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Patent code US9682955

Compile Data Set for Download or QSAR

Found 280 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM143561
PNG
(US9682955, 62)
Show SMILES COC(=O)c1cccc(CNc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C30H23Cl2N3O2/c1-37-30(36)23-4-2-3-19(15-23)17-33-29-26-16-22(9-14-27(26)34-18-35-29)28(20-5-10-24(31)11-6-20)21-7-12-25(32)13-8-21/h2-16,18,28H,17H2,1H3,(H,33,34,35)
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n/an/an/an/a 14n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM143559
PNG
(US9682955, 67)
Show SMILES Fc1ccc(cc1)C(c1ccc(F)cc1)c1ccc2ncnc(NC3CCN(CC3)c3ccccc3)c2c1
Show InChI InChI=1S/C32H28F2N4/c33-25-11-6-22(7-12-25)31(23-8-13-26(34)14-9-23)24-10-15-30-29(20-24)32(36-21-35-30)37-27-16-18-38(19-17-27)28-4-2-1-3-5-28/h1-15,20-21,27,31H,16-19H2,(H,35,36,37)
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n/an/an/an/a 1.15E+3n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM143525
PNG
(US9682955, 69)
Show SMILES CC(=O)NCCOc1nc(NCc2ccc(cc2)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C33H27Cl2F3N4O2/c1-20(43)39-16-17-44-32-41-29-15-8-24(30(22-4-11-26(34)12-5-22)23-6-13-27(35)14-7-23)18-28(29)31(42-32)40-19-21-2-9-25(10-3-21)33(36,37)38/h2-15,18,30H,16-17,19H2,1H3,(H,39,43)(H,40,41,42)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM143524
PNG
(US9682955, 72)
Show SMILES NCCOc1nc(NCc2ccc(cc2)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C31H25Cl2F3N4O/c32-24-10-3-20(4-11-24)28(21-5-12-25(33)13-6-21)22-7-14-27-26(17-22)29(40-30(39-27)41-16-15-37)38-18-19-1-8-23(9-2-19)31(34,35)36/h1-14,17,28H,15-16,18,37H2,(H,38,39,40)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM143543
PNG
(US9682955, 74)
Show SMILES NC(=O)Cc1ccc(cc1)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C34H31Cl2N5O/c35-26-8-3-23(4-9-26)33(24-5-10-27(36)11-6-24)25-7-14-31-30(20-25)34(39-21-38-31)40-28-15-17-41(18-16-28)29-12-1-22(2-13-29)19-32(37)42/h1-14,20-21,28,33H,15-19H2,(H2,37,42)(H,38,39,40)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM143522
PNG
(US9682955, 75)
Show SMILES FC(F)(F)c1ccc(CNc2nc(OCCN=[N+]=[N-])nc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C31H23Cl2F3N6O/c32-24-10-3-20(4-11-24)28(21-5-12-25(33)13-6-21)22-7-14-27-26(17-22)29(41-30(40-27)43-16-15-39-42-37)38-18-19-1-8-23(9-2-19)31(34,35)36/h1-14,17,28H,15-16,18H2,(H,38,40,41)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM143540
PNG
(US9682955, 79)
Show SMILES COC(=O)Cc1ccc(cc1)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C35H32Cl2N4O2/c1-43-33(42)20-23-2-13-30(14-3-23)41-18-16-29(17-19-41)40-35-31-21-26(8-15-32(31)38-22-39-35)34(24-4-9-27(36)10-5-24)25-6-11-28(37)12-7-25/h2-15,21-22,29,34H,16-20H2,1H3,(H,38,39,40)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM143639
PNG
(US9682955, 82)
Show SMILES OCCNC(=O)CC(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C31H31Cl2N5O3/c32-23-6-1-20(2-7-23)30(21-3-8-24(33)9-4-21)22-5-10-27-26(17-22)31(36-19-35-27)37-25-11-14-38(15-12-25)29(41)18-28(40)34-13-16-39/h1-10,17,19,25,30,39H,11-16,18H2,(H,34,40)(H,35,36,37)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM143648
PNG
(US9682955, 95)
Show SMILES OC(=O)c1cccc(c1)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C33H28Cl2N4O2/c34-25-9-4-21(5-10-25)31(22-6-11-26(35)12-7-22)23-8-13-30-29(19-23)32(37-20-36-30)38-27-14-16-39(17-15-27)28-3-1-2-24(18-28)33(40)41/h1-13,18-20,27,31H,14-17H2,(H,40,41)(H,36,37,38)
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n/an/an/an/a 3.16E+3n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM143649
PNG
(US9682955, 96)
Show SMILES NC(=O)c1cccc(c1)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C33H29Cl2N5O/c34-25-9-4-21(5-10-25)31(22-6-11-26(35)12-7-22)23-8-13-30-29(19-23)33(38-20-37-30)39-27-14-16-40(17-15-27)28-3-1-2-24(18-28)32(36)41/h1-13,18-20,27,31H,14-17H2,(H2,36,41)(H,37,38,39)
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n/an/an/an/a 218n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM143520
PNG
(US9682955, 100)
Show SMILES CS(=O)(=O)Nc1nc(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H26Cl2F3N5O4S2/c1-43(39,40)37-27-35-24-11-6-19(25(17-2-7-20(29)8-3-17)18-4-9-21(30)10-5-18)16-23(24)26(36-27)34-22-12-14-38(15-13-22)44(41,42)28(31,32)33/h2-11,16,22,25H,12-15H2,1H3,(H2,34,35,36,37)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM143508
PNG
(US9682955, 110)
Show SMILES COC(=O)CS(=O)(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H28Cl2N4O4S/c1-39-27(36)17-40(37,38)35-14-12-24(13-15-35)34-29-25-16-21(6-11-26(25)32-18-33-29)28(19-2-7-22(30)8-3-19)20-4-9-23(31)10-5-20/h2-11,16,18,24,28H,12-15,17H2,1H3,(H,32,33,34)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM143660
PNG
(US9682955, 119)
Show SMILES Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2ncnc(NC3CCN(CC3)C(=O)c3ccccc3)c2c1
Show InChI InChI=1S/C33H28Cl2N4O/c34-26-11-6-22(7-12-26)31(23-8-13-27(35)14-9-23)25-10-15-30-29(20-25)32(37-21-36-30)38-28-16-18-39(19-17-28)33(40)24-4-2-1-3-5-24/h1-15,20-21,28,31H,16-19H2,(H,36,37,38)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM143502
PNG
(US9682955, 122)
Show SMILES FC(F)(F)c1ccc(Nc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1Cl
Show InChI InChI=1S/C28H17Cl3F3N3/c29-19-6-1-16(2-7-19)26(17-3-8-20(30)9-4-17)18-5-12-25-22(13-18)27(36-15-35-25)37-21-10-11-23(24(31)14-21)28(32,33)34/h1-15,26H,(H,35,36,37)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM143667
PNG
(US9682955, 127)
Show SMILES FC(F)(F)c1ccc(CNc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)nc1
Show InChI InChI=1S/C28H19Cl2F3N4/c29-21-7-1-17(2-8-21)26(18-3-9-22(30)10-4-18)19-5-12-25-24(13-19)27(37-16-36-25)35-15-23-11-6-20(14-34-23)28(31,32)33/h1-14,16,26H,15H2,(H,35,36,37)
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n/an/an/an/a 1.73E+3n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM143668
PNG
(US9682955, 128)
Show SMILES CC(Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C30H22Cl2F3N3/c1-18(21-3-2-4-23(15-21)30(33,34)35)38-29-26-16-22(9-14-27(26)36-17-37-29)28(19-5-10-24(31)11-6-19)20-7-12-25(32)13-8-20/h2-18,28H,1H3,(H,36,37,38)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM143668
PNG
(US9682955, 128)
Show SMILES CC(Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C30H22Cl2F3N3/c1-18(21-3-2-4-23(15-21)30(33,34)35)38-29-26-16-22(9-14-27(26)36-17-37-29)28(19-5-10-24(31)11-6-19)20-7-12-25(32)13-8-20/h2-18,28H,1H3,(H,36,37,38)
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n/an/an/an/a 1.04E+4n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM143679
PNG
(US9682955, 131)
Show SMILES FC(F)(F)c1ccc(CNc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cn1
Show InChI InChI=1S/C28H19Cl2F3N4/c29-21-7-2-18(3-8-21)26(19-4-9-22(30)10-5-19)20-6-11-24-23(13-20)27(37-16-36-24)35-15-17-1-12-25(34-14-17)28(31,32)33/h1-14,16,26H,15H2,(H,35,36,37)
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n/an/an/an/a 16n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM143679
PNG
(US9682955, 131)
Show SMILES FC(F)(F)c1ccc(CNc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cn1
Show InChI InChI=1S/C28H19Cl2F3N4/c29-21-7-2-18(3-8-21)26(19-4-9-22(30)10-5-19)20-6-11-24-23(13-20)27(37-16-36-24)35-15-17-1-12-25(34-14-17)28(31,32)33/h1-14,16,26H,15H2,(H,35,36,37)
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n/an/an/an/a 1.27E+3n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM143501
PNG
(US9682955, 132)
Show SMILES CN(Cc1ccc(cc1)C(F)(F)F)c1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C30H22Cl2F3N3/c1-38(17-19-2-9-23(10-3-19)30(33,34)35)29-26-16-22(8-15-27(26)36-18-37-29)28(20-4-11-24(31)12-5-20)21-6-13-25(32)14-7-21/h2-16,18,28H,17H2,1H3
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n/an/an/an/a 173n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM143484
PNG
(US9682955, 133)
Show SMILES FC(F)(F)CC(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H25Cl2F3N4O/c30-21-6-1-18(2-7-21)27(19-3-8-22(31)9-4-19)20-5-10-25-24(15-20)28(36-17-35-25)37-23-11-13-38(14-12-23)26(39)16-29(32,33)34/h1-10,15,17,23,27H,11-14,16H2,(H,35,36,37)
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n/an/an/an/a 7n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM143681
PNG
(US9682955, 138)
Show SMILES FC(F)(F)c1ccc(CNc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C29H20Cl2F3N3/c30-23-10-3-19(4-11-23)27(20-5-12-24(31)13-6-20)21-7-14-26-25(15-21)28(37-17-36-26)35-16-18-1-8-22(9-2-18)29(32,33)34/h1-15,17,27H,16H2,(H,35,36,37)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM143481
PNG
(US9682955, 143)
Show SMILES FC(F)(F)c1ccc(Nc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C28H18Cl2F3N3/c29-21-8-1-17(2-9-21)26(18-3-10-22(30)11-4-18)19-5-14-25-24(15-19)27(35-16-34-25)36-23-12-6-20(7-13-23)28(31,32)33/h1-16,26H,(H,34,35,36)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM143613
PNG
(US9682955, 6)
Show SMILES Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2ncnc(NCCN3CCS(=O)(=O)CC3)c2c1
Show InChI InChI=1S/C27H26Cl2N4O2S/c28-22-6-1-19(2-7-22)26(20-3-8-23(29)9-4-20)21-5-10-25-24(17-21)27(32-18-31-25)30-11-12-33-13-15-36(34,35)16-14-33/h1-10,17-18,26H,11-16H2,(H,30,31,32)
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n/an/an/an/a 35n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM143612
PNG
(US9682955, 9)
Show SMILES FC(F)(F)S(=O)(=O)NC1CCN(C1)c1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H21Cl2F3N4O2S/c27-19-6-1-16(2-7-19)24(17-3-8-20(28)9-4-17)18-5-10-23-22(13-18)25(33-15-32-23)35-12-11-21(14-35)34-38(36,37)26(29,30)31/h1-10,13,15,21,24,34H,11-12,14H2
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n/an/an/an/a 191n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM143608
PNG
(US9682955, 11)
Show SMILES Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2ncnc(NC3CCN(CCc4ccccc4)CC3)c2c1
Show InChI InChI=1S/C34H32Cl2N4/c35-28-11-6-25(7-12-28)33(26-8-13-29(36)14-9-26)27-10-15-32-31(22-27)34(38-23-37-32)39-30-17-20-40(21-18-30)19-16-24-4-2-1-3-5-24/h1-15,22-23,30,33H,16-21H2,(H,37,38,39)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM143626
PNG
(US9682955, 21)
Show SMILES OC(=O)c1ccccc1CN1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C34H30Cl2N4O2/c35-26-10-5-22(6-11-26)32(23-7-12-27(36)13-8-23)24-9-14-31-30(19-24)33(38-21-37-31)39-28-15-17-40(18-16-28)20-25-3-1-2-4-29(25)34(41)42/h1-14,19,21,28,32H,15-18,20H2,(H,41,42)(H,37,38,39)
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n/an/an/an/a 4.82E+3n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM143593
PNG
(US9682955, 25)
Show SMILES OC(=O)c1ccc(s1)S(=O)(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C31H26Cl2N4O4S2/c32-22-6-1-19(2-7-22)29(20-3-8-23(33)9-4-20)21-5-10-26-25(17-21)30(35-18-34-26)36-24-13-15-37(16-14-24)43(40,41)28-12-11-27(42-28)31(38)39/h1-12,17-18,24,29H,13-16H2,(H,38,39)(H,34,35,36)
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n/an/an/an/a 278n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM143583
PNG
(US9682955, 37)
Show SMILES OC(=O)c1cccc(CN2CCC(CC2)Nc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C34H30Cl2N4O2/c35-27-9-4-23(5-10-27)32(24-6-11-28(36)12-7-24)25-8-13-31-30(19-25)33(38-21-37-31)39-29-14-16-40(17-15-29)20-22-2-1-3-26(18-22)34(41)42/h1-13,18-19,21,29,32H,14-17,20H2,(H,41,42)(H,37,38,39)
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n/an/an/an/a 6.76E+3n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM143580
PNG
(US9682955, 39)
Show SMILES OCCOc1nc(NC2CCN(CC2)S(=O)(=O)c2ccc(cc2)C(O)=O)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C35H32Cl2N4O6S/c36-26-8-1-22(2-9-26)32(23-3-10-27(37)11-4-23)25-7-14-31-30(21-25)33(40-35(39-31)47-20-19-42)38-28-15-17-41(18-16-28)48(45,46)29-12-5-24(6-13-29)34(43)44/h1-14,21,28,32,42H,15-20H2,(H,43,44)(H,38,39,40)
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n/an/an/an/a 514n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM143556
PNG
(US9682955, 41)
Show SMILES OCC(CO)(CO)NC(=O)c1ccc(cc1)S(=O)(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C37H37Cl2N5O6S/c38-28-8-1-24(2-9-28)34(25-3-10-29(39)11-4-25)27-7-14-33-32(19-27)35(41-23-40-33)42-30-15-17-44(18-16-30)51(49,50)31-12-5-26(6-13-31)36(48)43-37(20-45,21-46)22-47/h1-14,19,23,30,34,45-47H,15-18,20-22H2,(H,43,48)(H,40,41,42)
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n/an/an/an/a 1.47E+3n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM143578
PNG
(US9682955, 45)
Show SMILES OCCNS(=O)(=O)c1ccc(cc1)C(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C35H33Cl2N5O4S/c36-27-8-1-23(2-9-27)33(24-3-10-28(37)11-4-24)26-7-14-32-31(21-26)34(39-22-38-32)41-29-15-18-42(19-16-29)35(44)25-5-12-30(13-6-25)47(45,46)40-17-20-43/h1-14,21-22,29,33,40,43H,15-20H2,(H,38,39,41)
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n/an/an/an/a 222n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM143570
PNG
(US9682955, 49)
Show SMILES OCC(CO)COc1nc(NCc2cccc(c2)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C33H28Cl2F3N3O3/c34-26-9-4-22(5-10-26)30(23-6-11-27(35)12-7-23)24-8-13-29-28(15-24)31(41-32(40-29)44-19-21(17-42)18-43)39-16-20-2-1-3-25(14-20)33(36,37)38/h1-15,21,30,42-43H,16-19H2,(H,39,40,41)
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n/an/an/an/a 1.93E+3n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM143569
PNG
(US9682955, 53)
Show SMILES OCCCCOc1nc(NCc2cccc(c2)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C33H28Cl2F3N3O2/c34-26-11-6-22(7-12-26)30(23-8-13-27(35)14-9-23)24-10-15-29-28(19-24)31(41-32(40-29)43-17-2-1-16-42)39-20-21-4-3-5-25(18-21)33(36,37)38/h3-15,18-19,30,42H,1-2,16-17,20H2,(H,39,40,41)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM143564
PNG
(US9682955, 55)
Show SMILES OCCOc1nc(NCc2cccc(c2)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C31H24Cl2F3N3O2/c32-24-9-4-20(5-10-24)28(21-6-11-25(33)12-7-21)22-8-13-27-26(17-22)29(39-30(38-27)41-15-14-40)37-18-19-2-1-3-23(16-19)31(34,35)36/h1-13,16-17,28,40H,14-15,18H2,(H,37,38,39)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM143633
PNG
(US9682955, 60)
Show SMILES OC(=O)c1ccc(CNc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C29H21Cl2N3O2/c30-23-10-5-19(6-11-23)27(20-7-12-24(31)13-8-20)22-9-14-26-25(15-22)28(34-17-33-26)32-16-18-1-3-21(4-2-18)29(35)36/h1-15,17,27H,16H2,(H,35,36)(H,32,33,34)
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n/an/an/an/a 5.30E+3n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM143634
PNG
(US9682955, 61)
Show SMILES COC(=O)c1ccc(CNc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C30H23Cl2N3O2/c1-37-30(36)22-4-2-19(3-5-22)17-33-29-26-16-23(10-15-27(26)34-18-35-29)28(20-6-11-24(31)12-7-20)21-8-13-25(32)14-9-21/h2-16,18,28H,17H2,1H3,(H,33,34,35)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM143589
PNG
(US9682955, 64)
Show SMILES CC(C)OC(=O)OCOC(=O)c1ccc(cc1)S(=O)(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C38H36Cl2N4O7S/c1-24(2)51-38(46)50-23-49-37(45)27-7-14-32(15-8-27)52(47,48)44-19-17-31(18-20-44)43-36-33-21-28(9-16-34(33)41-22-42-36)35(25-3-10-29(39)11-4-25)26-5-12-30(40)13-6-26/h3-16,21-22,24,31,35H,17-20,23H2,1-2H3,(H,41,42,43)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM143589
PNG
(US9682955, 64)
Show SMILES CC(C)OC(=O)OCOC(=O)c1ccc(cc1)S(=O)(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C38H36Cl2N4O7S/c1-24(2)51-38(46)50-23-49-37(45)27-7-14-32(15-8-27)52(47,48)44-19-17-31(18-20-44)43-36-33-21-28(9-16-34(33)41-22-42-36)35(25-3-10-29(39)11-4-25)26-5-12-30(40)13-6-26/h3-16,21-22,24,31,35H,17-20,23H2,1-2H3,(H,41,42,43)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM143638
PNG
(US9682955, 65)
Show SMILES Fc1ccc(CNc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C28H20Cl2FN3/c29-22-8-3-19(4-9-22)27(20-5-10-23(30)11-6-20)21-7-14-26-25(15-21)28(34-17-33-26)32-16-18-1-12-24(31)13-2-18/h1-15,17,27H,16H2,(H,32,33,34)
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n/an/an/an/a 2.94E+3n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM143542
PNG
(US9682955, 77)
Show SMILES OC(=O)Cc1ccc(cc1)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C34H30Cl2N4O2/c35-26-8-3-23(4-9-26)33(24-5-10-27(36)11-6-24)25-7-14-31-30(20-25)34(38-21-37-31)39-28-15-17-40(18-16-28)29-12-1-22(2-13-29)19-32(41)42/h1-14,20-21,28,33H,15-19H2,(H,41,42)(H,37,38,39)
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n/an/an/an/a 297n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM143534
PNG
(US9682955, 81)
Show SMILES CCOC(=O)CCC(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C32H32Cl2N4O3/c1-2-41-30(40)14-13-29(39)38-17-15-26(16-18-38)37-32-27-19-23(7-12-28(27)35-20-36-32)31(21-3-8-24(33)9-4-21)22-5-10-25(34)11-6-22/h3-12,19-20,26,31H,2,13-18H2,1H3,(H,35,36,37)
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n/an/an/an/a 2n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM143534
PNG
(US9682955, 81)
Show SMILES CCOC(=O)CCC(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C32H32Cl2N4O3/c1-2-41-30(40)14-13-29(39)38-17-15-26(16-18-38)37-32-27-19-23(7-12-28(27)35-20-36-32)31(21-3-8-24(33)9-4-21)22-5-10-25(34)11-6-22/h3-12,19-20,26,31H,2,13-18H2,1H3,(H,35,36,37)
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n/an/an/an/a 452n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM143641
PNG
(US9682955, 83)
Show SMILES OCCNC(=O)c1cccc(c1)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C35H33Cl2N5O2/c36-27-9-4-23(5-10-27)33(24-6-11-28(37)12-7-24)25-8-13-32-31(21-25)34(40-22-39-32)41-29-14-17-42(18-15-29)30-3-1-2-26(20-30)35(44)38-16-19-43/h1-13,20-22,29,33,43H,14-19H2,(H,38,44)(H,39,40,41)
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n/an/an/an/a 3.50E+3n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM143551
PNG
(US9682955, 84)
Show SMILES OCCNC(=O)c1ccc(cc1)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C35H33Cl2N5O2/c36-27-8-1-23(2-9-27)33(24-3-10-28(37)11-4-24)26-7-14-32-31(21-26)34(40-22-39-32)41-29-15-18-42(19-16-29)30-12-5-25(6-13-30)35(44)38-17-20-43/h1-14,21-22,29,33,43H,15-20H2,(H,38,44)(H,39,40,41)
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n/an/an/an/a 326n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM143643
PNG
(US9682955, 88)
Show SMILES OC(=O)CC(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H26Cl2N4O3/c30-21-6-1-18(2-7-21)28(19-3-8-22(31)9-4-19)20-5-10-25-24(15-20)29(33-17-32-25)34-23-11-13-35(14-12-23)26(36)16-27(37)38/h1-10,15,17,23,28H,11-14,16H2,(H,37,38)(H,32,33,34)
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n/an/an/an/a 799n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM143529
PNG
(US9682955, 94)
Show SMILES COC(=O)c1ccc(cc1)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C34H30Cl2N4O2/c1-42-34(41)24-6-13-29(14-7-24)40-18-16-28(17-19-40)39-33-30-20-25(8-15-31(30)37-21-38-33)32(22-2-9-26(35)10-3-22)23-4-11-27(36)12-5-23/h2-15,20-21,28,32H,16-19H2,1H3,(H,37,38,39)
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n/an/an/an/a 4n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM143649
PNG
(US9682955, 96)
Show SMILES NC(=O)c1cccc(c1)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C33H29Cl2N5O/c34-25-9-4-21(5-10-25)31(22-6-11-26(35)12-7-22)23-8-13-30-29(19-23)33(38-20-37-30)39-27-14-16-40(17-15-27)28-3-1-2-24(18-28)32(36)41/h1-13,18-20,27,31H,14-17H2,(H2,36,41)(H,37,38,39)
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n/an/an/an/a 23n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM143650
PNG
(US9682955, 97)
Show SMILES COC(=O)c1cccc(c1)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C34H30Cl2N4O2/c1-42-34(41)25-3-2-4-29(19-25)40-17-15-28(16-18-40)39-33-30-20-24(9-14-31(30)37-21-38-33)32(22-5-10-26(35)11-6-22)23-7-12-27(36)13-8-23/h2-14,19-21,28,32H,15-18H2,1H3,(H,37,38,39)
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n/an/an/an/a 83n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM143498
PNG
(US9682955, 106)
Show SMILES CC(=O)Nc1nc(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H26Cl2F3N5O3S/c1-17(40)35-28-37-25-11-6-20(26(18-2-7-21(30)8-3-18)19-4-9-22(31)10-5-19)16-24(25)27(38-28)36-23-12-14-39(15-13-23)43(41,42)29(32,33)34/h2-11,16,23,26H,12-15H2,1H3,(H2,35,36,37,38,40)
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n/an/an/an/a 70n/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...


Citation and Details
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%