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Patent code US9682141

Compile Data Set for Download or QSAR

Found 2516 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM136882
PNG
(US9682141, 374)
Show SMILES C[C@H]1CN(CCN1)c1cnc2ccc(-c3ccc4oc(N)nc4c3)c(C)c2n1
Show InChI InChI=1S/C16H18BrNO2/c17-12-2-1-11-10-15(14(18)13(11)9-12)3-5-16(6-4-15)19-7-8-20-16/h1-2,9,18H,3-8,10H2
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (p85α)


(Homo sapiens (Human))
BDBM136884
PNG
(US9682141, 376)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(nc2c1)N1CC[C@H](C1)N1CCOCC1
Show InChI InChI=1S/C19H21BrN2O2S/c1-12-16(25)22-19(21-12)15-10-14(20)3-2-13(15)11-17(19)4-6-18(7-5-17)23-8-9-24-18/h2-3,10H,4-9,11H2,1H3,(H,22,25)
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (human))
BDBM136906
PNG
(US9682141, 388)
Show SMILES CC1(C)CN(CCN1)C1CN(C1)c1cnc2ccc(cc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C16H20BrNO/c1-2-19-13-5-7-16(8-6-13)10-11-3-4-12(17)9-14(11)15(16)18/h3-4,9,13,18H,2,5-8,10H2,1H3/t13-,16-
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Intellikine LLC

US Patent


Assay Description
The kinase reaction is performed in a white 384 well microtitre plate. The total reaction volume is 20 ul per well and the reaction buffer compositio...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (p85α)


(Homo sapiens (Human))
BDBM138093
PNG
(US9682141, 400)
Show SMILES Nc1nc2cc(cnc2o1)-c1ccc2ncc(C(=O)N3CCOCC3)n2c1
Show InChI InChI=1S/C22H21F3N2O3/c1-13-7-16(14-9-26-27(10-14)20(2,11-28)12-29)19-15-5-3-4-6-17(15)21(30,18(19)8-13)22(23,24)25/h3-10,28-30H,11-12H2,1-2H3
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM138176
PNG
(US9682141, 417)
Show SMILES COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccc2ncc(C(=O)N3CCOCC3)n2c1
Show InChI InChI=1S/C12H13ClFN/c1-15-6-9-5-12(9,7-15)8-2-3-11(14)10(13)4-8/h2-4,9H,5-7H2,1H3/t9?,12-/m0/s1
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
PI3-kinase subunit gamma


(Homo sapiens (human))
BDBM138182
PNG
(US9682141, 421)
Show SMILES COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1)-c1ccc2ncc(C(=O)N3CCOCC3)n2c1
Show InChI InChI=1S/C12H14FN/c1-8-2-3-9(4-11(8)13)12-5-10(12)6-14-7-12/h2-4,10,14H,5-7H2,1H3
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (p85α)


(Homo sapiens (Human))
BDBM138183
PNG
(US9682141, 422)
Show SMILES COc1ncc(cc1NS(=O)(=O)c1ccccc1F)-c1ccc2ncc(C(=O)N3CCOCC3)n2c1
Show InChI InChI=1S/C12H14FN/c1-8-2-3-9(4-11(8)13)12-5-10(12)6-14-7-12/h2-4,10,14H,5-7H2,1H3/t10?,12-/m0/s1
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM138316
PNG
(US9682141, 436)
Show SMILES Nc1nc2cc(cc(F)c2o1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C21H22BrN3O2/c22-18-7-2-1-4-14(18)12-24-10-8-16(9-11-24)25-13-15-5-3-6-17(20(23)26)19(15)21(25)27/h1-7,16H,8-13H2,(H2,23,26)
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
PI3-kinase subunit gamma


(Homo sapiens (human))
BDBM139723
PNG
(US9682141, 451)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2ncc(C(=O)N3CCOCC3)n2c1
Show InChI InChI=1S/C7H13NO4S/c9-13-11-6-7(12-13)5-8-1-3-10-4-2-8/h7H,1-6H2/t7-,13?/m0/s1
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (p85α)


(Homo sapiens (Human))
BDBM139725
PNG
(US9682141, 452)
Show SMILES Fc1ccccc1S(=O)(=O)Nc1cc(cnc1Cl)-c1ccc2ncc(C(=O)N3CCOCC3)n2c1
Show InChI InChI=1S/C20H29N5O4/c1-12-8-24(9-13(2)29-12)10-14(26)11-28-16-5-4-15-17(18(16)27-3)23-20(21)25-7-6-22-19(15)25/h4-5,12-14,26H,6-11H2,1-3H3,(H2,21,23)/t12-,13+,14-/m1/s1
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
PI3-kinase subunit gamma


(Homo sapiens (human))
BDBM139753
PNG
(US9682141, 458)
Show SMILES Fc1cccc(c1)S(=O)(=O)Nc1cc(cnc1Cl)-c1ccc2ncc(C(=O)N3CCOCC3)n2c1
Show InChI InChI=1S/C25H30N6O5/c1-16-18(4-3-7-26-16)24(33)29-25-28-21-19(23-27-8-9-31(23)25)5-6-20(22(21)34-2)36-15-17(32)14-30-10-12-35-13-11-30/h3-7,17,32H,8-15H2,1-2H3,(H,28,29,33)/t17-/m0/s1
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
PI3-kinase subunit gamma


(Homo sapiens (human))
BDBM140977
PNG
(US9682141, 471)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(C(=O)N3CCC(F)(F)C3)n2c1
Show InChI InChI=1S/C19H15F2N5O2/c20-19(21)5-6-25(10-19)17(27)14-8-23-16-4-2-12(9-26(14)16)11-1-3-15-13(7-11)24-18(22)28-15/h1-4,7-9H,5-6,10H2,(H2,22,24)
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (p85α)


(Homo sapiens (Human))
BDBM140978
PNG
(US9682141, 472)
Show SMILES CN(C1CCOCC1)C(=O)c1cnc2ccc(cn12)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C21H21N5O3/c1-25(15-6-8-28-9-7-15)20(27)17-11-23-19-5-3-14(12-26(17)19)13-2-4-18-16(10-13)24-21(22)29-18/h2-5,10-12,15H,6-9H2,1H3,(H2,22,24)
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US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (p85α)


(Homo sapiens (Human))
BDBM140979
PNG
(US9682141, 473)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(C(=O)N3CC(F)(F)C3)n2c1
Show InChI InChI=1S/C18H13F2N5O2/c19-18(20)8-24(9-18)16(26)13-6-22-15-4-2-11(7-25(13)15)10-1-3-14-12(5-10)23-17(21)27-14/h1-7H,8-9H2,(H2,21,23)
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US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (p85α)


(Homo sapiens (Human))
BDBM126955
PNG
(US9682141, 173)
Show SMILES CC1CN(CCO1)c1cnc2ccc(cc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C20H19N5O2/c1-12-11-25(6-7-26-12)19-10-22-15-4-2-13(8-16(15)23-19)14-3-5-18-17(9-14)24-20(21)27-18/h2-5,8-10,12H,6-7,11H2,1H3,(H2,21,24)
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
PI3-kinase subunit gamma


(Homo sapiens (human))
BDBM126955
PNG
(US9682141, 173)
Show SMILES CC1CN(CCO1)c1cnc2ccc(cc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C20H19N5O2/c1-12-11-25(6-7-26-12)19-10-22-15-4-2-13(8-16(15)23-19)14-3-5-18-17(9-14)24-20(21)27-18/h2-5,8-10,12H,6-7,11H2,1H3,(H2,21,24)
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US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (p85α)


(Homo sapiens (Human))
BDBM126972
PNG
(US9682141, 177)
Show SMILES Cc1cn(cn1)-c1cnc2ccc(cc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C19H14N6O/c1-11-9-25(10-22-11)18-8-21-14-4-2-12(6-15(14)23-18)13-3-5-17-16(7-13)24-19(20)26-17/h2-10H,1H3,(H2,20,24)
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (p85α)


(Homo sapiens (Human))
BDBM126973
PNG
(US9682141, 178 | US9682141, 396)
Show SMILES C[C@H]1CN(CCN1)c1cnc2ccc(cc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C20H20N6O/c1-12-11-26(7-6-22-12)19-10-23-15-4-2-13(8-16(15)24-19)14-3-5-18-17(9-14)25-20(21)27-18/h2-5,8-10,12,22H,6-7,11H2,1H3,(H2,21,25)/t12-/m0/s1
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (p85α)


(Homo sapiens (Human))
BDBM141053
PNG
(US9682141, 480)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(C(=O)N3C4CCC3COC4)n2c1
Show InChI InChI=1S/C21H19N5O3/c22-21-24-16-7-12(1-5-18(16)29-21)13-2-6-19-23-8-17(25(19)9-13)20(27)26-14-3-4-15(26)11-28-10-14/h1-2,5-9,14-15H,3-4,10-11H2,(H2,22,24)
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US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
PI3-kinase subunit gamma


(Homo sapiens (human))
BDBM127065
PNG
(US9682141, 189)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(C(=O)NCCO)n2c1
Show InChI InChI=1S/C17H15N5O3/c18-17-21-12-7-10(1-3-14(12)25-17)11-2-4-15-20-8-13(22(15)9-11)16(24)19-5-6-23/h1-4,7-9,23H,5-6H2,(H2,18,21)(H,19,24)
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (p85α)


(Homo sapiens (Human))
BDBM127067
PNG
(US9682141, 191)
Show SMILES CC(C)(C)N1CCN(CC1)C(=O)c1cnc2ccc(cn12)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C23H26N6O2/c1-23(2,3)28-10-8-27(9-11-28)21(30)18-13-25-20-7-5-16(14-29(18)20)15-4-6-19-17(12-15)26-22(24)31-19/h4-7,12-14H,8-11H2,1-3H3,(H2,24,26)
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (p85α)


(Homo sapiens (Human))
BDBM127392
PNG
(US9682141, 197)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(C(=O)N3CCC3)n2c1
Show InChI InChI=1S/C18H15N5O2/c19-18-21-13-8-11(2-4-15(13)25-18)12-3-5-16-20-9-14(23(16)10-12)17(24)22-6-1-7-22/h2-5,8-10H,1,6-7H2,(H2,19,21)
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (p85α)


(Homo sapiens (Human))
BDBM127396
PNG
(US9682141, 199)
Show SMILES CS(=O)(=O)CCN1CCC(CC1)NC(=O)c1cnc2ccc(cn12)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C23H26N6O4S/c1-34(31,32)11-10-28-8-6-17(7-9-28)26-22(30)19-13-25-21-5-3-16(14-29(19)21)15-2-4-20-18(12-15)27-23(24)33-20/h2-5,12-14,17H,6-11H2,1H3,(H2,24,27)(H,26,30)
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (p85α)


(Homo sapiens (Human))
BDBM127454
PNG
(US9682141, 201)
Show SMILES CC1CN(CCO1)C(=O)c1cnc2ccc(cn12)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C20H19N5O3/c1-12-10-24(6-7-27-12)19(26)16-9-22-18-5-3-14(11-25(16)18)13-2-4-17-15(8-13)23-20(21)28-17/h2-5,8-9,11-12H,6-7,10H2,1H3,(H2,21,23)
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (p85α)


(Homo sapiens (Human))
BDBM127456
PNG
(US9682141, 202)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(C(=O)N3CCC(O)C3)n2c1
Show InChI InChI=1S/C19H17N5O3/c20-19-22-14-7-11(1-3-16(14)27-19)12-2-4-17-21-8-15(24(17)9-12)18(26)23-6-5-13(25)10-23/h1-4,7-9,13,25H,5-6,10H2,(H2,20,22)
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (p85α)


(Homo sapiens (Human))
BDBM127466
PNG
(US9682141, 203)
Show SMILES CN1CCC(CC1)NC(=O)c1cnc2ccc(nn12)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C20H21N7O2/c1-26-8-6-13(7-9-26)23-19(28)16-11-22-18-5-3-14(25-27(16)18)12-2-4-17-15(10-12)24-20(21)29-17/h2-5,10-11,13H,6-9H2,1H3,(H2,21,24)(H,23,28)
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
PI3-kinase subunit gamma


(Homo sapiens (human))
BDBM127486
PNG
(US9682141, 207)
Show SMILES C[C@H](N)C(=O)N1CCN(CC1)c1cnc2ccc(cc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C22H23N7O2/c1-13(23)21(30)29-8-6-28(7-9-29)20-12-25-16-4-2-14(10-17(16)26-20)15-3-5-19-18(11-15)27-22(24)31-19/h2-5,10-13H,6-9,23H2,1H3,(H2,24,27)/t13-/m0/s1
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM127553
PNG
(US9682141, 214)
Show SMILES CNC(=O)C1CN(C1)c1cnc2ccc(cc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C20H18N6O2/c1-22-19(27)13-9-26(10-13)18-8-23-14-4-2-11(6-15(14)24-18)12-3-5-17-16(7-12)25-20(21)28-17/h2-8,13H,9-10H2,1H3,(H2,21,25)(H,22,27)
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM127830
PNG
(US9682141, 222)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(NCCCN3CCOCC3)nc2c1
Show InChI InChI=1S/C22H24N6O2/c23-22-27-19-13-16(3-5-20(19)30-22)15-2-4-17-18(12-15)26-21(14-25-17)24-6-1-7-28-8-10-29-11-9-28/h2-5,12-14H,1,6-11H2,(H2,23,27)(H,24,26)
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM141155
PNG
(US9682141, 521)
Show SMILES CC(C)N1CCC(CC1)n1cnc2ccc(cc2c1=O)-c1cnc(Cl)c(NS(=O)(=O)c2ccccc2)c1
Show InChI InChI=1S/C27H28ClN5O3S/c1-18(2)32-12-10-21(11-13-32)33-17-30-24-9-8-19(14-23(24)27(33)34)20-15-25(26(28)29-16-20)31-37(35,36)22-6-4-3-5-7-22/h3-9,14-18,21,31H,10-13H2,1-2H3
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
PI3-kinase subunit gamma


(Homo sapiens (human))
BDBM141157
PNG
(US9682141, 523)
Show SMILES CC(C)N1CCC(CC1)n1cnc2ccc(cc2c1=O)-c1cnc(Cl)c(NS(C)(=O)=O)c1
Show InChI InChI=1S/C22H26ClN5O3S/c1-14(2)27-8-6-17(7-9-27)28-13-25-19-5-4-15(10-18(19)22(28)29)16-11-20(21(23)24-12-16)26-32(3,30)31/h4-5,10-14,17,26H,6-9H2,1-3H3
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (p85α)


(Homo sapiens (Human))
BDBM141165
PNG
(US9682141, 525)
Show SMILES COc1ncc(cc1NS(C)(=O)=O)-c1ccc2ncn(C3CCN(C)CC3)c(=O)c2c1
Show InChI InChI=1S/C21H25N5O4S/c1-25-8-6-16(7-9-25)26-13-23-18-5-4-14(10-17(18)21(26)27)15-11-19(24-31(3,28)29)20(30-2)22-12-15/h4-5,10-13,16,24H,6-9H2,1-3H3
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
PI3-kinase subunit delta


(Homo sapiens (human))
BDBM141167
PNG
(US9682141, 527)
Show SMILES CN1CCC(CC1)n1cnc2ccc(cc2c1=O)-c1cnc(Cl)c(NS(=O)(=O)c2ccccc2)c1
Show InChI InChI=1S/C25H24ClN5O3S/c1-30-11-9-19(10-12-30)31-16-28-22-8-7-17(13-21(22)25(31)32)18-14-23(24(26)27-15-18)29-35(33,34)20-5-3-2-4-6-20/h2-8,13-16,19,29H,9-12H2,1H3
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
PI3-kinase subunit gamma


(Homo sapiens (human))
BDBM128825
PNG
(US9682141, 242)
Show SMILES CC(=O)Nc1nc2ccc(cc2s1)-c1ccc2nc(N)oc2c1
Show InChI InChI=1S/C16H12N4O2S/c1-8(21)18-16-20-12-5-3-10(7-14(12)23-16)9-2-4-11-13(6-9)22-15(17)19-11/h2-7H,1H3,(H2,17,19)(H,18,20,21)
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
PI3-kinase subunit gamma


(Homo sapiens (human))
BDBM141977
PNG
(US9682141, 548 | US9682141, 552)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(nc2n1)N1C2CCC1COC2
Show InChI InChI=1S/C20H18N6O2/c21-20-24-16-7-11(1-6-17(16)28-20)14-4-5-15-19(23-14)25-18(8-22-15)26-12-2-3-13(26)10-27-9-12/h1,4-8,12-13H,2-3,9-10H2,(H2,21,24)
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM129642
PNG
(US9682141, 249)
Show SMILES Nc1nc2ccc(cc2o1)-c1ccc2sc(N)nc2c1
Show InChI InChI=1S/C14H10N4OS/c15-13-17-9-3-1-8(6-11(9)19-13)7-2-4-12-10(5-7)18-14(16)20-12/h1-6H,(H2,15,17)(H2,16,18)
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (p85α)


(Homo sapiens (Human))
BDBM129990
PNG
(US9682141, 258)
Show SMILES NC(=O)[C@H]1CCCN1c1cnc2ccc(cc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C20H18N6O2/c21-19(27)16-2-1-7-26(16)18-10-23-13-5-3-11(8-14(13)24-18)12-4-6-17-15(9-12)25-20(22)28-17/h3-6,8-10,16H,1-2,7H2,(H2,21,27)(H2,22,25)/t16-/m1/s1
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
PI3-kinase subunit gamma


(Homo sapiens (human))
BDBM130245
PNG
(US9682141, 265)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(C(=O)N3CC[C@@H](O)C3)n2c1
Show InChI InChI=1S/C19H17N5O3/c20-19-22-14-7-11(1-3-16(14)27-19)12-2-4-17-21-8-15(24(17)9-12)18(26)23-6-5-13(25)10-23/h1-4,7-9,13,25H,5-6,10H2,(H2,20,22)/t13-/m1/s1
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (p85α)


(Homo sapiens (Human))
BDBM130246
PNG
(US9682141, 266)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(C(=O)N3CC(C3)N3CCOCC3)n2c1
Show InChI InChI=1S/C22H22N6O3/c23-22-25-17-9-14(1-3-19(17)31-22)15-2-4-20-24-10-18(28(20)11-15)21(29)27-12-16(13-27)26-5-7-30-8-6-26/h1-4,9-11,16H,5-8,12-13H2,(H2,23,25)
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US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (p85α)


(Homo sapiens (Human))
BDBM142033
PNG
(US9682141, 560 | US9682141, 568)
Show SMILES C[C@@H](N)C(=O)N1CCN(CC1)c1cnc2ccc(nc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C21H22N8O2/c1-12(22)20(30)29-8-6-28(7-9-29)18-11-24-15-4-3-14(25-19(15)27-18)13-2-5-17-16(10-13)26-21(23)31-17/h2-5,10-12H,6-9,22H2,1H3,(H2,23,26)/t12-/m1/s1
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US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (p85α)


(Homo sapiens (Human))
BDBM141191
PNG
(US9682141, 535 | US9682141, 565)
Show SMILES CCOC(=O)N1CCN(CC1)c1cnc2ccc(nc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C21H21N7O3/c1-2-30-21(29)28-9-7-27(8-10-28)18-12-23-15-5-4-14(24-19(15)26-18)13-3-6-17-16(11-13)25-20(22)31-17/h3-6,11-12H,2,7-10H2,1H3,(H2,22,25)
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US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (p85α)


(Homo sapiens (Human))
BDBM142736
PNG
(US9682141, 569 | US9682141, 572)
Show SMILES CC(C)(N)C(=O)N1CCN(CC1)c1cnc2ccc(nc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C22H24N8O2/c1-22(2,24)20(31)30-9-7-29(8-10-30)18-12-25-15-5-4-14(26-19(15)28-18)13-3-6-17-16(11-13)27-21(23)32-17/h3-6,11-12H,7-10,24H2,1-2H3,(H2,23,27)
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US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (p85α)


(Homo sapiens (Human))
BDBM134768
PNG
(US9682141, 277)
Show SMILES CN1CCN(CC1=O)c1cnc2ccc(cc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C24H21ClN6O3/c1-14(24(34)26-2)31-12-20(19-11-28-13-29-23(19)31)22(33)16-8-18(10-27-9-16)30-21(32)7-15-3-5-17(25)6-4-15/h3-6,8-14H,7H2,1-2H3,(H,26,34)(H,30,32)
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US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
PI3-kinase subunit gamma


(Homo sapiens (human))
BDBM142981
PNG
(US9682141, 574)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(nc2n1)N1CCC(O)CC1
Show InChI InChI=1S/C19H18N6O2/c20-19-23-15-9-11(1-4-16(15)27-19)13-2-3-14-18(22-13)24-17(10-21-14)25-7-5-12(26)6-8-25/h1-4,9-10,12,26H,5-8H2,(H2,20,23)
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n/an/a<100n/an/an/an/an/an/a



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (p85α)


(Homo sapiens (Human))
BDBM142985
PNG
(US9682141, 575)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(nc2n1)N1CC(C1)N1CCN(CCO)CC1
Show InChI InChI=1S/C23H26N8O2/c24-23-27-19-11-15(1-4-20(19)33-23)17-2-3-18-22(26-17)28-21(12-25-18)31-13-16(14-31)30-7-5-29(6-8-30)9-10-32/h1-4,11-12,16,32H,5-10,13-14H2,(H2,24,27)
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (p85α)


(Homo sapiens (Human))
BDBM142994
PNG
(US9682141, 579)
Show SMILES Cc1nccn1C1CN(C1)c1cnc2ccc(nc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C21H18N8O/c1-12-23-6-7-29(12)14-10-28(11-14)19-9-24-16-4-3-15(25-20(16)27-19)13-2-5-18-17(8-13)26-21(22)30-18/h2-9,14H,10-11H2,1H3,(H2,22,26)
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (p85α)


(Homo sapiens (Human))
BDBM143013
PNG
(US9682141, 584)
Show SMILES C[C@H]1CN(CCN1C)C1CN(C1)c1cnc2ccc(nc2c1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C24H27N7O/c1-15-12-30(8-7-29(15)2)18-13-31(14-18)17-10-21-20(26-11-17)5-4-19(27-21)16-3-6-23-22(9-16)28-24(25)32-23/h3-6,9-11,15,18H,7-8,12-14H2,1-2H3,(H2,25,28)/t15-/m0/s1
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (p85α)


(Homo sapiens (Human))
BDBM135655
PNG
(US9682141, 293)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(C(=O)NCCCN3CCCC3)n2c1
Show InChI InChI=1S/C48H68N16O11/c1-26(65)58-32(16-9-19-55-47(50)51)41(70)63-36-23-38(66)54-18-8-7-15-31(40(49)69)59-44(73)35(22-28-25-57-30-14-6-5-13-29(28)30)62-42(71)33(17-10-20-56-48(52)53)60-43(72)34(21-27-11-3-2-4-12-27)61-46(75)37(24-39(67)68)64-45(36)74/h2-6,11-14,25,31-37,57H,7-10,15-24H2,1H3,(H2,49,69)(H,54,66)(H,58,65)(H,59,73)(H,60,72)(H,61,75)(H,62,71)(H,63,70)(H,64,74)(H,67,68)(H4,50,51,55)(H4,52,53,56)/t31-,32-,33-,34+,35-,36-,37+/m0/s1
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
PI3-kinase subunit gamma


(Homo sapiens (human))
BDBM135657
PNG
(US9682141, 294)
Show SMILES Cc1ccc(NC(=O)c2cnc3ccc(cn23)-c2ccc3oc(N)nc3c2)cn1
Show InChI InChI=1S/C50H74N16O9/c1-28(2)23-37-45(72)64-38(24-30-13-5-4-6-14-30)46(73)62-36(19-12-22-58-50(54)55)44(71)65-39(25-31-27-59-33-16-8-7-15-32(31)33)47(74)61-34(42(51)69)17-9-10-20-56-41(68)26-40(48(75)63-37)66-43(70)35(60-29(3)67)18-11-21-57-49(52)53/h4-8,13-16,27-28,34-40,59H,9-12,17-26H2,1-3H3,(H2,51,69)(H,56,68)(H,60,67)(H,61,74)(H,62,73)(H,63,75)(H,64,72)(H,65,71)(H,66,70)(H4,52,53,57)(H4,54,55,58)/t34-,35-,36-,37+,38+,39-,40-/m0/s1
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (p85α)


(Homo sapiens (Human))
BDBM135661
PNG
(US9682141, 298)
Show SMILES N[C@@H](CO)C(=O)N1CCN(CC1)c1cnc2ccc(cc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C55H76N16O10/c1-32(81-31-35-17-7-4-8-18-35)46-53(80)70-42(27-34-15-5-3-6-16-34)50(77)67-41(23-14-26-63-55(59)60)49(76)68-43(28-36-30-64-38-20-10-9-19-37(36)38)51(78)66-39(47(56)74)21-11-12-24-61-45(73)29-44(52(79)71-46)69-48(75)40(65-33(2)72)22-13-25-62-54(57)58/h3-10,15-20,30,32,39-44,46,64H,11-14,21-29,31H2,1-2H3,(H2,56,74)(H,61,73)(H,65,72)(H,66,78)(H,67,77)(H,68,76)(H,69,75)(H,70,80)(H,71,79)(H4,57,58,62)(H4,59,60,63)/t32-,39+,40+,41+,42-,43+,44+,46-/m1/s1
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Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...


US Patent US9682141 (2017)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%