4-(2-phenylethynyl)phenyl...)
Show SMILES Cc1cccc2c1n(C)c(=O)n(-c1ccc(cc1Cl)C#Cc1ccccc1)c2=O
Show InChI InChI=1S/C24H17ClN2O2/c1-16-7-6-10-19-22(16)26(2)24(29)27(23(19)28)21-14-13-18(15-20(21)25)12-11-17-8-4-3-5-9-17/h3-10,13-15H,1-2H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182918
PNG
(US9676732, 52 6-[2-Chloro-4-(2-phenylethynyl)pheny...)
Show SMILES Cn1c2ncsc2c(=O)n(-c2ccc(cc2Cl)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C20H12ClN3O2S/c1-23-18-17(27-12-22-18)19(25)24(20(23)26)16-10-9-14(11-15(16)21)8-7-13-5-3-2-4-6-13/h2-6,9-12H,1H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182919
PNG
(US9676732, 53 3-[2-Chloro-4-(2-phenylethynyl)pheny...)
Show SMILES Clc1cc(ccc1-n1c(=O)n(C2CCC2)c2ccccc2c1=O)C#Cc1ccccc1
Show InChI InChI=1S/C26H19ClN2O2/c27-22-17-19(14-13-18-7-2-1-3-8-18)15-16-24(22)29-25(30)21-11-4-5-12-23(21)28(26(29)31)20-9-6-10-20/h1-5,7-8,11-12,15-17,20H,6,9-10H2
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182934
PNG
(US9676732, 68 3-[2,6-Difluoro-4-(2-phenylethynyl)p...)
Show SMILES CC(C)n1c2nccnc2c(=O)n(-c2c(F)cc(cc2F)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C23H16F2N4O2/c1-14(2)28-21-19(26-10-11-27-21)22(30)29(23(28)31)20-17(24)12-16(13-18(20)25)9-8-15-6-4-3-5-7-15/h3-7,10-14H,1-2H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182936
PNG
(US9676732, 70 3-[2,6-Difluoro-4-(2-phenylethynyl)p...)
Show SMILES COc1cccc2c1n(C)c(=O)n(-c1c(F)cc(cc1F)C#Cc1ccccc1)c2=O
Show InChI InChI=1S/C24H16F2N2O3/c1-27-21-17(9-6-10-20(21)31-2)23(29)28(24(27)30)22-18(25)13-16(14-19(22)26)12-11-15-7-4-3-5-8-15/h3-10,13-14H,1-2H3
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HOFFMANN-LA ROCHE INC.

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Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182874
PNG
(US9676732, 8 3-[2-Chloro-4-(2-phenylethynyl)phenyl...)
Show SMILES CCc1cccc2c1n(C)c(=O)n(-c1ccc(cc1Cl)C#Cc1ccccc1)c2=O
Show InChI InChI=1S/C25H19ClN2O2/c1-3-19-10-7-11-20-23(19)27(2)25(30)28(24(20)29)22-15-14-18(16-21(22)26)13-12-17-8-5-4-6-9-17/h4-11,14-16H,3H2,1-2H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182894
PNG
(US9676732, 28 3-[2,6-Difluoro-4-[2-(3-pyridyl)ethy...)
Show SMILES Cc1csc2c1n(C)c(=O)n(-c1c(F)cc(cc1F)C#Cc1cccnc1)c2=O
Show InChI InChI=1S/C21H13F2N3O2S/c1-12-11-29-19-17(12)25(2)21(28)26(20(19)27)18-15(22)8-14(9-16(18)23)6-5-13-4-3-7-24-10-13/h3-4,7-11H,1-2H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182875
PNG
(US9676732, 9 3-[2-Chloro-4-(2-phenylethynyl)phenyl...)
Show SMILES Cn1c2cccnc2c(=O)n(-c2ccc(cc2Cl)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C22H14ClN3O2/c1-25-19-8-5-13-24-20(19)21(27)26(22(25)28)18-12-11-16(14-17(18)23)10-9-15-6-3-2-4-7-15/h2-8,11-14H,1H3
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n/an/an/an/a 308n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182876
PNG
(US9676732, 10 3-[2-Chloro-4-(2-phenylethynyl)pheny...)
Show SMILES Cn1c2ccncc2c(=O)n(-c2ccc(cc2Cl)C#Cc2ccccc2)c1=O
Show InChI InChI=1S/C22H14ClN3O2/c1-25-19-11-12-24-14-17(19)21(27)26(22(25)28)20-10-9-16(13-18(20)23)8-7-15-5-3-2-4-6-15/h2-6,9-14H,1H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182882
PNG
(US9676732, 16 3-[2-Chloro-4-(2-phenylethynyl)pheny...)
Show SMILES Clc1cc(ccc1-n1c(=O)[nH]c2ncncc2c1=O)C#Cc1ccccc1
Show InChI InChI=1S/C20H11ClN4O2/c21-16-10-14(7-6-13-4-2-1-3-5-13)8-9-17(16)25-19(26)15-11-22-12-23-18(15)24-20(25)27/h1-5,8-12H,(H,22,23,24,27)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182917
PNG
(US9676732, 51 6-[2-Chloro-4-(2-phenylethynyl)pheny...)
Show SMILES Cn1c2nc(sc2c(=O)n(-c2ccc(cc2Cl)C#Cc2ccccc2)c1=O)N1CCOCC1
Show InChI InChI=1S/C24H19ClN4O3S/c1-27-21-20(33-23(26-21)28-11-13-32-14-12-28)22(30)29(24(27)31)19-10-9-17(15-18(19)25)8-7-16-5-3-2-4-6-16/h2-6,9-10,15H,11-14H2,1H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182920
PNG
(US9676732, 54 3-[2-Chloro-4-(2-phenylethynyl)pheny...)
Show SMILES CC(C)c1cccc2c1n(C)c(=O)n(-c1ccc(cc1Cl)C#Cc1ccccc1)c2=O
Show InChI InChI=1S/C26H21ClN2O2/c1-17(2)20-10-7-11-21-24(20)28(3)26(31)29(25(21)30)23-15-14-19(16-22(23)27)13-12-18-8-5-4-6-9-18/h4-11,14-17H,1-3H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182929
PNG
(US9676732, 63 5-[2,6-Difluoro-4-(2-phenylethynyl)p...)
Show SMILES Cn1ncc2c1n(C)c(=O)n(-c1c(F)cc(cc1F)C#Cc1ccccc1)c2=O
Show InChI InChI=1S/C21H14F2N4O2/c1-25-19-15(12-24-26(19)2)20(28)27(21(25)29)18-16(22)10-14(11-17(18)23)9-8-13-6-4-3-5-7-13/h3-7,10-12H,1-2H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Homo sapiens (Human))
BDBM182932
PNG
(US9676732, 66 3-[2,6-Difluoro-4-(2-phenylethynyl)p...)
Show SMILES Fc1cc(cc(F)c1-n1c(=O)n(C2COC2)c2ccccc2c1=O)C#Cc1ccccc1
Show InChI InChI=1S/C25H16F2N2O3/c26-20-12-17(11-10-16-6-2-1-3-7-16)13-21(27)23(20)29-24(30)19-8-4-5-9-22(19)28(25(29)31)18-14-32-15-18/h1-9,12-13,18H,14-15H2
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
About 24 hrs before an experiment, 510^4 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded ...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%